A safe herbicide composition containing mesosulfuron

Abstract

The invention discloses a herbicidal composition for improving the safety of mesosulfuron, the herbicidal composition comprises an active ingredient mesosulfuron and a safener 5-aminolevulinic acid, wherein the weight ratio of the mesosulfuron to the 5-aminolevulinic acid is 1:1 to 1:100. 5-aminolevulinic acid is added to the herbicidal composition of the invention, thereby improving the safety of mesosulfuron to crops and reducing the occurrence of phytotoxicity.

Description

Technical Field

[0001] The invention relates to a herbicidal composition for preventing and controlling weeds in wheat fields, in particular to a safe herbicidal composition containing mesosulfuron-methyl. Background Art

[0002] Sulfonylurea herbicides are one of the most important herbicide varieties in the world. Mesosulfuron-methyl is a sulfonylurea herbicide developed by Bayer in Germany in 2002. Mesosulfuron-methyl is mainly absorbed by the stems and leaves of plants, conducted through the phloem and xylem, and absorbed in small amounts through the soil, inhibiting the activity of acetolactate synthase in sensitive plants, resulting in the blockage of branched-chain amino acid synthesis, thereby inhibiting cell division and causing the death of sensitive plants. Its main targets of prevention and control are annual grass weeds such as Alopecurus ovata, wild oats, bluegrass, brome, and Aesculus tauschii, and some broad-leaved weeds such as shepherd's purse, Artemisia selengensis, and Chickweed can also be removed. Under normal circumstances, the absorption of sensitive weeds reaches a peak 2 to 4 hours after application, and they die 2 to 4 weeks later. The chemical structure is as follows:

[0003]

[0004] Methsulfuron has extremely high herbicidal activity and is currently the only stem and leaf treatment herbicide that can effectively control Aegilops tauschii. However, Methsulfuron has high requirements for application technology. It cannot be applied after wheat joints or plant height reaches 13 cm. The safe interval between application and subsequent crops is as long as 90 days. It has poor safety for crops and is easy to cause pesticide damage to crops, causing irreparable losses to farmers and seriously affecting the reputation of manufacturers.

[0005] 5-Aminolevulinic acid (ALA) is a multifunctional plant growth regulator. It is the common precursor of the biosynthesis of all porphyrin compounds. It is a non-protein amino acid widely present in bacteria, fungi, animals and plants. It is a naturally occurring physiologically active substance in plants that is essential for plant life activities and has active metabolism. 5-Aminolevulinic acid can increase the content of chlorophyll synthesis precursors (uroporphyrinogen, protoporphyrin, dollar porphyrin, protochlorophyllide, etc.), promote their conversion into chlorophyll, increase chlorophyll content, and improve photosynthetic capacity. 5-Aminolevulinic acid has multiple functions such as promoting seed germination, shortening the production cycle, improving crop resistance and growth, increasing crop yield, and improving crop quality. 5-Aminolevulinic acid has no toxic side effects, is easily degraded and has no residue. It can be used as a seedling strengthener, yield increaser, color enhancer, greening agent, defoliant, herbicide, insecticide, etc. in agricultural production. The chemical structure is as follows:

[0006]

[0007] 5-aminolevulinic acid can protect crops by improving their stress resistance, enhancing their metabolic activity, reducing the degree of phytotoxicity of mesosulfuron or avoiding the occurrence of phytotoxicity. It is suitable for various wheat varieties and can effectively control a variety of grass weeds and some broadleaf weeds. Literature reports that it can be used as a fertilizer at low dosages and has herbicidal or insecticidal activity at high dosages. Summary of the invention

[0008] The purpose of the present invention is to improve the safety of mesosulfuron to crops. In the processing of mesosulfuron dosage forms, adding an appropriate amount of 5-aminolevulinic acid can improve the safety of mesosulfuron to crops and reduce or avoid the occurrence of pesticide injury accidents.

[0009] The object of the present invention can be achieved by the following measures: a herbicidal composition, the herbicidal composition comprising an active ingredient A and a safener B, wherein the active ingredient A is mesosulfuron and the safener B is 5-aminolevulinic acid;

[0010] Furthermore, the weight ratio of mesosulfuron to 5-aminolevulinic acid is 1:1 to 1:100;

[0011] Furthermore, the weight ratio of mesosulfuron to 5-aminolevulinic acid is 1:1 to 1:50;

[0012] Furthermore, the mass ratio of mesosulfuron to 5-aminolevulinic acid is 1:5 to 1:50;

[0013] Furthermore, the mass ratio of mesosulfuron to 5-aminolevulinic acid is 1:5 to 1:30;

[0014] Furthermore, the mass ratio of mesosulfuron to 5-aminolevulinic acid is 1:5, 1:10, 1:15, 1:20, 1:25, 1:30;

[0015] Further, the herbicidal composition further comprises an adjuvant, and the adjuvant is selected from one or more of a wetting agent, a dispersant, an emulsifier, a thickener, a disintegrant, an antifreeze agent, a defoaming agent, a solvent, a preservative, a stabilizer, a synergist, a dispersion medium and a carrier;

[0016] The present invention provides a herbicidal composition for improving the safety of mesosulfuron-methyl. The herbicidal composition, comprising an active ingredient of mesosulfuron-methyl, a safener 5-aminolevulinic acid and an adjuvant, can be prepared into various dosage forms.

[0017] Further, the dosage forms include wettable powders, water dispersible granules, aqueous emulsions, emulsifiable concentrates, suspensions, and dispersible oil suspensions;

[0018] Further, wettable powders may use adjuvants such as dispersants, wetting agents, fillers, etc.;

[0019] Furthermore, auxiliary agents that may be used in water dispersible granules include dispersants, disintegrants, binders, fillers, etc.;

[0020] Furthermore, the emulsifiable concentrate may use auxiliary agents such as emulsifiers, solvents, etc.;

[0021] Furthermore, the suspension may use auxiliary agents such as dispersants, emulsifiers, wetting agents, thickeners, antifreeze agents, carriers, etc.;

[0022] Furthermore, the dispersible oil suspension may use auxiliary agents such as dispersants, wetting agents, thickeners, antifreeze agents, dispersion media, etc.;

[0023] Further, the dosage form of the preparation is a dispersible oil suspension;

[0024] Dispersible oil suspension is a solid active ingredient well dispersed in oil solvent to form a stable suspension. Dispersible oil suspension has good stability, environmental protection and safety, and can also increase the amount of active ingredients attached to the leaves and improve the utilization rate of pesticides.

[0025] The herbicidal composition and the preparation thereof of the present invention are used for controlling weeds in wheat fields, wherein the weeds in wheat fields are annual grass weeds and some broadleaf weeds;

[0026] Furthermore, the annual grass weeds are one or more of Aegilops tauschii, Bromus, Wild Oats, Lolium multiflorum, Sclerophyll, Glechoma longituba, Alopecuroides australis, Japanese Alopecuroides, and Poa annua; the broadleaf weeds are one or more of Artemisia sophia, Shepherd's Purse, Rhus salsa, Chickweed, and Chickweed.

[0027] Use of 5-aminolevulinic acid for reducing damage to crops caused by herbicidal active compounds;

[0028] Furthermore, the herbicidal active compound is mesosulfuron-methyl.

[0029] By adding 5-aminolevulinic acid to the above-mentioned herbicidal composition containing mesosulfuron, various pesticide formulations are prepared through conventional pesticide formulation processing methods, and the formula with stable physical and chemical properties is screened out through cold and heat stability tests and room temperature storage stability tests. After biological activity determination, a herbicidal composition with high prevention effect, low toxicity, small environmental impact and good safety is obtained. The test results show that when mesosulfuron is mixed with 5-aminolevulinic acid, there will be no antagonistic effect in the biological activity of mesosulfuron; in addition, the phytotoxicity is observed through biological tests, and the results show that the safety of the herbicidal composition is greatly improved compared with mesosulfuron without 5-aminolevulinic acid. DETAILED DESCRIPTION

[0030] In order to make the technical solutions, objectives and advantages of the present invention more clearly understood, the present invention is described with the following specific embodiments, but the present invention can be implemented in various forms and should not be limited by the embodiments described herein.

[0031] Preparation Example

[0032] In order to better illustrate the present invention, the content of the present invention is further described below in conjunction with the embodiments. The parts in all the embodiments are parts by weight.

[0033] Preparation Example 1: 3% mesosulfuron dispersible oil suspension (the mass ratio of mesosulfuron to 5-aminolevulinic acid is 1:5)

[0034] Formula: 3% methyl disulfone, 15% 5-aminolevulinic acid, 6% sodium lignin sulfonate, 5% Nongru 1601#, 3% Tween-60#, 4% Nongru 2201, 4% sodium naphthalene sulfonate, 1% magnesium aluminum silicate, 4% glycerol, and rapeseed oil to make up the balance;

[0035] Preparation method: According to the formula ratio, methyl disulfone, 5-aminolevulinic acid, surfactant and other functional additives are placed in a reaction kettle in sequence, oil is added and mixed evenly, and the product is obtained by high-speed shearing, wet sand grinding, and finally homogenous filtration.

[0036] Preparation Example 2: 3% mesosulfuron suspension (the mass ratio of mesosulfuron to 5-aminolevulinic acid is 1:10)

[0037] Formula: 3% methyl disulfone, 30% 5-aminolevulinic acid, 2% sodium alkyl sulfate, 3% alkylphenol formaldehyde resin polyoxyethylene ether, 0.4% carboxymethyl cellulose, 5% propylene glycol, 0.2% isothiazolinone, and deionized water to make up the balance;

[0038] Preparation method: According to the formula ratio, methyl disulfone, 5-aminolevulinic acid, surfactant and other functional additives are placed in a reaction kettle in sequence, water is added to mix evenly, and the suspension product is obtained by high-speed shearing, wet sand grinding, and finally homogenization filtration.

[0039] Preparation Example 3: 3% mesosulfuron wettable powder (the mass ratio of mesosulfuron to 5-aminolevulinic acid is 1:15)

[0040] Formula: 3% methyl disulfone, 45% 5-aminolevulinic acid, 5% alkylnaphthalene formaldehyde condensate calcium sulfonate, 6% alkylphenol polyoxyethylene ether sulfonate sodium, 3% alkylnaphthalene sulfonate sodium, 5% talc, diatomaceous earth to make up the balance;

[0041] Preparation method: According to the formula ratio of the embodiment, mesosulfuron and 5-aminolevulinic acid are added to a carrier, and a surfactant and other functional additives are added thereto, mixed, and then air flow pulverized and mixed again to obtain a wettable powder.

[0042] Preparation Example 4: 3% mesosulfuron water dispersible granules (the mass ratio of mesosulfuron to 5-aminolevulinic acid is 1:20)

[0043] Formula: 3% methyl disulfone, 60% 5-aminolevulinic acid, 3% polycarboxylate GY-D06, 4% sodium lauryl sulfate, 1% sodium alkyl sulfonate, 2% sucrose, clay makes up the balance;

[0044] Preparation method: According to the formula ratio of the embodiment, methyl disulfone and 5-aminolevulinic acid are added to a carrier, and a surfactant and other functional additives are added thereto, mixed, and after air flow pulverization, 10% to 25% of water is added, and then kneading, granulation, drying, and sieving are performed to obtain a water-dispersible granule product.

[0045] Preparation Example 5: 1% mesosulfuron dispersible oil suspension (the mass ratio of mesosulfuron to 5-aminolevulinic acid is 1:25)

[0046] Formula: 1% methyl disulfone, 25% 5-aminolevulinic acid, 2% sodium polycarboxylate, 4% Nongru 1601#, 3% Tween-60#, 4% Nongru 2201, 1% sodium alkyl sulfate, 0.5% bentonite, 5% propylene glycol, and soybean oil to make up the balance;

[0047] Preparation method: Same as Example 1.

[0048] Preparation method: According to the formula ratio, methyl disulfone, 5-aminolevulinic acid, surfactant and other functional additives are placed in a reaction kettle in sequence, oil is added and mixed evenly, and the product is obtained by high-speed shearing, wet sand grinding, and finally homogenous filtration.

[0049] Preparation Example 6: 3% methyl disulfone emulsifiable concentrate (the mass ratio of methyl disulfone to 5-aminolevulinic acid is 1:15)

[0050] Formula: 3% methyl disulfone, 45% 5-aminolevulinic acid, 20% dimethyl sulfoxide, 5% fatty alcohol polyoxyethylene ether, 9% alkylphenol polyoxyethylene polyoxypropylene ether, 1% calcium dodecylbenzene sulfonate, and methyl oleate makes up the balance;

[0051] Preparation method: Add mesosulfuron and 5-aminolevulinic acid into a carrier according to the formula ratio of the example, and add a surfactant and other functional additives thereto, stir and mix them evenly in a stirring mixing kettle to obtain an emulsifiable concentrate.

[0052] Example 1

[0053] Indoor safety test

[0054] Examples Reference Criteria for the evaluation of the safety of pesticides to crops Part 2: Test methods for the determination of the safety of photosynthetic inhibitory herbicides to crops NY / T1965.2-2010

[0055] Experimental crops: wheat;

[0056] Weeds: Aegilops tauschii, Bromus striata, Artemisia selengensis.

[0057] Test agents: 95% methyl disulfone technical and 99% 5-aminolevulinic acid, both provided by the R&D Center of Hailier Pharmaceutical Group Co., Ltd.

[0058] Preparation: Prepare the preparation according to the preparation methods in Preparation Examples 1 to 6 in the preparation room laboratory of the R&D center of Hailier Pharmaceutical Group Co., Ltd.

[0059] Control 7 was a 3% mesosulfuron dispersible oil suspension (without the addition of 5-aminolevulinic acid).

[0060] Test method: Sow a certain amount of wheat and weed seeds in pots with a diameter of 9 cm, and cultivate them in a light incubator. When the wheat grows to 1-2 tillers and the weeds grow to 1-3 leaves, 20 plants are set in each pot and sprayed. After treatment, continue to cultivate in a greenhouse (temperature 20±1℃, humidity 60%-65%), regularly observe the control effect of each treatment on weeds, and record the fresh weight of wheat and weeds in each treatment after 14 days.

[0061] Experimental treatment: Each treatment was repeated 4 times, and a clear water control was set.

[0062] Data investigation: Calculate the fresh weight of wheat and weeds in each treatment 14 days after spraying.

[0063] The calculation formula is as follows:

[0064] Wheat growth inhibition rate R = (fresh weight of control area - fresh weight of treatment area) / fresh weight of control area × 100

[0065] Weed fresh weight inhibition rate E = (fresh weight of control area - fresh weight of treatment area) / fresh weight of control area × 100

[0066] The test results are shown in Table 1:

[0067] Table 1 Inhibition rate of wheat fresh weight and control effect on fresh weight of Aegilops tauschii and Bromus striata by each treatment

[0068]

[0069]

[0070] Note: The protective effects in the above table are the average protective effects of each replicate. Capital letters represent extremely significant differences at the 1% level, and lowercase letters represent significant differences at the 5% level.

[0071] The results of indoor crop safety and weed control tests showed (Table 1) that the mixture of methyl disulfone and 5-aminolevulinic acid can greatly improve the safety of wheat, with a dosage of 13.5 gai / hm 2 For weed control in wheat fields, 14 days after application, the wheat fresh weight inhibition rate of 3% methyl disulfone dispersible oil suspension without 5-aminolevulinic acid was as high as 24.75%, while the wheat fresh weight inhibition rates of the other 6 treatments with 5-aminolevulinic acid were much lower than those of the control 7. Analysis of the difference results showed that at the 0.01 and 0.05 levels, there was a significant difference in the wheat fresh weight inhibition rate between the preparation and the control, and with the increase in the dosage of the safener 5-aminolevulinic acid, the safety of methyl disulfone was also significantly improved. In terms of weed control, after the addition of the safener 5-aminolevulinic acid, the control effect of methyl disulfone on Aegilops tauschii, Oats and Artemisia sophora japonica did not change significantly.

[0072] Example 2

[0073] Experiment on the efficacy of pesticides against Aegilops tauschii in winter wheat fields in Shandong Province in 2018

[0074] Test location: Zhenwumiao Village, Acheng Town, Yanggu County, Liaocheng City, Shandong Province. The test site is a wheat-corn rotation field with two crops a year. The land is flat and there is a serious outbreak of wheat in the field.

[0075] Application method: Use 3WBD-20 backpack sprayer with fan-shaped nozzle for spraying, the spray pressure is 0.15MPa, and the flow rate is 800mL / min.

[0076] Survey Methodology

[0077] Crop safety: 30 days after application, samples were collected from five points in each plot, and the fresh weight of a 1m single row of wheat was measured at each point;

[0078] Calculation formula: Wheat growth inhibition rate R = (fresh weight of control area - fresh weight of treatment area) / fresh weight of control area × 100

[0079] Weed control effect: 30 days after application, sample five points in each plot, and measure 0.25m at each point 2 fresh weight of internal weeds;

[0080] Calculation formula: Weed fresh weight inhibition rate E = (fresh weight of control area - fresh weight of treatment area) / fresh weight of control area × 100

[0081] The test results are shown in Table 2:

[0082] Table 2 Inhibition rate of wheat fresh weight and control effect on fresh weight of Aegilops tauschii in each treatment

[0083]

[0084]

[0085] Note: The protective effects in the above table are the average protective effects of each replicate. Capital letters represent extremely significant differences at the 1% level, and lowercase letters represent significant differences at the 5% level.

[0086] Through the analysis of the test results, it was found that the mixture of methyldisulfone and the safener 5-aminolevulinic acid can greatly improve the safety of methyldisulfone to wheat. The fresh weight inhibition rate of the control agent without 5-aminolevulinic acid was 15.31%. With the increase of the proportion of 5-aminolevulinic acid, the safety gradually improved. In terms of efficacy, after adding the safener 5-aminolevulinic acid, the control effect of methyldisulfone on wheat was above 63.96%, and there was no significant difference between the treatments below the 0.01 level.

[0087] Example 3

[0088] Efficacy test of oats in winter wheat fields in Henan Province in 2019

[0089] Test location: Changge City Test Base, Xuchang City, Henan Province. The test site is a wheat-corn rotation field with fertile soil and flat terrain, and wheat grows well.

[0090] Wheat planting specifications: planting at equal spacing, with a row spacing of 20cm.

[0091] Application method: Use 3WBD-20 backpack sprayer with fan-shaped nozzle for spraying, the spray pressure is 0.15MPa, and the flow rate is 800mL / min.

[0092] Survey Methodology

[0093] Crop safety: 30 days after application, samples were collected from five points in each plot, and the fresh weight of a 1m single row of wheat was measured at each point;

[0094] Calculation formula: Wheat growth inhibition rate R = (fresh weight of control area - fresh weight of treatment area) / fresh weight of control area × 100

[0095] Weed control effect: 30 days after application, samples were taken from five points in each plot, and the fresh weight of weeds within 0.25 m2 was measured at each point;

[0096] Calculation formula: Weed fresh weight inhibition rate E = (fresh weight of control area - fresh weight of treatment area) / fresh weight of control area × 100

[0097] The test results are shown in Table 3:

[0098] Table 3 Inhibition rate of wheat fresh weight and control effect of wild oats fresh weight of each treatment

[0099]

[0100]

[0101] Note: The protective effects in the above table are the average protective effects of each replicate. Capital letters represent extremely significant differences at the 1% level, and lowercase letters represent significant differences at the 5% level.

[0102] The safety and efficacy test concluded that the mixture of methyldisulfone and the safener 5-aminolevulinic acid can greatly improve the safety of methyldisulfone to wheat, and with the increase of the dosage of the safener 5-aminolevulinic acid, the safety also gradually improves; in terms of efficacy, after adding the safener 5-aminolevulinic acid, the control effect of methyldisulfone on wild oats remained basically unchanged.

[0103] Example 4

[0104] Efficacy test of bromegrass in winter wheat fields in Hebei Province in 2019

[0105] Test location: Shenzhou City Test Base, Hengshui City, Hebei Province. The test site is a wheat-corn rotation field with fertile soil, flat terrain, and good wheat growth.

[0106] Wheat planting specifications: planting at equal spacing.

[0107] Application method: Use 3WBD-20 backpack sprayer with fan-shaped nozzle for spraying, the spray pressure is 0.15MPa, and the flow rate is 800mL / min.

[0108] Survey Methodology

[0109] Crop safety: 30 days after application, samples were collected from five points in each plot, and the fresh weight of a 1m single row of wheat was measured at each point;

[0110] Calculation formula: Wheat growth inhibition rate R = (fresh weight of control area - fresh weight of treatment area) / fresh weight of control area × 100

[0111] Weed control effect: 30 days after application, sample five points in each plot, and measure 0.25m at each point 2 fresh weight of internal weeds;

[0112] Calculation formula: Weed fresh weight inhibition rate E = (fresh weight of control area - fresh weight of treatment area) / fresh weight of control area × 100

[0113] The test results are shown in Table 4:

[0114] Table 4 Inhibition rate of wheat fresh weight and control effect of each treatment on brome

[0115]

[0116]

[0117] Note: The protective effects in the above table are the average protective effects of each replicate. Capital letters represent extremely significant differences at the 1% level, and lowercase letters represent significant differences at the 5% level.

[0118] The results of the field efficacy test showed (Table 4): the mixture of methyl disulfone and the safener 5-aminolevulinic acid can greatly improve the safety of methyl disulfone to wheat. The fresh weight inhibition rate of the herbicide with the addition of 5-aminolevulinic acid is significantly lower than that without the addition, and with the increase in the amount of the safener 5-aminolevulinic acid, the safety is gradually improved. At the levels of 0.01 and 0.05, the fresh weight inhibition rates of Preparation Examples 1 to 6 are significantly different from those of Control 7. In terms of efficacy, after the addition of the safener 5-aminolevulinic acid, the control effect of methyl disulfone on brome is basically unchanged.

[0119] Example 5

[0120] Efficacy test of Alopecuroides and Alopecuroides in winter wheat fields in Anhui Province in 2019

[0121] Test location: Hexian test base in Ma'anshan City, Anhui Province. The test site is a wheat-rice rotation field with fertile soil and flat terrain, and wheat grows well.

[0122] Wheat planting specifications: broadcasting.

[0123] Application method: Use 3WBD-20 backpack sprayer with fan-shaped nozzle for spraying, the spray pressure is 0.15MPa, and the flow rate is 800mL / min.

[0124] Survey Methodology

[0125] Crop safety: 30 days after application, samples were collected from five points in each plot, and the fresh weight of a 1m single row of wheat was measured at each point;

[0126] Calculation formula: Wheat growth inhibition rate R = (fresh weight of control area - fresh weight of treatment area) / fresh weight of control area × 100

[0127] Weed control effect: 30 days after application, sample five points in each plot, and measure 0.25m at each point 2 fresh weight of internal weeds;

[0128] Calculation formula: Weed fresh weight inhibition rate E = (fresh weight of control area - fresh weight of treatment area) / fresh weight of control area × 100

[0129] The test results are shown in Table 5:

[0130] Table 5 The fresh weight inhibition rate of wheat and the fresh weight control effect on Alopecurus alopecurus and Alopecurus sibiricus of each treatment

[0131]

[0132]

[0133] Note: The protective effects in the above table are the average protective effects of each replicate. Capital letters represent extremely significant differences at the 1% level, and lowercase letters represent significant differences at the 5% level.

[0134] As shown in Table 5, the fresh weight inhibition rate of wheat and the fresh weight control effect on alopecuroides and weeds of each treatment showed that methyl disulfone had a good control effect on alopecuroides and weeds in wheat fields, with a control effect of more than 70%; the mixture of methyl disulfone and safener 5-aminolevulinic acid can greatly improve the safety of methyl disulfone to wheat, and with the increase of the dosage of safener 5-aminolevulinic acid, the safety of wheat is gradually improved.

[0135] Results and Analysis:

[0136] Through indoor safety and weed efficacy tests, and field tests in Shandong, Henan, Hebei, and Anhui, it can be found that the composition of methyl disulfone and 5-aminolevulinic acid of the present invention can greatly improve the safety of methyl disulfone in the composition to crops, especially wheat, and basically does not affect the control effect of methyl disulfone on weeds.

[0137] Although the present invention has been described in detail above with general instructions and specific implementation schemes, it is obvious to those skilled in the art that some modifications or improvements can be made on the basis of the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention are within the scope of protection claimed by the present invention.

Claims

1. A herbicidal composition, characterized in that The herbicidal composition comprises an active ingredient A and a safener B, wherein the active ingredient A is mesosulfuron-methyl, the safener B is 5-aminolevulinic acid, and the mass ratio of mesosulfuron-methyl to 5-aminolevulinic acid is 1:5-1:

30.

2. The herbicidal composition according to claim 1, characterized in that The herbicidal composition further comprises an adjuvant; the adjuvant is selected from one or more of a wetting agent, a dispersant, an emulsifier, a thickener, a disintegrator, an antifreeze agent, a defoaming agent, a solvent, a preservative, a stabilizer, a synergist, a dispersion medium and a carrier.

3. The herbicidal composition according to claim 1, characterized in that The herbicidal composition comprising the active ingredient mesosulfuron, the safener 5-aminolevulinic acid and the auxiliary agent can be prepared into various dosage forms.

4. The herbicidal composition according to claim 3, characterized in that: The dosage forms include wettable powders, water-dispersible granules, aqueous emulsions, emulsifiable concentrates, suspensions, and dispersible oil suspensions.

5. The herbicidal composition according to claim 4, characterized in that: The dosage form is a dispersible oil suspension.

6. Use of the herbicidal composition and the preparation thereof according to any one of claims 1 to 5 in controlling weeds in wheat fields.

7. The use according to claim 6, characterized in that The wheat field weeds are annual grass weeds and some broad-leaved weeds; the annual grass weeds are one or more of Aegilops tauschii, Bromus, wild oats, Lolium multiflorum, Sclerophyllum, Glechoma longituba, Alopecuroides australis, Japanese Alopecuroides, and Poa annua; the broad-leaved weeds are one or more of Artemisia sophora japonica, Shepherd's purse, Rhus salsa, Chickweed, and Chickweed.

8. Use of 5-aminolevulinic acid for reducing the damage caused by herbicidal active compounds to crops, characterized in that: The herbicidally active compound is mesosulfuron-methyl.

Images