Composition with anti-wrinkle effect as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of cosmetics, and discloses a composition with an anti-wrinkle effect and a preparation method and application thereof. The composition disclosed by the invention is prepared from the following components: methylsilanol mannuronate, acetyl hexapeptide-8, a sparassis crispa extract and a hollyhock flower extract. According to the composition disclosed by the invention, the methylsilanol mannuronate, the acetyl hexapeptide-8, the sparassis crispa (SPARASSIS CRISPA) extract and the althaea rosea (ALTHAEA ROSEA) flower extract are compounded, and the four components are mutually matched to play a synergistic effect, so that not only can the self anti-oxidation effect be enhanced, but also the cell stability can be maintained, the elasticity can be enhanced, the wrinkles can be relieved and the wrinkles can be prevented, and the aim of obviously delaying senescence can be achieved.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics, and particularly relates to a composition with anti-wrinkle effect, a preparation method and application thereof. Background Art

[0002] As we age, aging problems are inevitable. The factors affecting aging include endogenous and exogenous factors, which are manifested in: the skin loses elasticity and develops dry lines and fine lines; the skin barrier is damaged and the face becomes red; the skin becomes dull and the pores become enlarged; the facial contour becomes loose, etc.

[0003] At present, there are a variety of anti-aging skin care products on the market, but their functions are relatively simple and the effects are not very ideal. Therefore, it is very necessary to develop an effective anti-wrinkle and anti-aging product. Summary of the invention

[0004] The present invention aims to solve at least one of the technical problems existing in the above-mentioned prior art. To this end, the present invention provides a composition with anti-wrinkle effect and its preparation method and application, which achieves the purpose of anti-wrinkle and anti-aging by stimulating cell renewal, collagen production, increasing elasticity, reducing wrinkles and anti-oxidation.

[0005] The first aspect of the present invention provides a composition, comprising the following components: methylsilanol mannuronate, acetyl hexapeptide-8, hydrangea extract and hibiscus flower extract.

[0006] Specifically, methylsilanol mannuronate, as a combination of silanol and mannuronate of organic silicon, can repair skin, restructure connective tissue, stimulate cell growth, and generate new collagen.

[0007] Specifically, acetyl hexapeptide-8 mimics the N-terminal structure of the SNAP-25 protein, competing with the SNAP-25 protein for its position in the SNARE complex, thereby reducing the formation of the SNARE complex, and then reducing the release of acetylcholine (Ach), achieving the purpose of relaxing muscles. The SNARE complex refers to the process of forming a fusion protein of the neuronal vesicle-associated membrane protein (VAMP) and the SNAP-25 and NMJ fusion proteins after the neuronal vesicles containing acetylcholine (Ach) are stimulated.

[0008] Specifically, Sparassis CRISPA extract is a fungus extract rich in high-molecular polysaccharides, which has the functions of regulating immunity, anti-inflammation, anti-oxidation and anti-radiation. In addition, Sparassis CRISPA contains a large amount of antioxidants, so the extract has a high antioxidant effect and is beneficial for delaying aging.

[0009] Specifically, the main chemical components of hollyhock (ALTHAEA ROSEA) flower extract are flavonoids and flavonoid glycosides; among them, flavonoid glycosides are a very excellent antioxidant ingredient that can help eliminate free radicals and delay aging.

[0010] The composition of the present invention adopts methylsilanol mannuronate, acetyl hexapeptide-8, hydrangea (SPARASSIS CRISPA) extract, and hibiscus (ALTHAEA ROSEA) flower extract. The four cooperate with each other and have a coordinated synergistic effect. They can not only enhance their own antioxidant effect, but also maintain cell stability, enhance elasticity, smooth lines and resist wrinkles, and achieve the purpose of significantly delaying aging.

[0011] In some embodiments of the present invention, the composition comprises the following components, measured by weight: 0.01 to 5 parts of methylsilanol mannuronate, 0.1 to 20 parts of acetyl hexapeptide-8, 0.1 to 20 parts of hydrangea extract and 0.05 to 3 parts of hibiscus flower extract.

[0012] In some embodiments of the present invention, the composition comprises the following components, measured by weight: 0.1 to 5 parts of methylsilanol mannuronate, 0.1 to 15 parts of acetyl hexapeptide-8, 0.5 to 20 parts of hydrangea extract, and 0.1 to 3 parts of hibiscus flower extract.

[0013] In some embodiments of the present invention, the composition comprises the following components, measured by weight: 0.1 to 3 parts of methylsilanol mannuronate, 0.25 to 12 parts of acetyl hexapeptide-8, 0.5 to 10 parts of hydrangea extract, and 0.1 to 1 part of hibiscus flower extract.

[0014] The second aspect of the present invention provides a method for preparing the composition according to the first aspect of the present invention, comprising the following steps:

[0015] The components are mixed to obtain a composition.

[0016] The third aspect of the present invention provides the use of the composition described in the first aspect of the present invention in the preparation of a product, wherein the product has at least one of the effects of anti-wrinkle, anti-oxidation, anti-aging and improving skin elasticity.

[0017] The fourth aspect of the present invention provides a cosmetic comprising the composition described in the first aspect of the present invention.

[0018] In some embodiments of the present invention, the content of the composition in the cosmetic is 0.01 to 50 wt%, preferably 0.1 to 50 wt%; for example, it can be any point value among 0.01 wt%, 0.1 wt%, 1 wt%, 5 wt%, 10 wt%, 20 wt%, 30 wt%, 40 wt%, 50 wt%, or a range value between two arbitrary point values.

[0019] In some embodiments of the present invention, the cosmetic further comprises at least one of a thickener, a moisturizer, a preservative, an emulsifier and an emollient.

[0020] In some embodiments of the present invention, the thickener includes 0.2-0.5 parts of ammonium acryloyldimethyltaurate / VP copolymer and 0.05-0.2 parts of xanthan gum, in parts by mass; the moisturizer includes 0.01-0.1 parts of sodium hyaluronate, 2-8 parts of glycerol, 1-8 parts of butylene glycol, and 0.5-1 parts of 1,2-hexanediol; the preservative includes 0.01-0.5 parts of p-hydroxyacetophenone; the emulsifier includes 1-4 parts of EMULGADE 165CN (glyceryl stearate, PEG-100 stearate), 0.5-2 parts of MONTANOV 6MB (cetearyl alcohol, cetearyl glucoside, glucose, water), and 0.2-1 parts of cetyl palmitate; the emollient includes avocado tree (BUTYROSPERMUM PARKII) fruit butter 1-8 parts, pentaerythritol tetra(ethylhexanoate) 1-4 parts, tri(ethylhexanoin) 1-8 parts, cetearyl alcohol 0.5-2 parts, behenyl alcohol 0.2-2 parts, polydimethylsiloxane 2-10 parts, tocopheryl acetate 0.1-1 parts, polymethylsilsesquioxane 0.1-1 parts.

[0021] In some embodiments of the present invention, the cosmetics include any one of a cleanser, a toner, an essence, an emulsion, a cream, a mask or a foundation.

[0022] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0023] The composition provided by the present invention is compounded by methylsilanol mannuronate, acetyl hexapeptide-8, hydrangea (SPARASSIS CRISPA) extract and hibiscus (ALTHAEA ROSEA) flower extract. The four cooperate with each other to play a coordinated and synergistic role, which can not only enhance the self-antioxidant effect, but also maintain cell stability, enhance elasticity, smooth lines and resist wrinkles, and achieve the purpose of significantly delaying aging. DETAILED DESCRIPTION

[0024] In order to make the technical scheme of the present invention more clearly understood by those skilled in the art, the following embodiments are listed for illustration. It should be pointed out that the following embodiments do not limit the protection scope of the present invention.

[0025] Unless otherwise specified, the raw materials, reagents or devices used in the present invention can be obtained from conventional commercial channels or by existing known methods.

[0026] Example 1

[0027] This example provides a composition, which is composed of 2 parts of methylsilanol mannuronate, 8 parts of acetyl hexapeptide-8, 5 parts of hydrangea (SPARASSIS CRISPA) extract, and 0.8 parts of hibiscus (ALTHAEA ROSEA) flower extract, by weight.

[0028] The preparation method of the composition of this example is: methylsilanol mannuronate, acetyl hexapeptide-8, Sparassis CRISPA extract and Althaea ROSEA flower extract are mixed to prepare the composition.

[0029] Example 2

[0030] This example provides a composition, which is composed of 0.01 parts of methylsilanol mannuronate, 0.1 parts of acetyl hexapeptide-8, 0.1 parts of hydrangea (SPARASSIS CRISPA) extract, and 0.05 parts of hibiscus (ALTHAEA ROSEA) flower extract, by weight.

[0031] Example 3

[0032] This example provides a composition, which is composed of 5 parts of methylsilanol mannuronate, 20 parts of acetyl hexapeptide-8, 20 parts of hydrangea (SPARASSIS CRISPA) extract, and 3 parts of hibiscus (ALTHAEA ROSEA) flower extract, by weight.

[0033] Example 4

[0034] This example provides a composition, which is composed of 3 parts of methylsilanol mannuronate, 8 parts of acetyl hexapeptide-8, 10 parts of hydrangea (SPARASSIS CRISPA) extract, and 1 part of hibiscus (ALTHAEA ROSEA) flower extract, by weight.

[0035] Example 5

[0036] This example provides a composition, which is composed of 2 parts of methylsilanol mannuronate, 15 parts of acetyl hexapeptide-8, 5 parts of hydrangea (SPARASSIS CRISPA) extract, and 0.8 parts of hibiscus (ALTHAEA ROSEA) flower extract, by weight.

[0037] The preparation methods of the compositions of Examples 2 to 5 are the same as that of Example 1.

[0038] Comparative Example 1

[0039] This example provides a composition, the formula of which is basically the same as that of Example 1, except that it does not contain ALTHAEA ROSEA flower extract.

[0040] Comparative Example 2

[0041] This example provides a composition, the formulation of which is substantially the same as that of Example 1, except that it does not contain the Sparassis CRISPA extract.

[0042] Comparative Example 3

[0043] This example provides a composition, the formula of which is basically the same as that of Example 1, except that it does not contain acetyl hexapeptide-8.

[0044] Comparative Example 4

[0045] This example provides a composition, the formulation of which is substantially the same as that of Example 1, except that it does not contain methylsilanol mannuronate.

[0046] Comparative Example 5

[0047] This example provides a composition, the formula of which is basically the same as that of Example 1, except that it does not contain Sparassis CRISPA extract and Althaea ROSEA flower extract.

[0048] Comparative Example 6

[0049] This example provides a composition, the formula of which is basically the same as that of Example 1, except that it does not contain acetyl hexapeptide-8 and hibiscus rosa canina (ALTHAEA ROSEA) flower extract.

[0050] Comparative Example 7

[0051] This example provides a composition, the formula of which is basically the same as that of Example 1, except that it does not contain acetyl hexapeptide-8 and Sparassis CRISPA extract.

[0052] Comparative Example 8

[0053] This example provides a composition, the formula of which is basically the same as that of Example 1, except that it does not contain methylsilanol mannuronate and hibiscus rosa canina (ALTHAEA ROSEA) flower extract.

[0054] Comparative Example 9

[0055] This example provides a composition, the formula of which is basically the same as that of Example 1, except that it does not contain methylsilanol mannuronate and Sparassis CRISPA extract.

[0056] Comparative Example 10

[0057] This example provides a composition, the formula of which is basically the same as that of Example 1, except that it does not contain methylsilanol mannuronate and acetyl hexapeptide-8.

[0058] Comparative Example 11

[0059] This example provides a composition, the formula of which is basically the same as that of Example 1, except that an equal amount of methylsilanol mannuronate is replaced with sodium mannose phosphate of similar efficacy.

[0060] Comparative Example 12

[0061] This example provides a composition, the formula of which is basically the same as that of Example 1, except that an equal amount of acetyl hexapeptide-8 is replaced with a dipeptide diaminobutyryl benzylamide diacetate having similar efficacy.

[0062] Comparative Example 13

[0063] This example provides a composition, the formula of which is basically the same as that of Example 1, except that an equal amount of the Sparassis CRISPA extract is replaced with an Armillaria Matsutake extract having similar efficacy.

[0064] Comparative Example 14

[0065] This example provides a composition, the formula of which is basically the same as that of Example 1, except that an equal amount of hibiscus (ALTHAEAROSEA) flower extract is replaced with an hibiscus (ALTHAEA OFFICINALIS) root extract of similar efficacy.

[0066] Composition efficacy test

[0067] Experimental Example 1 Study on Antioxidant Efficacy—DPPH Free Radical Scavenging Experiment

[0068] Take 1g of the composition of Examples 1 to 5 and Comparative Examples 1 to 14, add 2mL of anhydrous ethanol, and after complete dissolution, add 2mL of 60μmol / L DPPH solution and mix well, let stand for 30min, adjust to zero with anhydrous ethanol, and measure the absorbance at 517nm as Ai; in the same way, take 2mL of anhydrous ethanol solvent + 2mL of DPPH solution and mix well to measure the absorbance as Ac; take 1g of the matrix of the composition and dissolve it, add 2mL of anhydrous ethanol, and then add 2mL of anhydrous ethanol solvent and mix well to measure the absorbance as Aj.

[0069] The free radical scavenging rate was calculated according to the following formula:

[0070] Clearance (%) = [1-(Ai-Aj) / Ac] × 100%;

[0071] Among them, Aj is the contribution of the reaction sample itself to the absorbance; Ai is the absorbance value of the sample after the action of DPPH; Ac is the absorption of DPPH itself at the measurement wavelength.

[0072] The DPPH free radical scavenging rate reflects its antioxidant capacity to a certain extent. The higher the scavenging rate, the better the antioxidant degree and the better the anti-aging effect. Therefore, the anti-aging effect of the composition can be judged by studying its ability to scavenge DPPH free radicals.

[0073] The results are shown in Table 1 (each group of samples was measured 5 times in parallel, and the data are presented as average values).

[0074] Table 1

[0075]

[0076]

[0077] As can be seen from Table 1, the compositions of Examples 1 to 5 have a good scavenging effect on DPPH. The higher the DPPH scavenging rate, the stronger the antioxidant capacity and the better the anti-aging effect. The DPPH scavenging rate of Comparative Examples 1 to 14 is significantly lower than that of Examples 1 to 5, that is, the lack of a single or multiple components in the composition of the present invention, or the replacement of the components in the composition of the present invention with other components, all lead to a significant reduction in the scavenging effect on DPPH, indicating that the methylsilanol mannuronate, acetyl hexapeptide-8, hydrangea extract and hibiscus flower extract in the composition of the present invention are indispensable.

[0078] Experimental Example 2 Metalloproteinase (MMP-1) inhibition experiment

[0079] Test method: Fibroblasts were seeded into 12-well cell culture plates, with each well containing 0.75×10 5Cells were starved in serum-free medium for 24 hours. The starved cells were rinsed with PBS and treated with UV light (40 mJ / cm 2 ). Then, the test sample was added to the cells twice within 48 hours. The MMP-1 isolated in the culture medium was measured using a kit (BIOTRAK RPN2610). The anti-aging ability was evaluated by calculating the inhibition rate of MMP-1 expression.

[0080] The calculation formula is as follows:

[0081] Inhibition rate = (AB) / A × 100%;

[0082] A: The expression level of MMP-1 after UV irradiation without adding the test sample; B: The expression level of MMP-1 after UV irradiation with adding the test sample.

[0083] The results are shown in Table 2.

[0084] Table 2

[0085] Sample name MMP-1 inhibition rate (%) Example 1 72.25 Example 2 70.11 Example 3 70.65 Example 4 71.64 Example 5 70.21 Comparative Example 1 45.23 Comparative Example 2 44.58 Comparative Example 3 45.33 Comparative Example 4 46.32 Comparative Example 5 30.87 Comparative Example 6 32.47 Comparative Example 7 30.12 Comparative Example 8 29.89 Comparative Example 9 30.68 Comparative Example 10 32.24 Comparative Example 11 44.86 Comparative Example 12 44.12 Comparative Example 13 43.88 Comparative Example 14 44.17

[0086] As can be seen from Table 2, the MMP-1 inhibition rate of the compositions of Examples 1 to 5 is significantly higher than that of the compositions of Comparative Examples 1 to 14, indicating that the anti-aging ability of the compositions of Examples 1 to 5 is superior to that of the compositions of Comparative Examples 1 to 14. It can be seen that the lack of a single or multiple components in the composition of the present invention, or the replacement of the components in the composition of the present invention with other components, all lead to a significant decrease in the MMP-1 inhibition rate, indicating that the methylsilanol mannuronate, acetyl hexapeptide-8, hydrangea extract and hibiscus flower extract in the composition of the present invention are synergistic and indispensable.

[0087] Application Examples 1 to 5

[0088] Application Examples 1 to 5 all provide a cream comprising the composition of the present invention, and the formula thereof is shown in Table 3.

[0089] Table 3

[0090]

[0091]

[0092] The preparation method of the cream of Application Examples 1 to 5 is as follows:

[0093] (1) deionized water, glycerin, butylene glycol, sodium hyaluronate, xanthan gum and ammonium acryloyldimethyltaurate / VP copolymer are stirred and dissolved according to a weight ratio, heated to 80° C. to 85° C. and kept warm for 10 min to 15 min to obtain phase A;

[0094] (2) Avocado tree (BUTYROSPERMUM PARKII) fruit fat, pentaerythritol tetra(ethylhexanoate), glyceryl tri(ethylhexanoate), cetearyl alcohol, behenyl alcohol, EMULGADE 165CN (glyceryl stearate, PEG-100 stearate), MONTANOV 6MB (cetearyl alcohol, cetearyl glucoside, glucose, water) and cetyl palmitate are stirred and dissolved according to weight ratio, and heated to 80° C. to 85° C. to obtain phase B1;

[0095] (3) stirring and dispersing polydimethylsiloxane, tocopherol acetate and polymethylsilsesquioxane in a weight ratio to obtain a B2 phase;

[0096] (4) mixing and dissolving 1,2-hexanediol and p-hydroxyacetophenone to obtain phase C;

[0097] (5) Add phase B1 and phase B2 into phase A, stir evenly, homogenize, and keep warm for 5 to 10 minutes; after cooling to 55°C to 60°C, add phase C, stir evenly, and homogenize;

[0098] (6) After the temperature drops to below 45° C., add the following composition by weight: methylsilanol mannuronate, acetyl hexapeptide-8, hydrangea (SPARASSIS CRISPA) extract and hibiscus (ALTHAEA ROSEA) flower extract, and continue stirring until the temperature drops to below 38° C. to obtain a cream.

[0099] Application Comparative Example 1

[0100] The difference between Application Comparative Example 1 and Application Example 1 is that, in Application Comparative Example 1, methylsilanol mannuronate is not added, and other components, dosages and preparation methods are the same as those in Application Example 1.

[0101] Application Comparative Example 2

[0102] The difference between Application Comparative Example 2 and Application Example 1 is that Application Comparative Example 2 does not add acetyl hexapeptide-8, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0103] Application Comparative Example 3

[0104] The difference between Application Comparative Example 3 and Application Example 1 is that Application Comparative Example 3 does not add Sparassiscrista extract, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0105] Application Comparative Example 4

[0106] The difference between Application Comparative Example 4 and Application Example 1 is that Application Comparative Example 4 does not add hibiscus (ALTHAEAROSEA) flower extract, and other components, addition amounts and preparation methods are the same as those of Application Example 1.

[0107] Application Comparative Example 5

[0108] The difference between Application Example 5 and Application Example 1 is that Application Example 5 does not add acetyl hexapeptide-8, hydrangea extract and hibiscus flower extract, and other components, addition amounts and preparation methods are the same as those in Application Example 1.

[0109] Application Comparative Example 6

[0110] The difference between Application Comparative Example 6 and Application Example 1 is that Application Comparative Example 6 does not add methylsilanol mannuronate, hydrangea extract and hibiscus flower extract, and other components, addition amounts and preparation methods are the same as those in Application Example 1.

[0111] Application Comparative Example 7

[0112] The difference between Application Example 7 and Application Example 1 is that Application Example 7 does not add methylsilanol mannuronate, acetyl hexapeptide-8 and hibiscus flower extract, and other components, addition amounts and preparation methods are the same as those in Application Example 1.

[0113] Application Comparative Example 8

[0114] The difference between Application Comparative Example 8 and Application Example 1 is that Application Comparative Example 8 does not add methylsilanol mannuronate, acetyl hexapeptide-8 and hydrangea extract, and other components, addition amounts and preparation methods are the same as those in Application Example 1.

[0115] Application Comparative Example 9

[0116] The difference between Application Comparative Example 9 and Application Example 1 is that Application Comparative Example 9 does not add hydrangea extract and hibiscus flower extract, and other components, addition amounts and preparation methods are the same as those in Application Example 1.

[0117] Application Comparative Example 10

[0118] The difference between Application Comparative Example 10 and Application Example 1 is that no composition is added in Application Comparative Example 10, and other components, addition amounts and preparation methods are the same as those in Application Example 1.

[0119] Cream efficacy test

[0120] Test Example 3 Skin Elasticity Test

[0121] This test is conducted on the skin elasticity test of the creams of Application Examples 1 to 5 and Application Comparative Examples 1 to 10.

[0122] A total of 150 volunteers aged between 18 and 45 were recruited, and the experimental design was randomized, double-blind, and historically controlled. The volunteers were randomly divided into 15 groups, 10 in each group, and the creams of application examples 1 to 5 and comparative examples 1 to 10 were tested respectively. The volunteers used the product on their faces once in the morning and evening every day. Before use and on the 7th day after use, at a temperature of 21±1°C and a humidity of 50±10%, the volunteers cleaned their faces and waited for 20 minutes before testing the elasticity (R2 value).

[0123] Elasticity (R2 value) change rate: refers to the change rate of skin elasticity after using the product compared to before use. A positive value means that the ratio of the maximum stretch displacement of the skin increases, and the skin elasticity is better; a negative value means that the ratio of the maximum stretch displacement of the skin decreases, and the skin elasticity is worse.

[0124] The test results are shown in Table 4.

[0125] Table 4

[0126]

[0127]

[0128] As can be seen from Table 4, the creams prepared in Application Examples 1 to 5 with the composition of the present invention can greatly improve skin elasticity and help delay aging. The creams prepared without the composition of the present invention or lacking one or more components of the composition of the present invention (Application Comparative Examples 1 to 10) have a significantly reduced effect on improving skin elasticity, indicating that the methylsilanol mannuronate, acetyl hexapeptide-8, hydrangea extract and hibiscus flower extract in the composition of the present invention have synergistic effects and none of them can be missing.

[0129] Test Example 4 Anti-wrinkle test

[0130] This test is conducted on the anti-wrinkle efficacy of the creams of Application Examples 1 to 5 and Application Comparative Examples 1 to 10.

[0131] A total of 150 volunteers aged between 18 and 45 were recruited, and the experimental design was randomized, double-blind, and historically controlled. The volunteers were randomly divided into 15 groups, 10 in each group, and the creams of application examples 1 to 5 and application comparative examples 1 to 10 were tested respectively. The volunteers used the product on their faces once in the morning and evening every day. Before use (D0), on the 14th day after use (D14), and on the 28th day after use (D28), at a temperature of 21±1°C and a humidity of 50±10%, the volunteers cleaned their faces and waited for 20 minutes, then used VISIA7 to take facial photos, and measured the number (lines) of wrinkles around the eyes and the total area of ​​wrinkles on the face.

[0132] Wrinkle number (bar) value change rate: refers to the change rate of the number of wrinkles (bars) around the eyes after using the product compared to before use. A positive value indicates an increase in the number of wrinkles around the eyes, and more wrinkles around the eyes; a negative value indicates a decrease in the number of wrinkles around the eyes, and fewer wrinkles around the eyes.

[0133] Total wrinkle area value change rate: refers to the change rate of the total area of ​​wrinkles around the eyes after using the product compared to before use. A positive value means that the total area of ​​wrinkles around the eyes increases, and there are more wrinkles around the eyes; a negative value means that the total area of ​​wrinkles around the eyes decreases, and there are fewer wrinkles around the eyes.

[0134] Test result analysis:

[0135] (1) The analysis results of the wrinkle number (line) value are shown in Table 5; (2) The analysis results of the total wrinkle area value are shown in Table 6.

[0136] Table 5

[0137]

[0138]

[0139]

[0140] As can be seen from Table 5, the creams prepared in Application Examples 1 to 5 with the addition of the composition of the present invention can greatly reduce the growth of the number of wrinkles around the eyes. The creams prepared without the addition of the composition of the present invention, or lacking one or more components of the composition of the present invention (Application Comparative Examples 1 to 10), resulted in a less than ideal effect of reducing the growth of the number of wrinkles around the eyes.

[0141] Table 6

[0142]

[0143]

[0144]

[0145] As can be seen from Table 6, the creams prepared in Application Examples 1 to 5 with the addition of the composition of the present invention can greatly reduce the total area value of periocular wrinkles. The creams prepared without the addition of the composition of the present invention or lacking one or more components of the composition of the present invention (Application Comparative Examples 1 to 10) result in a less than ideal effect of reducing the total area value of periocular wrinkles.

[0146] Based on the analysis of the test results of (1) and (2) of the above-mentioned Test Example 4, it can be concluded that the composition of the present invention is compounded by the four components of methylsilanol mannuronate, acetyl hexapeptide-8, hydrangea (SPARASSIS CRISPA) extract and hibiscus (ALTHAEA ROSEA) flower extract, which has a synergistic effect and has excellent wrinkle-soothing and anti-wrinkle effects.

[0147] The preferred embodiments of the present invention are specifically described above, but the invention is not limited to the embodiments. Those skilled in the art can make various equivalent modifications or substitutions without violating the spirit of the invention. These equivalent modifications or substitutions are all included in the scope defined by the claims of this application.

Claims

1. A composition, characterized in that The composition comprises the following components: methylsilanol mannuronate, acetyl hexapeptide-8, hydrangea extract and hibiscus flower extract.

2. The composition according to claim 1, characterized in that The composition comprises the following components in parts by mass: 0.01 to 5 parts of methylsilanol mannuronate, 0.1 to 20 parts of acetyl hexapeptide-8, 0.1 to 20 parts of hydrangea extract and 0.05 to 3 parts of hibiscus flower extract.

3. The composition according to claim 2, characterized in that The composition comprises the following components in parts by mass: 0.1 to 5 parts of methylsilanol mannuronate, 0.1 to 15 parts of acetyl hexapeptide-8, 0.5 to 20 parts of hydrangea extract, and 0.1 to 3 parts of hibiscus flower extract.

4. The composition according to claim 3, characterized in that The composition comprises the following components in parts by mass: 0.1 to 3 parts of methylsilanol mannuronate, 0.25 to 12 parts of acetyl hexapeptide-8, 0.5 to 10 parts of hydrangea extract, and 0.1 to 1 part of hibiscus flower extract.

5. The method for preparing the composition according to any one of claims 1 to 4, characterized in that: The following steps are involved: The components are mixed to obtain a composition.

6. Use of the composition according to any one of claims 1 to 4 in preparing a product, characterized in that: The product has at least one of the effects of anti-wrinkle, anti-oxidation, anti-aging and improving skin elasticity.

7. A cosmetic, characterized in that: A composition comprising any one of claims 1 to 4.

8. The cosmetic according to claim 7, characterized in that: The content of the composition is 0.01-50 wt %.

9. The cosmetic according to claim 7, characterized in that: The cosmetic may further include at least one of a thickener, a moisturizer, a preservative, an emulsifier, and an emollient.

10. The cosmetic according to claim 7, characterized in that: The cosmetics include any one of cleansing lotion, toner, essence, emulsion, cream, facial mask or liquid foundation.

Images