Traditional Chinese medicine composition for treating immune thrombocytopenic purpura and preparation method of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for treating immune thrombocytopenic purpura and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared by processing the following raw materials: astragalus membranaceus, white paeony root, dioscorea nipponica makino, salviae miltiorrhizae, clinopodium polycephalum and radix rehmanniae praeparata in a certain proportion. The traditional Chinese medicine composition has the efficiacies of activating blood circulation, enriching blood, tonifying qi and controlling blood, is suitable for the immune thrombocytopenic purpura. According to the traditional Chinese medicine differentiation, hemorrhage syndromes are caused by qi deficiency and blood stasis, qi dysfunction in blood control and escape of blood from vessels and channels. Compared with the prior art, the traditional Chinese medicine composition is significant in clinical pharmacodynamic experiment result, high in bioavailability and free of a toxic or side effect.

Description

technical field

[0001] The invention relates to a traditional Chinese medicine composition for treating immune thrombocytopenic purpura and a preparation method thereof, belonging to the technical field of traditional Chinese medicine pharmacy. technical background

[0002] Immune thrombocytopenic purpura (ITP) is clinically characterized by hemorrhage, thrombocytopenia, normal or increased number of bone marrow megakaryocytes, and maturation disorder. Most of them have onset since childhood, recurrent symptoms, protracted and difficult to heal, and eventually develop into refractory thrombocytopenic purpura. Western medicine treats ITP with glucocorticoids as the first choice. Although the increase in peripheral platelet count is faster, the maintenance time is short and recurrence is easy. The long-term remission rate is about 10-20%, and there are many side effects. Spleenectomy or immunosuppressants are often used for hormone ineffective cases. The former is a traumatic...

Examples

Embodiment 1

[0178] prescription:

[0179] Astragalus 750g Paeoniae Alba 500g Pangosaurus 750g

[0180] Danshen 500g, Duanxueliu 500g, Rehmannia glutinosa 250g.

[0181] The preparation method is:

[0182] The above six flavors, Chuanshanlong, Danshen, and Duanxueliu were soaked in 70% ethanol for 12 hours, heated and refluxed to extract twice, the first 2 hours, add 10 times the amount of alcohol, and the second time 1.5 hours, add 8 times the amount of alcohol, filter After that, combine the filtrate; add white peony root, astragalus, rehmannia glutinosa and water to decoct twice, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1.5 hours, and combine the decoction , filtered, and when the filtrate was concentrated to 60°C, the thick paste with a relative density of 1.10 to 1.20 was measured, let it cool, added ethanol to make the alcohol content reach 70%, left it for 48 hours, took the supernatant,...

Embodiment 2

[0184] prescription:

[0185] Astragalus 720g Paeoniae Alba 470g Pangosaurus 720g

[0186] Danshen 470g, Duanxueliu 470g, Rehmannia glutinosa 220g.

[0187] The preparation method is:

[0188] The above six flavors, Chuanshanlong, Danshen, and Duanxueliu were soaked in 70% ethanol for 12 hours, heated and refluxed to extract twice, the first 2 hours, add 10 times the amount of alcohol, and the second time 1.5 hours, add 8 times the amount of alcohol, filter After that, combine the filtrate; add white peony root, astragalus, rehmannia glutinosa and water to decoct twice, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1.5 hours, and combine the decoction , filtered, and when the filtrate was concentrated to 60°C, the thick paste with a relative density of 1.10 to 1.20 was measured, let it cool, added ethanol to make the alcohol content reach 70%, left it for 48 hours, took the supernatant,...

Embodiment 3

[0190] prescription:

[0191] Astragalus 780g Paeoniae Alba 530g Pangosaurus 780g

[0192] Danshen 530g, Duanxueliu 530g, Rehmannia glutinosa 280g.

[0193] The preparation method is:

[0194] The above six flavors, Chuanshanlong, Danshen, and Duanxueliu were soaked in 70% ethanol for 12 hours, heated and refluxed to extract twice, the first 2 hours, add 10 times the amount of alcohol, and the second time 1.5 hours, add 8 times the amount of alcohol, filter After that, combine the filtrate; add white peony root, astragalus, rehmannia glutinosa and water to decoct twice, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1.5 hours, and combine the decoction , filtered, and when the filtrate was concentrated to 60°C, the thick paste with a relative density of 1.10 to 1.20 was measured, let it cool, added ethanol to make the alcohol content reach 70%, left it for 48 hours, took the supernatant,...

technical field

[0001] The invention relates to a traditional Chinese medicine composition for treating immune thrombocytopenic purpura and a preparation method thereof, belonging to the technical field of traditional Chinese medicine pharmacy. technical background

[0002] Immune thrombocytopenic purpura (ITP) is clinically characterized by hemorrhage, thrombocytopenia, normal or increased number of bone marrow megakaryocytes, and maturation disorder. Most of them have onset since childhood, recurrent symptoms, protracted and difficult to heal, and eventually develop into refractory thrombocytopenic purpura. Western medicine treats ITP with glucocorticoids as the first choice. Although the increase in peripheral platelet count is faster, the maintenance time is short and recurrence is easy. The long-term remission rate is about 10-20%, and there are many side effects. Spleenectomy or immunosuppressants are often used for hormone ineffective cases. The former is a traumatic...

Examples

Embodiment 1

[0178] prescription:

[0179] Astragalus 750g Paeoniae Alba 500g Pangosaurus 750g

[0180] Danshen 500g, Duanxueliu 500g, Rehmannia glutinosa 250g.

[0181] The preparation method is:

[0182] The above six flavors, Chuanshanlong, Danshen, and Duanxueliu were soaked in 70% ethanol for 12 hours, heated and refluxed to extract twice, the first 2 hours, add 10 times the amount of alcohol, and the second time 1.5 hours, add 8 times the amount of alcohol, filter After that, combine the filtrate; add white peony root, astragalus, rehmannia glutinosa and water to decoct twice, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1.5 hours, and combine the decoction , filtered, and when the filtrate was concentrated to 60°C, the thick paste with a relative density of 1.10 to 1.20 was measured, let it cool, added ethanol to make the alcohol content reach 70%, left it for 48 hours, took the supernatant,...

Embodiment 2

[0184] prescription:

[0185] Astragalus 720g Paeoniae Alba 470g Pangosaurus 720g

[0186] Danshen 470g, Duanxueliu 470g, Rehmannia glutinosa 220g.

[0187] The preparation method is:

[0188] The above six flavors, Chuanshanlong, Danshen, and Duanxueliu were soaked in 70% ethanol for 12 hours, heated and refluxed to extract twice, the first 2 hours, add 10 times the amount of alcohol, and the second time 1.5 hours, add 8 times the amount of alcohol, filter After that, combine the filtrate; add white peony root, astragalus, rehmannia glutinosa and water to decoct twice, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1.5 hours, and combine the decoction , filtered, and when the filtrate was concentrated to 60°C, the thick paste with a relative density of 1.10 to 1.20 was measured, let it cool, added ethanol to make the alcohol content reach 70%, left it for 48 hours, took the supernatant,...

Embodiment 3

[0190] prescription:

[0191] Astragalus 780g Paeoniae Alba 530g Pangosaurus 780g

[0192] Danshen 530g, Duanxueliu 530g, Rehmannia glutinosa 280g.

[0193] The preparation method is:

[0194] The above six flavors, Chuanshanlong, Danshen, and Duanxueliu were soaked in 70% ethanol for 12 hours, heated and refluxed to extract twice, the first 2 hours, add 10 times the amount of alcohol, and the second time 1.5 hours, add 8 times the amount of alcohol, filter After that, combine the filtrate; add white peony root, astragalus, rehmannia glutinosa and water to decoct twice, add 8 times the amount of water for the first time, decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1.5 hours, and combine the decoction , filtered, and when the filtrate was concentrated to 60°C, the thick paste with a relative density of 1.10 to 1.20 was measured, let it cool, added ethanol to make the alcohol content reach 70%, left it for 48 hours, took the supernatant,...

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