Repair cream containing ergothioneine and preparation method thereof

Abstract

The invention discloses a repair cream containing ergothioneine and a preparation method thereof. The repair cream containing ergothioneine comprises a phase A: caprylic / capric triglyceride, cetearyl alcohol, an emulsifier, an emollient, and a whitening agent a; a phase B: water, butylene glycol, glycerol, glycerol polyether-26, propylene glycol, hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, p-hydroxyacetophenone, and a moisturizer; a phase C: niacinamide; a phase D: beta-glucan, capryloylhydroxamic acid, a whitening agent b, and a skin conditioner; wherein the skin conditioner comprises soybean polypeptide, kaempferia galanga root extract, ergothioneine, palmitoyl pentapeptide-4, and biosaccharide gum-1; a preparation method of the repair cream containing ergothioneine comprises mixing the components; the application has the effect of promoting skin absorption, and realizes the skin care effect of moisturizing, whitening, and anti-aging multi-effect integration, and perfectly embodies the "streamlined skin care" concept of skin care in terms of precision rather than quantity.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, in particular to a repair cream containing ergothioneine and a preparation method thereof. Background Art

[0002] Nowadays, with the promotion effect of various short videos and soft articles, the skin care process of "cleansing-water-lotion-essence-eye cream-face cream-sunscreen" has long been deeply rooted in people's minds. This has also caused consumers to fall into a misunderstanding about skin care. They always think that the more skin care products I apply on my face, the better the skin care effect will be. Especially as I get older, my skin condition becomes worse and worse. In order to improve my skin, consumers spare no effort to apply all kinds of skin care products on their faces, but this approach often yields little results, especially after the skin age is 40+, even if a thick layer of skin care products is applied on the face, the skin still feels "dry".

[0003] As we all know, with the increase of age, the absorption capacity of the skin is bound to become worse and worse. This is an irreversible natural aging process of the skin. With the increase of age, it is bound to be more and more difficult to improve the absorption capacity of the skin. No matter how many skin care products are applied on the face, if they cannot be truly absorbed by the skin, it will not make our skin better and better. On the contrary, this will not only make skin care a cumbersome thing, but also increase the burden on the skin to a certain extent. Especially for consumers with skin age of 40+, they should pursue easily absorbed skin care products instead of applying more skin care products on their faces. At present, most of the skin care products on the market for skin age of 40+ focus on anti-aging. Not only are the effects single, but even if many effective anti-aging ingredients are added to such products, the actual anti-aging effect is often unsatisfactory. You know, even if the skin care ingredients are the same, due to the poor absorption capacity of skin age of 40+, its skin care effect is always not as good as that of young skin age. Therefore, it is very necessary to develop a multi-functional and easily absorbed skin care product for skin age of 40+ to maximize the absorption capacity of skin care ingredients for elderly skin age and achieve better skin care effects. Summary of the invention

[0004] In order to solve the problem of poor absorption capacity of 40+ skin age, the present application provides a repair cream containing ergothioneine and a preparation method thereof. The present application is a combination formed by a unique formula, especially by synergistic action of soybean polypeptide, kaempferia root extract, ergothioneine, palmitoyl pentapeptide-4, and biosaccharide gum-1 through different mechanisms of action on the skin, to achieve the effect of enhancing the absorption capacity of the skin, even if the skin of 40+ skin age is after using the repair cream containing ergothioneine prepared by the present application, it can still have a good absorption effect, and realizes the skin care effect of moisturizing, whitening, and anti-aging multi-effect integration, which perfectly embodies the "streamlined skin care" concept of skin care in fine rather than in large quantities.

[0005] In the first aspect, the present application provides a repair cream containing ergothioneine using the following technical solution:

[0006] A repairing cream containing ergothioneine, comprising the following components in percentage by mass:

[0007] Phase A:

[0008] Caprylic / capric triglyceride: 2% to 5%;

[0009] Cetearyl alcohol: 1% to 2%;

[0010] Emulsifier: 1.1%~3%;

[0011] Emollients: 9% to 16%;

[0012] Whitening agent a: 0.1% to 0.5%;

[0013] Phase B:

[0014] Water: 55%-60%;

[0015] Butanediol: 3% to 5%;

[0016] Propylene glycol: 1% to 2%;

[0017] Glycerol: 3% to 5%;

[0018] Glyceryl polyether-26: 1% to 2%;

[0019] Hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer: 0.1% to 0.5%;

[0020] p-Hydroxyacetophenone: 0.1% to 0.3%;

[0021] Moisturizer: 0.31% to 2.53%;

[0022] Phase C:

[0023] Niacinamide: 2% to 3%

[0024] Phase D:

[0025] β-Glucan: 1% to 2%;

[0026] Octanoylhydroxamic acid: 0.2% to 0.4%;

[0027] Whitening agent b: 1.01% to 2.1%;

[0028] Skin conditioners: 2.61% to 5.52%;

[0029] The skin conditioner is calculated based on the mass percentage of the repair cream containing ergothioneine, including 1% to 2% soybean polypeptide, 0.1% to 1% kaempferia galanga root extract, 0.01% to 0.02% ergothioneine, 0.1% to 0.5% palmitoyl pentapeptide-4, and 1% to 2% biosaccharide gum-1.

[0030] In the above technical scheme, soybean peptides have the ability to directly penetrate into the cortex to replenish lost collagen, which gives it the effect of restoring skin elasticity, promoting cell metabolism, and delaying cell aging; Kaempferia galanga root extract has antibacterial effect and has inhibitory effects on a variety of human enzymes, especially tyrosinase, so Kaempferia galanga root extract has good whitening effect; ergothioneine has good free radical scavenging effect and ultraviolet ray filtering effect, and can also play a cell protection role in the human body. It is a hot skin care ingredient in recent years, which can effectively whiten, reduce inflammation, remove acne, and resist aging; palmitoyl pentapeptide-4 is a small molecule peptide with high specificity and biological activity, which can promote the synthesis of fibrin and reduce the formation of wrinkles; biosaccharide gum-1 contains high molecular weight polysaccharides, which can stably adhere to the skin and resist external stimuli.

[0031] Soy peptides, ergothioneine, and palmitoyl pentapeptide-4 work synergistically with each other to improve the vitality of epidermal cells, temporarily stimulate the strong absorption capacity of epidermal cells, and promote the penetration and absorption of effective ingredients in the repair cream containing ergothioneine by epidermal cells. Assisted by the synergistic effect of biosaccharide gum-1 and kaempferia galanga root extract on the surface of the skin, more effective ingredients in the repair cream containing ergothioneine are further promoted to either stably fit with the epidermal cells and gradually exert their effects, or be directly absorbed by the skin along with soybean peptides, kaempferia galanga root extract, ergothioneine, and palmitoyl pentapeptide-4, truly acting on the skin endogenously, overcoming the problem of poor absorption capacity of 40+ skin age, making skin care more effective.

[0032] In this application, soybean peptides, ergothioneine, palmitoyl pentapeptide-4, biosaccharide gum-1 and kaempferia galanga root extract can significantly promote the action of the active ingredients in the repair cream containing ergothioneine on the skin, and are supplemented by the skin care effects of whitening agents, moisturizers, emollients, etc. added to the formula, thereby achieving a skin care effect of moisturizing, whitening and anti-aging.

[0033] Preferably, the emollient comprises isopropyl myristate, vaccinium macrocarpon seed oil, garcinia indica seed butter, and dimethicone.

[0034] In the above technical scheme, the emollient compounded with isopropyl myristate, blueberry seed oil, Indian garcinia seed fat and polydimethylsiloxane can promote the repair cream containing ergothioneine to establish a more skin-friendly oily system, further improve the permeability of epidermal cells, and promote the skin to absorb the effective substances in the repair cream containing ergothioneine. Assisted by the original emollient effect of the emollient, further interact with biosaccharide gum-1 and Kaempferia galanga root extract, a protective film is evenly attached to the surface of the skin, and more macromolecular effective ingredients in the repair cream containing ergothioneine are promoted to be stably attached to the epidermal cells and gradually exert their effects, achieving the effect of lasting nourishment of the skin.

[0035] Preferably, the emollient, measured by mass percentage of the repair cream containing ergothioneine, includes 3% to 5% isopropyl myristate, 3% to 5% blueberry seed oil, 2% to 4% Indian garcinia seed fat, and 1% to 2% dimethicone.

[0036] In the above technical solution, the emollient prepared according to the above formula has a better emollient effect and can further enhance the skin affinity of the repair cream containing ergothioneine.

[0037] Preferably, the moisturizing agent includes panthenol, hydrogenated starch hydrolyzate, hydrolyzed red algae extract, and 5000-8000 Dalton sodium hyaluronate.

[0038] In the above technical scheme, the repair cream containing ergothioneine, which is compounded by panthenol, hydrogenated starch hydrolysate, hydrolyzed red algae extract, and 5000-8000 Dalton sodium hyaluronate, has a good long-lasting moisturizing effect, can replenish skin moisture from the endogenous source, inhibit the evaporation of skin moisture from the outside, and keep the skin in a saturated moisture state. It is supplemented by the synergistic absorption-promoting effect of soybean peptides, ergothioneine, palmitoyl pentapeptide-4, biosaccharide gum-1 and kaempferia galanga root extract, and can achieve significant long-lasting moisturizing effect.

[0039] Preferably, the moisturizing agent, measured by mass percentage of the repair cream containing ergothioneine, includes 0.1% to 0.5% panthenol, 0.1% to 1% hydrogenated starch hydrolysate, 0.1% to 1% hydrolyzed red algae extract, and 0.01% to 0.03% 5000 to 8000 Dalton sodium hyaluronate.

[0040] In the above technical solution, the moisturizer prepared according to the above special ratio can better synergistically exert the moisturizing effect, promote the sodium hyaluronate therein to be absorbed by the skin, and achieve the effect of long-term water locking.

[0041] Preferably, the whitening agent b includes pomegranate sterols and arginine ferulate.

[0042] In the above technical scheme, pomegranate sterols and arginine ferulate work synergistically with each other, which can significantly inhibit the activity of tyrosinase and the activity of melanocytes in the skin, and are assisted by the synergistic absorption-promoting effect of soybean peptides, ergothioneine, palmitoyl pentapeptide-4, biosaccharide gum-1 and kaempferia galanga root extract, thereby achieving a significant effect of removing dull skin.

[0043] Preferably, the whitening agent b, measured by the mass percentage of the repair cream containing ergothioneine, comprises 1% to 2% of pomegranate sterols and 0.01% to 0.1% of arginine ferulate.

[0044] The whitening agent B prepared by the proportioning of the above technical solution, wherein the pomegranate sterols and arginine ferulate can work better synergistically to achieve a better effect of removing dull skin.

[0045] Preferably, the whitening agent a is bitter orange flower oil, and the mass percentage of the bitter orange flower oil in the repair cream containing ergothioneine is 0.1% to 0.5%.

[0046] In the above technical scheme, choosing bitter orange flower oil as whitening agent a can cooperate with whitening agent b to significantly lighten skin color, and at the same time can be further compounded with soybean peptide, ergothioneine, and palmitoyl pentapeptide-4 to further open skin channels, stimulate the skin's absorption of effective ingredients, and effectively inhibit the unpleasant odor of ergothioneine, so that consumers have a better skin care experience.

[0047] Preferably, the emulsifier includes sucrose polystearate and trideceth-10.

[0048] In the above technical scheme, the emulsifier formed by compounding sucrose polystearate and trideceth-10 is selected, so that the prepared repair cream containing ergothioneine can have a more stable emulsified system.

[0049] In a second aspect, the present application provides a method for preparing a repair cream containing ergothioneine using the following technical scheme:

[0050] A method for preparing a repair cream containing ergothioneine comprises the following steps:

[0051] (1) Dissolve and mix the raw materials of phase A at 75-80°C; dissolve and disperse the raw materials of phase B at 82-85°C;

[0052] (2) mixing phase A and phase B at 82-85° C., homogenizing and emulsifying for 5-8 minutes, and keeping warm for 10-15 minutes to obtain a first mixture;

[0053] (3) cooling the first mixture to 60-65° C., adding the raw materials of phase C, and homogenizing for 1-2 minutes to obtain a second mixture;

[0054] (4) The second mixture is cooled to 45-55° C., and the raw materials of phase D are added thereto. After homogenization for 3-5 minutes, a repair cream containing ergothioneine is obtained.

[0055] The repair cream containing ergothioneine prepared by adopting the above technical scheme has stable components, is easy to absorb, and has excellent comprehensive skin care effects; and the preparation method of the present application is simple and has industrial production value.

[0056] In summary, the present application includes at least one of the following beneficial technical effects:

[0057] 1. The present application adopts the synergistic effect of soybean peptides, ergothioneine, and palmitoyl pentapeptide-4, which can improve the vitality of epidermal cells, temporarily stimulate the strong absorption capacity of epidermal cells, and promote the penetration and absorption of effective ingredients in the repair cream containing ergothioneine by epidermal cells, and then supplemented by the synergistic effect of biosaccharide gum-1 and kaempferia root extract on the surface of the skin, further promoting more effective ingredients in the repair cream containing ergothioneine to be stably fitted with epidermal cells and gradually exert their effects, or following soybean peptides, kaempferia root extract, ergothioneine, and palmitoyl pentapeptide-4. It is directly absorbed by the skin, truly acting on the endogenous skin, overcoming the problem of poor absorption capacity of 40+ skin age skin, making skin care more effective.

[0058] 2. The application adopts isopropyl myristate, macroberry seed oil, Indian garcinia seed fat, and polydimethylsiloxane compounded emollients, which can promote the repair cream containing thioneine to establish a more skin-friendly oily system, further improve the permeability of epidermal cells, and promote the absorption of the effective substances in the repair cream containing thioneine by the skin. Auxiliary to the original emollient effect of the emollient, further interact with biosaccharide gum-1 and Kaempferia galanga extract, a protective film is evenly attached to the surface of the skin, and more macromolecular effective ingredients in the repair cream containing thioneine are promoted to be stably fitted with epidermal cells and gradually exert their effects, reaching the effect of lasting nourishment of the skin.

[0059] 3. The repair cream containing ergothioneine, which is compounded by panthenol, hydrogenated starch hydrolysate, hydrolyzed red algae extract, and 5000-8000 Dalton sodium hyaluronate, has a good long-lasting moisturizing effect, can replenish skin moisture from the endogenous source, inhibit the evaporation of skin moisture from the outside, and keep the skin saturated with moisture. It is supplemented by the synergistic absorption-promoting effect of soybean peptides, ergothioneine, palmitoyl pentapeptide-4, biosaccharide gum-1 and kaempferia galanga root extract, and can achieve significant long-lasting moisturizing effect.

[0060] 4. The present application selects neroli oil as whitening agent a, pomegranate sterols and arginine ferulate as whitening agent b, which can significantly inhibit the activity of tyrosinase and the activity of melanocytes in the skin, and is supplemented by the synergistic absorption-promoting effect of soybean peptides, ergothioneine, palmitoyl pentapeptide-4, biosaccharide gum-1 and kaempferia galanga root extract, thereby achieving a significant effect of removing skin dullness and lightening skin color.

[0061] 5. In this application, soybean polypeptide, ergothioneine, palmitoyl pentapeptide-4, biosaccharide gum-1 and kaempferia galanga root extract can significantly promote the action of the active ingredients in the repair cream containing ergothioneine on the skin. The skin care effects of the whitening agents, moisturizers, emollients and other components specially added in this application significantly enhance the moisturizing, whitening and anti-aging multiple skin care effects of the repair cream containing ergothioneine in this application, truly realizing "streamlined skin care" and being more suitable for consumers with skin age of 40+. DETAILED DESCRIPTION

[0062] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0063] The raw materials used in the following specific examples are all commercially available and comply with the requirements of the "Technical Specifications for Safety of Cosmetics".

[0064] Example 1

[0065] A repair cream containing ergothioneine comprises phase A: 5kg of caprylic / capric triglyceride, 1kg of cetearyl alcohol, 1.1kg of emulsifier, 12.5kg of moisturizer, and 0.3kg of whitening agent a; phase B: 56.88kg of water, 5kg of butylene glycol, 4kg of glycerol, 1kg of glyceryl polyether-26, 2kg of propylene glycol, 0.2kg of hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, 0.3kg of p-hydroxyacetophenone, and 0.31kg of moisturizer; phase C: 3kg of niacinamide; phase D: 1kg of beta-glucan, 0.3kg of capryloylhydroxamic acid, 2.1kg of whitening agent b, and 4.01kg of skin conditioner.

[0066] The emulsifier is a compound of 1 kg sucrose polystearate and 0.1 kg tridecyl alcohol polyether-10.

[0067] Among them, the skin conditioner is a combination of 1.5kg soybean peptide, 0.7kg kaempferia root extract, 0.01kg ergothioneine, 0.3kg palmitoyl pentapeptide-4, and 1.5kg biosaccharide gum-1.

[0068] Among them, the moisturizer is a combination of 0.3kg panthenol and 0.1kg small molecule sodium hyaluronate.

[0069] Among them, the emollient is a combination of 10.8 kg of isopropyl myristate and 1.7 kg of polydimethylsiloxane.

[0070] Among them, whitening agent a is rose oil.

[0071] Among them, whitening agent b is pomegranate sterols.

[0072] Among them, the Kaempferia galanga root extract was extracted by alcohol extraction and purchased from Lanzhou Waterless Biological Co., Ltd.

[0073] Wherein, the preparation method of the repair cream containing ergothioneine comprises the following steps:

[0074] (1) Dissolve and mix all the raw materials of phase A at 75°C; dissolve and disperse all the raw materials of phase B at 82°C;

[0075] (2) mixing phase A and phase B at 82° C., homogenizing and emulsifying for 8 minutes, and then keeping warm for 15 minutes to obtain a first mixture;

[0076] (3) Cooling the first mixture to 60° C., adding the raw materials of phase C, and homogenizing for 2 min to obtain a second mixture;

[0077] (4) The second mixture is cooled to 45° C., and the raw materials of phase D are added. After homogenization for 3 minutes, a repair cream containing ergothioneine is obtained.

[0078] Example 2

[0079] A repair cream containing ergothioneine, which is different from Example 1 in that it comprises phase A: 3kg of caprylic / capric triglyceride, 1.5kg of cetearyl alcohol, 2.3kg of emulsifier, 16kg of emollient, and 0.1kg of whitening agent a; phase B: 57.02kg of water, 3kg of butylene glycol, 3kg of glycerol, 2kg of glyceryl polyether-26, 1.5kg of propylene glycol, 0.5kg of hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, 0.1kg of p-hydroxyacetophenone, and 1.62kg of moisturizer; phase C: 2kg of niacinamide; phase D: 2kg of beta-glucan, 0.2kg of caprylhydroxamic acid, 1.55kg of whitening agent b, and 2.61kg of skin conditioner.

[0080] The emulsifier is a compound of 1.6 kg sucrose polystearate and 0.7 kg tridecyl alcohol polyether-10.

[0081] Among them, the skin conditioner is a combination of 1kg soybean peptide, 0.5kg kaempferia root extract, 0.01kg ergothioneine, 0.1kg palmitoyl pentapeptide-4, and 1kg biosaccharide gum-1.

[0082] Among them, the moisturizer is a combination of 1.6kg panthenol and 0.02kg small molecule sodium hyaluronate.

[0083] Among them, the emollient is a combination of 14kg isopropyl myristate and 2kg polydimethylsiloxane.

[0084] Wherein, the preparation method of the repair cream containing ergothioneine comprises the following steps:

[0085] (1) Dissolve and mix the raw materials of phase A at 80°C; dissolve and disperse the raw materials of phase B at 85°C;

[0086] (2) mixing phase A and phase B at 85° C., homogenizing and emulsifying for 5 minutes, and keeping warm for 10 minutes to obtain a first mixture;

[0087] (3) Cooling the first mixture to 65° C., adding the raw materials of phase C, and homogenizing for 1 min to obtain a second mixture;

[0088] (4) The second mixture is cooled to 55° C., and the raw materials of phase D are added. After homogenization for 5 minutes, a repair cream containing ergothioneine is obtained.

[0089] Example 3

[0090] A repair cream containing ergothioneine, which is different from Example 1 in that it comprises phase A: 2kg caprylic / capric triglyceride, 2kg cetearyl alcohol, 3kg emulsifier, 9kg emollient, 0.5kg whitening agent a; phase B: 57.74kg water, 4kg butylene glycol, 5kg glycerol, 1.5kg glyceryl polyether-26, 1kg propylene glycol, 0.1kg hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, 0.2kg p-hydroxyacetophenone, 2.53kg humectant; phase C: 2.5kg niacinamide; phase D: 2kg β-glucan, 0.4kg caprylhydroxamic acid, 1.01kg whitening agent b, 5.52kg skin conditioner.

[0091] The emulsifier is a compound of 2kg sucrose polystearate and 1kg trideceth-10.

[0092] Among them, the skin conditioner is a combination of 2kg soybean peptide, 1kg kaempferia root extract, 0.02kg ergothioneine, 0.5kg palmitoyl pentapeptide-4, and 2kg biosaccharide gum-1.

[0093] Among them, the moisturizer is a combination of 2.5kg panthenol and 0.03kg small molecule sodium hyaluronate.

[0094] Among them, the emollient is a combination of 8kg isopropyl myristate and 1kg dimethicone.

[0095] Example 4

[0096] A repair cream containing ergothioneine, which is different from Example 3 in that the emollient is a combination of 3kg of isopropyl myristate, 3kg of blueberry seed oil, 2kg of Indian garcinia seed fat, and 1kg of polydimethylsiloxane.

[0097] Example 5

[0098] A repair cream containing ergothioneine, which is different from Example 4 in that an equal amount of blueberry seed oil is replaced by jojoba seed oil.

[0099] Example 6

[0100] A repair cream containing ergothioneine, which is different from Example 4 in that an equal amount of Indian garcinia seed butter is replaced by mango seed butter.

[0101] Example 7

[0102] A repair cream containing ergothioneine, which is different from Example 3 in that the moisturizer is a combination of 0.5 kg panthenol, 1 kg hydrogenated starch hydrolysate, 1 kg hydrolyzed red algae extract, and 0.03 kg small molecule sodium hyaluronate.

[0103] Example 8

[0104] A repair cream containing ergothioneine, which is different from Example 3 in that whitening agent a is bitter orange flower oil; whitening agent b is a combination of 2kg of pomegranate sterols and 0.1kg of arginine ferulate.

[0105] Example 9

[0106] A repair cream containing ergothioneine, which is different from Example 8 in that an equal amount of pomegranate sterols is replaced by tocopherol acetate.

[0107] Example 10

[0108] A repair cream containing ergothioneine, which is different from Example 3 in that:

[0109] The moisturizer is a combination of 0.5 kg panthenol, 1 kg hydrogenated starch hydrolysate, 1 kg hydrolyzed red algae extract, and 0.03 kg small molecule sodium hyaluronate.

[0110] The emollient is a combination of 3kg isopropyl myristate, 3kg vaccinium macrocarpon seed oil, 2kg garcinia indica seed butter, and 1kg dimethicone.

[0111] Whitening agent a is bitter orange blossom oil.

[0112] Whitening agent b is a combination of 2 kg of pomegranate sterols and 0.1 kg of arginine ferulate.

[0113] Comparative Example 1

[0114] A repair cream containing ergothioneine, which is different from Example 3 in that an equal amount of soybean peptide is replaced by acetyl hexapeptide-8.

[0115] Comparative Example 2

[0116] A repair cream containing ergothioneine, which is different from Example 3 in that an equal amount of Kaempferia galanga root extract is replaced by ginger extract (alcohol extraction method).

[0117] Comparative Example 3

[0118] A repair cream containing ergothioneine, which is different from Example 3 in that an equal amount of palmitoyl pentapeptide-4 is replaced by water.

[0119] Comparative Example 4

[0120] A repair cream containing ergothioneine, which is different from Example 3 in that an equal amount of biosaccharide gum-1 is replaced by water.

[0121] Comparative Example 5

[0122] A repair cream, which is different from Example 3 in that an equal amount of ergothioneine is replaced by water.

[0123] test

[0124] Test sample: the repair cream of the above embodiments and comparative examples.

[0125] Test 1

[0126] Absorption-promoting effect proof test Principle: Estradiol benzoate ointment promotes breast development. Mixing estradiol benzoate ointment and the test sample and applying them continuously on the mammary glands of mice can promote the growth of the mammary glands of mice. The larger the diameter of the areola of the mouse, the better the effect of promoting mammary gland growth is, which proves that the test sample has a better ability to promote absorption.

[0127] Test subjects: 170 Kunming female mice aged 21 days, weighing 12-14 kg, provided by Saibono Biotechnology Co., Ltd., were randomly divided into 17 groups, including 1 negative control group, 1 positive control group, and 15 test groups.

[0128] Test material: estradiol benzoate ointment (Italie).

[0129] Test method: The chest of mice was shaved. Test group: Every day, estradiol benzoate ointment and test sample were mixed in a 1:1 mass ratio, and the test product was evenly applied to the mammary gland of mice using a latex finger cot. The application amount was required to be (2±0.1) mg / cm 2; Negative control group: Apply an equal amount of vaseline every day; Positive control group: Apply an equal amount of estradiol benzoate ointment and vaseline in a 1:1 mass ratio every day. Shave hair continuously during the test to ensure that hair does not affect the uniformity of sample application.

[0130] Test results: After 30 days of continuous application, the diameter of the right lower abdominal areola of the mice was measured with a vernier caliper (with an accuracy of 50 divisions), and the test results were recorded. The average value of the test results was taken. The test results are shown in Table 1.

[0131] Test subjects: 150 volunteers aged 50 to 60 years old, male and female, without skin diseases were selected and divided into 15 groups, with 10 people in each group.

[0132] Volunteers should not apply any cosmetics or medicines on their face and neck 2 to 3 days before the test. During the test, volunteers should not apply any cosmetics or skin care products other than the test samples on their face and neck.

[0133] Test 2

[0134] The moisturizing effect test is carried out according to QB / T4256-2011. The higher the water content, the better the moisturizing effect of the test sample.

[0135] Test method: (1) Measure the skin moisture content (%) of the test subjects before using the test samples, and record it as the blank value; (2) Apply the test samples to the skin on the inner side of the left hand of the corresponding test subjects, and the application amount is 2.0 mg / cm 2 Then the test personnel measured the skin moisture content of the test personnel at 1h, 2h and 4h respectively, recorded as 1h, 2h, 4h, and the test results were averaged, see Table 2.

[0136] Test 3

[0137] Whitening effect proof test

[0138] According to the test of T / SHRH015-2018, the higher the inhibition rate, the better the whitening effect of the test sample.

[0139] Test method: The tyrosinase inhibition rate (%) of the above test samples was detected respectively. The test results are shown in Table 2.

[0140] Test 4

[0141] Effect evaluation test

[0142] The testers applied the test samples for one week, once in the morning and once in the evening. After one week, the testers were asked to rate the skin absorption effect, moisturizing effect, whitening effect, nourishing effect and anti-aging effect (0-100 points). The rating standards are as follows:

[0143] Absorption effect: 80-100 points, good absorption effect; 50-79 points, average absorption effect; 0-49 points, poor absorption effect.

[0144] Moisturizing effect: 80-100 points, long-lasting moisturizing; 50-79 points, average moisturizing effect; 0-49 points, poor moisturizing effect.

[0145] Whitening effect: 80-100 points, the skin is obviously brightened and whitened; 50-79 points, the whitening effect is average; 0-49 points, the whitening effect is poor.

[0146] Nourishing effect: 80-100 points, good skin elasticity; 50-79 points, average skin elasticity; 0-49 points, poor skin elasticity.

[0147] Anti-aging effect: 80-100 points, wrinkles at the corners of the eyes are obviously lightened; 50-79 points, the effect of lightening wrinkles at the corners of the eyes is moderate; 0-49 points, the lightening of wrinkles at the corners of the eyes is not obvious.

[0148] The test results are averaged and are shown in Table 3.

[0149] Table 1:

[0150]

[0151] Table 2:

[0152]

[0153] Table 3:

[0154]

[0155]

[0156] The above test results show that Examples 1-10 have better absorption effect, moisturizing effect, whitening effect, nourishing effect and anti-aging effect than Comparative Examples 1-5.

[0157] It can be seen from the comparison of Example 3 and Comparative Examples 1-5 that the absorption-promoting ability of Example 3 is better than that of Comparative Examples 1-5, and the absorption effect, moisturizing effect, whitening effect, nourishing effect and anti-aging effect of Example 3 are all better than those of Comparative Examples 1-5; thus, it can be obtained that the present application adopts soybean polypeptide, ergothioneine, and palmitoyl pentapeptide-4 to synergize with each other, which can stimulate the strong absorption capacity of epidermal cells, and then supplemented with the synergistic effect of biosaccharide gum-1 and kaempferia root extract on the surface of the skin, further promoting more effective ingredients in the repair cream containing ergothioneine or stably fitting with epidermal cells to gradually exert their effects, or following soybean polypeptide, kaempferia root extract, ergothioneine, and palmitoyl pentapeptide-4 to be directly absorbed by the skin, making skin care more effective; in addition, it can be seen from the data of the positive control group and Comparative Examples 1-5 in Table 1 that only soybean polypeptide, ergothioneine, palmitoyl pentapeptide-4, biosaccharide gum-1 and kaempferia root extract synergize with each other to improve the absorption capacity of the skin to a certain extent.

[0158] It can be seen from the comparison of Example 4 and Example 3 and Example 5-6 that the absorption effect, moisturizing effect, whitening effect, nourishing effect and anti-aging effect of Example 4 are more excellent; It can be obtained from this analysis that the application adopts isopropyl myristate, large fruit blueberry seed oil, Indian garcinia seed fat, and polydimethylsiloxane as the compounded emollient, which can promote the repair cream containing ergothioneine to establish a more skin-friendly oily system, further improve the permeability of epidermal cells, promote the absorption of the active substances in the repair cream containing ergothioneine by the skin, and achieve the effect of lasting nourishing skin.

[0159] A comparison of Example 7 and Example 3 shows that the moisturizing effect of Example 7 is better than that of Example 3; from this analysis, it can be obtained that the repair cream containing ergothioneine, which is compounded by panthenol, hydrogenated starch hydrolysate, hydrolyzed red algae extract, and 5000-8000 Daltons of sodium hyaluronate, has a good long-lasting moisturizing effect, can replenish skin moisture from the endogenous source, inhibit the evaporation of skin moisture from the outer edge, and keep the skin in a state of saturated moisture.

[0160] Comparison between Example 8 and Example 3 and Example 9 shows that the tyrosinase inhibition effect of Example 8 is more excellent. From this analysis, it can be concluded that the present application can significantly inhibit the activity of tyrosinase and the activity of melanocytes in the skin by selecting bitter orange flower oil as whitening agent a, pomegranate sterols and arginine ferulate as whitening agent b, thereby achieving a significant effect of removing skin dullness and lightening skin color.

[0161] Comparison of Example 10 and Example 3 shows that the absorption effect, moisturizing effect, whitening effect, nourishing effect and anti-aging effect of Example 10 are more excellent. From this analysis, it can be obtained that soybean polypeptide, ergothioneine, palmitoyl pentapeptide-4, biosaccharide gum-1 and kaempferia root extract can significantly promote the effective ingredients in the repair cream containing ergothioneine to act on the skin. On the basis of this, the whitening agent, moisturizer, emollient and other components specially added in this application have a skin care effect, which significantly improves the moisturizing, whitening and anti-aging multiple skin care effects of the repair cream containing ergothioneine in this application, and truly realizes "streamlined skin care", which is more suitable for consumers with a skin age of 40+.

[0162] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A repair cream containing ergothioneine, characterized in that, The following components are included in mass percentage: Phase A: Caprylic / capric triglyceride: 2%~5%; Cetearyl alcohol: 1%~2%; Emulsifier: 1.1%~3%; Emollients: 9%~16%; Whitening agent a: 0.1%~0.5%; Phase B: Water: 55%~60%; Butanediol: 3%~5%; Propylene glycol: 1%~2%; Glycerin: 3%~5%; Glycerol polyether-26: 1%~2%; Hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer: 0.1%~0.5%; p-Hydroxyacetophenone: 0.1%~0.3%; Moisturizer: 0.31%~2.53%; Phase C: Niacinamide: 2%~3% Phase D: β-Glucan: 1%~2%; Octanoylhydroxamic acid: 0.2%~0.4%; Whitening agent b: 1.01%~2.1%; Skin conditioners: 2.61%~5.52%; Among them, the skin conditioning agent is calculated as the mass percentage of the repair cream containing ergothioneine, including 1%~2% soybean peptide, 0.1%~1% kaempferia galanga root extract, 0.01%~0.02% ergothioneine, 0.1%~0.5% palmitoyl pentapeptide-4, and 1%~2% biosaccharide gum-1; The whitening agent a is bitter orange flower oil, and the mass percentage of the bitter orange flower oil in the repair cream containing ergothioneine is 0.1% to 0.5%; The whitening agent b, calculated based on the mass percentage of the repair cream containing ergothioneine, includes 1% to 2% of pomegranate sterols and 0.01% to 0.1% of arginine ferulate.

2. A repair cream containing ergothioneine according to claim 1, characterized in that, The emollients include isopropyl myristate, vaccinium macrocarpon seed oil, garcinia indica seed butter, and dimethicone.

3. A repair cream containing ergothioneine according to claim 2, characterized in that, The emollient, calculated based on the mass percentage of the repair cream containing ergothioneine, includes 3% to 5% isopropyl myristate, 3% to 5% blueberry seed oil, 2% to 4% Indian garcinia seed fat, and 1% to 2% polydimethylsiloxane.

4. A repair cream containing ergothioneine according to claim 1, characterized in that, The moisturizing agent includes panthenol, hydrogenated starch hydrolyzate, hydrolyzed red algae extract, and 5000-8000 Dalton sodium hyaluronate.

5. A repair cream containing ergothioneine according to claim 4, characterized in that, The moisturizing agent, calculated based on the mass percentage of the repair cream containing ergothioneine, includes 0.1% to 0.5% panthenol, 0.1% to 1% hydrogenated starch hydrolyzate, 0.1% to 1% hydrolyzed red algae extract, and 0.01% to 0.03% 5000 to 8000 Dalton sodium hyaluronate.

6. A repair cream containing ergothioneine according to claim 1, characterized in that, The emulsifiers include sucrose polystearate and trideceth-10.

7. A method for preparing a repair cream containing ergothioneine as described in any one of claims 1 to 6, characterized in that, The steps include: Dissolve and mix all the raw materials of phase A at 75-80°C; dissolve and disperse all the raw materials of phase B at 82-85°C; Mix phase A and phase B at 82-85°C, homogenize and emulsify for 5-8 minutes, and keep warm for 10-15 minutes to obtain a first mixture; The first mixture was cooled to 60-65°C, and the raw materials of phase C were added and homogenized for 1-2 minutes to obtain a second mixture; The second mixture is cooled to 45-55° C., and the raw materials of phase D are added thereto. After homogenization for 3-5 minutes, a repair cream containing ergothioneine is obtained.

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