cosmetic

Abstract

The object of the present invention is to provide cosmetics having a high preservative effect against both fungi and bacteria. In addition, the object of the present invention is to provide cosmetics that do not contain preservatives. The cosmetics of the present invention are characterized in that they contain (A) a fatty acid glyceride having 8 to 12 carbon atoms and (B) a specific acetophenone derivative. In addition, the present invention relates to a method for improving the preservative ability against fungi and bacteria, which comprises: adding the component (A) and the component (B) to a preservative object such as a cosmetic.

Description

Technical Field

[0001] The present invention relates to cosmetics having a high preservative effect. Background Art

[0002] Since cosmetics are used for a long time after opening, it is indispensable to have an antiseptic effect for inhibiting the growth and reproduction of microorganisms. Therefore, parabens such as methylparaben and ethylparaben, and preservatives such as phenoxyethanol are usually added to cosmetics. However, in recent years, with the improvement of safety awareness, there is a tendency to prefer additive-free cosmetics even in cosmetics, and cosmetics without preservatives as one of the additives are required. Therefore, a technology for giving cosmetics an antiseptic effect has been developed to replace the previous cosmetic preservatives.

[0003] Medium chain fatty acid glycerides and sucrose fatty acid esters are highly safe and have been proposed as substances with antibacterial effects. However, if a large amount of them is added to obtain a high antibacterial effect, it may cause irritation to the skin. In addition, although they have an antibacterial effect on yeast and bacteria, they have a weak antibacterial effect on molds, making it difficult to provide a broad-spectrum antibacterial cosmetic.

[0004] Patent Document 1 describes that a skin external preparation having an antiseptic and antibacterial effect can be obtained by combining (A) 0.2 mass % or more of n-hexyl 2,2-bis(hydroxymethyl)propionate and (B) one or more selected from a polyol having 3 to 9 carbon atoms, an alkyl glyceryl ether having 6 to 8 carbon atoms, and a fatty acid glyceride having 8 to 12 carbon atoms in a specific ratio.

[0005] In addition, diols such as dipropylene glycol and 1,3-butylene glycol are highly safe moisturizers and are widely used in cosmetics. They are also known to have antibacterial effects. However, in order to obtain a high antibacterial effect, such diols must be added in large quantities to cosmetics, which may cause the cosmetics to feel sticky.

[0006] Therefore, as a substance that imparts an antiseptic effect to cosmetics, a substance that can achieve a broad-spectrum antibacterial effect without hindering the usability of the cosmetics is required.

[0007] Prior art literature

[0008] Patent Literature

[0009] Patent Document 1: Japanese Patent Application Publication No. 2011-46747 Summary of the invention

[0010] Problem that the invention aims to solve

[0011] An object of the present invention is to provide a cosmetic having a high antiseptic effect against fungi and bacteria.

[0012] Solutions for solving problems

[0013] The inventors have conducted intensive studies to solve the above problems and have found that a combination of a certain fatty acid glyceride and a specific acetophenone derivative exhibits a high antiseptic effect on both fungi and bacteria, thereby completing the present invention.

[0014] That is, the present invention provides a cosmetic comprising:

[0015] (A) fatty acid glycerides having 8 to 12 carbon atoms and

[0016] (B) An acetophenone derivative represented by the following formula (1):

[0017]

[0018] (Where R 1 and R 2 each independently represents hydrogen, hydroxy or methoxy).

[0019] Effects of the Invention

[0020] According to the above configuration, the cosmetics of the present invention can obtain cosmetics with high antiseptic effects against fungi and bacteria. According to the above components (A) and (B), sufficient antiseptic effects can be obtained, so there is no need to add a large amount of diols and lower alcohols to obtain antiseptic effects, and cosmetics with good feel of use without stickiness and irritation to the skin can be obtained. In addition, cosmetics that do not contain preservatives used in general cosmetics, that is, "preservative-free" cosmetics can be achieved. DETAILED DESCRIPTION

[0021] The cosmetic of the present invention is characterized by containing (A) a fatty acid glyceride having 8 to 12 carbon atoms and (B) a specific acetophenone derivative. By combining the above-mentioned components (A) and (B), the cosmetic has an antiseptic effect. Hereinafter, each component constituting the cosmetic of the present invention is described in detail.

[0022] <(A) Fatty acid glycerides>

[0023] The (A) fatty acid glyceride (hereinafter sometimes referred to as "(A) component") formulated in the cosmetics of the present invention is a fatty acid glyceride having 8 to 12 carbon atoms and generally formulated in cosmetics. Examples thereof include glyceryl caprylate, glyceryl (2-ethylhexanoate), glyceryl caprate, glyceryl undecylenate, glyceryl laurate, and the like. In the cosmetics of the present invention, as the (A) component, one or more of the above-mentioned fatty acid glycerides may be used in combination. In the present invention, glyceryl caprate is preferably used, and glyceryl monocaprate is more preferably used.

[0024] The lower limit of the amount of component (A) relative to the total amount of the cosmetic is preferably 0.01% by mass or more or 0.05% by mass, and the upper limit is preferably 0.4% by mass or less or 0.3% by mass. Thus, as preferred ranges of the amount, 0.01 to 0.4% by mass, 0.01 to 0.3% by mass, 0.05 to 0.4% by mass, 0.05 to 0.3% by mass, etc. may be cited. When the amount is less than 0.01% by mass, sufficient antiseptic and antibacterial effects may not be obtained, and when the amount exceeds 0.4% by mass, the skin may feel irritated.

[0025] <(B) Acetophenone derivatives>

[0026] The (B) acetophenone derivative (hereinafter sometimes referred to as "component (B)") contained in the cosmetic of the present invention is an acetophenone derivative commonly contained in cosmetics, and is a compound represented by the following formula (1) or a salt thereof.

[0027]

[0028] In the above formula, R 1 and R 2 Each independently represents hydrogen, hydroxyl or methoxy, R 1 and R 2 It is arranged at the ortho-position, meta-position or para-position relative to the acetyl group.

[0029] In the present invention, one or more selected from the group consisting of the following compounds are preferred.

[0030] Acetophenone

[0031]

[0032] 2-Hydroxyacetophenone

[0033]

[0034] 3-Hydroxyacetophenone

[0035]

[0036] 4-Hydroxyacetophenone

[0037]

[0038] Among them, in the present invention, 4-hydroxyacetophenone is more preferred.

[0039] The salt of the compound represented by the above formula (1) may be any salt that is cosmetically acceptable or pharmaceutically acceptable, and examples thereof include sodium salts, potassium salts, and ammonium salts.

[0040] The amount of component (B) is preferably 0.06% by mass or more or 0.1% by mass or more relative to the total amount of the cosmetic, and the upper limit is preferably 2.0% by mass or less or 1.0% by mass or less. Thus, preferred ranges of the amount include 0.06 to 2.0% by mass, 0.06 to 1.0% by mass, 0.1 to 2.0% by mass, 0.1 to 1.0% by mass, etc. When the amount is less than 0.06% by mass, sufficient antiseptic and antibacterial effects may not be obtained, and when the amount is greater than 2.0% by mass, the skin may feel irritated.

[0041] In this specification, "antibacterial" means inhibiting the proliferation of bacteria on the surface of an object, and "antiseptic" means inhibiting the invasion, growth, and proliferation of microorganisms to prevent corruption and fermentation. Therefore, the "antiseptic effect" or "antiseptic action" of the present invention refers to the effects of both "antibacterial" and "antiseptic". When the object is cosmetics, it means inhibiting the proliferation of fungi such as bacteria, yeast and mold in cosmetics, preventing the deterioration of cosmetics due to bacteria, and improving the preservation of cosmetics.

[0042] During the research of the present invention, it was known that fatty acid glycerides have a strong antiseptic effect on yeast and bacteria, but a weak antiseptic effect on molds, while acetophenone derivatives have a strong antiseptic effect on molds, but a weak antiseptic effect on yeast and bacteria. On the other hand, phenoxyethanol, which is generally used in cosmetics as a preservative, has a strong antiseptic effect on Pseudomonas aeruginosa, but a poor antiseptic effect on other bacteria, yeast and molds. Therefore, when phenoxyethanol and fatty acid glycerides are combined, although the antiseptic effect on many microorganisms is improved, it is known that part of the partial antiseptic effect of the two alone is offset, that is, the killing rate of molds is significantly slowed down.

[0043] In the present invention, by combining fatty acid glyceride and acetophenone derivative, a high antiseptic effect can be obtained against all molds, yeasts and bacteria without canceling each other's advantages, and a novel combination having a broad antibacterial spectrum can be realized.

[0044] For the fatty acid glyceride of the present invention, Patent Document 1 describes that the combination with 2,2-bis(hydroxymethyl)propionic acid n-hexyl ester shows an antiseptic and antibacterial effect. In addition, for the acetophenone derivative of the present invention, Patent Document 2 (Japanese Patent Laid-Open No. 2018-90579) describes that the combination of acylamino acids such as acylproline (for example, decanoylproline), acylglycine (for example, octanoylglycine, undecenoylglycine) and polyols shows an antiseptic effect on bacteria and fungi.

[0045] On the other hand, in the present invention, since the (A) fatty acid glyceride and the (B) specific acetophenone derivative are combined to exert an antiseptic effect, it is not necessary to add acylamino acids such as 2,2-bis(hydroxymethyl)propionate, acylproline (for example, decanoylproline) and acylglycine (for example, octanoylglycine and undecenoylglycine) described in Patent Documents 1 and 2. Therefore, the present invention includes an embodiment that does not contain 2,2-bis(hydroxymethyl)propionate and / or acylamino acids.

[0046] The cosmetics of the present invention may be formulated with various ingredients commonly used in cosmetics. For example, the cosmetics may include hydrocarbon oils, higher fatty acids, higher alcohols, synthetic ester oils, silicone oils, liquid oils, solid oils, waxes and other oils commonly used in cosmetics, UV protection agents, oil phase thickeners, surfactants, water, lower alcohols, polyols, water-soluble polymers, humectants, powders, colorants, fragrances, neutralizers, chelating agents, pH adjusters, vitamins, antioxidants, drugs, etc., as needed.

[0047] In the present invention, sufficient preservative effects can be obtained by the aforementioned (A) fatty acid glyceride and the aforementioned (B) acetophenone derivative, and therefore, phenoxyethanol and parabens, which are generally used as preservatives in cosmetics, do not need to be added. Therefore, the present invention includes an embodiment that does not contain phenoxyethanol and / or parabens. According to the present invention, cosmetics that do not contain preservatives, that is, "preservative-free" cosmetics can be achieved.

[0048] In order to impart an antiseptic effect to cosmetics, diols such as dipropylene glycol and 1,3-butylene glycol are sometimes added in an amount greater than 10% by mass relative to the total amount of the cosmetics. According to the present invention, sufficient antiseptic effects can be obtained by using the aforementioned (A) fatty acid glyceride and the aforementioned (B) acetophenone derivative, so it is possible to set the amount of diol added to 10% by mass or less. Therefore, the present invention includes an embodiment in which the amount of diol added is 10% by mass or less. By reducing the amount of diol added, cosmetics having a non-sticky feel can be obtained.

[0049] In addition, the amount of lower alcohols such as ethanol has been increased to obtain an antibacterial effect. According to the present invention, sufficient antiseptic effect can be obtained by the aforementioned (A) fatty acid glyceride and the aforementioned (B) acetophenone derivative, so the amount of lower alcohol can be set to 3% by mass or less. Thus, the present invention includes a method in which the amount of lower alcohols such as ethanol is less than 10% by mass or less than 3% by mass and a method in which no lower alcohol is used. By reducing the amount of lower alcohols, a cosmetic that fully suppresses irritation to the skin can be obtained.

[0050] If the fatty acid glyceride (A) and the specific acetophenone derivative (B) of the present invention are combined with an object, the combined object shows excellent antiseptic ability against bacteria, yeast, molds and other fungi. Therefore, according to the present invention, the antiseptic object is combined with the component (A) and the component (B) of the present invention, so that the antiseptic ability of the antiseptic object against bacteria and fungi can be improved. Here, the antiseptic object is not limited to cosmetics, and examples thereof include skin external preparations such as ointments, perfumes, colognes and other scented products, daily hygiene products such as sweat wipes, and infant hygiene products such as hip wipes.

[0051] That is, the present invention relates to a method for improving the antiseptic ability against fungi and bacteria, comprising:

[0052] (A) a fatty acid glyceride having 8 to 12 carbon atoms and (B) an acetophenone derivative represented by the following formula (1) are blended into an object to be preserved.

[0053]

[0054] (Where R 1 and R 2 Each independently represents hydrogen, hydroxyl or methoxy. )

[0055] In the present invention, the object to be preserved is preferably a cosmetic.

[0056] In the above method, the components (A) and (B) of the present invention may be added to the finished product of the anticorrosion object, or may be mixed with the components (A) and (B) of the present invention during the process of manufacturing the anticorrosion object. The components (A) and (B) may be mixed at the same time or separately. When mixed separately, either the components (A) or (B) is mixed first.

[0057] The dosage form of the cosmetic of the present invention is not particularly limited, and any dosage form of a common cosmetic may be used, that is, liquid, gel, paste, emulsion, cream, spray, etc. may be used.

[0058] The cosmetics of the invention are not particularly limited, and can be formulated into skin care cosmetics such as lotions and moisturizing creams, makeup cosmetics such as foundations, BB creams, eye shadows, and lipsticks, sunscreen cosmetics, and poultices.

[0059] In addition, the present invention has an antiseptic effect against fungi and bacteria by combining the aforementioned (A) fatty acid glyceride and the aforementioned (B) acetophenone derivative. Therefore, according to the present invention, a broad-spectrum antibacterial composition having antifungal and bacterial effects can be obtained. That is, the present invention relates to an antiseptic composition comprising: (A) a fatty acid glyceride having 8 to 12 carbon atoms and (B) an acetophenone derivative represented by the following formula (1).

[0060]

[0061] (Where R 1 and R 2 Each independently represents hydrogen, hydroxyl or methoxy. )

[0062] Example

[0063] The present invention is further described in detail by the following examples, but the present invention is not limited to these examples. Unless otherwise specified, the amount of the component is expressed as the mass % of the component relative to the system in which it is mixed. Before describing each example in detail, the test method and evaluation method used are described.

[0064] According to a conventional method, lotions of Test Examples 1 to 5 having the compositions shown in Table 1 were prepared, and an antiseptic effect test and a use test were carried out.

[0065] <Anticorrosion effect test>

[0066] 1. Fungi of the test subject

[0067] Ps: Pseudomonas aeruginosa (strain name: Pseudomonas aeruginosa, ATCC15442)

[0068] E: Escherichia coli (strain name: Escherichia coli, ATCC8739)

[0069] S: Staphylococcus aureus (strain name: Staphylococcus aureus, ATCC6538)

[0070] Can: Candida albicans (yeast) standard strain (strain name: Candida albicans, ATCC10231)

[0071] Asp: Aspergillus brasiliensis (strain name: Aspergillus brasiliensis, ATCC16404)

[0072] 2. Experiment

[0073] The antiseptic ability evaluation method test was carried out according to the method based on ISO11930, and the antiseptic ability against bacteria and fungi was evaluated based on the log reduction value (LRV: Log Reduction Value) obtained by the following formula.

[0074] LRV = log10 (viable bacterial concentration on day 0 / viable bacterial concentration at the time of sampling)

[0075] 3. Evaluation

[0076] The anticorrosion effect was evaluated based on the following criteria, and only those with A were judged to have sufficient anticorrosion ability.

[0077] Evaluation criteria for the anti-corrosion effect on Ps, E, and S

[0078] A: LRV is 3 or more after 7 days.

[0079] B: It takes 8 to 14 days for LRV to reach 3 or above.

[0080] C: After more than 14 days, the LRV is less than 3.

[0081] Evaluation criteria for the anti-corrosion effect of Can

[0082] A: LRV is 1 or more after 7 days.

[0083] B: It takes 8 to 14 days for LRV to reach 1 or above.

[0084] C: After more than 14 days, the LRV is still less than 1.

[0085] Evaluation criteria for the antiseptic effect on Asp

[0086] A: LRV is 1 or more after 14 days.

[0087] B: It takes 15 to 28 days for LRV to reach 1 or above.

[0088] C: After more than 28 days, the LRV is still less than 1.

[0089] <Usability test>

[0090] Ten panelists were asked to use the product twice a day for one week and report their satisfaction with the product and the presence or absence of skin irritation. The evaluation of the feeling of use was divided into the following four levels, and the number of people who reported a sense of irritation was also checked.

[0091] A: More than 8 panelists think that there is no skin irritation and the feeling of use is good

[0092] B: 5 or more but less than 8 panelists believe that the product has no skin irritation and is good when used.

[0093] C: 3 or more but less than 5 panelists think that the product has no skin irritation and feels good when used.

[0094] D: Less than 3 panelists believe that there is no skin irritation and the experience is good

[0095] According to a conventional method, lotions (Test Examples 1 to 5) having the compositions described in Table 1 below were prepared. According to the above-mentioned test and evaluation methods, the antiseptic effect on each fungus was evaluated.

[0096] [Table 1]

[0097] Test Example 1 Test Example 2 Test Example 3 Test Example 4 Test Example 5 Ion exchange water margin margin margin margin margin glycerin 5 5 5 5 5 1,3-Butanediol 6 6 6 6 6 Erythritol 1 1 1 1 1 PPG-6-decyltetradecanol polyether-12 0.2 0.2 0.2 0.2 0.2 Phenoxyethanol 0.5 - 0.5 0.5 - Glyceryl Monocaprate - - 0.2 0.1 0.1 4-Hydroxyacetophenone - 0.5 - - 0.5 Citric acid Moderate Moderate Moderate Moderate Moderate Sodium Citrate Moderate Moderate Moderate Moderate Moderate Anticorrosion effect on Ps A A A A A Anticorrosive effect on E B A A A A Anticorrosion effect on S C C A A A Antiseptic effect on Can B B A A A Antiseptic effect on Asp B A C C A Usage A A A A A Skin irritation A A A A A

[0098] As shown in Table 1, the lotion (Test Example 1) containing phenoxyethanol, which has been used as a preservative, has a high preservative effect on Pseudomonas aeruginosa (Ps), a moderate preservative effect on Escherichia coli (E), Candida albicans (Can) and Aspergillus brasiliensis (Asp), and a weak preservative effect on Staphylococcus aureus (S). The lotion (Test Example 2) containing 4-hydroxyacetophenone as an acetophenone derivative has a strong preservative effect on Ps, E and Asp, a moderate preservative effect on Can, and a weak preservative effect on S. In addition, the lotion (Test Example 3, Test Example 4) formed by combining and blending glyceryl monocaprate as a fatty acid glyceride and phenoxyethanol, compared with the case of phenoxyethanol alone (Test Example 1), has an improved preservative effect on E, S and Can, but a slower killing rate of Asp, and a significantly reduced preservative effect on mold. This shows that when fatty acid glyceride is combined with phenoxyethanol, part of the preservative effect of phenoxyethanol is offset.

[0099] On the other hand, the lotion prepared by combining and blending the fatty acid glyceride of the present invention and the acetophenone derivative (Test Example 5) showed a sufficient antiseptic effect on all of Ps, E, S, Can, and Asp.

Claims

1. A cosmetic comprising: (A) glyceryl monocaprate, and (B) 4-hydroxyacetophenone, Also, it does not contain phenoxyethanol, acyl proline, and parabens.

2. The cosmetic according to claim 1, wherein The amount of the component (A) is not more than 0.4% by mass based on the total amount of the cosmetic.

3. A method for improving the antiseptic ability of cosmetics against fungi and bacteria, comprising: Formulated in cosmetics that do not contain phenoxyethanol, acyl proline, or parabens (A) glyceryl monocaprate, and (B) 4-Hydroxyacetophenone.

4. A preservative composition for preserving cosmetics that do not contain phenoxyethanol, acyl proline and parabens, the preservative composition comprising: (A) glyceryl monocaprate, and (B) 4-Hydroxyacetophenone.

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