Preparation method of tortoise shell glue powder

Abstract

The invention discloses a preparation method of tortoise-shell glue powder, tortoise-shell glue is used as a nourishing product with functions of nourishing yin, nourishing blood and stopping bleeding, due to complexity in production and limitation in use, the preparation method of the tortoise-shell glue powder is invented, the tortoise-shell glue is dried in vacuum, and the prepared tortoise-shell glue is loose, porous and spongy after being dried, and is crushed, so that the tortoise-shell glue powder is obtained. Screening treatment is conducted, and the required standard requirements of tortoise shell glue powder are met; and meanwhile, the vacuum drying saves the drying time, reduces the risk caused by an overlong production process, and conforms to the principle of safety, effectiveness and accessibility of medicine production.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine production, and is a method for preparing a glue product, in particular to a method for preparing tortoise shell glue powder. Background Art

[0002] Tortoise shell glue is from the family Testudinidae Chinemys reevesii The solid glue made from the carapace and plastron of the turtle (Gray) through boiling and concentrating in water has the functions of nourishing yin, nourishing blood and stopping bleeding; it is used for yin deficiency hot flashes, bone steaming and night sweats, soreness of waist and knees, blood deficiency and sallow complexion, metrorrhagia and leukorrhea, etc.; "Shennong's Materia Medica" records that the turtle shell is also called Shenwu; it grows in ponds and ze; it tastes salty and flat; it is mainly used to treat red and white leakage, breaking up tumors, malaria, five types of hemorrhoids, yin erosion, dampness and arthritis, heaviness and weakness of limbs, and malformation of children's fontanelles; long-term consumption makes the body lighter and not hungry; Li Shizhen's "Compendium of Materia Medica" records that the turtle is spiritual and long-lived, and the turtle head is often hidden in the abdomen , which can open the Ren meridian, so its shell is taken to nourish the heart, kidney and blood, and to nourish Yin; tortoise shell glue is now mostly used for male and female infertility, menopausal syndrome, people with kidney yin deficiency, kidney yang deficiency or yin and yang deficiency, the elderly and children with physical weakness, lack of energy, soreness of waist and legs, etc., people with kidney deficiency syndrome, chronic nephritis, lupus nephritis, chronic pyelonephritis, low back pain, proteinuria, etc., people with yin deficiency and hot flashes, low fever caused by functional low fever, pulmonary tuberculosis, bone tuberculosis, etc., after tumor surgery, people with physical weakness, etc.

[0003] Turtle shell glue is a Chinese patent medicine glue, and is also one of the commonly used Chinese medicine slices. It is listed in the "Chinese Pharmacopoeia" of all editions. However, since turtle shell is the shell of an animal, it is limited in use. For example, it is difficult to decoct the effective ingredients, and it takes a long time to decoct them alone. If they are decocted together, the effective ingredients will not be completely decocted, resulting in waste and affecting the effect of the medicine. Therefore, doctors often prescribe turtle shell glue, which is melted and taken during the adjustment. At the same time, turtle shell glue is also used alone. The preparation method is mostly to crush it and then melt it for taking. During the crushing operation, different people have different operation methods and utensils, and there is a risk of pollution. There is no specific standard for the degree of crushing. In addition, the powder of the glue is too fine and easy to stick together during storage. The fine powder is easy to become mushy when melted, which affects the further dissolution effect.

[0004] The current preparation process of tortoise shell glue: the tortoise shell is washed and extracted with water three times. The extract is filtered and combined and concentrated. It is concentrated to "hanging beads". Rock sugar (or other auxiliary materials of sugar-free products) dissolved in water is added and the concentration is continued. The soybean oil is filtered and added and the concentration is continued. The glue is heated to make it boil slightly. When large bubbles appear at the bottom of the pot (the pot is boiling), the rice wine is filtered while stirring and added to the concentrated glue. The glue is continued to be concentrated until the glue is in the form of sheets when picked up with a spatula without falling, commonly known as "hanging shovel". The heating is stopped and the material is released. Then gelation, glue cutting, glue drying, glue collection and packaging are carried out to complete the manufacturing process of tortoise shell glue. The gelation here refers to the tortoise shell glue being concentrated and put into a container, cooled at low temperature into a solid state, which is convenient for cutting into blocks and placing on a drying bed to dry naturally. At this time, the moisture content of the tortoise shell glue is about 20%. In order to make the shape of the dried film good-looking and the moisture content uniform, the temperature and humidity of the drying environment should be controlled in sections during the drying of the glue, and the glue should be turned over and suffocated frequently.

[0005] In view of the limitations of the use of the above-mentioned tortoise shell glue and the complexity of drying the glue in the production operation, the present invention "dries, crushes, and sieves" the tortoise shell glue to make tortoise shell glue powder, specifically: the tortoise shell is extracted with water, the extract is concentrated and foamed, auxiliary materials are added, and the concentration is continued to the "hanging shovel" state to produce glue, and then it is transferred to vacuum drying. When the moisture is dried to less than 10%, it is taken out, crushed, sieved, and packaged to complete the preparation process of tortoise shell glue powder.

[0006] Vacuum drying is the key to the preparation process of tortoise shell glue powder. The tortoise shell glue is sliced ​​after gelling or directly placed in a drying tray and heated in a vacuum state. Due to heating and vacuuming, the boiling point of the tortoise shell glue is reduced and the boiling drying state is maintained, that is, the temperature and vacuum degree are adjusted to make the tortoise shell glue foaming state. When the dry moisture content is below 10%, the heating is stopped and the vacuum state remains unchanged. When the temperature of the tortoise shell glue reaches room temperature, it will become solid, the vacuum is stopped, and it can be taken out, crushed, sieved, and packaged to complete the preparation process of tortoise shell glue powder.

[0007] The tortoise shell glue produced by the above method is loose and porous after drying, and is in the form of a sponge. After being crushed, all of it passes through a No. 1 sieve (average inner diameter of the sieve hole is 2000μm±70μm), and a No. 4 sieve (average inner diameter of the sieve hole is 250μm±9.9μm) to remove the powder, reaching the particle size standard of the "Chinese Pharmacopoeia". It dissolves quickly after adding water and almost immediately restores its original properties. Therefore, whether it is used alone or in combination, it is easy to "melt and take". This facilitates the effect of melting into decoctions.

[0008] After many batches of experimental production of tortoise shell glue powder, the products produced have undergone stability tests and accelerated stability tests, and all indicators meet the current Chinese Pharmacopoeia standards, and the production method is highly operational; at the same time, due to vacuum drying, the production cycle of each batch of products is shortened to 1 / 3 of the original production time, saving production costs and reducing the risk of contamination due to long drying time. Natural drying of glue is greatly affected by the environment, and the natural overflow of moisture generally reaches 12%. It takes a longer time to reach below 10%. Therefore, the invention of the method for preparing tortoise shell glue powder is more convenient for clinical use and production, and the product safety and effectiveness are not affected, which complies with the principles of safety, effectiveness and accessibility of drugs. Summary of the invention

[0009] Tortoise shell glue is from the family Testudinidae Chinemys reevesii The solid glue made from the carapace and plastron of the turtle (Gray) through boiling and concentrating in water has the functions of nourishing yin, nourishing blood and stopping bleeding; it is used for yin deficiency hot flashes, bone steaming and night sweats, soreness of waist and knees, blood deficiency and sallow complexion, metrorrhagia and leukorrhea, etc.; "Shennong's Materia Medica" records that the turtle shell is also called Shenwu; it grows in ponds and ze; it tastes salty and flat; it is mainly used to treat red and white leakage, breaking up tumors, malaria, five types of hemorrhoids, yin erosion, dampness and arthritis, heaviness and weakness of limbs, and malformation of children's fontanelles; long-term consumption makes the body lighter and not hungry; Li Shizhen's "Compendium of Materia Medica" records that the turtle is spiritual and long-lived, and the turtle head is often hidden in the abdomen , which can open the Ren meridian, so its shell is taken to nourish the heart, kidney and blood, and to nourish Yin; tortoise shell glue is now mostly used for male and female infertility, menopausal syndrome, people with kidney yin deficiency, kidney yang deficiency or yin and yang deficiency, the elderly and children with physical weakness, lack of energy, soreness of waist and legs, etc., people with kidney deficiency syndrome, chronic nephritis, lupus nephritis, chronic pyelonephritis, low back pain, proteinuria, etc., people with yin deficiency and hot flashes, low fever caused by functional low fever, pulmonary tuberculosis, bone tuberculosis, etc., after tumor surgery, people with physical weakness, etc.

[0010] Turtle shell glue is a Chinese patent medicine glue, and is also one of the commonly used Chinese medicine slices. It is listed in the "Chinese Pharmacopoeia" of all editions. However, since turtle shell is the shell of an animal, it is limited in use. For example, it is difficult to decoct the effective ingredients, and it takes a long time to decoct them alone. If they are decocted together, the effective ingredients will not be completely decocted, resulting in waste and affecting the effect of the medicine. Therefore, doctors often prescribe turtle shell glue, which is melted and taken during the adjustment. At the same time, turtle shell glue is also used alone. The preparation method is mostly to crush it and then melt it for taking. During the crushing operation, different people have different operation methods and utensils, and there is a risk of pollution. There is no specific standard for the degree of crushing. In addition, the powder of the glue is too fine and easy to stick together during storage. The fine powder is easy to become mushy when melted, which affects the further dissolution effect.

[0011] The current preparation process of tortoise shell glue: the tortoise shell is washed and extracted with water three times. The extract is filtered and combined and concentrated. It is concentrated to "hanging beads". Rock sugar (or other auxiliary materials of sugar-free products) dissolved in water is added and the concentration is continued. The soybean oil is filtered and added and the concentration is continued. The glue is heated to make it boil slightly. When large bubbles appear at the bottom of the pot (the pot is boiling), the rice wine is filtered while stirring and added to the concentrated glue. The glue is continued to be concentrated until the glue is in the form of sheets when picked up with a spatula without falling, commonly known as "hanging shovel". The heating is stopped and the material is released. Then gelation, glue cutting, glue drying, glue collection and packaging are carried out to complete the manufacturing process of tortoise shell glue. The gelation here refers to the tortoise shell glue being concentrated and put into a container, cooled at low temperature into a solid state, which is convenient for cutting into blocks and placing on a drying bed to dry naturally. At this time, the moisture content of the tortoise shell glue is about 20%. In order to make the shape of the dried film good-looking and the moisture content uniform, the temperature and humidity of the drying environment should be controlled in sections during the drying of the glue, and the glue should be turned over and suffocated frequently.

[0012] In view of the limitations of the use of the above-mentioned tortoise shell glue and the complexity of drying the glue in the production operation, the present invention "dries, crushes, and sieves" the tortoise shell glue to make tortoise shell glue powder, specifically: the tortoise shell is extracted with water, the extract is concentrated and foamed, auxiliary materials are added, and the concentration is continued to the "hanging shovel" state to produce glue, and then it is transferred to vacuum drying. When the moisture is dried to less than 10%, it is taken out, crushed, sieved, and packaged to complete the preparation process of tortoise shell glue powder.

[0013] Vacuum drying is the key to the preparation process of tortoise shell glue powder. The tortoise shell glue is sliced ​​after gelling or directly placed in a drying tray and heated in a vacuum state. Due to heating and vacuuming, the boiling point of the tortoise shell glue is reduced and the boiling drying state is maintained, that is, the temperature and vacuum degree are adjusted to make the tortoise shell glue foaming state. When the dry moisture content is below 10%, the heating is stopped and the vacuum state remains unchanged. When the temperature of the tortoise shell glue reaches room temperature, it will become solid, the vacuum is stopped, and it can be taken out, crushed, sieved, and packaged to complete the preparation process of tortoise shell glue powder.

[0014] The tortoise shell glue produced by the above method is loose and porous after drying, and is in the form of a sponge. After being crushed, all of it passes through a No. 1 sieve (average inner diameter of the sieve hole is 2000μm±70μm), and a No. 4 sieve (average inner diameter of the sieve hole is 250μm±9.9μm) to remove the powder, reaching the particle size standard of the "Chinese Pharmacopoeia". It dissolves quickly after adding water and almost immediately restores its original properties. Therefore, whether it is used alone or in combination, it is easy to "melt and take". This facilitates the effect of melting into decoctions.

[0015] After many batches of experimental production of tortoise shell glue powder, the products produced have undergone stability tests and accelerated stability tests, and all indicators meet the current Chinese Pharmacopoeia standards, and the production method is highly operational; at the same time, due to vacuum drying, the production cycle of each batch of products is shortened to 1 / 3 of the original production time, saving production costs and reducing the risk of contamination due to long drying time. Natural drying of glue is greatly affected by the environment, and the natural overflow of moisture generally reaches 12%. It takes a longer time to reach below 10%. Therefore, the invention of the method for preparing tortoise shell glue powder is more convenient for clinical use and production, and the product safety and effectiveness are not affected, which complies with the principles of safety, effectiveness and accessibility of drugs.

Claims

1. A method for preparing tortoise shell glue powder, characterized in that: The tortoise shell is extracted with water, the extract is concentrated and foamed, auxiliary materials are added, and the concentration is continued to the "hanging shovel" state to produce glue, and then it is transferred to vacuum drying. When the moisture content is dried to less than 10%, it is taken out, crushed, sieved, and packaged to complete the preparation process of tortoise shell glue powder.

2. The method for preparing tortoise shell glue powder according to claim 1, characterized in that: Tortoise CMnemys (Gray) carapace and plastron.

3. The method for preparing tortoise shell glue powder according to claim 1, characterized in that: After the tortoise shell glue is produced by vacuum drying, it is placed in a drying tray and carried out under vacuum heating. The drying temperature and vacuum degree are adjusted to make the tortoise shell glue foaming. When the drying moisture content is below 10%, the heating is stopped and the vacuum state remains unchanged. When the temperature of the tortoise shell glue reaches room temperature, the vacuum is stopped and it can be taken out, crushed, sieved, and packaged to complete the preparation process of tortoise shell glue powder.