A preparation process of ten-flavor hand ginseng powder

Abstract

The present invention relates to a preparation process of a ten-flavor hand ginseng powder. The weight parts of each drug in the powder are: 2-15 parts of hand ginseng, 2-15 parts of cinnamon bark, 20-150 parts of cardamom, 10-60 parts of longan, 10-60 parts of asparagus, 10-60 parts of pomegranate seeds, 10-60 parts of sword beans, 10-60 parts of safflower, 1-6 parts of artificial musk, and 1-6 parts of bear gall. The finished product of the ten-flavor hand ginseng powder is obtained by drying, classifying, crushing, sterilizing, and compounding the above drugs. The powder is a core-shell-wrapped composite particle, which can effectively improve the retention rate of volatile components.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine preparations, and in particular to a preparation process of ten-flavor hand-ginseng powder. Background Art

[0002] Powders have a place in the history of traditional Chinese medicine because they are easy to take, but powders have a large specific surface area, the active ingredients in the preparations are easy to evaporate, and their hygroscopicity is also greater than other dosage forms, which will directly affect the quality of the powder.

[0003] Shiwei Shoushen Powder is a traditional Tibetan medicine prescription, which is composed of ten kinds of herbs, including ginseng, cinnamon bark, cardamom, longan, asparagus, pomegranate seeds, sword bean, safflower, artificial musk, bear bile, etc. It has the effects of tonifying the kidney and consolidating sperm, and is mainly used for kidney deficiency, spermatorrhea, and impotence. This prescription is composed of ten kinds of herbs, among which bear bile tastes extremely bitter. If the powder is prepared according to the traditional method, it will cause poor oral compliance; the artificial musk in the prescription is a precious herbal medicine with volatile active ingredients, and the retention rate of the active ingredients directly affects the efficacy of the drug.

[0004] Core-shell nanoparticles are widely used in the field of materials science. They have the advantages of both core and shell, and can be controlled to give them various properties. They are applied to the field of traditional Chinese medicine, using appropriate means to interfere with the interaction between drugs, and regulating the disordered traditional Chinese medicine powder system into stable and controllable component units, thereby achieving the purpose of improving the quality of traditional Chinese medicine powder.

[0005] However, the results obtained under the current background of core-shell nanoparticle technology are more like accidents favored by luck, rather than inevitability under the guidance of the technical system. Therefore, the inventors hereby propose a preparation process of Shiwei Shoushen powder, in which the shell particles are continuously adsorbed on the core particles under the action of van der Waals force and electrostatics, and core-shell wrapped composite particles can be selectively constructed, so that the traditional Chinese medicine core-shell nanoparticle technology changes from accidental to inevitable. Summary of the invention

[0006] The technical solution of the present invention is to provide a formula of ten-flavor hand ginseng powder and a preparation process thereof. The main purpose of the present invention is to overcome the deficiencies of the prior art and provide a formula of ten-flavor hand ginseng powder and a preparation process thereof, which can regulate the disordered ten-flavor hand ginseng powder system into stable and controllable component units, thereby improving the retention rate of the effective ingredients of the ten-flavor hand ginseng powder.

[0007] The present invention provides a preparation process of ten-flavor hand ginseng powder, comprising the following steps:

[0008] (1) Weighing: weigh the raw materials: ginseng, cinnamon bark, cardamom, longan, asparagus, pomegranate seeds, sword bean, safflower, artificial musk, and bear gall;

[0009] (2) Drying: Piper longum, asparagus cochinchinensis, pomegranate seeds, sword beans, safflower, cinnamon bark, cardamom, and ginseng are dried;

[0010] (3) Grinding: Mix five medicinal materials including Piper longum, Asparagus cochinchinensis, Pomegranate seeds, Sword bean and Safflower and grind them into ultrafine powder to obtain mixed powder A; Mix five medicinal materials including Cinnamon bark, Cardamom, Panax ginseng, Artificial musk and Bear gall and grind them into ultrafine powder to obtain mixed powder B;

[0011] (4) Sterilization: sterilize mixed powder A and mixed powder B respectively, and then dry them respectively until the moisture content is ≤7%;

[0012] (5) Compounding: Step 1: Mixed powder A is placed in a first pipe, and mixed powder B is placed in a second pipe, and an air flow containing the mixed powder is formed in the first pipe and the second pipe;

[0013] Step 2: In the first pipeline, negative ions are generated by ionization through the positive discharge needle, and the negative ions are attached to the mixed powder A to form a negatively charged mixed powder A, and then the negatively charged mixed powder A is accelerated by the compressed gas supply device and transported to the mixing device;

[0014] Step 3: In the second pipeline, positive ions are generated by ionization through the negative discharge needle, and the positive ions are attached to the mixed powder B to form a positively charged mixed powder B. The positively charged mixed powder B is then accelerated by the compressed gas supply device and transported to the mixing device;

[0015] Step 4: Mixing the mixed powder A and the mixed powder B in a mixing device can construct core-shell coated composite particles, wherein the mixed powder B serves as shell particles and the mixed powder A serves as core particles.

[0016] Furthermore, in the pulverizing step, the pulverizing time of the mixed powder A is 48 min to 60 min, and the pulverizing time of the mixed powder B is 2 min to 4 min. The particle size of the finally obtained mixed powder B is 5 to 10 times that of the mixed powder A.

[0017] Furthermore, the ultrafine grinding mentioned in the grinding step adopts vibration ultrafine grinding, with a vibration frequency of 1000r / min to 1500r / min, an amplitude of 3mm to 15mm, and a grinding temperature of -10°C.

[0018] Furthermore, in the sterilization step, the mixed powder B is sterilized by ethanol sterilization, using 75% ethanol for 2h to 5h under the conditions of a vacuum degree of -0.05MPa to -0.08MPa and a temperature of 60°C to 75°C.

[0019] Furthermore, the first pipeline and the second pipeline in the compounding step are respectively connected to two compressed gas supply devices.

[0020] Furthermore, the compounding step also includes a high-voltage power supply device, and the positive discharge needle and the negative discharge needle are respectively connected to the high-voltage power supply device.

[0021] Furthermore, a formula of a ten-flavor hand ginseng powder is made from the following raw materials in parts by weight: 2-15 parts of hand ginseng, 2-15 parts of cinnamon bark, 20-150 parts of cardamom, 10-60 parts of piperine, 10-60 parts of asparagus, 10-60 parts of pomegranate seeds, 10-60 parts of sword bean, 10-60 parts of safflower, 1-6 parts of artificial musk, and 1-6 parts of bear bile.

[0022] Compared with the prior art, the present invention has the following advantages and significant progress:

[0023] (1) The present invention adopts core-shell nanoparticle technology, and uses precious fine medicinal materials with volatile active ingredients or small components as core particles, which are encapsulated in shell particles to increase the retention rate of the active ingredients.

[0024] (2) According to the different textures of Chinese medicine, the fineness of Chinese medicine powder is purposefully classified and made positively or negatively charged. The shell particles are selectively attached to the core particles through van der Waals forces and electrostatic effects, achieving orderly mixing of different powders and improving the preparation rate of core-shell coated composite particles.

[0025] (3) The low-temperature ethanol sterilization method was used to sterilize safflower, bear bile, and artificial musk, which shortened the sterilization cycle, reduced the sterilization cost, and retained the volatile active ingredients to the greatest extent. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 : Flow chart of the preparation method of ten-flavor hand ginseng powder of the present invention.

[0027] Figure 2 : Schematic diagram of the equipment structure in the compounding step. The symbols in the figure indicate: 1-first pipeline, 2-second pipeline, 3-mixing device, 4-positive discharge needle, 5-negative discharge needle, 6-high voltage power supply device. DETAILED DESCRIPTION

[0028] The following will further describe in detail other inventive objects, technical solutions and beneficial effects of the present invention in conjunction with the embodiments, but the embodiments should not be regarded as limiting the rights of the present invention. It should be noted that the following detailed descriptions are exemplary and are intended to provide further explanation of the present invention. Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as those commonly understood by ordinary persons in the field of the present invention.

[0029] Study on the preparation process of Shiwei Shoushen Powder

[0030] Take the shell particles of Piper longum, Asparagus cochinchinensis, Pomegranate seeds, Sword bean, and Safflower, put them in a vibration mill, mix and grind them to obtain mixed powder A, take samples regularly, and detect the powder particle size according to the law. Take the core particles of cinnamon, cardamom, ginseng, artificial musk, and bear gall, put them in a vibration mill, mix and grind them to obtain mixed powder B, take samples regularly, and detect the powder particle size according to the law.

[0031] Table 1 Particle size test results of mixed powder A (μm)

[0032]

[0033]

[0034] Table 2 Particle size test results of mixed powder B (μm)

[0035]

[0036] Table 3 Crushing time-particle size (d0.9) regression equation

[0037]

[0038] Note: After regression analysis of variance: ***p<0.001

[0039] There is a good correlation between the crushing time and the particle size of the material. The minimum particle size of mixed powder A is 27.33μm at 48.97min; the minimum particle size of mixed powder B is 52.32μm at 22.28min.

[0040] In order to ensure that the particle size of mixed powder B is 5 to 10 times that of mixed powder A, mixed powder A should be crushed for 48 to 60 minutes, and mixed powder B should be crushed for 2 to 4 minutes.

[0041] Example 1

[0042] The ten-flavor hand ginseng powder is composed of the following materials: 2 parts of hand ginseng, 2 parts of cinnamon bark, 20 parts of cardamom, 10 parts of piperine, 10 parts of asparagus, 10 parts of pomegranate seeds, 10 parts of sword bean, 10 parts of safflower, 1 part of artificial musk, and 1 part of bear bile.

[0043] Weighing: weigh the raw materials of ginseng, cinnamon bark, cardamom, longan, asparagus, pomegranate seeds, sword bean, safflower, artificial musk, and bear bile;

[0044] Drying: Piper longum, asparagus cochinchinensis, pomegranate seeds, sword beans, safflower, cinnamon bark, cardamom, and ginseng are dried;

[0045] Crushing: put five medicinal materials such as Piper longum, Asparagus cochinchinensis, Pomegranate seeds, Sword bean, and Safflower into a grinder at -10°C, a vibration frequency of 1250 r / min, and an amplitude of 8 mm, mix and ultrafine grind for 50 minutes to obtain mixed powder A; under the same conditions, mix and ultrafine grind five medicinal materials such as cinnamon bark, cardamom, ginseng, bear gall, and artificial musk for 3 minutes to obtain mixed powder B;

[0046] (5) Sterilization: Sterilize the mixed powder A at 105°C for 2 h, and then dry it to a moisture content of ≤7%. Sterilize the mixed powder B with 75% ethanol at a vacuum of -0.07 MPa and a temperature of 65°C for 2 h, and then dry it to a moisture content of ≤7%.

[0047] (6) Compounding: Step 1: Place the mixed powder A in the first pipe 1, and the mixed powder B in the second pipe 2, and form an air flow with the mixed powder in the first pipe 1 and the second pipe 2;

[0048] Step 2: In the first pipeline 1, the positive discharge needle 4 ionizes to generate negative ions, and the negative ions attach to the mixed powder A to form a negatively charged mixed powder A, and then the negatively charged mixed powder A is accelerated by the compressed gas supply device and transported to the mixing device;

[0049] Step 3: In the second pipe 2, the negatively charged discharge needle 5 ionizes to generate positive ions, which are attached to the mixed powder B to form a positively charged mixed powder B. The positively charged mixed powder B is then accelerated by the compressed gas supply device and transported to the mixing device 3;

[0050] Step 4: Mix the mixed powder A and the mixed powder B in a mixing device for about 4 minutes to construct core-shell coated composite particles, in which the five medicinal materials such as Piper longum, Asparagus cochinchinensis, Pomegranate seeds, Sword bean, and Safflower are used as shell particles, and the five medicinal materials such as Ginseng palm, Bear gall, artificial musk, cinnamon, and cardamom are used as core particles.

[0051] Comparative Example 1

[0052] This comparative implementation example 1 adopts the traditional powder preparation method to prepare Shiwei Shoushen powder.

[0053] The ten-flavor hand ginseng powder is composed of the following materials: 2 parts of hand ginseng, 2 parts of cinnamon bark, 20 parts of cardamom, 10 parts of piperine, 10 parts of asparagus, 10 parts of pomegranate seeds, 10 parts of sword bean, 10 parts of safflower, 1 part of artificial musk, and 1 part of bear bile.

[0054] Weigh the prescribed amount of ginseng, cinnamon bark, cardamom, piper longum, asparagus cochinchinensis, pomegranate seeds, sword bean, and safflower and grind them;

[0055] The mixed powder was sterilized at a sterilization temperature of 105°C for 2 hours, and then dried in a hot air circulation oven until the moisture content was acceptable;

[0056] Crush the bear bile and artificial musk with a small grinder, and mix them with sterilization powder for 60 minutes.

[0057] Comparative Example 2

[0058] The ten-flavor hand ginseng powder is composed of the following materials: 2 parts of hand ginseng, 2 parts of cinnamon bark, 20 parts of cardamom, 10 parts of piperine, 10 parts of asparagus, 10 parts of pomegranate seeds, 10 parts of sword bean, 10 parts of safflower, 1 part of artificial musk, and 1 part of bear bile.

[0059] Weighing: weigh the raw materials of ginseng, cinnamon bark, cardamom, longan, asparagus, pomegranate seeds, sword bean, safflower, artificial musk, and bear bile;

[0060] Drying: Piper longum, asparagus cochinchinensis, pomegranate seeds, sword beans, safflower, cinnamon bark, cardamom, and ginseng are dried;

[0061] Crushing: put five medicinal materials such as Piper longum, Asparagus cochinchinensis, Pomegranate seeds, Sword bean, and Safflower into a grinder at -10°C, a vibration frequency of 1250 r / min, and an amplitude of 8 mm, mix and ultrafine grind for 50 minutes to obtain mixed powder A; under the same conditions, mix and ultrafine grind five medicinal materials such as cinnamon bark, cardamom, ginseng, bear gall, and artificial musk for 3 minutes to obtain mixed powder B;

[0062] (5) Sterilization: Sterilize the mixed powder A at 105°C for 2 h, and then dry it to a moisture content of ≤7%. Sterilize the mixed powder B with 75% ethanol at a vacuum of -0.07 MPa and a temperature of 65°C for 2 h, and then dry it to a moisture content of ≤7%.

[0063] (6) Mixing: Mix sterilized powder A and sterilized powder B for 4 minutes.

[0064] Artificial musk is one of the precious and fine medicinal materials in the prescription, which has a direct impact on the quality of the medicine. At the same time, musk ketone is a volatile component. If the retention rate is high, it can be proved that the core particles are wrapped in the shell particles. Therefore, the retention rate of musk ketone is measured for the examples and comparative examples.

[0065] Detection method: Determined according to the gas chromatography method (General Chapter 0521) of the 2020 edition of the Chinese Pharmacopoeia.

[0066] Table 4 Comparison of musk ketone retention rates at different temperatures between the examples and the comparative examples

[0067]

[0068] The results show that the musk ketone retention rate of Example 1 is better than that of Comparative Example 2, and the musk ketone retention rate of Comparative Example 2 is better than that of Comparative Example 1, indicating that the artificial musk in Comparative Example 1 is encapsulated in the shell particles as core particles, Comparative Example 2 may form partial core-shell composite particles, and Comparative Example 1 is a mixed powder with a disordered structure.

[0069] That is, the ten-flavor hand-ginseng powder prepared by adopting the technical solution of the present invention can achieve the beneficial effect of improving the retention rate of effective ingredients.

[0070] To further confirm the existence of the core-shell structure, the color difference of the examples and comparative examples was checked.

[0071] The color was evaluated using the CIE1976 L*a*b* color space. The color of the shell particle sample was used as the standard value. The color difference between the sample color and the shell particle color was detected to determine whether a core-shell structure existed.

[0072] Table 5 Color difference inspection results

[0073]

[0074] Taking the color of the shell particle sample as the standard value, the color difference between the sample of Example 1 and the shell particle sample is only 0.32. According to the CIE1976L*a*b* color space, dE*<2 means that the color difference is very small, indicating that the colors are basically the same, indicating that the surface color of the sample of Example 1 and the surface color of the shell particle sample show consistent color characteristics and belong to the same material. The color difference between the sample of Comparative Example 1 and the shell particle sample is as high as 13.22. According to the CIE1976L*a*b* color space, dE*>4 means that the color difference is very large, indicating that the surface color of the sample of Comparative Example 1 is inconsistent with the surface color of the shell particle sample and does not belong to the same material. The color difference between the sample of Comparative Example 2 and the shell particle sample is 3.99, and 2≤dE*≤4 means that the color difference value is large, indicating that the surface color of the sample of Comparative Example 2 is quite different from the surface color of the shell particle sample, and the same species may exist. The above results indicate that Example 1 contains composite particles with a core-shell structure, Comparative Example 1 does not contain composite particles with a core-shell structure, and Comparative Example 2 may contain composite particles with a partial core-shell structure.

[0075] The above results indicate that the Shiwei Shoushen powder prepared by the technical solution of the present application is composed of shell particles coated on the surface of shell particles to form a core-shell structure.

Claims

1. A preparation process of ten-flavor hand ginseng powder, characterized in that: The steps include: Weighing: weigh the raw materials of ginseng, cinnamon bark, cardamom, longan, asparagus, pomegranate seeds, sword bean, safflower, artificial musk, and bear bile; Drying: Piper longum, asparagus cochinchinensis, pomegranate seeds, sword beans, safflower, cinnamon bark, cardamom, and ginseng are dried; Grinding: Mix and ultrafine grind five medicinal materials including Piper longum, Asparagus cochinchinensis, Pomegranate seeds, Sword bean and Carthamus tinctorius to obtain mixed powder A; Mix and ultrafine grind five medicinal materials including Cinnamon bark, Cardamom, Ginseng palm, Artificial Musk and Bear Gall to obtain mixed powder B; Sterilization: sterilize mixed powder A and mixed powder B respectively, and then dry them respectively until the moisture content is ≤7%; Compounding: Step 1: Place mixed powder A in a first pipe, and mixed powder B in a second pipe, and form an air flow with mixed powder in the first pipe and the second pipe; Step 2: In the first pipeline, negative ions are generated by ionization through the positive discharge needle, and the negative ions are attached to the mixed powder A to form a negatively charged mixed powder A, and then the negatively charged mixed powder A is accelerated by the compressed gas supply device and transported to the mixing device; Step 3: In the second pipeline, positive ions are generated by ionization through the negative discharge needle, and the positive ions are attached to the mixed powder B to form a positively charged mixed powder B. The positively charged mixed powder B is then accelerated by the compressed gas supply device and transported to the mixing device; Step 4: Mixing the mixed powder A and the mixed powder B in a mixing device to construct core-shell coated composite particles, wherein the mixed powder B serves as shell particles and the mixed powder A serves as core particles; In the preparation process, the pulverizing time of the mixed powder A in the pulverizing step is 48 minutes to 60 minutes, and the pulverizing time of the mixed powder B is 2 minutes to 4 minutes, and the particle size of the finally obtained mixed powder B is 5 to 10 times that of the mixed powder A; In the preparation process, the ultrafine grinding mentioned in the grinding step adopts vibration ultrafine grinding, the vibration frequency is 1000r / min~1500r / min, the amplitude is 3mm~15mm, and the grinding temperature is -10℃; In the preparation process, the sterilization method of the mixed powder B in the sterilization step is ethanol sterilization, and 75% ethanol is used for 2h to 5h of sterilization under the conditions of vacuum degree of -0.05MPa to -0.08MPa and temperature of 60℃ to 75℃; In the preparation process, the first pipeline and the second pipeline in the compounding step are respectively connected to two compressed gas supply devices; The preparation process, in the compounding step, also includes a high-voltage power supply device, and the positive discharge needle and the negative discharge needle are respectively connected to the high-voltage power supply device.

2. The preparation process of the ten-flavor hand ginseng powder according to claim 1, characterized in that: The ten-flavor hand ginseng powder is prepared from the following raw materials in parts by weight: 2-15 parts of hand ginseng, 2-15 parts of cinnamon bark, 20-150 parts of cardamom, 10-60 parts of piperine, 10-60 parts of asparagus, 10-60 parts of pomegranate seeds, 10-60 parts of sword bean, 10-60 parts of safflower, 1-6 parts of artificial musk and 1-6 parts of bear bile.

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