Modified milk powder for children as well as preparation method and application of modified milk powder

Abstract

The invention provides modified milk powder for children as well as a preparation method and application thereof, and relates to the field of modified milk powder. The formula of the modified milk powder comprises skimmed milk powder, demineralized whey powder, whole milk powder, lactose, isomaltooligosacharide, crystalline fructose, vegetable oil, composite vitamins, composite minerals, calcium carbonate, choline chloride, L-carnitine, L-lysine, hydrolyzed yolk powder, soda water, lactoferrin, docosahexaenoic acid and probiotics. A finished product is obtained through the steps of burdening, shearing and filtering, homogenizing, sterilizing, concentrating, spray drying, bean jelly, dry mixing and the like. According to the modified milk powder, various trace elements can be supplemented by adding soda water; in addition, addition of soda water, hydrolyzed yolk powder or isomaltooligosacharide can promote absorption of calcium by the body and promote skeletal development of children.

Description

Technical Field

[0001] The invention belongs to the field of dairy products and relates to children's formula milk powder, and in particular to children's formula milk powder and a preparation method and application thereof. Background Art

[0002] Essential macroelements for the human body: carbon, hydrogen, oxygen, nitrogen, sulfur, phosphorus, chlorine, potassium, sodium, calcium, and magnesium; essential trace elements for the human body: iron, zinc, selenium, iodine, copper, chromium, cobalt, manganese, vanadium, fluorine, nickel, strontium, tin, molybdenum, etc. Natural soda water has excellent water quality and is weakly alkaline. The water is rich in soluble silica and a large number of trace elements, as follows: potassium 0.3-0.8mg / L, sodium 100-150mg / L, calcium 1-3mg / L, magnesium 0.1-1.0mg / L, ammonium ion 0.1-1.0mg / L, bicarbonate ion 250-350mg / L, carbonate ion 25-50mg / L, chloride ion 1-3mg / L, sulfate ion 2-6mg / L, fluoride ion 0-0.05mg / L, iron 0.01-0.10mg / L, manganese 0.01-0.10mg / L, aluminum 0.01-0.05mg / L, copper 0.001-0.01mg / L, cadmium 0. 0.002mg / L, zinc 0.001-0.005mg / L, selenium 0-0.0001mg / L, lithium 0.01-0.05mg / L, strontium 0.01-0.05mg / L, barium 0-0.05mg / L, vanadium 0-0.001mg / L, nickel 0-0.003mg / L, cobalt 0-0.005mg / L, chromium 0-0.004mg / L, antimony 0-0.00005mg / L, silver 0-0.00015mg / L, soluble silicon dioxide 5-10mg / L, silicic acid 7-12mg / L, phosphate ion 0.5-1.0mg / L, bromide 0-0.05mg / L, iodide 0-0.003mg / L. It can be seen that soda water contains almost all the mineral elements needed by the human body and can supplement a variety of trace elements.

[0003] Various elements in the body exist in a certain proportion to maintain their respective physiological functions. If the proportion is unbalanced, various diseases will occur, such as metabolic diseases, cardiovascular and cerebrovascular diseases, tumors, etc. Mineral trace elements have synergistic and antagonistic effects, and in different concentration ranges, the synergistic and antagonistic relationship is often converted to each other. The lack of one element will inevitably affect the absorption of other elements and inhibit the biological effects of other elements. (1) Synergy: Copper and iron have synergistic effects. Copper deficiency will reduce the absorption of iron and make it difficult to utilize iron. Iron deficiency will affect the absorption of zinc. Zinc can promote the absorption of iron and has a synergistic effect on blood production. It can treat anemia. Selenium and germanium have synergistic effects. Selenium and germanium can treat coronary heart disease and fight tumors. Selenium and zinc can increase the body's immune function. Cobalt has synergistic effects with zinc, copper, and manganese. Cobalt can promote the absorption of zinc. Supplementing cobalt, zinc, copper, and manganese can promote growth and development. Supplementing zinc can also increase the absorption of cobalt. Manganese can affect and improve the body's utilization of copper. Fluoride has a synergistic effect with calcium and phosphorus. Appropriate amounts of fluoride, calcium and phosphorus are beneficial to bone growth and development. Fluoride can promote the intestinal absorption of iron; vanadium can promote the effect of iron; strontium has a synergistic effect with calcium. They are all components of human bones and teeth and participate in bone growth and development metabolism. (2) Antagonism: Zinc, iron, manganese and calcium have an antagonistic effect on chromium, lead, mercury and aluminum, and can inhibit the absorption of chromium, lead, mercury and aluminum in the intestine. Selenium has an antagonistic effect with molybdenum, chromium, copper and sulfur, and selenium can reduce the toxicity of mercury, copper, thallium and arsenic.

[0004] Prior art CN111616232A provides a children's milk powder that promotes bone growth and a preparation method thereof, wherein the formula comprises raw cow's milk or raw goat's milk, skim milk powder, desalted whey powder, composite vegetable oil or 1,3 dioleyl-2-palmitoyl triglyceride, solid corn syrup, whey protein powder, crystalline fructose, oligofructose, anhydrous butter, oligogalactose, compound vitamins, compound minerals, and calcium-promoting ingredients. The invention strengthens the calcium content by adding casein phosphopeptide, hydrolyzed egg yolk powder, vitamin K2 powder and other ingredients, and can effectively improve the absorption and utilization rate of calcium, and combines various nutrients such as probiotics and dietary fiber, which can effectively promote children's bone growth, improve immunity, and meet children's growth needs. The disadvantage is that the compound mineral ingredients are complex, the dosage is large, and all substances are mixed before spray drying, which will cause a large loss of sensitive nutrients.

[0005] Prior art CN113396983A provides a kind of children's modulated milk powder rich in comprehensive nutrition and its preparation method, and its preparation raw materials include raw milk, skim milk powder, desalted whey powder, whey protein powder, complex vitamins, complex minerals, calcium carbonate, oligogalactose, oligofructose, phosphatidylserine, N-acetylneuraminic acid, yeast beta glucan, lactoferrin, vitamin K2, zeaxanthin, lutein. The children's modulated milk powder provided by the invention can play multiple functions of improving intelligence, improving immunity, protecting eyesight, promoting bone development, and promoting intestinal health in the growth and development process of children through the reasonable matching of each component. The disadvantage is that the composite mineral composition is complex, the dosage is large, and no additional probiotics are added, which limits the absorption of nutrients.

[0006] Minerals are essential for health, especially for bone health, and calcium is essential for bone health and development. Adequate mineral intake helps prevent bone-related diseases such as osteoporosis. The mineral elements compounded in milk powder according to the standard GB14880-2012 cannot meet the needs of the human body, and additional additions face the problem of too many types of additions, complex sources of compounds, and difficulty in tracing. Summary of the invention

[0007] Aiming at the problem that a large amount of minerals need to be added to the formula milk powder prepared by the prior art and that children need to absorb sufficient calcium for their growth and development, the present invention provides a children's formula milk powder and a preparation method and application thereof.

[0008] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0009] On the one hand, the present invention provides a children's formula milk powder, the formula ingredients of which include skim milk powder, desalted whey powder, whole milk powder, lactose, oligomaltose, crystalline fructose, vegetable oil, complex vitamins, complex minerals, calcium carbonate, choline chloride, L-carnitine, L-lysine, hydrolyzed egg yolk powder, lactoferrin, docosahexaenoic acid and probiotics.

[0010] Preferably, each 100 g of the multivitamin contains 300-500 μg of vitamin A, 5-10 μg of vitamin D, 2-5 mg of vitamin E, 0.5-1.0 mg of vitamin B1, 0.5-1.0 mg of vitamin B2, 0.05-0.20 mg of vitamin B6, and 100 g of vitamin B6. 12 1-2μg and vitamin C 10-20mg.

[0011] Specifically, each 100g of multivitamin contains 450μg of vitamin A, 8.2μg of vitamin D, 3.00mg of vitamin E, 0.71mg of vitamin B1, 0.85mg of vitamin B2, 0.13mg of vitamin B6, and 0.1mg of vitamin B6.12 1.61μg and vitamin C 17.5mg.

[0012] Preferably, the vegetable oil comprises one or more of corn oil, rapeseed oil, coconut oil, sunflower oil, soybean oil, walnut oil, linseed oil, and palm kernel oil, in order to provide sufficient fatty acids to meet the growth and development needs of children.

[0013] Preferably, the children's formula milk powder contains 100-500 parts of skim milk powder, 100-500 parts of desalted whey powder, 100-400 parts of whole milk powder, 50-100 parts of lactose, 30-80 parts of isomaltooligosaccharide, 20-80 parts of crystalline fructose, 50-100 parts of vegetable oil, 1-5 parts of complex vitamins, 1-5 parts of complex minerals, 2-8 parts of calcium carbonate, 0.5-1.5 parts of choline chloride, 0.05-0.15 parts of L-carnitine, 0.3-1.0 parts of L-lysine, 0.1-0.5 parts of hydrolyzed egg yolk powder, 0.1-0.5 parts of lactoferrin, 0.1-0.5 parts of docosahexaenoic acid and 0.05-0.15 parts of probiotics in the formula by weight.

[0014] Preferably, the children's formula milk powder contains 200-400 parts of skim milk powder, 200-400 parts of desalted whey powder, 150-300 parts of whole milk powder, 60-80 parts of lactose, 40-60 parts of isomaltooligosaccharide, 30-50 parts of crystalline fructose, 60-80 parts of vegetable oil, 1.5-3.0 parts of complex vitamins, 1.5-3.0 parts of complex minerals, 4-6 parts of calcium carbonate, 0.8-1.2 parts of choline chloride, 0.06-0.10 parts of L-carnitine, 0.4-0.8 parts of L-lysine, 0.1-0.3 parts of hydrolyzed egg yolk powder, 0.1-0.3 parts of lactoferrin, 0.2-0.4 parts of docosahexaenoic acid and 0.08-0.12 parts of probiotics in the formula by weight.

[0015] Specifically, the children's formula milk powder contains 300kg of skim milk powder, 250kg of desalted whey powder, 206.06kg of whole milk powder, 70kg of lactose, 55kg of isomaltooligosaccharide, 40kg of crystalline fructose, 70kg of vegetable oil, 2kg of complex vitamins, 2kg of complex minerals, 5kg of calcium carbonate, 1kg of choline chloride, 0.08kg of L-carnitine, 0.6kg of L-lysine, 0.2kg of hydrolyzed egg yolk powder, 0.2kg of lactoferrin, 0.3kg of docosahexaenoic acid and 0.1kg of probiotics per ton.

[0016] Skim milk powder, desalted whey powder and whole milk powder are the main ingredients of formula milk powder and provide the main nutrients.

[0017] The protein and carbohydrate content of skim milk powder is higher than that of whole milk powder, and the calories of skim milk powder are relatively low.

[0018] Desalted whey powder refers to the whey powder made by removing the mineral salts from pasteurized fresh whey without any preservatives through physical separation technology (electrodialysis, ion exchange), low-temperature concentration and spray drying. Adding desalted whey powder to milk powder can adjust the protein ratio to make it closer to the protein ratio in breast milk, which is more suitable for the growth and development of children.

[0019] Lactose is a disaccharide, which is composed of glucose and galactose connected by 1,4-glycosidic bonds; lactose is not digested and absorbed in the human stomach and can directly reach the intestines. In the human intestine, lactose is broken down into glucose and galactose and is easily absorbed. Galactose is a component of glycolipids that constitute the brain and nerve tissues. It is very important for the intellectual development of infants. It can promote the production of galactocerebrosides and mucopolysaccharides. Lactose can promote the production of certain lactic acid bacteria in the human intestine, inhibit the growth of spoilage bacteria, and help the peristalsis of the intestine. Since the production of lactic acid is conducive to the absorption of calcium and other substances, it can prevent the occurrence of rickets. Lactose is often fortified in baby food.

[0020] Isomaltooligosaccharide is a functional oligosaccharide that is not absorbed by the digestive enzymes in the human body. It is preferentially used by bifidobacteria in the intestines to help them multiply in large quantities. It is a bifidobacterium proliferation factor. Other harmful bacteria in the intestines cannot use isomaltooligosaccharide, which can inhibit the growth of harmful bacteria, maintain the balance of intestinal flora, and thus promote food digestion and absorption, and improve immunity. Bifidobacteria also promote the absorption of mineral elements. Some studies have shown that isomaltooligosaccharide is not digested and absorbed by the human body, but converted into L-lactic acid in the intestines. L-lactic acid absorbs calcium compounds to increase its solubility, thereby enhancing calcium absorption capacity.

[0021] Crystalline fructose is a monosaccharide, an isomer of glucose, containing 6 carbon atoms, with a molecular formula of C6H 12 O6, with a sweetness 1.2-1.8 times that of sucrose, exists naturally in the juice of fruits, honey and grains. Crystalline fructose has a fruity aroma, low calorific value, and is metabolized faster in the body than glucose. It is easily absorbed and utilized by the body, does not rely on insulin, and has a small blood sugar burden. Fructose can promote the growth and reproduction of beneficial bacteria such as bifidobacteria in the human body, inhibit the growth of harmful bacteria, improve gastrointestinal function and metabolism, reduce blood lipids, and does not cause tooth decay. It is an ideal sweetener for diabetics, obese patients, and children.

[0022] The role of calcium carbonate is to strengthen the calcium content; compared with other calcium sources, calcium carbonate contains 40% calcium and has an absorption rate of 39%. At the same time, calcium carbonate is easily dissolved in the stomach acid environment and forms calcium ions, which are more easily used by the body.

[0023] Choline is an essential nutrient for the human body. In the human body, choline chloride can regulate fat metabolism, prevent liver deposition and degeneration, promote the formation of amino acids, and improve the body's utilization of amino acids.

[0024] L-carnitine is an amino acid-like nutrient that helps transport fatty acids to mitochondria for oxidative decomposition, promotes fat metabolism, improves fat utilization, meets children's energy needs, and supports their growth and development.

[0025] As one of the essential amino acids for children's growth and development, L-lysine participates in the synthesis of various proteins such as skeletal muscle, enzymes, serum proteins, polypeptide hormones, etc. in the body, stimulates the secretion of growth hormone, and can also chelate with mineral elements such as calcium and iron to form soluble small molecule monomers, promote the absorption of these mineral elements, and thus promote the growth and development of the body. In addition, it is also an important component of muscle tissue, helping muscle cells to synthesize protein and maintain the health of muscles. L-lysine can also increase the activity and number of immune cells, enhance the function of the immune system, and reduce the occurrence of diseases. By extending the life of vascular endothelial cells and inhibiting the activity of angiotensin converting enzyme, L-lysine can also lower blood pressure and prevent the occurrence of cardiovascular diseases such as hypertension. At the same time, it can also improve anemia symptoms by promoting the absorption and utilization of iron and stimulating erythrogenesis. In addition, L-lysine can promote liver detoxification, prevent liver damage, improve gastrointestinal function, and promote appetite and digestion.

[0026] Hydrolyzed egg yolk powder is a new resource food. It is a functional substance extracted from egg yolk. It belongs to small molecule active polypeptide and is the most easily absorbed protein form by human body. It is made of egg yolk as raw material, and is produced by protease treatment, heating, centrifugal separation, spray drying and other steps. It is easy to blend with milk. It can increase the number of osteoblasts and promote the formation of bones and teeth; activate the original power of bones and promote the elongation of bones; promote the calcium deposition of bones and strengthen the toughness of bones; inhibit the growth of osteoclasts and maintain the balance of bone components. Its mechanism of action is as follows: hydrolyzed egg yolk powder promotes the production of bone growth factors (such as IGF1 and TGFβ1) by stimulating bone bud cells, thereby promoting bone growth; in addition, hydrolyzed egg yolk powder can also inhibit the secretion of osteoclast cell division factors (such as IL-1, IL-6, TNFα) to maintain the balance of bone components; at the same time, hydrolyzed egg yolk powder can promote calcium absorption and inhibit excessive calcium loss, thereby promoting bone growth and health.

[0027] In another aspect, the present invention provides a method for preparing a modulated milk powder, comprising the following steps:

[0028] S1, standardized proportioning process: skim milk powder, desalted whey powder, whole milk powder, lactose, isomaltooligosaccharide, crystalline fructose, vegetable oil, complex vitamins, complex minerals, calcium carbonate, choline chloride, L-carnitine, L-lysine and hydrolyzed egg yolk powder are mixed to obtain material C1, and material C1 is uniformly mixed with water in proportion to obtain material C2;

[0029] S2, shearing and filtering: pour the material C2 obtained in S1 into the high-speed shear tank and stir for 10 minutes;

[0030] S3, homogenization: homogenize the material obtained in S2, under the condition of temperature of 60°C and pressure of 15MPa;

[0031] S4, sterilization: sterilize the material obtained in S3 at 90°C for 30 seconds;

[0032] S5, concentration: concentrate the material obtained in S4 to 20° Bé, under the conditions of vacuum degree -20 kPa and temperature of 60°C;

[0033] S6, spray drying: spray drying the material obtained in S5, under the following conditions: pressure of 18 MPa, inlet air temperature of 180°C and exhaust air temperature of 80°C;

[0034] S7, jelly: cool the material obtained in step S6 to room temperature through a fluidized bed, the water content of the material is 3%, and the temperature of the milk powder at the fluidized bed outlet should be maintained at 30°C;

[0035] S8, dry mixing: adding auxiliary materials to the material obtained in S7, and then mixing evenly in a spiral mixer to obtain formula milk powder.

[0036] Preferably, the water used in step S1 is soda water, which contains 0.3-0.8 mg / L potassium, 100-150 mg / L sodium, 1-3 mg / L calcium, 0.1-1.0 mg / L magnesium, 0.1-1.0 mg / L ammonium ions, 250-350 mg / L bicarbonate ions, 25-50 mg / L carbonate ions, 1-3 mg / L chloride ions, 2-6 mg / L sulfate ions, 0-0.05 mg / L fluoride ions, 0.01-0.10 mg / L iron, 0.01-0.10 mg / L manganese, 0.01-0.10 mg / L aluminum, 0.01-0.05 mg / L copper, 0.001-0.01 mg / L cadmium, 0.002 mg / L L, zinc 0.001-0.005mg / L, selenium 0-0.0001mg / L, lithium 0.01-0.05mg / L, strontium 0.01-0.05mg / L, barium 0-0.05mg / L, vanadium 0-0.001mg / L, nickel 0-0.003mg / L, cobalt 0-0.005mg / L, chromium 0-0.004mg / L, antimony 0-0.00005mg / L, silver 0-0.00015mg / L, soluble silica 5-10mg / L, silicic acid 7-12mg / L, phosphate ion 0.5-1.0mg / L, bromide 0-0.05mg / L and iodide 0-0.003mg / L, pH 9.0.

[0037] Preferably, in step S1, the mass ratio of material C1 to soda water is 1:2-1:5.

[0038] Specifically, in step S1, the mass ratio of material C1 to soda water is 1:3.

[0039] Specifically, the soda water is natural drinking soda water from Keshan County.

[0040] Lactoferrin is a protein with immune regulatory functions such as antibacterial, antiviral, and anti-oxidative damage. At the same time, lactoferrin is also a multi-functional glycoprotein in iron transporter.

[0041] Docosahexaenoic acid (DHA) is a major nutrient for the growth and maintenance of nervous system cells and an important component of the brain and retina. Its content in the human cerebral cortex is as high as 20%, and its largest proportion in the retina of the eye is about 50%. It is essential for the development of intelligence and vision.

[0042] Probiotics are a type of active microorganisms that are beneficial to the host, can improve the host's microecological balance and play a beneficial role. The beneficial bacteria or fungi in the human intestine mainly include Clostridium butyricum, Lactobacillus, Bifidobacterium, Actinomycetes, yeast, etc., which have the effects of preventing constipation, improving intestinal function, helping digestion and absorption of nutrients, and producing important nutrients.

[0043] Preferably, the auxiliary materials in step S8 include lactoferrin, docosahexaenoic acid and probiotics.

[0044] Preferably, the probiotics include one or more of Lactobacillus plantarum, Lactobacillus mucilaginosus fermentans, Lactobacillus acidophilus, Lactobacillus mucilaginosus reuteri, Lactobacillus rhamnosus, and Pediococcus acidilactici.

[0045] Preferably, the formula milk powder contains 0.1-0.5 kg of lactoferrin, 0.1-0.5 kg of docosahexaenoic acid and 0.05-0.15 kg of probiotics per ton.

[0046] Preferably, the modulated milk powder contains 0.1-0.3 kg of lactoferrin, 0.2-0.4 kg of docosahexaenoic acid and 0.08-0.12 kg of probiotics per ton.

[0047] Specifically, the formula milk powder contains 0.2 kg of lactoferrin, 0.3 kg of docosahexaenoic acid and 0.1 kg of probiotics per ton.

[0048] Specifically, the probiotic is Lactobacillus plantarum, and the number of viable bacteria is 4×10 10 CFU / g.

[0049] Lactoferrin, docosahexaenoic acid and probiotics are all sensitive substances. Various conventional treatments in dairy processing, such as heating, stirring, spraying, etc., will cause more or less loss of these substances. Adding these auxiliary materials after the main ingredients are spray-dried can avoid the loss caused by wet processing technology.

[0050] On the other hand, the present invention provides the use of the modulated milk powder in promoting the body to absorb calcium.

[0051] Specifically, replacing ordinary drinking water with Keshan County natural soda water to prepare milk powder can reduce the addition of additional minerals, while also significantly promoting the body's absorption of calcium.

[0052] Compared with the prior art, the present invention has the following beneficial effects:

[0053] 1. Keshan County's natural drinking soda water is rich in minerals. Adding this soda water to the formula milk powder can partially meet the mineral needs of the formula milk powder, supplement a variety of trace elements, and reduce the types of additional added minerals;

[0054] 2. The rich trace mineral elements in the modulated milk powder prepared with soda water have a synergistic effect, which improves the body's absorption of calcium, increases the bone calcium content, and helps children's bone growth and development;

[0055] 3. Adding isomaltooligosaccharide and hydrolyzed egg yolk powder to the formula milk powder prepared with soda water helps the absorption of calcium. DETAILED DESCRIPTION

[0056] The sources of the key raw materials used in the present invention are as follows. Raw materials not specifically described are all common commercially available products and are not specifically limited.

[0057] Skim milk powder: purchased from Westland, model 2417;

[0058] Demineralized whey powder: purchased from Euroserum, model D90;

[0059] Whole milk powder: purchased from Youbeikang Dairy Co., Ltd., CAS number 94353-35-6;

[0060] Isomaltooligosaccharide: purchased from Baolingbao Biotechnology Co., Ltd., model IMO-50;

[0061] Hydrolyzed egg yolk powder: purchased from Fufeng SNT Biotech Co., Ltd., product number SNT200506;

[0062] Casein hydrolyzed peptide: purchased from Hebei Yulongxiang Biotechnology Co., Ltd., CAS No. 142211-96-9;

[0063] Fish collagen peptide: purchased from Shandong Gushuo Biotechnology Co., Ltd., CAS No. 9064-67-9.

[0064] Example 1: Detection of trace elements in water

[0065] Tests were conducted on natural soda water and ordinary drinking water in Keshan County. The ingredients in natural soda water in Keshan County were tested with reference to the "GB 8538 National Food Safety Standard Test Method for Drinking Natural Mineral Water", and the test results are as follows: potassium 0.51mg / L, sodium 127.40mg / L, calcium 2.02mg / L, magnesium 0.61mg / L, ammonium ion 0.54mg / L, bicarbonate ion 292.52mg / L, carbonate ion 33.67mg / L, chloride ion 2.62mg / L, sulfate ion 4.50mg / L, fluoride ion <0.05mg / L, iron 0.068mg / L, manganese 0.059mg / L, aluminum 0.035mg / L, copper <0.008mg / L , cadmium <0.002mg / L, zinc 0.0034mg / L, selenium <0.0001mg / L, lithium 0.047mg / L, strontium <0.05mg / L, barium 0.0424mg / L, vanadium 0.0009mg / L, nickel 0.0022mg / L, cobalt <0.005mg / L, chromium <0.004mg / L, antimony <0.00005mg / L, silver <0.00014mg / L, soluble silicon dioxide 7.62mg / L, silicic acid 9.91mg / L, phosphate ion 0.869mg / L, bromide <0.05mg / L and iodide 0.002mg / L. The ingredients of ordinary drinking water shall comply with GB 5749-2022 Drinking Water Hygiene Standard.

[0067] Example 2: A method for preparing a modulated milk powder

[0068] According to the formula of the modulated milk powder in Table 1, each substance was weighed, wherein each 100g of the compound vitamin contained 450μg of vitamin A, 8.2μg of vitamin D, 3.00mg of vitamin E, 0.71mg of vitamin B1, 0.85mg of vitamin B2, 0.13mg of vitamin B6, and 1.3mg of vitamin B6. 12 1.61μg, vitamin C 17.5mg; complex minerals contain sodium 390mg, magnesium 40mg, calcium 1000mg, iron 8.0mg, zinc 6.25mg and selenium 8.0μg per 100g.

[0069] Table 1 Formula of Modulated Milk Powder

[0070] Raw material or ingredient name Ton of powder consumption (kg) Skim milk powder 300 Demineralized whey powder 250 Whole milk powder 206.06 lactose 70 Isomaltooligosaccharide 55 Crystalline fructose 40 Vegetable oil 70 Multivitamins 2 Complex minerals 2 Calcium carbonate 5 Choline chloride 1 L-Carnitine 0.08 L-Lysine 0.6 Hydrolyzed Egg Yolk Powder 0.2

[0071] After weighing the above substances, proceed as follows:

[0072] S1. Standardized proportioning process: after mixing the above substances, add 3 times the weight of Keshan County drinking natural soda water and mix evenly;

[0073] S2, shearing and filtering: pour the material in S1 into the high-speed shear tank and stir for 10 minutes;

[0074] S3, homogenization: homogenize the material in S2 at a temperature of 60°C and a pressure of 15MPa;

[0075] S4, sterilization: sterilize the materials in S3 at 90°C for 30 seconds;

[0076] S5, concentration: concentrate the material in S4 to 20°Bé, concentration conditions: vacuum degree -20kPa and temperature 60°C;

[0077] S6, spray drying: spray drying the material in S5, under the following conditions: pressure of 18 MPa, inlet air temperature of 180°C and exhaust air temperature of 80°C;

[0078] S7, jelly: cool the material in S6 to room temperature through a fluidized bed, the water content of the material is 3%, and the temperature of the milk powder at the outlet of the fluidized bed should be maintained at 30°C to obtain base powder;

[0079] S8, dry mixing: add lactoferrin, DHA and probiotics and other auxiliary materials to the base powder according to the formula in Table 2 in a spiral mixer, and mix evenly to obtain formula milk powder. The probiotics are plant lactobacillus, and the number of viable bacteria is 4×10 10 CFU / g.

[0080] Table 2 Excipients formula

[0081] Raw material or ingredient name Ton of powder consumption (kg) Base powder 999.5 Lactoferrin 0.2 Docosahexaenoic acid oil (DHA 35%) 0.3 Probiotics 0.1

[0082] Example 3: Detection of mineral elements in milk powder

[0083] 1) Preparation of Modulated Milk Powder

[0084] Experimental group: prepared according to the scheme of Example 2;

[0085] Control group: ordinary drinking water was used instead of soda water, and the rest was the same as in Example 2.

[0086] 2) Detection of mineral elements

[0087] With reference to "GB5009.268-2016 National Food Safety Standard Determination of Multiple Elements in Food Method 1", the contents of calcium, iron, zinc, selenium, copper, chromium, cobalt, manganese, vanadium, nickel, strontium, tin and molybdenum in milk powder were determined; with reference to "GB5009.267-2020 National Food Safety Standard Determination of Iodine in Food", the iodine content in milk powder was determined; with reference to "GB / T5009.18-2003 Determination of Fluoride in Food", the fluorine content in milk powder was determined.

[0088] 3) Results

[0089] As shown in Table 3, compared with the control group, the calcium content in the formula milk powder prepared by using natural drinking soda water in Keshan County is not much different, but the trace elements in the milk powder are richer, among which the strontium content can reach 0.2 mg / kg. Strontium has the effects of promoting metabolism, anti-oxidation, regulating blood pressure, softening blood vessels, etc. In addition, strontium is a normal component of human bones and teeth, and can promote bone development and the formation of ribs.

[0090] Table 3 Comparison of mineral element content in modulated milk powder prepared from natural soda water and ordinary drinking water

[0091]

[0092]

[0093] Example 4: Preparation of different modulated milk powders

[0094] Prepare 8 different kinds of modulated milk powder according to the following requirements:

[0095] Soda water group 1: prepared according to the technical scheme of Example 2 of this patent;

[0096] Soda water group 2: isomaltooligosaccharide was replaced with an equal amount of stachyose, and the rest was the same as in Example 2;

[0097] Soda water group 3: hydrolyzed egg yolk powder was replaced with an equal amount of casein hydrolyzed peptides, and the rest was the same as in Example 2;

[0098] Soda water group 4: hydrolyzed egg yolk powder was replaced with an equal amount of fish collagen peptide, and the rest was the same as in Example 2;

[0099] Ordinary drinking water group 1: drinking water was used instead of Keshan County drinking natural soda water, and the rest was the same as Example 2;

[0100] Normal drinking water group 2: isomaltooligosaccharide was replaced with an equal amount of stachyose, and the rest was the same as normal drinking water group 1;

[0101] Normal drinking water group 3: hydrolyzed egg yolk powder was replaced with an equal amount of casein hydrolyzed peptides, and the rest was the same as normal drinking water group 1;

[0102] Ordinary drinking water group 4: hydrolyzed egg yolk powder was replaced with an equal amount of fish collagen peptide, and the rest was the same as ordinary drinking water group 1.

[0103] Example 5: Calcium absorption in mouse bones

[0104] 40 SPF SD female rats, weighing 250-320g, were randomly divided into 8 groups, 5 rats in each group, and each group was gavaged with 8 different modulated milk powders in Example 4, with a gavage dosage of 2g / kg, 3 times a day, for 90 consecutive days. After the experiment, the femur calcium content was determined by atomic absorption spectrophotometry (GB / T5009.92), and the results are shown in Table 4.

[0105] The soda water group was higher than the ordinary drinking water group, indicating that the rich variety of trace mineral elements in the modulated milk powder prepared by soda water played a synergistic role, ultimately improving the body's absorption of calcium, thereby increasing the bone calcium content, which is conducive to bone growth and development. In soda water groups 1-4, it was found that after oligosaccharides were replaced with an equal amount of stachyose; hydrolyzed egg yolk powder was replaced with an equal amount of casein hydrolyzed peptides or an equal amount of fish collagen peptides, the bone calcium content decreased to varying degrees, indicating that adding oligosaccharides and hydrolyzed egg yolk powder to the modulated milk powder prepared with soda water can help improve the effect of calcium absorption. However, no such difference was found in the bone calcium content of each group in the ordinary drinking water groups 1-4, indicating that this improvement effect is related to the addition of soda water.

[0106] Table 4 Effects of different formula milk powders on bone calcium content in mice

[0107] Water use Group Bone calcium content (mg / g) Soda water group 1 Prepared according to the technical solution of this patent <![CDATA[228.545±3.099 a ]]> Soda water set 2 Isomaltooligosaccharide was replaced with an equal amount of stachyose <![CDATA[220.829±3.104 ab ]]> Soda water group 3 Hydrolyzed egg yolk powder is replaced with an equal amount of casein hydrolyzed peptides <![CDATA[216.293±2.948 b ]]> Soda water group 4 Hydrolyzed egg yolk powder is replaced with an equal amount of fish collagen peptides <![CDATA[215.987±2.481 b ]]> Ordinary drinking water group 1 Using drinking water instead of natural soda water in Keshan County <![CDATA[203.032±3.148 c ]]> Ordinary drinking water group 2 Isomaltooligosaccharide was replaced with an equal amount of stachyose <![CDATA[201.035±2.425 c ]]> Ordinary drinking water group 3 Hydrolyzed egg yolk powder is replaced with an equal amount of casein hydrolyzed peptides <![CDATA[200.392±2.342 c ]]> Ordinary drinking water group 4 Hydrolyzed egg yolk powder is replaced with an equal amount of fish collagen peptides <![CDATA[205.749±1.385 c ]]>

[0108] Note: Different letters indicate significant differences, p < 0.05.

[0109] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. A children's formula milk powder, characterized in that: The formula contains skimmed milk powder, demineralized whey powder, whole milk powder, lactose, isomaltooligosaccharide, crystalline fructose, vegetable oil, multivitamins, multiminerals, calcium carbonate, choline chloride, L-carnitine, L-lysine, hydrolyzed egg yolk powder, lactoferrin, docosahexaenoic acid, probiotics and soda water.

2. The formula milk powder according to claim 1, characterized in that: The multivitamin contains 300-500 μg of vitamin A, 5-10 μg of vitamin D, 2-5 mg of vitamin E, 0.5-1.0 mg of vitamin B1, 0.5-1.0 mg of vitamin B2, 0.05-0.20 mg of vitamin B6, and 100 g of vitamin B6. 12 1-2μg and vitamin C 10-20mg.

3. The formula milk powder according to claim 1, characterized in that: The complex minerals contain 390 mg of sodium, 40 mg of magnesium, 1000 mg of calcium, 8.0 mg of iron, 6.25 mg of zinc, and 8.0 μg of selenium per 100 g.

4. The modulated milk powder according to any one of claims 1 to 3, characterized in that The formula contains 100-500 parts of skimmed milk powder, 100-500 parts of desalted whey powder, 100-400 parts of whole milk powder, 50-100 parts of lactose, 30-80 parts of isomaltooligosaccharide, 20-80 parts of crystalline fructose, 50-100 parts of vegetable oil, 1-5 parts of complex vitamins, 1-5 parts of complex minerals, 2-8 parts of calcium carbonate, 0.5-1.5 parts of choline chloride, 0.05-0.15 parts of L-carnitine, 0.3-1.0 parts of L-lysine, 0.1-0.5 parts of hydrolyzed egg yolk powder, 0.1-0.5 parts of lactoferrin, 0.1-0.5 parts of docosahexaenoic acid and 0.05-0.15 parts of probiotics by weight.

5. The formula milk powder according to claim 4, characterized in that: The formula contains 200-400 parts of skimmed milk powder, 200-400 parts of desalted whey powder, 150-300 parts of whole milk powder, 60-80 parts of lactose, 40-60 parts of isomaltooligosaccharide, 30-50 parts of crystalline fructose, 60-80 parts of vegetable oil, 1.5-3.0 parts of complex vitamins, 1.5-3.0 parts of complex minerals, 4-6 parts of calcium carbonate, 0.8-1.2 parts of choline chloride, 0.06-0.10 parts of L-carnitine, 0.4-0.8 parts of L-lysine, 0.1-0.3 parts of hydrolyzed egg yolk powder, 0.1-0.3 parts of lactoferrin, 0.2-0.4 parts of docosahexaenoic acid and 0.08-0.12 parts of probiotics.

6. A method for preparing a modulated milk powder according to any one of claims 1 to 5, characterized in that: The following steps are involved: S1, standardized proportioning process: skim milk powder, desalted whey powder, whole milk powder, lactose, isomaltooligosaccharide, crystalline fructose, vegetable oil, complex vitamins, complex minerals, calcium carbonate, choline chloride, L-carnitine, L-lysine and hydrolyzed egg yolk powder are mixed to obtain material C1, and material C1 is uniformly mixed with water in proportion to obtain material C2; S2, shearing and filtering: shearing and filtering the material C2 obtained in S1; S3, homogenization: homogenize the material obtained in S2; S4, sterilization: sterilize the material obtained in S3; S5, concentration: concentrating the material obtained in S4; S6, spray drying: spray drying the material obtained in S5; S7, jelly: cooling the material obtained in step S6; S8, dry mixing: adding auxiliary materials to the material obtained in S7, and mixing evenly to obtain formula milk powder.

7. The preparation method according to claim 6, characterized in that: The water used in step S1 is soda water, which contains 0.3-0.8 mg / L potassium, 100-150 mg / L sodium, 1-3 mg / L calcium, 0.1-1.0 mg / L magnesium, 0.1-1.0 mg / L ammonium ions, 250-350 mg / L bicarbonate ions, 25-50 mg / L carbonate ions, 1-3 mg / L chloride ions, 2-6 mg / L sulfate ions, 0-0.05 mg / L fluoride ions, 0.01-0.10 mg / L iron, 0.01-0.10 mg / L manganese, 0.01-0.10 mg / L aluminum, 0.01-0.05 mg / L copper, 0.001-0.01 mg / L cadmium, 0.002 mg / L Zinc 0.001-0.005mg / L, selenium 0-0.0001mg / L, lithium 0.01-0.05mg / L, strontium 0.01-0.05mg / L, barium 0-0.05mg / L, vanadium 0-0.001mg / L, nickel 0-0.003mg / L, cobalt 0-0.005mg / L, chromium 0-0.004mg / L, antimony 0-0.00005mg / L, silver 0-0.00015mg / L, soluble silica 5-10mg / L, silicic acid 7-12mg / L, phosphate ion 0.5-1.0mg / L, bromide 0-0.05mg / L and iodide 0-0.003mg / L, pH 9.

0.

8. The preparation method according to claim 6 or 7, characterized in that: The mass ratio of the material C1 to the soda water is 1:2-1:5, and the soda water is natural drinking soda water from Keshan County.

9. The preparation method according to claim 6, characterized in that: The auxiliary materials in step S8 include lactoferrin, docosahexaenoic acid and probiotics.

10. Use of the modulated milk powder according to any one of claims 1 to 5 in promoting bone development in children.

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