Acne removing composition for fading acne marks and preparation method thereof

Abstract

The invention relates to the technical field of skin care products, and particularly discloses an acne removing composition for fading acne marks and a preparation method thereof. The acne-removing composition for fading acne marks is prepared by compounding an olive leaf extract, a clausena lansium bark extract, an artemisia annua extract, a podocarpus macrophyllus extract, a hydrolyzed opuntia ficus-indica flower extract and a silybum marianum extract. The preparation method of the acne-removing composition for fading acne marks comprises the following steps: 1) uniformly mixing an olive leaf extract, a clausena lansium bark extract, an artemisia annua extract, a podocarpus macrophyllus extract, a hydrolyzed opuntia ficus-indica flower extract, a silybum marianum extract and a solvent to obtain a plant extract; the invention relates to a preparation method of an acne-removing composition capable of fading acne marks, which comprises the following steps: 1) preparing a plant extract, 2) adding compound bacteria into the plant extract for fermentation to obtain a fermentation broth, and 3) sterilizing the fermentation broth, concentrating and drying to obtain the acne-removing composition capable of fading acne marks, the compound bacteria being a compound of cryptococcus laurentii, Wickerhamomyces anomalus and Candida boidinii, and the acne-removing composition capable of fading acne marks has the advantages of rapidly removing acnes and rapidly fading acne marks.

Description

Technical Field

[0001] The invention relates to the field of skin care products, and in particular to an acne-removing composition for fading acne marks and a preparation method thereof. Background Art

[0002] Acne may be caused by excessive secretion of oil by the sebaceous glands. Excessive oil secretion leads to abnormal keratinization of the sebaceous gland ducts, which means too much waste keratin, narrowing and blocking the hair follicle opening, allowing a large number of microorganisms to breed and accumulate. As the oil and keratin cells abnormally differentiate and accumulate, inflammation occurs, and acne grows on the skin. If not properly treated, these acne will continue to be infected and inflamed by bacteria, and eventually develop into papules, nodules, cysts, and leave scars and acne marks.

[0003] When acne breaks out, it causes blood vessels to dilate. After the acne disappears, the blood vessels do not shrink immediately, resulting in the formation of some red acne marks. The inflammatory reaction in the hair follicles of the skin causes damage to the skin tissue. The pigmentation after the inflammation will leave color in the areas where the acne has occurred, thus deepening the red acne marks.

[0004] The formation of acne scars will seriously affect the appearance. However, most acne removal products on the market are mainly antibacterial and anti-inflammatory, and their effectiveness in fading acne scars is relatively general. It is difficult to meet consumers' needs for quickly fading acne scars. Therefore, there is still room for improvement. Summary of the invention

[0005] In order to achieve rapid acne removal and rapid fading of acne marks, the present application provides an acne removal composition for fading acne marks and a preparation method thereof.

[0006] In the first aspect, the present application provides an acne-removing composition for fading acne marks, which adopts the following technical solution: The invention discloses an acne-removing composition for fading acne marks, comprising a compound of olive leaf extract, phellodendron chinense bark extract, artemisia annua extract, podocarpus macrophylla extract, hydrolyzed opuntia cactus flower extract and milk thistle extract.

[0007] By adopting the above technical scheme, through the compounding of olive leaf extract, yellow pine bark extract, artemisia annua extract, podocarpus extract, hydrolyzed prickly pear cactus flower extract, and milk thistle extract, the active ingredients of each extract cooperate with each other, which can reduce skin inflammatory response and fade acne marks while controlling acne. It can not only remove acne, but also eliminate acne marks. The acne removal and fading of acne marks are effective quickly, and the skin can be repaired quickly, reducing the troubles caused by acne to consumers, thereby meeting the needs of consumers well.

[0008] Preferably, the mass ratio of the olive leaf extract, the pomelo bark extract, the artemisia annua extract, the podocarpus extract, the hydrolyzed opuntia cactus flower extract, and the milk thistle extract is 0.9-1: 0.9-1: 0.9-1: 0.5-0.6: 0.2-0.3: 0.2-0.3.

[0009] By adopting the above technical scheme and specifically selecting the mass ratios of olive leaf extract, phellodendron chinense bark extract, artemisia annua extract, podocarpus macrophylla extract, hydrolyzed opuntia cactus flower extract and milk thistle extract, the effect of removing acne and fading acne marks is made more significant, the effect is seen faster, and the skin can be repaired faster.

[0010] Preferably, the olive leaf extract, phellodendron chinense bark extract, artemisia annua extract, podocarpus macrophylla extract, hydrolyzed opuntia cactus flower extract, and milk thistle extract are all water-soluble extracts.

[0011] By adopting the above technical solution and specifically selecting water-soluble extracts, the active ingredients of each extract can be more easily absorbed by the skin, and the effects of removing acne and eliminating acne marks are better and take effect faster.

[0012] In a second aspect, the present application provides a method for preparing an acne-removing composition for fading acne marks, using the following technical solution: A method for preparing the above-mentioned acne-removing composition for fading acne marks comprises the following steps: Step 1), olive leaf extract, pomelo bark extract, artemisia annua extract, podocarpus extract, hydrolyzed opuntia cactus flower extract, milk thistle extract, and solvent are mixed uniformly to obtain a plant extract; Step 2), adding composite bacteria to the plant extract for fermentation to obtain a fermentation liquid; Step 3), sterilizing the fermented liquid, concentrating and drying it to obtain an acne-removing composition for fading acne marks.

[0013] The composite bacteria is a combination of Cryptococcus laurentii, Wickham's yeast and Candida boidinii.

[0014] By adopting the above technical scheme, by using a composite bacteria composed of Cryptococcus laurensis, Wickham's yeast and Candida boidinii to ferment the extract composed of olive leaf extract, Phellodendron chinense bark extract, Artemisia annua extract, Podocarpus extract, hydrolyzed Opuntia cactus flower extract and Milk thistle extract, the macromolecular active ingredients in the olive leaf extract, Phellodendron chinense bark extract, Artemisia annua extract, Podocarpus extract, hydrolyzed Opuntia cactus flower extract and Milk thistle extract can be converted into small molecule active ingredients, which are easier to be absorbed by the skin, and the active ingredients can better reach the deep skin. At the same time, the active ingredients of each extract can cooperate with the special fermentation product to exert a better synergistic effect, which can make the effect of removing acne and fading acne marks faster, can repair the skin faster, and better meet the needs of consumers.

[0015] Preferably, in the composite bacteria, the mass ratio of Cryptococcus laurentii, Wickhamella anomala and Candida boidinii is 0.001-0.002:0.001-0.002:0.001-0.002.

[0016] By adopting the above technical scheme and specifically selecting the mass ratio of Cryptococcus laurentii, Wickham's yeast and Candida boidinii, the fermentation product and the active ingredients can be better matched, the synergistic effect can be better exerted, and the effect of removing acne and fading acne marks can be further accelerated.

[0017] Preferably, the solvent is a mixture of butanediol and deionized water.

[0018] By adopting the above technical solution and specifically selecting the solvent as a compound of butanediol and deionized water, the dissolution rate of each extract in the solvent is made faster, so that the fermentation effect is better.

[0019] Preferably, the mass ratio of the butanediol to deionized water is 20-30:70-80.

[0020] By adopting the above technical solution and specifically selecting the mass ratio of butanediol and deionized water, the solubility of each extract in the solvent is higher, and the anti-acne composition after fermentation has better efficacy.

[0021] Preferably, in step 1), the mass ratio of olive leaf extract, pomelo bark extract, artemisia annua extract, podocarpus extract, hydrolyzed opuntia cactus flower extract, milk thistle extract, and solvent is 0.9-1: 0.9-1: 0.9-1: 0.5-0.6: 0.2-0.3: 0.2-0.3: 20-25.

[0022] By adopting the above technical scheme and specifically selecting the mass ratio of olive leaf extract, phellodendron chinense bark extract, artemisia annua extract, podocarpus extract, hydrolyzed opuntia cactus flower extract, milk thistle extract and solvent, the fermentation effect is better and the product quality is better.

[0023] Preferably, in step 2), the mass ratio of the plant extract to the composite bacteria is 23.6-29.2:0.003-0.006.

[0024] By adopting the above technical solution and specifically selecting the mass ratio of the plant extract and the compound bacteria, a better fermentation effect can be ensured while the cost can be effectively controlled, thus having a higher economic value.

[0025] Preferably, in step 2), during fermentation, the fermentation temperature is 34-36° C. and the fermentation time is 6-7 days.

[0026] By adopting the above technical scheme and specifically selecting the fermentation temperature and fermentation time, the activity of the composite bacteria is higher, the fermentation efficiency is higher, and the fermentation degree is just right, so that the active ingredients and the fermentation products cooperate better, and the acne-removing composition has better effects in removing acne and fading acne marks.

[0027] In summary, this application has the following beneficial effects: 1. Since the present application is compounded with olive leaf extract, yellow bark tree bark extract, artemisia annua extract, Podocarpus macrophylla extract, hydrolyzed prickly pear cactus flower extract, and milk thistle extract, the active ingredients of each extract cooperate with each other to reduce skin inflammatory reactions while controlling acne, and fade acne marks. It can both remove acne and eliminate acne marks, and the effects of removing acne and fading acne marks are fast, which can quickly repair the skin, reduce the troubles caused by acne to consumers, and well meet the needs of consumers.

[0028] 2. In the present application, it is preferred to ferment the extract prepared by mixing olive leaf extract, yellow bark extract, Artemisia annua extract, Podocarpus extract, hydrolyzed prickly pear cactus flower extract and milk thistle extract with a composite bacteria composed of Cryptococcus laurensis, Wickham's yeast and Candida boidinii. This can convert the macromolecular active ingredients in olive leaf extract, yellow bark extract, Artemisia annua extract, Podocarpus extract, hydrolyzed prickly pear cactus flower extract and milk thistle extract into small molecule active ingredients, which are easier to be absorbed by the skin, and the active ingredients can better reach the deep skin. At the same time, the active ingredients of each extract can cooperate with the special fermentation product to exert a better synergistic effect, which can make the effect of removing acne and fading acne marks faster, repair the skin faster, and better meet the needs of consumers. DETAILED DESCRIPTION

[0029] The present application is further described in detail below with reference to the embodiments.

[0030] Example 1 An acne-removing composition for fading acne marks, and a preparation method of the acne-removing composition for fading acne marks comprises the following steps: Step 1), 0.9 kg olive leaf extract, 0.9 kg yellow bark tree extract, 0.9 kg artemisia annua extract, 0.5 kg Podocarpus extract, 0.2 kg hydrolyzed prickly pear cactus flower extract, 0.2 kg milk thistle extract, 20 kg butanediol, 80 kg deionized water are put into a fermentation tank, the speed is 120 r / min, stirred for 15 min, mixed evenly, to obtain a plant extract.

[0031] Step 2), adding 0.001 kg of Cryptococcus laurentii, 0.001 kg of Wickham's yeast, and 0.001 kg of Candida boidinii to the plant extract, keeping the temperature at 34° C. and fermenting for 6 days to obtain a fermentation liquid.

[0032] Step 3), the fermentation liquid is filtered through a 0.22 μm filter membrane for sterilization, and after sterilization, it is concentrated to a paste by rotary evaporation, the rotary evaporation pressure is 0.01 MPa, and the rotary evaporation temperature is 60° C., and then the paste is sprayed with powder and dried to obtain an acne-removing composition for fading acne marks.

[0033] Olive leaf extract was purchased from Shaanxi Junhe Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0034] The Phellodendron chinense bark extract was purchased from Shanghai Songhao Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0035] Artemisia annua extract was purchased from Gansu Yishengxiang Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0036] Podocarpus macrophylla extract was purchased from Gansu Yishengxiang Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0037] The hydrolyzed Opuntia cactus flower extract was purchased from Guangzhou Bisheng Trading Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0038] Milk thistle extract was purchased from Shandong Aicai Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0039] Butanediol is commercially available, CAS number: 110-63-4.

[0040] Cryptococcus laurensis was purchased from Beijing Biobio Biotech Co., Ltd., platform number: Bio-76080.

[0041] Abnormal Wickham yeast was purchased from Beijing Bio-Bowei Biotechnology Co., Ltd., platform number: Bio-65131.

[0042] Candida boidinii was purchased from Beijing Biobio Biotech Co., Ltd., platform number: Bio-53361.

[0043] Example 2 An acne-removing composition for fading acne marks, and a preparation method of the acne-removing composition for fading acne marks comprises the following steps: Step 1), 0.95kg of olive leaf extract, 0.95kg of Phellodendron chinense bark extract, 0.95kg of Artemisia annua extract, 0.55kg of Podocarpus macrophylla extract, 0.25kg of hydrolyzed Opuntia ficus-indica flower extract, 0.25kg of Milk thistle extract, 25kg of butylene glycol, and 75kg of deionized water are put into a fermentation tank, the speed is 120r / min, and the mixture is stirred for 18min to obtain a plant extract.

[0044] Step 2), adding 0.0015 kg of Cryptococcus laurentii, 0.0015 kg of Wickham's yeast, and 0.0015 kg of Candida boidinii to the plant extract, keeping the temperature at 35° C., and fermenting for 6.5 days to obtain a fermentation liquid.

[0045] Step 3), the fermentation liquid is filtered through a 0.22 μm filter membrane for sterilization, and after sterilization, it is concentrated to a paste by rotary evaporation, the rotary evaporation pressure is 0.01 MPa, and the rotary evaporation temperature is 60° C., and then the paste is sprayed with powder and dried to obtain an acne-removing composition for fading acne marks.

[0046] Olive leaf extract was purchased from Shaanxi Junhe Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0047] The Phellodendron chinense bark extract was purchased from Shanghai Songhao Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0048] Artemisia annua extract was purchased from Gansu Yishengxiang Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0049] Podocarpus macrophylla extract was purchased from Gansu Yishengxiang Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0050] The hydrolyzed Opuntia cactus flower extract was purchased from Guangzhou Bisheng Trading Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0051] Milk thistle extract was purchased from Shandong Aicai Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0052] Butanediol is commercially available, CAS number: 110-63-4.

[0053] Cryptococcus laurensis was purchased from Beijing Biobio Biotech Co., Ltd., platform number: Bio-76080.

[0054] Abnormal Wickham yeast was purchased from Beijing Bio-Bowei Biotechnology Co., Ltd., platform number: Bio-65131.

[0055] Candida boidinii was purchased from Beijing Biobio Biotech Co., Ltd., platform number: Bio-53361.

[0056] Example 3 An acne-removing composition for fading acne marks, and a preparation method of the acne-removing composition for fading acne marks comprises the following steps: Step 1), 1kg of olive leaf extract, 1kg of Phellodendron chinense bark extract, 1kg of Artemisia annua extract, 0.6kg of Podocarpus macrophylla extract, 0.3kg of hydrolyzed Opuntia ficus-indica flower extract, 0.3kg of Milk thistle extract, 30kg of butylene glycol, and 70kg of deionized water are put into a fermentation tank, the speed is 120r / min, stirred for 15-20min, and mixed evenly to obtain a plant extract.

[0057] Step 2), adding 0.002 kg of Cryptococcus laurentii, 0.002 kg of Wickham's yeast, and 0.002 kg of Candida boidinii to the plant extract, keeping the temperature at 36° C. and fermenting for 7 days to obtain a fermentation liquid.

[0058] Step 3), the fermentation liquid is filtered through a 0.22 μm filter membrane for sterilization, and after sterilization, it is concentrated to a paste by rotary evaporation, the rotary evaporation pressure is 0.01 MPa, and the rotary evaporation temperature is 60° C., and then the paste is sprayed with powder and dried to obtain an acne-removing composition for fading acne marks.

[0059] Olive leaf extract was purchased from Shaanxi Junhe Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0060] The Phellodendron chinense bark extract was purchased from Shanghai Songhao Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0061] Artemisia annua extract was purchased from Gansu Yishengxiang Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0062] Podocarpus macrophylla extract was purchased from Gansu Yishengxiang Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0063] The hydrolyzed Opuntia cactus flower extract was purchased from Guangzhou Bisheng Trading Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0064] Milk thistle extract was purchased from Shandong Aicai Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0065] Butanediol is commercially available, CAS number: 110-63-4.

[0066] Cryptococcus laurensis was purchased from Beijing Biobio Biotech Co., Ltd., platform number: Bio-76080.

[0067] Abnormal Wickham yeast was purchased from Beijing Bio-Bowei Biotechnology Co., Ltd., platform number: Bio-65131.

[0068] Candida boidinii was purchased from Beijing Biobio Biotech Co., Ltd., platform number: Bio-53361.

[0069] Comparative Example 1 An acne-removing composition for fading acne marks, which is different from Example 2 only in that: The olive leaf extract was replaced with an equal amount of purslane extract.

[0070] Purslane extract was purchased from Lanzhou Waterless Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0071] Comparative Example 2 An acne-removing composition for fading acne marks, which is different from Example 2 only in that: Replace the Phellodendron bark extract with an equal amount of chamomile extract.

[0072] Chamomile extract was purchased from Gansu Yishengxiang Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0073] Comparative Example 3 An acne-removing composition for fading acne marks, which is different from Example 2 only in that: An equal amount of the Artemisia annua extract was replaced with the Centella asiatica extract.

[0074] Centella asiatica extract was purchased from Shaanxi Tianshengyuan Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0075] Comparative Example 4 An acne-removing composition for fading acne marks, which is different from Example 2 only in that: An equal amount of lavender extract was used to replace the Podocarpus extract.

[0076] Lavender extract was purchased from Shaanxi New Horizon Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0077] Comparative Example 5 An acne-removing composition for fading acne marks, which is different from Example 2 only in that: The hydrolyzed Opuntia ficus-indica flower extract was replaced with an equal amount of Calendula officinalis flower extract.

[0078] Calendula officinalis extract was purchased from Shanyang Lianfeng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0079] Comparative Example 6 An acne-removing composition for fading acne marks, which is different from Example 2 only in that: Replace the milk thistle extract with an equal amount of rosemary extract.

[0080] Rosemary extract was purchased from Lanzhou Waterless Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0081] Comparative Example 7 An acne-removing composition for fading acne marks, which is different from Example 2 only in that: An equal amount of purslane extract was used to replace the olive leaf extract, an equal amount of chamomile extract was used to replace the phellodendron bark extract, an equal amount of Centella asiatica extract was used to replace the artemisia annua extract, an equal amount of lavender extract was used to replace the Podocarpus macrophylla extract, an equal amount of calendula officinalis extract was used to replace the hydrolyzed opuntia flower extract, and an equal amount of rosemary extract was used to replace the milk thistle extract.

[0082] Purslane extract was purchased from Lanzhou Waterless Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0083] Chamomile extract was purchased from Gansu Yishengxiang Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0084] Centella asiatica extract was purchased from Shaanxi Tianshengyuan Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0085] Lavender extract was purchased from Shaanxi New Horizon Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0086] Calendula officinalis extract was purchased from Shanyang Lianfeng Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0087] Rosemary extract was purchased from Lanzhou Waterless Biotechnology Co., Ltd., a water-soluble extract with an extraction ratio of 10:1.

[0088] Comparative Example 8 An acne-removing composition for fading acne marks, which is different from Example 2 only in that: Bacillus megaterium was used to replace Cryptococcus laurentii in equal amounts.

[0089] Bacillus megaterium was purchased from Beijing Biobio Biotech Co., Ltd., platform number: Bio-79864.

[0090] Comparative Example 9 An acne-removing composition for fading acne marks, which is different from Example 2 only in that: Bacillus licheniformis was used to replace the abnormal Wickham yeast in equal amounts.

[0091] Bacillus licheniformis was purchased from Beijing Biobio Biotechnology Co., Ltd., platform number: Bio-74736.

[0092] Comparative Example 10 An acne-removing composition for fading acne marks, which is different from Example 2 only in that: Candida boidinii was replaced with an equal amount of Leuconostoc mesenteroides.

[0093] Leuconostoc mesenteroides was purchased from Beijing Biobio Biotech Co., Ltd., platform number: Bio-77149.

[0094] Comparative Example 11 An acne-removing composition for fading acne marks, which is different from Example 2 only in that: Bacillus megaterium was used to replace Cryptococcus laurentii in equal amounts, Bacillus licheniformis was used to replace Wickham's yeast in equal amounts, and Leuconostoc mesenteroides was used to replace Candida boidinii in equal amounts.

[0095] Bacillus megaterium was purchased from Beijing Biobio Biotech Co., Ltd., platform number: Bio-79864.

[0096] Bacillus licheniformis was purchased from Beijing Biobio Biotechnology Co., Ltd., platform number: Bio-74736.

[0097] Leuconostoc mesenteroides was purchased from Beijing Biobio Biotech Co., Ltd., platform number: Bio-77149.

[0098] Experiment 1 The anti-acne compositions for fading acne marks of the embodiments and comparative examples were used to prepare test samples for efficacy testing.

[0099] Preparation of the sample to be tested: 3.9 g of the anti-acne composition for fading acne marks, 20 g of butylene glycol, and 76.1 g of deionized water were mixed evenly to obtain the sample to be tested.

[0100] Butanediol is commercially available, CAS number: 110-63-4.

[0101] Recruit a number of volunteers aged 25-35 years old, with at least 2 acne on the face, in groups of 10. Before using the test sample, the volume of acne, skin color of acne area (red-green value) a * Value, facial red area percentage, and transepidermal water loss TEWL test.

[0102] After using the test sample for 7, 14, and 28 days, the acne volume and skin color (red-green value) of the acne area were tested again. * The facial red area ratio was measured, and the transepidermal water loss rate TEWL was tested again after using the test sample for 14 and 28 days.

[0103] Transepidermal water loss rate TEWL test: using the multi-probe skin testing system CK-Tewameter TM Hex, the lower the test value, the lower the skin water loss rate.

[0104] Proportion of facial red area: Using facial image analyzer VISIA-CR, the lower the test value, the lower the proportion of skin red area.

[0105] Acne volume: Using PRIMOS-CR, the lower the test value, the smaller the acne volume.

[0106] Acne area skin color (red-green value)a * Value: The selected acne area is photographed using the Antera 3D Skin Imager. The lower the test value, the less red the skin color.

[0107] During the experiment, the test sample was used once in the morning and once in the evening. Each time, clean the face with clean water and a disposable face washcloth. After drying the water, take 3 ml of the test sample and apply it evenly on the face.

[0108] During the experiment, no other skin care products were used except the test samples.

[0109] The specific test data of Experiment 1 are shown in Tables 1-4.

[0110] Table 1 Changes in the proportion of red area on the face Table 2 Changes in acne volume Table 3 Acne area a * Value Change Table 4 Changes in skin transepidermal water loss rate According to the data comparison of each embodiment and comparative example in Tables 1-4, each embodiment reduces the red area of ​​the face significantly faster than each comparative example, and each embodiment reduces the volume of acne significantly faster than each comparative example. * The speed of reducing the transepidermal water loss rate of each embodiment is significantly higher than that of each comparative example. It can be seen that each embodiment can eliminate acne more quickly and reduce acne marks in acne areas, and at the same time can eliminate skin redness more quickly, and can establish a skin barrier more quickly, can achieve the effect of quickly removing acne and fading acne marks, can repair the skin well, keep the skin healthy, and reduce the recurrence of acne.

[0111] In comparative examples 1-7, other plant extracts with acne-removing effects are used to replace the olive leaf extract, yellow bark tree extract, Artemisia annua extract, Podocarpus extract, hydrolyzed prickly pear cactus flower extract, and milk thistle extract in the examples, and in comparative examples 8-11, other fermentation bacteria are used to replace the Cryptococcus laurentii, Wickham yeast, and Candida boidinii in the examples, either alone or in whole.

[0112] However, the comparison ratios were significantly lower in reducing the red area of ​​the face, reducing the volume of acne, and reducing the acne area. * The value and the speed of reducing the transepidermal water loss rate are significantly worse than those in the embodiments. It can be seen that when the olive leaf extract, the yellow bark tree extract, the artemisia annua extract, the podocarpus extract, the hydrolyzed prickly pear cactus flower extract, and the milk thistle extract are compounded and fermented with a composite bacteria formed by compounding Cryptococcus laurensis, Wickham yeast, and Candida boidinii, the prepared acne-removing composition for fading acne marks can play a good synergistic role due to the mutual cooperation of various special active substances and fermentation products, thereby significantly improving the effect of removing acne and fading acne marks, especially the quick effect, which can well meet the needs of consumers.

[0113] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. An anti-acne composition for fading acne marks, characterized in that: The acne-removing composition for fading acne marks comprises a compound of olive leaf extract, phellodendron chinense bark extract, artemisia annua extract, podocarpus macrophylla extract, hydrolyzed opuntia cactus flower extract and milk thistle extract.

2. The acne-removing composition for fading acne marks according to claim 1, characterized in that: The mass ratio of the olive leaf extract, the pomelo bark extract, the artemisia annua extract, the podocarpus extract, the hydrolyzed opuntia cactus flower extract and the milk thistle extract is 0.9-1: 0.9-1: 0.9-1: 0.5-0.6: 0.2-0.3: 0.2-0.

3.

3. The acne-removing composition for fading acne marks according to claim 2, characterized in that: The olive leaf extract, the yellow pine bark extract, the artemisia annua extract, the podocarpus extract, the hydrolyzed opuntia cactus flower extract, and the milk thistle extract are all water-soluble extracts.

4. A method for preparing the anti-acne composition for fading acne marks according to any one of claims 1 to 3, characterized in that: The following steps are involved: Step 1), olive leaf extract, yellow pine bark extract, artemisia annua extract, Podocarpus macrophylla extract, hydrolyzed opuntia cactus flower extract, milk thistle extract, and solvent are mixed evenly to obtain a plant extract; Step 2), adding composite bacteria to the plant extract for fermentation to obtain a fermentation liquid; Step 3), sterilizing the fermented liquid, concentrating and drying it to obtain an acne-removing composition for fading acne marks; The composite bacteria is a combination of Cryptococcus laurentii, Wickham's yeast and Candida boidinii.

5. The method for preparing an anti-acne composition for fading acne marks according to claim 3, characterized in that: In the composite bacteria, the mass ratio of Cryptococcus laurentii, Wickhamella anomala and Candida boidinii is 0.001-0.002:0.001-0.002:0.001-0.

002.

6. The method for preparing the anti-acne composition for fading acne marks according to claim 5, characterized in that: The solvent is a compound of butanediol and deionized water.

7. The method for preparing the anti-acne composition for fading acne marks according to claim 6, characterized in that: The mass ratio of the butanediol to the deionized water is 20-30:70-80.

8. The method for preparing the anti-acne composition for fading acne marks according to claim 7, characterized in that: In the step 1), the mass ratio of olive leaf extract, phellodendron chinense bark extract, artemisia annua extract, podocarpus macrophylla extract, hydrolyzed opuntia cactus flower extract, milk thistle extract and solvent is 0.9-1: 0.9-1: 0.9-1: 0.5-0.6: 0.2-0.3: 0.2-0.3: 20-25.

9. The method for preparing an anti-acne composition for fading acne marks according to claim 8, characterized in that: In the step 2), the mass ratio of the plant extract to the composite bacteria is 23.6-29.2:0.003-0.

006.

10. The method for preparing an anti-acne composition for fading acne marks according to claim 4, characterized in that: In the step 2), during fermentation, the fermentation temperature is 34-36° C. and the fermentation time is 6-7 days.

Images