Soothing and moisturizing bath oil for assisting in improving atopic dermatitis and preparation method thereof

Abstract

The invention relates to the field of medicine and personal care products, and provides soothing and moisturizing bath oil capable of assisting in improving atopic dermatitis, the soothing and moisturizing bath oil is composed of grease, a surfactant, an emulsifier, an active functional component and a solvent, the grease comprises caprylic / capric triglyceride, jojoba oil and tocopheryl acetate; the surfactant is prepared from lauryl alcohol polyether sulfate (TIPA) salt and cocamide (MEA); the emulsifying agent is prepared from lauryl alcohol polyether-4 and cetearyl alcohol; the bath oil can relieve clinical symptoms of atopic dermatitis patients, such as pruritus, skin flushing and dryness, is high in comfort level and good in moisturizing performance, has the effects of increasing the water content of cuticle and promoting barrier repair, avoids further damage of skin barriers caused by excessive cleaning, can be used as a basic product for daily nursing of children with atopic dermatitis, and has a wide application prospect in daily nursing of children with atopic dermatitis. The invention further provides active ingredients of the bath oil and a preparation method of the bath oil.

Description

Technical Field

[0001] The invention belongs to the field of medicine and personal care products, and particularly relates to a soothing and moisturizing bath oil for assisting in improving atopic dermatitis and a preparation method thereof. Background Art

[0002] Atopic dermatitis (AD), also known as atopic eczema, atopic dermatitis, and genetic allergic dermatitis, is a genetic, immune-related chronic, recurrent, pruritic, inflammatory, systemic skin disease. The main clinical manifestations are dry skin, erythema and papules on the flexor side of the body, and in severe cases, erosion and exudation, accompanied by severe itching; and patients often have concurrent airway allergic diseases such as asthma and allergic rhinitis.

[0003] The prevalence of the disease is high among preschool children, who present with abnormally dry skin and repeated inflammation. The pathological mechanism is that, under the genetic background, the synthesis of moisturizing factors is deficient, the skin barrier is damaged, and the skin is abnormally dry. On this basis, external allergens and irritants cause percutaneous sensitization and induce inflammation. Modern medical treatment mainly includes local treatments, such as hormones, immunosuppressants, and biological agents. However, no matter which type of treatment is used, it is inseparable from the moisturizing and washing aspects of basic treatment. The skin of patients with atopic dermatitis with damaged skin barriers requires more professional and effective washing products for daily washing and care and certain auxiliary improvement effects. This is the fundamental reason why the inventor developed a soothing and moisturizing bath oil containing Chinese medicine extracts. Summary of the invention

[0004] The purpose of the present invention is to address the above shortcomings, provide a soothing and moisturizing bath oil and a preparation method thereof for assisting in improving atopic dermatitis, and also provide an effective ingredient that has the effect of moisturizing and soothing inflammation.

[0005] The technical solution of the present invention is implemented as follows: a bath oil active ingredient comprises Rehmannia root extract, Forsythia suspensa essential oil, Peony seed oil, Evening primrose oil, and ceramide NP in a mass ratio of (10-30):(5-10):(10-20):(5-10):(5-10).

[0006] A soothing and moisturizing bath oil for assisting in improving atopic dermatitis comprises: oil, surfactant, emulsifier, active functional ingredients and solvent, wherein the oil comprises caprylic / capric triglyceride, jojoba oil and tocopherol acetate; the surfactant comprises laureth sulfate TIPA salt and cocamide MEA; the emulsifier comprises laureth-4 and cetearyl alcohol; wherein caprylic / capric triglyceride accounts for 5-25% of the bath oil mass, the jojoba oil accounts for 5-25% of the bath oil mass, the tocopherol acetate accounts for 3-7% of the bath oil mass, the laureth sulfate TIPA salt accounts for 10-20% of the bath oil mass, the cocamide MEA accounts for 1-5% of the bath oil mass, the laureth-4 accounts for 10-25% of the bath oil mass, the cetearyl alcohol accounts for 1-5% of the bath oil mass, the active functional ingredients are the above-mentioned active functional ingredients, and the active functional ingredients account for 2.2-6.2% of the bath oil mass; and the rest is solvent.

[0007] Furthermore, the solvent is propylene glycol / panthenol.

[0008] Furthermore, the solvent is glycerin / panthenol.

[0009] The preparation method of the soothing bath oil comprises the following steps: (1) uniformly mixing a solvent, a root extract of Rehmannia glutinosa, laureth-4 and laureth sulfate TIPA salt, and homogenizing the mixture at 30 to 40 rpm, 75 to 80° C. and -0.05 to -0.04 MPa, while maintaining the temperature constant, and homogenizing the mixture until the mixture becomes transparent, thereby obtaining a liquid A.

[0010] (2) Add jojoba oil, caprylic / capric triglyceride, cocamide MEA, and cetearyl alcohol to liquid A, and stir evenly to obtain liquid B.

[0011] (3) Adding forsythia essential oil, peony seed oil, evening primrose oil, ceramide NP, and tocopherol acetate to liquid B, stirring evenly, cooling, discharging, and standing to obtain the soothing and moisturizing bath oil.

[0012] The beneficial effects of the present invention are as follows: the invention provides a soothing and moisturizing bath oil for assisting in improving atopic dermatitis, and also provides effective functional ingredients of the bath oil and a method for preparing the bath oil; the bath oil has stable and lasting foam, high safety, is mild and does not irritate the skin, and can moderately cleanse, moisturize, and have anti-inflammatory and soothing effects; the present invention enables the bath oil to have a refreshing, moisturizing, and non-slippery skin feel by screening the types and contents of each component; the bath oil of the present invention has better moisturizing and skin inflammation inhibition effects through the synergistic effect of forsythia essential oil, rehmannia extract, and peony seed oil. DETAILED DESCRIPTION

[0013] In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0014] Example 1 Preparatory steps First, prepare the active ingredients, and prepare 220 g of Rehmannia root extract, Forsythia suspensa essential oil, Peony seed oil, Evening primrose oil, and Ceramide NP according to a weight ratio of 10:5:10:5:5; Specifically, 62.86g of Rehmannia root extract, 31.43g of Forsythia suspensa essential oil, 62.86g of Peony seed oil, 31.43g of Evening Primrose oil, and 31.43g of Ceramide; Then prepare 500g of caprylic capric triglyceride, 2500g of jojoba oil, 300g of tocopherol acetate, 1000g of laureth sulfate TIPA salt, 500g of cocamide MEA, 1000g of laureth-4, 500g of cetearyl alcohol, 1480g of propylene glycol, and 2000g of panthenol. Propylene glycol and panthenol are used as solvents, the same below.

[0015] Example 2 Preparatory steps First, prepare the active ingredients, and prepare 220 g of Rehmannia root extract, Forsythia suspensa essential oil, Peony seed oil, Evening primrose oil, and Ceramide NP according to a weight ratio of 10:5:10:5:5; Specifically, 62.86g of Rehmannia root extract, 31.43g of Forsythia suspensa essential oil, 62.86g of Peony seed oil, 31.43g of Evening Primrose oil, and 31.43g of Ceramide; Then prepare 2500g of caprylic capric triglyceride, 500g of jojoba oil, 700g of tocopherol acetate, 2000g of laureth sulfate TIPA salt, 100g of cocamide MEA, 2500g of laureth-4, 100g of cetearyl alcohol, 380g of propylene glycol, and 1000g of panthenol.

[0016] Example 3 Preparatory steps First, prepare the active ingredients, and prepare 220 g of Rehmannia root extract, Forsythia suspensa essential oil, Peony seed oil, Evening primrose oil, and Ceramide NP according to a weight ratio of 30:10:20:10:10; Specifically, 82.5g of Rehmannia root extract, 27.5g of Forsythia suspensa essential oil, 55g of Peony seed oil, 27.5g of Evening Primrose oil, and 27.5g of Ceramide; Then prepare 500g of caprylic capric triglyceride, 2500g of jojoba oil, 300g of tocopherol acetate, 1000g of laureth sulfate TIPA salt, 500g of cocamide MEA, 1000g of laureth-4, 500g of cetearyl alcohol, 1480g of propylene glycol, and 2000g of panthenol.

[0017] Example 4 Preparatory steps First, prepare the active ingredients, and prepare 220 g of Rehmannia root extract, Forsythia suspensa essential oil, Peony seed oil, Evening primrose oil, and Ceramide NP according to a weight ratio of 30:10:20:10:10; Specifically, 82.5g of Rehmannia root extract, 27.5g of Forsythia suspensa essential oil, 55g of Peony seed oil, 27.5g of Evening Primrose oil, and 27.5g of Ceramide; Then prepare 2500g of caprylic capric triglyceride, 500g of jojoba oil, 700g of tocopherol acetate, 2000g of laureth sulfate TIPA salt, 100g of cocamide MEA, 2500g of laureth-4, 100g of cetearyl alcohol, 380g of propylene glycol, and 1000g of panthenol.

[0018] Example 5 Preparatory steps First, prepare the active ingredients, and prepare 620 g of Rehmannia root extract, Forsythia suspensa essential oil, Peony seed oil, Evening primrose oil, and Ceramide NP according to a weight ratio of 10:5:10:5:5; Specifically, 177g of Rehmannia root extract, 88.5g of Forsythia suspensa essential oil, 177g of Peony seed oil, 88.5g of Evening Primrose oil, and 88.5g of Ceramide; Then prepare 500g of caprylic capric triglyceride, 2500g of jojoba oil, 300g of tocopherol acetate, 1000g of laureth sulfate TIPA salt, 500g of cocamide MEA, 1000g of laureth-4, 500g of cetearyl alcohol, 1480g of propylene glycol, and 1600g of panthenol.

[0019] Example 6 Preparatory steps First, prepare the active ingredients, and prepare 620 g of Rehmannia root extract, Forsythia suspensa essential oil, Peony seed oil, Evening primrose oil, and Ceramide NP according to a weight ratio of 10:5:10:5:5; Specifically, 177g of Rehmannia root extract, 88.5g of Forsythia suspensa essential oil, 177g of Peony seed oil, 88.5g of Evening Primrose oil, and 88.5g of Ceramide; Then prepare 2500g of caprylic capric triglyceride, 500g of jojoba oil, 700g of tocopherol acetate, 2000g of laureth sulfate TIPA salt, 100g of cocamide MEA, 2500g of laureth-4, 100g of cetearyl alcohol, 380g of propylene glycol, and 600g of panthenol.

[0020] Example 7 Preparatory steps First, prepare the active ingredients, and prepare 620 g of Rehmannia root extract, Forsythia suspensa essential oil, Peony seed oil, Evening primrose oil, and Ceramide NP according to a weight ratio of 30:10:20:10:10; Specifically, 232.5g of Rehmannia root extract, 77.5g of Forsythia suspensa essential oil, 155g of Peony seed oil, 77.5g of Evening Primrose oil, and 77.5g of Ceramide; Then prepare 500g of caprylic capric triglyceride, 2500g of jojoba oil, 300g of tocopherol acetate, 1000g of laureth sulfate TIPA salt, 500g of cocamide MEA, 1000g of laureth-4, 500g of cetearyl alcohol, 1480g of propylene glycol, and 1600g of panthenol.

[0021] Example 8 Preparatory steps First, prepare the active ingredients, and prepare 620 g of Rehmannia root extract, Forsythia suspensa essential oil, Peony seed oil, Evening primrose oil, and Ceramide NP according to a weight ratio of 30:10:20:10:10; Specifically, 232.5g of Rehmannia root extract, 77.5g of Forsythia suspensa essential oil, 155g of Peony seed oil, 77.5g of Evening Primrose oil, and 77.5g of Ceramide; Then prepare 2500g of caprylic capric triglyceride, 500g of jojoba oil, 700g of tocopherol acetate, 2000g of laureth sulfate TIPA salt, 100g of cocamide MEA, 2500g of laureth-4, 100g of cetearyl alcohol, 380g of propylene glycol, and 600g of panthenol.

[0022] Example 9 Preparatory steps First, prepare the active ingredients, and prepare 420 g of Rehmannia root extract, Forsythia suspensa essential oil, Peony seed oil, Evening primrose oil, and Ceramide NP according to a weight ratio of 20:7:15:7:7; Specifically, 150g of Rehmannia root extract, 52.5g of Forsythia suspensa essential oil, 112.5g of Peony seed oil, 52.5g of Evening Primrose oil, and 52.5g of Ceramide; Then prepare 1500g of caprylic capric triglyceride, 1500g of jojoba oil, 500g of tocopherol acetate, 1500g of laureth sulfate TIPA salt, 300g of cocamide MEA, 1500g of laureth-4, 300g of cetearyl alcohol, 1480g of propylene glycol, and 1000g of panthenol.

[0023] Comparative Example 1 The difference from Example 1 is that 1480 g of propylene glycol and 2000 g of panthenol in Example 1 are replaced with 1480 g of glycerol and 2000 g of panthenol, and glycerol and panthenol are used as solvents.

[0024] Comparative Example 2 The difference from Example 9 is that 1480 g of propylene glycol and 1000 g of panthenol in Example 9 are replaced with 1480 g of glycerol and 1000 g of panthenol, and glycerol and panthenol are used as solvents.

[0025] Comparative Example 3 A shower gel from Safeguard.

[0026] Comparative Example 4 Lux powdery peach scent delicate skin fragrance shower gel.

[0027] The above Examples 1-9 and Comparative Examples 1-2 were produced according to the following steps: (1) The solvent, the extract of Rehmannia glutinosa root, laureth-4, and laureth sulfate TIPA salt are mixed uniformly, and homogenized at 30-40 rpm, 75-80° C., and -0.05--0.04 MPa. The temperature is kept constant, and the mixture is homogenized until the material becomes transparent to obtain liquid A.

[0028] (2) Add jojoba oil, caprylic / capric triglyceride, cocamide MEA, and cetearyl alcohol to liquid A, and stir to obtain liquid B.

[0029] (3) Adding forsythia essential oil, peony seed oil, evening primrose oil, ceramide NP, and tocopherol acetate to liquid B, stirring evenly, cooling, discharging, and standing to obtain the soothing and moisturizing bath oil.

[0030] The soothing and moisturizing bath oils of the above embodiments and comparative examples were prepared and then tested. The test results are as follows: 39 infants and children with atopic dermatitis (0-7 years old) were divided into 13 groups, with 3 cases in each group, and the bath oils and shower gels of Examples 1-9 and Comparative Examples 1-4 were distributed respectively.

[0031] 2. Diagnostic criteria The diagnostic criteria are in accordance with the Williams criteria, as shown in Table 3. Inclusion criteria: 1) meeting the Williams diagnostic criteria; 2) signing the informed consent.

[0032] Exclusion criteria: 1) Patients with acute damage such as blisters, erosions, and exudates in the skin lesions; 2) Patients with abnormal examinations of the blood system, liver, kidney, heart and other systems; patients with mental illness, malignant tumors; or patients with other skin diseases or infectious diseases; 3) Patients who have used glucocorticoids, immunosuppressants, immunomodulators, oral antibiotics, and glucocorticoids, calcineurin inhibitors, and topical antibiotics in the past 2 weeks. 4) Patients who are not suitable for treatment with this clinical research method, such as those who are known to be intolerant to the test drug. 5) Patients with poor compliance, who have not been injected according to regulations or who have taken or applied other drugs that may affect the efficacy without authorization during the trial. 7) Those who have participated in other drug clinical trials within three months. 8) Other situations that the researchers believe are not suitable for inclusion.

[0033] Bathing method: 13 groups of patients were given the bath soothing moisturizing oil produced in Examples 1-9, the bath soothing moisturizing oil produced in Comparative Examples 1-2, and other brands of bath oil in Comparative Examples 3-4, and were asked to bathe and wash by themselves, record the number of bathing times, and observe for 2 weeks. The IGA and p-nrs of the 13 cases were also recorded, and the researcher's overall evaluation (IGA) was recorded, including 0 points for no rash, 1 point for almost no rash, 2 points for mild rash, 3 points for moderate rash, and 4 points for severe rash. The pruritus numerical rating scale (P-NRS) has a score of 0-10 representing the degree of itching. The recorded results are as follows: It can be concluded from the above table that the soothing and moisturizing shower oil provided by the present invention has a good moisturizing effect, and its moisturizing property is stronger than that of general shower gels on the market. This product can relieve the clinical symptoms of patients with atopic dermatitis, such as itching, skin flushing, and dryness, has a high degree of comfort, and avoids further damage to the skin barrier caused by excessive cleaning. It can be used as a basic product for daily care of children with atopic dermatitis to assist in improving the symptoms of atopic dermatitis.

[0034] The soothing and moisturizing bath oil uses a sophisticated formula of Forsythia suspensa essential oil, Rehmannia root extract, and Peony seed oil. The three have a good synergistic effect in moisturizing and inhibiting skin inflammation, and play a major role in relieving skin redness and itching. Ceramide NP in the bath oil acts as a bionic vernix, mimicking the lipids in vernix to form a bionic vernix composition that has the effects of moisturizing, increasing the water content of the stratum corneum, and promoting barrier repair.

[0035] Therefore, from the perspectives of traditional Chinese medicine pharmacology and modern technology, it is explained that bath oil can improve the symptoms of atopic dermatitis, reduce the use of hormonal drugs, and be safer and gentler.

Claims

1. A bath oil active ingredient, which is composed of Rehmannia root extract, Forsythia suspensa essential oil, Peony seed oil, Evening primrose oil, and ceramide NP in a mass ratio of (10-30):(5-10):(10-20):(5-10):(5-10).

2. The bath oil active ingredient according to claim 1, characterized in that: The mass ratio of Rehmannia root extract, Forsythia suspensa essential oil, Peony seed oil, Evening primrose oil, and ceramide NP is 20:7:15:7:

7.

3. A soothing and moisturizing bath oil for assisting in improving atopic dermatitis, which is composed of oil, surfactant, emulsifier, active functional ingredients and solvent, wherein the oil includes caprylic / capric triglyceride, jojoba oil and tocopherol acetate; the surfactant includes laureth sulfate TIPA salt and cocamide MEA; the emulsifier includes laureth-4 and cetearyl alcohol; wherein, The caprylic / capric triglyceride accounts for 5-25% of the mass of the bath oil, the jojoba oil accounts for 5-25% of the mass of the bath oil, the tocopherol acetate accounts for 3-7% of the mass of the bath oil, the laureth sulfate TIPA salt accounts for 10-20% of the mass of the bath oil, the cocamide MEA accounts for 1-5% of the mass of the bath oil, the laureth-4 accounts for 10-25% of the mass of the bath oil, the cetearyl alcohol accounts for 1-5% of the mass of the bath oil, the active ingredient is the active ingredient of claim 1 or 2, and the active ingredient accounts for 2.2-6.2% of the mass of the bath oil; the rest is solvent.

4. The soothing and moisturizing bath oil according to claim 3, characterized in that The solvents are propylene glycol and panthenol.

5. The soothing and moisturizing bath oil according to claim 3, characterized in that The solvents described are glycol and panthenol.

6. A method for preparing a soothing and moisturizing bath oil, comprising the following steps: (1) The solvent of claim 3, 4 or 5, the extract of Rehmannia glutinosa root, laureth-4 and laureth sulfate TIPA salt are mixed uniformly, and homogenized at 30-40 rpm, 75-80° C., and -0.05--0.04 MPa, while maintaining the temperature unchanged, and homogenizing until the material becomes transparent to obtain liquid A; (2) adding jojoba oil, caprylic / capric triglyceride, cocamide MEA, and cetearyl alcohol according to claim 3, 4 or 5 to liquid A, and stirring uniformly to obtain liquid B; (3) Add the forsythia essential oil, peony seed oil, evening primrose oil, ceramide NP, and tocopherol acetate of claim 3, 4 or 5 to liquid B, stir evenly, cool down, discharge, and let stand to obtain the soothing and moisturizing bath oil.

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