A hydrogen-rich antioxidant raw material and preparation method thereof, and hydrogen molecule antibacterial dressing

Abstract

The present invention belongs to the technical field of medical dressings, and discloses a hydrogen-rich antioxidant raw material and a preparation method thereof, and a hydrogen molecule antibacterial dressing. The hydrogen molecule antibacterial dressing comprises a medical dressing substrate and a hydrogen-rich antioxidant raw material uniformly dispersed in the pores of the medical dressing substrate. The hydrogen-rich antioxidant raw material is prepared by the following steps: S1. A magnesium-based hydrogen storage powder is prepared by hydrogenating the high-temperature carbonized modified magnesite powder; S2. The magnesium-based hydrogen storage powder is ball-milled, and the ball-milling process is carried out under a hydrogen protective atmosphere, the ball-milling speed is 0.1 to 400 r / min, and the ball-milling time does not exceed 12 hours; S3. After grinding silica, sodium bicarbonate, ascorbic acid and chitosan, they are mixed with the ball-milled magnesium-based hydrogen storage powder, and dried to obtain a mixed powder; S4. The mixed powder, xanthan gum, dioctyl carbonate, hydrogenated lecithin, acrylic acid (acetic acid) copolymer, citric acid, and sodium hyaluronate are stirred and mixed in water to obtain a hydrogen-rich antioxidant raw material.

Description

Technical Field

[0001] The invention belongs to the technical field of medical dressings, and specifically relates to a hydrogen-rich antioxidant raw material and a preparation method thereof, and a hydrogen molecule antibacterial dressing. Background Art

[0002] The skin is a barrier between the human body and the external environment, and can effectively protect various tissues and organs in the body from external physical, mechanical, chemical and pathogenic microorganisms. When the human skin is damaged, if it cannot heal in time, the wound surface needs to be covered with dressings in time for protection.

[0003] At present, with the development of medical plastic surgery and the aggravation of living environment pollution, the skin surface or plastic surgery wounds are eroded by excessive malignant free radicals, which can easily lead to damage and aging of skin barriers such as sebum membrane and stratum corneum. Therefore, how to reduce skin barrier damage and accelerate the repair of damaged skin is an important issue to be solved in the present invention application. Summary of the invention

[0004] In view of this, in order to solve the problems raised in the above background technology, the purpose of the present invention is to provide a hydrogen-rich antioxidant raw material and a preparation method thereof, and a hydrogen molecule antibacterial dressing.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] A method for preparing a hydrogen-rich antioxidant raw material for preparing a hydrogen molecule antibacterial dressing comprises the following steps:

[0007] S1. A magnesium-based hydrogen storage powder is prepared by hydrogenating the high-temperature carbonized modified magnesite powder;

[0008] S2. The magnesium-based hydrogen storage powder is ball-milled, and the ball-milling process is carried out under a hydrogen atmosphere, the ball-milling speed is 0.1 to 400 r / min, and the ball-milling time does not exceed 12 h;

[0009] S3. The silica, sodium bicarbonate, ascorbic acid and chitosan were ground and mixed with the ball-milled magnesium-based hydrogen storage powder and dried to obtain a mixed powder;

[0010] S4. Stir and mix the mixed powder, xanthan gum, dicaprylyl carbonate, hydrogenated lecithin, acrylic copolymer, citric acid, and sodium hyaluronate in water to obtain a hydrogen-rich antioxidant raw material.

[0011] Preferably, the high temperature carbonization modification is to heat the magnesite ore powder at 300-400° C. for 1-1.5 h.

[0012] Preferably, the hydrogenation reaction is as follows: grinding the high-temperature carbonized modified magnesia ore powder to 600-800 mesh, adding deionized water and the ground magnesia ore powder into a closed container, sealing and stirring for 10-12 hours, and continuously filling the deionized water with hydrogen, and after the reaction is completed, filtering the water and drying to obtain magnesium-based hydrogen storage powder.

[0013] Preferably, the drying temperature is 80-85° C. and the drying time is 20-25 min.

[0014] Preferably, the mass mixing ratio of the silica, sodium bicarbonate, ascorbic acid, chitosan and magnesium-based hydrogen storage powder is 4-6:11-13:1:5:7-8.

[0015] Preferably, the mass mixing ratio of the mixed powder, xanthan gum, dicaprylyl carbonate, hydrogenated lecithin, acrylic copolymer, citric acid and sodium hyaluronate is 30:1-3:0.5-1:0.5-1:0.5-1:0.5-1:2-4.

[0016] Preferably, the water accounts for 60% of the total mass of the hydrogen-rich antioxidant raw material.

[0017] Based on the above preparation method, the present invention also provides a hydrogen-rich antioxidant raw material, including water, magnesium-based hydrogen storage powder, silica, sodium bicarbonate, ascorbic acid, chitosan, xanthan gum, dioctyl carbonate, hydrogenated lecithin, acrylic copolymer, citric acid, sodium hyaluronate and other ingredients.

[0018] Magnesium-based hydrogen storage powder: When magnesium-based hydrogen storage powder and silica are mixed and contacted with water, hydrogen gas is generated. The water containing hydrogen molecules constitutes functional water with antioxidant effect.

[0019] Chitosan: It is safe and non-toxic, has hemostatic, antibacterial and antifungal effects;

[0020] Xanthan gum: provides stability and thickening function;

[0021] Dicaprylyl carbonate, hydrogenated lecithin, acrylic acid copolymer: have moisturizing and emulsifying functions;

[0022] Citric acid: adjusts the acidity and alkalinity of hydrogen-rich antioxidant raw materials;

[0023] Sodium Hyaluronate: Lubricates and nourishes the skin.

[0024] As a general inventive concept, the present invention also provides a hydrogen molecule antibacterial dressing:

[0025] The hydrogen molecule antibacterial dressing comprises a medical dressing substrate and a hydrogen-rich antioxidant raw material, and the hydrogen-rich antioxidant raw material is prepared by the preparation method provided above.

[0026] Preferably, the medical dressing substrate is made of nano-antibacterial fibers electrostatically spun, and the pore size of the medical dressing substrate is 0.2-15 μm, the porosity is 20-45%, and the diameter of the nano-antibacterial fibers is 100-500 nm.

[0027] Preferably, the medical dressing substrate is immersed in the hydrogen-rich antioxidant raw material so that the hydrogen-rich antioxidant raw material uniformly fills the pores of the medical dressing substrate to obtain a hydrogen molecule antibacterial dressing.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] (1) The magnesite powder is modified by high-temperature carbonization to have a rich porous structure. Then, a high amount of hydrogen storage is formed in the magnesite powder based on a hydrogenation reaction, and the hydrogen molecules are applied to a water-containing mixed liquid material, so that the liquid material constitutes functional water with antioxidant ability, thereby reducing the erosion of the skin surface and wounds by malicious free radicals and accelerating wound healing.

[0030] (2) Chitosan is a deacetylated derivative of chitin, which is safe, non-toxic, hemostatic, antibacterial and antifungal. Therefore, the hydrogen-rich antioxidant raw material of the present invention has the functions of antioxidant, antibacterial, anti-inflammatory, and accelerated wound healing.

[0031] (3) A hydrogen molecule antibacterial dressing is prepared by using a medical dressing substrate made of electrostatically spun nano-antibacterial fibers and infiltrating hydrogen-rich antioxidant raw materials. When applied to wounds on the skin surface, it can effectively kill bacteria and inflammation, resist oxidation, and accelerate wound healing. DETAILED DESCRIPTION

[0032] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention. Example

[0033] A hydrogen-rich antioxidant raw material, comprising the following components in percentage by mass:

[0034] Main ingredients (90%)

[0035] Water 60%; Magnesium-based hydrogen storage powder 7%; Silica 5% Sodium bicarbonate 12%; Ascorbic acid (vitamin C) 1%; Chitosan 5%;

[0036] Excipients (10%)

[0037] Xanthan gum 3%, dicaprylyl carbonate 1%, hydrogenated lecithin 1%, acrylic acid copolymer 1%, citric acid 1%, sodium hyaluronate 3%;

[0038] The sum of the mass percentages of the entire components is 100%.

[0039] Regarding the hydrogen-rich antioxidant raw material provided in this embodiment, on the one hand, it can be used to prepare hydrogen molecule antibacterial dressings, and on the other hand, it can also be directly applied to the skin surface as a functional liquid material, wherein the magnesium-based hydrogen storage powder plays an antioxidant role by releasing hydrogen molecules, and chitosan plays an antibacterial role, thereby enabling the hydrogen-rich antioxidant raw material of this embodiment to directly constitute a skin care liquid with anti-inflammatory, antibacterial, antioxidant and other functions. Example

[0040] A method for preparing an antioxidant raw material for preparing a hydrogen-rich molecular antibacterial dressing:

[0041] S1. A magnesium-based hydrogen storage powder is prepared by hydrogenating the high-temperature carbonized modified magnesite powder; wherein:

[0042] The high temperature carbonization modification is to heat the magnesite powder at 300-400° C. for 1-1.5 h;

[0043] The hydrogenation reaction is as follows: grinding the high-temperature carbonized modified magnesite powder to 600-800 meshes, adding deionized water and the ground magnesite powder into a sealed container (the deionized water covers the magnesite powder), sealing and stirring for 10-12 hours, and continuously filling the deionized water with hydrogen, and after the reaction is completed, filtering the water and drying to obtain the magnesium-based hydrogen storage powder.

[0044] S2. Weigh the raw materials according to the composition ratio provided in Example 1 above;

[0045] S3. The magnesium-based hydrogen storage powder is ball-milled, and the ball-milling process is carried out under a hydrogen atmosphere, the ball-milling speed is 0.1 to 400 r / min, and the ball-milling time does not exceed 12 h;

[0046] S4. The silica, sodium bicarbonate, ascorbic acid and chitosan were ground and mixed with the ball-milled magnesium-based hydrogen storage powder according to the proportion, and dried at a temperature of 80 to 85 ° C for 20 to 25 min to obtain a mixed powder;

[0047] S5. Stir and mix the mixed powder, xanthan gum, dicaprylyl carbonate, hydrogenated lecithin, acrylic copolymer, citric acid, and sodium hyaluronate in water in proportion to obtain a hydrogen-rich antioxidant raw material.

[0048] Comparative Example

[0049] S1. Pour deionized water and 50-300 mesh magnesite powder (deionized water covers the magnesite powder) into a sealed container, seal and stir for 10-12 hours, and continue to add hydrogen to the deionized water. After the reaction is completed, filter the water and dry to obtain magnesium-based hydrogen storage powder. (No high-temperature carbonization modification treatment)

[0050] S2 to S5 are the same as in Example 2 above to obtain comparative raw materials.

[0051] (1) Testing the water-soluble hydrogen concentration of the above hydrogen-rich antioxidant raw materials and the comparative raw materials:

[0052] The magnesium-based hydrogen storage powders prepared in Example 2 and the comparative example were weighed respectively and placed in 300 mL of pure water. A KH888 dissolved hydrogen / negative potential test pen was inserted into the water for detection, and the detection results shown in the following table were obtained.

[0053]

[0054] (2) Physical and chemical data testing of the above hydrogen-rich antioxidant raw materials:

[0055] According to the above test results, the hydrogen-rich antioxidant raw materials provided in Example 1 and Example 2 can effectively increase the hydrogen storage capacity in the magnesite ore powder by subjecting the magnesite ore powder to high-temperature carbonization modification treatment, thereby effectively improving the antioxidant effect of the prepared hydrogen-rich antioxidant raw materials. The specific antioxidant principle is: hydrogen molecules, as the smallest known molecules, can deeply penetrate into the basal layer of the skin during contact with the skin, providing deep care for the skin. At the same time, hydrogen molecules also have the characteristics of scavenging malignant free radicals, thereby achieving the effects of repairing damaged skin and anti-oxidation. In addition, the overall preparation method has simple steps, is efficient and fast, and has low cost, and is suitable for industrial production. Example

[0056] A hydrogen molecule antibacterial dressing comprises a medical dressing substrate and a hydrogen-rich antioxidant raw material.

[0057] The medical dressing substrate is formed by electrostatic spinning of nano antibacterial fibers, and the pore size of the medical dressing substrate is 0.2-15 μm, the porosity is 20-45%, and the diameter of the nano antibacterial fibers is 100-500 nm.

[0058] The hydrogen-rich antioxidant raw material is the hydrogen-rich antioxidant raw material provided in the above-mentioned Example 1 or the hydrogen-rich antioxidant raw material prepared in Example 2.

[0059] The hydrogen molecule antibacterial dressing provided in this embodiment is mainly used for medical treatment of skin wound injuries. Of course, it can also be used as a daily skin care mask to achieve skin care effects such as moisturizing, hydrating, and anti-oxidation. Example

[0060] A preparation method of hydrogen molecule antibacterial dressing:

[0061] The medical dressing substrate is immersed in the hydrogen-rich antioxidant raw material, so that the hydrogen-rich antioxidant raw material uniformly fills the pores of the medical dressing substrate to obtain a hydrogen molecule antibacterial dressing.

[0062] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A method for preparing a hydrogen-rich antioxidant raw material for preparing a hydrogen molecule antibacterial dressing, characterized in that: The steps include: S1. A magnesium-based hydrogen storage powder is prepared by hydrogenating the high-temperature carbonized modified magnesite powder; S2. The magnesium-based hydrogen storage powder is ball-milled, and the ball-milling process is carried out under a hydrogen atmosphere, the ball-milling speed is 0.1 to 400 r / min, and the ball-milling time does not exceed 12 h; S3. The silica, sodium bicarbonate, ascorbic acid and chitosan were ground and mixed with the ball-milled magnesium-based hydrogen storage powder and dried to obtain a mixed powder; S4. The mixed powder and xanthan gum, dicaprylyl carbonate, hydrogenated lecithin, acrylic copolymer, citric acid, and sodium hyaluronate are stirred and mixed in water to obtain a hydrogen-rich antioxidant raw material; The high temperature carbonization modification is to heat the magnesite powder at 300-400° C. for 1-1.5 h; The hydrogenation reaction is as follows: grinding the high-temperature carbonized modified magnesia ore powder to 600-800 meshes, adding deionized water and the ground magnesia ore powder into a sealed container, sealing and stirring for 10-12 hours, and continuously filling the deionized water with hydrogen, filtering and drying after the reaction is completed to obtain magnesium-based hydrogen storage powder; The mass mixing ratio of the silica, sodium bicarbonate, ascorbic acid, chitosan and magnesium-based hydrogen storage powder is 4-6:11-13:1:5:7-8.

2. The method for preparing a hydrogen-rich antioxidant raw material for preparing a hydrogen molecule antibacterial dressing according to claim 1, characterized in that: The drying temperature is 80-85° C. and the drying time is 20-25 min.

3. The method for preparing a hydrogen-rich antioxidant raw material for preparing a hydrogen molecule antibacterial dressing according to claim 1, characterized in that: The mass mixing ratio of the mixed powder, xanthan gum, dicaprylyl carbonate, hydrogenated lecithin, acrylic copolymer, citric acid and sodium hyaluronate is 30:1-3:0.5-1:0.5-1:0.5-1:0.5-1:2-4.

4. The method for preparing a hydrogen-rich antioxidant raw material for preparing a hydrogen molecule antibacterial dressing according to claim 3, characterized in that: The water accounts for 60% of the total mass of the hydrogen-rich antioxidant raw material.

5. A hydrogen-rich antioxidant raw material prepared by the preparation method according to any one of claims 1 to 4.

6. A hydrogen molecule antibacterial dressing, characterized in that: The hydrogen molecule antibacterial dressing comprises a medical dressing substrate and a hydrogen-rich antioxidant raw material, and the hydrogen-rich antioxidant raw material is the hydrogen-rich antioxidant raw material as described in claim 5; the medical dressing substrate is electrostatically spun from nano antibacterial fibers, and the pore size of the medical dressing substrate is 0.2 to 15 μm, the porosity is 20 to 45%, and the diameter of the nano antibacterial fibers is 100 to 500 nm.

7. The hydrogen molecule antibacterial dressing according to claim 6, characterized in that: The medical dressing substrate is immersed in the hydrogen-rich antioxidant raw material, so that the hydrogen-rich antioxidant raw material uniformly fills the pores of the medical dressing substrate to obtain a hydrogen molecule antibacterial dressing.

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