Preparation method and device of heat-sensitive fluid for targeted thermal therapy, and thermal therapy device and method

Abstract

The present invention discloses a method and device for preparing a thermosensitive fluid for targeted thermotherapy, and a thermotherapy device and method, wherein the thermotherapy device comprises: a thermosensitive fluid intake device, configured to inject the thermosensitive fluid into the body circulation system of the treatment object; a microwave radiation device, configured to provide a microwave radiation field with a set wavelength and frequency; a microwave imaging temperature measuring device, configured to detect the temperature and position of the thermosensitive fluid in the body of the treatment object, and output a thermal imaging signal; a control device, configured to receive the thermal imaging signal, control the microwave radiation device to output microwave radiation with a set wavelength and frequency, by combining a thermosensitive object that can generate heat in the microwave radiation field with a tumor tissue antibody, using the antibody to accurately identify the tumor tissue or cells, and then using the heat generated by the thermosensitive object in the microwave radiation field to kill the tumor tissue, and the whole process will not affect normal tissue cells.

Description

Technical Field

[0001] The present invention relates to the technical field of medical instruments and devices, and more specifically, to a method and device for preparing a heat-sensitive fluid for biological targeted thermal therapy for tumor treatment, and a biological targeted thermal therapy device for tumor treatment and a control method thereof. Background Art

[0002] In current technology, the most common treatment methods for killing tumor cells or tissues in the human or animal body include radiotherapy, chemotherapy and surgery. Radiotherapy is the use of high-energy particle rays produced by radioactive elements to bombard tumor cells, thereby achieving the purpose of killing tumor cells. Surgical treatment uses medical physics to remove tumor cells from the human body. For metastatic cancer and multiple tumors, the current commonly used method is to use targeted drugs, that is, chemotherapy, to deliver drugs that act on tumor cells to tumor tissue to kill tumor tissue.

[0003] The above-mentioned treatment methods and devices may also cause damage to the normal tissue cells of the human body when killing tumor tissue. For example, in current radiotherapy, the targeting of drug delivery is not very accurate, and normal tissues usually located near tumor tissues will also be killed, causing damage to the patient's body and obvious side effects. Summary of the invention

[0004] In view of the problem that normal tissue cells of the human body are easily injured in the process of killing tumor tissue in actual use, causing damage to the patient's body and incomplete killing of tumor tissue cells, the first purpose of the present invention is to propose a method for preparing a thermosensitive fluid for biological targeted thermal therapy for tumor treatment, which can prepare a thermosensitive fluid with targeted delivery function, and deliver the thermosensitive material that can generate heat in the microwave radiation field to the tumor tissue. The second purpose of the present invention is to propose a device for preparing a thermosensitive fluid for biological targeted thermal therapy for tumor treatment. Based on the above-mentioned thermosensitive fluid, the third purpose of the present invention is to protect a biological targeted thermal therapy device for tumor treatment, which uses antibodies naturally carried by the human or animal body as a carrier to accurately identify tumor tissue or cells, and releases the temperature-raising agent to the above-mentioned area in a concentrated manner, and realizes accurate heating of tumor tissue or cells by microwave heating, thereby killing the middle-path tissue or blocking the spread of tumor tissue or cells. Based on the above-mentioned treatment device, the fourth purpose of the present invention is to provide a control method for a biological targeted thermal therapy device for tumor treatment, combined with the above-mentioned treatment device, to improve the killing effect of tumor tissue. The specific scheme is as follows:

[0005] A method for preparing a heat-sensitive fluid for biological targeted thermal therapy for tumor treatment comprises the following steps:

[0006] Analyze the medical characteristics of tumor tissue and obtain antibodies for treatment;

[0007] Proliferating and preparing the above-extracted antibodies based on in vitro multiplication technology;

[0008] Analyze the characteristics of the above-mentioned antibody, and prepare a thermosensitive object that can bind to the antibody and generate heat in a set microwave radiation field;

[0009] The thermosensitive substance is combined with the antibody in a specific preparation environment to prepare a thermosensitive fluid with a set fluidity.

[0010] Through the above technical scheme, the antibodies naturally formed by the treatment object against tumor tissues or cells can be used as guiding carriers for targeted treatment, and the thermosensitive body can be accurately carried to attach to the tumor tissues or cells to be killed. Then, microwaves are used to irradiate the treatment object, and the heat generated by the thermosensitive fluid is used to heat the tumor tissues or cells, and then kill them, thereby achieving the purpose of accurate and non-invasive treatment of tumors.

[0011] Based on the above preparation method, the present invention also aims to protect a device for preparing a thermosensitive fluid for biological targeted thermal therapy for tumor treatment, comprising:

[0012] a device for obtaining antibodies for a therapeutic subject;

[0013] A device for purifying and multiplying the above-mentioned antibodies;

[0014] A device for preparing a specific thermosensitive substance according to the above antibody characteristics;

[0015] A device for combining the above-mentioned antibody with a thermosensitive substance to form a fluid with a set fluidity.

[0016] Based on the above-mentioned heat-sensitive fluid, the present invention also aims to protect a biological targeted thermal therapy device for tumor treatment, comprising:

[0017] a thermally sensitive fluid intake device configured to inject a thermally sensitive fluid into the body circulatory system of a subject;

[0018] A microwave radiation device configured to provide a microwave radiation field having a set wavelength and frequency;

[0019] A microwave imaging temperature measuring device configured to detect the temperature and location of a heat-sensitive fluid in the body of a treatment subject and output a thermal imaging signal;

[0020] The control device is configured to be signal-connected to the microwave imaging temperature measuring device and control-connected to the microwave radiation device, receive the thermal imaging signal, and control the microwave radiation device to output microwave radiation of set wavelength and frequency.

[0021] Through the above technical solution, the heat-sensitive fluid that can generate heat in the microwave radiation field is injected into the body circulatory system of the treated object, and the heat-sensitive fluid is transported to the tumor tissue or cells by the treatment object's own circulatory system, so that it combines with the tumor tissue or cells. Then, microwave heating is used and the microwave imaging temperature measurement device is used to monitor the temperature of the heated part, that is, the part where the heat-sensitive fluid is gathered, and the microwave wavelength and power output by the microwave radiation device are adjusted in real time to achieve closed-loop precise control of microwave heating, thereby being able to kill tumor tissue or cells more accurately.

[0022] Furthermore, the biological targeted thermal therapy device also includes a fixing device for adjusting the position of the body of the treatment object in the microwave radiation field.

[0023] Through the above technical solution, the position of the body of the treated object in the microwave radiation field can be changed, and the microwave radiation received by the body can be adjusted so that the above microwave radiation is mainly concentrated at the location of the heat-sensitive fluid, that is, the location of the tumor tissue or cells.

[0024] Furthermore, the retaining device comprises:

[0025] A bed body, disposed in the microwave radiation field, configured to provide a stable support structure for a treatment object;

[0026] The bed driving member is configured to be controllably connected to the control device and is used to drive and change the position of the bed in the three-dimensional space.

[0027] Furthermore, the biological targeted hyperthermia device further comprises a hyperthermia scheme generating device configured as follows:

[0028] A tumor tissue imaging acquisition unit, used to automatically collect or receive external input information to generate the shape, size and position coordinates of the tumor tissue in the subject;

[0029] a thermosensitive fluid dosage generating unit, configured to be connected to the tumor tissue imaging acquiring unit signal, and to generate and output thermosensitive fluid dosage information based on a set algorithm according to the shape, size and position coordinates of the tumor tissue;

[0030] The microwave radiation parameter generating unit is configured to be signal-connected to the tumor tissue imaging acquiring unit, and to generate and output microwave radiation parameter information according to the shape and size, position coordinates and thermosensitive fluid dosage information of the tumor tissue.

[0031] Through the above technical solution, the amount of the above-mentioned thermosensitive fluid and the corresponding microwave radiation parameters can be automatically calculated according to the shape, size and position coordinates of the tumor tissue in the body of the treated object, thereby achieving accurate killing of the tumor tissue in a short time.

[0032] Furthermore, the biological targeted thermal therapy device also includes a thermosensitive fluid flow direction monitoring device, which is configured to be signal-connected to the microwave imaging temperature measurement device, receive the thermal imaging signal of the thermosensitive fluid, and generate and output the flow path and enrichment area information of the thermosensitive fluid.

[0033] Through the above technical solution, on the one hand, the flow direction of the thermosensitive fluid can be monitored to ensure that the thermosensitive material in the thermosensitive fluid can reach the tumor tissue, thereby avoiding damage to the normal tissue cells of the treated object during heat therapy; on the other hand, the shape and size of the tumor tissue can be re-verified through the imaging after the thermosensitive fluid is gathered, thereby ensuring that the amount of thermosensitive fluid is sufficient and the heat therapy effect is guaranteed.

[0034] Furthermore, the biological targeted hyperthermia treatment device further comprises:

[0035] A safety monitoring device configured to be connected to the microwave imaging temperature measuring device by signal, receive the thermal imaging signal of the heat-sensitive fluid, analyze the temperature of the heat-sensitive fluid and compare it with a set value, and output an alarm signal to the control device if it exceeds a set range;

[0036] The safety execution device is configured in the control device, receives the alarm signal, and outputs an internal control signal to control the control device to adjust the output of the microwave radiation device.

[0037] Through the above technical scheme, the temperature changes of the thermosensitive fluid and the normal tissue cells of the treatment object can be monitored in real time during the thermal therapy process. When it exceeds the preset range, the radiation wavelength or power of the microwave radiation device is adjusted in time, thereby avoiding damage to the normal tissue of the treatment object caused by the thermosensitive fluid or microwaves.

[0038] Furthermore, the microwave radiation device includes a plurality of microwave radiators arranged on a mounting bracket, and the plurality of microwave radiators are slidably arranged on the mounting bracket and connected to an external microwave source and a power regulation module.

[0039] Through the above technical scheme, not only can a microwave radiation field with diversified radiation directions be provided, but also the microwave radiation density in the microwave radiation field can be adjusted by dispersing or gathering multiple microwave radiators.

[0040] Based on the above-mentioned thermal therapy device, the present invention also proposes a biological targeted thermal therapy method for tumor treatment, comprising:

[0041] According to the shape and size of the tumor tissue in the body of the treatment subject, a set amount of the aforementioned heat-sensitive fluid is prepared;

[0042] Injecting the thermosensitive fluid into the body circulatory system of the subject and maintaining it for a set time to ensure that the thermosensitive substance in the thermosensitive fluid is enriched in the target tumor tissue or cells;

[0043] Placing the treatment object in a microwave radiation field of a set radiation intensity, monitoring and gradually adjusting the microwave radiation intensity so that the temperature of the thermosensitive fluid is maintained at a set value and lasts for a set time;

[0044] The treatment object is separated from the microwave radiation field and the treatment is completed.

[0045] Through the above technical solution, the tumor tissue can be accurately identified by using the treatment object antibody in the heat-sensitive fluid, and the heat-sensitive object can be sent to the tumor tissue. The microwave radiation in the microwave radiation field makes the heat-sensitive object heat up, and the tumor tissue is heated to a set temperature and maintained for a set time, and finally the tumor tissue or cells are killed. The whole process is non-invasive and will not cause damage to the normal tissue cells of the treatment object.

[0046] Compared with the prior art, the present invention has the following beneficial effects:

[0047] (1) By combining a thermosensitive substance that can generate heat in a microwave radiation field with a tumor tissue antibody, the antibody is used to accurately identify tumor tissue or cells, and then the heat generated by the thermosensitive substance in the microwave radiation field is used to kill the tumor tissue. The whole process will not affect normal tissue cells.

[0048] (2) The heat-sensitive fluid injected into the body of the treated person during the treatment process does not affect tissue cells. After the heat treatment is over, it is naturally discharged out of the body of the treated person through metabolism. It is a pure non-invasive physical treatment with no side effects.

[0049] (3) The treatment method of the present invention can not only kill tumor tissues or cells, but also block the spread of tumor cells to a certain extent, inhibiting the further development of the disease. BRIEF DESCRIPTION OF THE DRAWINGS

[0050] Figure 1 A schematic diagram of a method for preparing a heat-sensitive fluid for biological targeted thermal therapy;

[0051] Figure 2 Schematic diagram of biological targeted hyperthermia method for tumor treatment;

[0052] Figure 3 It is a schematic diagram of the functional module framework of the present invention;

[0053] Figure 4 It is a schematic diagram of the overall structure of the present invention.

[0054] Figure numerals: 1. thermosensitive fluid intake device; 2. microwave radiation device; 3. microwave imaging temperature measuring device; 4. control device; 5. fixing device; 6. bed; 7. bed driving part; 8. thermal therapy plan generating device; 9. tumor tissue imaging acquisition unit; 10. thermosensitive fluid dosage generating unit; 11. microwave radiation parameter generating unit; 12. thermosensitive fluid flow direction monitoring device; 13. safety monitoring device; 14. safety execution device; 15. microwave radiator; 16. mounting bracket. DETAILED DESCRIPTION

[0055] The present invention will be further described in detail below in conjunction with embodiments and figures, but the embodiments of the present invention are not limited thereto.

[0056] like Figure 1 As shown, a method for preparing a heat-sensitive fluid for biological targeted thermal therapy for tumor treatment comprises the following steps:

[0057] S1, analyze the medical characteristics of tumor tissue and obtain antibodies for treatment;

[0058] S2, proliferating and preparing the above-extracted antibodies based on in vitro multiplication technology;

[0059] S3, analyzing the characteristics of the antibody, and preparing a thermosensitive object that can bind to the antibody and generate heat in a set microwave radiation field;

[0060] S4, combining the thermosensitive substance with the antibody in a specific preparation environment to prepare a thermosensitive fluid with a set fluidity.

[0061] In the above step S1, the analysis of the medical characteristics of the tumor tissue is mainly used to find the corresponding antibodies. For different tumor tissues, there are relatively complete antibody extraction methods in the current medical field, that is, immune proteins that have an inhibitory effect on the reproduction of tumor tissue cells.

[0062] In step S2, in vitro antibody proliferation technology is used, and the process generally involves placing antibody cells in a specific culture vessel and providing a suitable growth environment to achieve in vitro cell proliferation.

[0063] In step S3, the heat-sensitive material is preferably a non-toxic substance, such as Fe3O4 particles or a combination thereof.

[0064] In step S4, in order to enable the thermosensitive substance to combine with the antibody, the particle size of the thermosensitive substance is nanometer level. After the thermosensitive substance combines with the antibody, it is combined with a set solution, such as saline, to form a thermosensitive fluid, which is finally injected into the body of the treatment object.

[0065] Through the above technical scheme, the antibodies naturally formed by the treatment object against tumor tissues or cells can be used as guiding carriers for targeted treatment, and the thermosensitive body can be accurately carried to attach to the tumor tissues or cells to be killed. Then, microwaves are used to irradiate the treatment object, and the heat generated by the thermosensitive fluid is used to heat the tumor tissues or cells, and then kill them, thereby achieving the purpose of precise and non-invasive treatment of tumors.

[0066] Based on the above preparation method, the present invention also aims to protect a device for preparing a thermosensitive fluid for biological targeted thermal therapy for tumor treatment, comprising:

[0067] a device for obtaining antibodies for a therapeutic subject;

[0068] A device for purifying and multiplying the above-mentioned antibodies;

[0069] A device for preparing a specific thermosensitive substance according to the above antibody characteristics;

[0070] A device for combining the above-mentioned antibody with a thermosensitive substance to form a fluid with a set fluidity.

[0071] The above method and device for obtaining the antibody of the treatment object include cell separation and purification equipment, such as separating and purifying antibodies from the patient's blood. The multiplication device can use a constant temperature incubator and other instruments, which are used for the proliferation of antibodies in a set pH culture environment. The above process and equipment are currently used in various laboratories and will not be described in detail.

[0072] The device for preparing the specific heat-sensitive substance includes a Fe3O4 particle preparation machine, which prepares Fe3O4 to a set particle size under specific conditions. The device for combining the antibody with the heat-sensitive substance can be the cell proliferation device itself. During the antibody proliferation process, a solution containing a set Fe3O4 particle concentration is directly added to the culture dish as a culture medium.

[0073] Based on the above-mentioned heat-sensitive fluid, the present invention also aims to protect a biological targeted thermal therapy device for tumor treatment, such as Figure 3 As shown, it mainly includes a thermosensitive fluid intake device 1, a microwave radiation device 2, a microwave imaging temperature measurement device 3 and a control device 4.

[0074] The thermosensitive fluid intake device 1 is configured to inject the thermosensitive fluid into the body circulatory system of the treatment object, such as a syringe or a medical device alternative thereto. In order to reduce the circulation time, the above-mentioned thermosensitive fluid intake device 1 can use a long needle syringe to accurately inject the thermosensitive fluid into the tumor tissue or cells in the body of the treatment object in an ultrasonic imaging environment, so that the Fe3O4 particles in the thermosensitive fluid can be accurately and quickly attached to the tumor tissue.

[0075] In order to change the position of the body of the treatment object in the microwave radiation field and thus adjust the microwave radiation received by the body, the biological targeted thermal therapy device also includes a retaining device 5 for adjusting the position state of the body of the treatment object in the microwave radiation field, so that the above-mentioned microwave radiation is mainly concentrated at the location of the heat-sensitive fluid, that is, the location of the tumor tissue or cells.

[0076] Detailed, such as Figure 3 and 4 As shown, the retaining device 5 includes a bed 6 and a bed driving component 7 .

[0077] The bed 6 is arranged in the microwave radiation field and is configured to provide a stable support structure for the treatment object. In order not to block the microwave radiation, the bed 6 is made of ceramic or glass material. Auxiliary fixing devices such as straps are arranged on the bed 6, and the treatment object and the bed 6 are fixed together by the straps during thermal treatment. The bed driving member 7 is configured to be connected to the control device 4 for driving and changing the position of the bed 6 in three-dimensional space. In a specific embodiment, as Figure 4 As shown, the above-mentioned bed body 6 can be realized by using two-section robotic arms, and the controller of the robotic arms is controlled and connected with the control device 4 to drive the bed body 6 to move in three-dimensional space.

[0078] The microwave radiation device 2 is configured to provide a microwave radiation field with a set wavelength and frequency. In the present embodiment, the microwave radiation device 2 comprises a plurality of microwave radiators 15 arranged on a mounting bracket 16, wherein the plurality of microwave radiators 15 are slidably arranged on the mounting bracket 16 and connected to an external microwave source and a power adjustment module. Preferably, the mounting bracket 16 is arranged in a ring or tile shape, and the microwave radiator 15 is detachably arranged on the mounting bracket 16 through a clamp. The above technical solution can not only provide a microwave radiation field with diversified radiation directions, but also can adjust the microwave radiation density in the microwave radiation field by dispersing or gathering a plurality of microwave radiators 15.

[0079] The microwave imaging temperature measuring device 3 is configured to detect the temperature and location of the heat-sensitive fluid in the body of the treatment object and output a thermal imaging signal. The microwave imaging temperature measuring device 3 is implemented by a microwave thermometer combined with a microwave imager. It should be noted that before the thermal treatment process, the imaging of the tumor tissue can come from other medical equipment such as a CT machine.

[0080] In the present invention, the control device 4 is configured to be signal-connected to the microwave imaging temperature measuring device 3 and control-connected to the microwave radiating device 2, receive the thermal imaging signal, and control the microwave radiating device 2 to output microwave radiation of a set wavelength and frequency. In a specific implementation, the control device 4 can be implemented by a computer or microprocessor loaded with a set algorithm program.

[0081] In order to kill tumor tissue more accurately, the biological targeted hyperthermia device further includes a hyperthermia scheme generating device 8 , including a tumor tissue imaging acquisition unit 9 , a thermosensitive fluid dosage generating unit 10 and a microwave radiation parameter generating unit 11 .

[0082] The tumor tissue imaging acquisition unit 9 is used to automatically collect or receive external input information to generate the shape, size and position coordinates of the tumor tissue in the body of the treatment object. The above-mentioned tumor tissue shape and size information can be radiated by microwaves through the microwave radiation device 2, and then reflected or dissipated by the body of the treatment object, and the shape and size of the tumor tissue are presented in the microwave imaging temperature measurement device 3, or the above-mentioned information can be obtained by CT scanning before microwave thermal therapy. The thermosensitive fluid dosage generation unit 10 is configured to be connected to the tumor tissue imaging acquisition unit 9 by signal, and generate and output the thermosensitive fluid dosage information based on the set algorithm according to the tumor tissue shape, size and position coordinates. The microwave radiation parameter generation unit 11 is configured to be connected to the tumor tissue imaging acquisition unit 9 by signal, and generate and output microwave radiation parameter information according to the tumor tissue shape, size, position coordinates and thermosensitive fluid dosage information. The above-mentioned microwave radiation parameter information includes but is not limited to parameters such as microwave wavelength, frequency, and radiation duration.

[0083] Based on the above technical solution, the amount of the above-mentioned thermosensitive fluid and the corresponding microwave radiation parameters can be automatically calculated according to the shape, size and position coordinates of the tumor tissue in the body of the treated object, thereby achieving accurate killing of the tumor tissue in a short time.

[0084] Further optimized, the biological targeted thermal therapy device also includes a thermosensitive fluid flow direction monitoring device 12, which is configured to be connected to the microwave imaging temperature measuring device 3 by signal, receive the thermal imaging signal of the thermosensitive fluid, generate and output the flow path and enrichment area information of the thermosensitive fluid. The thermosensitive fluid flow direction monitoring device 12 includes a program module built into the control device 4, the program module regularly collects the output signal of the microwave imaging temperature measuring device 3, records the position information of the thermosensitive fluid at each time point, and when the thermosensitive fluid is stably gathered at a certain position of the treatment object, it is determined that the thermosensitive fluid has been stably attached to the tumor tissue or cells. The above technical solution, on the one hand, can monitor the flow direction of the thermosensitive fluid, ensure that the thermosensitive material in the thermosensitive fluid can reach the tumor tissue, and avoid damage to the normal tissue cells of the treatment object during thermal therapy; on the other hand, the shape and size of the tumor tissue can be re-verified through the imaging after the thermosensitive fluid is gathered, to ensure that the amount of thermosensitive fluid is sufficient and the thermal therapy effect is guaranteed.

[0085] The biological targeted thermal therapy device further includes a safety monitoring device 13 and a safety execution device 14 .

[0086] The safety monitoring device 13 is configured to be signal-connected to the microwave imaging temperature measuring device 3, receive the thermal imaging signal of the thermosensitive fluid, analyze the temperature of the thermosensitive fluid and compare it with the set value, and if it exceeds the set range, output an alarm signal to the control device 4. The safety execution device 14 is configured in the control device 4, receives the alarm signal, and outputs an internal control signal to control the control device 4 to adjust the output of the microwave radiation device 2. The above technical scheme can monitor the temperature changes of the thermosensitive fluid and the normal tissue cells of the treatment object in real time during the thermal therapy process, and adjust the radiation wavelength or power of the microwave radiation device 2 in time when it exceeds the preset range, thereby avoiding the thermosensitive fluid or microwave from causing damage to the normal tissue of the treatment object. In a specific embodiment, the above safety monitoring device 13 and the safety execution device 14 can be implemented using a program module built into the control device 4.

[0087] The biological targeted hyperthermia device of the present invention has the following working principles and beneficial effects:

[0088] The heat-sensitive fluid that can generate heat in the microwave radiation field is injected into the body circulatory system of the treated object, and the heat-sensitive fluid is transported to the tumor tissue or cells by the treatment object's own circulatory system, so that it combines with the tumor tissue or cells. Then, microwave heating is used and the microwave imaging temperature measuring device 3 is used to monitor the temperature of the heated part, that is, the part where the heat-sensitive fluid is gathered, and the microwave wavelength and power output by the microwave radiation device 2 are adjusted in real time to achieve closed-loop precise control of microwave heating, thereby being able to kill tumor tissue or cells more accurately.

[0089] Based on the above biological targeted hyperthermia device, the present invention also proposes a biological targeted hyperthermia control method for tumor treatment, such as Figure 2 As shown, including:

[0090] D1. preparing a set amount of the aforementioned heat-sensitive fluid according to the shape and size of the tumor tissue in the body of the treatment subject;

[0091] D2. Injecting the thermosensitive fluid into the body circulatory system of the subject and maintaining the thermosensitive fluid for a set time to ensure that the thermosensitive substance in the thermosensitive fluid is enriched in the target tumor tissue or cells;

[0092] D3, placing the treatment object in a microwave radiation field of a set radiation intensity, monitoring and gradually adjusting the microwave radiation intensity so that the temperature of the thermosensitive fluid is maintained at a set value and lasts for a set time;

[0093] D4. Separate the treatment object from the microwave radiation field and the treatment is completed.

[0094] By repeating the above-mentioned thermal therapy process, the tumor tissue can be accurately identified by using the treatment object antibodies in the heat-sensitive fluid, and the heat-sensitive object can be sent to the tumor tissue. The microwave radiation in the microwave radiation field makes the heat-sensitive object heat up, and the tumor tissue is heated to the set temperature and maintained for the set time, and finally the tumor tissue or cells are killed. The whole process is non-invasive and will not cause damage to the normal tissue cells of the treatment object.

[0095] The above is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments. All technical solutions under the concept of the present invention belong to the protection scope of the present invention. It should be pointed out that for ordinary technicians in this technical field, some improvements and modifications without departing from the principle of the present invention should also be regarded as the protection scope of the present invention.

Claims

1. A biological targeted hyperthermia device for tumor treatment, characterized in that: include: A thermosensitive fluid intake device (1) configured to inject a thermosensitive fluid into the body circulatory system of a subject; A microwave radiation device (2) configured to provide a microwave radiation field having a set wavelength and frequency; A microwave imaging temperature measuring device (3) is configured to detect the temperature and location of a heat-sensitive fluid in a body of a treatment subject and output a thermal imaging signal; A control device (4) is configured to be signal-connected to the microwave imaging temperature measuring device (3) and control-connected to the microwave radiating device (2), receive the thermal imaging signal, and control the microwave radiating device (2) to output microwave radiation of a set wavelength and frequency; The biological targeted hyperthermia device further comprises a hyperthermia scheme generating device (8) configured to: A tumor tissue imaging acquisition unit (9) is used to automatically collect or receive external input information to generate the shape, size and position coordinates of the tumor tissue in the body of the treatment object; A thermosensitive fluid dosage generating unit (10) is configured to be signal-connected to the tumor tissue imaging acquiring unit (9), and to generate and output thermosensitive fluid dosage information based on a set algorithm according to the shape, size and position coordinates of the tumor tissue; The microwave radiation parameter generating unit (11) is configured to be signal-connected to the tumor tissue imaging acquiring unit (9) and to generate and output microwave radiation parameter information according to the tumor tissue shape and size, position coordinates and thermosensitive fluid dosage information.

2. The biological targeted hyperthermia device for tumor treatment according to claim 1, characterized in that: The biological targeted thermal therapy device also includes a fixing device (5) for adjusting the position of the body of the treatment object in the microwave radiation field.

3. The biological targeted hyperthermia device for tumor treatment according to claim 2, characterized in that: The retaining device (5) comprises: A bed (6) is disposed in the microwave radiation field and is configured to provide a stable support structure for the treatment object; The bed body (6) driving member is configured to be controllably connected to the control device (4) and is used to drive and change the position of the bed body (6) in three-dimensional space.

4. The biological targeted hyperthermia device for tumor treatment according to claim 1, characterized in that: The biological targeted thermal therapy device also includes a thermosensitive fluid flow direction monitoring device (12), which is configured to be signal-connected to the microwave imaging temperature measurement device (3), receive the thermal imaging signal of the thermosensitive fluid, and generate and output the flow path and enrichment area information of the thermosensitive fluid.

5. The biological targeted hyperthermia device for tumor treatment according to claim 1, characterized in that: The biological targeted hyperthermia device also includes: a safety monitoring device (13) configured to be connected to the microwave imaging temperature measuring device (3) by signal, receive the thermal imaging signal of the thermosensitive fluid, analyze the temperature of the thermosensitive fluid and compare it with a set value, and output an alarm signal to the control device (4) if the temperature exceeds the set range; A safety execution device (14) is configured in the control device (4), receives the alarm signal, and outputs an internal control signal to control the control device (4) to adjust the output of the microwave radiation device (2).

6. The biological targeted hyperthermia device for tumor treatment according to claim 1, characterized in that: The microwave radiation device (2) comprises a plurality of microwave radiators (15) arranged on a mounting bracket (16); the plurality of microwave radiators (15) are slidably arranged on the mounting bracket (16) and are connected to an external microwave source and a power regulation module.

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