Rheum officinale sodium copper chlorophyllin capsule, preparation method thereof and rheum officinale sodium copper chlorophyllin product

Abstract

The invention provides a rheum officinale sodium copper chlorophyllin capsule which comprises the following raw materials in parts by weight: 100 parts of rheum officinale; 50 parts of sodium copper chlorophyllin; 90 to 100 parts of an excipient; 20-35 parts of a disintegrating agent; and 1-3 parts of a lubricant. The radix et rhizoma rhei sodium copper chlorophyllin capsule meeting the quality requirement is prepared through a reasonable prescription combination form. The problem that the content of sodium copper chlorophyllin is greatly reduced in the preparation process can be solved, and the quality and stability of the product are improved. The prepared rheum officinale sodium copper chlorophyllin capsule has better stability in the pharmaceutical production, transportation and use processes, and has no obvious change along with the placement process, the safety of administration of the product is greatly improved, the packaging combination avoids the influence of the air permeability / water permeability of the packaging material on the pharmaceutical quality, and the pharmaceutical quality is improved. And the clinical use of a patient is safer and more stable.

Description

Technical Field

[0001] The invention relates to the technical field of medicines, and in particular to a sodium copper rhubarb chlorophyllin capsule and a preparation method thereof and a sodium copper rhubarb chlorophyllin product. Background Art

[0002] Sodium Copper Rhubarb Chlorophyllin Capsules are used as an auxiliary medicine for the treatment of constipation and acute and chronic hepatitis, and can also be used for leukopenia.

[0003] Rhubarb is a traditional Chinese medicine. The main component of rhubarb is anthraquinone, which is the main component for treating constipation. Rhubarb has a protective effect on stomach, duodenum and liver damage, and can promote the secretion of bile and pancreas. Rhubarb also has the effect of protecting the liver.

[0004] Sodium copper chlorophyllin is a chlorophyll derivative obtained by saponification and copper substitution of chlorophyll extracted from silkworm excrement. It is more stable than chlorophyll. Sodium copper chlorophyllin is easily absorbed by the human body and has the effect of promoting metabolism of body cells. It can also promote the healing of gastrointestinal ulcers and the recovery of liver function. Sodium copper chlorophyllin is a hematopoietic cell complex. Some studies believe that the mechanism by which chlorophyllin increases white blood cells is mainly through increasing the excitability of sympathetic nerves and releasing neutrophils from the bone marrow with the participation of the liver and adrenal glands. There are also reports that the hematopoietic effect of chlorophyllin is because the basic structure of chlorophyllin is a porphyrin ring composed of four pyrrole rings, which is very similar to the structure of hemoglobin, so it can promote hematopoiesis. In clinical practice, sodium copper chlorophyllin is used for the adjuvant treatment of acute and chronic hepatitis and leukopenia.

[0005] The oral compound preparation of rhubarb and sodium copper chlorophyllin has a good effect in treating constipation and protecting the liver. However, there are also the following technical difficulties in the process and storage of its oral preparation. First, because sodium copper chlorophyllin is unstable when it comes into contact with water at high temperatures, copper ions will hydrolyze into copper hydroxide precipitation, causing the structure of sodium copper chlorophyllin to change. Therefore, the granulation of oral compound preparations of rhubarb and sodium copper chlorophyllin by dry / wet granulation is extremely challenging; secondly, rhubarb has poor water solubility and fluidity, which to a certain extent limits the preparation of intermediate particles of oral compound preparations of rhubarb and sodium copper chlorophyllin by powder direct compression technology; finally, because sodium copper chlorophyllin has strong hygroscopicity, long-term storage will lead to a significant decrease in content and dissolution rate.

[0006] Therefore, developing a suitable combination of prescription, process and packaging to ensure the content uniformity of the product intermediate particles, without changing the properties of sodium copper chlorophyll in the intermediate particles, and improving the stability of the preparation product is of great significance to improving the quality and clinical efficacy of oral compound preparations of rhubarb chlorophyll. Summary of the invention

[0007] In view of this, the technical problem to be solved by the present invention is to provide a sodium copper rhubarb chlorophyll capsule; the prescription of the present invention can solve the problem of a significant reduction in the sodium copper chlorophyll content during the preparation process, thereby improving the quality and stability of the product.

[0008] The present invention provides a sodium copper rhubarb chlorophyll capsule, comprising the following raw materials in parts by weight:

[0009] 100 parts of rhubarb; 50 parts of sodium copper chlorophyllin; 90-100 parts of excipients; 20-35 parts of disintegrants; and 1-3 parts of lubricants.

[0010] In some embodiments of the present invention, the sodium copper rhubarb chlorophyllin capsules include the following raw materials in parts by weight:

[0011] 100 parts of rhubarb; 50 parts of sodium copper chlorophyllin; 92-98 parts of excipients; 25-32 parts of disintegrants; and 2 parts of lubricants.

[0012] In some embodiments of the present invention, the sodium copper rhubarb chlorophyllin capsules include the following raw materials in parts by weight:

[0013] 100 parts of rhubarb; 50 parts of sodium copper chlorophyllin; 95 parts of excipients; 30 parts of disintegrants; and 2 parts of lubricants.

[0014] According to the present invention, the excipient includes lactose, sucrose or maltose;

[0015] The disintegrant is microcrystalline cellulose, amylose or amylopectin;

[0016] The lubricant is magnesium stearate, stearic acid or silicon dioxide.

[0017] The present invention does not limit the sources of the above components, and those skilled in the art may suffice.

[0018] The invention provides a method for preparing sodium copper rhubarb chlorophyll capsules, comprising:

[0019] A) adding rhubarb, disintegrant and excipient into a fluidized bed; adding sodium copper chlorophyllin solution by spraying; and then performing boiling granulation;

[0020] B) Lubricant is added to the granulated material, mixed, and filled into capsules.

[0021] According to the preparation method of sodium copper rhubarb chlorophyllin capsule provided by the present invention, rhubarb, disintegrant and excipient are firstly added into a fluidized bed.

[0022] The invention dissolves sodium copper rhubarb chlorophyllin in 10-20% ethanol solution to prepare a 10% sodium copper rhubarb chlorophyllin solution.

[0023] The sodium copper chlorophyllin solution is added in a spraying manner; and then boiling granulation is performed; the boiling granulation of the present invention is medium-low temperature boiling granulation.

[0024] The temperature of the boiling granulation of the present invention is 45-65°C, preferably 55-60°C, specifically 45°C, 47°C, 49°C, 50°C, 52°C, 54°C, 56°C, 58°C, 60°C, 62°C, 63°C, 65°C; or a range between any two of the above.

[0025] The boiling granulation time of the present invention is ≤60min, preferably 30min to 45min.

[0026] When the moisture content of the material in the fluidized bed is ≤3%, granulation is stopped.

[0027] According to the present invention, the prepared rhubarb chlorophyll capsule intermediate product particles have the characteristics of a content of not less than 97% and a content uniformity RSD≤2%.

[0028] The sodium copper rhubarb chlorophyllin capsules prepared by the above technology have good content uniformity (RSD≤2%) and stable content during the stability test (accelerated content decrease≤5%).

[0029] The above technical solution of the present invention improves the situation that the content of intermediate particles decreases during the granulation process.

[0030] The invention provides a sodium copper rhubarb chlorophyll capsule, which is prepared by the preparation method described in any one of the above technical solutions.

[0031] The present invention has clearly described the preparation method above, which will not be repeated here.

[0032] The chemical stability of sodium copper rhubarb chlorophyllin capsules is greatly improved, and the degradation of sodium copper chlorophyllin in sodium copper rhubarb chlorophyllin capsules is significantly reduced under high temperature conditions.

[0033] The invention provides a sodium copper rhubarb chlorophyllin product, comprising the sodium copper rhubarb chlorophyllin capsule and packaging described in the above technical solution.

[0034] The products of the present invention include health products or medicines.

[0035] The sodium copper rhubarb chlorophyll product provided by the present invention comprises the sodium copper rhubarb chlorophyll capsule described in the above technical solution.

[0036] The product and preparation method of the sodium copper rhubarb chlorophyll capsule of the present invention have been clearly described above and will not be repeated here.

[0037] The packaging of the present invention comprises an inner packaging material, a desiccant and an outer cover.

[0038] According to the present invention, the inner packaging material includes a polyvinyl chloride hard sheet and an aluminum foil; the implementation standards of the polyvinyl chloride hard sheet and the aluminum foil are YBB00212005-2015 and YBB00152002-2015 respectively.

[0039] The water vapor permeability of the polyethylene hard sheet is less than 2.5 g / m 2 .24h; the water vapor permeability of the aluminum foil is less than 0.5g / m 2 .24h.

[0040] The pharmaceutical polyethylene hard sheet of the present invention needs to have a low water vapor permeability, which is less than 2.5 g / m 2 .24h and aluminum foil need to have a low water vapor permeability, and the water vapor permeability of aluminum foil is less than 0.5g / m 2 .24h.

[0041] In some embodiments, the desiccant is a silica gel desiccant, a molecular sieve or calcium chloride; preferably a silica gel desiccant.

[0042] In some embodiments, the outer shell is a polyester / aluminum / polyethylene medicinal composite bag; wherein the implementation standard of polyester / aluminum / polyethylene is YBB00172002-2015.

[0043] The present invention uses medicinal polyvinyl chloride hard sheet and aluminum foil as inner packaging materials that directly contact the drug, and an outer polyester / aluminum / polyethylene medicinal composite bag, with a desiccant in the middle, thereby improving the high-temperature instability and improving the stability of the key quality attribute of the content of sodium copper rhubarb chlorophyll capsules in the quality control. The packaging form used in the present invention greatly improves the safety and effectiveness of the preparation.

[0044] The experimental results show that the quality characteristics of the rhubarb chlorophyll capsules are that the content of sodium copper chlorophyllin in the rhubarb chlorophyll capsules does not decrease by more than 10% in the accelerated 6-month and long-term 24-month periods. The content of sodium copper chlorophyllin in the rhubarb chlorophyll capsules in the full life cycle is between 95% and 105%.

[0045] The present invention solves the problem of degradation under high temperature conditions or during stability placement, and makes the sodium copper rhubarb chlorophyll capsules stable during stability placement; in a specific example, the content of the drug in the form of a packaging combination changes little under high temperature conditions, but the content of the same preparation using other packaging materials decreases significantly under high temperature conditions.

[0046] The present invention provides a sodium copper rhubarb chlorophyllin capsule, comprising the following raw materials in parts by weight: 100 parts of rhubarb; 50 parts of sodium copper chlorophyllin; 90-100 parts of excipients; 20-35 parts of disintegrants; and 1-3 parts of lubricants. The present invention prepares sodium copper rhubarb chlorophyllin capsules that meet quality requirements through a reasonable prescription combination. The problem of a significant reduction in the content of sodium copper chlorophyllin during the preparation process can be solved, and the quality and stability of the product are improved. The sodium copper rhubarb chlorophyllin capsules prepared by the present invention have better stability during the production, transportation, and use of the drug, and have no obvious changes during the placement process, which greatly improves the safety of the drug administration. Since the packaging combination avoids the influence of the air permeability / water permeability of the packaging material on the quality of the drug, the clinical use of the patient is safer and more stable. DETAILED DESCRIPTION

[0047] The present invention provides a sodium copper rhubarb chlorophyllin capsule and a preparation method thereof and a sodium copper rhubarb chlorophyllin product. Those skilled in the art can refer to the content of this article and appropriately improve the process parameters to achieve the desired effect. It should be particularly noted that all similar substitutions and modifications are obvious to those skilled in the art, and they all fall within the scope of protection of the present invention. The methods and applications of the present invention have been described through preferred embodiments, and relevant personnel can obviously modify or appropriately change and combine the methods and applications of this article without departing from the content, spirit and scope of the present invention to implement and apply the technology of the present invention.

[0048] It should be understood that the expression "one or more of..." includes each of the items recited after the expression individually and in various different combinations of two or more of the recited items, unless otherwise understood from the context and usage. The expression "and / or" in combination with three or more recited items should be understood to have the same meaning, unless otherwise understood from the context.

[0049] The use of the terms "comprising", "having" or "containing", including their grammatical synonyms, should generally be understood as open and non-restrictive, for example not excluding other unrecited elements or steps, unless otherwise specifically stated or otherwise understood from the context.

[0050] In this application, the term "and / or" describes the association relationship of associated objects, indicating that there may be three relationships. For example, A and / or B can represent: A exists alone, A and B exist at the same time, and B exists alone. A and B can be singular or plural.

[0051] In this application, "at least one" means one or more, "more than one" means two or more. "At least one of the following" or similar expressions refers to any combination of these items, including any combination of single or plural items.

[0052] It should be understood that the order of steps or the order in which certain actions are performed is not important as long as the present invention remains operable. In addition, two or more steps or actions may be performed simultaneously.

[0053] The use of any and all examples or exemplary language, such as "for example" or "including", herein is intended only to better illustrate the invention and does not limit the scope of the invention unless otherwise claimed. No language in this specification should be construed as indicating that any non-claimed element is essential to the practice of the invention.

[0054] In addition, the numerical ranges and parameters used to define the present invention are approximate values, and the relevant values ​​in the specific embodiments have been presented as accurately as possible. However, any numerical value inherently inevitably contains standard deviations due to individual test methods. Therefore, unless otherwise expressly stated, it should be understood that all ranges, quantities, values ​​and percentages used in this disclosure are modified by "about". Here, "about" generally means that the actual value is within plus or minus 10%, 5%, 1% or 0.5% of a specific value or range.

[0055] It should be understood that in the various embodiments of the present application, the size of the serial numbers of the above-mentioned processes does not mean the order of execution, some or all of the steps can be executed in parallel or sequentially, and the execution order of each process should be determined by its function and internal logic, and should not constitute any limitation on the implementation process of the embodiments of the present application.

[0056] Some cases are recorded in the embodiments and comparative examples of the present invention, wherein the embodiments show certain implementation modes of the present invention. However, this does not mean that the effects of the present invention can only be achieved in these cases.

[0057] In order to further illustrate the present invention, a sodium copper rhubarb chlorophyll capsule and a preparation method thereof and a sodium copper rhubarb chlorophyll product provided by the present invention are described in detail below in conjunction with examples.

[0058] The test materials used in the present invention are all common commercial products and can be purchased in the market.

[0059] Unless otherwise specified, the materials used in the present invention can all be purchased on the market.

[0060] Example 1

[0061] The formulation composition is as follows:

[0062] Table 1

[0063] Element Dosage rhubarb 100g Sodium Copper Chlorophyllin 50g Microcrystalline Cellulose 30g lactose 95g Magnesium Stearate 2g Empty capsules 1000 capsules

[0064] Sodium copper chlorophyllin is dissolved in purified water to prepare a 10% sodium copper chlorophyllin solution. Rhubarb (crushed and sieved), microcrystalline cellulose and lactose are added to a fluidized bed. The sodium copper chlorophyllin solution is added in the form of a spray and boiling granulation is performed. While adding, rapid boiling drying is performed at a medium to low temperature (55-60°C) until the sodium copper chlorophyllin solution is exhausted. Granulation is stopped when the moisture content of the material in the fluidized bed is ≤3%. The overall drying time is controlled to be ≤60 minutes. After granulation, a prescribed amount of magnesium stearate is added, mixed evenly, and filled into capsules.

[0065] Example 2

[0066] The formulation composition is as follows:

[0067] Table 2

[0068]

[0069]

[0070] Sodium copper chlorophyllin is dissolved in purified water to prepare a 10% sodium copper chlorophyllin solution. Rhubarb (crushed and sieved), starch and powdered sugar are added to a fluidized bed. The sodium copper chlorophyllin solution is added in the form of a spray and boiling granulation is performed. While adding, rapid boiling drying is performed at a medium to low temperature (55-60° C.) until the sodium copper chlorophyllin solution is exhausted. When the moisture content of the material in the fluidized bed is ≤3%, granulation is stopped. The overall drying time is controlled to be ≤60 minutes. A prescribed amount of magnesium stearate is added, mixed evenly, and capsules are filled to obtain the product.

[0071] Process Comparative Example 1:

[0072] The formulation composition is as follows:

[0073] Table 3

[0074] Element Dosage rhubarb 100g Sodium Copper Chlorophyllin 50g Microcrystalline Cellulose 30g lactose 95g Magnesium Stearate 2g Empty capsules 1000 capsules

[0075] Add sodium copper chlorophyllin, rhubarb (crushed and sieved), microcrystalline cellulose and lactose into the main mixing pot, mix at 10 r / min for 15 min, add magnesium stearate and continue mixing for 10 min, and fill the capsules to obtain the product.

[0076] Process Comparative Example 2:

[0077] The formulation composition is as follows:

[0078] Table 4

[0079] Element Dosage rhubarb 100g Sodium Copper Chlorophyllin 50g starch 30g Powdered sugar 95g Magnesium Stearate 2g Empty capsules 1000 capsules

[0080] Sodium copper chlorophyllin, rhubarb (crushed and sieved), powdered sugar and starch are added to a wet granulation pot, and purified water is sprayed into the pot for high-speed shear granulation. The granules are then dried in a boiling granulator at a drying temperature of 70-75°C, sieved through a 1.0 mm mesh, and magnesium stearate is added to the granules after granulation, mixed in a total mixing pot for 10 minutes, and then filled into capsules.

[0081] Process comparison example 3:

[0082] Element Dosage rhubarb 100g Sodium Copper Chlorophyllin 50g Microcrystalline Cellulose 30g lactose 95g Magnesium Stearate 2g Empty capsules 1000 capsules

[0083] Sodium copper chlorophyllin is dissolved in purified water to prepare a 10% sodium copper chlorophyllin solution. Rhubarb (crushed and sieved), microcrystalline cellulose and lactose are added to a fluidized bed. The sodium copper chlorophyllin solution is added in the form of a spray, and boiling granulation is performed. The sodium copper chlorophyllin solution is added while being dried at a low temperature (40-45°C) until the sodium copper chlorophyllin solution is exhausted. Granulation is stopped when the moisture content of the material in the fluidized bed is ≤3%. The overall drying time is 125 minutes. After granulation, a prescribed amount of magnesium stearate is added, mixed evenly, and filled into capsules.

[0084] Process Comparative Example 4:

[0085] Element Dosage rhubarb 100g Sodium Copper Chlorophyllin 50g Microcrystalline Cellulose 30g lactose 95g Magnesium Stearate 2g Empty capsules 1000 capsules

[0086] Sodium copper chlorophyllin is dissolved in purified water to prepare a 10% sodium copper chlorophyllin solution. Rhubarb (crushed and sieved), microcrystalline cellulose and lactose are added to a fluidized bed. The sodium copper chlorophyllin solution is added in the form of a spray, and boiling granulation is performed. The sodium copper chlorophyllin solution is added while drying at a medium-high temperature (65-75° C.) until the sodium copper chlorophyllin solution is exhausted. Granulation is stopped when the moisture content of the material in the fluidized bed is ≤3%. The overall drying time is controlled to be ≤40 minutes. After granulation, a prescribed amount of magnesium stearate is added, mixed evenly, and filled into capsules.

[0087] The results of the inspection of the packaging compositions of different embodiments and comparative examples, as well as the embodiments, are as follows:

[0088] Table 5 Content uniformity results of samples prepared by different production methods

[0089] Mixing uniformity Example 1 Process Comparative Example 1 1 102.04 93.04 2 102.95 102.01 3 104.05 102.40 4 101.88 89.46 5 104.58 105.43 6 101.75 95.78 7 104.77 106.61 8 101.48 90.12 9 102.05 104.32 10 101.72 94.69 Mean 102.73 98.39 RSD(%) 1.24 6.59

[0090] Table 6 Results of sample content detection using different granulation methods

[0091] Detection indicators Example 2 Process Comparative Example 2 Chlorophyllin sodium copper content (%) 101.13 90.3

[0092] Table 7 Test results of relevant indicators of samples with different granulation temperatures

[0093]

[0094] Table 8

[0095]

[0096]

[0097] The products were packaged according to Table 8, and placed under high temperature and high humidity conditions of 60℃ (RH92.5%±5%) for 10 days to examine the changes in the sodium copper chlorophyll content. At the same time, they were placed under long-term test (25℃±2℃, RH60%±5%) and accelerated test (40℃±2℃, RH75%±5%) conditions for 6 months to examine the changes in the sodium copper chlorophyll content.

[0098] Table 9 Influencing Factors Example / Packaging Comparative Example Chlorophyllin Sodium Copper Content Data

[0099]

[0100] Table 10 Long-term test example / comparative packaging example chlorophyll sodium copper content data

[0101]

[0102] Table 11 Accelerated test example / comparative example chlorophyll copper sodium content data

[0103]

[0104]

[0105] The difference between Example 1 and Example 2 is mainly in the selection of excipients, Example 1 is starch and powdered sugar, and Example 2 is lactose and microcrystalline cellulose. Among them, starch and powdered sugar are obviously hygroscopic and have poor fluidity, while lactose and microcrystalline cellulose are not hygroscopic and have good fluidity. It can be seen from the test results of Table 5 that the embodiment uses a boiling granulation process, and the process comparison example 1 does not use granulation and uses a mixing process. The test results show that even if a consistent excipient with good fluidity is used, the content uniformity result of the process comparison example 1 is significantly worse than that of Example 1, indicating that the selection of appropriate excipients and processes has an important impact on the quality of this product. The wet shear granulation process is compared with the boiling granulation. Because the shear granulation spraying, shear granulation and drying are longer in contact with water and the temperature is higher than that of the boiling granulation, it can be seen that the content is significantly reduced, indicating that moisture and high temperature may have an impact on product quality.

[0106] The difference between Example 1 and Process Comparison Examples 3 and 4 is mainly in the boiling drying temperature, which is low temperature, medium-low temperature and high temperature, respectively. The corresponding test results show that both too high and too low temperatures have an impact on the granulation effect, and the appearance of the obtained particles is different. If the boiling drying temperature is too low, the drying time is long and the obtained particles are larger, requiring subsequent treatment; if the boiling drying temperature is too high, the obtained particles are finer, and the sodium copper chlorophyllin cannot adhere to the auxiliary materials due to too fast drying, and a part of the sodium copper chlorophyllin and the auxiliary materials are lost, resulting in a decrease in yield. The comprehensive optimization of the boiling granulation drying temperature is 45-65°C.

[0107] Moisture and temperature have an impact on product quality, so choose packaging materials that are suitable for high humidity and high temperature conditions.

[0108] The high humidity test data shows that this product is not sensitive to high humidity conditions, and high humidity is not a sensitive condition that affects the quality change during the stability of this product. It can be found that the use of different excipients has no obvious effect on the stability of the finished preparation by using the packaging form of the present invention, indicating that this packaging form can well protect the preparation product, making it chemically stable during stability or use. The content of the final product decreased within 5% under accelerated and long-term inspection conditions, and the content was controlled at 95-105% during the entire inspection period, with stable quality.

[0109] When other packaging forms are used, it can be found that under high temperature and accelerated conditions, the content of sodium copper chlorophyllin decreases significantly and does not meet the standard limit, indicating that the packaging form of the present invention is more suitable and can well protect the stability of the product during transportation and storage.

[0110] In summary, the composition, production method and packaging form of the composition described in the present invention can improve the quality and safety of drugs.

[0111] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A sodium copper rhubarb chlorophyll capsule, characterized in that: The invention comprises the following raw materials in parts by weight: 100 parts of rhubarb; 50 parts of sodium copper chlorophyllin; 90-100 parts of excipients; 20-35 parts of disintegrants; and 1-3 parts of lubricants.

2. The sodium copper rhubarb chlorophyll capsule according to claim 1, characterized in that: The excipients include lactose, sucrose or maltose; The disintegrant is microcrystalline cellulose, straight-chain starch or amylopectin; the lubricant is magnesium stearate, stearic acid or silicon dioxide.

3. A method for preparing sodium copper rhubarb chlorophyll capsules, characterized in that: The steps include: A) adding rhubarb, disintegrant and excipient into a fluidized bed; adding sodium copper chlorophyllin solution by spraying; and then performing boiling granulation; B) Lubricant is added to the granulated material, mixed, and filled into capsules.

4. The preparation method according to claim 3, characterized in that: The temperature of the boiling granulation is 45-65° C., and the time of the boiling granulation is ≤60 min. The granulation is stopped when the moisture content of the material in the fluidized bed is ≤3%.

5. The preparation method according to claim 3, characterized in that: The effective component content of the material is not less than 97%, and the content uniformity RSD is ≤2%.

6. A sodium copper rhubarb chlorophyll capsule, characterized in that: The compound is prepared by the preparation method according to any one of claims 3 to 5.

7. A sodium copper rhubarb chlorophyllin product, characterized in that: The sodium copper rhubarb chlorophyllin capsule and packaging according to claim 6; The package comprises an inner packaging material, a desiccant and an outer jacket.

8. The product according to claim 7, characterized in that The inner packaging material includes a polyvinyl chloride hard sheet and an aluminum foil; The water vapor permeability of the polyethylene hard sheet is less than 2.5 g / m 2 .24h; the water vapor permeability of the aluminum foil is less than 0.5g / m 2 .24h.

9. The product according to claim 7, characterized in that The desiccant is a silica gel desiccant, a molecular sieve or calcium chloride.

10. The product according to claim 7, characterized in that The outer shell is a polyester / aluminum / polyethylene medicinal composite bag; the implementation standard of polyester / aluminum / polyethylene is YBB00172002-2015.

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