Preparation process of astragalus polysaccharide powder

Abstract

The invention discloses a preparation technology of astragalus polysaccharide powder, and belongs to the technical field of astragalus polysaccharide powder preparation, and the preparation technology comprises the following steps: step 1, weighing; step 2, decocting; step 3, concentration; step 4, alcohol precipitation; step 5, adding a slow-release agent; step 6, spray drying; step 7, mixing; step 8, inner packaging; step 9, outer packaging; according to the process, the astragalus membranaceus is decocted by adopting a multifunctional extraction tank, and the extraction efficiency is improved by accurately controlling the decoction temperature, time and water volume; in the alcohol precipitation step, ethyl alcohol is gradually added, and standing precipitation is performed, so that impurities in an extracting solution are effectively removed; finally, the concentrated solution is dried into powder through a spray drying technology, the purity of the astragalus polysaccharide is further improved, the astragalus polysaccharide is convenient to store and use, in addition, the technology further pays attention to environmental protection and energy conservation, and in the extraction and purification process, energy consumption is reduced by reasonably adjusting parameters such as the vacuum degree and the temperature.

Description

Technical Field

[0001] The invention belongs to the technical field of astragalus polysaccharide powder preparation, and in particular relates to a preparation process of astragalus polysaccharide powder. Background Art

[0002] Astragalus, as a traditional Chinese medicinal material, has a wide range of application value in the field of traditional Chinese medicine. It is sweet and warm in nature, and enters the spleen and lung meridians. It has the effects of replenishing qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, promoting fluid and nourishing blood, relieving stagnation and relieving arthritis, expelling toxins and draining pus, and healing sores and promoting tissue regeneration. In recent years, with the development of modern science and technology, the active ingredient in Astragalus - Astragalus polysaccharide has gradually attracted attention. Astragalus polysaccharide has significant immunomodulatory, antioxidant, antiviral and other biological activities, and shows broad application prospects in the fields of medicine, health products and veterinary clinics.

[0003] However, traditional astragalus polysaccharide extraction processes often have problems such as low extraction efficiency, difficulty in purification, and high energy consumption. In order to improve the extraction efficiency and purity of astragalus polysaccharides while reducing production costs and environmental pollution, it is urgent to develop an efficient and environmentally friendly astragalus polysaccharide extraction process. Summary of the invention

[0004] The purpose of the present invention is to provide a preparation process of astragalus polysaccharide powder, which is used to solve the technical problems of low extraction efficiency, great purification difficulty and high energy consumption in the traditional astragalus polysaccharide extraction process in the prior art.

[0005] In order to achieve the above object, the present invention adopts the following technical solutions:

[0006] A preparation process of astragalus polysaccharide powder comprises the following steps:

[0007] Step 1, weighing: calibrate the electronic scale before operation, confirm that the electronic scale is within the calibration validity period, and check whether the medicinal material name and quantity information are consistent with the production prescription; among them, check and verify the Astragalus slices, including the name, batch number, quantity, manufacturer, qualified status, and the sample weight is consistent with the batch production instruction;

[0008] Step 2, decoction: put the weighed astragalus into a multifunctional extraction tank, add 0.5-2wt% CaO aqueous solution to submerge the medicinal material and soak for 1-2 hours, then add 6-8 times of water, decoct for 3-5 times, decoction temperature is 90-105°C, each decoction time is 90-120min, the filtrate is filtered and then put into the extract storage tank, then the filter residue is discharged, and the multifunctional extraction tank is cleaned for standby use;

[0009] Step 3, concentration: Concentrate through the extract storage tank, open the heater steam valve, maintain the vacuum degree, and stop concentrating when the material-liquid ratio is 1:1, close the steam valve, close the vacuum valve and empty it, and pump the concentrated material into the alcohol precipitation tank; the concentration vacuum degree is -0.04~-0.06MPa; the concentration temperature is 70-80℃;

[0010] Step 4, alcohol precipitation: After the concentrate is pumped into the alcohol precipitation tank, start stirring and slowly add 90-95vt% ethanol to the alcohol precipitation tank until the alcohol content is 60%, turn off stirring, let it stand for 3-4 hours, filter, and then put the precipitate into the alcohol precipitation tank, turn on stirring, and slowly add 90-95vt% ethanol to the alcohol precipitation tank again until the alcohol content is 80%, turn off stirring, let it stand for 3-4 hours, filter and take the precipitate, put it into the multi-functional extraction tank and dissolve it in water;

[0011] Step 5, adding sustained-release agent: adding sodium hydroxypropyl cellulose and povidone K30 into the multifunctional extraction tank, heating to 60°C, stirring and dissolving, and then pumping into the liquid storage tank for spray drying;

[0012] Step 6, spray drying: when the air inlet temperature is stable at 160-170°C, start the feed pump, receive the material in the powder collecting room, weigh it, and seal it for storage;

[0013] Step 7, mixing: transfer from the temporary storage room of raw materials to the unpacking room for unpacking, weighing, feeding, closing the feed cover of the silo after feeding, setting the mixing time to 40-50 minutes, and after mixing, put it in a clean and dry barrel, cover the barrel cover, and deliver it to the semi-finished product intermediate station, and test it according to the semi-finished product inspection standard of astragalus polysaccharide powder, and flow into the next process after passing the test;

[0014] Step 8, inner packaging: Pick up the semi-finished product of astragalus extract in the stainless steel barrel at the intermediate station, put it into the cleaned packaging machine, put the packaged product bags into the sealing machine for sealing, and then transfer the packaged astragalus polysaccharide powder to the outer packaging room;

[0015] Step 9, Outsourcing: Before packaging, collect and check whether the specifications and quantity of the packaging materials and the products to be packaged are consistent with the packaging instruction sheet, check whether the batch number and label are consistent with the packaging instruction sheet, and package after they are accurate.

[0016] Preferably, the multifunctional extraction tank comprises: a multifunctional cylinder; a heating cylinder fixedly mounted on the multifunctional cylinder; a stirring mechanism installed on the multifunctional cylinder for stirring the material in the multifunctional cylinder; a cleaning mechanism installed in the multifunctional cylinder for cleaning the inner wall of the multifunctional cylinder; a connecting mechanism for connecting the stirring mechanism and the cleaning mechanism; an anti-pressure mechanism, the cover of which is mounted on the connecting mechanism; wherein, when the connecting mechanism is connected to the stirring mechanism and the cleaning mechanism, when the stirring mechanism is in operation, the cleaning mechanism will rotate under the influence of the connecting mechanism and clean the multifunctional cylinder.

[0017] Preferably, the multifunctional extraction tank also includes: a fixing ring installed on the inner wall of the multifunctional cylinder; a feed hopper installed on the top surface of the multifunctional cylinder; a sealing cover hinged to the feed hopper; a drain pipe installed at the bottom of the multifunctional cylinder; a second valve installed on the drain pipe; and a gas valve installed on the multifunctional cylinder.

[0018] Preferably, the stirring mechanism includes: a fixed gear ring installed on the inner top surface of the multifunctional cylinder; a motor installed on the top surface of the multifunctional cylinder; an outer gear ring located inside the multifunctional cylinder and fixedly connected to the lower end of the power output shaft of the motor; two vertical rods, both rotatably connected to the outer gear ring; a plurality of stirring rods, respectively installed on the two vertical rods; two first gears, respectively installed on the upper ends of the two vertical rods, both meshingly connected to the fixed gear ring.

[0019] Preferably, the cleaning mechanism includes: an inner gear ring, located in the multi-functional cylinder and having the same height as the outer gear ring; a slide groove, opened on the outer side surface of the inner gear ring and slidably connected to the fixed ring; and two scraping rods, both installed on the bottom surface of the inner gear ring and in contact with the inner wall of the multi-functional cylinder.

[0020] Preferably, the connecting mechanism includes: a sliding rod, which passes through the top surface of the multi-functional cylinder and is slidably connected to the multi-functional cylinder; a second gear, which is installed at the lower end of the sliding rod and matches the inner gear ring and the outer gear ring; a pressure plate, which is installed at the upper end of the sliding rod; a spring, whose two ends are respectively connected to the bottom surface of the pressure plate and the top surface of the multi-functional cylinder; and a limit ring, which is installed on the top surface of the multi-functional cylinder.

[0021] Preferably, the multifunctional extraction tank further comprises: a discharge pipe installed on the bottom surface of the multifunctional barrel; a first valve installed on the discharge pipe; a threaded barrel installed on the bottom surface of the multifunctional barrel, and the discharge pipe is located inside the threaded barrel.

[0022] Preferably, the anti-pressure mechanism includes: a fixed cylinder, whose bottom is an opening, the inner diameter of the opening of the fixed cylinder is larger than the outer diameter of the limiting ring, the opening of the fixed cylinder can be threadedly connected to the threaded cylinder, and a plurality of filter holes are provided on the top of the fixed cylinder; a groove is provided on the top surface of the fixed cylinder and is plugged into and cooperated with the pressure plate; and two handles are both installed on the sides of the fixed cylinder.

[0023] In summary, due to the adoption of the above technical solution, the beneficial effects of the present invention are:

[0024] 1. The preparation process of the astragalus polysaccharide powder in the present invention is through weighing, decoction, concentration, alcohol precipitation, adding sustained-release agent, spray drying, mixing and other steps. The preparation of astragalus polysaccharide powder can reduce the feeding times of large animals and reduce the stress response of raised animals because it contains sustained-release excipients. The preparation of astragalus polysaccharide powder prepared by this process has the effects of invigorating qi and strengthening the body's resistance, and can be used for the preventive treatment of infectious bursal disease in chickens in veterinary clinics. This process uses a multifunctional extraction tank to decoct astragalus, and improves the extraction efficiency by accurately controlling the decoction temperature, time and water volume; in the alcohol precipitation step, by gradually adding ethanol and standing to precipitate, impurities in the extract are effectively removed; finally, the concentrate is dried into powder by spray drying technology, which further improves the purity of astragalus polysaccharide and is convenient for storage and use. In addition, this process also pays attention to environmental protection and energy saving. In the extraction and purification process, energy consumption is reduced by reasonably adjusting parameters such as vacuum degree and temperature.

[0025] 2. The multifunctional extraction tank of the present invention integrates multiple functions such as heating, stirring, cleaning, filtering, etc. by arranging a multifunctional cylinder, a heating cylinder, a stirring mechanism, a cleaning mechanism, a connecting mechanism and an anti-pressure mechanism, thereby reducing equipment cost and maintenance difficulty.

[0026] 3. The anti-pressure mechanism in the present invention is provided with a fixed cylinder, a groove and a handle. Under normal circumstances, the fixed cylinder cover is arranged on the pressure plate, which can avoid accidental startup or damage caused by accidentally touching the pressure plate during operation, thereby ensuring the safety of the equipment; when the multi-functional cylinder needs to be cleaned, the fixed cylinder can be pressed on the pressure plate to connect the second gear ring with the inner gear ring and the outer gear ring, so that when the driving mechanism is running, it can drive the inner gear ring and the scraper rod to rotate through the second gear ring, so that the scraper rod cleans the inner wall of the multi-functional cylinder; when the material needs to be separated into solid and liquid, the fixed cylinder can be removed and installed at the bottom of the multi-functional cylinder, and the material can be filtered through the filter holes on the fixed cylinder; by cleverly combining the anti-pressure mechanism with the connecting mechanism, the cleaning mechanism and the threaded cylinder, the multi-functional extraction tank realizes multiple functions such as safety protection, cleaning and filtering without adding additional components, simplifies the operation process and improves work efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0028] Figure 1 The present invention is a process flow chart for preparing the astragalus polysaccharide powder;

[0029] Figure 2 The three-dimensional structure of the multifunctional extraction tank in the present invention Figure 1 ;

[0030] Figure 3 The three-dimensional structure of the multifunctional extraction tank in the present invention Figure 2 ;

[0031] Figure 4 The three-dimensional structure of the multifunctional extraction tank in the present invention Figure 3 ;

[0032] Figure 5 It is a schematic diagram of the interior of the multifunctional tube of the present invention;

[0033] Figure 6 It is a schematic diagram of the assembly structure of the stirring mechanism, the cleaning mechanism and the connecting mechanism in the present invention;

[0034] Figure 7 is a three-dimensional diagram of the anti-pressure mechanism in the present invention;

[0035] Figure 8 is a three-dimensional diagram of the connecting mechanism in the present invention;

[0036] Fig. 9 It is a schematic diagram of the connection between the fixed cylinder and the threaded cylinder in the present invention;

[0037] Fig.10 It is a schematic diagram of the groove of the fixing cylinder in the present invention when it is placed on the pressing plate;

[0038] 10. The invention relates to a cylinder having a plurality of moving parts, wherein the plurality of moving parts are provided with a plurality of moving parts, and the plurality of moving parts are provided with a plurality of moving parts. The plurality of moving parts are provided with a plurality of moving parts. DETAILED DESCRIPTION

[0039] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0040] The astragalus polysaccharide powder preparation of the invention is prepared from the following medicines in parts by weight: 1000-2000 parts of astragalus, 15 parts of sustained-release auxiliary materials, and 10 parts of povidone K30, wherein the sustained-release auxiliary material is hydroxypropyl methylcellulose.

[0041] Example 1: Figure 1 As shown, a preparation process of astragalus polysaccharide powder comprises the following steps:

[0042] Step 1, weighing: calibrate the electronic scale before operation, confirm that the electronic scale is within the calibration validity period, and check whether the name, quantity and other information of the medicinal material are consistent with the production prescription;

[0043] Among them, the Astragalus slices were checked and verified, including the product name, batch number, quantity, manufacturer, qualified status, and the sample weight was consistent with the batch production instructions;

[0044] Step 2, decoction: put 160kg of Astragalus into a multifunctional extraction tank, add 1wt% CaO aqueous solution to submerge the medicinal materials and soak for 1 hour, then add 8 times of water, decoct for 3 times (8 times of water for the first time, 6 times of water for the second time, and 6 times of water for the third time), decoction temperature is 90°C, each decoction time is 90min, the filtrate is filtered and then put into the extract storage tank, then the filter residue is discharged, and then the multifunctional extraction tank is cleaned for standby use;

[0045] During the decoction, the boiling state is often observed, and the boiling state is adjusted by adjusting the gas valve opening when necessary; by precisely controlling the decoction conditions, we found that compared with the traditional decoction method, this process can extract more astragalus polysaccharides in the same time, and the extraction efficiency is increased by about 20%. The specific data are as follows: the astragalus polysaccharide extraction rate after one decoction by the traditional method is 65%, while the astragalus polysaccharide extraction rate of this process is 78%;

[0046] Step 3, concentration: open the condenser cooling water valve, open the concentrator vacuum, open the feed valve, suck the extract from the extract storage tank to the position just out of the concentrator sight glass, stop feeding, open the heater steam valve, adjust the steam valve opening after the liquid boils, maintain the vacuum degree within the required range for stable concentration, open the feed valve appropriately for continuous feeding, maintain the liquid level in the middle of the concentrator sight glass, and after all the extracts are fed, continue to concentrate to the material-liquid ratio (1:1), stop concentrating, close the steam valve, close the vacuum valve and empty it, and pump the concentrated material into the alcohol precipitation tank;

[0047] Among them, the concentration vacuum degree is: -0.04~-0.06MPa; the concentration temperature is: 70-80℃, the double-effect liquid level is observed frequently, and the liquid level is maintained within the observation range by adjusting the opening of the feed valve. The boiling situation is observed frequently. If violent boiling occurs, the vent valve can be opened to reduce the vacuum degree to prevent violent boiling and material leakage; vacuum concentration can effectively reduce the solvent evaporation loss during the heating process, and the concentration efficiency in this step is increased by 15% compared with the traditional open concentration;

[0048] Step 4, alcohol precipitation: After the concentrate is pumped into the alcohol precipitation tank, start stirring and slowly add 95% ethanol to the alcohol precipitation tank until the alcohol content is 60%, turn off stirring, let it stand for 3 hours, filter, and then put the precipitate into the alcohol precipitation tank, turn on stirring, and slowly add 95% ethanol to the alcohol precipitation tank again until the alcohol content is 80%, turn off stirring, let it stand for 3 hours, filter, take the precipitate, put it into the multi-functional extraction tank and dissolve it in water;

[0049] Step 5, adding a sustained-release agent: adding 1.5 kg of sodium hydroxypropylcellulose and 1 kg of povidone K30 to a multifunctional extraction tank, heating to 60° C., stirring and dissolving, and then pumping into a liquid storage tank for spray drying;

[0050] Step 6, spray drying: turn on the blower, induced draft fan, air electric heating, high-speed rotating nozzle and tail gas spray absorption circulating water pump in sequence. When the inlet air temperature is stable at 160°C, turn on the feed pump, receive the material in the powder receiving room (D-level clean area), weigh it, seal it for storage, and send it to the temporary storage room of raw and auxiliary materials of the powder production line in the GMP workshop. Turn off the machine after drying.

[0051] Among them, the blower is 50HZ fixed frequency, the induced draft fan is 40HZ frequency conversion control, the high-speed rotating nozzle is 200V voltage regulation control, the feed pump is frequency conversion control, and the operating frequency is controlled within 30HZ, from low to high, and gradually adjusted according to the dryness of the discharge; the moisture content of the discharge is ≤3%; the feed amount is ≤120kg; pay attention to observe the dryness of the material, and reduce the feed amount or stop feeding when necessary, and then dry after the system is stable;

[0052] Step 7, mixing: transfer from the temporary storage room of raw materials to the unpacking room for unpacking, weighing, feeding, closing the feed cover of the silo after feeding, setting the mixing time to 40 minutes, withdrawing the container to the outside of the safety line, and then pressing the start button to start the mixing operation. After mixing, put it in a clean and dry barrel, cover the barrel cover, place the material label card, indicating the product name, batch, specification, batch number, date, operator, inspection status, etc., and hand it over to the semi-finished product intermediate station, notify QA to take samples, and test it according to the semi-finished product inspection standard of Astragalus polysaccharide powder. After passing the test, it will flow into the next process;

[0053] Among them, all indicators should be qualified according to the semi-finished product quality standards; the temperature of the operating room should be controlled at 18-24℃, and the relative humidity should be controlled below 50%; the equipment should be clean and dry, and the barrel cover should be tightened in time after the semi-finished product is loaded into the barrel to prevent moisture absorption;

[0054] Step 8, inner packaging: Pick up the semi-finished product of astragalus extract in the stainless steel barrel at the intermediate station, put it into the cleaned packaging machine, set the vertical roll film packaging machine to 502g / bag according to the 500g / bag weight specified in the packaging instruction, check whether the printed information on the packaging bag is correct, and then carry out packaging after verification. Put the packaged product bags into the sealing machine for sealing at a temperature between 205-210℃, and pay attention to not making the aluminum-plastic bag misaligned or wrinkled after heating, and seal it tightly; the packaged astragalus polysaccharide powder is transferred to the outer packaging room through the transfer window;

[0055] Among them, the filling quantity is checked every 20 minutes; when there is a deviation in the filling quantity, it is adjusted in time, and the filling quantity of all semi-finished products packaged in the previous 20 minutes is rechecked. For products of 500g and 505g, the filling quantity is controlled within 500g-505g, and the average filling quantity is not less than 500g;

[0056] Step 9, Outsourcing: Before packaging, collect and check whether the packaging materials and the specifications and quantities of the products to be packaged are consistent with the packaging instruction sheet, check whether the batch number and label are consistent with the packaging instruction sheet, and start packaging after they are accurate.

[0057] This process uses a multifunctional extraction tank to decoct astragalus, and improves the extraction efficiency by precisely controlling the decoction temperature, time and water volume; in the alcohol precipitation step, impurities in the extract are effectively removed by gradually adding ethanol and standing to precipitate; finally, the concentrated solution is dried into powder by spray drying technology, which further improves the purity of astragalus polysaccharides and facilitates storage and use. In addition, this process also focuses on environmental protection and energy saving. During the extraction and purification process, energy consumption and waste generation are reduced by reasonably adjusting parameters such as vacuum degree and temperature.

[0058] The preparation of astragalus polysaccharide powder prepared by the above process can reduce the feeding times of large animals and reduce the stress response of raised animals because it contains sustained-release excipients. The preparation of astragalus polysaccharide powder prepared by the above process has the effects of invigorating qi and strengthening the body, enhancing the body's resistance, etc. It can be used in veterinary clinical practice for the preventive treatment of infectious bursal disease in chickens.

[0059] Example 2: Figure 1 As shown, when other parts are the same as those in Example 1, the difference between this embodiment and Example 1 is that in step 6, when the air inlet temperature is stabilized at 170°C, the feed pump is turned on. In step 2, the decoction temperature is 105°C, and the decoction time is 120 minutes each time, which increases the extraction rate of astragalus polysaccharide by about 5% compared with decoction at 90°C and decoction time of 90 minutes each time, reaching 83%. This also shows that increasing the decoction temperature and decoction time within a certain range is conducive to the release of polysaccharide components.

[0060] Example 3: Figure 2-Figure 10 As shown, while other parts are the same as those in Example 1, the difference between this embodiment and Example 1 is that the multifunctional extraction tank includes a multifunctional cylinder 100, a heating cylinder 101, a stirring mechanism 120, a cleaning mechanism 130, a connecting mechanism 140 and an anti-pressure mechanism 150.

[0061] A plurality of supporting legs are installed on the bottom surface of the multifunctional cylinder 100. The heating cylinder 101 is fixedly mounted on the multifunctional cylinder 100, and the heating cylinder 101 is used to heat the multifunctional cylinder 100 and the materials in the multifunctional cylinder 100. The stirring mechanism 120 is installed on the multifunctional cylinder 100, and the stirring mechanism 120 is used to stir the materials in the multifunctional cylinder 100. The cleaning mechanism 130 is installed in the multifunctional cylinder 100, and the cleaning mechanism 130 is used to clean the inner wall of the multifunctional cylinder 100; the connecting mechanism 140 is used to connect the stirring mechanism 120 and the cleaning mechanism 130, and under normal conditions, the connecting mechanism 140 is not connected to the stirring mechanism 120 and the cleaning mechanism 130. The anti-pressure mechanism 150 is covered on the connecting mechanism 140.

[0062] Specifically, the material is added into the multifunctional cylinder 100, and the heating cylinder 101 is started to heat the multifunctional cylinder 100, thereby heating the material in the multifunctional cylinder 100, and then the material in the heating cylinder 101 is stirred and mixed by the stirring mechanism 120. When the multifunctional cylinder 100 needs to be cleaned, the connecting mechanism 140 is moved downward to connect the connecting mechanism 140 with the stirring mechanism 120 and the cleaning mechanism 130. At this time, the stirring mechanism 120 is started again, and the stirring mechanism 120 drives the cleaning mechanism 130 to rotate through the connecting mechanism 140, thereby rotating the cleaning mechanism 130 and cleaning the multifunctional cylinder 100.

[0063] like Figure 2 , Figure 3 and Figure 5 As shown, the multifunctional extraction tank further includes a fixing ring 102, a feed hopper 103, a sealing cover 104, a liquid discharge pipe 107, a second valve 108 and a gas valve 110. The fixing ring 102 is mounted on the inner wall of the multifunctional barrel 100; the feed hopper 103 is mounted on the top surface of the multifunctional barrel 100; the sealing cover 104 is hinged to the feed hopper 103; the liquid discharge pipe 107 is mounted on the bottom of the multifunctional barrel 100; the second valve 108 is mounted on the liquid discharge pipe 107; and the gas valve 110 is mounted on the multifunctional barrel 100.

[0064] like Figure 5 and Figure 6 As shown, the stirring mechanism 120 includes a fixed gear ring 121, a motor 122, an outer gear ring 123, two vertical rods 124, a plurality of stirring rods 125 and two first gears 126. The fixed gear ring 121 is mounted on the inner top surface of the multifunctional barrel 100; the motor 122 is mounted on the top surface of the multifunctional barrel 100; the outer gear ring 123 is located inside the multifunctional barrel 100, and the outer gear ring 123 is fixedly connected to the lower end of the power output shaft of the motor 122; the two vertical rods 124 are both rotatably connected to the outer gear ring 123; the plurality of stirring rods 125 are respectively mounted on the two vertical rods 124; the two first gears 126 are respectively mounted on the upper ends of the two vertical rods 124, and the two first gears 126 are both meshed and connected with the fixed gear ring 121.

[0065] Specifically, when the motor 122 rotates, it will drive the outer gear ring 123 to rotate, and then drive the two vertical rods 124 to rotate around the motor 122, and then drive the multiple stirring rods 125 to rotate, so as to stir the material in the multi-functional barrel 100; and when the two vertical rods 124 rotate, it will drive the two first gears 126 to rotate. Since the first gears 126 are meshed and connected with the fixed gear ring 121, the first gears 126 will rotate under the influence of the fixed gear ring 121, and then drive the vertical rods 124 to rotate, and then drive the multiple stirring rods 125 to rotate around the vertical rods 124, so as to further stir the material in the multi-functional barrel 100.

[0066] like Figure 5 and Figure 6 As shown, the cleaning mechanism 130 includes an inner toothed ring 131, a slide groove 132 and two scraping rods 133. The inner toothed ring 131 is located in the multifunctional cylinder 100, and the height of the inner toothed ring 131 is consistent with that of the outer toothed ring 123; the slide groove 132 is provided on the outer side of the inner toothed ring 131, and the slide groove 132 is slidably connected to the fixed ring 102; the two scraping rods 133 are both installed on the bottom surface of the inner toothed ring 131, and the two scraping rods 133 are in contact with the inner wall of the multifunctional cylinder 100.

[0067] Specifically, when the inner gear ring 131 rotates, it drives the two scraping rods 133 to rotate, and then the scraping rods 133 scrape the inner wall of the multifunctional cylinder 100, so as to clean up the materials attached to the multifunctional inner wall.

[0068] like Figure 5 , Figure 6 and Figure 8 As shown, the connection mechanism 140 includes a slide bar 141, a second gear 142, a pressure plate 143, a spring 144 and a stop ring 145. The slide bar 141 passes through the top surface of the multifunctional cylinder 100 and is slidably connected to the multifunctional cylinder 100; the second gear 142 is mounted on the lower end of the slide bar 141, and the second gear 142 matches the inner gear ring 131 and the outer gear ring 123; the pressure plate 143 is mounted on the upper end of the slide bar 141; the spring 144 is sleeved on the slide bar 141, and the two ends of the spring 144 are respectively connected to the bottom surface of the pressure plate 143 and the top surface of the multifunctional cylinder 100; the stop ring 145 is mounted on the top surface of the multifunctional cylinder 100.

[0069] Specifically, under normal conditions, the second gear 142 is not in contact with the inner gear ring 131 and the outer gear ring 123 due to the elastic force of the spring 144. By pressing the second gear 142 downward, the slide bar 141 is driven to move downward, and then the second gear 142 is driven to move downward, so that the second gear 142 is meshed and connected with the inner gear ring 131 and the outer gear ring 123. At this time, if the outer gear ring 123 is rotated, the second gear 142 is meshed and driven to rotate, and then the inner gear ring 131 is meshed and driven to rotate.

[0070] like Figure 4 As shown, the multifunctional extraction tank further includes a discharge pipe 105, a first valve 106 and a threaded barrel 109. The discharge pipe 105 is mounted on the bottom surface of the multifunctional barrel 100; the first valve 106 is mounted on the discharge pipe 105; the first valve 106 is a solenoid valve, the threaded barrel 109 is mounted on the bottom surface of the multifunctional barrel 100, and the discharge pipe 105 is located inside the threaded barrel 109.

[0071] Specifically, by opening the first valve 106 , the material in the multifunctional cylinder 100 will be discharged from the discharge pipe 105 .

[0072] like Figure 2, Figure 7 , Fig. 9 and Fig.10 As shown, the anti-pressure mechanism 150 includes a fixed cylinder 151, a groove 152 and two handles 153. The bottom of the fixed cylinder 151 is open, the inner diameter of the opening of the fixed cylinder 151 is larger than the outer diameter of the limiting ring 145, the opening of the fixed cylinder 151 can be threadedly connected with the threaded cylinder 109, and a plurality of filter holes are provided on the top of the fixed cylinder 151; the groove 152 is provided on the top surface of the fixed cylinder 151, and the groove 152 is plugged and matched with the pressure plate 143; the two handles 153 are both installed on the side of the fixed cylinder 151, and the handles 153 are made of solid stainless steel.

[0073] Specifically, under normal conditions, the fixed cylinder 151 covers the limiting ring 145 so that the pressure plate 143 is located in the fixed cylinder 151 , thereby preventing the second gear 142 from contacting the outer gear ring 123 and the inner gear ring 131 due to accidental contact with the pressure plate 143 .

[0074] When it is necessary to press the pressure plate 143 downward, the fixing cylinder 151 is rotated 180° up and down so that the groove 152 faces downward, and then the groove 152 is placed on the pressure plate 143. The weight of the fixing cylinder 151 will press the pressure plate 143 and the spring 144 downward, thereby moving the pressure plate 143 downward, and the second gear 142 is meshed and connected with the outer gear ring 123 and the inner gear ring 131.

[0075] When it is necessary to filter the material discharged from the discharge pipe 105, the fixed cylinder 151 placed on the multifunctional cylinder 100 is removed, and then the opening of the fixed cylinder 151 is threadedly connected to the threaded cylinder 109, and then the first valve 106 is opened to discharge the material in the multifunctional cylinder 100 into the fixed cylinder 151 through the discharge pipe 105. Since a plurality of filter holes are provided on the fixed cylinder 151, the liquid in the material will pass through the filter holes and flow to the outside of the fixed cylinder 151, while the fixed material will remain in the fixed cylinder 151 and the multifunctional cylinder 100, thereby completing the solid-liquid separation of the material.

[0076] Working principle: When in use, open the sealing cover 104, add the astragalus from the feed hopper 103 into the multifunctional cylinder 100, then add 1% CaO aqueous solution into the multifunctional cylinder 100 to submerge the medicinal materials and soak them for 1 hour, then add 8 times of water, and then start the heating cylinder 101 to heat the multifunctional cylinder 100, and then boil the astragalus and 1% CaO aqueous solution in the multifunctional cylinder 100. A total of 3 times of water needs to be added (8 times of water for the first time, 6 times of water for the second time, and 6 times of water for the third time), and the boiling temperature is controlled at 90°C.

[0077] During boiling, by starting the motor 122, the power output shaft of the motor 122 drives the outer gear ring 123 to rotate, and then drives the two vertical rods 124 to rotate around the motor 122, and then drives the multiple stirring rods 125 to rotate, so as to stir the material in the multi-functional cylinder 100, so that the material in the multi-functional cylinder 100 is heated evenly, which is beneficial to improving the boiling efficiency; and when the two vertical rods 124 rotate, the two first gears 126 will be driven to rotate. Since the first gear 126 is meshed and connected with the fixed gear ring 121, the first gear 126 will rotate, and then drive the vertical rod 124 to rotate, and then drive the multiple stirring rods 125 to rotate around the vertical rod 124, so that the material in the multi-functional cylinder 100 is further heated evenly, and the boiling efficiency is further improved.

[0078] After the decoction is completed, the fixed cylinder 151 placed on the multifunctional cylinder 100 is removed, and then the opening of the fixed cylinder 151 is threadedly connected to the threaded cylinder 109, and then the first valve 106 is opened to discharge the material in the multifunctional cylinder 100 into the fixed cylinder 151 through the discharge pipe 105. Since a plurality of filter holes are provided on the fixed cylinder 151, the liquid in the material will pass through the filter holes and flow out of the fixed cylinder 151, while the fixed material will remain in the fixed cylinder 151 and the multifunctional cylinder 100, thereby completing the solid-liquid separation of the material. After the liquid is emptied, the fixed cylinder 151 is separated from the threaded cylinder 109, and the fixed material (filter residue) in the multifunctional cylinder 100 is taken out from the multifunctional cylinder 100.

[0079] Then, the first valve 106 is closed, and clean water is added into the multi-functional cylinder 100 through the feed hopper 103, and then the groove 152 of the fixed cylinder 151 is facing downward, and then the groove 152 is placed on the pressure plate 143, and the weight of the fixed cylinder 151 will press the pressure plate 143 and the spring 144 downward, so that the pressure plate 143 moves downward, and then the pressure plate 143 and the second gear 142 are meshed and connected with the outer gear ring 123 and the inner gear ring 131, and then the motor 122 is started, so that the power output shaft of the motor 122 drives the outer gear ring 123 to rotate, and then drives the second gear 142 to rotate, and then drives the inner gear ring 131 to rotate, and then drives the two scraping rods 133 to rotate, so that the scraping rods 133 scrape the inner wall of the multi-functional cylinder 100, so as to clean up the materials attached to the multi-functional inner wall, and then, the first valve 106 is opened again, and the water and debris in the multi-functional cylinder 100 are discharged through the discharge pipe 105, so that the multi-functional cylinder 100 is cleaned.

[0080] When the motor 122 is running, the rotation of the vertical rod 124 and the stirring rod 125 will also speed up the mixing efficiency of the materials in the multifunctional barrel 100, thereby improving the production efficiency.

[0081] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

[0082] The preferred embodiments of the present invention disclosed above are only used to help explain the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to only specific implementation methods. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A preparation process of astragalus polysaccharide powder, characterized in that: The following steps are involved: Step 1, weighing: calibrate the electronic scale before operation, confirm that the electronic scale is within the calibration validity period, and check whether the medicinal material name and quantity information are consistent with the production prescription; among them, check and verify the Astragalus slices, including the name, batch number, quantity, manufacturer, qualified status, and the sample weight is consistent with the batch production instruction; Step 2, decoction: put the weighed astragalus into a multifunctional extraction tank, add 0.5-2wt% CaO aqueous solution to submerge the medicinal material and soak for 1-2 hours, then add 6-8 times of water, decoct for 3-5 times, decoction temperature is 90-105°C, each decoction time is 90-120min, the filtrate is filtered and then put into the extract storage tank, then the filter residue is discharged, and the multifunctional extraction tank is cleaned for standby use; Step 3, concentration: Concentrate through the extract storage tank, open the heater steam valve, maintain the vacuum degree, and when the material-liquid ratio is 1:1, stop concentrating, close the steam valve, close the vacuum valve and empty it, and pump the concentrated material into the alcohol precipitation tank; The concentration vacuum degree is -0.04~-0.06MPa; the concentration temperature is 70-80℃; Step 4, alcohol precipitation: After the concentrate is pumped into the alcohol precipitation tank, start stirring and slowly add 90-95vt% ethanol to the alcohol precipitation tank until the alcohol content is 60%, turn off stirring, let it stand for 3-4 hours, filter, and then put the precipitate into the alcohol precipitation tank, turn on stirring, and slowly add 90-95vt% ethanol to the alcohol precipitation tank again until the alcohol content is 80%, turn off stirring, let it stand for 3-4 hours, filter and take the precipitate, put it into the multi-functional extraction tank and dissolve it in water; Step 5, adding sustained-release agent: adding sodium hydroxypropyl cellulose and povidone K30 into the multifunctional extraction tank, heating to 60°C, stirring and dissolving, and then pumping into the liquid storage tank for spray drying; Step 6, spray drying: when the air inlet temperature is stable at 160-170°C, start the feed pump, receive the material in the powder collecting room, weigh it, and seal it for storage; Step 7, mixing: transfer from the temporary storage room of raw materials to the unpacking room for unpacking, weighing, feeding, closing the feed cover of the silo after feeding, setting the mixing time to 40-50 minutes, and after mixing, put it in a clean and dry barrel, cover the barrel cover, and deliver it to the semi-finished product intermediate station, and test it according to the semi-finished product inspection standard of astragalus polysaccharide powder, and flow into the next process after passing the test; Step 8, inner packaging: Pick up the semi-finished product of astragalus extract in the stainless steel barrel at the intermediate station, put it into the cleaned packaging machine, put the packaged product bags into the sealing machine for sealing, and then transfer the packaged astragalus polysaccharide powder to the outer packaging room; Step 9, Outsourcing: Before packaging, collect and check whether the specifications and quantity of the packaging materials and the products to be packaged are consistent with the packaging instruction sheet, check whether the batch number and label are consistent with the packaging instruction sheet, and package after they are accurate.

2. The preparation process of astragalus polysaccharide powder according to claim 1, characterized in that: The multifunctional extraction tank comprises: Multifunctional cartridge (100); A heating cylinder (101) fixedly sleeved on the multifunctional cylinder (100); A stirring mechanism (120), installed on the multifunctional cylinder (100), and used for stirring the material in the multifunctional cylinder (100); A cleaning mechanism (130) is installed in the multifunctional cylinder (100) and is used to clean the inner wall of the multifunctional cylinder (100); A connecting mechanism (140), used for connecting the stirring mechanism (120) and the cleaning mechanism (130); An anti-pressure mechanism (150) is covered on the connecting mechanism (140); When the connecting mechanism (140) is connected to the stirring mechanism (120) and the cleaning mechanism (130), when the stirring mechanism (120) is in operation, the cleaning mechanism (130) will rotate under the influence of the connecting mechanism (140) and clean the multifunctional cylinder (100).

3. The preparation process of astragalus polysaccharide powder according to claim 2, characterized in that: The multifunctional extraction tank also includes: A fixing ring (102) mounted on the inner wall of the multifunctional cylinder (100); A feed hopper (103) mounted on the top surface of the multifunctional cylinder (100); A sealing cover (104) is hingedly connected to the feed hopper (103); A liquid discharge pipe (107) installed at the bottom of the multifunctional cylinder (100); A second valve (108) installed on the discharge pipe (107); A gas valve (110) is installed on the multifunctional cartridge (100).

4. The preparation process of astragalus polysaccharide powder according to claim 3, characterized in that: The stirring mechanism (120) comprises: A fixed gear ring (121) mounted on the inner top surface of the multifunctional cylinder (100); A motor (122) mounted on the top surface of the multifunctional cylinder (100); An outer gear ring (123) is located in the multifunctional cylinder (100) and is fixedly connected to the lower end of the power output shaft of the motor (122); Two vertical rods (124) are both rotatably connected to the outer gear ring (123); A plurality of stirring rods (125) are respectively mounted on the two vertical rods (124); Two first gears (126) are respectively mounted on the upper ends of the two vertical rods (124) and are both meshedly connected with the fixed gear ring (121).

5. The preparation process of astragalus polysaccharide powder according to claim 4, characterized in that: The cleaning mechanism (130) comprises: An inner toothed ring (131) is located inside the multifunctional tube (100) and has the same height as the outer toothed ring (123); A sliding groove (132) is provided on the outer side surface of the inner gear ring (131) and is slidably connected to the fixing ring (102); Two scraping rods (133) are both mounted on the bottom surface of the inner gear ring (131) and are in contact with the inner wall of the multifunctional cylinder (100).

6. The preparation process of astragalus polysaccharide powder according to claim 5, characterized in that: The connecting mechanism (140) comprises: A sliding rod (141) passes through the top surface of the multifunctional cylinder (100) and is slidably connected to the multifunctional cylinder (100); A second gear (142) is mounted on the lower end of the slide bar (141) and matches the inner gear ring (131) and the outer gear ring (123); A pressing plate (143) mounted on the upper end of the sliding rod (141); A spring (144), two ends of which are respectively connected to the bottom surface of the pressing plate (143) and the top surface of the multifunctional cylinder (100); A limiting ring (145) is installed on the top surface of the multifunctional cylinder (100).

7. The process for preparing astragalus polysaccharide powder according to claim 6, characterized in that: The multifunctional extraction tank also includes: A discharge pipe (105) is installed on the bottom surface of the multifunctional cylinder (100); A first valve (106) installed on the discharge pipe (105); The threaded barrel (109) is installed on the bottom surface of the multifunctional barrel (100), and the discharge pipe (105) is located inside the threaded barrel (109).

8. The process for preparing astragalus polysaccharide powder according to claim 7, characterized in that: The anti-pressure mechanism (150) comprises: The fixed cylinder (151) has an opening at the bottom, the inner diameter of the opening of the fixed cylinder (151) is larger than the outer diameter of the limiting ring (145), the opening of the fixed cylinder (151) can be threadedly connected to the threaded cylinder (109), and a plurality of filtering holes are formed at the top of the fixed cylinder (151); A groove (152) is provided on the top surface of the fixing cylinder (151) and is plug-fitted with the pressing plate (143); Two handles (153) are both installed on the side surfaces of the fixing tube (151).

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