The invention discloses a pests and disease prevention purposed planting method of soft-seed pomegranates. The pests and disease prevention purposed planting method mainly includes four prevention stages of preplanting, sapling, growing period and fruit period, for preplanting, performing deep plowing the land before planting, spraying a biogenic-source disinfectant, and disinfecting by a soil fumigation mode; for the sapling, growing period and fruit period, performing targeted prevention on different pathogenesis. With the method, to-be-cultivated soil can be kept clean, survival rate of the pomegranates is increased, pest and disease damage of later period is prevented, root, stem and leaf health is kept, photosynthesis of the pomegranates is improved, storage of nutrients is guaranteed, and growth quality of the pomegranates is improved; meanwhile, the disinfectant is the biogenic-source disinfectant, continuous pest killing effect is achieved, antibody cannot be produced to larva, and soil hardening, underground water pollution and harm to human beings cannot occur.