Anti-dandruff composition for improving skin micro-ecology and application of anti-dandruff composition

Abstract

The invention discloses an anti-dandruff composition for improving skin micro-ecology and application of the anti-dandruff composition. The anti-dandruff composition is prepared from selenium disulfide, tetrahydromethyl pyrimidine carboxylic acid, a swertia bimaculata (SWERTIA BIMACUTATA) extract, fructo-oligosaccharide and hydrolyzed silk. The anti-dandruff composition provided by the invention can effectively inhibit excessive propagation of malassezia, can also promote propagation of scalp resident flora such as staphylococcus epidermidis, and is beneficial to reconstruction of scalp microbial ecological balance of dandruff crowds. Tests show that when the shampoo is applied to shampoo products, the problems of dandruff, itching in the head, oil in the head, peculiar smell and the like are well solved through tests of volunteers, and an excellent long-acting dandruff removing effect is shown.

Description

Technical Field

[0001] The invention relates to the technical field of daily chemical products, in particular to an anti-dandruff composition for improving skin microecology and application thereof. Background Art

[0002] There are a large number of microorganisms colonizing the surface of human skin. Different parts have different ecological niches, and the types and numbers of colonized microorganisms are also different. The scalp is a unique ecological niche. Its dense hair, large number of sweat glands, sebaceous glands and high relative humidity create suitable conditions for the colonization and growth of microorganisms. It has been reported that the cell density of microorganisms distributed on the scalp is as high as 10 3 ~10 5 CFU / mm 2 , mainly composed of Staphylococci, Propionibacterium and Malassezia.

[0003] Dandruff, also known as scalp pityriasis, is a common skin disease. Its characteristic manifestation is scalp desquamation accompanied by itching, usually without obvious inflammation. Excessive dandruff will affect personal image and cause psychological pressure. If patients pay too much attention to the problem of dandruff, they may develop inferiority complex and even affect social activities. Therefore, anti-dandruff and anti-itching are research hotspots in the field of cosmetic hair care.

[0004] Studies have shown that the production of dandruff is directly related to Malassezia. Malassezia globosa, Malassezia furfur and Malassezia pachydermatis can encode and secrete a variety of esterases, which enable them to survive and reproduce on human skin by breaking down the sebum produced by the sebaceous glands. Under the action of esterases, they hydrolyze triglycerides secreted by the sebaceous glands, consume saturated fatty acids, and release irritating unsaturated fatty acids (such as octadecenoic acid) and other inflammatory molecules, causing dandruff-related symptoms on the individual scalp. The former mainly induces skin desquamation, and the latter, as a ligand for the aromatic hydrocarbon receptor, participates in the irritating immune response during contact sensitization.

[0005] Malassezia is a fungus that can be inhibited from growing or even killed by using fungicides. However, people have found in practice that dandruff can be improved after using antifungal treatment against Malassezia, but it will relapse quickly after a period of time, indicating that antifungal treatment alone cannot achieve the desired effect.

[0006] As the research progressed, it was found that the mutual connections between the microbial flora in people with dandruff were significantly reduced, while the microbial flora in healthy people had more stable mutual connections. People also found that Propionibacterium bacteria can inhibit the reproduction of Staphylococcus by secreting related bacteriocins. Staphylococci inhibit the reproduction of Propionibacterium by metabolizing glycerol. This shows that there is a mutual restraint or even balance between the microbial flora. Therefore, the production of dandruff involves multiple microorganisms, rather than the result of the action of a single microorganism (Malassezia).

[0007] In summary, comprehensive treatment to restore the homeostasis between scalp microorganisms and between microorganisms and the environment is an effective means of removing dandruff. Summary of the invention

[0008] The technical problem to be solved by the present invention is to provide an anti-dandruff composition for improving skin microecology which is different from the prior art.

[0009] The specific technical solutions of the present invention are as follows:

[0010] A first object of the present invention is to provide the above anti-dandruff composition.

[0011] An anti-dandruff composition comprises the following components in parts by weight: 0.1-1 parts of selenium disulfide, 0.1-5 parts of ectoine, and 0.1-5 parts of Swertia BIMACULATA extract.

[0012] In one embodiment, the anti-dandruff composition comprises the following components in parts by weight: 0.5 parts of selenium disulfide, 2.5 parts of tetrahydromethylpyrimidine carboxylic acid, and 2.5 parts of Swertia BIMACULATA extract.

[0013] In some of the embodiments, the anti-dandruff composition further comprises the following components in parts by weight: 0.1-5 parts of oligofructose and 0.1-5 parts of hydrolyzed silk.

[0014] In one embodiment, the anti-dandruff composition further comprises the following components in parts by weight: 2.5 parts of oligofructose and 2.5 parts of hydrolyzed silk.

[0015] The selenium disulfide used in the anti-dandruff composition of the present invention is an inorganic compound with a chemical formula of SeS2, which is an orange-yellow to orange-red powder. Selenium disulfide can interfere with the synthesis of fungal cell walls and has an inhibitory effect on the growth of Malassezia. However, selenium disulfide is irritating and can cause adverse reactions such as contact dermatitis or hair loss. The amount of selenium disulfide added in conventional formulas is usually low to avoid irritation.

[0016] The ectoine, also known as ectoine, compounded in the anti-dandruff composition of the present invention is a very hydrophilic substance that can regulate osmotic pressure to form a stable protective film around skin cells and proteins, thereby calming and soothing irritated and damaged dandruff skin.

[0017] The Swertia BIMACULATA extract used in the anti-dandruff composition of the present invention is obtained by extracting the whole herb of Swertia BIMACULATA, an annual herb of the genus Swertia of the Gentianaceae family. The whole herb of Swertia BIMACULATA can cure acute icteric hepatitis, cholecystitis, urinary tract infection, gastroenteritis, malaria, cold and fever, poliomyelitis and the like. Modern research shows that the main active ingredient Swertia BIMACULATA glycoside contained in Swertia BIMACULATA has the effect of inhibiting the release of inflammatory mediators and the expression of cytokines, thereby reducing tissue damage and redness, can scavenge free radicals, reduce the damage of oxidative stress to cells, can regulate the body's immune response, and enhance the body's immunity.

[0018] The anti-dandruff composition of the present invention contains tetrahydromethylpyrimidine carboxylic acid and Swertia BIMACULATA extract, which can effectively moisturize and nourish, replenish the hydrolipid film on the surface of the skin, regulate osmotic pressure, scavenge free radicals, and inhibit inflammation, thereby maintaining and improving the skin barrier capacity, which is beneficial for the damaged dandruff skin to be well maintained and repaired, and maintains the metabolic balance of the stratum corneum. On the other hand, the experiment also found that the compounding of tetrahydromethylpyrimidine carboxylic acid and Swertia BIMACULATA extract can effectively reduce the irritation of the antifungal active substance selenium disulfide, so that the amount of selenium disulfide added is increased compared with the conventional amount, which is beneficial for the composition to exert a better anti-dandruff effect.

[0019] The oligofructose used in the anti-dandruff composition of the present invention is also called fructooligosaccharide or sucrose trisaccharide oligosaccharide. Oligofructose contains rich hydroxyl groups, which can effectively lock in moisture and increase the moisture content of the skin; it has a selective proliferation effect on beneficial bacteria such as bifidobacteria and lactobacilli, making the beneficial bacteria dominant, thereby inhibiting the growth of harmful bacteria.

[0020] The hydrolyzed silk used in the anti-dandruff composition of the present invention is rich in silk protein, peptides, amino acids, etc., which can effectively prevent hair and scalp from drying out; can effectively reduce the irritation of surfactants; and has ultraviolet absorption properties, which can partially protect hair from ultraviolet damage. Suitable hydrolyzed silk can come from XP (from Guangzhou Qiyuan Biotechnology Co., Ltd.).

[0021] The oligofructose and hydrolyzed silk contained in the anti-dandruff composition of the present invention can further replenish the hydrolipid film of the damaged dandruff skin, maintain the skin barrier, and promote and stabilize the normal metabolism of the stratum corneum. In addition, it can also promote the proliferation of scalp resident flora such as Staphylococcus epidermidis, which is beneficial to rebuild the scalp microbial ecological balance of dandruff patients.

[0022] The embodiment of the present invention also provides a method for preparing the Swertia BIMACULATA extract, comprising the following steps:

[0023] (1) Take the whole herb of deer sprout, dry it, and crush it; add 70% V / V ethanol aqueous solution with a weight of 3-5 times that of deer sprout, soak it for 12-24 hours; treat it with ultrasound, then wet-load it into a column, elute it with 70% V / V ethanol aqueous solution, and collect 2BV of the eluate;

[0024] (2) Rotate and evaporate the eluate until there is no alcohol, add an appropriate amount of pure water to the original volume; wet-pack the D101 resin column and perform dynamic adsorption at a flow rate of 1-2 BV / h; then elute with 3-5 BV of water, and then elute with 3-5 BV of 50% V / V ethanol aqueous solution, and collect the 50% V / V ethanol eluate;

[0025] (3) The 50% V / V ethanol eluate is rotary evaporated to obtain an extract, which is then diluted with a solvent to obtain an extract.

[0026] In some embodiments, the ultrasonic treatment in step (1) is: ultrasonication for 10-30 min at an ultrasonic power of 320 W.

[0027] In some embodiments, the solvent in step (3) is a methyl propylene glycol aqueous solution, and the amount of the methyl propylene glycol aqueous solution is 5-10 times the weight of the extract.

[0028] In some embodiments, the solvent in step (3) is a methylpropylene glycol aqueous solution, and the methylpropylene glycol aqueous solution is composed of methylpropylene glycol and water in a ratio of 2:1.

[0029] The present invention adopts a column chromatography method which is carried out entirely at room temperature, has simple processes and equipment, uses less solvent, and significantly improves the content of scutellaria baicalensis glycoside in the scutellaria baicalensis extract obtained by the preparation method, thereby improving its anti-inflammatory effect and free radical scavenging ability, thereby ensuring the efficacy of the anti-dandruff composition.

[0030] The anti-dandruff composition of the present invention can be used as an active additive in the preparation of cosmetics. The cosmetics can be shampoo, essence, conditioner and other hair care products.

[0031] The embodiment of the present invention also provides an anti-dandruff and antipruritic shampoo, comprising the following components in percentage by weight: 5% cocamidopropyl betaine, 5% lauroyl alanine, 0.25% guar hydroxypropyltrimethylammonium chloride, 15% sodium lauryl polyoxyethylene ether sulfate, 0.2% disodium EDTA, 1% cocamide MEA, 1.5% polyquaternium-7, 0.8% sodium chloride, 0.1% panthenol, 0.6% phenoxyethanol, 0.5% sodium benzoate, 0.32% citric acid, XIAMETER TM MEM-1785 Emulsion 1%, the above anti-dandruff composition 1-10%, the balance water.

[0032] The beneficial effects brought by the technical solution of the present invention are:

[0033] (1) The present invention provides an anti-dandruff composition for improving skin microecology that is different from the prior art. On the one hand, the anti-dandruff composition can effectively replenish the hydrolipid film of the damaged dandruff skin, remove free radicals, inhibit inflammation, and thus maintain the normal metabolism of the skin stratum corneum. On the other hand, while effectively inhibiting the excessive reproduction of Malassezia, it can also promote the proliferation of scalp resident flora such as Staphylococcus epidermidis, helping people with dandruff to rebuild the scalp microbial ecological balance.

[0034] (2) The present invention also provides an anti-dandruff and anti-itching shampoo, which uses the anti-dandruff composition for improving skin microecology. After being tested and tried by volunteers, the problems of dandruff, itchy scalp, oily scalp, odor, etc. were well solved, showing excellent long-term anti-dandruff effect. DETAILED DESCRIPTION

[0035] The following describes the embodiments of the present invention through specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention.

[0036] Before further describing the specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terms used in the examples of the present invention are for describing specific embodiments rather than for limiting the scope of protection of the present invention.

[0037] When the embodiment gives a numerical range, it should be understood that, unless otherwise specified in the present invention, the two endpoints of each numerical range and any numerical value between the two endpoints can be selected. Unless otherwise defined, all technical and scientific terms used herein have the same meanings as those of ordinary skill in the art to which the present invention belongs.

[0038] It is worth noting that the raw materials used in the present invention are all common commercially available products, so their sources are not specifically limited.

[0039] The XIAMETER TM MEM-1785 Emulsion is an emulsified silicone oil produced by DOW, an American chemical company. Its ingredients include: polydimethylsiloxane alcohol, water, and TEA dodecylbenzene sulfonate.

[0040] Example 1

[0041] A Swertia BIMACULATA extract is prepared by the following steps:

[0042] (1) Take the whole herb of deer sprout, dry it, and crush it; add 70% V / V ethanol aqueous solution with a weight of 3 times that of deer sprout, soak it for 24 hours; treat it with ultrasound at a power of 320W for 10 minutes, then wet-pack it into a column, elute it with 70% V / V ethanol aqueous solution, and collect 2BV of the eluate;

[0043] (2) The eluate was rotary evaporated until there was no alcohol, and an appropriate amount of pure water was added to the original volume; D101 resin was wet loaded on the column and dynamic adsorption was performed at a flow rate of 2 BV / h; then eluted with 3 BV of water, and then eluted with 50% V / V ethanol aqueous solution 5 BV, and the 50% V / V ethanol eluate was collected;

[0044] (3) The 50% V / V ethanol eluate is rotary evaporated to obtain an extract, and the extract is diluted with a methyl propylene glycol aqueous solution as a solvent, wherein the amount of the methyl propylene glycol aqueous solution is 5 times the weight of the extract, and the mass ratio of methyl propylene glycol to water in the methyl propylene glycol aqueous solution is 2:1; stirring to dissolve, centrifuging and taking the supernatant to obtain the extract.

[0045] Example 2

[0046] A Swertia BIMACULATA extract is prepared by the following steps:

[0047] (1) Take the whole herb of deer sprout, dry it, and crush it; add 70% V / V ethanol aqueous solution with a weight of 5 times that of deer sprout and soak it for 12 hours; treat it with ultrasound at a power of 320W for 30 minutes, then wet-pack it into a column, elute it with 70% V / V ethanol aqueous solution, and collect 2BV of the eluate;

[0048] (2) Rotate and evaporate the eluate until there is no alcohol, add an appropriate amount of pure water to the original volume; wet-pack the D101 resin into a column and perform dynamic adsorption at a flow rate of 1 BV / h; then elute with 5 BV of water, and then elute with 3 BV of 50% V / V ethanol aqueous solution, and collect the 50% V / V ethanol eluate;

[0049] (3) The 50% V / V ethanol eluate is rotary evaporated to obtain an extract, and the extract is diluted with a methyl propylene glycol aqueous solution as a solvent, wherein the amount of the methyl propylene glycol aqueous solution is 10 times the weight of the extract, and the mass ratio of methyl propylene glycol to water in the methyl propylene glycol aqueous solution is 2:1; stirring to dissolve, centrifuging and taking the supernatant to obtain the extract.

[0050] Example 3

[0051] A Swertia BIMACULATA extract is prepared by the following steps:

[0052] (1) Take the whole herb of deer sprout, dry it, and crush it; add 70% V / V ethanol aqueous solution with a weight of 4 times that of deer sprout, soak it for 18 hours; treat it with ultrasound at a power of 320W for 20 minutes, then wet-pack it into a column, elute it with 70% V / V ethanol aqueous solution, and collect 2BV of the eluate;

[0053] (2) Rotate and evaporate the eluate until there is no alcohol, add an appropriate amount of pure water to the original volume; wet-pack the D101 resin column and perform dynamic adsorption at a flow rate of 1.5 BV / h; then elute with 4 BV of water, and then elute with 4 BV of 50% V / V ethanol aqueous solution, and collect the 50% V / V ethanol eluate;

[0054] (3) The 50% V / V ethanol eluate is rotary evaporated to obtain an extract, and the extract is diluted with a methyl propylene glycol aqueous solution as a solvent, wherein the amount of the methyl propylene glycol aqueous solution is 8 times the weight of the extract, and the mass ratio of methyl propylene glycol to water in the methyl propylene glycol aqueous solution is 2:1; stirring to dissolve, centrifuging and taking the supernatant to obtain the extract.

[0055] Comparison group 1

[0056] A Swertia BIMACULATA extract is prepared by the following steps:

[0057] Take the whole herb of deer sprout, dry it and grind it; add a methylpropanediol aqueous solution with a weight of 8 times that of the deer sprout, wherein the mass ratio of methylpropanediol to water in the methylpropanediol aqueous solution is 2:1; keep warm and stir at 80°C for 1 hour; then use ultrasonic wave with a power of 320W for 20 minutes; centrifuge and take the supernatant to obtain the product.

[0058] Example 4

[0059] An anti-dandruff and antipruritic shampoo comprises the following components in percentage by weight: 5% of cocamidopropyl betaine, 5% of lauroyl alanine, 0.25% of guar hydroxypropyltrimethylammonium chloride, 15% of sodium lauryl polyoxyethylene ether sulfate, 0.2% of disodium EDTA, 1% of cocamide MEA, 1.5% of polyquaternium-7, 0.8% of sodium chloride, 0.1% of panthenol, 0.6% of phenoxyethanol, 0.5% of sodium benzoate, 0.32% of citric acid, and XIAMETER TM MEM-1785 Emulsion 1%, anti-dandruff composition 1%, the balance water.

[0060] The anti-dandruff composition comprises the following components in parts by weight: 0.1 parts of selenium disulfide, 5 parts of ectoine, and 0.1 parts of the Swertia BIMACULATA extract prepared in Example 1.

[0061] The preparation process of the anti-dandruff and anti-itching shampoo is as follows: after cleaning the stirring pot, add water, quickly sprinkle guar gum hydroxypropyl trimethyl ammonium chloride into it and stir it to homogenize, start heating to 60 degrees, add citric acid, continue stirring and heat to 80-85 degrees, and keep warm for 10 minutes; when it is 80-85 degrees, add cocamidopropyl betaine, lauroyl alanine, sodium lauryl polyoxyethylene ether sulfate, disodium EDTA, and cocamide MEA in sequence, keep warm and stir for 30 minutes until it is completely dissolved; when the temperature drops to 45 degrees, add polyquaternium-7, sodium chloride, panthenol, phenoxyethanol, sodium benzoate, XIAMETER TM MEM-1785 Emulsion and anti-dandruff composition are stirred evenly; pH ​​is adjusted to 5.5-6.5, and the material is filtered out.

[0062] Example 5

[0063] An anti-dandruff and antipruritic shampoo comprises the following components in percentage by weight: 5% of cocamidopropyl betaine, 5% of lauroyl alanine, 0.25% of guar hydroxypropyltrimethylammonium chloride, 15% of sodium lauryl polyoxyethylene ether sulfate, 0.2% of disodium EDTA, 1% of cocamide MEA, 1.5% of polyquaternium-7, 0.8% of sodium chloride, 0.1% of panthenol, 0.6% of phenoxyethanol, 0.5% of sodium benzoate, 0.32% of citric acid, and XIAMETER TM MEM-1785 Emulsion 1%, anti-dandruff composition 10%, and the balance water.

[0064] The anti-dandruff composition comprises the following components in parts by weight: 1 part of selenium disulfide, 0.1 part of tetrahydromethylpyrimidine carboxylic acid, and 5 parts of Swertia BIMACULATA extract prepared in Example 2.

[0065] The preparation process of the anti-dandruff and anti-itching shampoo is as follows: after cleaning the stirring pot, add water, quickly sprinkle guar gum hydroxypropyl trimethyl ammonium chloride into it and stir it to homogenize, start heating to 60 degrees, add citric acid, continue stirring and heat to 80-85 degrees, and keep warm for 10 minutes; when it is 80-85 degrees, add cocamidopropyl betaine, lauroyl alanine, sodium lauryl polyoxyethylene ether sulfate, disodium EDTA, and cocamide MEA in sequence, keep warm and stir for 30 minutes until it is completely dissolved; when the temperature drops to 45 degrees, add polyquaternium-7, sodium chloride, panthenol, phenoxyethanol, sodium benzoate, XIAMETER TM MEM-1785 Emulsion and anti-dandruff composition are stirred evenly; pH ​​is adjusted to 5.5-6.5, and the material is filtered out.

[0066] Example 6

[0067] An anti-dandruff and antipruritic shampoo comprises the following components in percentage by weight: 5% of cocamidopropyl betaine, 5% of lauroyl alanine, 0.25% of guar hydroxypropyltrimethylammonium chloride, 15% of sodium lauryl polyoxyethylene ether sulfate, 0.2% of disodium EDTA, 1% of cocamide MEA, 1.5% of polyquaternium-7, 0.8% of sodium chloride, 0.1% of panthenol, 0.6% of phenoxyethanol, 0.5% of sodium benzoate, 0.32% of citric acid, and XIAMETER TM MEM-1785 Emulsion 1%, anti-dandruff composition 5%, the balance water.

[0068] The anti-dandruff composition comprises the following components in parts by weight: 0.5 parts of selenium disulfide, 2.5 parts of tetrahydromethylpyrimidine carboxylic acid, and 2.5 parts of Swertia BIMACULATA extract prepared in Example 3.

[0069] The preparation process of the anti-dandruff and anti-itching shampoo is as follows: after cleaning the stirring pot, add water, quickly sprinkle guar gum hydroxypropyl trimethyl ammonium chloride into it and stir it to homogenize, start heating to 60 degrees, add citric acid, continue stirring and heat to 80-85 degrees, and keep warm for 10 minutes; when it is 80-85 degrees, add cocamidopropyl betaine, lauroyl alanine, sodium lauryl polyoxyethylene ether sulfate, disodium EDTA, and cocamide MEA in sequence, keep warm and stir for 30 minutes until it is completely dissolved; when the temperature drops to 45 degrees, add polyquaternium-7, sodium chloride, panthenol, phenoxyethanol, sodium benzoate, XIAMETER TM MEM-1785 Emulsion and anti-dandruff composition are stirred evenly; pH ​​is adjusted to 5.5-6.5, and the material is filtered out.

[0070] Example 7

[0071] An anti-dandruff and antipruritic shampoo comprises the following components in percentage by weight: 5% of cocamidopropyl betaine, 5% of lauroyl alanine, 0.25% of guar hydroxypropyltrimethylammonium chloride, 15% of sodium lauryl polyoxyethylene ether sulfate, 0.2% of disodium EDTA, 1% of cocamide MEA, 1.5% of polyquaternium-7, 0.8% of sodium chloride, 0.1% of panthenol, 0.6% of phenoxyethanol, 0.5% of sodium benzoate, 0.32% of citric acid, and XIAMETER TM MEM-1785 Emulsion 1%, anti-dandruff composition 5%, the balance water.

[0072] The anti-dandruff composition comprises the following components in parts by weight: 0.5 parts of selenium disulfide, 2.5 parts of tetrahydromethylpyrimidine carboxylic acid, 2.5 parts of Swertia BIMACULATA extract prepared in Example 3, 0.1 parts of oligofructose, and 5 parts of hydrolyzed silk.

[0073] The preparation process of the anti-dandruff and anti-itching shampoo is as follows: after cleaning the stirring pot, add water, quickly sprinkle guar gum hydroxypropyl trimethyl ammonium chloride into it and stir it to homogenize, start heating to 60 degrees, add citric acid, continue stirring and heat to 80-85 degrees, and keep warm for 10 minutes; when it is 80-85 degrees, add cocamidopropyl betaine, lauroyl alanine, sodium lauryl polyoxyethylene ether sulfate, disodium EDTA, and cocamide MEA in sequence, keep warm and stir for 30 minutes until it is completely dissolved; when the temperature drops to 45 degrees, add polyquaternium-7, sodium chloride, panthenol, phenoxyethanol, sodium benzoate XIAMETER TM MEM-1785 Emulsion and anti-dandruff composition are stirred evenly; pH ​​is adjusted to 5.5-6.5, and the material is filtered out.

[0074] Example 8

[0075] An anti-dandruff and antipruritic shampoo comprises the following components in percentage by weight: 5% of cocamidopropyl betaine, 5% of lauroyl alanine, 0.25% of guar hydroxypropyltrimethylammonium chloride, 15% of sodium lauryl polyoxyethylene ether sulfate, 0.2% of disodium EDTA, 1% of cocamide MEA, 1.5% of polyquaternium-7, 0.8% of sodium chloride, 0.1% of panthenol, 0.6% of phenoxyethanol, 0.5% of sodium benzoate, 0.32% of citric acid, and XIAMETER TM MEM-1785 Emulsion 1%, anti-dandruff composition 5%, the balance water.

[0076] The anti-dandruff composition comprises the following components in parts by weight: 0.5 parts of selenium disulfide, 2.5 parts of tetrahydromethylpyrimidine carboxylic acid, 2.5 parts of Swertia BIMACULATA extract prepared in Example 3, 5 parts of oligofructose, and 0.1 parts of hydrolyzed silk.

[0077] The preparation process of the anti-dandruff and anti-itching shampoo is as follows: after cleaning the stirring pot, add water, quickly sprinkle guar gum hydroxypropyl trimethyl ammonium chloride into it and stir it to homogenize, start heating to 60 degrees, add citric acid, continue stirring and heat to 80-85 degrees, and keep warm for 10 minutes; when it is 80-85 degrees, add cocamidopropyl betaine, lauroyl alanine, sodium lauryl polyoxyethylene ether sulfate, disodium EDTA, and cocamide MEA in sequence, keep warm and stir for 30 minutes until it is completely dissolved; when the temperature drops to 45 degrees, add polyquaternium-7, sodium chloride, panthenol, phenoxyethanol, sodium benzoate, XIAMETER TM MEM-1785 Emulsion and anti-dandruff composition are stirred evenly; pH ​​is adjusted to 5.5-6.5, and the material is filtered out.

[0078] Example 9

[0079] An anti-dandruff and antipruritic shampoo comprises the following components in percentage by weight: 5% of cocamidopropyl betaine, 5% of lauroyl alanine, 0.25% of guar hydroxypropyltrimethylammonium chloride, 15% of sodium lauryl polyoxyethylene ether sulfate, 0.2% of disodium EDTA, 1% of cocamide MEA, 1.5% of polyquaternium-7, 0.8% of sodium chloride, 0.1% of panthenol, 0.6% of phenoxyethanol, 0.5% of sodium benzoate, 0.32% of citric acid, and XIAMETER TM MEM-1785 Emulsion 1%, anti-dandruff composition 5%, the balance water.

[0080] The anti-dandruff composition comprises the following components in parts by weight: 0.5 parts of selenium disulfide, 2.5 parts of ectoine, 2.5 parts of Swertia BIMACULATA extract prepared in Example 3, 2.5 parts of oligofructose, and 2.5 parts of hydrolyzed silk.

[0081] The preparation process of the anti-dandruff and anti-itching shampoo is as follows: after cleaning the stirring pot, add water, quickly sprinkle guar gum hydroxypropyl trimethyl ammonium chloride into it and stir it to homogenize, start heating to 60 degrees, add citric acid, continue stirring and heat to 80-85 degrees, and keep warm for 10 minutes; when it is 80-85 degrees, add cocamidopropyl betaine, lauroyl alanine, sodium lauryl polyoxyethylene ether sulfate, disodium EDTA, and cocamide MEA in sequence, keep warm and stir for 30 minutes until it is completely dissolved; when the temperature drops to 45 degrees, add polyquaternium-7, sodium chloride, panthenol, phenoxyethanol, sodium benzoate, XIAMETERTM MEM-1785 Emulsion and anti-dandruff composition are stirred evenly; pH ​​is adjusted to 5.5-6.5, and the material is filtered out.

[0082] Comparative Example 1

[0083] An anti-dandruff and antipruritic shampoo comprises the following components in percentage by weight: 5% of cocamidopropyl betaine, 5% of lauroyl alanine, 0.25% of guar hydroxypropyltrimethylammonium chloride, 15% of sodium lauryl polyoxyethylene ether sulfate, 0.2% of disodium EDTA, 1% of cocamide MEA, 1.5% of polyquaternium-7, 0.8% of sodium chloride, 0.1% of panthenol, 0.6% of phenoxyethanol, 0.5% of sodium benzoate, 0.32% of citric acid, and XIAMETER TM MEM-1785 Emulsion 1%, anti-dandruff composition 5%, the balance water.

[0084] The anti-dandruff composition comprises the following components in parts by weight: 0.5 parts of selenium disulfide and 5 parts of tetrahydromethylpyrimidine carboxylic acid.

[0085] The preparation process of the anti-dandruff and anti-itching shampoo is as follows: after cleaning the stirring pot, add water, quickly sprinkle guar gum hydroxypropyl trimethyl ammonium chloride into it and stir it to homogenize, start heating to 60 degrees, add citric acid, continue stirring and heat to 80-85 degrees, and keep warm for 10 minutes; when it is 80-85 degrees, add cocamidopropyl betaine, lauroyl alanine, sodium lauryl polyoxyethylene ether sulfate, disodium EDTA, and cocamide MEA in sequence, keep warm and stir for 30 minutes until it is completely dissolved; when the temperature drops to 45 degrees, add polyquaternium-7, sodium chloride, panthenol, phenoxyethanol, sodium benzoate, XIAMETER TM MEM-1785 Emulsion and anti-dandruff composition are stirred evenly; pH ​​is adjusted to 5.5-6.5, and the material is filtered out.

[0086] Comparative Example 2

[0087] An anti-dandruff and antipruritic shampoo comprises the following components in percentage by weight: 5% of cocamidopropyl betaine, 5% of lauroyl alanine, 0.25% of guar hydroxypropyltrimethylammonium chloride, 15% of sodium lauryl polyoxyethylene ether sulfate, 0.2% of disodium EDTA, 1% of cocamide MEA, 1.5% of polyquaternium-7, 0.8% of sodium chloride, 0.1% of panthenol, 0.6% of phenoxyethanol, 0.5% of sodium benzoate, 0.32% of citric acid, and XIAMETER TM MEM-1785 Emulsion 1%, anti-dandruff composition 5%, the balance water.

[0088] The anti-dandruff composition comprises the following components in parts by weight: 0.5 parts of selenium disulfide and 5 parts of the Swertia BIMACULATA extract prepared in Example 3.

[0089] The preparation process of the anti-dandruff and anti-itching shampoo is as follows: after cleaning the stirring pot, add water, quickly sprinkle guar gum hydroxypropyl trimethyl ammonium chloride into it and stir it to homogenize, start heating to 60 degrees, add citric acid, continue stirring and heat to 80-85 degrees, and keep warm for 10 minutes; when it is 80-85 degrees, add cocamidopropyl betaine, lauroyl alanine, sodium lauryl polyoxyethylene ether sulfate, disodium EDTA, and cocamide MEA in sequence, keep warm and stir for 30 minutes until it is completely dissolved; when the temperature drops to 45 degrees, add polyquaternium-7, sodium chloride, panthenol, phenoxyethanol, sodium benzoate, XIAMETER TM MEM-1785 Emulsion and anti-dandruff composition are stirred evenly; pH ​​is adjusted to 5.5-6.5, and the material is filtered out.

[0090] Comparative Example 3

[0091] An anti-dandruff and antipruritic shampoo comprises the following components in percentage by weight: 5% of cocamidopropyl betaine, 5% of lauroyl alanine, 0.25% of guar hydroxypropyltrimethylammonium chloride, 15% of sodium lauryl polyoxyethylene ether sulfate, 0.2% of disodium EDTA, 1% of cocamide MEA, 1.5% of polyquaternium-7, 0.8% of sodium chloride, 0.1% of panthenol, 0.6% of phenoxyethanol, 0.5% of sodium benzoate, 0.32% of citric acid, and XIAMETER TM MEM-1785 Emulsion 1%, anti-dandruff composition 5%, the balance water.

[0092] The anti-dandruff composition comprises the following components in parts by weight: 0.5 parts of selenium disulfide, 2.5 parts of ectoine, 2.5 parts of Swertia BIMACULATA extract prepared in Example 3, and 5 parts of oligofructose.

[0093] The preparation process of the anti-dandruff and anti-itching shampoo is as follows: after cleaning the stirring pot, add water, quickly sprinkle guar gum hydroxypropyl trimethyl ammonium chloride into it and stir it to homogenize, start heating to 60 degrees, add citric acid, continue stirring and heat to 80-85 degrees, and keep warm for 10 minutes; when it is 80-85 degrees, add cocamidopropyl betaine, lauroyl alanine, sodium lauryl polyoxyethylene ether sulfate, disodium EDTA, and cocamide MEA in sequence, keep warm and stir for 30 minutes until it is completely dissolved; when the temperature drops to 45 degrees, add polyquaternium-7, sodium chloride, panthenol, phenoxyethanol, sodium benzoate, XIAMETER TMMEM-1785 Emulsion and anti-dandruff composition are stirred evenly; pH ​​is adjusted to 5.5-6.5, and the material is filtered out.

[0094] Comparative Example 4

[0095] An anti-dandruff and antipruritic shampoo comprises the following components in percentage by weight: 5% of cocamidopropyl betaine, 5% of lauroyl alanine, 0.25% of guar hydroxypropyltrimethylammonium chloride, 15% of sodium lauryl polyoxyethylene ether sulfate, 0.2% of disodium EDTA, 1% of cocamide MEA, 1.5% of polyquaternium-7, 0.8% of sodium chloride, 0.1% of panthenol, 0.6% of phenoxyethanol, 0.5% of sodium benzoate, 0.32% of citric acid, and XIAMETER TM MEM-1785 Emulsion 1%, anti-dandruff composition 5%, the balance water.

[0096] The anti-dandruff composition comprises the following components in parts by weight: 0.5 parts of selenium disulfide, 2.5 parts of tetrahydromethylpyrimidine carboxylic acid, 2.5 parts of Swertia BIMACULATA extract prepared in Example 3, and 5 parts of hydrolyzed silk.

[0097] The preparation process of the anti-dandruff and anti-itching shampoo is as follows: after cleaning the stirring pot, add water, quickly sprinkle guar gum hydroxypropyl trimethyl ammonium chloride into it and stir it to homogenize, start heating to 60 degrees, add citric acid, continue stirring and heat to 80-85 degrees, and keep warm for 10 minutes; when it is 80-85 degrees, add cocamidopropyl betaine, lauroyl alanine, sodium lauryl polyoxyethylene ether sulfate, disodium EDTA, and cocamide MEA in sequence, keep warm and stir for 30 minutes until it is completely dissolved; when the temperature drops to 45 degrees, add polyquaternium-7, sodium chloride, panthenol, phenoxyethanol, sodium benzoate, XIAMETER TM MEM-1785 Emulsion and anti-dandruff composition are stirred evenly; pH ​​is adjusted to 5.5-6.5, and the material is filtered out.

[0098] Comparative Example 5

[0099] An anti-dandruff and antipruritic shampoo comprises the following components in percentage by weight: 5% of cocamidopropyl betaine, 5% of lauroyl alanine, 0.25% of guar hydroxypropyltrimethylammonium chloride, 15% of sodium lauryl polyoxyethylene ether sulfate, 0.2% of disodium EDTA, 1% of cocamide MEA, 1.5% of polyquaternium-7, 0.8% of sodium chloride, 0.1% of panthenol, 0.6% of phenoxyethanol, 0.5% of sodium benzoate, 0.32% of citric acid, and XIAMETER TM MEM-1785 Emulsion 1%, anti-dandruff composition 5%, the balance water.

[0100] The anti-dandruff composition comprises the following components in parts by weight: 0.5 parts of selenium disulfide, 2.5 parts of ectoine, and 2.5 parts of Swertia BIMACULATA extract prepared in comparison group 1.

[0101] The preparation process of the anti-dandruff and anti-itching shampoo is as follows: after cleaning the stirring pot, add water, quickly sprinkle guar gum hydroxypropyl trimethyl ammonium chloride into it and stir it to homogenize, start heating to 60 degrees, add citric acid, continue stirring and heat to 80-85 degrees, and keep warm for 10 minutes; when it is 80-85 degrees, add cocamidopropyl betaine, lauroyl alanine, sodium lauryl polyoxyethylene ether sulfate, disodium EDTA, and cocamide MEA in sequence, keep warm and stir for 30 minutes until it is completely dissolved; when the temperature drops to 45 degrees, add polyquaternium-7, sodium chloride, panthenol, phenoxyethanol, sodium benzoate, XIAMETER TM MEM-1785 Emulsion and anti-dandruff composition are stirred evenly; pH ​​is adjusted to 5.5-6.5, and the material is filtered out.

[0102] Effect Example 1 Human Skin Patch Test

[0103] The human skin patch test is a test for measuring skin allergies (especially contact allergic reactions) and is currently the most reliable and simplest method for diagnosing contact dermatitis. The patch test is to prepare an appropriate concentration of immersion, solution, ointment or original substance as a reagent based on the properties of the test substance, apply it to the skin in an appropriate manner, and observe whether the body has a hypersensitivity reaction to it after a certain period of time.

[0104] This test is conducted on human skin patch test according to the method described in the "Technical Specifications for Safety of Cosmetics" (2015 edition). The selected area should not exceed 50mm 2 , a qualified spot test device with a depth of about 1mm. Put the test substance into the small chamber of the spot tester, and the amount is about 0.020mL-0.025mL. The test substance is a 2% dilution of the anti-dandruff and antipruritic shampoo prepared in Examples 4-9 and Comparative Examples 1-5; the control well is normal saline. The spot tester with the test substance added is applied to the curved side of the subject's forearm with a low-allergenic tape, and gently press it with the palm of the hand to evenly apply it to the skin for 24 hours. Observe the skin reaction according to the standards in Table 1 30 minutes (after the indentation disappears) and 48 hours after removing the test substance spot tester, and record the observation results in Table 2.

[0105] Table 1 Skin reaction grading standards for skin occlusive patch test

[0106]

[0107] Table 2 Summary of cosmetics human skin patch test results

[0108]

[0109] Table 2 Summary of cosmetics human skin patch test results

[0110]

[0111] As shown in Table 2, after removing the test object from the spot tester and observing for 48 hours, Examples 4-6 of the present invention each had 1-2 suspected reactions with only weak erythema; Examples 7-9 had 0 adverse skin reactions; Comparative Examples 1-2 had 4-5 suspected reactions with weak erythema, 2-3 weak positive reactions, and 1-2 strong positive reactions; Comparative Examples 3-4 had 1 suspected reaction with only weak erythema, and the negative control had 0 adverse skin reactions. Comparison of the results of Example 6 and Comparative Examples 1-2 shows that the embodiment of the present invention uses a compounding method of Swertia BIMACULATA extract and tetrahydromethylpyrimidine carboxylic acid to effectively reduce the irritation of anti-dandruff shampoo containing selenium disulfide. Comparison of the results of Example 6 and Comparative Example 5 shows that the Swertia BIMACULATA extract prepared in the embodiment of the present invention has a better effect.

[0112] Effect Example 2: Skin Microecology Regulation Test

[0113] This test evaluated the anti-dandruff and antipruritic shampoos prepared in Examples 4-9 and Comparative Examples 1-4 by the punching method described in the standard "GB / T 39101-2020 Polypeptide Antibacterial Test Inhibition Zone Method". First, the skin resident bacteria (including: Propionibacterium acnes, Staphylococcus capitis, Staphylococcus epidermidis, Malassezia furfur) were cultured separately, and the strains were washed off the slant culture medium with sterile saline to prepare a concentration of 1×10 8 cfu / mL~5×10 8 cfu / mL bacterial suspension. Test plate preparation: sterilize the prepared blood agar at high temperature and high pressure, wait for it to cool to 45℃-50℃, add 5-10mL of defibrinated sheep blood or rabbit blood to every 100mL of basic culture medium, mix well, add the prepared indicator bacteria suspension to the blood agar at an addition amount of 1% (i.e., add 1mL of bacterial suspension to 100mL of blood agar), mix well again, measure 20mL with a pipette and pour it into the sterilized plate, gently shake the plate to make it evenly flat, and wait for it to solidify for use. Use a sterilized puncher to punch holes on the test plate, punch 5 holes on each plate, inject a certain amount (about 100μL) of the sample to be tested (actual concentration) into 4 holes, and inject a certain amount of sterile saline into the remaining hole as a negative control. Place it in an anaerobic culture at 37℃ and culture it upright for 24h to observe the results. Use a vernier caliper to measure the diameter of the antibacterial ring and record the results as shown in Table 3. The test was repeated 3 times.

[0114] Table 3 Summary of antibacterial test results

[0115] Test Group Propionibacterium acnes Staphylococcus capitis Staphylococcus epidermidis Malassezia furfur Example 4 Antibacterial diameter mm 8.3 6.9 6.9 10.2 Example 5 Antibacterial diameter mm 8.5 6.8 6.8 10.3 Example 6 Antibacterial diameter mm 8.4 6.8 6.7 10.1 Example 7 Antibacterial diameter mm 8.6 6.1 6.2 10.4 Example 8 Antibacterial diameter mm 8.7 6.3 6.1 10.5 Example 9 Antibacterial diameter mm 8.9 6.2 6.3 10.5 Comparative Example 1 Antibacterial diameter mm 7.8 6.8 6.7 9.8 Comparative Example 2 Antibacterial diameter mm 7.9 6.9 6.9 9.7 Comparative Example 3 Antibacterial diameter mm 8.3 6.6 6.5 10.2 Comparative Example 4 Antibacterial diameter mm 8.4 6.9 6.8 10.1

[0116] As shown in Table 3, the antidandruff shampoo prepared in Examples 4-9 of the present invention has an antibacterial diameter greater than 7 mm for Propionibacterium acnes and Malassezia furfur, showing a good inhibitory effect, and an antibacterial diameter less than 7 mm for Staphylococcus capitis and Staphylococcus epidermidis, showing no inhibitory effect. It can be seen that the antidandruff shampoo prepared in the examples of the present invention has a good effect on rebuilding the balance of microbial flora in people with dandruff.

[0117] Effect Example 3 Volunteer Subjective Evaluation Test

[0118] 150 adult volunteers, regardless of gender or age, who were troubled by scalp itching, excessive sebum secretion, or abnormally dry scalp and dandruff were recruited and randomly divided into 5 groups, 30 in each group, to test the anti-dandruff and antipruritic shampoos prepared in Examples 6 and 9 and Comparative Examples 3-5, respectively.

[0119] Directions: Soak your hair with warm water at 35-40℃. Take an appropriate amount of anti-dandruff and anti-itch shampoo, rub it with your palms to make bubbles, then apply it to your hair and rub it gently for 3-5 minutes to make sure that the shampoo product covers the scalp evenly. Then rinse your hair and scalp with running warm water and dry your hair with a towel. Wash once every night for 4 consecutive weeks. A follow-up visit was conducted in the 4th week, and it was found that most volunteers' problems such as dandruff, itchy scalp, oily scalp, and odor were well resolved, and no irritation was reported. The self-evaluation results of the volunteers were collected, as shown in Table 4.

[0120] Table 4 Summary of the self-evaluation results of volunteers on anti-dandruff and antipruritic shampoo

[0121] Group Number of people with significant effect Effective number of people Improve the number of people Invalid number of people Example 6 0 4 14 12 Example 9 8 15 7 0 Comparative Example 3 0 5 20 5 Comparative Example 4 0 7 17 6 Comparative Example 5 0 2 9 19

[0122] As shown in Table 4, the anti-dandruff shampoo prepared in Example 6 of the present invention achieved an effective rate of 60%, which was significantly higher than that of Comparative Example 5 in which the Swertia BIMACULATA extract prepared by conventional process was added. The anti-dandruff shampoo prepared in Example 9 of the present invention achieved an effective rate of 100%, and the apparent effective rate reached 26.6%. The anti-dandruff shampoo prepared in Comparative Examples 3-4 also achieved an effective rate of more than 80%, but the apparent effective rate was poor, indicating that the compounding of oligofructose and hydrolyzed silk improved the effect of the anti-dandruff and antipruritic shampoo.

[0123] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Any simple modification or equivalent substitution made by any technician familiar with the technical field within the technical scope disclosed by the present invention does not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. An anti-dandruff composition, characterized in that: The invention comprises the following components in parts by weight: 0.1-1 parts of selenium disulfide, 0.1-5 parts of ectoine carboxylic acid and 0.1-5 parts of Swertia BIMACULATA extract.

2. The anti-dandruff composition according to claim 1, characterized in that The invention comprises the following components in parts by weight: 0.5 parts of selenium disulfide, 2.5 parts of tetrahydromethylpyrimidine carboxylic acid, and 2.5 parts of Swertia BIMACULATA extract.

3. The anti-dandruff composition according to claim 1, characterized in that The invention also comprises the following components in parts by weight: 0.1-5 parts of oligofructose and 0.1-5 parts of hydrolyzed silk.

4. The anti-dandruff composition according to claim 3, characterized in that The invention also includes the following components in parts by weight: 2.5 parts of oligofructose and 2.5 parts of hydrolyzed silk.

5. The anti-dandruff composition according to claim 1 or 2, characterized in that: The preparation method of the Swertia BIMACULATA extract comprises the following steps: (1) Take the whole herb of deer sprout, dry it, and crush it; add 70% V / V ethanol aqueous solution with a weight of 3-5 times that of deer sprout, soak it for 12-24 hours; treat it with ultrasound, then wet-load it into a column, elute it with 70% V / V ethanol aqueous solution, and collect 2BV of the eluate; (2) Rotate and evaporate the eluate until there is no alcohol, add an appropriate amount of pure water to the original volume; wet-pack the D101 resin column and perform dynamic adsorption at a flow rate of 1-2 BV / h; then elute with 3-5 BV of water, and then elute with 3-5 BV of 50% V / V ethanol aqueous solution, and collect the 50% V / V ethanol eluate; (3) The 50% V / V ethanol eluate is rotary evaporated to obtain an extract, which is then diluted with a solvent to obtain an extract.

6. The anti-dandruff composition according to claim 5, characterized in that The ultrasonic treatment in step (1) is as follows: ultrasonic treatment for 10-30 min at an ultrasonic power of 320 W.

7. The anti-dandruff composition according to claim 5, characterized in that The solvent in step (3) is a methyl propylene glycol aqueous solution, and the amount of the methyl propylene glycol aqueous solution is 5-10 times the weight of the extract.

8. The anti-dandruff composition according to claim 7, characterized in that The mass ratio of methylpropylene glycol to water in the methylpropylene glycol aqueous solution is 2:

1.

9. Use of the anti-dandruff composition according to any one of claims 1 to 8 as an active additive in the preparation of cosmetics.

10. An anti-dandruff and antipruritic shampoo, characterized in that: Contains the following components by mass percentage: 5% cocamidopropyl betaine, 5% lauroyl alanine, 0.25% guar hydroxypropyltrimonium chloride, 15% sodium lauryl polyoxyethylene ether sulfate, 0.2% disodium EDTA, 1% cocamide MEA, 1.5% polyquaternium-7, 0.8% sodium chloride, 0.1% panthenol, 0.6% phenoxyethanol, 0.5% sodium benzoate, 0.32% citric acid, XIAMETER TM MEM-1785 Emulsion 1%, the anti-dandruff composition according to any one of claims 1 to 8 1-10%, and the balance water.

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