The invention discloses a low-nitrogen gas-fired boiler synergy and white smoke eliminating integrated heat supply system and a regulating and control method. The system comprises a boiler room groupcontrol system and at least one heat supply subsystem, wherein each subsystem comprises a gas-fired boiler, a low-nitrogen combustion engine, a gas calorific value detector, an air blower, a horizontal flue, a vertical flue, a flue gas condensation heat energy recovery device, an air preheater, a flue gas-air uniform distribution mixer, an air duct, a flue gas sampling analyzer, a temperature andhumidity sensor, a flue gas white eliminating and defogging section, a flue gas heating uniform distribution section, a boiler subsystem control module and the like. According to the system and the method, not only can the corrosion of backflow flue gas condensation on the air blowers, the low-nitrogen combustion engines and the like after the low-nitrogen transformation of the gas-fired boilers be effectively solved, but also the emission of white smoke mist is effectively reduced, and on the premise of ensuring that a boiler room supplies heat as required, through the overall operation regulating and control method, the high-heat efficiency operation of the boilers is realized, the overall gas utilization efficiency of the boiler room is further improved, and the energy waste and pollutant emission are reduced.