Traditional Chinese medicine composition for treating allergic cough and asthmatic attack and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating allergic cough and asthmatic attack and a preparation method thereof. The traditional Chinese medicine composition comprises the following components by weight: 5-10 g of herba schizonepetae, 5-10 g of radix saposhnikoviae, 5-10 g of radix angelicae, 10-50 g of honeysuckle, 30-50 g of radix astragali, 5-15 g of rhizoma coptidis, 10-15 g of semen celosiae, 5-20 g of cortex phellodendri, 5-10 g of cortex mori radicis, 5-10 g of ginseng, 5-10 g of honey-fried licorice root, 5-10 g of folia perillae acutae, 2-5 g of fennel, 10-30 g of Chinese yam and 2-5 g of clove. According to the traditional Chinese medicine composition for treating the allergic cough and the asthmatic attack and the preparation method, through treatment based on syndrome differentiation, reasonable preparation of the traditional Chinese medicine prescription and optimization of the combination mode, the obtained prescription can more effectively treat the allergic cough and the asthmatic attack, and the allergic cough and the asthmatic attack can be fundamentally treated by orally taking the traditional Chinese medicine preparation; the cure rate is obviously improved, and the recurrence rate is reduced. Through clinical verification, the total effective rate is 98% (the cure rate is 70%); the effective rate is 28%; the inefficiency is 2%).

Description

Technical Field

[0001] The invention relates to the technical field of Chinese medicine compositions, in particular to a Chinese medicine composition for treating allergic cough and asthma attack and a preparation method thereof. Background Art

[0002] Cough variant asthma (CVA) is a chronic cough with cough as the only symptom and is difficult to improve for a long time (usually >8 weeks). It is a special form of asthma. CVA accounts for one-third of chronic cough and is the second largest cause. In addition to being related to one's own genetics, the onset of CVA is also affected by allergens and environmental factors. With the deterioration of air quality, high urbanization and high industrialization, adverse environmental impacts are becoming increasingly serious, and the age of patients is getting younger and younger. This is also a popular trend for various immune-related diseases in the future. The results of the epidemiological survey of childhood asthma show that the cumulative prevalence of childhood asthma in my country is increasing year by year. For Western medical diagnosis, since cough is the only and main symptom of the disease, a variety of auxiliary examinations are required clinically. Therefore, there are cases in which the CVA diagnostic criteria are not met in the early stage of the disease and it can only be classified as chronic cough, which often leads to misdiagnosis, missed diagnosis, and mistreatment. These reasons may cause some CAV patients to eventually develop into typical bronchial asthma.

[0003] The existing Chinese medicine compositions for treating allergic cough and asthma attacks have single ingredients and poor efficacy. They cannot be more effectively treated by syndrome differentiation, rational preparation of Chinese medicine prescriptions, and optimized combination methods. Summary of the invention

[0004] 1. Technical issues to be resolved

[0005] In view of the deficiencies in the prior art, the present invention provides a Chinese medicine composition for treating allergic cough and asthma attacks and a preparation method thereof. By means of syndrome differentiation and treatment, rational preparation of Chinese medicine prescriptions, and optimization of the combination method, the obtained prescription can more effectively treat allergic cough and asthma attacks.

[0006] (II) Technical solution

[0007] To achieve the above objectives, the present invention is implemented through the following technical scheme: a Chinese medicine composition for treating allergic cough and asthma attacks, which includes the following components by weight: 5-10 grams of Schizonepeta, 5-10 grams of Saposhnikovia, 5-10 grams of Angelica dahurica, 10-50 grams of Honeysuckle, 30-50 grams of Astragalus, 5-15 grams of Coptis chinensis, 10-15 grams of Amaranthus fruit, 5-20 grams of Phellodendron, 5-10 grams of Morus alba, 5-10 grams of Ginseng, 5-10 grams of Radix Glycyrrhizae Preparata, 5-10 grams of Perilla leaf, 2-5 grams of fennel, 10-30 grams of Chinese yam and 2-5 grams of cloves.

[0008] Preferably, it comprises the following components by weight: 7 grams of Schizonepeta, 7 grams of Saposhnikovia, 7 grams of Angelica dahurica, 30 grams of Honeysuckle, 40 grams of Astragalus, 10 grams of Coptis chinensis, 13 grams of Amaranthus fruit, 12 grams of Phellodendron, 7 grams of Morus alba bark, 7 grams of Ginseng, 7 grams of Radix Glycyrrhizae Preparata, 7 grams of Perilla leaf, 3 grams of fennel, 20 grams of yam and 3 grams of cloves.

[0009] Preferably, it comprises the following components by weight: 5 grams of Schizonepeta, 5 grams of Saposhnikovia, 5 grams of Angelica dahurica, 10 grams of Honeysuckle, 30 grams of Astragalus, 5 grams of Coptis chinensis, 10 grams of Amaranthus aquatica, 5 grams of Phellodendron chinense, 5 grams of Morus alba, 5 grams of Ginseng, 5 grams of Radix Glycyrrhizae Preparata, 5 grams of Perilla Leaf, 2 grams of Fennel, 10 grams of Dioscorea opposita and 2 grams of Clove.

[0010] Preferably, it comprises the following components by weight: 10 grams of Schizonepeta, 10 grams of Saposhnikovia, 10 grams of Angelica dahurica, 50 grams of Honeysuckle, 50 grams of Astragalus, 15 grams of Coptis chinensis, 15 grams of Amaranthus aquatica, 20 grams of Phellodendron chinense, 10 grams of Morus alba, 10 grams of Ginseng, 10 grams of Radix Glycyrrhizae Preparata, 10 grams of Perilla Leaf, 5 grams of Fennel, 30 grams of Dioscorea opposita and 5 grams of Clove.

[0011] The present invention also provides a method for preparing a Chinese medicine composition for treating allergic cough and asthma attack, which specifically comprises the following steps:

[0012] S1. Ingredient processing: using a weighing device to measure the required weight portions of schizonepeta, siler, angelica, honeysuckle, astragalus, coptis, amaranth, phellodendron, mulberry bark, ginseng, licorice, perilla leaf, fennel, yam and clove respectively;

[0013] S2, washing and draining: washing the herb Nepeta, Saposhnikovia, Angelica dahurica, Honeysuckle, Astragalus, Coptis chinensis, Atractylodes macrocephala, Phellodendron chinense, Morus alba, Ginseng, Radix Glycyrrhizae, Perilla leaf, Fennel, Dioscorea opposita and Clove weighed in step S1 for 2-3 times in sequence through a washing device, and then draining the water;

[0014] S3, boiling: pour the raw materials washed and drained in step S2 into the boiler in sequence, add water until all the raw materials are completely ground, boil over high heat, and then boil over low heat for 3-5 hours;

[0015] S4, filtering: after the simmering in step S3 is completed, the drug residue is filtered out by a filtering device, the drug liquid is collected, and then the drug liquid is filtered through a fine filtering device to completely filter out all impurities in the drug liquid;

[0016] S5, post-processing: the liquid medicine filtered in step S4 is made into a Chinese medicine product, and the finished product is made after packaging quality inspection.

[0017] Preferably, in the step S3, during the slow-cooking process, the amount of water in the boiler is controlled, and water is added every 8-12 minutes.

[0018] Preferably, the Chinese medicine product prepared in step S5 is an oral liquid, an ointment or a pill.

[0019] Preferably, the drug residue filtered out in step S4 is successively sterilized, crushed and granulated into feed to complete recycling.

[0020] (III) Beneficial effects

[0021] The present invention provides a Chinese medicine composition for treating allergic cough and asthma attack and a preparation method thereof. Compared with the prior art, the composition has the following beneficial effects:

[0022] (1) The Chinese medicine composition and preparation method for treating allergic cough and asthma attack can treat allergic cough and asthma attack more effectively through syndrome differentiation and treatment, rational preparation of Chinese medicine prescription, and optimization of combination mode. The Chinese medicine preparation can fundamentally treat allergic cough and asthma attack through oral administration, significantly improve cure rate and reduce recurrence rate. Clinically verified: the total effective rate is 98% (cure rate 70%; effective rate 28%; ineffective rate 2%).

[0023] (2) The Chinese medicine composition and preparation method for treating allergic cough and asthma attack, and the oral Chinese medicine preparation for treating allergic cough and asthma attack, have different concepts and modes of treating diseases and syndromes from Western medicine, thus avoiding the side effects caused by Western medicine, and thus have higher safety. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 The present invention is a flow chart of the preparation method. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0026] See also Figure 1 The embodiments of the present invention provide four technical solutions: a Chinese medicine composition for treating allergic cough and asthma attack and a preparation method thereof, specifically including the following embodiments:

[0027] Example 1: A Chinese medicine composition for treating allergic cough and asthma attacks, comprising the following components by weight: 7 grams of Schizonepeta, 7 grams of Saposhnikovia, 7 grams of Angelica dahurica, 30 grams of Honeysuckle, 40 grams of Astragalus, 10 grams of Coptis chinensis, 13 grams of Atractylodes macrocephala, 12 grams of Phellodendron chinense, 7 grams of Morus alba, 7 grams of Ginseng, 7 grams of Radix Glycyrrhizae Preparata, 7 grams of Perilla Leaf, 3 grams of Fennel, 20 grams of Dioscorea opposita and 3 grams of Clove.

[0028] The present invention also provides a method for preparing a Chinese medicine composition for treating allergic cough and asthma attack, which specifically comprises the following steps:

[0029] S1. Ingredient processing: using a weighing device to measure the required weight portions of schizonepeta, siler, angelica, honeysuckle, astragalus, coptis, amaranth, phellodendron, mulberry bark, ginseng, licorice, perilla leaf, fennel, yam and clove respectively;

[0030] S2, washing and draining: washing the herb Nepeta, Saposhnikovia, Angelica dahurica, Honeysuckle, Astragalus, Coptis chinensis, Atractylodes macrocephala, Phellodendron chinense, Morus alba, Ginseng, Radix Glycyrrhizae, Perilla leaf, Fennel, Dioscorea opposita and Clove weighed in step S1 twice in sequence through a washing device, and draining the water;

[0031] S3, boiling: pour the raw materials washed and drained in step S2 into the boiler in sequence, add water until all the raw materials are completely ground, boil over high heat, and then boil over low heat for 4 hours. During the low heat boiling process, control the water level in the boiler and add water every 10 minutes;

[0032] S4, filtering: after the simmering in step S3 is completed, the drug residue is filtered out by a filtering device, the drug liquid is collected, and then the drug liquid is filtered through a fine filtering device to completely filter out all impurities in the drug liquid, and the filtered drug residue is successively sterilized, crushed and granulated to make feed for recycling;

[0033] S5, post-processing: the liquid medicine filtered in step S4 is made into a Chinese medicine product, and the finished product is made into an oral liquid after passing the packaging quality inspection.

[0034] Example 2: A Chinese medicine composition for treating allergic cough and asthma attacks, comprising the following components by weight: 5 grams of Schizonepeta, 5 grams of Saposhnikovia, 5 grams of Angelica dahurica, 10 grams of Honeysuckle, 30 grams of Astragalus, 5 grams of Coptis chinensis, 10 grams of Atractylodes macrocephala, 5 grams of Phellodendron chinense, 5 grams of Morus alba, 5 grams of Ginseng, 5 grams of Radix Glycyrrhizae Preparata, 5 grams of Perilla Leaf, 2 grams of fennel, 10 grams of Dioscorea opposita and 2 grams of Clove.

[0035] The present invention also provides a method for preparing a Chinese medicine composition for treating allergic cough and asthma attack, which specifically comprises the following steps:

[0036] S1. Ingredient processing: using a weighing device to measure the required weight portions of schizonepeta, siler, angelica, honeysuckle, astragalus, coptis, amaranth, phellodendron, mulberry bark, ginseng, licorice, perilla leaf, fennel, yam and clove respectively;

[0037] S2, washing and draining: washing the herb Nepeta, Saposhnikovia, Angelica dahurica, Honeysuckle, Astragalus, Coptis chinensis, Atractylodes macrocephala, Phellodendron chinense, Morus alba, Ginseng, Radix Glycyrrhizae, Folium Perillae, Fennel, Dioscorea opposita and Clove weighed in step S1 three times in sequence through a washing device, and draining the water;

[0038] S3, boiling: pour the raw materials washed and drained in step S2 into the boiler in sequence, add water until all the raw materials are completely ground, boil over high heat, and then boil over low heat for 3 hours. During the low heat boiling process, control the amount of water in the boiler and add water every 8 minutes;

[0039] S4, filtering: after the simmering in step S3 is completed, the drug residue is filtered out by a filtering device, the drug liquid is collected, and then the drug liquid is filtered through a fine filtering device to completely filter out all impurities in the drug liquid, and the filtered drug residue is successively sterilized, crushed and granulated to make feed for recycling;

[0040] S5, post-processing: the liquid medicine filtered in step S4 is made into a Chinese medicine product, which is packaged and inspected before being made into a finished product, wherein the prepared Chinese medicine product is an ointment.

[0041] Example 3: A Chinese medicine composition for treating allergic cough and asthma attacks, comprising the following components by weight: 10 grams of Schizonepeta, 10 grams of Saposhnikovia, 10 grams of Angelica dahurica, 50 grams of Honeysuckle, 50 grams of Astragalus, 15 grams of Coptis chinensis, 15 grams of Amaranthus fruit, 20 grams of Phellodendron, 10 grams of Morus alba, 10 grams of Ginseng, 10 grams of Radix Glycyrrhizae, 10 grams of Perilla leaf, 5 grams of fennel, 30 grams of yam and 5 grams of cloves.

[0042] The present invention also provides a method for preparing a Chinese medicine composition for treating allergic cough and asthma attack, which specifically comprises the following steps:

[0043] S1. Ingredient processing: using a weighing device to measure the required weight portions of schizonepeta, siler, angelica, honeysuckle, astragalus, coptis, amaranth, phellodendron, mulberry bark, ginseng, licorice, perilla leaf, fennel, yam and clove respectively;

[0044] S2, washing and draining: washing the herb Nepeta, Saposhnikovia, Angelica dahurica, Honeysuckle, Astragalus, Coptis chinensis, Atractylodes macrocephala, Phellodendron chinense, Morus alba, Ginseng, Radix Glycyrrhizae, Perilla leaf, Fennel, Dioscorea opposita and Clove weighed in step S1 twice in sequence through a washing device, and draining the water;

[0045] S3, boiling: pour the raw materials washed and drained in step S2 into the boiler in sequence, add water until all the raw materials are completely ground, boil over high heat, and then boil over low heat for 5 hours. During the low heat boiling process, control the amount of water in the boiler and add water every 12 minutes;

[0046] S4, filtering: after the simmering in step S3 is completed, the drug residue is filtered out by a filtering device, the drug liquid is collected, and then the drug liquid is filtered through a fine filtering device to completely filter out all impurities in the drug liquid, and the filtered drug residue is successively sterilized, crushed and granulated to make feed for recycling;

[0047] S5, post-processing: the liquid medicine filtered in step S4 is made into a Chinese medicine product, which is packaged and inspected before being made into a finished product, wherein the prepared Chinese medicine product is a pill.

[0048] Embodiment 4: A Chinese medicine composition for treating allergic cough and asthma attack, characterized in that it comprises the following components by weight: 6 grams of Schizonepeta, 6 grams of Saposhnikovia, 6 grams of Angelica dahurica, 11 grams of Honeysuckle, 31 grams of Astragalus, 6 grams of Coptis chinensis, 11 grams of Atractylodes macrocephala, 6 grams of Phellodendron chinense, 6 grams of Morus alba, 6 grams of Ginseng, 6 grams of Radix Glycyrrhizae Preparata, 6 grams of Perilla Leaf, 3 grams of Fennel, 11 grams of Dioscorea opposita and 3 grams of Clove.

[0049] The present invention also provides a method for preparing a Chinese medicine composition for treating allergic cough and asthma attack, which specifically comprises the following steps:

[0050] S1. Ingredient processing: using a weighing device to measure the required weight portions of schizonepeta, siler, angelica, honeysuckle, astragalus, coptis, amaranth, phellodendron, mulberry bark, ginseng, licorice, perilla leaf, fennel, yam and clove respectively;

[0051] S2, washing and draining: washing the herb Nepeta, Saposhnikovia, Angelica dahurica, Honeysuckle, Astragalus, Coptis chinensis, Atractylodes macrocephala, Phellodendron chinense, Morus alba, Ginseng, Radix Glycyrrhizae, Folium Perillae, Fennel, Dioscorea opposita and Clove weighed in step S1 three times in sequence through a washing device, and draining the water;

[0052] S3, boiling: pour the raw materials washed and drained in step S2 into the boiler in sequence, add water until all the raw materials are completely ground, boil over high heat, and then boil over low heat for 3.5 hours. During the low heat boiling process, control the amount of water in the boiler and add water every 9 minutes;

[0053] S4, filtering: after the simmering in step S3 is completed, the drug residue is filtered out by a filtering device, the drug liquid is collected, and then the drug liquid is filtered through a fine filtering device to completely filter out all impurities in the drug liquid, and the filtered drug residue is successively sterilized, crushed and granulated to make feed for recycling;

[0054] S5, post-processing: the liquid medicine filtered in step S4 is made into a Chinese medicine product, and the finished product is made into an oral liquid after passing the packaging quality inspection.

[0055] Usage: decoction in water, 1 dose / day, taken orally in two doses, taken after meals; 14 days as a course of treatment.

[0056] It can also be boiled into ointment or pills for oral administration.

[0057] Application Examples

[0058] The Chinese medicine compositions for treating allergic cough and asthma prepared by the preparation methods of Examples 1-4 of the present invention were respectively subjected to mouse animal experiments, and the existing conventional drugs for treating allergic cough and asthma were selected as comparative examples. The mice were orally administered 1-3 ml once, 1-3 times a day, and the symptoms of the mice were observed once a week. After a course of treatment (4 weeks), the following records were made. The specific experimental results are shown in the following table:

[0059]

[0060]

[0061] It can be seen from the above table that the effect of the Chinese medicine composition for treating allergic cough and asthma attack prepared by Example 1 of the present invention is significantly better than that of Examples 2-4 and the comparative example, and the effect of the Chinese medicine composition for treating allergic cough and asthma attack prepared by Examples 1-4 of the present invention is better than that of existing drugs.

[0062] In summary, the present invention uses syndrome differentiation and treatment, rationally prepares Chinese medicine prescriptions, and optimizes the combination mode. The obtained prescription can more effectively treat allergic cough and asthma attacks. Through oral Chinese medicine preparations, allergic cough and asthma attacks can be fundamentally treated, and the cure rate is significantly improved and the recurrence rate is reduced. Clinically verified: the total effective rate is 98% (cure rate 70%; effective rate 28%; ineffective rate 2%). The oral Chinese medicine preparation treats allergic cough and asthma attacks. Its concept and mode of treating diseases and syndromes are different from Western medicine, avoiding the side effects brought by Western medicine, so it has higher safety.

[0063] Meanwhile, the contents not described in detail in this specification belong to the prior art known to those skilled in the art.

[0064] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0065] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for treating allergic cough and asthma attack, characterized in that: It includes the following components by weight: 5-10 grams of Schizonepeta, 5-10 grams of Saposhnikovia, 5-10 grams of Angelica dahurica, 10-50 grams of Honeysuckle, 30-50 grams of Astragalus, 5-15 grams of Coptis chinensis, 10-15 grams of Amaranthus fruit, 5-20 grams of Phellodendron, 5-10 grams of Morus alba, 5-10 grams of Ginseng, 5-10 grams of Radix Glycyrrhizae, 5-10 grams of Perilla leaf, 2-5 grams of fennel, 10-30 grams of Chinese yam and 2-5 grams of clove.

2. A Chinese medicine composition for treating allergic cough and asthma attack according to claim 1, characterized in that: It includes the following components by weight: 7 grams of Schizonepeta, 7 grams of Saposhnikovia, 7 grams of Angelica dahurica, 30 grams of Honeysuckle, 40 grams of Astragalus, 10 grams of Coptis chinensis, 13 grams of Amaranthus fruit, 12 grams of Phellodendron, 7 grams of Morus alba bark, 7 grams of Ginseng, 7 grams of Radix Glycyrrhizae, 7 grams of Perilla leaf, 3 grams of fennel, 20 grams of yam and 3 grams of clove.

3. A Chinese medicine composition for treating allergic cough and asthma attack according to claim 1, characterized in that: It includes the following components by weight: 5 grams of Schizonepeta, 5 grams of Saposhnikovia, 5 grams of Angelica dahurica, 10 grams of Honeysuckle, 30 grams of Astragalus, 5 grams of Coptis chinensis, 10 grams of Amaranthus aquatica, 5 grams of Phellodendron chinense, 5 grams of Morus alba, 5 grams of Ginseng, 5 grams of Radix Glycyrrhizae Preparata, 5 grams of Perilla Leaf, 2 grams of Fennel, 10 grams of Dioscorea opposita and 2 grams of Clove.

4. A Chinese medicine composition for treating allergic cough and asthma attack according to claim 1, characterized in that: It includes the following components by weight: 10 grams of Schizonepeta, 10 grams of Saposhnikovia, 10 grams of Angelica dahurica, 50 grams of Honeysuckle, 50 grams of Astragalus, 15 grams of Coptis chinensis, 15 grams of Amaranthus aquatica, 20 grams of Phellodendron chinense, 10 grams of Morus alba, 10 grams of Ginseng, 10 grams of Radix Glycyrrhizae, 10 grams of Perilla leaf, 5 grams of fennel, 30 grams of yam and 5 grams of clove.

5. A method for preparing the Chinese medicine composition for treating allergic cough and asthma attack according to any one of claims 1 to 4, characterized in that: The specific steps include: S1. Ingredient processing: using a weighing device to measure the required weight portions of schizonepeta, siler, angelica, honeysuckle, astragalus, coptis, amaranth, phellodendron, mulberry bark, ginseng, licorice, perilla leaf, fennel, yam and clove respectively; S2, washing and draining: washing the herb Nepeta, Saposhnikovia, Angelica dahurica, Honeysuckle, Astragalus, Coptis chinensis, Atractylodes macrocephala, Phellodendron chinense, Morus alba, Ginseng, Radix Glycyrrhizae, Perilla leaf, Fennel, Dioscorea opposita and Clove weighed in step S1 for 2-3 times in sequence through a washing device, and then draining the water; S3, boiling: pour the raw materials washed and drained in step S2 into the boiler in sequence, add water until all the raw materials are completely ground, boil over high heat, and then boil over low heat for 3-5 hours; S4, filtering: after the simmering in step S3 is completed, the drug residue is filtered out by a filtering device, the drug liquid is collected, and then the drug liquid is filtered through a fine filtering device to completely filter out all impurities in the drug liquid; S5, post-processing: the liquid medicine filtered in step S4 is made into a Chinese medicine product, and the finished product is made after packaging quality inspection.

6. A method for preparing a Chinese medicine composition for treating allergic cough and asthma attack according to claim 5, characterized in that: In the step S3, during the slow-cooking process, the amount of water in the boiler is controlled, and water is added every 8-12 minutes.

7. A method for preparing a Chinese medicine composition for treating allergic cough and asthma attack according to claim 5, characterized in that: The Chinese medicine product prepared in step S5 is one of oral liquid, paste or pills.

8. The method for preparing a Chinese medicine composition for treating allergic cough and asthma attack according to claim 5, characterized in that: The drug residue filtered out in step S4 is sterilized, crushed and granulated into feed in sequence to complete recycling.

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