Insecticidal composition containing methoxyfenozide

Abstract

The invention provides an insecticidal composition, the active components of the insecticidal composition comprise a first active component methoxyfenozide and a second active component acephate or quinalphos, and the weight ratio of the first active component to the second active component is 10: 1-1: 20. The weight percentage of the first active component and the second active component in the insecticidal composition is 1-90%, and the dosage forms are dispersible oil suspending agents, wettable powder, missible oil, suspending agents, microemulsion, emulsion in water, water dispersible granules and soluble powder. The insecticidal composition has a synergistic effect on insecticidal effect, can effectively delay the generation of pest resistance to drugs, can effectively reduce the cost, reduces the dosage of drugs, and protects the environment.

Description

Technical Field

[0001] The invention belongs to the technical field of pesticide compounding, and particularly relates to an insecticide composition containing methoxyfenozide. Background Art

[0002] Methoxyfenozide, commonly known as methoxyfenozide in English, is a non-steroidal molting hormone that can simulate the effects of natural insect molting hormones, causing Lepidoptera larvae to be unable to form new cuticles and molt prematurely, leading to physiological death of the larvae. Methoxyfenozide has strong selectivity and is highly effective against Lepidoptera pests. It can be used to control a wide range of Lepidoptera pests, such as armyworms, cabbage butterflies, armyworms, leaf rollers, and striped stem borers, on crops such as grains, soybeans, cotton, grapes, citrus, vegetables, corn, and ornamental plants. It has no penetration and phloem systemic activity, and is mainly effective through stomach poisoning. It also has certain contact and ovicidal activity.

[0003] Acephate, also known as acephate, has a common English name: acephate. The mechanism of action of acephate is that it can inhibit the activity of acetylcholinesterase and interfere with the motor nervous system of pests, thereby killing the pests. It is a slow-acting insecticide. Generally, the efficacy is significant 2-3 days after application. It has a wide spectrum of control and can effectively control rice planthoppers, cabbage loopers, aphids, rice leaf rollers, corn borers, mites, etc.

[0004] Quinalphos, whose common English name is quintiofos, has the mechanism of action of acetylcholinesterase inhibitor, has contact and stomach poison effects, and has strong penetration ability. It can be widely used in rice, cotton, tea, fruit trees, vegetables, etc. It is highly effective in preventing and controlling rice borers, plant hoppers, leafhoppers, cotton aphids, cotton bollworms, tea aphids, scale insects, etc.

[0005] Acephate and quinalphos are both organophosphorus insecticides, and methoxyfenozide is a dihydrazide insecticide. The applicant has found through experiments that the combination of methoxyfenozide with acephate or quinalphos has unexpected effects. Summary of the invention

[0006] The object of the present invention is to provide an insecticidal composition with reasonable components, significant synergistic effect, good insecticidal effect and low drug cost.

[0007] To achieve the above object, the technical solution of the present invention is as follows:

[0008] An insecticidal composition containing methoxyfenozide, characterized in that:

[0009] First active ingredient: methoxyfenozide;

[0010] Second active ingredient: acephate or quinalphos;

[0011] The weight ratio of the first active ingredient to the second active ingredient is 10:1 to 1:20, and the sum of their contents is 1% to 90% of the total weight of the composition.

[0012] The various application formulations prepared from the pesticide composition of the present invention include, in addition to the effective active ingredients, various auxiliary ingredients that are permitted and acceptable in different pesticide formulations.

[0013] The auxiliary ingredients include, but are not limited to, emulsifiers, dispersants, wetting agents, solvents, antifreeze agents, defoamers, thickeners, disintegrants, synergists, preservatives and fillers, etc., which are all commonly used or permitted ingredients in pesticide formulations and are not particularly limited. The specific ingredients and amounts are determined through experiments based on the formulation requirements.

[0014] The emulsifier may be any emulsifier known in the field of pesticide formulations, and may be one or more of phenylethylphenol polyoxyethylene polyoxypropylene ether, alkylaryl polyoxyethylene polyoxypropylene ether, fatty acid polyoxyethylene ether, fatty alcohol polyoxyethylene ether, glycerol laurate polyoxyethylene ether, styrylphenol polyoxyethylene ether, castor oil polyoxyethylene ether, alkylphenol polyoxypropylene polyoxyethylene ether, styrylphenyl polyoxyethylene ether, alkylphenol polyoxyethylene ether, sorbitan fatty acid ester polyoxyethylene ether, fatty alcohol polyoxyethylene ether sulfonate, alkylphenol polyoxyethylene formaldehyde condensate, calcium dodecyl sulfonate, alkylphenol polyoxyethylene ether succinic acid monoester sulfonate, alkylphenol polyoxyethylene phosphate, and alkylphenol polyoxyethylene ether sulfonated succinate.

[0015] The dispersant may be any of various dispersants known in the field of pesticide formulations, and may be one or more of alkylphenol polyoxyethylene ether phosphate, alkylphenol polyoxyethylene ether sulfate, phenethylphenol polyoxyethylene ether phosphate, polyoxyethylene polyoxypropylene ether block copolymer, sodium lignin sulfonate, sodium methylene dinaphthalene sulfonate (dispersant NNO), calcium lignin sulfonate, polycarboxylate, sodium methylene bisnaphthalene sulfonate, sodium methylene bismethylnaphthalene sulfonate, polyvinyl pyrrolidone, alkylamido taurate, sodium salt of alkylnaphthalene sulfonic acid polycondensate, and sodium methylene bisnaphthalene sulfonate formaldehyde condensate.

[0016] The wetting agent can be various wetting agents known in the field of pesticide formulations, and can be one or more of sodium alkylnaphthalene sulfonate, sodium dodecyl sulfate, sodium secondary alkyl sulfate, sodium dodecylbenzene sulfonate, fatty alcohol polyglycol ether sulfate, fatty alcohol polyoxyethylene ether, nonylphenol polyoxyethylene ether, sorbitan fatty acid ester polyoxyethylene ether, alkylnaphthalene formaldehyde condensate, alkylnaphthalene sulfonate and other wetting agents.

[0017] The solvent may be any solvent known in the field of pesticide formulations, and may be one or more of water, methanol, ethanol, N-methylpyrrolidone, N,N-dimethylformamide, N,N-dimethylacetamide, tetrahydrofurfuryl alcohol, toluene, xylene, dimethyl sulfoxide, tetrahydrofuran, cyclohexanone, n-butanol, isopropanol, solvent oil No. 100, No. 150, No. 180, and No. 200.

[0018] The antifreeze agent may be any antifreeze agent known in the field of pesticide formulations, and the antifreeze agent may be one or more of ethylene glycol, propylene glycol, glycerol, diethylene glycol, urea, and inorganic salts.

[0019] The defoamer may be any defoamer known in the field of pesticide formulations, and may be one or more of silicone compounds, epoxy soybean oil, emulsified silicone oil, and fatty alcohol.

[0020] The thickener may be any thickener known in the field of pesticide formulations, and may be one or more of xanthan gum, polyvinyl alcohol, sodium alginate, gum arabic, and magnesium aluminum silicate.

[0021] The disintegrant may be any disintegrant known in the field of pesticide formulations, and may be one or more of ammonium sulfate, sodium carboxymethyl starch, urea, low-substituted hydroxypropyl cellulose, cross-linked sodium carboxymethyl cellulose, cross-linked polyvinylpyrrolidone, sodium alginate, sodium bicarbonate, and sodium chloride.

[0022] The carrier can be various carriers known in the field of pesticide formulation, and can be one or more of glucose, white carbon black, kaolin, diatomaceous earth, light calcium carbonate, heavy calcium carbonate, attapulgite, soluble starch, urea, maltose, sucrose, citric acid, potassium carbonate, sodium carbonate, and anhydrous sodium sulfate.

[0023] The preservative may be any preservative known in the field of pesticide formulations, and the preservative may be one or more of kasone, sodium benzoate, benzoic acid, potassium sorbate, and formaldehyde.

[0024] The deionized water is industrial deionized water.

[0025] The insecticidal composition containing methoxyfenozide of the present invention can be prepared into various dosage forms permitted in agriculture with the above conventional adjuvants according to methods known to those skilled in the art.

[0026] Beneficial technical effects achieved by the present invention:

[0027] The compounding of two insecticides with different action mechanisms of the present invention firstly has an obvious synergistic effect, which can effectively reduce the amount of pesticides used and reduce costs; secondly, it can effectively delay the generation of pesticide resistance in pests and prolong the service life of the pesticides. DETAILED DESCRIPTION

[0028] The following indoor toxicity test is used to illustrate the indoor combined effect of methoxyfenozide and acephate or quinalphos against rice stem borer and rice leaf folder.

[0029] 1. Indoor combined effects of compound pesticides on rice stem borer

[0030] The test method refers to "NY / T 1154.11-2008 Pesticide Indoor Bioassay Test Guidelines Insecticide Part 11: Rice Stem Dipping Method". First, the original drug is prepared into 5 series of concentrations of solution for use. First, use scissors to cut the rice stems with consistent growth status and robustness, wash them, and cut them into a length of about 10cm. Then, immerse the prepared rice stems in the prepared solution for 30s, take them out and dry them, wrap the roots with wet absorbent cotton to keep them moist, and finally place the treated rice stems in test tubes, 3 plants per test tube, 4 replicates per treatment, and use clean water treatment as a blank control. When inoculating insects, use an insect sucker to inoculate 15 second-instar larvae of the Chilo suppressalis in each tube, and then cover the tube mouth with gauze. The treated test insects are kept and observed under the conditions of a temperature of 25±1℃, a relative humidity of about 78%, and a light cycle of L:D=(16:8)h. After 72 hours, check the death of the test insects. Taking the inability of the test insects to move as the standard, record the total number of insects and the number of dead insects, and calculate the mortality rate.

[0031] Mortality rate (%) = number of dead insects / total number of insects treated × 100

[0032] Corrected mortality rate (%) = (treatment mortality rate - blank control mortality rate) / (1 - blank control mortality rate) × 100

[0033] If the control mortality rate is less than 5%, no correction is required; if the control mortality rate is between 5% and 20%, correction is required; if the control mortality rate is greater than 20%, the test needs to be repeated. The co-toxicity coefficient method was used to evaluate the indoor combined effect of the two agents.

[0034]

[0035] Theoretical toxicity index TTI = ∑ (ATI of a drug × the percentage of the active ingredient of the drug in the mixture)

[0036]

[0037] A co-toxicity coefficient > 120 indicates a synergistic effect, a co-toxicity coefficient between 80 and 120 indicates an additive effect, and a co-toxicity coefficient < 80 indicates an antagonistic effect.

[0038] Table 1 The results of toxicity test of methoxyfenozide and acephate mixture against rice stem borer

[0039]

[0040] Table 2 The results of toxicity test of methoxyfenozide and quinalphos mixed with rice stem borer

[0041]

[0042]

[0043] 2. Combined toxicity of compound pesticides against rice leaf folder in indoor environment

[0044] The indoor toxicity test of the compound agent to rice leaf folder adopts the rice stem immersion method, which is the same as the indoor toxicity test method to Chilo suppressalis in Example 1, and will not be repeated here.

[0045] Table 3 The results of toxicity test of methoxyfenozide and acephate mixture against rice leaf folder

[0046]

[0047] Table 4 The results of toxicity test of methoxyfenozide and quinalphos mixture against rice leaf folder

[0048]

[0049]

[0050] It can be seen from the results of indoor toxicity determination in Tables 1 and 2 that when methoxyfenozide and acephate or quinalphos were mixed in a ratio of 10:1 to 1:20, they all showed a certain synergistic effect on the rice stem borer, and when the mixing ratio was 1:8 or 1:5, the synergistic effect was most obvious; it can be seen from Tables 3 and 4 that when methoxyfenozide and acephate or quinalphos were mixed in a ratio of 10:1 to 1:20, they all showed a certain synergistic effect on the rice leaf folder, and when the mixing ratio was 1:3, the synergistic effect was most obvious.

[0051] The present invention will be further described below in conjunction with the formulation examples.

[0052] Preparation Example 1

[0053] 3% of methoxyfenozide, 24% of acephate, 2% of sodium lignin sulfonate, 3% of Nongru 1601#, 4% of Span-60#, 3% of sodium alkyl sulfonate, 2% of polyvinyl alcohol, 2% of propylene glycol, and methyl oleate are added to 100% by weight. The above raw materials are mixed, dispersed at high speed shearing for 30 minutes, and sand-milled with a sand mill to obtain a 27% methoxyfenozide acephate dispersible oil suspension.

[0054] Preparation Example 2

[0055] 5% methoxyfenozide, 25% quinalphos, 5% sodium alkylnaphthalene sulfonate, 4% Span-60#, 4% Tween-60#, 4% Nongru 700#, 3% sodium naphthalene sulfonate, 1% white carbon black, 3.5% ethylene glycol, and soybean oil are added to 100% by weight. The above raw materials are mixed, dispersed at high speed shear for 30 minutes, and sand-milled with a sand mill to obtain a 30% methoxyfenozide quinalphos dispersible oil suspension.

[0056] Biological Example: Field efficacy test for controlling rice stem borer.

[0057] In 2022, a field efficacy test of methoxyfenozide combined with acephate or quinalphos to control rice stem borer was conducted in Jiangxi Province. The test treatments were the above formulation example 1, formulation example 2 and a single agent as a control agent, and the blank control was treated with clean water. The plot area is 30m 2 The plots were randomly arranged, with 3 replicates per treatment, and spraying was carried out when the eggs of the rice stem borer reached the peak hatching stage.

[0058] About 25 days after the application of the pesticide, when the damage in the control area is obvious, parallel jumping sampling is carried out at 10 points, with 5 clumps at each point, and a total of 50 clumps are surveyed in each plot. The total number of plants and the number of dead hearts are recorded. At the same time, rice is cut from the roots and the number of live insects at each point is checked. The insect control effect, dead heart rate and seedling protection effect are calculated as follows:

[0059] Insect prevention effect (%) = (number of live insects in the control area - number of live insects in the treatment area) / number of live insects in the control area × 100;

[0060] Dead core rate (%) = number of dead cores / total number of plants surveyed × 100;

[0061] Seedling protection effect (%) = [withering rate of control area - withering rate of treated area] / withering rate of control area × 100.

[0062] Table 5 Field efficacy test results of compound preparations for controlling rice stem borer

[0063]

[0064] It can be seen from the data in Table 5 that 25 days after the application, the insect control effect of each preparation was significantly higher than that of the three single preparations. From the perspective of the withered heart rate, the withered heart rate of each treatment was also significantly lower than that of the blank control. The withered heart rate after treatment with the preparation examples was also lower than that of each single preparation. From the perspective of the seedling protection effect, the seedling protection effect of each preparation example was significantly higher than that of each single preparation.

[0065] Safety investigation and observation during the trial showed that all tested agents were safe for rice growth and no pesticide damage occurred.

[0066] In summary, the composition of the present invention adopts a scheme of compounding two active ingredients, and its activity and insecticidal effect are not a simple superposition of the components. Compared with the existing single preparations, the insecticidal effect is obvious, and it has a significant synergistic effect, which meets the safety requirements of pesticide preparations. Therefore, the composition of the present invention is an ideal agent for controlling rice stem borer, and has a wide application prospect in production.

Claims

1. An insecticidal composition containing methoxyfenozide, characterized in that: The active ingredients of the insecticide composition include a first active ingredient, methoxyfenozide, and a second active ingredient, acephate or quinalphos, wherein the weight ratio of the first active ingredient to the second active ingredient is 10:1 to 1:

20.

2. The insecticidal composition containing methoxyfenozide according to claim 1, characterized in that: The weight ratio of the first active ingredient to the second active ingredient is 1:1 to 1:

15.

3. The insecticidal composition containing methoxyfenozide according to claim 1, characterized in that: The weight ratio of the first active ingredient methoxyfenozide to the second active ingredient acephate is 1:1 to 1:

10.

4. The insecticidal composition containing methoxyfenozide according to claim 1, characterized in that: The weight ratio of the first active ingredient methoxyfenozide to the second active ingredient quinalphos is 1:3 to 1:

8.

5. The insecticidal composition containing methoxyfenozide according to claim 1, characterized in that: The weight percentage of the first active ingredient and the second active ingredient in the insecticide composition is 1% to 90%.

6. The insecticidal composition containing methoxyfenozide according to claim 1, characterized in that: The insecticide composition uses the first active ingredient and the second active ingredient as main effective ingredients, and is prepared with pesticide adjuvants and excipients into any dosage form allowed in pesticides.

7. The insecticidal composition containing methoxyfenozide according to claim 1, characterized in that: The dosage form is dispersible oil suspension, wettable powder, emulsifiable concentrate, suspension, microemulsion, water emulsion, water dispersible granule, soluble powder.

8. Use of the insecticidal composition containing methoxyfenozide according to claim 1 in controlling lepidopteran pests.

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