Traditional Chinese medicine composition with effects of promoting blood circulation to remove blood stasis and warming and activating meridians as well as preparation method, application and product of traditional Chinese medicine composition

Abstract

The invention provides a traditional Chinese medicine composition with the effects of promoting blood circulation to remove blood stasis and warming and activating meridians as well as a preparation method, application and a product thereof, and relates to the technical field of traditional Chinese medicine compositions. The traditional Chinese medicine composition is prepared from the following components: radix angelicae sinensis, pollen typhae, radix linderae, rhizoma chuanxiong, radix paeoniae rubra, rhizoma corydalis, caulis spatholobi, fructus foeniculi and ramulus cinnamomi. The preparation method comprises the following steps: (1) taking angelica sinensis, pollen typhae, lindera aggregata, ligusticum wallichii, radix paeoniae rubra, corydalis tuber, caulis spatholobi, fennel and cassia twig, adding water, and decocting to obtain a decoction for later use; (2) filtering the decoction in the step (1), combining filtrates, and concentrating to obtain clear paste for later use; and (3) adding dextrin into the clear paste obtained in the step (2), uniformly mixing, and drying to obtain the traditional Chinese medicine composition. The traditional Chinese medicine composition obtained by adopting the components and the preparation method disclosed by the invention has the advantages of easily available raw materials, low price, no additive, low cost, no toxic or side effect, simple preparation method and obvious effects of promoting blood circulation to remove blood stasis and warming and activating meridians.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition having the effects of promoting blood circulation and removing blood stasis, warming meridians and dredging collaterals, and a preparation method, application and product thereof. Background Art

[0002] Studies have shown that 90% of patients who come to see their period have symptoms of dysmenorrhea, and cold blood stasis, qi stagnation and blood stasis, damp-heat accumulation, yang deficiency and internal cold, qi and blood deficiency, and liver and kidney deficiency, among which cold blood stasis, qi stagnation and blood stasis, and yang deficiency and internal cold are the main causes of dysmenorrhea. In traditional Chinese medicine theory, blood stasis refers to the state in which blood is not smoothly retained in the meridians, forming an accumulation or coagulation. Activating blood circulation and removing blood stasis refers to the process of promoting blood circulation, regulating and dissipating blood stasis, and making blood flow unobstructed. Activating blood circulation and removing blood stasis is applicable to a wide range of conditions, such as chest tightness, heart pain, and blue lips caused by blood stasis in the heart; chest pain and coughing caused by blood stasis in the lungs; flank pain and lumps caused by blood stasis in the liver; lower abdominal pain, irregular menstruation, and dysmenorrhea caused by blood stasis in the uterus; local swelling, pain, and cyanosis caused by blood stasis in the limbs; hemiplegia caused by blood stasis in the veins, etc. The treatment method of promoting blood circulation and removing blood stasis is usually used in combination with the methods of invigorating qi, nourishing blood, warming the meridians and dispelling cold, clearing heat, promoting qi, and attacking the lower part. The commonly used prescriptions are composed of drugs such as Chuanxiong, peach kernel, safflower, red peony root, salvia miltiorrhiza, pollen, frankincense, and myrrh. Representative prescriptions include Taoren Chengqi Decoction, Xuefu Zhuyu Decoction, Fuyuan Huoxue Decoction, and Wenjing Decoction.

[0003] For example, patent CN 110787253 A discloses a formula and preparation method of a traditional Chinese medicine hot compress bag for relieving dysmenorrhea, including main ingredients and auxiliary ingredients. The main ingredients include the following traditional Chinese medicine ingredients in parts by weight: mugwort leaf: 10-30 parts; angelica root: 10-30 parts; chuanxiong: 10-30 parts; white peony root: 10-30 parts; processed cyperus rotundus: 10-30 parts; cinnamon bark: 5-15 parts; cassia twig: 10-30 parts; evodia rutaecarpa: 5-15 parts; lindera striata: 10-30 parts; fennel: 10-30 parts; cloves: 10-30 parts; yanhusuo: 10-30 parts; auxiliary ingredients include the following ingredients in parts by weight: mugwort leaf charcoal: 10-30 parts; pig iron powder: 10-30 parts; Bianstone powder: 10-30 parts; salt: 10-30 parts; absorbent resin fine powder: 10-30 parts. The invention uses traditional Chinese medicine to regulate and treat dysmenorrhea, and is combined with a traditional Chinese medicine hot compress pack to relieve dysmenorrhea as an auxiliary treatment, which can help improve the treatment effect and shorten the treatment time. Another example is a pill medicine for treating qi stagnation and blood stasis type dysmenorrhea provided by patent CN 107582965 A. The components of the medicine and their weight ratios are as follows: 30-100g of epimedium, 30-100g of lithospermum, 30-100g of polygala, 30-100g of corydalis, 80-180g of angelica, 100-180g of motherwort, 60-180g of selfheal, 30-100g of bupleurum, 90-350g of astragalus, 30-100g of fructus aurantii, 100-350g of prepared rehmannia, 30-120g of dried tangerine peel, 15-80g of cassia twig. 0g, Cornus officinalis 50-120g, Ligustrum lucidum 80-160g, Pollen 50-120g, Sanguisorba officinalis 10-15g, Curcuma 80-160g, Red Peony 60-150g, Ophiopogon japonicus 30-100g, Rose 300-700g, Cyperus rotundus 80-160g, Corydalis 80-160g, Fennel 30-70g, Salvia miltiorrhiza 80-160g, Chuanxiong 50-120g, Millettia reticulata 150-280g, Tripterygium wilfordii 50-120g, Licorice 30-150g. The drugs provided by these two patents are both very good Chinese medicine prescriptions, but they have too many components, and from the perspective of economic benefits, they are not the first choice of manufacturers.

[0004] For another example, patent CN 103251751B discloses a traditional Chinese medicine composition for treating primary dysmenorrhea, which is made of the following raw materials in parts by weight: 100-300 parts of Corydalis yanhusuo, 100-300 parts of angelica sinensis, 100-200 parts of ligusticum chuanxiong, 100-300 parts of lindera stalk, 100-200 parts of evodia rutaecarpa and 100-300 parts of pollen. The preparation steps include: (1) weighing the raw materials; (2) extracting the volatile oils of angelica, chuanxiong, lindera stalks, and evodia rutaecarpa with water, encapsulating the volatile oils with beta-cyclodextrin to obtain volatile oil inclusion compounds, and preparing the water extract and the residues; (3) extracting yanhusuo and the residues with ethanol, and preparing the alcohol extract; (4) sterilizing, drying, and crushing pollen typhae; (5) concentrating the water extract and the alcohol extract under reduced pressure; (6) mixing the water extract concentrate with 3 / 4 pollen typhae and drying to obtain a water extract dry paste; (7) mixing the alcohol extract concentrate with 1 / 4 pollen typhae and drying to obtain an alcohol extract dry paste; (8) mixing the water extract dry paste, the alcohol extract dry paste, and the volatile oil inclusion compounds, crushing, shaping, and preparing the preparation. The Chinese medicine composition of the invention has the advantages of definite efficacy, concise drug ratio, small dosage, good efficacy, small side effects, convenient administration, and abundant drug sources. Although the Chinese medicine composition of the invention has few ingredients, its preparation process is too complicated.

[0005] Therefore, there is an urgent need to develop a Chinese medicine composition with few ingredients, simple preparation method and good effects of promoting blood circulation, removing blood stasis, warming meridians and dredging collaterals, as well as its preparation method, application and product. Summary of the invention

[0006] Based on the deficiencies of the prior art, the present invention aims to provide a Chinese medicine composition with few ingredients, simple preparation method and good effects of promoting blood circulation and removing blood stasis, warming meridians and unblocking collaterals, and its preparation method and application. The ingredients contained in the method are angelica, pollen, lindera, ligusticum chuanxiong, red peony root, corydalis, millettia, fennel and cassia twig. After reasonable preparation and scientific formulation, the Chinese medicine composition has good effects of promoting blood circulation and removing blood stasis through experiments.

[0007] In order to achieve the above object, the present invention adopts the following technical solutions:

[0008] On the one hand, the present invention provides a traditional Chinese medicine composition with the effects of promoting blood circulation and removing blood stasis, warming the meridians and dredging collaterals. The traditional Chinese medicine composition specifically comprises the following components in parts by weight: 265-400 parts of angelica sinensis, 200-300 parts of pollen, 400-600 parts of lindera stalks, 130-200 parts of ligusticum chuanxiong, 265-400 parts of red peony root, 130-200 parts of corydalis yanhusuo, 330-500 parts of millettia reticulata, 65-100 parts of fennel and 200-300 parts of cassia twig.

[0009] Preferably, the Chinese medicine composition comprises the following components by weight: 300-370 parts of Angelica sinensis, 225-275 parts of Pollen Typhae, 450-550 parts of Linderae strychnifolia, 150-185 parts of Ligusticum chuanxiong, 300-370 parts of Red Peony Root, 150-185 parts of Corydalis yanhusuo, 375-460 parts of Millettia reticulata, 75-90 parts of fennel and 225-275 parts of cassia twig.

[0010] More preferably, the Chinese medicine composition comprises the following components in parts by weight: 333 parts of Angelica sinensis, 250 parts of Pollen Typhae, 500 parts of Linderae strychnifolia, 167 parts of Ligusticum chuanxiong, 333 parts of Paeonia lactiflora, 167 parts of Corydalis yanhusuo, 417 parts of Millettia reticulata, 83 parts of fennel and 250 parts of cassia twig.

[0011] The mechanism of selecting each component in the present invention is:

[0012] Angelica sinensis (Oliv.) Diels, a plant of the Umbelliferae family, is a dried root. It is harvested in late autumn, the fibrous roots and sand are removed, and after the water evaporates slightly, it is bundled into small bundles, put on a shed, and slowly smoked dry with fireworks. It can nourish blood and invigorate blood circulation, regulate menstruation and relieve pain, and moisten the intestines and promote bowel movements. It is used for blood deficiency and chlorosis, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to deficiency and cold, rheumatic arthralgia, injuries from falls, carbuncles and ulcers, and constipation due to dry intestines.

[0013] Angelica sinensis is pungent, sweet and warm in nature and can move through the blood, replenish blood, activate blood circulation, regulate menstruation and relieve pain. It is the main ingredient in the prescription.

[0014] Typha angustifolia L, Typha orientalis Presl or the dried pollen of Typha angustifolia L, Typha orientalis Presl or the same genus. In summer, the yellow male inflorescence on the upper part of the cattail is harvested, dried in the sun, and crushed to sieve the pollen. It can stop bleeding, dissipate blood stasis, and relieve stranguria. It is used for hematemesis, epistaxis, hemoptysis, metrorrhagia, traumatic bleeding, amenorrhea, dysmenorrhea, chest and abdominal stabbing pain, swelling and pain from falls, and bloody stranguria. Lindera aggregata (Sims) Kos-term, a dried root of Lindera aggregata (Sims) Kos-term, a plant of the Lauraceae family. It can be dug up all year round, the fine roots are removed, washed, sliced ​​while fresh, and dried in the sun, or directly dried in the sun. It can promote qi circulation and relieve pain, warm the kidney and dispel cold. It is used for cold stagnation and qi stagnation, chest and abdominal distension and pain, qi reversal and shortness of breath, bladder deficiency and coldness, enuresis and frequent urination, hernia pain, and abdominal pain due to cold menstruation.

[0015] Puhuang can remove blood stasis and stop bleeding, promote blood circulation and relieve pain, while Wuyao can warm the kidney, dispel cold and relieve pain. The two medicines assist the main organ and serve as the ministers.

[0016] Chuanxiong, the dried rhizome of the plant Ligusticum chuanxiong Hort of the Umbelliferae family. It is dug up in summer when the nodes on the stem are prominent and slightly purple, and the sand is removed. It is dried in the sun and then the fibrous roots are removed. It promotes blood circulation and qi, dispels wind and relieves pain. It is used for chest pain, heart pain, chest and rib pain, swelling and pain due to falls, irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to lumps, headache, and rheumatic pain. Red peony root, the dried root of the plant Paeonia lactiflora Pall or Paeonia veitchii Lynch of the Ranunculaceae family. It is dug up in spring and autumn, the rhizome, fibrous roots and sand are removed, and it is dried in the sun. It clears heat and cools blood, dispels blood stasis and relieves pain. Used for heat entering into the blood, fever and toxicity causing spots, vomiting blood and bleeding, red and swollen eyes, liver depression and flank pain, amenorrhea and dysmenorrhea, abdominal pain due to lumps and masses, injuries from falls, carbuncle and ulcer; Corydalis yanhusuo, the dried tuber of the poppy family Corydalis yanhusuo (WTWang). Dig it up in early summer when the stems and leaves wither, remove the fibrous roots, wash it, boil it in boiling water or steam it until there is just no white heart, take it out and dry it in the sun. It can promote blood circulation, promote qi circulation and relieve pain. It can be used for chest and flank, abdominal pain, chest obstruction and heart pain, amenorrhea and dysmenorrhea, postpartum blood stasis, and swelling and pain due to falls; Millettia reticulata, the dried vine stem of the leguminous plant Spatholobus suberectus Dunn. Harvested in autumn and winter, remove the branches and leaves, slice it and dry it in the sun. It can promote blood circulation and replenish blood, regulate menstruation and relieve pain, and relax muscles and activate collaterals. Used for irregular menstruation, dysmenorrhea, amenorrhea, rheumatic arthralgia, numbness and paralysis, and chlorosis due to blood deficiency; fennel, the dried mature fruit of the Umbelliferae plant Foeniculum vulgare Mill. The plant is cut when the fruit is just ripe in autumn, dried, and the fruit is beaten and impurities are removed. It dispels cold and relieves pain, regulates qi and harmonizes the stomach. It is used for abdominal pain caused by cold hernia, testicular prolapse, dysmenorrhea, cold pain in the lower abdomen, abdominal distension and pain, and loss of appetite and vomiting and diarrhea.

[0017] Chuanxiong, red peony root, and Corydalis yanhusuo promote blood circulation and remove blood stasis, promote qi and relieve pain, Millettia reticulata replenishes blood and promotes blood circulation, unblocks menstruation and activates collaterals, fennel regulates qi and harmonizes the stomach, dispels cold and relieves pain, and serves as an adjuvant to the monarch and minister.

[0018] Cinnamon twig is the dried young branch of Cinnamomum cassia Presl. It is harvested in spring and summer, leaves are removed, and dried in the sun, or sliced ​​and dried in the sun. It can induce sweating and relieve muscle pain, warm and dredge the meridians, help yang and transform qi, and balance and descend qi. It is used for colds, cold pain in the abdomen, amenorrhea due to cold blood, joint pain, phlegm and fluid retention, edema, palpitations, and running pig.

[0019] Cinnamon twig warms and dredges the meridians, helps yang and transforms qi, and can be used as an adjuvant. All the medicines are used together to promote blood circulation, remove blood stasis, warm the meridians and dredge the collaterals.

[0020] On the other hand, the present invention also provides the above-mentioned Chinese medicine composition having the effects of promoting blood circulation and removing blood stasis, warming meridians and unblocking collaterals and a preparation method thereof, comprising the following steps:

[0021] (1) Take Chinese angelica, pollen, lindera striata, ligusticum chuanxiong, red peony root, yanhusuo, millettia reticulata, fennel and cassia twig, add water and boil to obtain a decoction, which is set aside;

[0022] (2) filtering the decoction in step (1), combining the filtrate, and concentrating the decoction to obtain a clear paste for later use;

[0023] (3) Add dextrin to the clear paste obtained in step (2), mix well, and dry to obtain a Chinese medicine composition.

[0024] Preferably, the number of decoctions in the above step (1) is 1-3 times, more preferably 2 times.

[0025] Preferably, the decocting time in the above step (1) is 1-2 hours, more preferably 1.5 hours.

[0026] Preferably, the mass ratio of the material to the liquid in the above step (1) is 1:7-11; further preferably, the mass ratio of the material to the liquid in the first water addition is 1:10; and even more preferably, the mass ratio of the material to the liquid in the second water addition is preferably 1:8.

[0027] Preferably, the concentration method in the above step (2) is concentration under reduced pressure.

[0028] Preferably, the relative density of the clear paste in the above step (2) is 1.05-1.10.

[0029] Preferably, the dextrin in the above step (3) is added twice, the first addition amount of dextrin is 5% of the total mass of all components of the traditional Chinese medicine composition, and the second addition amount of dextrin is 1%-10% of the total mass of all components of the traditional Chinese medicine composition.

[0030] More preferably, the amount of dextrin added for the second time is 8% of the total mass of all components of the traditional Chinese medicine composition.

[0031] Preferably, the drying in the above step (3) is spray drying, and the inlet air temperature of the spray drying is 175°C-185°C, and the outlet air temperature is 85°C-95°C.

[0032] More preferably, the drying in the above step (3) is spray drying, and the inlet air temperature of the spray drying is 185°C and the outlet air temperature is 85°C.

[0033] In another aspect, the present invention also provides the use of the above-mentioned Chinese medicine composition with the effects of promoting blood circulation and removing blood stasis, warming the meridians and dredging collaterals in the preparation of drugs for promoting blood circulation and removing blood stasis, warming the meridians and dredging collaterals.

[0034] The dosage form of the product is granules, tablets, capsules or oral liquid.

[0035] Compared with the prior art, the present invention has the following beneficial effects:

[0036] (1) It is made from Chinese medicine with readily available and inexpensive raw materials, has no additives, is low cost and has no toxic side effects.

[0037] (2) The operation is simple and feasible, and the product quality is controllable.

[0038] (3) Experiments have shown that the Chinese medicine composition has obvious effects in treating dysmenorrhea and promoting blood circulation and removing blood stasis. DETAILED DESCRIPTION

[0039] The present invention is further described in detail below with reference to specific embodiments.

[0040] Example 1 A Chinese medicine composition having the effects of promoting blood circulation and removing blood stasis, warming the meridians and dredge collaterals, and its preparation method

[0041] The Chinese medicine composition specifically comprises the following components by weight:

[0042] 333 parts of Chinese Angelicae Sinensis, 250 parts of Pollen Typhae, 500 parts of Linderae Atractylodes, 167 parts of Ligusticum chuanxiong, 333 parts of Red Peony Root, 167 parts of Corydalis Scutellariae, 417 parts of Millettia Spatholobi, 83 parts of Foeniculum Vulgare and 250 parts of Cinnamomum cassia.

[0043] The preparation method specifically comprises the following steps:

[0044] (1) Take Chinese Angelica, Pollen Typhae, Linderae Root, Ligusticum chuanxiong, Paeonia lactiflora, Corydalis yanhusuo, Millettia reticulata, Fennel, and Cinnamon Twig, add water and boil twice, add 10 times the amount of water for the first time and boil for 1.5 hours, add 8 times the amount of water for the second time and boil for 1.5 hours to obtain a decoction, which is set aside;

[0045] (2) filtering the decoction in step (1), combining the filtrate, and concentrating under reduced pressure to a clear paste with a relative density of 1.05-1.10 (60° C.), and setting aside;

[0046] (3) Add dextrin to the clear paste obtained in step (2), wherein the amount of dextrin added is 5% of the total mass of all components of the above-mentioned traditional Chinese medicine composition, mix well, spray dry, and then add dextrin again, wherein the amount of dextrin added for the second time is 8% of the total mass of all components of the above-mentioned traditional Chinese medicine composition, and make granules to obtain the traditional Chinese medicine composition.

[0047] The inlet air temperature of the spray drying is 185℃ and the outlet air temperature is 85℃.

[0048] Example 2 A Chinese medicine composition having the effects of promoting blood circulation and removing blood stasis, warming the meridians and dredge collaterals, and its preparation method

[0049] The Chinese medicine composition specifically comprises the following components by weight:

[0050] 265 parts of Chinese Angelicae Sinensis, 300 parts of Pollen Typhae, 400 parts of Linderae Radix, 200 parts of Ligusticum chuanxiong, 265 parts of Red Peony Root, 200 parts of Corydalis Scutellariae, 330 parts of Millettia Spatholobi, 100 parts of Foeniculum Vulgare, and 200 parts of Cinnamomum Cassiae.

[0051] The preparation method is different from that in Example 1 only in that the water decoction in step (1) is performed once, the mass ratio of water to liquid is 1:7, and the time is 1 h. In step (3), the amount of dextrin added for the second time is 1% of the mass of all components of the above-mentioned traditional Chinese medicine composition, the drying inlet air temperature is 175°C, and the drying outlet air temperature is 85°C. The other steps are consistent with Example 1.

[0052] Example 3 A Chinese medicine composition having the effects of promoting blood circulation and removing blood stasis, warming the meridians and unblocking collaterals and its preparation method

[0053] The Chinese medicine composition specifically comprises the following components by weight:

[0054] 400 parts of Chinese Angelicae Sinensis, 200 parts of Pollen Typhae, 600 parts of Linderae Radix, 130 parts of Ligusticum chuanxiong, 400 parts of Red Peony Root, 130 parts of Corydalis Scutellariae, 500 parts of Millettia Spatholobi, 65 parts of Foeniculum Vulgare, and 300 parts of Cinnamomum Cassiae.

[0055] The preparation method is different from that in Example 1 only in that the water addition and decoction in step (1) is performed three times, the mass ratio of the material to the liquid in the third water addition is 1:11, the time is 2 h, the amount of dextrin added for the second time in step (3) is 10% of the mass of all components of the above-mentioned traditional Chinese medicine composition, the drying air inlet temperature is 185° C., the drying air outlet temperature is 95° C., and the other steps are consistent with Example 1.

[0056] Example 4 A Chinese medicine composition having the effects of promoting blood circulation and removing blood stasis, warming the meridians and dredge collaterals, and its preparation method

[0057] The Chinese medicine composition specifically comprises the following components by weight:

[0058] 300 parts of Chinese Angelicae Sinensis, 225 parts of Pollen Typhae, 550 parts of Linderae Radix, 150 parts of Ligusticum chuanxiong, 370 parts of Red Peony Root, 185 parts of Corydalis Scutellariae, 460 parts of Millettia Spatholobi, 75 parts of Foeniculum Vulgare, and 275 parts of Cinnamomum Cassiae.

[0059] The preparation method is consistent with that in Example 1.

[0060] Example 5 A Chinese medicine composition having the effects of promoting blood circulation and removing blood stasis, warming the meridians and dredge collaterals, and its preparation method

[0061] The Chinese medicine composition specifically comprises the following components by weight:

[0062] 370 parts of Radix Angelicae Sinensis, 275 parts of Pollen Typhae, 450 parts of Linderae Radix, 185 parts of Rhizoma Chuanxiong, 300 parts of Red Peony Root, 150 parts of Corydalis Scutellariae, 375 parts of Millettia Spatholobi, 90 parts of Fennel, and 225 parts of Cinnamomum Cinnamomum.

[0063] The preparation method is consistent with that in Example 1.

[0064] Comparative Example 1

[0065] The difference between Comparative Example 1 and Example 1 is that the total mass of the Chinese medicine composition is the same but the mass of each component is different. The Chinese medicine composition is specifically composed of the following components by weight: 238 parts of Angelica sinensis, 159 parts of Pollen Typhae, 595 parts of Linderae strychnifolia, 167 parts of Ligusticum chuanxiong, 333 parts of Paeonia lactiflora, 238 parts of Corydalis yanhusuo, 437 parts of Millettia reticulata, 83 parts of fennel, and 250 parts of cassia twig.

[0066] The preparation method is consistent with that in Example 1.

[0067] Comparative Example 2

[0068] The difference between Comparative Example 2 and Example 1 is that Millettia reticulata is replaced by Myrrha. The Chinese medicine composition specifically comprises the following components by weight: 333 parts of Angelica sinensis, 250 parts of Pollen Typhae, 500 parts of Linderae strychnifolia, 167 parts of Ligusticum chuanxiong, 333 parts of Paeonia lactiflora, 167 parts of Corydalis yanhusuo, 417 parts of Myrrha, 83 parts of Fennel, and 250 parts of Cinnamomum cassia.

[0069] The preparation method is different from that of Example 1 only in step (1). Specifically, (1) taking Chinese angelica, pollen, lindera strychnifolia, chuanxiong, red peony root, corydalis, myrrh, fennel and cassia twig, adding water and boiling for 2 times, adding 10 times the amount of water for the first time and boiling for 1.5 hours, and adding 8 times the amount of water for the second time and boiling for 1.5 hours to obtain a decoction for later use. The other steps are the same as those of Example 1.

[0070] Comparative Example 3

[0071] The difference between Comparative Example 3 and Example 1 is that cassia twig is replaced by cinnamon bark. The Chinese medicine composition specifically comprises the following components by weight: 333 parts of angelica sinensis, 250 parts of pollen, 500 parts of lindera striata, 167 parts of chuanxiong, 333 parts of red peony root, 167 parts of yanhusuo, 417 parts of millettia reticulata, 83 parts of fennel, and 250 parts of cinnamon bark.

[0072] The preparation method is different from that of Example 1 only in step (1). Specifically, (1) taking Chinese angelica, pollen, lindera strychnifolia, chuanxiong, red peony root, corydalis, myrrh, fennel and cinnamon, adding water and boiling for 2 times, adding 10 times the amount of water for the first time and boiling for 1.5 hours, and adding 8 times the amount of water for the second time and boiling for 1.5 hours to obtain a decoction for later use. The other steps are the same as those of Example 1.

[0073] Comparative Example 4

[0074] The difference between Comparative Example 4 and Example 1 is that Puhuang replaces Panax notoginseng. The Chinese medicine composition specifically comprises the following components by weight: 333 parts of Angelica sinensis, 250 parts of Panax notoginseng, 500 parts of Linderae strychnifolia, 167 parts of Chuanxiong, 333 parts of Red Peony Root, 167 parts of Corydalis yanhusuo, 417 parts of Millettia reticulata, 83 parts of fennel, and 250 parts of cinnamon.

[0075] The preparation method is different from that of Example 1 only in step (1). Specifically, (1) taking Chinese Angelica, Panax notoginseng, Linderae rutaecarpa, Ligusticum chuanxiong, Paeonia lactiflora, Corydalis yanhusuo, Myrrha, Fennel, and Cinnamon, adding water and boiling for 2 times, adding 10 times the amount of water for the first time and boiling for 1.5 hours, and adding 8 times the amount of water for the second time and boiling for 1.5 hours to obtain a decoction for later use. The other steps are the same as those of Example 1.

[0076] Comparative Example 5

[0077] At present, the closest prior art CN 110787253A has been retrieved, in which 3 ingredients of the present invention are not disclosed by CN110787253A, and 6 ingredients are disclosed. The difference between Comparative Example 5 and Example 1 is only the different ingredients, which are specifically the following components by weight: Artemisia argyi: 30 parts; Angelica sinensis: 30 parts; Chuanxiong: 30 parts; White peony root: 30 parts; Processed Cyperus rotundus: 30 parts; Cinnamon bark: 15 parts; Cinnamon twig: 30 parts; Evodia rutaecarpa: 15 parts; Linderae strychnos: 30 parts; Fennel: 30 parts; Cloves: 30 parts; Corydalis yanhusuo: 30 parts.

[0078] The preparation method is different from that of Example 1 only in step (1). Specifically, (1) taking Artemisia argyi, Chinese angelica, Chuanxiong, white peony root, processed Cyperus rotundus, cinnamon bark, cassia twig, Evodia rutaecarpa, Linderae striata, cumin, clove and Corydalis yanhusuo, adding water and boiling for 2 times, adding 10 times the amount of water for the first time and boiling for 1.5 hours, and adding 8 times the amount of water for the second time and boiling for 1.5 hours to obtain a decoction for later use. The other steps are the same as those of Example 1.

[0079] Effect test:

[0080] Experimental methods

[0081] SPF grade Kunming mice, weighing 18-20g, female non-pregnant. According to body weight, they were randomly divided into blank control group, model group, embodiment 1-5 group, comparative example 1-5 group, 8 in each group. The model of primary dysmenorrhea in mice was replicated by combining estradiol benzoate and oxytocin. The specific scheme is: the blank group mice were subcutaneously injected with 10mL / kg of normal saline, and the remaining groups of mice were subcutaneously injected with equal volumes of estradiol benzoate for 10 consecutive days, wherein the injection dose on the 1st and 10th days was 5mg / kg, and the injection dose on the 2nd-9th days was 2.5mg / kg. From the 4th day, the embodiment group and the comparative example group were gavaged with the corresponding composition, with a dosage of 15g crude drug / kg and a dosage volume of 20mL / kg, for 7 consecutive days, and the model group and the blank group were gavaged with equal volumes of normal saline. 1h after the last administration, 20U / kg oxytocin was injected intraperitoneally. The latency and number of writhing times of the mice were observed within 30 minutes (abdomen contracted and concave, trunk and hind limbs extended, buttocks and one side of the limbs rotated internally). The latency period without writhing reaction was counted as 30 minutes.

[0082] Experimental Results

[0083] The experimental results are shown in Table 1 below.

[0084] Table 1 Twist latency and number of twists of each embodiment and comparative example

[0085] Group Writhing latency (minutes) Number of twists (times) Blank control group 30 0 Model Group <![CDATA[2.94±1.08 ** ]]> <![CDATA[31.25±4.95 ** ]]> Example 1 Group <![CDATA[8.85±3.19 # ]]> <![CDATA[8.72±1.02 ## ]]> Example 2 Group <![CDATA[7.27±2.85 # ]]> <![CDATA[12.86±1.25 ## ]]> Example 3 Group <![CDATA[7.45±2.77 # ]]> <![CDATA[13.17±1.16 ## ]]> Example 4 Group <![CDATA[7.68±3.54 # ]]> <![CDATA[10.45±1.08 ## ]]> Example 5 Group <![CDATA[7.79±2.36 # ]]> <![CDATA[10.59±1.13 ## ]]> Comparative Example 1 <![CDATA[6.18±2.11 #△ ]]> <![CDATA[16.22±1.56 #△ ]]> Comparative Example 2 <![CDATA[5.83±1.79 #△ ]]> <![CDATA[17.38±1.47 #△ ]]> Comparative Example 3 <![CDATA[5.96±2.05 #△ ]]> <![CDATA[16.64±1.85 #△ ]]> Comparative Example 4 <![CDATA[5.65±1.98 #△ ]]> <![CDATA[17.91±2.21 #△ ]]> Comparative Example 5 <![CDATA[5.50±1.82 #△ ]]> <![CDATA[19.03±2.42 #△ ]]>

[0086] Note: Compared with the blank control group, **P<0.01; compared with the model group, #P<0.05, ##P<0.01; compared with the Example 1 group, △P<0.05.

[0087] Experimental analysis

[0088] It can be seen from Examples 1-5 that Example 1 has the longest torsion latency and the least torsion times, which indicates that the quality of the components of the Chinese medicine composition in Example 1 and its preparation method are the best for treating dysmenorrhea.

[0089] It can be seen from Comparative Example 1 that the weight percentages of the components of the traditional Chinese medicine composition must be within the scope of the present invention in order to achieve a better effect in treating dysmenorrhea.

[0090] It can be seen from Comparative Examples 2-4 that replacing the monarch drug, the guiding drug and the adjuvant drug in Example 1 can reduce the effect of treating dysmenorrhea, which illustrates the necessity of using the components of the Chinese medicine composition of the present invention, and the monarch, the guiding drug and the adjuvant drug have synergistic effects.

[0091] It can be seen from Comparative Example 5 that its effect in treating dysmenorrhea is weaker than that of the present invention, which shows that only using the components of the present invention can achieve the effect of promoting blood circulation and removing blood stasis, treating dysmenorrhea, and the effect is better.

[0092] In summary, the Chinese medicine composition obtained by using the components and portions described in the present invention has a synergistic effect of the monarch, minister, assistant and envoy, so as to achieve a better effect of promoting blood circulation and removing blood stasis.

[0093] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features may be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A Chinese medicine composition having the effects of promoting blood circulation and removing blood stasis, warming the meridians and dredging collaterals, characterized in that: The Chinese medicine composition specifically comprises the following components by weight: 265-400 parts of angelica sinensis, 200-300 parts of pollen, 400-600 parts of lindera stalk, 130-200 parts of ligusticum chuanxiong, 265-400 parts of red peony root, 130-200 parts of corydalis yanhusuo, 330-500 parts of millettia reticulata, 65-100 parts of fennel and 200-300 parts of cassia twig.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition specifically comprises the following components by weight: 300-370 parts of angelica sinensis, 225-275 parts of pollen, 450-550 parts of lindera strychnifolia, 150-185 parts of ligusticum chuanxiong, 300-370 parts of red peony root, 150-185 parts of corydalis yanhusuo, 375-460 parts of millettia reticulata, 75-90 parts of fennel and 225-275 parts of cassia twig.

3. The Chinese medicine composition according to claim 1, characterized in that The Chinese medicine composition specifically comprises the following components by weight: 333 parts of angelica sinensis, 250 parts of pollen pollen, 500 parts of lindera stalk, 167 parts of ligusticum chuanxiong, 333 parts of red peony root, 167 parts of yanhusuo, 417 parts of millettia reticulata, 83 parts of fennel and 250 parts of cassia twig.

4. The method for preparing the Chinese medicine composition according to any one of claims 1 to 3, characterized in that: The steps include: (1) Take Chinese angelica, pollen, lindera striata, chuanxiong, red peony root, yanhusuo, millettia reticulata, fennel and cinnamon twig, add water and boil to obtain a decoction, which is set aside; (2) filtering the decoction in step (1), combining the filtrate, and concentrating the decoction to obtain a clear paste for later use; (3) Add dextrin to the clear paste obtained in step (2), mix well, and dry to obtain a Chinese medicine composition.

5. The preparation method according to claim 4, characterized in that: The decoction in step (1) is performed 1-3 times, with a material-liquid mass ratio of 1:7-11, and the decoction time is 1-2 hours.

6. The preparation method according to claim 4, characterized in that: The relative density of the clear paste in step (2) at 60° C. is 1.05-1.

10.

7. The preparation method according to claim 4, characterized in that: The dextrin in step (3) is added twice, the first addition amount of dextrin is 5% of the total mass of all components of the traditional Chinese medicine composition, and the second addition amount of dextrin is 1%-10% of the total mass of all components of the traditional Chinese medicine composition.

8. The preparation method according to claim 4, characterized in that: The drying in step (3) is spray drying, the air inlet temperature of the spray drying is 175°C-185°C, and the air outlet temperature of the spray drying is 85°C-95°C.

9. Use of the Chinese medicine composition according to any one of claims 1 to 3 in the preparation of blood circulation-activating and blood stasis-removing, meridian-warming and collateral-dredging drugs.

10. A product for promoting blood circulation and removing blood stasis, warming the meridians and dredge collaterals, characterized by: The Chinese medicine composition comprises any one of claims 1 to 3, wherein the dosage form of the product is granules, tablets, capsules or oral liquids.