Novel urine potassium excretion fraction calculation method

Abstract

The invention discloses a novel urine potassium excretion score calculation method, and solves the problems that effective data support cannot be provided when a patient is repeatedly transferred to multiple hospitals due to the fact that normal range values of urine potassium excretion parameters detected by different hospitals are greatly different, and the calculation of the urine potassium excretion score by using a ratio method cannot provide effective data support when the patient is repeatedly transferred to multiple hospitals. And a large calculation error exists. According to the method, different numerical values can be converted into a certain fixed reasonable interval, a specific interval can be specified in the reasonable interval to calibrate a normal / abnormal range, and after different numerical values measured among different hospitals are respectively converted, corresponding diagnosis can be carried out by referring to the normal / abnormal range calibrated in the reasonable interval; effective data support can be provided when the patient is transferred to multiple hospitals; according to the method, the abnormal calculation range interval can be effectively avoided in the ratio calculation, the possibility of numerical value overflow is avoided, and the calculation error of the urine potassium excretion fraction is reduced.

Description

Technical Field

[0001] The invention belongs to the field of medical technology, and in particular relates to a novel calculation method for urinary potassium excretion fraction. Background Art

[0002] Hypokalemia refers to a pathological state in which the serum potassium concentration is less than 3.5mmol / L, and is one of the most common electrolyte disorders in clinical practice. Hypokalemia mainly affects the electrical excitability of the heart and muscles, and can cause dysfunction of multiple systems such as cardiovascular, muscle, nervous, kidney, digestive, and endocrine systems. In severe cases, life-threatening symptoms such as respiratory muscle paralysis and cardiac arrest may occur.

[0003] Identifying the cause of hypokalemia is an important prerequisite for correcting hypokalemia. The etiology of hypokalemia is of great significance. The potassium regulation mechanism in the human body is complex, and hypokalemia involves many causes, including: insufficient potassium intake; loss of potassium in the digestive tract, such as vomiting and diarrhea; loss of potassium in large amounts of sweat, such as after high-temperature work and strenuous exercise; transfer hypokalemia, including hyperthyroidism, hyperinsulinemia, enhanced Na+-K+-ATPase activity, alkalosis such as hyperventilation syndrome, increased intracellular H+ outflow, all due to increased transfer of K+ into cells, causing a decrease in serum K+; increased urinary potassium excretion, also known as "renal potassium loss", is mainly related to excessive secretion of mineralocorticoids, excessive secretion or enhanced effect of glucocorticoids, and abnormal renal tubular function, such as primary aldosteronism, reninoma, renal artery stenosis, Liddle syndrome, Cushing syndrome, excessive intake of exogenous glucocorticoids, apparent mineralocorticoid excess syndrome, diuretic use, Batter syndrome, Gitelman syndrome, renal tubular acidosis, etc. Among them, hypokalemia caused by insufficient intake, loss of potassium in the digestive tract, loss of potassium through sweat, and transfer hypokalemia will have a corresponding decrease in urinary potassium excretion, which is not a disease with increased urinary potassium excretion. In diseases with increased urinary potassium excretion, urinary potassium excretion is still at a high level even if the blood potassium is very low. Therefore, the level of urinary potassium excretion is considered to be a key item in the primary assessment of hypokalemia, which indicates the direction of its cause.

[0004] When evaluating urinary potassium excretion, it is usually necessary to measure blood potassium, blood creatinine, urine potassium, and urine creatinine. However, the different methods, equipment, and reagents used by different hospitals to measure these four parameters will cause changes in the measured values, which will lead to large differences in the normal range values ​​tested by different hospitals. When patients go to multiple hospitals, they cannot provide effective data support. In addition, when using the traditional ratio method to calculate the urinary potassium excretion fraction, the calculation error is large. Summary of the invention

[0005] The technical problem to be solved by the present invention is to provide a novel method for calculating the urine potassium excretion fraction, so as to solve the technical problem that the normal range values ​​of urine potassium excretion parameters detected by different hospitals are quite different, resulting in the inability to provide effective data support when patients are transferred to multiple hospitals, and the use of the ratio method for calculating the urine potassium excretion fraction has a large calculation error.

[0006] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0007] A novel method for calculating urinary potassium excretion fraction comprises the following steps:

[0008] Step 1: Find the normal range of urine potassium excretion parameters of the patient's last hospital visit;

[0009] Step 2: Calculate the mapping relationship between the normal range of urine potassium excretion parameters of the patient's last hospital and the normal range of urine potassium excretion parameters of this hospital;

[0010] Step 3: Collect the urine potassium excretion parameter values ​​measured by the patient in the last hospital;

[0011] Step 4: Calculate the initial urine potassium data of the patient according to the urine potassium excretion parameter value collected in step 3 and the mapping relationship value calculated in step 2;

[0012] Step 5: After performing functional transformation on the initial data of the patient's urine potassium, calculate the patient's initial urine potassium excretion fraction;

[0013] Step 6: In this hospital, draw venous blood from the patient and collect the patient's urine;

[0014] Step 7: Detect the blood potassium and blood creatinine content in venous blood, and detect the urine potassium and urine creatinine content in urine;

[0015] Step 8: After performing functional transformation on the blood potassium, blood creatinine, urine potassium and urine creatinine content values ​​detected in step 7, the patient's current urine potassium excretion fraction is calculated.

[0016] Further, in step 2, the method for calculating the mapping relationship value between the normal range value of the urine potassium excretion parameter of the patient's last hospital and the normal range value of the urine potassium excretion parameter of this hospital is:

[0017] Z1=x1*c1+c0

[0018] Z2=x2*c1+c0

[0019] Among them, c1 and c0 represent the mapping relationship between the two groups of numerical values; Z1 represents the minimum value of the urinary potassium excretion parameter of this hospital, and Z2 represents the maximum value of the urinary potassium excretion parameter of this hospital; x1 represents the minimum value of the urinary potassium excretion parameter of the patient's last hospital, and x2 represents the maximum value of the urinary potassium excretion parameter of the patient's last hospital.

[0020] Further, in steps 1-4, the urine potassium excretion parameters include blood potassium, blood creatinine, urine potassium and urine creatinine. Further, in steps 5 and 8, the method for performing function transformation is:

[0021] P un =arctan(c1*Pu+c0)

[0022] P bn =arctan(c1*Pb+c0)

[0023] C un =arctan(c1*Cu+c0)

[0024] C bn =arctan(c1*Cb+c0)

[0025] Among them, P u Indicates the urine potassium content, P un Indicates P u Function transformation value; P b Indicates the blood potassium content, P bn Indicates P b Function transformation value; C u Indicates the content of urine creatinine, C un Represents C u Function transformation value; C b Indicates the content of blood creatinine, C bn Represents C b The function transformation value; c1 and c0 represent the mapping relationship between two sets of numerical values.

[0026] Furthermore, in step 5 and step 8, the calculation method of urinary potassium excretion fraction is:

[0027] F=(P un / C un ) / (P bn / C bn )

[0028] Among them, P un The function transformation value representing the urine potassium content; P bn The function transformation value representing the blood potassium content; C un The function transformation value representing the urine creatinine content; C bn Represents the function transformation value of blood creatinine content.

[0029] Furthermore, in step 6, the method for improving the accuracy of the patient's blood potassium, blood muscle, urine potassium, and urine muscle detection is: the patient stops potassium supplementation for 1 day, and drinks water within 15 minutes after fasting and emptying the bladder on the next day. The timer starts after drinking water, and venous blood and urine are drawn from the patient after 2 hours.

[0030] Furthermore, the amount of water a patient drinks is their body weight multiplied by 10, and the amount of water they drink is 10 ml for every kilogram of body weight.

[0031] Compared with the prior art, the present invention has the following beneficial effects:

[0032] The invention is scientifically and reasonably designed and easy to use. The method of the invention can transform different numerical values ​​into a fixed reasonable interval, and a specific interval can be specified within the reasonable interval to calibrate the normal / abnormal range. The different numerical values ​​measured in different hospitals can be transformed respectively, and the normal / abnormal range calibrated within the reasonable interval can be referred to for corresponding diagnosis, which is helpful for providing effective data support when the patient is transferred to multiple hospitals. The method of the invention can effectively avoid abnormal calculation range intervals in ratio calculation, avoid the possibility of numerical overflow, and reduce the calculation error of urine potassium excretion fraction. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 It is a structural flow chart of the present invention.

[0034] Figure 2 This is an example diagram showing that the values ​​after function transformation are within a fixed range.

[0035] Figure 3 This is an example diagram showing that the values ​​after function transformation are within a fixed range.

[0036] Figure 4 This is an example diagram showing that the values ​​after function transformation are within a fixed range. DETAILED DESCRIPTION

[0037] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0038] In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation or be constructed and operated in a specific orientation, and therefore they cannot be understood as limiting the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance.

[0039] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; of course, it can also be a mechanical connection or an electrical connection; in addition, it can also be a direct connection, or an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0040] like Figure 1 As shown, a novel method for calculating urinary potassium excretion fraction provided by the present invention solves the technical problems that the normal range values ​​of urinary potassium excretion parameters detected by different hospitals are quite different, resulting in the inability to provide effective data support when patients are transferred to multiple hospitals, and the use of the ratio method for calculating urinary potassium excretion fraction has a large calculation error.

[0041] The invention is scientifically and reasonably designed and easy to use. The method of the invention can transform different numerical values ​​into a fixed reasonable interval, and a specific interval can be specified within the reasonable interval to calibrate the normal / abnormal range. The different numerical values ​​measured in different hospitals can be transformed respectively, and the normal / abnormal range calibrated within the reasonable interval can be referred to for corresponding diagnosis, which is helpful for providing effective data support when the patient is transferred to multiple hospitals. The method of the invention can effectively avoid abnormal calculation range intervals in ratio calculation, avoid the possibility of numerical overflow, and reduce the calculation error of urine potassium excretion fraction.

[0042] The method of the present invention comprises the following steps:

[0043] Step 1: Find the normal range of urine potassium excretion parameters of the patient's last hospital visit;

[0044] Step 2: Calculate the mapping relationship between the normal range of urine potassium excretion parameters of the patient's last hospital and the normal range of urine potassium excretion parameters of this hospital;

[0045] Step 3: Collect the urine potassium excretion parameter values ​​measured by the patient in the last hospital;

[0046] Step 4: Calculate the initial urine potassium data of the patient according to the urine potassium excretion parameter value collected in step 3 and the mapping relationship value calculated in step 2;

[0047] Step 5: After performing functional transformation on the initial data of the patient's urine potassium, calculate the patient's initial urine potassium excretion fraction;

[0048] Step 6: In this hospital, draw venous blood from the patient and collect the patient's urine;

[0049] Step 7: Detect the blood potassium and blood creatinine content in venous blood, and detect the urine potassium and urine creatinine content in urine;

[0050] Step 8: After performing functional transformation on the blood potassium, blood creatinine, urine potassium and urine creatinine content values ​​detected in step 7, the patient's current urine potassium excretion fraction is calculated.

[0051] In this embodiment, in step 5, after the initial data of the patient's urine potassium is transformed by function, the transformed value is within a fixed reasonable range. In step 8, after the blood potassium, blood creatinine, urine potassium, and urine creatinine content values ​​detected in step 7 are transformed by function, the transformed values ​​are within a fixed reasonable range. After specifying a specific interval within the reasonable range to calibrate the normal / abnormal range, the patient can be diagnosed accordingly to determine the change in the patient's condition.

[0052] In this embodiment, the last hospital visited by the patient may be another hospital or the present hospital.

[0053] In some embodiments, in step 2, the method for calculating the mapping relationship value between the normal range value of the urine potassium excretion parameter of the patient's last hospital and the normal range value of the urine potassium excretion parameter of the current hospital is:

[0054] Z1=x1*c1+c0

[0055] Z2=x2*c1+c0

[0056] Among them, c1 and c0 represent the mapping relationship between the two groups of numerical values; Z1 represents the minimum value of the urinary potassium excretion parameter of this hospital, and Z2 represents the maximum value of the urinary potassium excretion parameter of this hospital; x1 represents the minimum value of the urinary potassium excretion parameter of the patient's last hospital, and x2 represents the maximum value of the urinary potassium excretion parameter of the patient's last hospital.

[0057] In some embodiments, in steps 1-4, the urine potassium excretion parameter includes blood potassium, blood creatinine, urine potassium and urine creatinine.

[0058] In some embodiments, in step 5 and step 8, the method for performing function transformation is:

[0059] P un =arctan(c1*Pu+c0)

[0060] P bn =arctan(c1*Pb+c0)

[0061] C un =arctan(c1*Cu+c0)

[0062] C bn =arctan(c1*Cb+c0)

[0063] Among them, P u Indicates the urine potassium content, P un Indicates P u Function transformation value; P b Indicates the blood potassium content, P bn Indicates P b Function transformation value; C u Indicates the content of urine creatinine, C un Represents C u Function transformation value; C b Indicates the content of blood creatinine, C bn Represents C b The function transformation value; c1 and c0 represent the mapping relationship between two sets of numerical values.

[0064] In this embodiment, P un , P bn , C un , C bn are all within a fixed and reasonable range. Figure 2-4 As shown, Figure 2-4 The original measurement parameter x in P u , P b , C u or C b The transformed value y represents P un , P bn , C un or C bn In this example, we can see that P un , P bn , C un or C bn The value of is always in the range of 0-1.6.

[0065] In some embodiments, in step 5 and step 8, the calculation method of urinary potassium excretion fraction is:

[0066] F=(P un / C un ) / (P bn / C bn )

[0067] Among them, P un The function transformation value representing the urine potassium content; P bn The function transformation value representing the blood potassium content; C un The function transformation value representing the urine creatinine content; C bn Represents the function transformation value of blood creatinine content.

[0068] In some embodiments, in step 6, the method for improving the accuracy of the patient's blood potassium, blood muscle, urine potassium, and urine muscle detection is: the patient stops potassium supplementation for 1 day, and drinks water within 15 minutes after fasting and emptying the bladder the next day. The timer starts after drinking water, and the patient's venous blood is drawn and the patient's urine is collected after 2 hours.

[0069] In some embodiments, the amount of water a patient drinks is body weight*10, where every kilogram of body weight corresponds to 10 ml of water.

[0070] Finally, it should be noted that the above embodiments are only preferred embodiments of the present invention to illustrate the technical solutions of the present invention, rather than limiting them, and certainly not limiting the patent scope of the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions recorded in the aforementioned embodiments, or replace some or all of the technical features therein by equivalents. These modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present invention. In other words, any changes or modifications made to the main design concept and spirit of the present invention that have no substantive significance, and the technical problems they solve are still consistent with the present invention, should be included in the protection scope of the present invention. In addition, the direct or indirect application of the technical solutions of the present invention in other related technical fields is also included in the patent protection scope of the present invention.

Claims

1. A new method for calculating urinary potassium excretion fraction, It is characterized in that The steps include: Step 1: Find the normal range of urine potassium excretion parameters of the patient's last hospital visit; Step 2: Calculate the mapping relationship between the normal range of urine potassium excretion parameters of the patient's last hospital and the normal range of urine potassium excretion parameters of this hospital; Step 3: Collect the urine potassium excretion parameter values ​​measured by the patient in the last hospital; Step 4: Calculate the initial urine potassium data of the patient according to the urine potassium excretion parameter value collected in step 3 and the mapping relationship value calculated in step 2; Step 5: After performing functional transformation on the initial data of the patient's urine potassium, calculate the patient's initial urine potassium excretion fraction; Step 6: In this hospital, draw venous blood from the patient and collect the patient's urine; Step 7: Detect the blood potassium and blood creatinine content in venous blood, and detect the urine potassium and urine creatinine content in urine; Step 8: After performing functional transformation on the blood potassium, blood creatinine, urine potassium and urine creatinine content values ​​detected in step 7, the patient's current urine potassium excretion fraction is calculated.

2. A novel method for calculating urinary potassium excretion fraction according to claim 1, It is characterized in that In step 2, the method for calculating the mapping relationship between the normal range of the urine potassium excretion parameter of the patient's last hospital and the normal range of the urine potassium excretion parameter of this hospital is: Z1=x1*c1+c0 Z2=x2*c1+c0 Among them, c1 and c0 represent the mapping relationship between the two groups of numerical values; Z1 represents the minimum value of the urinary potassium excretion parameter of this hospital, and Z2 represents the maximum value of the urinary potassium excretion parameter of this hospital; x1 represents the minimum value of the urinary potassium excretion parameter of the patient's last hospital, and x2 represents the maximum value of the urinary potassium excretion parameter of the patient's last hospital.

3. A novel method for calculating urinary potassium excretion fraction according to claim 1, Its characteristics are, In steps 1-4, the urinary potassium excretion parameters include serum potassium, serum creatinine, urine potassium, and urine creatinine.

4. A novel method for calculating urinary potassium excretion fraction according to claim 3, It is characterized in that In step 5 and step 8, the method for performing function transformation is: P un =arctan(c1*Pu+c0) P bn =arctan(c1*Pb+c0) C un =arctan(c1*Cu+c0) C bn =arctan(c1*Cb+c0) Among them, P u Indicates the urine potassium content, P un Indicates P u Function transformation value; P b Indicates the blood potassium content, P bn Indicates P b Function transformation value; C u Indicates the content of urine creatinine, C un Represents C u Function transformation value; C b Indicates the content of blood creatinine, C bn Represents C b The function transformation value; c1 and c0 represent the mapping relationship between two sets of numerical values.

5. A novel method for calculating urinary potassium excretion fraction according to claim 4, It is characterized in that In Steps 5 and 8, the fractional excretion of potassium in urine is calculated as: F=(P un / C un ) / (P bn / C bn ) Among them, P un The function transformation value representing the urine potassium content; P bn The function transformation value representing the blood potassium content; C un The function transformation value representing the urine creatinine content; C bn Represents the function transformation value of blood creatinine content.

6. A novel method for calculating urinary potassium excretion fraction according to claim 1, It is characterized in that In step 6, the method to improve the accuracy of the patient's blood potassium, blood muscle, urine potassium, and urine muscle detection is: the patient stops potassium supplementation for 1 day, and drinks water within 15 minutes after fasting and emptying the bladder on the next day. The timer starts after drinking water, and venous blood and urine are drawn from the patient after 2 hours.

7. A novel method for calculating urinary potassium excretion fraction according to claim 6, It is characterized in that The amount of water the patient should drink is body weight multiplied by 10, and the corresponding amount of water to be drunk is 10 ml for every kilogram of body weight.

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