Equipment and method for preparing whitening and spot-lightening composition suitable for sensitive skin

Abstract

The present invention provides a preparation device for a whitening and lightening composition suitable for sensitive skin and a preparation method thereof, and relates to the technical field of preparation of whitening and lightening compositions, including a kettle body and an adjusting device, wherein the lower surface of the kettle body is fixedly connected to a plurality of support columns used to make the kettle body, the lower surface of the kettle body is fixedly connected to a discharge pipe, a valve is installed on the arc surface of the discharge pipe, the arc surface of the kettle body is fixedly connected to a heating pipe, the arc surface of the kettle body is fixedly connected to a heat dissipation pipe, the upper surface of the kettle body is fixedly connected to a feed pipe for feeding, the upper surface of the kettle body is fixedly connected to a servo motor, and the output end of the servo motor is fixedly connected to a round rod. According to the present invention, the filter plate and the filter hole can filter the precipitate in the preparation process, thereby avoiding the accumulation of the precipitate inside the kettle body, and the precipitate on the filter plate can be conveniently processed after the filtration is completed, so that the preparation process is more efficient and the downtime caused by blockage is reduced.

Description

Technical Field

[0001] The invention relates to the technical field of preparation of whitening and spot-lightening compositions, and in particular to equipment and a preparation method of the whitening and spot-lightening compositions suitable for sensitive skin. Background Art

[0002] Most whitening products on the current market only add whitening ingredients that consider the whitening effect, without considering the skin tolerance of consumers with sensitive skin, which can easily lead to allergies.

[0003] The invention with publication number CN105919828B discloses a whitening and freckle-removing composition, a preparation method and its application. The technical scheme thereof includes: active ingredients and auxiliary ingredients, wherein the active ingredients include 1-25% glutathione, 0.1-2% VC, 0.1-2% arbutin, 0.01-0.2% biotin, and the remainder is auxiliary ingredients. The present invention uses glutathione, VC, arbutin and biotin in combination, and the synergistic effect is very obvious. It is stored without water, and its efficacy is not affected within the shelf life of 36 months. It is activated with water before use, and is easy to use.

[0004] With regard to the relevant contents mentioned above, the following technical defects were found: when a reaction kettle is needed to prepare a whitening and freckle-removing composition, the raw materials are first poured into the kettle body along the feed pipe in sequence, and then the servo motor is started to drive the round rod to rotate, and the round rod drives the stirring rod to stir and mix the raw materials inside the kettle body, and finally the valve is opened to allow the mixed raw materials to be discharged from the discharge pipe. Precipitation will be generated during the preparation process. If the precipitate is not handled in time, it will easily cause the precipitate to accumulate inside the reaction kettle, which will affect the normal use of the whitening and freckle-removing composition preparation equipment. Summary of the invention

[0005] The purpose of the present invention is to solve the shortcomings of the prior art and to propose a preparation device and a preparation method of a whitening and spot-removing composition suitable for sensitive skin.

[0006] In order to achieve the above-mentioned purpose, the present invention adopts the following technical scheme: a preparation device for a whitening and freckle-removing composition suitable for sensitive skin and a preparation method thereof, comprising a kettle body and an adjusting device, wherein the lower surface of the kettle body is fixedly connected to a plurality of support columns used to make the kettle body, the lower surface of the kettle body is fixedly connected to a discharge pipe, the arc surface of the discharge pipe is installed with a valve, the arc surface of the kettle body is fixedly connected to a heating pipe, the arc surface of the kettle body is fixedly connected to a heat dissipation pipe, the upper surface of the kettle body is fixedly connected to a feeding pipe for feeding, the upper surface of the kettle body is fixedly connected to a servo motor, the output end of the servo motor is fixedly connected to a round rod, the arc surface of the round rod is fixedly connected to a stirring rod for stirring, the adjusting device is located on the inner wall of the kettle body, the adjusting device is used to filter the precipitate generated during the preparation process, the adjusting device comprises a filter plate, the filter plate is fixedly connected to the inner wall of the kettle body, the filter plate is rotatably connected to the round rod, a plurality of filter holes are provided on the surface of the filter plate, a groove is provided on the upper surface of the filter plate, and the cross-section of the groove is fan-shaped, the kettle body The inner wall of the filter plate is fixedly connected with an annular rail, the inner wall of the annular rail is slidably connected with a sliding plate, the lower surface of the sliding plate is fixedly connected with a scraper for scraping the sediment on the filter plate into the groove, the lower surface of the scraper is in contact with the upper surface of the filter plate, one side of the sliding plate is fixedly connected with a first circular arc plate, the inner wall of the first circular arc plate is in contact with the circular arc surface of the round rod, one side of the first circular arc plate is rotatably connected with a screw rod, the other side of the first circular arc plate is fixedly connected with a motor for driving the screw rod to rotate, the output end of the motor is connected to the The screw rod is fixedly connected, and the outer sleeve of the motor is provided with a waterproof cover for waterproofing, one side of the waterproof cover is fixedly connected to the arc plate, the arc surface of the screw rod is threadedly connected to the second arc plate, the inner wall of the first arc plate is fixedly connected to a rubber pad, the outer wall of the kettle body is provided with an outlet hole, the inner wall of the outlet hole is fitted with a baffle for sealing the outlet hole, the outer wall of the kettle body is fixedly connected to an electric push rod for controlling the movement of the baffle, the output end of the electric push rod is fixedly connected to a connecting plate, and one side of the long arm end of the connecting plate is fixedly connected to the baffle.

[0007] The effects achieved by the above components are: by setting the adjustment device, the filter plate and the filter holes can filter the precipitate during the preparation process, thereby avoiding the accumulation of the precipitate inside the kettle body, and the precipitate on the filter plate can be conveniently processed after the preparation is completed, making the preparation process more efficient and reducing the downtime caused by blockage. The precipitate can be easily removed from the filter plate after the preparation is completed, thereby improving the preparation efficiency of the whitening and spot-removing composition.

[0008] Preferably, both sides of the sliding plate are fixedly connected with connecting frames, one side of the connecting frame is fixedly connected with a scraper for scraping dirt on the inner wall of the kettle body, and one side of the scraper is in contact with the inner wall of the kettle body.

[0009] The effect achieved by the above components is that when the sliding plate drives the scraper to rotate, it will also drive the connecting frame and the scraper to rotate along the inner wall of the kettle body, so that the dirt attached to the inner wall of the kettle body can be scraped off.

[0010] Preferably, a scraper ring is fixedly connected to a side of the baffle away from the connecting plate, the scraper ring has a fan-shaped cross section, and the lower surface of the scraper ring fits with the bottom of the inner wall of the groove.

[0011] The effect achieved by the above components is that the baffle plate can drive the scraper ring during its movement, so that the scraper ring scrapes off the sediment in the groove along the outlet hole.

[0012] Preferably, the adjusting device also includes a dirt collecting box for storing sediment, a handle for controlling the dirt collecting box is fixedly connected to one side of the dirt collecting box, positioning plates are fixedly connected to both sides of the outer wall of the dirt collecting box, a pressure rod is threadedly penetrated through the upper surface of the positioning plate, a positioning rod is slidably penetrated through the side surface of the positioning plate, and one end of the positioning rod is fixedly connected to the outer wall of the kettle body.

[0013] The effect achieved by the above components is that by setting the above structure, the sediment scraped by the scraper ring can be collected using the dirt collecting box, and the dirt collecting box can be easily disassembled and assembled, thereby facilitating personnel to centrally transport the sediment in the dirt collecting box.

[0014] Preferably, the end of the positioning rod away from the kettle body has a conical structure.

[0015] The effect achieved by the above components is that by setting one end of the positioning rod as a conical structure, the positioning plate can be easily sleeved on the arc surface of the positioning rod.

[0016] Preferably, a sealing ring for sealing a gap between the baffle plate and the kettle body is fixedly connected to a side of the baffle plate away from the kettle body, and one side of the sealing ring is in contact with an outer wall of the kettle body.

[0017] The effect achieved by the above components is that the sealing ring can block the gap between the baffle plate and the kettle body, thereby improving the sealing between the baffle plate and the kettle body.

[0018] Preferably, a guide rod for guiding and positioning the second circular arc plate is slidably penetrated through the side surface of the second circular arc plate, and one end of the guide rod is fixedly connected to the first circular arc plate.

[0019] The effect achieved by the above components is that when the screw rod drives the second arc surface to move, the guide rod can guide and position the second arc plate, thereby preventing the second arc plate from rotating and deviating during its movement.

[0020] Preferably, the outer wall of the feed pipe is provided with an auxiliary device for sealing the feed pipe, the auxiliary device includes a fixed seat, one side of the fixed seat is fixedly connected to the outer wall of the feed pipe, the inner wall of the fixed seat is rotatably connected to a connecting plate, one side of the connecting plate is fixedly connected to a cover plate, the diameter of the cover plate is larger than the diameter of the feed pipe, a sliding hole is opened on one side of the fixed seat, the center of the sliding hole is coaxial with the axis of rotation of the connecting plate, the inner wall of the sliding hole is slidably connected to a sliding rod, one end of the sliding rod is fixedly connected to the connecting plate, and the arc surface of the sliding rod is threadedly connected to an adjustment ring for fixing the connecting plate.

[0021] The effect achieved by the above components is: by setting up auxiliary devices, personnel can easily adjust the cover to open and close and seal the feed pipe, which improves the convenience of the feeding process and improves the practicality of the whitening and freckle-removing composition preparation equipment and preparation method suitable for sensitive skin.

[0022] Preferably, a gasket is fixedly connected to one side of the adjustment ring close to the fixing seat, and the gasket is specifically made of rubber material.

[0023] The effect achieved by the above components is that the gasket can increase the friction force of the adjusting ring on the side close to the fixing seat, so that the adjusting ring can be firmly abutted against the fixing seat with the help of the gasket.

[0024] A preparation method of a whitening and spot-lightening composition suitable for sensitive skin,

[0025] The components include nicotinamide, tranexamic acid, glabridin, nonapeptide-1, and mango fruit extract. In terms of mass fractions, the following are included:

[0026] Niacinamide: 0.1-10 parts

[0027] Tranexamic acid: 0.1-10 parts

[0028] Glabridin composition: 0.001-2 parts

[0029] Nonapeptide-1 composition: 0.1-10 parts

[0030] Mango fruit extract composition: 0.1-10 parts

[0031] Mixing niacinamide, tranexamic acid, glabridin composition, nonapeptide-1 composition, and mango fruit extract composition in a container, and then stirring and dissolving at a temperature of 30-40° C. to prepare a whitening and spot-lightening composition;

[0032] The composition is specifically used as an essence water, which is composed of the following percentage components: 5% 1,3-propylene glycol, 0.2% acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, 0.2% arginine, an appropriate amount of preservatives, a whitening and spot-lightening composition suitable for sensitive skin (Examples 1-3), and the balance water;

[0033] Preparation process of essence water:

[0034] Add water, 1,3-propylene glycol, acrylates / C10-30 alkyl acrylate crosspolymer and sodium hyaluronate into an emulsifying pot, stir and heat to 80-85°C, keep stirring for 10 minutes, turn on medium speed and homogenize until there are no particles; cool to 60°C, add arginine and stir evenly; cool to below 40°C, add appropriate amount of preservatives, and stir evenly.

[0035] S1. The glabridin composition is composed of glabridin / 10% and cyclodextrin / 90%. The nonapeptide-1 composition is composed of water / 10%-40%, glycerol / 60%-90%, nonapeptide-1 / 0.045%-0.06%. The mango fruit extract composition is composed of water / 62.5%-67.5%, glycerol / 25%-30%, and mango (MANGIFERA INDICA) fruit extract / 6.5%-8.5%.

[0036] S2. Preparation method of nicotinamide:

[0037] S21, 3-cyanopyridine is melted and then transferred to a reaction kettle for hydrolysis reaction with a sodium hydroxide solution;

[0038] S22, 3-cyanopyridine is hydrolyzed by sodium hydroxide, filtered through activated carbon, candle filter, etc., and evaporated and concentrated at a temperature of 65°C and a pressure of 580-630 mm Hg;

[0039] S23, then reacting with aqueous ammonia to undergo an ammonolysis reaction;

[0040] S24, the obtained product is sent to the laboratory for quality inspection after crystallization, centrifugation, wet grinding and sieving;

[0041] S25. The product is qualified if the nicotinic acid content is less than 100 ppm by HPLC detection method;

[0042] S3. Preparation method of tranexamic acid:

[0043] S31, heating and dissolving p-carboxybenzylamine in an aqueous sulfuric acid solution;

[0044] S32, using platinum oxide as a catalyst, introducing nitrogen and hydrogen (0.5-1 kg / m2), and adding calcium hydroxide for neutralization after the reaction is completed;

[0045] S33, filtering and concentrating to obtain cis-p-aminomethylcyclohexanecarboxylic acid;

[0046] S34, add calcium hydroxide, increase pressure and temperature for 14 hours, and neutralize with dilute sulfuric acid to pH 5.5-5.6;

[0047] S35, decolorizing with activated carbon, crystallizing with ethanol, and obtaining the target product p-aminomethylcyclohexanecarboxylic acid (trans), which is tranexamic acid;

[0048] S4. Preparation method of glabridin composition:

[0049] S41. Pick the mature roots of Glycyrrhiza glabra and wash them thoroughly;

[0050] S42, crushing by a crusher;

[0051] S43, extraction;

[0052] S44, chromatography;

[0053] S45, vacuum drying after crystallization, and dissolving again;

[0054] S46, encapsulating the active substance with cyclodextrin;

[0055] S47, the obtained product is filtered, concentrated, vacuum dried, crushed, sieved and then sent for quality inspection;

[0056] S48. The product is qualified if the content of glabridin is ≥10% by HPLC detection method;

[0057] S5. Preparation method of nonapeptide-1 composition:

[0058] S51, synthesis;

[0059] S52, purification;

[0060] S53, concentration;

[0061] S54, freeze-dried;

[0062] S55, dissolving the polypeptide substance, adding glycerol, and preparing with sterile deionized water to obtain a solution of corresponding concentration;

[0063] S6. Preparation method of mango fruit extract composition:

[0064] S61, pick the mangoes and wash them thoroughly;

[0065] S62, separating the pulp by a separator;

[0066] S63, adding enzymatic hydrolysis to extract the mango fruit extract;

[0067] S64, performing solid / liquid separation;

[0068] S65. Finally, test for pesticide residues, allergens, and heavy metals.

[0069] Compared with the prior art, the advantages and positive effects of the present invention are:

[0070] 1. In the present invention, when a reaction kettle is needed to prepare a whitening and spot-lightening composition, the raw materials are first poured into the kettle body in sequence along the feed pipe, and then the servo motor is started to drive the round rod to rotate, and the round rod drives the stirring rod to stir and mix the raw materials in the kettle body, and finally the valve is opened to discharge the mixed raw materials from the discharge pipe. Precipitate will be generated during the preparation process. In order to prevent the discharge pipe from being blocked by the precipitate, the filter holes on the filter plate can filter the precipitate. By setting an adjusting device, the filter plate and the filter holes can filter the precipitate during the preparation process, thereby preventing the precipitate from accumulating inside the kettle body, and after the filtration is completed, the precipitate on the filter plate can be conveniently processed, making the preparation process more efficient and reducing the downtime caused by blockage.

[0071] 2. In the present invention, by providing an auxiliary device, personnel can conveniently adjust the cover plate to open and close the feed tube to seal it, thereby improving the convenience of the feeding process and the practicability of the preparation equipment and preparation method of the whitening and spot-removing composition suitable for sensitive skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0072] Figure 1 The present invention provides a schematic diagram of the three-dimensional structure of a preparation device and a preparation method of a whitening and spot-lightening composition suitable for sensitive skin;

[0073] Figure 2 This is a partial structural schematic diagram of the equipment and method for preparing the whitening and spot-lightening composition suitable for sensitive skin proposed in the present invention;

[0074] Figure 3 This is a schematic diagram of the structure of the regulating device of the preparation device of the whitening and spot-lightening composition suitable for sensitive skin and the preparation method thereof proposed by the present invention;

[0075] Figure 4 This is a partial structural schematic diagram of the regulating device of the preparation device of the whitening and spot-lightening composition suitable for sensitive skin and the preparation method thereof proposed in the present invention;

[0076] Figure 5 The present invention proposes a preparation device and a preparation method of a whitening and spot-removing composition suitable for sensitive skin Figure 4 A magnified view of point B;

[0077] Figure 6 The present invention proposes a preparation device and a preparation method of a whitening and spot-removing composition suitable for sensitive skin Figure 4 Enlarged view of point C;

[0078] Figure 7 This is a schematic diagram of the structure of a dirt collection box for the device and method for preparing a whitening and spot-lightening composition suitable for sensitive skin proposed in the present invention;

[0079] Figure 8 This is a schematic diagram of the structure of the auxiliary device of the preparation device of the whitening and spot-lightening composition suitable for sensitive skin and the preparation method thereof proposed by the present invention;

[0080] Fig. 9 The present invention proposes a preparation device and a preparation method of a whitening and spot-removing composition suitable for sensitive skin Figure 8 Enlarged view of point A.

[0081] Figure numerals: 1, kettle body; 2, support column; 3, adjustment device; 301, filter plate; 302, groove; 303, ring rail; 304, sliding plate; 305, scraper; 306, first arc plate; 307, motor; 308, waterproof cover; 309, screw rod; 310, second arc plate; 311, guide rod; 312, rubber pad; 313, connecting frame; 314, scraper; 315, outlet hole; 316, baffle; 317, electric push rod; 318, Connecting plate; 319, sealing ring; 320, scraper ring; 321, dirt collecting box; 322, handle; 323, positioning plate; 324, pressure rod; 325, positioning rod; 4, auxiliary device; 41, fixing seat; 42, connecting plate; 43, cover plate; 44, sliding hole; 45, sliding rod; 46, adjusting ring; 47, gasket; 5, discharge pipe; 6, valve; 7, heating pipe; 8, heat dissipation pipe; 9, feed pipe; 10, servo motor; 11, round rod; 12, stirring rod. DETAILED DESCRIPTION

[0082] In order to more clearly understand the above-mentioned purpose, features and advantages of the present invention, the present invention is further described below in conjunction with the accompanying drawings and embodiments. It should be noted that the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.

[0083] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways than those described herein. Therefore, the present invention is not limited to the specific embodiments of the following disclosure.

[0084] Embodiment 1, as Figure 1-9As shown, the present invention provides a preparation device for a whitening and freckle-removing composition suitable for sensitive skin and a preparation method thereof, comprising a kettle body 1 and an adjusting device 3, the lower surface of the kettle body 1 is fixedly connected to a plurality of support columns 2 used to form the kettle body 1, the lower surface of the kettle body 1 is fixedly connected to a discharge pipe 5, the arc surface of the discharge pipe 5 is installed with a valve 6, the arc surface of the kettle body 1 is fixedly connected to a heating pipe 7, the arc surface of the kettle body 1 is fixedly connected to a heat dissipation pipe 8, the upper surface of the kettle body 1 is fixedly connected to a feed pipe 9 for feeding, the upper surface of the kettle body 1 is fixedly connected to a servo motor 10, the output end of the servo motor 10 is fixedly connected to a round rod 11, the arc surface of the round rod 11 is fixedly connected to a stirring rod 12 for stirring, the adjusting device 3 is located on the inner wall of the kettle body 1, and the outer wall of the feed pipe 9 is provided with an auxiliary device 4 for sealing the feed pipe 9.

[0085] The specific settings and functions of the adjustment device 3 and the auxiliary device 4 are described in detail below.

[0086] like Figures 2 to 9As shown, the regulating device 3 is used to filter the precipitate generated during the preparation process, and the regulating device 3 includes a filter plate 301, the filter plate 301 is fixedly connected to the inner wall of the kettle body 1, the filter plate 301 is rotatably connected to the round rod 11, a plurality of filter holes are provided on the surface of the filter plate 301, a groove 302 is provided on the upper surface of the filter plate 301, and the cross section of the groove 302 is fan-shaped, the inner wall of the kettle body 1 is fixedly connected to an annular rail 303, the inner wall of the annular rail 303 is slidably connected to a sliding plate 304, the lower surface of the sliding plate 304 is fixedly connected to a scraper 305 for scraping the precipitate on the filter plate 301 into the groove 302, the lower surface of the scraper 305 is in contact with the upper surface of the filter plate 301, and one side of the sliding plate 304 is fixedly connected to a first arc plate 306, and the first arc plate 30 The inner wall of the first arc plate 306 is fitted with the arc surface of the round rod 11, one side of the first arc plate 306 is rotatably connected with a screw rod 309, the other side of the first arc plate 306 is fixedly connected with a motor 307 for driving the screw rod 309 to rotate, the output end of the motor 307 is fixedly connected with the screw rod 309, the outer sleeve of the motor 307 is provided with a waterproof cover 308 for waterproofing, one side of the waterproof cover 308 is fixedly connected with the arc plate, the arc surface of the screw rod 309 is threadedly connected with a second arc plate 310, the inner wall of the first arc plate 306 is fixedly connected with a rubber pad 312, the outer wall of the kettle body 1 is provided with an outlet hole 315, the inner wall of the outlet hole 315 is fitted with a baffle 316 for sealing the outlet hole 315, and the outer wall of the kettle body 1 is fixedly connected with an electric push rod 306 for controlling the movement of the baffle 316 17. The output end of the electric push rod 317 is fixedly connected to a connecting plate 318, and one side of the long arm end of the connecting plate 318 is fixedly connected to the baffle 316. By setting the adjusting device 3, the filter plate 301 and the filter hole can filter the sediment in the preparation process, thereby preventing the sediment from accumulating inside the kettle body 1, and after the filtration is completed, the sediment on the filter plate 301 can be conveniently processed, making the preparation process more efficient and reducing the downtime caused by blockage. Both sides of the sliding plate 304 are fixedly connected to a connecting frame 313, and one side of the connecting frame 313 is fixedly connected to a scraper 314 for scraping off the dirt on the inner wall of the kettle body 1. One side of the scraper 314 is in contact with the inner wall of the kettle body 1. When the sliding plate 304 drives the scraper 305 to rotate, it will also drive The connecting frame 313 and the scraper 314 rotate along the inner wall of the kettle body 1, so as to scrape off the dirt attached to the inner wall of the kettle body 1. The side of the baffle 316 away from the connecting plate 318 is fixedly connected with a scraper ring 320. The cross-section of the scraper ring 320 is fan-shaped. The lower surface of the scraper ring 320 fits with the bottom of the inner wall of the groove 302. The baffle 316 can drive the scraper ring 320 during the movement, so that the scraper ring 320 scrapes off the sediment in the groove 302 along the outlet hole 315. The adjustment device 3 also includes a dirt collecting box 321 for storing sediment. One side of the dirt collecting box 321 is fixedly connected to a handle 322 for controlling the dirt collecting box 321. Both sides of the outer wall of the dirt collecting box 321 are fixedly connected with positioning plates 323. The upper surface of the positioning plate 323 is threaded with a pressure rod 324.A positioning rod 325 is slidably provided on the side of the positioning plate 323, and one end of the positioning rod 325 is fixedly connected to the outer wall of the kettle body 1. By setting the above structure, the sediment scraped by the scraper ring 320 can be collected by using the dirt collecting box 321, and the dirt collecting box 321 can be easily disassembled and assembled, so as to facilitate personnel to centrally transport the sediment in the dirt collecting box 321. The end of the positioning rod 325 away from the kettle body 1 is a conical structure. By setting one end of the positioning rod 325 to a conical structure, the positioning plate 323 can be easily sleeved on the arc surface of the positioning rod 325. The side of the baffle plate 316 away from the kettle body 1 is fixedly connected to the baffle plate 316 for sealing. The sealing ring 319 of the gap between the kettle body 1, one side of the sealing ring 319 is in contact with the outer wall of the kettle body 1, and the sealing ring 319 can block the gap between the baffle 316 and the kettle body 1, thereby improving the sealing between the baffle 316 and the kettle body 1. The side of the second arc plate 310 is slidably penetrated with a guide rod 311 for guiding and positioning the second arc plate 310. One end of the guide rod 311 is fixedly connected to the first arc plate 306. When the screw rod 309 drives the second arc surface to move, the guide rod 311 can guide and position the second arc plate 310, thereby avoiding rotational deviation during the movement of the second arc plate 310.

[0087] The effect achieved by the entire regulating device 3 is that, by setting the regulating device 3, the filter plate 301 and the filter holes can filter the precipitate during the preparation process, thereby avoiding the accumulation of the precipitate inside the kettle body 1, and after the filtration is completed, the precipitate on the filter plate 301 can be conveniently processed, making the preparation process more efficient and reducing the downtime caused by blockage.

[0088] like Figure 8 and Fig. 9 As shown, the auxiliary device 4 includes a fixed seat 41, one side of the fixed seat 41 is fixedly connected to the outer wall of the feed pipe 9, the inner wall of the fixed seat 41 is rotatably connected to a connecting plate 42, one side of the connecting plate 42 is fixedly connected to a cover plate 43, the diameter of the cover plate 43 is larger than the diameter of the feed pipe 9, one side of the fixed seat 41 is provided with a sliding hole 44, the center of the sliding hole 44 is coaxial with the axis of rotation of the connecting plate 42, the inner wall of the sliding hole 44 is slidably connected to a sliding rod 45, one end of the sliding rod 45 is fixedly connected to the connecting plate 42, and the arc surface of the sliding rod 45 is threadedly connected to the connecting plate The adjusting ring 46 fixed by 42 can be easily adjusted by the auxiliary device 4 to open and close the feed tube 9 to seal it, thereby improving the convenience of the feeding process and the practicability of the preparation device and preparation method of the whitening and spot-removing composition suitable for sensitive skin. A gasket 47 is fixedly connected to the side of the adjusting ring 46 close to the fixed seat 41. The gasket 47 is made of rubber. The gasket 47 can increase the friction force of the adjusting ring 46 close to the fixed seat 41, thereby achieving the effect of enabling the adjusting ring 46 to be firmly abutted against the fixed seat 41 with the help of the gasket 47.

[0089] The effect achieved by the entire auxiliary device 4 is that, by setting the auxiliary device 4, personnel can conveniently adjust the cover 43 to open and close and seal the feed tube 9, thereby improving the convenience of the feeding process and improving the practicality of the whitening and spot-removing composition preparation equipment and preparation method suitable for sensitive skin.

[0090] A preparation method of a whitening and spot-lightening composition suitable for sensitive skin and a preparation method thereof,

[0091] The components include nicotinamide, tranexamic acid, glabridin, nonapeptide-1, and mango fruit extract. In terms of mass fractions, the following are included:

[0092] Niacinamide: 0.1-10 parts

[0093] Tranexamic acid: 0.1-10 parts

[0094] Glabridin composition: 0.001-2 parts

[0095] Nonapeptide-1 composition: 0.1-10 parts

[0096] Mango fruit extract composition: 0.1-10 parts

[0097] The niacinamide, tranexamic acid, glabridin composition, nonapeptide-1 composition and mango fruit extract composition are mixed in a container, and then stirred and dissolved at 30-40° C. to prepare a whitening and spot-lightening composition.

[0098] S1. The glabridin composition is composed of glabridin / 10% and cyclodextrin / 90%. The nonapeptide-1 composition is composed of water / 10%-40%, glycerol / 60%-90%, nonapeptide-1 / 0.045%-0.06%. The mango fruit extract composition is composed of water / 62.5%-67.5%, glycerol / 25%-30%, and mango (MANGIFERA INDICA) fruit extract / 6.5%-8.5%.

[0099] S2. Preparation method of nicotinamide:

[0100] S21, 3-cyanopyridine is melted and then transferred to a reaction kettle for hydrolysis reaction with a sodium hydroxide solution;

[0101] S22, 3-cyanopyridine is hydrolyzed by sodium hydroxide, filtered through activated carbon, candle filter, etc., and evaporated and concentrated at a temperature of 65°C and a pressure of 580-630 mm Hg;

[0102] S23, then reacting with aqueous ammonia to undergo an ammonolysis reaction;

[0103] S24, the obtained product is sent to the laboratory for quality inspection after crystallization, centrifugation, wet grinding and sieving;

[0104] S25. The product is qualified if the nicotinic acid content is less than 100 ppm by HPLC detection method;

[0105] S3. Preparation method of tranexamic acid:

[0106] S31, heating and dissolving p-carboxybenzylamine in an aqueous sulfuric acid solution;

[0107] S32, using platinum oxide as a catalyst, introducing nitrogen and hydrogen (0.5-1 kg / m2), and adding calcium hydroxide for neutralization after the reaction is completed;

[0108] S33, filtering and concentrating to obtain cis-p-aminomethylcyclohexanecarboxylic acid;

[0109] S34, add calcium hydroxide, increase pressure and temperature for 14 hours, and neutralize with dilute sulfuric acid to pH 5.5-5.6;

[0110] S35, decolorizing with activated carbon, crystallizing with ethanol, and obtaining the target product p-aminomethylcyclohexanecarboxylic acid (trans), which is tranexamic acid;

[0111] S4. Preparation method of glabridin composition:

[0112] S41. Pick the roots of mature Glycyrrhiza glabra and wash them thoroughly;

[0113] S42, crushing by a crusher;

[0114] S43, extraction;

[0115] S44, chromatography;

[0116] S45, vacuum drying after crystallization, and dissolving again;

[0117] S46, encapsulating the active substance with cyclodextrin;

[0118] S47, the obtained product is filtered, concentrated, vacuum dried, crushed, sieved and then sent for quality inspection;

[0119] S48. The product is qualified if the content of glabridin is ≥10% by HPLC detection method;

[0120] S5. Preparation method of nonapeptide-1 composition:

[0121] S51, synthesis;

[0122] S52, purification;

[0123] S53, concentration;

[0124] S54, freeze-dried;

[0125] S55, dissolving the polypeptide substance, adding glycerol, and preparing with sterile deionized water to obtain a solution of corresponding concentration;

[0126] S6. Preparation method of mango fruit extract composition:

[0127] S61, pick the mangoes and wash them thoroughly;

[0128] S62, separating the pulp by a separator;

[0129] S63, adding enzymatic hydrolysis to extract the mango fruit extract;

[0130] S64, performing solid / liquid separation;

[0131] S65. Finally, test for pesticide residues, allergens, and heavy metals.

[0132] 1. The composition ratios of experimental groups 1-3 are as follows:

[0133]

[0134] 2. Irritation test

[0135] Patch testing to test the irritation of cosmetics

[0136] Blank control group: purified water

[0137] Subjects: According to the subject requirements in the 2022 Draft of Cosmetic Safety Technical Specifications, a total of 30 subjects were recruited, including 15 males and 15 females, aged 18-60 years old

[0138] Test method: Using the closed patch test method, the test object is placed in the patch tester and applied to the subject's arm with low-allergenic tape. The test object is removed after 24 hours, and the skin reaction is observed at 0.5, 24, and 48 hours after removal, and the results are recorded in accordance with the skin reaction grading standards in the "2022 Edition of the Draft for Comments on Cosmetic Safety Technical Specifications".

[0139]

[0140] Judgment basis:

[0141] Grade 0 - negative skin reaction;

[0142] Grade 1 - questionable reaction, only slight erythema;

[0143] Grade 2 - weak positive reaction (erythema reaction); erythema, infiltration, edema, and papules may be present;

[0144] Grade 3 - Strong positive reaction (herpes reaction); erythema, infiltration, edema, herpes; the reaction may extend beyond the test area;

[0145] Grade 4 - Very strong positive reaction (confluent herpes reaction); obvious erythema, severe infiltration, edema, confluent herpes; reaction exceeds the tested area.

[0146] Test result explanation: The test results of 30 subjects were all negative.

[0147] Whitening test (human evaluation)

[0148] Testers: 30 qualified subjects were selected according to the inclusion and exclusion criteria, and the final number of effective cases was 30, with an effective rate of 100%.

[0149] Test area: The subject selects the test area on the back where the skin color ITA° value is between 20° and 41°.

[0150] Directions: Use twice a day, morning and evening, for 4 weeks

[0151] Effect index: Determine the change of color brightness (ΔL*), ITA degree, color individual type angle), mainly used as an indicator

[0152] Equation (1): ΔL* = [L* (control or experimental group product after 1 month of testing) - L* (before the test)] - [L* (blank product after 1 month of testing) - L* (before the test)]

[0153] ITA° average value (before): the average value of each group before the experiment (the average value of each group is 28)

[0154] ITA° average (after): average value of each group after one month of experiment

[0155] Meaning of ITA°: Represents the overall change in chromaticity. The larger the ITA° value, the lighter the skin color.

[0156]

[0157] Whitening test effect table of experimental groups 1-3

[0158]

[0159] The test results show that the compositions of the experimental groups 1-3 all have significant effects of "removing spots, reducing or slowing down skin pigmentation, achieving skin whitening and brightening effects, brightening skin tone and improving dullness".

[0160] The overall working principle is as follows: 1. In the present invention, when a reaction kettle is needed to prepare a whitening and freckle-removing composition, the raw materials are first poured into the kettle body 1 along the feed pipe 9 in sequence, and then the servo motor 10 is started to drive the round rod 11 to rotate, and the round rod 11 drives the stirring rod 12 to stir and mix the raw materials inside the kettle body 1, and finally the valve 6 is opened to discharge the mixed raw materials from the discharge pipe. In the preparation process, precipitates will be generated. In order to prevent the precipitates from clogging the discharge pipe, the filter holes on the filter plate 301 can filter the precipitates. When the precipitates on the filter plate 301 need to be processed after the preparation is completed, the motor 307 is first started to drive the screw rod 309 to rotate, and the screw rod 309 drives the second arc plate 310 to move toward the direction close to the round rod 11, so that the second arc plate 310 moves to the direction close to the round rod 11. 0 drives the rubber pad 312 to contact the round rod 11, and then starts the servo motor 10 to drive the round rod 11 to rotate at a low speed. During the rotation of the round rod 11, the sliding plate 304 is driven to slide along the inner wall of the annular rail 303. At the same time, the sliding plate 304 drives the scraper 305 to rotate along the surface of the filter plate 301, so that the sediment on the surface of the filter plate 301 can be pushed into the groove 302. When the sediment on the surface of the filter plate 301 enters the groove 302, the electric push rod 317 is started to drive the baffle 316, so that the baffle 316 drives the scraper ring 320 to move away from the kettle body 1. During the movement of the baffle 316, the scraper ring 320 can be driven, so that the scraper ring 320 scrapes the sediment in the groove 302 along the outlet hole 315. The scraped sediment will fall into the dirt collecting box 321. When the dirt collecting box 321 is needed to transport the sediment so as to facilitate the personnel to carry out the next step of processing the sediment, the pressure rod 324 is first rotated to separate the positioning rod 325, and then the handle 322 is moved to drive the dirt collecting box 321, and the dirt collecting box 321 drives the positioning plate 323 to separate from the positioning rod 325. When the dirt collecting box 321 needs to be installed, the handle 322 is moved to drive the dirt collecting box 321, so that the dirt collecting box 321 drives the positioning plate 323 to be sleeved on the arc surface of the positioning rod 325. When the dirt collecting box 321 is moved to the specified position, the pressure rod 324 is rotated to abut against the positioning rod 325, so that the dirt collecting box 321 can be fixed. When the sediment processing is completed, the electric push rod 317 is started to drive the baffle 316 The outlet hole 315 is blocked, and the sealing ring 319 on the baffle 316 can block the gap between the baffle 316 and the kettle body 1, thereby improving the sealing between the baffle 316 and the kettle body 1. Finally, the operation of the servo motor 10 is started and stopped, and the motor 307 is started to drive the screw rod 309 to rotate in the opposite direction, so that the second arc plate 310 drives the rubber pad 312 to separate from the round rod 11. In the process of the sliding plate 304 driving the scraper 305 to rotate, the connecting frame 313 and the scraper 314 will also be driven to rotate along the inner wall of the kettle body 1, so that the dirt attached to the inner wall of the kettle body 1 can be scraped off. In addition, by setting one end of the positioning rod 325 to a conical structure, the positioning plate 323 can be easily sleeved on the arc surface of the positioning rod 325. Finally,When the screw rod 309 drives the second arc surface to move, the guide rod 311 can guide and position the second arc plate 310, thereby preventing the second arc plate 310 from rotating and deviating during its movement.

[0161] When the material is put into the feed pipe 9, the adjusting ring 46 is first rotated to drive the gasket 47 to separate from the fixing seat 41, and then the connecting plate 42 is rotated to drive the cover plate 43 to separate from the feed pipe 9, so that the cover plate 43 is rotated in the direction away from the feed pipe 9. During the rotation of the cover plate 43, the connecting plate 42 will be driven to rotate along the inner wall of the fixing seat 41. At the same time, the connecting plate 42 will drive the slide bar 45 to slide along the inner wall of the slide hole 44. When the cover plate 43 is opened, the personnel interface puts the material into the feed pipe 9. After the material is put into, the cover plate 43 is rotated again to block the opening of the feed pipe 9. Finally, the adjusting ring 46 is rotated to drive the gasket 47 to abut against the fixing seat 41, so that the cover plate 43 can be fixed, and the feeding operation can be completed. Among them, the gasket 47 can increase the friction force of the adjusting ring 46 close to the fixing seat 41, so that the adjusting ring 46 can be firmly abutted against the fixing seat 41 with the help of the gasket 47.

[0162] The above description is only a preferred embodiment of the present invention and does not limit the present invention in other forms. Any technician familiar with the profession may use the technical content disclosed above to change or modify it into an equivalent embodiment with equivalent changes and apply it to other fields. However, any simple modification, equivalent change and modification made to the above embodiment based on the technical essence of the present invention without departing from the content of the technical solution of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A device for preparing a whitening and spot-lightening composition suitable for sensitive skin, comprising a kettle (1) and a regulating device (3), characterized in that: The lower surface of the kettle body (1) is fixedly connected to a plurality of support columns (2) used to form the kettle body (1); the lower surface of the kettle body (1) is fixedly connected to a discharge pipe (5); the arc surface of the discharge pipe (5) is installed with a valve (6); the arc surface of the kettle body (1) is fixedly connected to a heating pipe (7); the arc surface of the kettle body (1) is fixedly connected to a heat dissipation pipe (8); the upper surface of the kettle body (1) is fixedly connected to a feed pipe (9) for feeding; the upper surface of the kettle body (1) is fixedly connected to a servo motor (10); the output end of the servo motor (10) is fixedly connected to a round rod (11); the arc surface of the round rod (11) is fixedly connected to a stirring rod (12) for stirring; the regulating device (3) is located at The regulating device (3) is used for filtering the precipitate generated during the preparation process. The regulating device (3) comprises a filter plate (301), the filter plate (301) is fixedly connected to the inner wall of the kettle body (1), the filter plate (301) is rotatably connected to the round rod (11), a plurality of filter holes are provided on the surface of the filter plate (301), a groove (302) is provided on the upper surface of the filter plate (301), the cross section of the groove (302) is fan-shaped, the inner wall of the kettle body (1) is fixedly connected to an annular rail (303), the inner wall of the annular rail (303) is slidably connected to a sliding plate (304), the lower surface of the sliding plate (304) is fixedly connected to a filter plate for scraping the precipitate on the filter plate (301) into the groove ( The scraper (305) is provided in the filter plate (302), the lower surface of the scraper (305) is fitted with the upper surface of the filter plate (301), one side of the sliding plate (304) is fixedly connected to a first arc plate (306), the inner wall of the first arc plate (306) is fitted with the arc surface of the round rod (11), one side of the first arc plate (306) is rotatably connected to a screw rod (309), the other side of the first arc plate (306) is fixedly connected to a motor (307) for driving the screw rod (309) to rotate, the output end of the motor (307) is fixedly connected to the screw rod (309), the outer sleeve of the motor (307) is provided with a waterproof cover (308) for waterproofing, one side of the waterproof cover (308) is fixedly connected to the arc plate The arc surface of the screw rod (309) is threadedly connected to a second arc plate (310), the inner wall of the first arc plate (306) is fixedly connected to a rubber pad (312), the outer wall of the kettle body (1) is provided with an outlet hole (315), the inner wall of the outlet hole (315) is fitted with a baffle (316) for sealing the outlet hole (315), the outer wall of the kettle body (1) is fixedly connected to an electric push rod (317) for controlling the movement of the baffle (316), the output end of the electric push rod (317) is fixedly connected to a connecting plate (318), one side of the long arm end of the connecting plate (318) is fixedly connected to the baffle (316), and the side of the baffle (316) away from the connecting plate (318) is fixedly connected to a scraper ring (320),The scraper ring (320) has a fan-shaped cross section, and the lower surface of the scraper ring (320) fits with the bottom of the inner wall of the groove (302); The regulating device (3) further comprises a dirt collecting box (321) for storing sediment, a handle (322) for controlling the dirt collecting box (321) being fixedly connected to one side of the dirt collecting box (321), positioning plates (323) being fixedly connected to both sides of the outer wall of the dirt collecting box (321), a pressure rod (324) being threadedly penetrated through the upper surface of the positioning plate (323), a positioning rod (325) being slidably penetrated through the side surface of the positioning plate (323), and one end of the positioning rod (325) being fixedly connected to the outer wall of the kettle body (1).

2. The preparation device of the whitening and spot-lightening composition suitable for sensitive skin according to claim 1, characterized in that: Both sides of the sliding plate (304) are fixedly connected to a connecting frame (313), one side of the connecting frame (313) is fixedly connected to a scraper (314) for scraping dirt off the inner wall of the kettle body (1), and one side of the scraper (314) is in contact with the inner wall of the kettle body (1).

3. The preparation device of the whitening and spot-lightening composition suitable for sensitive skin according to claim 1, characterized in that: The end of the positioning rod (325) away from the kettle body (1) has a conical structure.

4. The device for preparing the whitening and spot-lightening composition suitable for sensitive skin according to claim 1, characterized in that: A sealing ring (319) is fixedly connected to a side of the baffle plate (316) away from the kettle body (1) for sealing a gap between the baffle plate (316) and the kettle body (1), and one side of the sealing ring (319) is in contact with the outer wall of the kettle body (1).

5. The device for preparing the whitening and spot-lightening composition suitable for sensitive skin according to claim 1, characterized in that: A guide rod (311) is slidably provided on the side surface of the second circular arc plate (310) for guiding and positioning the second circular arc plate (310), and one end of the guide rod (311) is fixedly connected to the first circular arc plate (306).

6. The preparation device of the whitening and spot-lightening composition suitable for sensitive skin according to claim 1, characterized in that: The outer wall of the feed pipe (9) is provided with an auxiliary device (4) for sealing the feed pipe (9), the auxiliary device (4) comprising a fixed seat (41), one side of the fixed seat (41) is fixedly connected to the outer wall of the feed pipe (9), the inner wall of the fixed seat (41) is rotatably connected to a connecting plate (42), one side of the connecting plate (42) is fixedly connected to a cover plate (43), the diameter of the cover plate (43) is larger than the diameter of the feed pipe (9), one side of the fixed seat (41) is provided with a sliding hole (44), the center of the sliding hole (44) is coaxial with the axis of rotation of the connecting plate (42), the inner wall of the sliding hole (44) is slidably connected to a sliding rod (45), one end of the sliding rod (45) is fixedly connected to the connecting plate (42), and the arc surface of the sliding rod (45) is threadedly connected to an adjustment ring (46) for fixing the connecting plate (42).

7. The device for preparing the whitening and spot-lightening composition suitable for sensitive skin according to claim 6, characterized in that: A gasket (47) is fixedly connected to one side of the adjustment ring (46) close to the fixing seat (41), and the gasket (47) is specifically made of rubber material.

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