Slow-release parasite expelling tablet and preparation method thereof

Abstract

The invention discloses a slow-release parasite expelling tablet, and relates to the technical field of public place hygiene, the parasite expelling tablet comprises the following components: 40-60 parts of dichlorvos crude oil, 10-20 parts of diisooctyl adipate, 20-30 parts of polyvinyl chloride and 4-9 parts of zinc stearate, the dichlorvos crude oil accounts for 40-60 parts, the diisooctyl adipate accounts for 10-20 parts, the polyvinyl chloride accounts for 20-30 parts, and the zinc stearate accounts for 4-9 parts. The plastic product is prepared from dichlorvos crude oil, polyvinyl chloride and other raw materials, and is a new dosage form for controlling release of dichlorvos volatile gas and keeping long-term efficacy. The dosage form is low in dichlorvos content, but can safely and effectively control slow release, so that the drug effect period is long, the release amount is small, and the residual amount is low. The dichlorvos has the characteristics of easiness in decomposition and the like, so that the pollution to the use environment is reduced.

Description

Technical Field

[0001] The invention relates to the technical field of public place hygiene, in particular to a slow-release anthelmintic tablet. Background Art

[0002] So far, many countries have conducted many experiments on the molding process and formula of slow-release insecticide compositions containing volatile insecticides based on polyvinyl chloride. The main purpose is to change the substrate, reduce the molding temperature, and improve the filler. Most of them use polyvinyl chloride as the substrate containing DDVP volatile insecticide (DDVP). For example, US Patent US3769416 uses polyvinyl chloride as the substrate, which has poor plasticity and needs to add dibutyl phthalate (DOP) plasticizer. Since the mixing and stirring temperature must be 90-100℃, the extrusion molding temperature must be above 130℃. Organic metal salt heat stabilizer must be added. Due to high-temperature molding, the evaporation and decomposition loss of DDVP are accelerated. DDVP and DOP in polyvinyl chloride migrate to the surface of the slow-release insecticide composition together. Long-term storage is unstable, DDVP is effectively consumed early, and the original insect repellent effect is reduced. The manufacturing method of insecticide plastic sheet in the US Chemical Abstracts CA83-73515 is to add polyvinyl alcohol acetal with free hydroxyl groups to form a cross-linked structure with polyvinyl chloride resin. Therefore, the migration of DDVP is not significantly improved, and the evaporation and decomposition of DDVP during high-temperature molding is not alleviated. On the contrary, the cost is increased by adding expensive butyral. The price of butyral is 10 times that of polyvinyl chloride.

[0003] Japanese Patent Publication No. 49-34461 proposed using chlorinated polyethylene as a substrate and filling it with calcium carbonate. This is a further improvement on the manufacture of slow-release insecticidal compositions based on polyvinyl chloride. The molding temperature is reduced and the operating environment is improved. However, chlorinated polyethylene as a substrate is more expensive, 3 times that of polyvinyl chloride, and the phenomenon of DDVP migration to the surface of the insecticidal tablets still occurs when the tablet surface becomes sticky. The product variety is single and the scope of application is relatively small. Summary of the invention

[0004] In view of the shortcomings of the prior art, the present invention provides a slow-release insect repellent tablet that solves the problems raised in the background technology.

[0005] To achieve the above objectives, the present invention is implemented by the following technical scheme: a sustained-release anthelmintic tablet, the anthelmintic tablet raw materials include dichlorvos crude oil, diethylhexyl adipate, polyvinyl chloride and zinc stearate, and its components are as follows:

[0006] 40-60 parts of dichlorvos crude oil, 10-20 parts of diethylhexyl adipate, 20-30 parts of polyvinyl chloride, 4-9 parts of zinc stearate.

[0007] As a preferred technical solution of the present invention, its components are as follows:

[0008] 45 parts of dichlorvos crude oil, 10 parts of diethylhexyl adipate, 25 parts of polyvinyl chloride and 6 parts of zinc stearate.

[0009] As a preferred technical solution of the present invention, its components are as follows:

[0010] 55 parts of dichlorvos crude oil, 10 parts of diethylhexyl adipate, 25 parts of polyvinyl chloride and 4 parts of zinc stearate.

[0011] As a preferred technical solution of the present invention, the preparation method of the insect repellent tablet is as follows:

[0012] S1: Mix the crude dichlorvos and polyvinyl chloride in a mixing tank according to the proportion and stir evenly;

[0013] S2: Let stand for 10 minutes, add diisooctyl adipate and zinc stearate into the batching tank, and stir evenly;

[0014] S3: Let it stand for 30 minutes to make it solid, and then use a mold to make it into a square insect repellent tablet.

[0015] As a preferred technical solution of the present invention, in step S2, before adding diethyl hexyl adipate and zinc stearate into the batching tank, it is necessary to use one or more of a weak base such as Na2C03, ammonia water, nitrogen, NaHCO3, triethylamine, pyridine, etc. in combination with a strong base (such as NaOH, KOH) as the base used for alkaline hydrolysis of dichlorvos, replacing the single strong base NaOH.

[0016] The present invention provides a sustained-release insect repellent tablet and a preparation method thereof. The tablet has the following beneficial effects:

[0017] This slow-release insect repellent tablet is made of plastic products made of raw materials such as dichlorvos crude oil and polyvinyl chloride. It is a new dosage form that controls the release of dichlorvos volatile gas and maintains long-term efficacy. This dosage form has a low dichlorvos content, but can safely and effectively control the slow release, so it has a long efficacy period, a small release amount, and a low residue. Dichlorvos itself has the characteristics of being easy to decompose, thereby reducing pollution to the use environment. DETAILED DESCRIPTION

[0018] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0019] The embodiment of the present invention provides a technical solution: a sustained-release anthelmintic tablet, the raw materials of which include dichlorvos crude oil, diethylhexyl adipate, polyvinyl chloride and zinc stearate, and the components thereof are as follows:

[0020] 40-60 parts of dichlorvos crude oil, 10-20 parts of diethylhexyl adipate, 20-30 parts of polyvinyl chloride, 4-9 parts of zinc stearate.

[0021] As a preferred technical solution of the present invention, its components are as follows:

[0022] 45 parts of dichlorvos crude oil, 10 parts of diethylhexyl adipate, 25 parts of polyvinyl chloride and 6 parts of zinc stearate.

[0023] As a preferred technical solution of the present invention, its components are as follows:

[0024] 55 parts of dichlorvos crude oil, 10 parts of diethylhexyl adipate, 25 parts of polyvinyl chloride and 4 parts of zinc stearate.

[0025] As a preferred technical solution of the present invention, the preparation method of the insect repellent tablet is as follows:

[0026] S1: Mix the crude dichlorvos and polyvinyl chloride in a mixing tank according to the proportion and stir evenly;

[0027] S2: Let stand for 10 minutes, add diisooctyl adipate and zinc stearate into the batching tank, and stir evenly;

[0028] S3: Let it stand for 30 minutes to make it solid, and then use a mold to make it into a square insect repellent tablet.

[0029] As a preferred technical solution of the present invention, in step S2, before adding diethyl hexyl adipate and zinc stearate into the batching tank, it is necessary to use one or more of a weak base such as Na2C03, ammonia water, nitrogen, NaHCO3, triethylamine, pyridine, etc. in combination with a strong base (such as NaOH, KOH) as the base used for alkaline hydrolysis of dichlorvos, replacing the single strong base NaOH.

[0030] Main features of the present invention

[0031] In the composition based on PVC as the base material based on the US invention patent (US3769416), zinc stearate and epoxidized soybean oil are added. The addition of this component greatly increases the stability of PVC, so that DDVP can volatilize continuously and stably, and the concentration of DDVP is kept in a stable range within the recommended use space, which is sufficient to kill or drive away the reproduction of invertebrate pests and their eggs. Compared with the US patent product, because it is too dry, the PVC base material is still not dense enough. In an environment with an average room temperature of 20 degrees or above, the DDVP volatilization process is too fast in the early stage, resulting in too high a concentration of DDVP in the air. In a very short time, the concentration drops significantly, resulting in a loss of effect.

[0032] Key benefits:

[0033] It has slow-release properties, which can increase the effective period of pesticides, reduce the amount of pesticides used, improve utilization rate and save costs.

[0034] Improve the stability of pesticides and avoid decomposition, oxidation, loss, etc. of pesticides due to physical, chemical and microbial environmental influences. When this product is stored in a sealed container, the resin can be stored for a long time and the pesticide content will not be significantly reduced.

[0035] Dichlorvos can have a lethal effect on mosquitoes even at extremely low concentrations in the gas phase. This product makes dichlorvos into a resin preparation, which can effectively control the volatilization of dichlorvos and greatly reduce its volatility, thereby avoiding direct contact between humans and animals and causing poisoning incidents, and effectively killing mosquitoes.

[0036] Due to the relatively high volatility of DDT, the volatilization rate of emulsions and other preparations after spraying is uncontrolled and the effective period is very limited. In order to achieve the desired effect, repeated application of the pesticide is necessary, which greatly increases the potential risks of the case. The effective period of this product is up to 60 days, and the concentration of DDT in the air is low when used, which will not be toxic to humans and animals.

[0037] Role of resistance management in existing registered products

[0038] 18.6% Dichlorvos Tablets can play a positive role in the resistance management of existing sanitary insecticide products due to their unique dosage form and application method. The traditional residual spraying method requires high technical skills and often requires more professional operation, and different particle sizes are required for different surfaces. In addition, due to operational reasons, the pesticide dosage may be insufficient, promoting the target pests to develop resistance to pesticides, or excessive dosage may cause safety hazards and environmental pollution. 18.6% Dichlorvos Tablets slowly release Dichlorvos and are easy to operate. They will not cause pests to develop resistance to them due to improper use and operation, and this slow release method can effectively avoid poisoning incidents.

[0039] The product of the present invention is applicable to confined spaces such as garbage rooms, libraries, hotels, storage rooms, pastures such as dairy cow sheds, etc., and has an extremely good insect repellent effect (mainly preventing and controlling objects: cockroaches, mosquitoes, flies, spiders, moths, centipedes, bark beetles, and hairy midges).

[0040] Significance of the invention: can replace higher risk pesticides

[0041] 18.6% dichlorvos tablets are used to control indoor mosquitoes. The method of use is hanging. It is a relatively new way of applying pesticides. It is simple to operate and convenient for residents to use. In China, in addition to being widely used in the prevention and control of agricultural products, dichlorvos is also widely used in the combined management of sanitary products. In the health field, dichlorvos is often developed into emulsifiable concentrates. 18.6% dichlorvos tablets have further expanded the market for dichlorvos preparations and expanded the range of choices for users. At present, there are no dichlorvos tablets registered in China. After efficacy tests, it was found that 18.6% dichlorvos tablets have better indoor prevention effects and longer lasting effects. It can replace the higher-risk pesticide products on the market.

[0042] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It is obvious to those skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention.

[0043] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A sustained-release anthelmintic tablet, characterized in that: The insect repellent tablets include dichlorvos crude oil, diethylhexyl adipate, polyvinyl chloride and zinc stearate, and its components are as follows: 40-60 parts of dichlorvos crude oil, 10-20 parts of diethylhexyl adipate, 20-30 parts of polyvinyl chloride, 4-9 parts of zinc stearate.

2. The sustained-release insect repellent tablet according to claim 1, characterized in that: Its components are as follows: 45 parts of dichlorvos crude oil, 10 parts of diethylhexyl adipate, 25 parts of polyvinyl chloride and 6 parts of zinc stearate.

3. The sustained-release insect repellent tablet according to claim 1, characterized in that: Its components are as follows: 55 parts of dichlorvos crude oil, 10 parts of diethylhexyl adipate, 25 parts of polyvinyl chloride and 4 parts of zinc stearate.

4. The method for preparing a sustained-release anthelmintic tablet according to claim 1, characterized in that: S1: Mix the crude dichlorvos and polyvinyl chloride in a mixing tank according to the proportion and stir evenly; S2: Let stand for 10 minutes, add diisooctyl adipate and zinc stearate into the batching tank, and stir evenly; S3: Let it stand for 30 minutes to make it solid, and then use a mold to make it into a square insect repellent tablet.

5. The method for preparing a sustained-release anthelmintic tablet according to claim 4, characterized in that: In step S2, before adding diethyl hexyl adipate and zinc stearate into the batching tank, it is necessary to use one or more of a weak base such as Na2C03, ammonia water, nitrogen, NaHCO3, triethylamine, pyridine, etc. in combination with a strong base (such as NaOH, KOH) as the base used for alkaline hydrolysis of dichlorvos, replacing the single strong base NaOH.