Semi-permeable membrane replacement mechanism and colloid osmotic pressure tester

Abstract

The invention discloses a semi-permeable membrane replacement mechanism which comprises a bottom plate, and a mounting platform, a reagent driving structure, a flow control mechanism, a replacement driving mechanism and a transmission mechanism which are mounted above the bottom plate, a semi-permeable membrane fixing device is detachably mounted on the mounting platform, and a semi-permeable membrane is mounted in the semi-permeable membrane fixing device; a conveying mechanism communicated with the interior of the semipermeable membrane fixing device is arranged below the mounting platform, the reagent driving structure is connected with the conveying mechanism through a flow control mechanism and used for inputting or discharging different reagents into or out of the interior of the semipermeable membrane fixing device, and the replacement driving mechanism is connected with the mounting platform through a transmission mechanism. The mounting platform is driven by the replacement driving mechanism and the transmission mechanism to drive the semipermeable membrane fixing device to turn over, so that the semipermeable membrane fixing device is convenient to replace, the internal semipermeable membrane is further replaced, the mounting process is simplified, automatic control is realized, and the working efficiency is improved. The invention also discloses a colloid osmotic pressure tester comprising the semipermeable membrane replacement mechanism.

Description

Technical Field

[0001] The present invention relates to the field of medical equipment, and in particular to a semipermeable membrane replacement mechanism. In addition, the present invention also relates to a colloid osmotic pressure measuring instrument comprising the semipermeable membrane replacement mechanism. Background Art

[0002] The colloid osmotic pressure meter is a widely used medical device used to detect the osmotic pressure of colloids. Among them, the semipermeable membrane is an important component to achieve the above function. The protein in the sample cannot pass through the semipermeable membrane. Therefore, in the process of measuring the colloid osmotic pressure value of the sample, due to the existence of the colloid osmotic pressure, the sample will absorb the ions and small molecules on the other side of the semipermeable membrane to offset the colloid osmotic pressure value. Therefore, the semipermeable membrane must be replaced when it reaches the end of its service life.

[0003] In the prior art, the method for replacing the semipermeable membrane is: first, soak the semipermeable membrane until it is completely wet, then manually unscrew the screw cap above the semipermeable membrane, take out the sealing ring and the old semipermeable membrane, clean the cavity below the semipermeable membrane, inject reference solution, then install the new semipermeable membrane, install the sealing ring, and then tighten the screw cap.

[0004] The above-mentioned semipermeable membrane replacement method makes the process of replacing the semipermeable membrane complicated, has a high failure rate caused by excessive human operations, and takes a long time to replace.

[0005] Therefore, how to provide a semipermeable membrane replacement mechanism that can quickly and efficiently replace the semipermeable membrane is a technical problem that those skilled in the art currently need to solve. Summary of the invention

[0006] The purpose of the present invention is to provide a semipermeable membrane replacement mechanism, which drives the installation platform to drive the semipermeable membrane fixing device to flip by replacing the driving mechanism and the transmission mechanism, so as to facilitate the replacement of the semipermeable membrane fixing device, and then replace the internal semipermeable membrane, simplify the installation process, realize automatic control, and improve work efficiency. Another purpose of the present invention is to provide a colloidal osmotic pressure measuring instrument including the above-mentioned semipermeable membrane replacement mechanism.

[0007] In order to solve the above technical problems, the present invention provides a semipermeable membrane replacement mechanism, including a base plate and a mounting platform installed above the base plate, a reagent driving structure, a flow control mechanism, a replacement driving mechanism and a transmission mechanism, wherein a semipermeable membrane fixing device is detachably mounted on the mounting platform, a semipermeable membrane is installed inside the semipermeable membrane fixing device, a conveying mechanism connected to the interior of the semipermeable membrane fixing device is arranged below the mounting platform, the reagent driving structure is connected to the conveying mechanism through the flow control mechanism, and is used to input or discharge different reagents into or out of the interior of the semipermeable membrane fixing device, the replacement driving mechanism is connected to the mounting platform through the transmission mechanism, and is used to drive the mounting platform to flip forward so that the upper end of the semipermeable membrane fixing device tilts forward, or is used to drive the mounting platform to flip backward so that the semipermeable membrane fixing device is restored to a vertical state.

[0008] The replacement drive mechanism is a vertically arranged linear motor, and the transmission mechanism includes a base, a transmission plate and a connecting rod. The mounting platform is located at the front end of the base plate, and the base is located at the rear end of the base plate. The mounting platform is hinged to the base plate, and the rear end of the transmission plate is hinged to the base. A slide groove is provided on the lower surface of the middle part of the transmission plate, and the upper end of the screw rod of the linear motor is connected to a transmission shaft, and the transmission shaft is installed in the slide groove. The upper end of the connecting rod is hinged to the front end of the transmission plate, and the lower end of the connecting rod is hinged to the rear end of the mounting platform.

[0009] Preferably, a sealing column extending downward is provided at the front end of the transmission plate, and the lower end of the sealing column is inserted into the upper end opening of the semipermeable membrane fixing device when the semipermeable membrane fixing device is in a vertical state.

[0010] Preferably, the reagent driving structure is a peristaltic pump.

[0011] Preferably, the flow control mechanism includes a pinch valve and a sample loading handle, the sample loading handle is provided with a sample loading needle, the pinch valve is a two-position three-way valve, the three interfaces of the pinch valve are respectively connected to the inside of the semipermeable membrane fixing device, the reagent package and the external environment, and the sample loading handle manually controls the working status of the peristaltic pump and the pinch valve.

[0012] Preferably, the peristaltic pump, the pinch valve and the sample adding handle are located on the same side of the linear motor, and the pinch valve and the sample adding handle are located in front of the peristaltic pump.

[0013] Preferably, a reagent pack is detachably mounted under the bottom plate, a puncture needle under the bottom plate is inserted into the reagent pack, and the flow control mechanism is connected to the reagent pack via the puncture needle.

[0014] Preferably, an active buckle is provided below the bottom plate, and the active buckle is engaged with the upper end of the reagent pack. The lower end of the screw rod of the linear motor can trigger the active buckle to unlock so as to pop out the reagent pack.

[0015] Preferably, a guide hook matching the upper slideway of the reagent package is provided below the bottom plate.

[0016] The present invention provides a colloid osmotic pressure measuring instrument, comprising the semipermeable membrane replacement mechanism as described in any one of the above.

[0017] The present invention provides a semipermeable membrane replacement mechanism, comprising a base plate and a mounting platform mounted above the base plate, a reagent driving structure, a flow control mechanism, a replacement driving mechanism and a transmission mechanism, wherein a semipermeable membrane fixing device is detachably mounted on the mounting platform, a semipermeable membrane is mounted inside the semipermeable membrane fixing device, a conveying mechanism connected to the interior of the semipermeable membrane fixing device is arranged below the mounting platform, the reagent driving structure is connected to the conveying mechanism via the flow control mechanism, and is used for inputting or discharging different reagents into or out of the interior of the semipermeable membrane fixing device, and the replacement driving mechanism is connected to the mounting platform via the transmission mechanism.

[0018] When the semipermeable membrane needs to be replaced, the drive mechanism and the transmission mechanism are replaced to drive the installation platform to flip forward, and drive the upper end of the semipermeable membrane fixing device to tilt forward and extend out of the installation position to facilitate the removal of the old semipermeable membrane fixing device, and then install a new semipermeable membrane fixing device. The drive mechanism and the transmission mechanism are replaced to drive the installation platform to flip backward, and drive the upper end of the semipermeable membrane fixing device to flip backward, the semipermeable membrane fixing device returns to a vertical state, and the corresponding work continues.

[0019] By replacing the driving mechanism and the transmission mechanism, the installation platform is driven to flip the semipermeable membrane fixing device, which is convenient for replacing the semipermeable membrane fixing device, and then replacing the internal semipermeable membrane, simplifying the installation process, realizing automatic control, and improving work efficiency.

[0020] The present invention also provides a colloid osmotic pressure measuring instrument including the above-mentioned semipermeable membrane replacement mechanism. Since the above-mentioned semipermeable membrane replacement mechanism has the above-mentioned technical effects, the above-mentioned colloid osmotic pressure measuring instrument should also have the same technical effects, which will not be described in detail here. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] FIG1 is a schematic structural diagram of a specific embodiment of a semipermeable membrane replacement mechanism provided by the present invention;

[0022] FIG2 is a cross-sectional schematic diagram of a specific embodiment of the semipermeable membrane replacement mechanism provided by the present invention;

[0023] FIG. 3 is a bottom view schematically showing a specific embodiment of the semipermeable membrane replacement mechanism provided by the present invention.

[0024] Among them, the bottom plate 1, the mounting platform 2, the semipermeable membrane fixing device 3, the linear motor 4, the base 5, the transmission plate 6, the connecting rod 7, the slide groove 8, the screw 9, the transmission shaft 10, the sealing column 11, the peristaltic pump 12, the clamping valve 13, the sample adding handle 14, the movable buckle 15, the puncture needle 16, and the guide hook 17. DETAILED DESCRIPTION

[0025] The core of the present invention is to provide a semipermeable membrane replacement mechanism, which drives the installation platform to flip the semipermeable membrane fixing device by replacing the driving mechanism and the transmission mechanism, so as to facilitate the replacement of the semipermeable membrane fixing device, and then replace the internal semipermeable membrane, simplify the installation process, realize automatic control, and improve work efficiency. Another core of the present invention is to provide a colloid osmotic pressure measuring instrument including the above-mentioned semipermeable membrane replacement mechanism.

[0026] In order to enable those skilled in the art to better understand the solution of the present invention, the present invention is further described in detail below in conjunction with the accompanying drawings and specific implementation methods.

[0027] Please refer to Figures 1 to 3, Figure 1 is a structural schematic diagram of a specific embodiment of the semipermeable membrane replacement mechanism provided by the present invention; Figure 2 is a cross-sectional schematic diagram of a specific embodiment of the semipermeable membrane replacement mechanism provided by the present invention; Figure 3 is a bottom-up schematic diagram of a specific embodiment of the semipermeable membrane replacement mechanism provided by the present invention.

[0028] The specific embodiment of the present invention provides a semipermeable membrane replacement mechanism, including a horizontally arranged bottom plate 1 and a mounting platform 2 installed above the bottom plate 1, a reagent driving structure, a flow control mechanism, a replacement driving mechanism and a transmission mechanism, wherein a semipermeable membrane fixing device 3 is detachably mounted on the mounting platform 2, a semipermeable membrane is installed inside the semipermeable membrane fixing device 3, and it is a key component for osmotic pressure testing, and a conveying mechanism connected to the inside of the semipermeable membrane fixing device 3 is arranged below the mounting platform 2, which is used to convey reagents to the inside of the semipermeable membrane fixing device 3, or to discharge reagents inside the semipermeable membrane fixing device 3. Further, the reagent driving structure is connected to the conveying mechanism through the flow control mechanism, which is used to input or discharge different reagents into or out of the semipermeable membrane fixing device 3, the reagent driving structure provides power for the flow of the reagent, and the flow control mechanism controls the flow direction of the reagent, that is, the specific flow mode.

[0029] The replacement drive mechanism is connected to the installation platform 2 through the transmission mechanism. When the semipermeable membrane needs to be replaced, the replacement drive mechanism and the transmission mechanism drive the installation platform 2 to flip forward, and drive the upper end of the semipermeable membrane fixing device 3 to tilt forward and extend out of the installation position to facilitate the removal of the old semipermeable membrane fixing device 3, and then install the new semipermeable membrane fixing device 3. The replacement drive mechanism and the transmission mechanism drive the installation platform 2 to flip backward, and drive the upper end of the semipermeable membrane fixing device 3 to flip backward, the semipermeable membrane fixing device 3 returns to a vertical state, and continues the corresponding work.

[0030] By replacing the driving mechanism and the transmission mechanism, the installation platform 2 drives the semipermeable membrane fixing device 3 to flip, which facilitates the replacement of the semipermeable membrane fixing device 3 and then replaces the internal semipermeable membrane, simplifies the installation process, realizes automatic control, and improves work efficiency.

[0031] Specifically, the drive mechanism is replaced with a vertically arranged linear motor 4, the transmission mechanism includes a base 5, a transmission plate 6 and a connecting rod 7, and the front end and the rear end are defined according to the position of the mounting platform 2. The mounting platform 2 is located at the front end of the base plate 1, and the base 5 is located at the rear end of the base plate 1. The front end of the mounting platform 2 is hinged to the base plate 1, and the rear end of the transmission plate 6 is hinged to the base 5. A connecting structure is provided on the lower surface of the middle part of the transmission plate 6, and a slide groove 8 is provided on the connecting structure. The upper end of the screw rod 9 of the linear motor 4 is connected to a transmission shaft 10, and the transmission shaft 10 is installed in the slide groove 8. The upper end of the connecting rod 7 is hinged to the front end of the transmission plate 6, and the lower end of the connecting rod 7 is hinged to the rear end of the mounting platform 2. Among them, the extension direction of the slide groove 8 is parallel to the transmission plate 6, and the connecting rod 7 is a bending member, and the lower end of the connecting rod 7 is bent forward.

[0032] When the semipermeable membrane inside the semipermeable membrane fixture 3 reaches the service life, the semipermeable membrane needs to be replaced. At this time, the linear motor 4 drives the screw rod 9 to move upward, driving the transmission shaft 10 to move upward. While the transmission shaft 10 slides in the chute 8, it pushes the transmission plate 6 to move upward, and then drives the connecting rod 7 to move upward. When the connecting rod 7 transmits power, the installation platform 2 and the semipermeable membrane fixture 3 will realize the flipping motion, swing forward, and stop moving after flipping to the corresponding angle. At this time, take out the semipermeable membrane fixture 3 that has reached the service life, and replace it with a new semipermeable membrane fixture 3. At this time, the semipermeable membrane fixture 3 flips back to the original position and completes the replacement of the semipermeable membrane fixture 3. During the replacement process, when the sound of the ball plunger and the prompt of the touch switch below the semipermeable membrane fixture 4 are heard, it means that the replacement is completed.

[0033] Preferably, the front end of the transmission plate 6 is provided with a sealing column 11 extending downward. When the semipermeable membrane needs to be replaced, the replacement drive mechanism and the transmission mechanism drive the mounting platform 2 to flip forward, and drive the upper end of the semipermeable membrane fixture 3 to tilt forward, and at the same time, the front end of the mounting platform 2 drives the sealing column 11 to move upward, so that the sealing column 11 is separated from the upper end opening of the semipermeable membrane fixture 3. When the replacement is completed, the replacement drive mechanism and the transmission mechanism drive the mounting platform 2 to flip backward, and drive the upper end of the semipermeable membrane fixture 3 to flip backward, and the semipermeable membrane fixture 3 is restored to a vertical state. At the same time, the front end of the mounting platform 2 drives the sealing column 11 to move downward, so that the sealing column 11 is inserted into the upper end opening of the semipermeable membrane fixture 3, and the corresponding work continues.

[0034] In the semipermeable membrane replacement mechanism provided in the specific embodiment of the present invention, the reagent driving structure is a peristaltic pump 12. The peristaltic pump 12 is composed of a stepper motor and a peristaltic pump head, and is mainly used to inject the sample and the cleaning solution into the measuring chamber inside the semipermeable membrane fixing device 3. The peristaltic pump 12 has an adjustable speed and high precision, and has the advantages of high precision and low cross contamination.

[0035] Specifically, the flow control mechanism includes a clamping valve 13 and a sample adding handle 14. The sample adding handle 14 is provided with a sample adding needle. The clamping valve 13 is a two-position three-way valve. The three interfaces of the clamping valve 13 are respectively connected to the interior of the semipermeable membrane fixing device 3, the reagent pack and the external environment. The sample adding handle 14 manually controls the working state of the peristaltic pump 12 and the clamping valve 13. The clamping valve 13 cooperates with the Y-type connector to realize the function of a two-position three-way valve. One pipeline of the clamping valve 13 is connected to the interior of the semipermeable membrane fixing device 4, and the other two pipelines are respectively connected to the puncture needle 16 and the air. When connected to the puncture needle 16, the cleaning liquid can be sucked out from the inside of the reagent pack to clean the measuring chamber of the semipermeable membrane fixing device 3; when connected to the air, the sample inside the sample adding needle can be sucked into the measuring chamber of the semipermeable membrane fixing device 4 to realize the sample adding function.

[0036] Preferably, the peristaltic pump 12, the pinch valve 13 and the sample adding handle 14 are located on the same side of the linear motor 4, and the pinch valve 13 and the sample adding handle 14 are located in front of the peristaltic pump 12. The installation position and connection mode of each component can also be adjusted according to the situation, all within the protection scope of the present invention.

[0037] On the basis of the semipermeable membrane replacement mechanism provided in the above-mentioned specific embodiments, a reagent pack is detachably mounted below the bottom plate 1, and the puncture needle 16 below the bottom plate 1 is inserted into the reagent pack, and the flow control mechanism is connected to the reagent pack through the puncture needle 16. The puncture needle 16 is fixed below the bottom plate 1, and mainly realizes the puncture of the sealing rubber plug of the reagent pack. When the puncture is successful, it can be connected with the reagent bag inside the reagent pack, so as to realize the cleaning of the measurement chamber of the semipermeable membrane fixing device 4 and the recovery of the measurement waste liquid.

[0038] Preferably, a movable buckle 15 is provided below the base plate 1, and the movable buckle 15 is engaged with the upper end of the reagent pack. The lower end of the screw rod 9 of the linear motor 4 can trigger the unlocking of the movable buckle 15 to eject the reagent pack. The linear motor 4 is a through-type linear motor, and the upper end of the linear motor 4 is connected to the transmission shaft 10. When the linear motor 4 moves upward, the screw rod 9 drives the transmission shaft 10 to move upward. When the linear motor 4 moves downward, the lower part of the screw rod 9 contacts the spring rod of the movable buckle 15, and the corresponding buckle of the reagent pack is linked with the spring rod and lifted to eject the reagent pack. The buckle torsion spring fits the buckle through the buckle rotating shaft, so that the buckle is pressed downward to fix the reagent pack. A guide hook 17 matching the slideway at the upper end of the reagent pack is provided below the base plate 1, which plays a guiding role in the process of replacing the reagent pack and prevents the problem of position displacement when the reagent pack is replaced.

[0039] When replacing the reagent pack, align the QR code on the reagent pack with the barcode scanner on the colloid osmotic pressure meter, input the information of the new reagent pack into the colloid osmotic pressure meter, and then install the new reagent pack into the colloid osmotic pressure meter. Place the reagent pack at the corresponding position inside the colloid osmotic pressure meter, and push the reagent pack into the colloid osmotic pressure meter with force. At this time, the linear motor 4 moves upward, and the active buckle 15 applies downward pressure under the action of the buckle torsion spring to clamp the reagent pack, thereby completing the fixation of the reagent pack.

[0040] When it is necessary to add a sample, the sample adding handle 14 is lifted, and the sample is sucked under the power provided by the peristaltic pump 12, and the sample is present in the sample adding needle and the pipeline. After the sample adding handle 14 is put down, the clamping valve 13 is connected to the air, and the sample in the sample adding needle and the pipeline can be injected into the measuring chamber inside the semipermeable membrane fixing device 3; after the measurement is completed, the clamping valve 13 is switched to be connected to the reagent bag inside the reagent pack, and the measuring chamber inside the semipermeable membrane fixing device 3 can be cleaned. After the cleaning is completed, the waste liquid in the measuring chamber of the semipermeable membrane fixing device 3 is injected into the vacuum reagent belt inside the reagent pack to complete the recovery of the waste liquid.

[0041] Through the above method, automatic sample addition and cleaning are realized, the accurate sample addition amount is ensured, and the control accuracy is improved.

[0042] In addition to the above-mentioned semipermeable membrane replacement mechanism, a specific embodiment of the present invention further provides a colloid osmotic pressure measuring instrument including the above-mentioned semipermeable membrane replacement mechanism. For the structures of other parts of the colloid osmotic pressure measuring instrument, please refer to the prior art and will not be described in detail herein.

[0043] The above is a detailed introduction to the semipermeable membrane replacement mechanism and the colloid osmotic pressure measuring instrument provided by the present invention. Specific examples are used herein to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only used to help understand the method of the present invention and its core idea. It should be pointed out that for ordinary technicians in this technical field, without departing from the principle of the present invention, the present invention can also be improved and modified in a number of ways, and these improvements and modifications also fall within the scope of protection of the claims of the present invention.

Claims

1. A semipermeable membrane replacement mechanism, characterized in that: The invention comprises a bottom plate (1), a mounting platform (2) mounted above the bottom plate (1), a reagent driving structure, a flow control mechanism, a replacement driving mechanism and a transmission mechanism, wherein a semipermeable membrane fixing device (3) is detachably mounted on the mounting platform (2), a semipermeable membrane being mounted inside the semipermeable membrane fixing device (3), a conveying mechanism communicating with the inside of the semipermeable membrane fixing device (3) is arranged below the mounting platform (2), the reagent driving structure is connected to the conveying mechanism via the flow control mechanism, and is used to allow different reagents to be input into or discharged from the inside of the semipermeable membrane fixing device (3), and the replacement driving mechanism is connected to the mounting platform (2) via the transmission mechanism, and is used to drive the mounting platform (2) to flip forward so that the upper end of the semipermeable membrane fixing device (3) tilts forward, or to drive the mounting platform (2) to flip backward so that the semipermeable membrane fixing device (3) returns to a vertical state.

2. The semipermeable membrane replacement mechanism according to claim 1, characterized in that: The replacement drive mechanism is a vertically arranged linear motor (4), the transmission mechanism comprises a base (5), a transmission plate (6) and a connecting rod (7), the mounting platform (2) is located at the front end of the base plate (1), the base (5) is located at the rear end of the base plate (1), the mounting platform (2) is hinged to the base plate (1), the rear end of the transmission plate (6) is hinged to the base (5), a slide groove (8) is provided on the lower surface of the middle part of the transmission plate (6), the upper end of the lead screw (9) of the linear motor (4) is connected to a transmission shaft (10), the transmission shaft (10) is installed in the slide groove (8), the upper end of the connecting rod (7) is hinged to the front end of the transmission plate (6), and the lower end of the connecting rod (7) is hinged to the rear end of the mounting platform (2).

3. The semipermeable membrane replacement mechanism according to claim 2, characterized in that: A sealing column (11) extending downward is provided at the front end of the transmission plate (6); when the semipermeable membrane fixing device (3) is in a vertical state, the lower end of the sealing column (11) is inserted into the upper end opening of the semipermeable membrane fixing device (3).

4. The semipermeable membrane replacement mechanism according to claim 2, characterized in that: The reagent driving structure is a peristaltic pump (12).

5. The semipermeable membrane replacement mechanism according to claim 4, characterized in that: The flow control mechanism comprises a pinch valve (13) and a sample loading handle (14). The sample loading handle (14) is provided with a sample loading needle. The pinch valve (13) is a two-position three-way valve. The three interfaces of the pinch valve (13) are respectively connected to the interior of the semipermeable membrane fixing device (3), the reagent pack and the external environment. The sample loading handle (14) manually controls the working states of the peristaltic pump (12) and the pinch valve (13).

6. The semipermeable membrane replacement mechanism according to claim 5, characterized in that: The peristaltic pump (12), the pinch valve (13) and the sample adding handle (14) are located on the same side of the linear motor (4), and the pinch valve (13) and the sample adding handle (14) are located in front of the peristaltic pump (12).

7. The semipermeable membrane replacement mechanism according to any one of claims 2 to 6, characterized in that: A reagent pack is detachably mounted below the base plate (1), a puncture needle (16) below the base plate (1) is inserted into the reagent pack, and the flow control mechanism is connected to the reagent pack via the puncture needle (16).

8. The semipermeable membrane replacement mechanism according to claim 7, characterized in that: An active buckle (15) is provided below the base plate (1), and the active buckle (15) is engaged with the upper end of the reagent pack. The lower end of the lead screw (9) of the linear motor (4) can trigger the active buckle (15) to unlock, so as to eject the reagent pack.

9. The semipermeable membrane replacement mechanism according to claim 8, characterized in that: A guide hook (17) is provided below the bottom plate (1) and matches the slideway at the upper end of the reagent package.

10. A colloid osmotic pressure measuring instrument, characterized in that: It comprises the semipermeable membrane replacement mechanism as described in any one of claims 1 to 9.

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