A microfluidic channel, a microfluidic chip and its application

Abstract

The present invention discloses a microfluidic channel, a microfluidic chip and its application. The microfluidic chip comprises a first base chip, a dispersed phase fluid distribution layer, a droplet generation layer, a continuous phase fluid distribution layer and a second base chip which are bonded in sequence; one side of the first base chip is bonded to the front side of the dispersed phase fluid distribution layer, the back side of the dispersed phase fluid distribution layer is bonded to the front side of the droplet generation layer, the back side of the droplet generation layer is bonded to the back side of the continuous phase fluid distribution layer, and the front side of the continuous phase fluid distribution layer is bonded to one side of the second base chip; the droplet generation layer is provided with a second rectangular flow channel, a third rectangular flow channel, a plurality of cross-shaped flow channels, a plurality of fifth cylindrical flow channels, an outlet rectangular branch and an outlet rectangular main road. The microfluidic chip of the present invention has a reasonable flow channel layout, high unit integration, high droplet productivity and uniform size.

Description

Technical Field

[0001] The invention relates to a microfluidic channel, a microfluidic chip and applications thereof. Background Art

[0002] Microfluidic chips can produce highly monodisperse droplets by precisely controlling microfluidics, and are widely used in biological analysis, material synthesis, cosmetics, food and other fields. Although microfluidic chips have significant advantages in producing droplets, the low productivity of microfluidic chips is still one of the key challenges that restrict the transformation of laboratory-scale droplet production to commercial scale. A promising development direction for expanding production is to perform parallel integration based on the optimization of the droplet production unit structure to form a microfluidic network and improve the production capacity of a single chip. Wei Li, Edmond WKY, Minseok S, et al. Simultaneous generation of droplets with different dimensions in parallel integrated microfluidic droplet generators [J]. Soft matter, 2008, 4 (2): 258-262 discloses a four-unit parallel microfluidic chip for high-throughput production of droplets, but its droplet production unit structure is relatively simple, the channel network has low unit integration, and the flow channel layout is unreasonable, which has become a potential limiting factor affecting the high-throughput production of monodisperse droplets. Summary of the invention

[0003] The present invention provides a microfluidic channel, a microfluidic chip and its application in order to overcome the defects of the prior art microfluidic chip such as low unit integration and unreasonable flow channel layout which makes it difficult to expand production. The microfluidic chip of the present invention has a reasonable flow channel layout, high unit integration, high droplet productivity and uniform size.

[0004] The present invention solves the above technical problems through the following technical solutions.

[0005] The present invention provides a microfluidic channel, which includes a dispersed phase flow channel, a continuous phase flow channel, an outlet rectangular branch and an outlet rectangular main channel;

[0006] The dispersed phase flow channel includes a plurality of cylindrical flow channels, a plurality of rectangular flow channels and a plurality of cross-shaped flow channels;

[0007] The first cylindrical flow channel is vertically connected to the center of the first rectangular flow channel;

[0008] Two ends of the first rectangular flow channel are respectively connected to the second rectangular flow channel and the third rectangular flow channel through a second cylindrical flow channel and a third cylindrical flow channel which are perpendicular to the first rectangular flow channel;

[0009] The second rectangular flow channel and the third rectangular flow channel are located on the same plane and are parallel to each other;

[0010] The second cylindrical flow channel and the third cylindrical flow channel are respectively arranged perpendicular to the second rectangular flow channel and the third rectangular flow channel;

[0011] The projection of the first rectangular flow channel on the plane where the second rectangular flow channel and the third rectangular flow channel are located is respectively perpendicular to the second rectangular flow channel and the third rectangular flow channel;

[0012] A plurality of cross-shaped flow channels are vertically arranged on both sides of the second rectangular flow channel and the third rectangular flow channel;

[0013] Each of the cross-shaped flow channels is located on the plane where the second rectangular flow channel and the third rectangular flow channel are located;

[0014] The vertical flow channels of the cross-shaped flow channel are arranged alternately on both sides of the second rectangular flow channel and the third rectangular flow channel;

[0015] The continuous phase flow channel includes a plurality of cylindrical flow channels, an I-shaped flow channel and a plurality of terminal flow channels;

[0016] The fourth cylindrical flow channel is vertically connected to the center of the I-shaped flow channel;

[0017] A plurality of terminal flow channels perpendicular to the horizontal sides of the I-shaped flow channel are arranged alternately on both sides of the two horizontal sides of the I-shaped flow channel;

[0018] The plurality of terminal flow channels are arranged in a staggered manner along the lateral sides of the I-shaped flow channel;

[0019] The I-shaped flow channel and the plurality of terminal flow channels are located on the same plane;

[0020] The distal end of each of the distal flow channels is vertically connected to a cross flow channel of the cross-shaped flow channel through a fifth cylindrical flow channel;

[0021] Two adjacent cross flow channels are connected through a fifth cylindrical flow channel;

[0022] The outer side of the second rectangular flow channel, between the second rectangular flow channel and the third rectangular flow channel, and the outer side of the third rectangular flow channel are respectively provided with mutually parallel outlet rectangular branches;

[0023] Each of the outlet rectangular branches is vertically connected to the vertical flow channel on the same side;

[0024] Both ends of each of the outlet rectangular branches are vertically connected to an outlet rectangular main road;

[0025] The outlet rectangular branch and the outlet rectangular main path are both located on the plane where the second rectangular flow channel and the third rectangular flow channel are located.

[0026] In the present invention, each of the cross-shaped flow channels is a droplet generation unit. Wherein, a continuous phase fluid flows into the two ends of the transverse flow channel, and a dispersed phase fluid flows into the connection between the vertical flow channel and the second rectangular flow channel or the third rectangular flow channel. The continuous phase fluid and the dispersed phase fluid interact or shear and squeeze at the intersection of the transverse flow channel and the vertical flow channel to generate monodisperse droplets. The present invention improves the integration and parallel number of droplet generation units by rationally arranging microfluidic flow channels. Adjacent generation units share the second rectangular flow channel or the third rectangular flow channel, which reduces unnecessary flow channels. The droplet generation frequency is highly stable and can be used for high-throughput production of droplets. The multiple cylindrical flow channels and the multiple rectangular flow channels in the dispersed phase flow channel, as well as the multiple cylindrical flow channels, the multiple cylindrical flow channels, the I-shaped flow channels and the multiple terminal flow channels in the continuous phase flow channel are arranged to distribute fluid to each cross-shaped flow channel, thereby improving the distribution efficiency of the working fluid and reducing the resistance loss along the distribution of the working fluid to each cross-shaped flow channel.

[0027] In the present invention, preferably, the cross-sections of the horizontal flow channel and the vertical flow channel are both rectangular.

[0028] More preferably, the cross-shaped flow channel is composed of the transverse flow channel, the vertical flow channel and an intersection area, the transverse flow channel and the vertical flow channel are both straight flow channels, and the intersection area is octagonal (i.e., there is a gradually expanding area). Such a setting makes the droplet generation frequency faster and the droplet size more uniform.

[0029] In the present invention, both ends of the second rectangular flow channel and the third rectangular flow channel are not connected to the cross-shaped flow channel.

[0030] In the present invention, preferably, the cross-section of the I-shaped flow channel is rectangular.

[0031] In the present invention, preferably, the cross section of the distal flow channel is rectangular.

[0032] The present invention also provides a microfluidic chip, which comprises a first base chip, a dispersed phase fluid distribution layer, a droplet generation layer, a continuous phase fluid distribution layer and a second base chip which are sequentially bonded;

[0033] Wherein, one side of the first base chip is attached to the front side of the dispersed phase fluid distribution layer, the back side of the dispersed phase fluid distribution layer is attached to the front side of the droplet generation layer, the back side of the droplet generation layer is attached to the back side of the continuous phase fluid distribution layer, and the front side of the continuous phase fluid distribution layer is attached to one side of the second base chip;

[0034] The first base chip is provided with the first cylindrical flow channel as mentioned above;

[0035] The dispersed phase fluid distribution layer is provided with the first rectangular flow channel as mentioned above, the second cylindrical flow channel as mentioned above and the third cylindrical flow channel as mentioned above;

[0036] The droplet generation layer is provided with the second rectangular flow channel as described above, the third rectangular flow channel as described above, a plurality of cross-shaped flow channels as described above, a plurality of fifth cylindrical flow channels as described above, the outlet rectangular branch as described above, and the outlet rectangular main path as described above;

[0037] The continuous phase fluid distribution layer is provided with the aforementioned I-shaped flow channel and a plurality of aforementioned terminal flow channels;

[0038] The second base chip is provided with the fourth cylindrical flow channel as mentioned above.

[0039] In the present invention, preferably, the droplet generation layer includes one of the second rectangular flow channels, one of the third rectangular flow channels, 28 of the cross flow channels, 36 of the fifth cylindrical flow channels (corresponding to the 36 terminal flow channels of the continuous phase fluid distribution layer), three of the outlet rectangular branches and two of the outlet rectangular main channels.

[0040] In the present invention, preferably, the microfluidic chip is made of polymethyl methacrylate (PMMA) material.

[0041] In the present invention, preferably, the layers of the microfluidic chip are sealed by thermal compression bonding.

[0042] The present invention also provides a use of the aforementioned microfluidic channel or the aforementioned microfluidic chip in producing monodisperse droplets.

[0043] The positive and progressive effects of the present invention are:

[0044] The present invention improves the integration and parallel number of droplet generation units by rationally arranging microfluidic channels. Adjacent generation units share the second rectangular channel or the third rectangular channel, which reduces unnecessary channels and improves the integration of droplet units, and can be used for high-throughput production of droplets. The dispersed phase fluid distribution layer and the continuous phase fluid distribution layer are used to distribute fluid to the droplet generation layer, which improves the distribution efficiency of the working fluid and reduces the resistance loss along the way when it is distributed to each droplet generation unit. BRIEF DESCRIPTION OF THE DRAWINGS

[0045] Figure 1 Schematic diagram of stacking layers in the microfluidic chip of Example 1.

[0046] Figure 2Schematic diagram of the first base layer chip or the second base layer chip of Example 1.

[0047] Figure 3 Schematic diagram of the dispersed phase fluid distribution layer of Example 1.

[0048] Figure 4 Schematic diagram of the droplet generation layer of Example 1.

[0049] Figure 5 Schematic diagram of the intersection area of ​​the cross-shaped flow channel of Example 1.

[0050] Figure 6 Schematic diagram of the continuous phase fluid distribution layer of Example 1.

[0051] Figure 7 Schematic diagram of simulation analysis results of Examples 1 and 2.

[0052] Description of Reference Numerals

[0053] First base chip 1

[0054] Dispersed phase fluid distribution layer 2

[0055] Droplet generation layer 3

[0056] Continuous phase fluid distribution layer 4

[0057] Second base chip 5

[0058] The first cylindrical flow channel 101

[0059] The first rectangular flow channel 201

[0060] The second cylindrical flow channel 202

[0061] The third cylindrical flow channel 203

[0062] The second rectangular flow channel 301

[0063] The third rectangular flow channel 302

[0064] Cross channel 303

[0065] Vertical flow channel 304

[0066] Fifth cylindrical flow channel 305

[0067] Crossflow channel 306

[0068] Exit rectangular branch 307

[0069] Exit rectangular main road 308

[0070] Intersection 309

[0071] I-shaped runner 401

[0072] End channel 402

[0073] Fourth cylindrical flow channel 501 DETAILED DESCRIPTION

[0074] The present invention is further described below by way of examples, but the present invention is not limited to the scope of the examples.

[0075] Example 1

[0076] like Figures 1 to 6As shown, Example 1 provides a microfluidic channel, which includes a dispersed phase flow channel, a continuous phase flow channel, an outlet rectangular branch 307 and an outlet rectangular main path 308; the dispersed phase flow channel includes a plurality of cylindrical flow channels, a plurality of rectangular flow channels and a plurality of cross-shaped flow channels 303; the first cylindrical flow channel 101 is vertically connected to the center of the first rectangular flow channel 201; the two ends of the first rectangular flow channel 201 are respectively connected to the second rectangular flow channel 301 and the third rectangular flow channel 302 through the second cylindrical flow channel 202 and the third cylindrical flow channel 203 perpendicular to the first rectangular flow channel 201; the second rectangular flow channel 301 and the third rectangular flow channel 302 are located on the same plane and are opposite to each other. The second cylindrical flow channel 202 and the third cylindrical flow channel 203 are respectively arranged perpendicularly to the second rectangular flow channel 301 and the third rectangular flow channel 302; the projection of the first rectangular flow channel 201 on the plane where the second rectangular flow channel 301 and the third rectangular flow channel 302 are located is respectively perpendicular to the second rectangular flow channel 301 and the third rectangular flow channel 302; a plurality of cross-shaped flow channels 303 are respectively arranged perpendicularly on both sides of the second rectangular flow channel 301 and the third rectangular flow channel 302; each cross-shaped flow channel 303 is located on the plane where the second rectangular flow channel 301 and the third rectangular flow channel 302 are located; the projection of the first rectangular flow channel 201 on the plane where the second rectangular flow channel 301 and the third rectangular flow channel 302 are located is respectively perpendicular to the second rectangular flow channel 301 and the third rectangular flow channel 302. The vertical flow channel 304 is staggered with cross-shaped flow channels 303; the continuous phase flow channel includes a plurality of cylindrical flow channels, an I-shaped flow channel 401 and a plurality of terminal flow channels 402; the fourth cylindrical flow channel 501 is vertically connected to the center of the I-shaped flow channel 401; the two sides of the two horizontal sides of the I-shaped flow channel 401 are staggered with a plurality of terminal flow channels 402 perpendicular to the horizontal sides of the I-shaped flow channel 401; the plurality of terminal flow channels 402 are staggered along the horizontal sides of the I-shaped flow channel 401; the I-shaped flow channel 401 and the plurality of terminal flow channels 402 are located on the same plane; the distal end of each terminal flow channel 402 is connected to a cross-shaped flow channel through a fifth cylindrical flow channel 305 and a fifth cylindrical flow channel 306 respectively. The cross flow channels 306 of the channel 303 are vertically connected; two adjacent cross flow channels 306 are connected through a fifth cylindrical channel 305; the outer side of the second rectangular channel 301, between the second rectangular channel 301 and the third rectangular channel 302, and the outer side of the third rectangular channel 302 are respectively provided with mutually parallel outlet rectangular branches 307; each outlet rectangular branch 307 is vertically connected to the vertical flow channel 304 on the same side; both ends of each outlet rectangular branch 307 are vertically connected to an outlet rectangular main channel 308; the outlet rectangular branch 307 and the outlet rectangular main channel 308 are both located on the plane where the second rectangular channel 301 and the third rectangular channel 302 are located.

[0077] The cross-sections of the transverse flow channel 306 and the vertical flow channel 304 are both rectangular.

[0078] The cross-shaped flow channel 303 is composed of a transverse flow channel 306 , a vertical flow channel 304 and a junction area 309 . The transverse flow channel 306 and the vertical flow channel 304 are both straight flow channels, and the junction area 309 is in the shape of an octagon.

[0079] Both ends of the second rectangular flow channel 301 and the third rectangular flow channel 302 are not connected to the cross-shaped flow channel 303 .

[0080] The cross-section of the I-shaped flow channel 401 is rectangular.

[0081] The cross section of the distal flow channel 402 is rectangular.

[0082] Embodiment 1 also provides a microfluidic chip, which includes a first base chip 1, a dispersed phase fluid distribution layer 2, a droplet generation layer 3, a continuous phase fluid distribution layer 4, and a second base chip 5, which are sequentially bonded together; wherein one side of the first base chip 1 is bonded to the front side of the dispersed phase fluid distribution layer 2, the back side of the dispersed phase fluid distribution layer 2 is bonded to the front side of the droplet generation layer 3, the back side of the droplet generation layer 3 is bonded to the back side of the continuous phase fluid distribution layer 4, and the front side of the continuous phase fluid distribution layer 4 is bonded to one side of the second base chip 5; the first base chip 1 is provided with the first cylindrical flow channel 101 as described above; the dispersed phase fluid distribution layer 2 is provided with the The first rectangular flow channel 201, the second cylindrical flow channel 202 as described above, and the third cylindrical flow channel 203 as described above; the droplet generation layer 3 is provided with the second rectangular flow channel 301 as described above, the third rectangular flow channel 302 as described above, multiple cross-shaped flow channels 303 as described above, multiple fifth cylindrical flow channels 305 as described above, the outlet rectangular branch 307 as described above, and the outlet rectangular main path 308 as described above; the continuous phase fluid distribution layer 4 is provided with the I-shaped flow channel 401 as described above and multiple terminal flow channels 402 as described above; the second base chip 5 is provided with the fourth cylindrical flow channel 501 as described above.

[0083] In this embodiment, the droplet generation layer 3 has a second rectangular flow channel 301, a third rectangular flow channel 302, 28 cross-shaped flow channels 303, 36 fifth cylindrical flow channels 305 (corresponding to the continuous phase fluid distribution layer 4 having 36 terminal flow channels 402), three outlet rectangular branches 307 and two outlet rectangular main channels 308.

[0084] The working process of the microfluidic chip is as follows: each cross-shaped flow channel 303 is a droplet generation unit. After the dispersed phase fluid and the continuous phase fluid are pumped into the first cylindrical flow channel 101 of the first base chip 1 and the fifth cylindrical flow channel 305 of the second base chip 5 by using an injection pump or a pressure pump, they enter the dispersed phase fluid distribution layer 2 and the continuous phase fluid distribution layer 4, and enter each droplet generation unit along the connection relationship between the interlayer flow channels, wherein the continuous phase fluid flows into the two ends of the transverse flow channel 306, and the dispersed phase fluid flows into the connection between the vertical flow channel 304 and the second rectangular flow channel 301 or the third rectangular flow channel 302. The continuous phase fluid and the dispersed phase fluid interact or shear and squeeze at the intersection 309 of the transverse flow channel 306 and the vertical flow channel 304, and the dispersed phase fluid breaks into droplets, and the droplets enter the outlet rectangular main road 308, and are collected through the four outlets of the outlet rectangular main road 308, completing the entire workflow of the microfluidic chip.

[0085] The material of the microfluidic chip is polymethyl methacrylate (PMMA).

[0086] The layers of the microfluidic chip are sealed by thermal compression bonding.

[0087] Example 2

[0088] In Example 2, the cross-shaped flow channel 303 is composed of a transverse flow channel 306, a vertical flow channel 304 and an intersection area 309. The transverse flow channel 306 and the vertical flow channel 304 are both straight flow channels, and the intersection area 309 is in the shape of a quadrilateral (ie, there is no gradually expanding area).

[0089] Other technical solutions are the same as those in Example 1.

[0090] Effect Example 1

[0091] The cross-shaped flow channel 303 of Example 1 and Example 2 were simulated and analyzed under the same conditions, wherein the physical properties of the two-phase fluid (the density of the dispersed phase is 1.4*10 3 kg / m 3 , viscosity is 6.71*10 -3 Pa·s, the density of the continuous phase is 1*10 3 kg / m 3 , viscosity is 1*10 3 Pa·s), the flow rate ratio of the continuous phase to the dispersed phase is 3:2, and the contact angle is 0.349 rad). The results are as follows Figure 7 As shown, 1 is the simulation analysis result of Example 2, and 2 is the simulation analysis result of Example 1.

[0092] Depend on Figure 7 It can be seen that the droplet generation frequency of the cross-shaped flow channel of Example 1 is faster.

[0093] Although the specific embodiments of the present invention are described above, it should be understood by those skilled in the art that this is only for illustration and the protection scope of the present invention is defined by the appended claims. Those skilled in the art may make various changes or modifications to these embodiments without departing from the principles and essence of the present invention, but these changes and modifications all fall within the protection scope of the present invention.

Claims

1. A microfluidic channel, characterized in that: It includes a dispersed phase flow channel, a continuous phase flow channel, an outlet rectangular branch and an outlet rectangular main road; The dispersed phase flow channel includes a plurality of cylindrical flow channels, a plurality of rectangular flow channels and a plurality of cross-shaped flow channels; The first cylindrical flow channel is vertically connected to the center of the first rectangular flow channel; Two ends of the first rectangular flow channel are respectively connected to the second rectangular flow channel and the third rectangular flow channel through a second cylindrical flow channel and a third cylindrical flow channel which are perpendicular to the first rectangular flow channel; The second rectangular flow channel and the third rectangular flow channel are located on the same plane and are parallel to each other; The second cylindrical flow channel and the third cylindrical flow channel are respectively arranged perpendicular to the second rectangular flow channel and the third rectangular flow channel; The projection of the first rectangular flow channel on the plane where the second rectangular flow channel and the third rectangular flow channel are located is respectively perpendicular to the second rectangular flow channel and the third rectangular flow channel; A plurality of cross-shaped flow channels are vertically arranged on both sides of the second rectangular flow channel and the third rectangular flow channel; Each of the cross-shaped flow channels is located on the plane where the second rectangular flow channel and the third rectangular flow channel are located; The vertical flow channels of the cross-shaped flow channel are arranged alternately on both sides of the second rectangular flow channel and the third rectangular flow channel; The continuous phase flow channel includes a plurality of cylindrical flow channels, an I-shaped flow channel and a plurality of terminal flow channels; The fourth cylindrical flow channel is vertically connected to the center of the I-shaped flow channel; A plurality of terminal flow channels perpendicular to the horizontal sides of the I-shaped flow channel are arranged alternately on both sides of the two horizontal sides of the I-shaped flow channel; The plurality of terminal flow channels are arranged in a staggered manner along the lateral sides of the I-shaped flow channel; The I-shaped flow channel and the plurality of terminal flow channels are located on the same plane; The distal end of each of the distal flow channels is vertically connected to a cross flow channel of the cross-shaped flow channel through a fifth cylindrical flow channel; Two adjacent cross flow channels are connected through a fifth cylindrical flow channel; The outer side of the second rectangular flow channel, between the second rectangular flow channel and the third rectangular flow channel, and the outer side of the third rectangular flow channel are respectively provided with mutually parallel outlet rectangular branches; Each of the outlet rectangular branches is vertically connected to the vertical flow channel on the same side; Both ends of each of the outlet rectangular branches are vertically connected to an outlet rectangular main road; The outlet rectangular branch and the outlet rectangular main path are both located on the plane where the second rectangular flow channel and the third rectangular flow channel are located.

2. The microfluidic channel according to claim 1, characterized in that The cross sections of the transverse flow channel and the vertical flow channel are both rectangular.

3. The microfluidic channel according to claim 2, characterized in that: The cross-shaped flow channel is composed of the transverse flow channel, the vertical flow channel and a junction area. The transverse flow channel and the vertical flow channel are both straight flow channels, and the junction area is in the shape of an octagon.

4. The microfluidic channel according to claim 1, characterized in that: Both ends of the second rectangular flow channel and the third rectangular flow channel are not connected to the cross-shaped flow channel.

5. The microfluidic channel according to claim 1, characterized in that: The cross-sections of the I-shaped flow channels are all rectangular; The cross section of the distal flow channel is rectangular.

6. A microfluidic chip, characterized in that: It comprises a first base chip, a dispersed phase fluid distribution layer, a droplet generation layer, a continuous phase fluid distribution layer and a second base chip which are sequentially attached; Wherein, one side of the first base chip is attached to the front side of the dispersed phase fluid distribution layer, the back side of the dispersed phase fluid distribution layer is attached to the front side of the droplet generation layer, the back side of the droplet generation layer is attached to the back side of the continuous phase fluid distribution layer, and the front side of the continuous phase fluid distribution layer is attached to one side of the second base chip; The first base chip is provided with the first cylindrical flow channel as claimed in claim 1; The dispersed phase fluid distribution layer is provided with the first rectangular flow channel as claimed in claim 1, the second cylindrical flow channel as claimed in claim 1 and the third cylindrical flow channel as claimed in claim 1; The droplet generation layer is provided with the second rectangular flow channel as claimed in claim 1, the third rectangular flow channel as claimed in claim 1, a plurality of cross-shaped flow channels as claimed in claim 1, a plurality of fifth cylindrical flow channels as claimed in claim 1, the outlet rectangular branch as claimed in claim 1 and the outlet rectangular main road as claimed in claim 1; The continuous phase fluid distribution layer is provided with an I-shaped flow channel as claimed in claim 1 and a plurality of terminal flow channels as claimed in claim 1; The second base chip is provided with the fourth cylindrical flow channel as claimed in claim 1.

7. The microfluidic chip according to claim 6, characterized in that: The microfluidic chip is made of polymethyl methacrylate.

8. The microfluidic chip according to claim 6, characterized in that: The layers of the microfluidic chip are sealed by thermal compression bonding.

9. The microfluidic chip according to claim 6, characterized in that: The droplet generation layer includes one of the second rectangular flow channels, one of the third rectangular flow channels, 28 of the cross-shaped flow channels, 36 of the fifth cylindrical flow channels, three of the outlet rectangular branches and two of the outlet rectangular main channels.

10. Use of the microfluidic channel according to any one of claims 1 to 5 or the microfluidic chip according to any one of claims 6 to 9 in producing monodisperse droplets.

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