A method for extracting cannabidiol enrichment from industrial hemp

Abstract

The invention discloses a method for extracting cannabidiol concentrate from industrial hemp. The method includes the following steps of alkali liquor extraction, acid precipitation and organic solvent extraction. The organic solvent consumption of the invention is only about 5% of an existing extraction method, solvent consumption and energy consumption are greatly reduced, the investment of corresponding equipment workshops is greatly reduced, and there is no need to invest large-scale solvent recovery equipment facilities and workshop or invest expensive supercritical extraction equipment.The method for extracting cannabidiol concentrate from industrial hemp has low investment cost and low operation cost, the content of cannabidiol in the concentrate is high, and the removal rate of tetrahydrocannabinol is high.

Description

technical field

[0001] The present invention relates to a method for extracting cannabidiol-enriched matter, especially a method for extracting cannabidiol-enriched matter from industrial hemp, and also relates to the cannabidiol-enriched matter obtained by the extraction method, belonging to biochemical industry field. Background technique

[0002] Research data show that cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), and Natural compounds such as terpenes, these substances have high medicinal and health value, especially the most extensive and in-depth research on cannabidiol, and have been fully affirmed in terms of safety and efficacy. At present, cannabidiol and hemp oil rich in cannabidiol have been widely used in medicine, health care products, cosmetics and food, etc. The market prospect is very broad, and the supply of industrial hemp extract is in short supply.

[0003] At present, the extraction method...

Examples

Embodiment 1

[0025] The method for extracting cannabidiol enrichment from industrial hemp of the present embodiment is carried out as follows:

[0026] The dried industrial hemp mosaic raw material is crushed into 50 mesh pieces, weighed 20kg, and placed in an extraction tank. Add 160L of pH=11.5 alkaline water solution prepared with NaOH, stir and extract at room temperature at 150r / min for 1 hour, put the extract into an acid adjustment tank, slowly add sulfuric acid under stirring to make pH=3, and centrifuge The precipitate was separated and dried at 60°C to obtain 637 g of a dry precipitate. The precipitated dry product was extracted by percolation with 7L of absolute ethanol, and the flow rate was 30ml / min / 1kg of the precipitated dry product, extracted for 5-10 hours, and the extract was concentrated to obtain 358g of cannabidiol enriched product. The concentrate contains 41.3% cannabidiol and only 1.41% THC.

Embodiment 2

[0028] The method for extracting cannabidiol enrichment from industrial hemp of the present embodiment is carried out as follows:

[0029] The dried industrial hemp mosaic raw material is crushed into 100 mesh pieces, weighed 20kg, and placed in an extraction tank. Added with Ba(OH) 2 Prepare 200L of pH = 12.5 alkali water, soak and extract at room temperature for 3 hours, put the extract into an acid adjustment tank, slowly add glacial acetic acid under stirring to make pH = 3.5, and obtain a precipitate through centrifugation. Drying at 100°C yielded 679 g of a precipitated dry product. The precipitated dry product was extracted with 13L of petroleum ether under heat reflux three times, and the extraction time was 45min each time. The extract was filtered and concentrated to obtain 326g of cannabidiol enrichment. The concentrate contained 42.6% of cannabidiol and only 1.48% of THC.

Embodiment 3

[0031] The method for extracting cannabidiol enrichment from industrial hemp of the present embodiment is carried out as follows:

[0032] The dried industrial hemp mosaic raw material is crushed into 20 mesh pieces, weighed 20kg, and placed in an extraction tank. Add 280L of pH=13 alkaline water prepared with KOH, soak and extract at room temperature for 5 hours, put the extract into an acid adjustment tank, slowly add glacial acetic acid under stirring to make pH=4, and obtain a precipitate after centrifugation . The precipitate was dried at 150°C to obtain 852 g of a dry product of the precipitate. The dry precipitated product was extracted with 10L of ethyl acetate without stirring three times, each time with a stirring speed of 100r / min and an extraction time of 5h. The extract was filtered and concentrated to obtain 349g of cannabidiol-enriched product. The concentrate contains 43.2% cannabidiol and only 1.52% THC.

technical field

[0001] The present invention relates to a method for extracting cannabidiol-enriched matter, especially a method for extracting cannabidiol-enriched matter from industrial hemp, and also relates to the cannabidiol-enriched matter obtained by the extraction method, belonging to biochemical industry field. Background technique

[0002] Research data show that cannabidiol (CBD), tetrahydrocannabinol (THC), cannabinol (CBN), cannabigerol (CBG), cannabichromene (CBC), and Natural compounds such as terpenes, these substances have high medicinal and health value, especially the most extensive and in-depth research on cannabidiol, and have been fully affirmed in terms of safety and efficacy. At present, cannabidiol and hemp oil rich in cannabidiol have been widely used in medicine, health care products, cosmetics and food, etc. The market prospect is very broad, and the supply of industrial hemp extract is in short supply.

[0003] At present, the extraction method...

Examples

Embodiment 1

[0025] The method for extracting cannabidiol enrichment from industrial hemp of the present embodiment is carried out as follows:

[0026] The dried industrial hemp mosaic raw material is crushed into 50 mesh pieces, weighed 20kg, and placed in an extraction tank. Add 160L of pH=11.5 alkaline water solution prepared with NaOH, stir and extract at room temperature at 150r / min for 1 hour, put the extract into an acid adjustment tank, slowly add sulfuric acid under stirring to make pH=3, and centrifuge The precipitate was separated and dried at 60°C to obtain 637 g of a dry precipitate. The precipitated dry product was extracted by percolation with 7L of absolute ethanol, and the flow rate was 30ml / min / 1kg of the precipitated dry product, extracted for 5-10 hours, and the extract was concentrated to obtain 358g of cannabidiol enriched product. The concentrate contains 41.3% cannabidiol and only 1.41% THC.

Embodiment 2

[0028] The method for extracting cannabidiol enrichment from industrial hemp of the present embodiment is carried out as follows:

[0029] The dried industrial hemp mosaic raw material is crushed into 100 mesh pieces, weighed 20kg, and placed in an extraction tank. Added with Ba(OH) 2 Prepare 200L of pH = 12.5 alkali water, soak and extract at room temperature for 3 hours, put the extract into an acid adjustment tank, slowly add glacial acetic acid under stirring to make pH = 3.5, and obtain a precipitate through centrifugation. Drying at 100°C yielded 679 g of a precipitated dry product. The precipitated dry product was extracted with 13L of petroleum ether under heat reflux three times, and the extraction time was 45min each time. The extract was filtered and concentrated to obtain 326g of cannabidiol enrichment. The concentrate contained 42.6% of cannabidiol and only 1.48% of THC.

Embodiment 3

[0031] The method for extracting cannabidiol enrichment from industrial hemp of the present embodiment is carried out as follows:

[0032] The dried industrial hemp mosaic raw material is crushed into 20 mesh pieces, weighed 20kg, and placed in an extraction tank. Add 280L of pH=13 alkaline water prepared with KOH, soak and extract at room temperature for 5 hours, put the extract into an acid adjustment tank, slowly add glacial acetic acid under stirring to make pH=4, and obtain a precipitate after centrifugation . The precipitate was dried at 150°C to obtain 852 g of a dry product of the precipitate. The dry precipitated product was extracted with 10L of ethyl acetate without stirring three times, each time with a stirring speed of 100r / min and an extraction time of 5h. The extract was filtered and concentrated to obtain 349g of cannabidiol-enriched product. The concentrate contains 43.2% cannabidiol and only 1.52% THC.