Purification structure of high performance chromatographic separation device

Abstract

The application discloses a purification structure of a high-efficiency chromatographic separation device, which comprises a supporting seat and a chromatographic column pipe, the chromatographic column pipe is arranged outside the supporting seat, products are separated and purified, the outer side of the chromatographic column pipe is provided with a clamping module, the clamping module provides support for the chromatographic column pipe, the outer side of the clamping module is provided with a connecting rod, and the outer end of the connecting rod is arranged inside the supporting seat, so that the clamping module is provided with support. The purification structure of the high-efficiency chromatographic separation device provides vertical positioning effect for the connecting rod and the clamping module through the movable ball and the counterweight, so that the subsequent chromatographic column pipe can keep vertical and is not affected by the external environment; when the chromatographic column pipe is shaken by the external environment or the supporting surface is inclined and changed, the chromatographic column pipe can also keep the stability of the vertical state, the subsequent purification is facilitated, the purification precision is improved, and the auxiliary limiting mechanism is further arranged on the counterweight, the counterweight is limited, the chromatographic column pipe keeps stable, and shaking and knocking of the subsequent moving equipment are avoided.

Description

Technical Field

[0001] This invention relates to the field of chromatographic separation and purification technology, specifically to a purification structure of a high-efficiency chromatographic separation device. Background Technology

[0002] Chromatographic separation is a common purification method that can separate mixtures that are mutually soluble and have similar boiling points. Also known as chromatography, it is commonly used in the processing of starch sugars and sugar alcohols, such as glucose syrup, malt syrup, brewing syrup, fructose syrup, sorbitol, and caramel colorings. For example, a chromatographic fractionation purification method for xylose mother liquor, disclosed in application number CN202111606217.3 on May 6, 2022, reduces the difficulty of chromatographic separation, lowers the performance requirements of the resin, allows for a wider range of resin selection, and has a lower initial investment. The device achieves high purity and efficient separation capabilities, recovering over 99% of the xylose components from the raw materials. The xylose content in the by-products sold externally can be controlled to below 5%, maximizing resource utilization. A chromatographic device for chromatographic purification, disclosed in application number CN201921651422.X on June 23, 2020, features a rotating shaft on the left side of the dispensing tube, with a cover fitted over the shaft. The cover has a groove corresponding to the shape of the dispensing tube. This structure does not hinder normal dispensing operations and also provides dust protection when the dispensing tube is not being used, preventing external dust from entering the dispensing bottle through the dispensing tube and thus avoiding any impact on the solvent in the dispensing bottle.

[0003] After the substances are separated by the chromatographic column, they are discharged sequentially through the needle or opening at the bottom of the column. However, when the column is in an inclined support environment, the tilted liquid surface will affect the accuracy of subsequent discharge purification. In addition, the chromatographic column is usually fixed, and the mixing uniformity between materials is relatively poor when adding mixed liquid or mobile phase, which reduces the overall purification effect. Summary of the Invention

[0004] The purpose of this invention is to provide a purification structure for a high-efficiency chromatographic separation device, in order to solve the problem that, in the purification structure of the chromatographic separation device proposed in the background art, after the substances are separated by the chromatographic column, the substances are discharged sequentially through the needle or opening at the lower end of the chromatographic column. However, when the chromatographic column is in an inclined support environment, the tube itself is tilted, and the tilted liquid surface will affect the purification accuracy of the subsequent discharge. In addition, the chromatographic column is generally fixed, and the mixing uniformity between materials is relatively poor when adding mixed liquid or mobile phase.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a purification structure for a high-efficiency chromatographic separation device, comprising a support base and a chromatographic column. The chromatographic column is disposed on the outside of the support base for separating and purifying the product. A clamping module is disposed on the outside of the chromatographic column to provide support for the column. A connecting rod is disposed on the outside of the clamping module, with its outer end disposed inside the support base to provide support for the clamping module. A liquid addition chamber is disposed above the chromatographic column and fixed above the support base. A drain port is installed below the liquid addition chamber. A connector is threadedly connected to the lower part of the drain port, and a connecting hose is fixed to the lower end of the connector. The lower end of the connecting hose is connected to the chromatographic column, allowing the chromatographic column to move below the liquid addition chamber. The left end of the connecting rod... A movable ball is fixed at one end and is rotatably mounted inside the support base. The vertical center line of the movable ball and the horizontal center line of the connecting rod are perpendicular to each other. A traction rope is fixed to the lower middle of the movable ball, and a counterweight is fixed to the lower end of the traction rope. The support base has a cavity to provide movement space for the counterweight. The movable ball is pulled to a vertical position by the counterweight, so that the chromatographic column can remain vertical during discharge. A first magnetic block is fixed to the outside of the counterweight, and a second magnetic block is set outside the first magnetic block. The counterweight is moved by the interaction force between the first and second magnetic blocks, which can control the shaking of the chromatographic column and accelerate the mixing of the liquid. A movement control mechanism is set outside the second magnetic block to control the movement of the second magnetic block and change the shaking direction of the counterweight.

[0006] To further optimize this technical solution, the clamping module includes a first clamping block, a second clamping block, a guide post, and a first spring;

[0007] The first clamping block has an arc-shaped structural design;

[0008] The second clamping block is located to the right of the first clamping block and is symmetrically arranged to the left and right sides of the first clamping block, providing clamping for the chromatographic column tube on both sides.

[0009] The guide post is fixed to the rear end of the first clamping block, and the right end of the guide post passes through the second clamping block to form a sliding connection between the second clamping block and the second clamping block. Two sets of guide posts are provided on the first clamping block.

[0010] The first spring, sleeved on the outside of the guide post, provides thrust to the second clamping block, enabling it to automatically move closer to the first clamping block, facilitating the subsequent removal and installation of the chromatographic column tube from the clamping module.

[0011] To further optimize this technical solution, both the inner sides of the first clamping block and the inner sides of the second clamping block are fixed with fitting pads, and the fitting pads are made of rubber material. Furthermore, the first clamping block and the connecting rod are fixedly connected, so that the clamping module can obtain stable support.

[0012] To further optimize this technical solution, a cover is installed above the liquid filling chamber, and a liquid filling port is provided above the cover. The cover and the liquid filling chamber are connected by a thread, which facilitates the subsequent removal of the cover to clean the inside of the liquid filling chamber.

[0013] To further optimize this technical solution, a sealing plug is installed inside the liquid filling chamber. The sealing plug is located above the drain outlet to block the drain outlet, and a control plate is fixed above the sealing plug. The upper end of the control plate passes through the cover and forms an up-and-down sliding structure. A fixing plate is fixed to the surface of the control plate, and a second spring is installed above the fixing plate. The second spring provides downward pressure to the fixing plate, so that the sealing plug keeps blocking the drain outlet. An auxiliary stirring mechanism is installed on the outside of the control plate, which can stir the liquid in the liquid filling chamber when the control plate moves.

[0014] To further optimize this technical solution, the auxiliary stirring mechanism includes a transmission gear, a movable shaft, a support plate, and a stirring rod;

[0015] The transmission gear is located on the outside of the control panel and forms a meshing connection with the control panel;

[0016] The movable shaft is fixed in the middle of the transmission gear, and there are two sets of movable shafts and transmission gears that are staggered on the left and right sides of the control panel.

[0017] A support plate is provided at the end of the movable shaft and forms a rotatable connection between the movable shaft and the movable shaft, providing support for the movable shaft, and the support plate is fixed below the cover.

[0018] To further optimize this technical solution, the first magnetic block and the second magnetic block are arranged with their magnetic poles of the same name facing each other, so that the first magnetic block can move under the repulsive force of the second magnetic block.

[0019] To further optimize this technical solution, the movement control mechanism includes a control ring, a rotating shaft, a motor telescoping device, a slider, a slide groove, and a transmission block;

[0020] The control ring is fixed to the outside of the second magnetic block to control the movement of the second magnetic block;

[0021] A rotating shaft passes through the middle of the control ring to control the rotation of the control ring, and the rotating shaft and the control ring form an up-and-down sliding structure;

[0022] The motor is connected to the rotating shaft to control its rotation;

[0023] The telescopic device is located below the control ring to control the height of the control ring.

[0024] The slider is positioned above the telescopic device, and its main cross-section has a "T" shaped structure design.

[0025] A sliding groove, in the form of a ring, is formed below the control ring, and a sliding connection is formed between the sliding groove and the slider;

[0026] The transmission block is fixed to the surface of the rotating shaft, and the rotating shaft drives the control ring to rotate through the transmission block.

[0027] To further optimize this technical solution, an auxiliary limiting mechanism is provided above the counterweight to limit the counterweight and keep the counterweight and chromatographic column tube stable.

[0028] To further optimize this technical solution, the auxiliary limiting mechanism includes a limiting plate, a top rod, a mounting plate, and an adjusting rod;

[0029] The limiting plate is fixed above the counterweight;

[0030] The push rods are evenly distributed above the limiting plate, and the upper end of the push rods penetrates the upper surface of the support base and forms an up-and-down sliding structure between the support base and the support base.

[0031] The mounting plate is fixed above the push rod to control its movement;

[0032] An adjusting rod is threaded through the mounting plate and the mounting plate together, and the adjusting rod is rotatably mounted on the upper surface of the support base.

[0033] Compared with the prior art, the beneficial effects of the present invention are:

[0034] (1) The purification structure of this high-efficiency chromatographic separation device provides vertical positioning effect for the connecting rod and clamping module through the movable ball and counterweight, so that the subsequent chromatographic column can remain vertical and unaffected by the external environment. The chromatographic column can also maintain vertical stability when subjected to external shaking or changes in the tilt of the support surface, which facilitates subsequent purification and improves its purification accuracy. In addition, the counterweight is also equipped with an auxiliary limiting mechanism, which can limit the counterweight to keep the chromatographic column stable and prevent the subsequent mobile equipment from shaking and bumping.

[0035] (2) The purification structure of this high-efficiency chromatographic separation device allows the counterweight to move by the mutual repulsion between the first and second magnetic blocks. The position of the second magnetic block is adjusted by the movement of the control ring, so that the counterweight can shake, thereby driving the movable ball to move. The movable ball drives the clamping module and the chromatographic column to move, which achieves the shaking effect on the chromatographic column and facilitates the full mixing of substances.

[0036] (3) The purification structure of this high-efficiency chromatographic separation device can drive the movable shaft to rotate by moving the control plate, and stir the liquid in the liquid addition chamber in conjunction with the stirring rod, so that the liquid in the liquid addition chamber can be automatically stirred when the seal is opened, so as to mix it evenly and increase the functionality of the device. Attached Figure Description

[0037] Figure 1 This is a three-dimensional structural diagram of the present invention;

[0038] Figure 2 This is a schematic diagram of the structure of the present invention from a bottom view;

[0039] Figure 3 This is a schematic diagram of the clamping module structure of the present invention;

[0040] Figure 4 This is a schematic diagram of the side section structure of the liquid addition chamber of the present invention;

[0041] Figure 5 This is a schematic diagram of the three-dimensional structure of the control board of the present invention;

[0042] Figure 6 This is a schematic diagram of the main cross-sectional structure of the support base of the present invention;

[0043] Figure 7 This is a schematic diagram of the control coil structure from below in this invention;

[0044] Figure 8 This is a schematic diagram of the main cross-sectional structure of the control loop of the present invention.

[0045] In the diagram: 1. Support base; 2. Chromatographic column tube; 3. Clamping module; 301. First clamping block; 302. Second clamping block; 303. Guide column; 304. First spring; 4. Connecting rod; 5. Liquid addition chamber; 6. Connecting hose; 7. Connector; 8. Drain port; 9. Cover; 10. Fitting pad; 11. Sealing plug; 12. Control panel; 13. Transmission gear; 14. Movable shaft; 15. Support plate; 16. Stirring rod; 17. Second spring; 18. Fixing plate; 19. Movable ball; 20. Traction rope; 21. Counterweight; 22. First magnetic block; 23. Second magnetic block; 24. Control ring; 25. Rotating shaft; 26. Motor; 27. Telescopic device; 28. Slider; 29. ​​Slide groove; 30. Transmission block; 31. Limiting plate; 32. Top rod; 33. Mounting plate; 34. Adjusting rod. Detailed Implementation

[0046] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0047] Please see Figures 1-8This invention provides a technical solution: a purification structure for a high-efficiency chromatographic separation device, including a support base 1 and a chromatographic column 2. The chromatographic column 2 is disposed on the outside of the support base 1 to separate and purify the product. A clamping module 3 is disposed on the outside of the chromatographic column 2 to provide support for the chromatographic column 2, and a connecting rod 4 is disposed on the outside of the clamping module 3. The outer end of the connecting rod 4 is disposed inside the support base 1 to provide support for the clamping module 3. A liquid addition chamber 5 is disposed above the chromatographic column 2 and is fixed above the support base 1. A drain port 8 is installed below the liquid addition chamber 5, and a connector 7 is threadedly connected to the lower part of the drain port 8. A connecting hose 6 is fixed to the lower end of the connector 7. The lower end of the connecting hose 6 is connected to the chromatographic column tube 2, allowing the chromatographic column tube 2 to move below the liquid addition chamber 5. A movable ball 19 is fixed to the left end of the connecting rod 4, and the movable ball 19 is rotatably mounted inside the support base 1. The vertical center line of the movable ball 19 and the horizontal center line of the connecting rod 4 are perpendicular to each other. A traction rope 20 is fixed to the lower middle of the movable ball 19, and a counterweight 21 is fixed to the lower end of the traction rope 20. The support base 1 has a cavity inside to provide movement space for the counterweight 21. The counterweight 21 pulls the movable ball 19 to a vertical position, ensuring that the chromatographic column tube 2 remains vertical during material discharge. A first magnetic block 22 is fixed to the outside of the counterweight 21. A second magnetic block 23 is provided on the outer side. The interaction force between the first magnetic block 22 and the second magnetic block 23 causes the counterweight 21 to move, which controls the shaking of the chromatographic column 2 and accelerates the mixing of the liquid. A movement control mechanism is provided on the outer side of the second magnetic block 23 to control the movement of the second magnetic block 23 and change the shaking direction of the counterweight 21. The clamping module 3 includes a first clamping block 301, a second clamping block 302, a guide post 303, and a first spring 304. The first clamping block 301 has an arc-shaped structure design. The second clamping block 302 is located on the right side of the first clamping block 301 and is symmetrically arranged to the left and right of the first clamping block 301 to provide clamping for the chromatographic column 2 on both sides. The guide post 303... The guide post 303 is fixed to the rear end of the first clamping block 301, and the right end of the guide post 303 passes through the second clamping block 302 to form a sliding connection between the second clamping block 302. The guide post 303 is provided with two sets of first springs 304 on the first clamping block 301, which are sleeved on the outside of the guide post 303 to provide thrust to the second clamping block 302 so that it can automatically move towards the first clamping block 301, which facilitates the subsequent removal and installation of the chromatographic column tube 2 from the clamping module 3. The inner side of the first clamping block 301 and the inner side of the second clamping block 302 are both fixed with a bonding pad 10, which is made of rubber. The first clamping block 301 and the connecting rod 4 are fixedly connected so that the clamping module 3 can obtain stable support.

[0048] In use, the chromatographic column tube 2 can be connected to the liquid addition chamber 5 via the connecting hose 6. The connector 7 at the upper end of the connecting hose 6 can be connected to the drain port 8. Then, the chromatographic column tube 2 can be installed on the clamping module 3 for positioning. During installation, the second clamping block 302 can be pulled to move it along the guide column 303 and compress the first spring 304. Then, the chromatographic column tube 2 can be placed inside the first clamping block 301 and the second clamping block 302. The second clamping block 302 can be released to move under the action of the first spring 304 to clamp and position the chromatographic column tube 2. After the chromatographic column tube 2 is installed, the counterweight 21 provides a downward pulling force to the movable ball 19 through the traction rope 20. The movable ball 19 provides support to the clamping module 3 through the connecting rod 4, so that the clamping module 3 and the chromatographic column tube 2 can remain in a vertical state.

[0049] A cover 9 is installed above the filling chamber 5, and a filling port is provided on the top of the cover 9. The cover 9 and the filling chamber 5 are connected by a thread, which facilitates the removal of the cover 9 for cleaning the inside of the filling chamber 5. A sealing plug 11 is installed inside the filling chamber 5. The sealing plug 11 is located above the drain port 8 and seals the drain port 8. A control plate 12 is fixed above the sealing plug 11. The upper end of the control plate 12 passes through the cover 9 and forms a sliding structure between the cover 9 and the cover 9. A fixing plate 18 is fixed to the surface of the control plate 12. A second spring 17 is provided above the fixing plate 18. The second spring 17 provides downward pressure to the fixing plate 18, so that the sealing plug 11 keeps the drain port 8 closed. To prevent the sealing, an auxiliary stirring mechanism is provided on the outside of the control plate 12. When the control plate 12 moves, it can stir the liquid in the liquid addition chamber 5. The auxiliary stirring mechanism includes a transmission gear 13, a movable shaft 14, a support plate 15, and a stirring rod 16. The transmission gear 13 is set on the outside of the control plate 12 and forms a meshing connection with the control plate 12. The movable shaft 14 is fixed in the middle of the transmission gear 13, and the movable shaft 14 and the transmission gear 13 are distributed in two sets on the left and right sides of the control plate 12, alternating vertically. The support plate 15 is set at the end of the movable shaft 14 and forms a rotatable connection with the movable shaft 14, providing support for the movable shaft 14. The support plate 15 is fixed below the cover 9.

[0050] When liquid needs to be added to the chromatographic column 2 through the addition chamber 5, the control plate 12 can be pulled to move the sealing plug 11, opening the drain port 8. At the same time, when the control plate 12 moves, it will drive the movable shaft 14 to rotate through the meshing of the transmission gear 13. The movable shaft 14 drives the stirring rod 16 to rotate, stirring the liquid in the addition chamber 5 to make it evenly mixed. After the addition is completed, the control plate 12 is released, and the second spring 17 pushes the control plate 12 downward through the fixing plate 18, so that the sealing plug 11 continues to seal the drain port 8. Subsequently, the cover 9 can also be removed from the addition chamber 5 by rotation, taking out the control plate 12 and the movable shaft 14 at the same time for easy cleaning.

[0051] The first magnetic block 22 and the second magnetic block 23 are arranged with their same magnetic poles facing each other, allowing the first magnetic block 22 to move under the repulsive force of the second magnetic block 23. The movement control mechanism includes a control ring 24, a rotating shaft 25, a motor 26, a telescopic device 27, a slider 28, a slide groove 29, and a transmission block 30. The control ring 24 is fixed to the outside of the second magnetic block 23 to control its movement. The rotating shaft 25 passes through the middle of the control ring 24 to control its rotation, and the rotating shaft 25 and the control ring 24 form an up-and-down sliding structure. The motor 26 is connected to the rotating shaft 25 to control its rotation. The telescopic device 27 is located below the control ring 24 to control its height. The slider 28 is located above the telescopic device 27, and its main cross-section has a "T" shape. The slide groove 29 is annularly formed in the control ring 24. Below 4, and a sliding connection is formed between the slide groove 29 and the slider 28. The transmission block 30 is fixed on the surface of the rotating shaft 25. The rotating shaft 25 drives the control ring 24 to rotate through the transmission block 30. An auxiliary limiting mechanism is provided above the counterweight 21 to limit the counterweight 21 and keep the counterweight 21 and the chromatographic column tube 2 stable. The auxiliary limiting mechanism includes a limiting plate 31, a top rod 32, a mounting plate 33 and an adjusting rod 34. The limiting plate 31 is fixed above the counterweight 21. The top rod 32 is distributed at equal angles above the limiting plate 31, and the upper end of the top rod 32 passes through the upper surface of the support seat 1 and forms an up-and-down sliding structure with the support seat 1. The mounting plate 33 is fixed above the top rod 32 to control the movement of the top rod 32. The adjusting rod 34 passes through the mounting plate 33 and forms a threaded connection with the mounting plate 33. The adjusting rod 34 is rotatably mounted on the upper surface of the support seat 1.

[0052] When it is necessary to control the shaking of the chromatographic column 2 to improve the uniformity of liquid mixing, the control ring 24 can be pushed upward by the extension and retraction of the telescopic device 27, so that the second magnetic block 23 and the first magnetic block 22 are opposite each other, pushing the first magnetic block 22 to move. At the same time, the motor 26 can be started, which drives the rotating shaft 25 to rotate. The rotating shaft 25 drives the control ring 24 to rotate through the transmission block 30. The control ring 24 drives the second magnetic block 23 to move outside the counterweight 21, changing the direction of the repulsive force it provides to the counterweight 21. The counterweight 21 is shaken, which in turn moves the movable ball 19 and the chromatographic column 2, achieving a shaking effect on the chromatographic column 2. When it is necessary to maintain the stability of the chromatographic column 2 and the counterweight 21, the adjusting rod 34 can be rotated so that it moves the mounting plate 33 through the threaded connection between the rod and the mounting plate 33. The mounting plate 33 moves the push rod 32, controlling the push rod 32 to move downward, contact and press against the limiting plate 31, limiting the counterweight 21, while the position of the movable ball 19 will also remain stable.

[0053] The contents not described in detail in this specification are existing technologies known to those skilled in the art.

[0054] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A purification structure for a high-efficiency chromatographic separation device, comprising a support base (1) and a chromatographic column (2), wherein the chromatographic column (2) is disposed on the outside of the support base (1) to separate and purify the product; Its features are: A clamping module (3) is provided on the outside of the chromatographic column tube (2) to provide support for the chromatographic column tube (2). A connecting rod (4) is provided on the outside of the clamping module (3). The outer end of the connecting rod (4) is located inside the support base (1) to provide support for the clamping module (3). A liquid addition chamber (5) is provided above the chromatographic column tube (2). The liquid addition chamber (5) is fixed above the support base (1). A drain port (8) is installed below the liquid addition chamber (5). A connector (7) is threaded below the drain port (8). A connecting hose (6) is fixed at the lower end of the connector (7). The lower end of the connecting hose (6) is connected to the chromatographic column tube (2) so that the chromatographic column tube (2) can move below the liquid addition chamber (5). A movable ball (19) is fixed at the left end of the connecting rod (4). The movable ball (19) is rotatably installed inside the support base (1). The vertical center line of the movable ball (19) is... The horizontal center line of the connecting rod (4) is perpendicular to each other. A traction rope (20) is fixed at the lower middle of the movable ball (19), and a counterweight (21) is fixed at the lower end of the traction rope (20). The support base (1) has a cavity inside that provides space for the counterweight (21) to move. The movable ball (19) is pulled to a vertical position by the counterweight (21), so that the chromatographic column (2) can remain vertical when discharging. A first magnetic block (22) is fixed on the outside of the counterweight (21), and a second magnetic block (23) is provided on the outside of the first magnetic block (22). The counterweight (21) is moved by the interaction force between the first magnetic block (22) and the second magnetic block (23), which can control the chromatographic column (2) to shake and accelerate the mixing of the liquid. A movement control mechanism is provided on the outside of the second magnetic block (23) to control the movement of the second magnetic block (23) and change the shaking direction of the counterweight (21). The first magnetic block (22) and the second magnetic block (23) are arranged with their magnetic poles facing each other, so that the first magnetic block (22) can move under the repulsive force of the second magnetic block (23); The movement control mechanism includes a control ring (24), a rotating shaft (25), a motor (26), an extension device (27), a slider (28), a slide groove (29), and a transmission block (30). The control ring (24) is fixed to the outside of the second magnetic block (23) to control the movement of the second magnetic block (23); The rotating shaft (25) passes through the middle of the control ring (24) to control the rotation of the control ring (24), and the rotating shaft (25) and the control ring (24) form an up-and-down sliding structure; The motor (26) is connected to the rotating shaft (25) to control the rotation of the rotating shaft (25); The telescopic device (27) is located below the control ring (24) to control the height position of the control ring (24); The slider (28) is positioned above the telescopic device (27), and the main view section of the slider (28) is designed with a "T" shape. A groove (29) is formed in a circular shape below the control ring (24), and a sliding connection is formed between the groove (29) and the slider (28); The transmission block (30) is fixed on the surface of the rotating shaft (25), and the rotating shaft (25) drives the control ring (24) to rotate through the transmission block (30); An auxiliary limiting mechanism is provided above the counterweight (21) to limit the counterweight (21) and keep the counterweight (21) and the chromatographic column (2) stable. The auxiliary limiting mechanism includes a limiting plate (31), a top rod (32), a mounting plate (33), and an adjusting rod (34). The limiting plate (31) is fixed above the counterweight (21); The top rod (32) is distributed at equal angles above the limiting plate (31), and the upper end of the top rod (32) passes through the upper surface of the support seat (1) and forms an up-and-down sliding structure between the support seat (1); Mounting plate (33) is fixed above top rod (32) to control the movement of top rod (32); The adjusting rod (34) passes through the mounting plate (33) and forms a threaded connection between the mounting plate (33), and the adjusting rod (34) is rotatably mounted on the upper surface of the support base (1).

2. The purification structure of the high-efficiency chromatographic separation device according to claim 1, characterized in that: The clamping module (3) includes a first clamping block (301), a second clamping block (302), a guide post (303), and a first spring (304). The first clamping block (301) has an arc-shaped structural design; The second clamp (302) is set to the right of the first clamp (301) and is symmetrically arranged to the left and right of the first clamp (301) to provide clamping for the chromatographic column tube (2) on both sides. The guide post (303) is fixed to the rear end of the first clamping block (301), and the right end of the guide post (303) passes through the second clamping block (302) and forms a sliding connection between the second clamping block (302). Two sets of guide posts (303) are provided on the first clamping block (301). The first spring (304) is sleeved on the outside of the guide post (303) to provide thrust to the second clamping block (302), so that it can automatically move closer to the first clamping block (301).

3. The purification structure of the high-efficiency chromatographic separation device according to claim 2, characterized in that: The inner side of the first clamping block (301) and the inner side of the second clamping block (302) are both fixed with a bonding pad (10), and the bonding pad (10) is made of rubber material. The first clamping block (301) and the connecting rod (4) are fixedly connected.

4. The purification structure of the high-efficiency chromatographic separation device according to claim 1, characterized in that: A cover (9) is installed above the liquid filling chamber (5), and a liquid filling port is provided above the cover (9). The cover (9) and the liquid filling chamber (5) are connected by a thread.

5. The purification structure of a high-efficiency chromatographic separation device according to claim 4, characterized in that: The liquid filling chamber (5) is equipped with a sealing plug (11), which is located above the drain port (8) to block the drain port (8). A control plate (12) is fixed above the sealing plug (11). The upper end of the control plate (12) passes through the cover (9) and forms an up-and-down sliding structure between the cover (9). A fixing plate (18) is fixed on the surface of the control plate (12). A second spring (17) is provided above the fixing plate (18). The second spring (17) provides downward pressure to the fixing plate (18) so that the sealing plug (11) keeps blocking the drain port (8). An auxiliary stirring mechanism is provided on the outside of the control plate (12). When the control plate (12) moves, it can stir the liquid in the liquid filling chamber (5).

6. The purification structure of a high-efficiency chromatographic separation device according to claim 5, characterized in that: The auxiliary stirring mechanism includes a transmission gear (13), a movable shaft (14), a support plate (15), and a stirring rod (16). The transmission gear (13) is disposed on the outside of the control plate (12) and forms a meshing connection between the control plate (12) and the control plate (12); The movable shaft (14) is fixed in the middle of the transmission gear (13), and the movable shaft (14) and the transmission gear (13) are distributed in two sets on the left and right sides of the control plate (12) in an alternating manner. A support plate (15) is provided at the end of the movable shaft (14) and forms a rotatable connection between the movable shaft (14) and the movable shaft (14), providing support for the movable shaft (14), and the support plate (15) is fixed below the cover (9).

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