Ametoctradin and oxine-copper compounded pesticide suspending agent

Abstract

The invention provides an ametoctradin and oxine-copper compounded pesticide suspending agent. The active ingredients of the suspending agent comprise ametoctradin and oxine-copper, the active component accounts for 7.5 wt%-65 wt% of the suspending agent; wherein the content of ametoctradin in the suspending agent is 5wt%-30wt%, and the content of oxine-copper in the suspending agent is 2.5 wt%-35wt%; and the balance of auxiliaries and water. In addition, the invention further provides a preparation method and application of the ametoctradin and oxine-copper compounded pesticide suspending agent, the suspending agent is effective for preventing and treating cucumber downy mildew, and experiments prove that the compounded suspending agent has more obvious effect than a single component of ametoctradin and a single component of oxine-copper in the aspect of preventing and treating cucumber downy mildew.

Description

Technical Field

[0001] The invention belongs to the technical field of pesticides, and in particular relates to a fungicide composition resistant to cucumber downy mildew, and more particularly to a pesticide suspension prepared by compounding pyraclostrobin and quinoline copper. Background Art

[0002] Cucumber downy mildew, also known as dew fungus, commonly known as running dry, black hair, plague, etc., is a disease caused by infection of Cuban pseudoperonospora and occurs on cucumbers. It mainly harms leaves, but can also harm stems and inflorescences, and can occur from seedling stage to adult stage. When the disease occurs, it is often applied by spraying medicine. Common antibacterial and fungicidal drugs for cucumber downy mildew include carbendazim, mancozeb, thiophanate-methyl, etc. However, the above drugs have a high residual rate and residual toxicity, and repeated use will also cause drug resistance problems.

[0003] Azopyraclostrobin is a highly selective fungicide that can effectively and flexibly control downy mildew and late blight. The product has the advantages of being resistant to rain erosion, being able to redistribute in leaves, protecting the healthy growth of crops, and giving full play to growth potential. Azopyraclostrobin is a QoSI fungicide, and its mechanism of action is that it binds to the Qo-distal site on the bc1 complex (complex III) on the mitochondria, blocking the electron transfer of the respiratory electron transport chain. The problem of drug resistance of this type of fungicide is also very prominent, which can easily cause rapid mutation of the strain.

[0004] Quinoline copper is a quinoline protective low-toxic fungicide. Quinoline copper has a broad spectrum, high efficiency, low residue, and is safe to use. It has good preventive and therapeutic effects on fungal and bacterial diseases. The molecule of quinoline copper is a clamp-like structure, and quinolinic acid can clamp copper ions and release them slowly and safely. After spraying, a tight protective film is formed on the surface of the plant, which has a strong affinity with the plant and is resistant to rain erosion; the film slowly releases bactericidal copper ions, effectively inhibiting the germination and invasion of pathogens, thereby achieving the purpose of disease prevention and treatment. Compared with commonly used drugs such as carbendazim, quinoline copper has greater advantages: ① Quinoline copper has the characteristics of broad spectrum, high efficiency, low toxicity, and low residue; ② Quinoline copper has a longer lasting effect, which can be up to 15 days; ③ Quinoline copper is safer, does not stimulate leaf fall, and protects leaves and fruits. It is safe and reliable to use in the young leaves and young fruits, and has the effect of promoting growth.

[0005] Commonly used 33.5% quinoline copper suspension. However, quinoline copper belongs to a high-salt system, and its single agent and compound water suspension are prone to heat storage paste, agglomeration and other phenomena. In addition, quinoline copper original drug has a high specific gravity, and its suspension is more likely to have a large amount of water precipitation. Quinoline copper is used alone in EC to treat cucumber downy mildew. 50 EC of carbendazim 50It is many times higher, showing the defects of large dosage, high cost and poor effect. In compound drugs, quinoline copper cannot be mixed with strong acid and alkaline pesticides or agents containing other metal ions, and it will also produce antagonism when mixed with carbendazim, greatly reducing the antibacterial and bactericidal effect.

[0006] Through research, our company has combined the highly effective drug pyraclostrobin against cucumber downy mildew with the broad-spectrum antibiotic quinoline copper, and clinical trials have confirmed that this compound formula has a good antibacterial effect on cucumber downy mildew, and the problem of drug resistance has also been controlled to a better extent. Summary of the invention

[0007] The purpose of the present invention is to provide a pesticide with better antibacterial and bactericidal effects on cucumber downy mildew, which solves the problem of rapid development of resistance to the control agent of pyraclostrobin on the one hand; on the other hand, solves the stability problems of quinoline copper suspension such as easy bottoming and severe water precipitation; and thirdly, obtains a pesticide with better control effect on cucumber downy mildew.

[0008] To achieve the above object, the present invention adopts the following technical solution:

[0009] A pesticide suspension prepared by compounding pyraclostrobin and quinoline copper, wherein the active ingredients of the suspension include pyraclostrobin and quinoline copper; the proportion of the active ingredients in the suspension is 7.5wt%-65wt%; wherein the content of pyraclostrobin in the suspension is 5wt%-30wt%, and the content of quinoline copper in the suspension is 2.5wt%-35wt%; and the balance is auxiliary agent and dispersion medium.

[0010] Preferably, the dispersion medium is water, which may be softened water or deionized water. The amount of the dispersion medium is not less than 30 wt%.

[0011] Preferably, the mass ratio of the pyraclostrobin to the quinoline copper is 2:1 to 1:2.

[0012] Furthermore, the mass ratio of the pyraclostrobin to the quinoline copper is 1:1.

[0013] Preferably, the active ingredient accounts for 20 wt% to 60 wt% of the suspending agent, and the remainder is auxiliary agent and water.

[0014] Furthermore, the active ingredient accounts for 40wt% to 50wt% of the suspending agent, and the remainder is auxiliary agent and water.

[0015] Preferably, the particle size (D 90 )≤3.0μm.

[0016] Preferably, the pH value of the suspending agent is 5.0-8.0, and more preferably the pH value is 5.0-6.0.

[0017] Preferably, the auxiliary agent includes at least one of a wetting and dispersing agent, an antifreeze agent, a thickener, a preservative, a defoaming agent, and a pH regulator.

[0018] Preferably, the proportion of the wetting and dispersing agent to the suspending agent is 3wt% to 14wt%. The wetting and dispersing agent is a nonionic hydrophilic polymer dispersant and / or an anionic wetting and dispersing agent; preferably includes a block polyether polymer and / or a comb polymer. Wherein:

[0019] The nonionic polymer wetting and dispersing agent is selected from: at least one of SP-SC3, SP-2836, SP-3060, SP-SC29, SP-2728, SP-28F, SP-21R, SP-2845W, YUS-FS7PG, Agrilan-755, 500HQ, tristyrylphenol polyoxyethylene rice phosphate, cardanol polyoxyethylene ether phosphate, STEPSPERSE-3000 (polymethyl methacrylate-polyethylene glycol graft copolymer), and EO / PO polyether dispersant D-800.

[0020] The anionic hydrophilic wetting and dispersing agent is selected from: at least one of lignin sulfonate, naphthalene sulfonate, dodecyl polyoxyethylene ether phosphate, dodecylphenol polyoxyethylene ether, nonylphenol polyoxyethylene ether, lauryl alcohol polyoxyethylene ether sodium sulfate, D-251, PS-b-PDMS, YUS-SXC, YUS-TXC, YUS-LXC, Morwet EFW, Morwet D-360, Morwet D-390, Morwet D-400, and Morwet D-425 (alkyl naphthalene sulfonate formaldehyde condensate).

[0021] Preferably, the pH value of the suspension is achieved by adding the pH adjuster, and the pH adjuster is selected from at least one of citric acid-sodium citrate buffer and ammonium sulfate.

[0022] Preferably, the defoamer is preferably a non-silicone polyether defoamer, preferably at least one of a silicone defoamer, a block polyether defoamer, a polyether defoamer, and a non-ionic defoamer; more preferably at least one of a non-silicone block polyether defoamer, a non-silicone polyether defoamer, and a non-ionic defoamer. Specifically, it can be selected from: at least one of polydimethylsiloxane, propylene glycol block polyether L61, EO / EP, PPG, and AEO. Preferably, the defoamer accounts for 0.5wt% to 1.5wt% of the suspending agent.

[0023] Preferably, the preservative is at least one of BIT, formic acid, benzoic acid and its salts, propionic acid, sorbic acid and its salts. The proportion of the preservative to the suspending agent is 0.1 wt% to 1 wt%.

[0024] Preferably, the antifreeze agent is at least one of propylene glycol, ethylene glycol, glycerol, polyethylene glycol, urea, sorbitol, and calcium chloride. The proportion of the antifreeze agent to the suspending agent is 1 wt% to 6 wt%.

[0025] Preferably, the thickener is selected from at least one of sodium alginate, xanthan gum, magnesium aluminum silicate, sodium carboxymethyl cellulose, and propylene glycol alginate. The proportion of the thickener to the suspending agent is 0.05wt% to 1.5wt%.

[0026] The present invention also provides a method for preparing the suspension:

[0027] (1) After weighing the wetting and dispersing agent, first disperse and dissolve it with a small amount of water, such as mixing and dispersing it according to the mass ratio of the wetting and dispersing agent to water of 1:1 to 1:2; adding a portion of the wetting and dispersing agent mixed solution, about 30wt% to 50wt% of the total amount, into water as a suspending agent dispersion medium, stirring and shearing to disperse it uniformly, to obtain a mixed solution I;

[0028] (2) weighing the preservative, antifreeze agent and defoaming agent, adding them to the mixed solution I, stirring and shearing to disperse them uniformly, and obtaining a mixed solution II;

[0029] (3) adding the jet-crushed pyraclostrobin technical and quinoline copper technical to the mixed solution II in batches, and high-speed shearing, wherein the high-speed shearing rate is preferably 15000±1000 rpm, and the high-speed shearing is performed for at least 5 minutes to obtain a mixed solution III;

[0030] (4) weighing the thickener and mixing it with a small amount of water to disperse it, such as mixing the thickener and water at a mass ratio of 1:1 to 1:2, and high-speed shearing to obtain a thickener mixed solution;

[0031] (5) Place the mixed solution III in a sand mill and grind it to D using zirconium beads of 0.4 mm to 0.7 mm. 98 ≤7.0μm, add the thickener mixture, grind and mix for a certain time, such as not less than 5min; then add the remaining wetting and dispersing agent mixture into the sand mill once or in batches, add softened water to 100wt%, and grind to D with 0.1mm~0.2mm zirconium beads. 98 ≤5.0μm, the suspension is obtained.

[0032] Preferably, the particle size of the active ingredient in the suspension is D 90 ≤3.0μm.

[0033] The present invention also provides the use of the pesticide suspension prepared by compounding the above-mentioned pyraclostrobin and quinoline copper, and the suspension can be used for preventing and controlling cucumber downy mildew.

[0034] Furthermore, the preferred dosage of the suspension is 40-75 ml / mu under the preferred ratio. The preferred ratio refers to the case where the amount of the active ingredient accounts for 40wt%-50wt% of the suspension, and the ratio of pyraclostrobin to quinoline copper in the active ingredient is 2:1-1:2.

[0035] The advantages of the present invention are:

[0036] (1) The bactericidal mechanism of pyraclostrobin is to inhibit mitochondrial respiration, while the bactericidal mechanism of quinoline copper is to chelate copper and slowly release copper ions to inhibit the RNA-related DNA synthase of pathogens. The two active ingredients have different mechanisms of action. The combined use of the two is not easy to produce drug resistance and has better efficacy and longer duration of efficacy.

[0037] (2) By compounding the active ingredients and adjusting the formula, the stability of quinoline copper in the suspension is enhanced and it is not easy to form a bottom, which is beneficial for the storage of the drug in different environments and prolongs the shelf life of the drug.

[0038] (3) The film formed by quinoline copper in sunlight and weakly acidic water medium is more dense and stable, and is more conducive to the dissociation of copper ions. On the one hand, the precipitation of copper ions is conducive to enhancing the bactericidal activity and the duration of bactericidal effect. Secondly, the quinoline group after the dissociation of copper ions is electronegative. We believe that the electronegative quinoline group will attract the electron density around the amino group on pyraclostrobin, thereby affecting the electronic properties and reaction activity of the amino group on pyraclostrobin, so that pyraclostrobin has a certain repulsive effect on the binding of pyraclostrobin to the Qo site on the mitochondria, thereby making pyraclostrobin show a longer-lasting antibacterial effect than its single agent, and also reducing the resistance of pathogens to pyraclostrobin.

[0039] Definition of terms: (1) The terms “above”, “below”, “within”, etc. are understood to include the number itself, for example, more than two means ≥ two. (2) The term “and / or” is understood to mean any one of the optional items or a combination of any two or more of the optional items. (3) The term “wt%” means weight percentage; the term “%vol” means volume percentage. (4) The term “multiple” means at least two. (5) The term “room temperature” means ambient temperature, generally 20℃ to 30℃ or 25℃. DETAILED DESCRIPTION

[0040] In order to make those skilled in the art better understand the technical solution of the present invention, some non-limiting embodiments are disclosed below to further illustrate the present invention in detail. It should be noted that the embodiments disclosed below are only preferred solutions, some test examples, some embodiments, and some comparative examples of the invention, and are not the entire contents of the present invention. Various reagents in the following embodiments and test examples are all purchased from the market.

[0041] Test Example 1:

[0042] This test example is to screen multiple groups of wetting and dispersing agents by flow point test method, and the preferred combinations are listed as reference examples. In the test example, each group of wetting and dispersing agents is prepared into an aqueous solution in proportion, and then 6.25g of pyraclostrobin technical and 6.25g of quinoline copper technical are added to 50ml solution and dispersed and stirred, and then the flow point value test is performed (Table 1); and the state of the solution at room temperature, hot storage (54℃, 14d), cold storage (0℃, 7d), and freeze-thaw (4℃, 18h~0℃, 6h, 4 cycles) is analyzed (Table 2).

[0043] Table 1 Flow point test values ​​of wetting and dispersing agents (combination)

[0044]

[0045] Table 2 Physical properties test of wetting and dispersing agent (combination)

[0046]

[0047]

[0048] Note: “+” means qualified; “-” means poor fluidity, and the sedimentation rate does not exceed 30%; “--” means poor fluidity, and the sedimentation rate does not exceed 50%; “×” means serious bottom adhesion.

[0049] Comparative group 1 is a single substance of a nonionic high molecular polymer wetting and dispersing agent; comparative group 2 is a single substance of an anionic wetting and dispersing agent; and test groups A1 to A14 are a combination of a nonionic high molecular polymer wetting and dispersing agent and an anionic wetting and dispersing agent.

[0050] It can be seen from the test results in Table 1 that the flow point value of the combined wetting and dispersing agents is generally slightly larger than that of the wetting and dispersing agents of a single substance. However, after hot storage, cold storage and freeze-thaw, by observing the changes in the physical sedimentation of the solution, it can be seen that the effect of the combined wetting and dispersing agents is significantly better than that of a single substance as a wetting and dispersing agent.

[0051] From the results in Table 2, it can be seen that test group A1, test group A2, test group A6, test group A7, test group A13 and test group A14 are relatively more advantageous. However, no antifreeze was added in this test. The inventors subsequently proved through experiments that adding an appropriate amount of antifreeze to test groups A1 to A14 has a better effect.

[0052] Test Example 2:

[0053] In order to further understand and screen the antibacterial effect of the combination of pyraclostrobin and quinoline copper in the active ingredients and their preferred combination ratio, this test example used a comparison between the combined preparation and the single-substance active ingredient, as well as a comparison between the combinations of various ratios, and tested the virulence experiment against cucumber downy mildew virus strains under laboratory conditions.

[0054] The test pathogen was Pseudocoron cubanum, which was collected and cultivated from the cucumber downy mildew diseased leaves in the fields of Gaoming District, Foshan City, Guangdong Province, and then diluted with sterile water to 1×10 8 cfu / mL of bacterial suspension.

[0055] Test reagents:

[0056] Table 3 Active ingredient ratios of Comparative Examples 1 to 2 and Test Groups B1 to B12

[0057]

[0058]

[0059] The agents of Comparative Example 1, Comparative Example 2, and Test Examples B1 to B12 were prepared as follows:

[0060] (1) The wetting and dispersing agent is prepared in the amount of 3wt% Agrilan-755, 3wt% D-251, and 2wt% 500HQ, and is evenly dispersed with 10wt% softened water to obtain a wetting and dispersing agent mixed solution; 1 / 3 of the wetting and dispersing agent mixed solution is diluted with 50% softened water and sheared and dispersed to obtain a mixed solution I;

[0061] (2) Weighing the pyraclostrobin technical and quinoline copper technical according to the ratio in Table 3, and air-grinding the two technicals, and then adding them to the mixed solution II, and high-speed shearing at 15000 rpm for not less than 10 minutes to obtain a mixed solution III;

[0062] (3) Add the remaining wetting and dispersing agent mixture into the mixture III in two portions, and keep the high-speed shear at 15,000 rpm. After the wetting and dispersing agent mixture is completely added, add softened water to make up 100% of the preparation, and continue the high-speed shear for not less than 30 minutes to obtain the suspension.

[0063] Antibacterial experiment: The antibacterial effects of comparative example 1, comparative example 2, and test group B1 to test group B12 were detected by the Oxford cup method. Determination of the inhibition zone: (1) The diameter of the inhibition zone is greater than 20 mm, which is extremely sensitive (++++); (2) The diameter of the inhibition zone is between 20 and 15 mm, which is highly sensitive (+++); (3) The diameter of the inhibition zone is between 15 and 10 mm, which is highly sensitive (++); (4) The diameter of the inhibition zone is less than 10 mm, which is low sensitivity (+); (5) No inhibition zone is insensitive (-). The antibacterial effects of the active ingredients of each agent are shown in Table 4.

[0064] Table 4 Antibacterial test results

[0065]

[0066]

[0067] From Table 4 we can see that:

[0068] (1) In general, the antibacterial effect of the combination of pyraclostrobin and quinoline copper is better than that of the single preparations of the two.

[0069] (2) The antibacterial effect of test group B1 is poor because the total amount of active ingredients in its compound is low. The data of other test groups show that when the total amount of active ingredients in the compound reaches 30wt% or above, the antibacterial effect is better.

[0070] (3) When the compounding ratio of pyraclostrobin and quinoline copper is between 2:1 and 1:2, the antibacterial effect gradually increases with the increase of the total amount of active ingredients; but within this range, when the total amount of active ingredients increases to a certain amount, the gain of the antibacterial effect is not obvious. Therefore, considering the cost and antibacterial effect, it is believed that when the compounding ratio of pyraclostrobin and quinoline copper is 1:1 and the total amount of the two is 40wt% to 50wt%, it is the most preferred compounding method of the agent. Furthermore, when the total amount of the two is 50wt% and the compounding ratio is 1:1, the antibacterial effect is the best.

[0071] Embodiment 1~embodiment 28:

[0072] A number of embodiments are given below to further illustrate specific implementations of the present invention, but they are not intended to narrow or limit the protection scope of the present invention.

[0073] The following examples were prepared using the following steps:

[0074] (1) Weighing a wetting and dispersing agent in proportion, dispersing it in 10 wt% to 15 wt% softened water at 8000 rpm to 10000 rpm for 5 min to 10 min until it is uniform, to obtain a wetting and dispersing agent mixed solution; diluting 1 / 3 of the wetting and dispersing agent mixed solution with 40 wt% to 50 wt% softened water and continuing to shear and disperse it uniformly, to obtain a mixed solution I;

[0075] (2) Weighing antifreeze agent, preservative and defoaming agent in proportion; adding the above additives to mixed solution I, dispersing at 8000 rpm to 10000 rpm for 5 min to 20 min until uniform, to obtain mixed solution II;

[0076] (3) weighing the pyraclostrobin technical drug and the quinoline copper technical drug in proportion, and air-grinding the two technical drugs, and then adding them to the mixed solution II, and high-speed shearing at 15000 rpm for about 20 minutes to obtain a mixed solution III;

[0077] (4) weighing the thickener according to the proportion, dispersing it evenly with 5 wt% to 10 wt% of softened water, and high-speed shearing at 10,000 rpm to obtain a thickener mixed solution;

[0078] (5) Place the mixed solution III in a sand mill and grind it to D using zirconium beads of 0.4 mm to 0.7 mm. 98 ≤5.0μm, add the thickener mixture in step 1, grind and mix for 10 to 30 minutes; then add the remaining wetting and dispersing agent mixture into the sand mill in half and twice, add softened water to 100wt%, and grind to D with 0.1mm to 0.2mm zirconium beads. 98 ≤3.0μm;

[0079] (6) Finally, the pH value of the suspension is adjusted to between 5.0 and 6.0 using a pH adjuster. Since some formulations do not require a pH adjuster or the amount of the pH adjuster used is very small, its proportion in the examples can be ignored.

[0080] The formula of each embodiment is as follows:

[0081] Embodiment 1-2:

[0082]

[0083] Embodiment 3-4:

[0084]

[0085] Embodiment 5-6:

[0086]

[0087]

[0088] Embodiment 7-8:

[0089] Embodiment 9-10:

[0090]

[0091] Embodiment 11-12:

[0092]

[0093]

[0094] Embodiment 13-14:

[0095]

[0096] Embodiment 15-16:

[0097]

[0098]

[0099] Embodiment 17-18:

[0100]

[0101] Embodiment 19-20:

[0102]

[0103] Embodiment 21-22:

[0104]

[0105]

[0106] Embodiment 23-24:

[0107]

[0108] Embodiment 25-26:

[0109]

[0110]

[0111] Embodiment 27-28:

[0112]

[0113] Test Example 3:

[0114] This test example is to test the physical properties and stability of the suspension prepared in Example 1 to Example 28. Hot storage: 54℃, 14d. Cold storage: 0℃, 7d. Freeze-thaw: 4℃, 18h~0℃, 6h, 4 cycles. Fluidity judgment standard: "+" qualified; "-" poor fluidity, sedimentation rate does not exceed 30%; "--" poor fluidity, sedimentation rate does not exceed 50%; "×" serious bottoming. The results are shown in Table 5-1 to Table 5-5.

[0115] Table 5-1 Properties of Examples 1 to 6

[0116]

[0117] Table 5-2 Properties of Examples 7 to 12

[0118]

[0119] Table 5-3 Properties of Examples 13 to 18

[0120]

[0121] Table 5-4 Properties of Examples 19 to 24

[0122]

[0123]

[0124] Table 5-5 Properties of Examples 25 to 28

[0125] From Table 5-1 to Table 5-5, we can see that:

[0126] (1) After hot storage, cold storage and freeze-thaw, the fluidity of most of the suspensions in Examples 1 to 28 was acceptable, and a small number of them showed sedimentation, but the overall sedimentation rate did not exceed 50%, and did not affect the use after being shaken well.

[0127] (2) After heat storage, the particle size of most suspension formulations reaches D 90 ≤5.0μm, still meets the particle size requirements of general suspension agents and does not affect its use.

[0128] (3) Among them, the performance of Examples 1 to 4, Examples 11 to 14, and Examples 25 to 28 were relatively good after hot storage, cold storage, and freeze-thaw, and the particle size and fluidity changed little, proving that the stability of the formulations of these examples is more advantageous.

[0129] (4) Analysis of the formula with more stability advantages: a) Adding magnesium aluminum silicate to the thickener will increase the overall stability of the suspension; b) The wetting and dispersing agent uses a composite composition of block polyether polymer and comb polymer, which has better dispersibility of the suspension and can maintain a particle size of D 90 ≤3.0μm; c) The antifreeze agent is a composite composition containing urea, and has better stability after freezing and thawing.

[0130]

Claims

1. A pesticide suspension concentrate of pyraclostrobin and quinoline copper, characterized in that: The active ingredients of the suspension agent include pyraclostrobin and quinoline copper; the proportion of the active ingredients in the suspension agent is 7.5wt% to 65wt%; wherein the content of pyraclostrobin in the suspension agent is 5wt% to 30wt%, and the content of quinoline copper in the suspension agent is 2.5wt% to 35wt%; the balance is auxiliary agents and water.

2. The pesticide suspension concentrate of pyraclostrobin and quinoline copper compound according to claim 1, characterized in that: The mass ratio of the pyraclostrobin to the quinoline copper is 2:1 to 1:

2.

3. The pesticide suspension concentrate of pyraclostrobin and quinoline copper compound according to claim 1, characterized in that: The mass ratio of the pyraclostrobin to the quinoline copper is 1:

1.

4. The pesticide suspension concentrate of pyraclostrobin and quinoline copper compound according to claim 1, characterized in that: The particle size (D 90 )≤3.0μm.

5. The pesticide suspension concentrate of pyraclostrobin and quinoline copper compound according to claim 1, characterized in that: The pH value of the suspending agent is 5.0-8.

0.

6. The pesticide suspension concentrate of pyraclostrobin and quinoline copper compound according to claim 1, characterized in that: The auxiliary agent includes a wetting and dispersing agent, and the wetting and dispersing agent is a non-ionic hydrophilic high molecular polymer dispersant and / or an anionic wetting and dispersing agent.

7. The pesticide suspension concentrate of pyraclostrobin and quinoline copper compound according to claim 1, characterized in that: The auxiliary agent includes a defoamer, and the defoamer is at least one of an organosilicon defoamer, a block polyether defoamer, a polyether defoamer, and a nonionic defoamer.

8. The pesticide suspension concentrate of pyraclostrobin and quinoline copper compound according to claim 1, characterized in that: The auxiliary agent includes a wetting dispersant, a thickener, a preservative, an antifreeze agent, and a defoaming agent; the wetting dispersant is a combination of a nonionic hydrophilic high molecular polymer dispersant and an anionic wetting dispersant.

9. Use of the pesticide suspension prepared from pyraclostrobin and quinoline copper according to any one of claims 1 to 8 in controlling cucumber downy mildew.

10. The use according to claim 9, characterized in that: The dosage of the suspension is 40-75 ml / mu.

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