Oral care solution with effect of improving oral health and preparation method of oral care solution

Abstract

The invention relates to an oral care solution with an effect of improving oral health and a preparation method of the oral care solution. The preparation method comprises the following steps: adding creatine, guaiazulene sodium sulfonate, cetylpyridinium chloride, phyllanthus emblica fruit extract and auxiliary materials into water, and uniformly stirring and dissolving; and adding a pH regulator into the obtained solution, and regulating the pH value to 7.0-9.0 to obtain the oral care solution with the effect of improving the oral health. The cetylpyridinium chloride is added, and the pH value of the product is adjusted to 7.0-9.0, so that the stability of the guaiazulene sodium sulfonate in the product is improved, and the efficacy of the product within the shelf life of the product is ensured. In addition, the functional components such as the guaiazulene sodium sulfonate, the creatine and the phyllanthus emblica fruit extract are mainly added into the oral care solution, so that the oral care solution has multiple effects of improving oral mucosa health, oral ulcer, gingival inflammation, halitosis and xerostomia, preventing decayed teeth and the like.

Description

Technical Field

[0001] The invention relates to the technical field of oral care products, and in particular to an oral care liquid having the effect of improving oral health and a preparation method thereof. Background Art

[0002] Oral diseases are common and frequently occurring diseases that affect human health. Common oral diseases include caries, gingivitis, periodontal disease, dentin hypersensitivity, oral ulcers, halitosis and xerostomia. The harmfulness of chronic non-communicable diseases to human health has aroused human concern, and the prevention and treatment of oral diseases is one of the important topics of future life science research.

[0003] There are many kinds of oral care liquids (mouthwash, mouth spray, gargle, etc.) on the market, but most of them have relatively simple functions, basically focusing on freshening breath and preventing tooth decay, and cannot truly solve consumers' oral health problems.

[0004] Sodium guaiacyl sulfonate, derived from chamomile and other Asteraceae plants, is a derivative of sesquiterpenoid azulene compounds. It has anti-inflammatory effects, promotes ulcer healing, and promotes granulation tissue regeneration. It is often used in oral care products and has the effects of oral mucosal repair and gum care and repair. However, the chemical properties of sodium guaiacyl sulfonate are unstable, especially when it is decomposed by light, which leads to problems such as product discoloration and weakened efficacy.

[0005] Creatine exists naturally in the human body and is an amino acid derivative. Creatine strengthens the cell defense mechanism by increasing cell energy reserves, protecting the cell membrane from stress, relieving irritation, and protecting the oral mucosa. Creatine can bind to the moisture in the oral mucosa, lock in moisture and improve dry mouth.

[0006] Emblica fruit extract is a plant extract that can reduce harmful oral bacteria such as Fusobacterium nucleatum, Porphyromonas gingivalis, and Clostridium morel, and can reduce gingival inflammation and improve bad breath.

[0007] Therefore, in view of the shortage of multi-functional oral care solutions in the market, there is an urgent need to provide a new type of oral care solution that can improve oral health. Summary of the invention

[0008] In order to solve the above technical problems, the present invention provides an oral care liquid with the effect of improving oral health and a preparation method thereof. The present invention adds various functional ingredients to make the oral care liquid have multiple functions such as improving oral mucosal health, improving oral ulcers, alleviating gingival inflammation, improving halitosis, improving dry mouth, and preventing dental caries. The main functional ingredients are sodium guaiacyl sulfonate, creatine, and emblica fruit extract.

[0009] The invention not only reduces harmful oral bacteria but also improves the stability of sodium guaiacyl sulfonate by adding cetylpyridinium chloride, a cationic surfactant; and improves the stability of sodium guaiacyl sulfonate by adjusting the pH value of the product to 7.0-9.0, preferably 8.0-9.0, thereby ensuring the efficacy of the oral care solution within the shelf life.

[0010] The present invention is achieved through the following technical solutions:

[0011] The first object of the present invention is to provide an oral care solution having the effect of improving oral health, which comprises the following components by mass percentage:

[0012] Sodium guaiacyl sulfonate: 0.01%-0.1%, creatine: 0.1%-1.4%, emblica fruit extract: 0.1%-1%, cetylpyridinium chloride: 0.05%-0.1%, pH adjuster: 0.05%-1%, moisturizer: 5%-30%, sweetener: 0%-0.05%, flavor and fragrance: 0.1%-1%, anti-caries agent: 0.05%-5%, solubilizer: 0.5%-6%, preservative: 0.1%-1%, other effective ingredients: 0%-5%, pigment: 0%-0.01%, and the balance is water; the pH value of the oral care solution is 7.0-9.0; preferably 8.0-9.0.

[0013] In one embodiment of the present invention, the pH adjuster is selected from one or more of sodium citrate, sodium tripolyphosphate, sodium bicarbonate, sodium hydroxide, disodium hydrogen phosphate, sodium pyrophosphate, sodium phosphate and citric acid-sodium citrate buffer.

[0014] In one embodiment of the present invention, the humectant is selected from one or more of sorbitol, glycerol, propylene glycol, xylitol, and polyethylene glycol.

[0015] In one embodiment of the present invention, the sweetener is selected from one or more of saccharin sodium, sucralose and stevioside;

[0016] And / or, the flavor and fragrance is selected from one or more of flavor, menthol, menthone glycerol ketal, WS-3 and WS-23.

[0017] In one embodiment of the present invention, the anticaries agent is selected from one or more of sodium fluoride, sodium monofluorophosphate and xylitol.

[0018] In one embodiment of the present invention, the solubilizing agent is selected from one or more of poloxamer 407, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil and Tween-20.

[0019] In one embodiment of the present invention, the preservative is selected from one or more of potassium sorbate, methylparaben, propylparaben, phenoxyethanol, caprylyl glycol / 1,2-hexanediol and cymene.

[0020] In one embodiment of the present invention, the other effective ingredients are selected from one or more of zinc chloride, sodium tripolyphosphate, xylitol, allantoin, dipotassium glycyrrhizinate, bisabolol / ginger root extract and sodium hyaluronate;

[0021] And / or, the pigment is selected from one or more of CI 42090, CI 17200, CI 19140 and CI 16035.

[0022] In one embodiment of the present invention, the oral care solution is a mouthwash or a mouth spray.

[0023] The second object of the present invention is to provide a method for preparing the oral care solution having the effect of improving oral health, characterized in that it comprises the following steps:

[0024] (1) Heat the water to sterilize it and then cool it before use;

[0025] (2) adding moisturizer, creatine, sweetener, anti-caries agent, water-soluble preservative and other water-soluble functional ingredients to water and stirring until all are dissolved uniformly;

[0026] (3) Evenly mixing flavors and fragrances, oil-soluble preservatives, other oil-soluble functional ingredients and solubilizers, and then adding them to the aqueous solution;

[0027] (4) adding sodium guaiacyl sulfonate, cetylpyridinium chloride, emblica fruit extract, and pigment to the aqueous solution and stirring to completely dissolve them evenly;

[0028] (5) Add a pH adjuster and adjust the pH to 7.0-9.0.

[0029] The above technical solution of the present invention has the following advantages compared with the prior art:

[0030] The present invention provides an oral care liquid with the effect of improving oral health and a preparation method thereof. The oral care liquid of the present invention is added with sodium guaiacylsulfonate, creatine, emblica fruit extract and other effective ingredients, and has the effects of anti-inflammatory, promoting ulcer healing, promoting granulation tissue regeneration; alleviating and reducing the stimulation of foreign objects to the oral mucosa, locking water and moisturizing, protecting the oral mucosa; helping to reduce harmful oral bacteria such as Fusobacterium nucleatum, Porphyromonas gingivalis, and Clostridium morellii, thereby improving the health of the oral mucosa, improving oral ulcers, alleviating gingival inflammation, improving halitosis, improving dry mouth, preventing dental caries and other multiple effects. The oral care liquid of the present invention improves the stability of sodium guaiacylsulfonate in the product by adding cetylpyridinium chloride and adjusting the product pH to be weakly alkaline, thereby ensuring the efficacy of the product within the shelf life of the product. DETAILED DESCRIPTION

[0031] The present invention is further described below in conjunction with specific embodiments so that those skilled in the art can better understand the present invention and implement it, but the embodiments are not intended to limit the present invention.

[0032] Unless otherwise specified, the experimental methods used in the following examples are all conventional methods, and the materials, reagents, etc. used are all available from commercial sources unless otherwise specified.

[0033] Example 1: Mouthwash formulation

[0034] This embodiment provides a mouthwash formula having the effect of improving oral health, which comprises the following components in terms of mass percentage:

[0035] Sodium guaiacyl sulfonate: 0.08%, Creatine: 1%, Emblica officinalis fruit extract: 1%, Cetylpyridinium chloride: 0.1%, Sodium pyrophosphate: 0.5%, Sorbitol: 5%, Propylene glycol: 5%, Sucralose: 0.005%, Fragrance: 0.2%, Sodium fluoride: 0.05%, Tween-20: 1%, Phenoxyethanol: 0.3%, Allantoin: 0.1%, CI 42090: 0.0001%, Water: Balance.

[0036] The production process of the mouthwash formula with the effect of improving oral health in this embodiment is as follows:

[0037] (1) Sterilize water by heating, and after cooling, add sorbitol, propylene glycol, phenoxyethanol, creatine, sucralose, sodium fluoride and allantoin according to the above-mentioned components, and stir to make them all dissolve evenly;

[0038] (2) mixing the essence and Tween-20 evenly, and then adding the mixture to the aqueous solution obtained in step (1);

[0039] (3) adding sodium guaiacyl sulfonate, cetylpyridinium chloride, emblica fruit extract and CI 42090 to the aqueous solution obtained in step (2), and stirring to completely dissolve them uniformly;

[0040] (4) Finally, sodium pyrophosphate was added to the solution obtained in step (3) to adjust the pH value to 8.5. 。

[0041] Example 2: Mouth spray formulation

[0042] This embodiment provides a mouth spray formula with the effect of improving oral health, which includes the following components in terms of mass percentage:

[0043] Sodium guaiacyl sulfonate: 0.02%, Creatine: 0.5%, Emblica officinalis fruit extract: 0.5%, Cetylpyridinium chloride: 0.05%, Sodium bicarbonate: 0.3%, Glycerin: 20%, Sorbitol: 5%, Sodium saccharin: 0.001%, Flavor: 0.6%, Menthol: 0.1%, WS-3: 0.05%, WS-23: 0.05%, Xylitol: 5%, PEG-40 hydrogenated castor oil: 5%, Caprylyl glycol / 1,2-hexanediol: 0.5%, Bisabolol / Ginger root extract: 0.1%, Water: Balance.

[0044] The production process of the mouth spray formula with the effect of improving oral health in this embodiment is:

[0045] (1) sterilizing water by heating, and after cooling, adding glycerol, sorbitol, creatine, xylitol and saccharin sodium according to the above-mentioned component contents, and stirring to make them all dissolve evenly;

[0046] (2) mixing the essence, menthol, WS-3, WS-23, caprylyl glycol / 1,2-hexanediol, bisabolol / ginger root extract and PEG-40 hydrogenated castor oil evenly, and then adding the mixture to the aqueous solution obtained in step (1);

[0047] (3) adding sodium guaiacyl sulfonate, cetylpyridinium chloride, and emblica fruit extract to the aqueous solution obtained in step (2), and stirring to completely dissolve them evenly;

[0048] (4) Finally, sodium bicarbonate was added to the solution obtained in step (3) to adjust the pH value to 8.5. 。

[0049] Test Example 1

[0050] (1) The effect of the mouthwash obtained in Example 1 on the area of ​​oral ulcers in rats was tested. Before the sample was administered, there was no statistically significant difference in the ulcer area between the model control group and the test sample group (P>0.05). After the sample was administered, the ulcer area of ​​the test sample group on the 5th day was reduced compared with the model control group, and the difference was statistically significant (P<0.05). See Table 1:

[0051] Table 1 Oral ulcer area of ​​rats ( n=10)

[0052]

[0053] Note: * indicates that compared with the model control group, P < 0.05

[0054] (2) Effect of the test sample on the healing of oral ulcers in rats. After sample administration, the decrease in ulcer area on the 5th day in the test sample group was statistically significant compared with the model control group (P<0.05). During the test period, the final healing rates of the model control group and the test sample group were both 0%. Compared with the model control group, the final ulcer area decrease rate in the test sample group increased, and the difference was statistically significant (P<0.05). See Table 2:

[0055] Table 2 Decrease in area and healing of oral ulcers in rats ( n=10)

[0056]

[0057] Note: * indicates that compared with the model control group, P < 0.05

[0058] Test Example 2

[0059] The mouthwash prepared in Example 1 was used for clinical testing, including oral odor testing and gingival inflammation testing. The test period was 28 days and the number of subjects was 18. The results are as follows:

[0060] In terms of reducing bad breath, 1 person had no bad breath after using it, 2 people did not feel any effect, 7 people had significantly reduced bad breath, and 8 people had a little reduced bad breath. It can be seen that the number of people who reported that their bad breath was reduced reached 88.9%.

[0061] In terms of reducing gum inflammation, 2 people had no oral inflammation after using it, 2 people did not feel any effect, 6 people had significantly reduced gum inflammation, and 8 people had slightly reduced gum inflammation after using it. It can be seen that the number of people who reported that oral inflammation such as gum bleeding was relieved reached 77.8%.

[0062] Obviously, the above embodiments are merely examples for clear explanation and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived from these are still within the protection scope of the invention.

Claims

1. An oral care solution having the effect of improving oral health, characterized in that: Calculated by mass percentage, it includes the following components: Sodium guaiacyl sulfonate: 0.01%-0.1%, creatine: 0.1%-1.4%, emblica fruit extract: 0.1-1%, cetylpyridinium chloride: 0.05%-0.1%, pH adjuster: 0.05%-1%, moisturizer: 5%-30%, sweetener: 0%-0.05%, flavor and fragrance: 0.1%-1%, anti-caries agent: 0.05%-5%, solubilizer: 0.5%-6%, preservative: 0.1%-1%, other functional ingredients: 0%-5%, pigment: 0%-0.01%, and the balance is water; the pH value of the oral care solution is 7.0-9.

0.

2. The oral care solution according to claim 1, characterized in that The pH adjuster is selected from one or more of sodium citrate, sodium tripolyphosphate, sodium bicarbonate, sodium hydroxide, disodium hydrogen phosphate, sodium pyrophosphate, sodium phosphate and citric acid-sodium citrate buffer.

3. The oral care solution according to claim 1, characterized in that The moisturizing agent is selected from one or more of sorbitol, glycerol, propylene glycol, xylitol and polyethylene glycol.

4. The oral care solution according to claim 1, characterized in that: The sweetener is selected from one or more of saccharin sodium, sucralose and stevioside; And / or, the flavor and fragrance is selected from one or more of flavor, menthol, menthone glycerol ketal, WS-3 and WS-23.

5. The oral care solution according to claim 1, characterized in that: The anti-caries agent is selected from one or more of sodium fluoride, sodium monofluorophosphate and xylitol.

6. The oral care solution according to claim 1, characterized in that: The solubilizing agent is selected from one or more of poloxamer 407, PEG-40 hydrogenated castor oil, PEG-60 hydrogenated castor oil and Tween-20.

7. The oral care solution according to claim 1, characterized in that: The preservative is selected from one or more of potassium sorbate, methylparaben, propylparaben, phenoxyethanol, caprylyl glycol / 1,2-hexanediol and cymene.

8. The oral care solution according to claim 1, characterized in that: The other effective ingredients are selected from one or more of zinc chloride, sodium tripolyphosphate, xylitol, allantoin, dipotassium glycyrrhizinate, bisabolol / ginger root extract and sodium hyaluronate; And / or, the pigment is selected from one or more of CI 42090, CI 17200, CI 19140 and CI 16035.

9. The oral care solution according to claim 1, characterized in that: The oral care solution is a mouthwash or a mouth spray.

10. The method for preparing the oral care solution having the effect of improving oral health according to any one of claims 1 to 9, characterized in that: The following steps are involved: (1) Heat the water to sterilize it and then cool it before use; (2) adding moisturizer, creatine, sweetener, anti-caries agent, water-soluble preservative and other water-soluble functional ingredients to water and stirring until all are dissolved uniformly; (3) Evenly mixing flavors and fragrances, oil-soluble preservatives, other oil-soluble functional ingredients and solubilizers, and then adding them to the aqueous solution; (4) adding sodium guaiacyl sulfonate, cetylpyridinium chloride, emblica fruit extract, and pigment to the aqueous solution and stirring to completely dissolve them evenly; (5) Add a pH adjuster and adjust the pH to 7.0-9.0.

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