Compound preparation for promoting rumination of ruminants

Abstract

The invention belongs to the field of veterinary drugs, and provides a compound preparation for promoting rumination of ruminants, which is prepared from the following medicaments by weight: 4-7 g of veratrum nigrum, 0.1-0.2 g of yucca extract, 0.05-0.1 g of concentrated sodium chloride, 0.1-0.3 g of bighead atractylodes rhizome, 0.2-0.5 g of pericarpium citri reticulatae, 0.2-0.5 g of medicated leaven and 0.6-1.2 g of yeast culture. The preparation method comprises the following steps: selecting veratrum nigrum roots or whole herbs with roots, cleaning and drying bighead atractylodes rhizome and dried orange peel, carrying out wall breaking treatment, removing large or small particles through a screen to ensure uniform particle size, mixing all the medicaments, granulating, drying and finishing the granules, mixing with superfine silica powder and sodium stearate, and uniformly mixing, thereby obtaining the drug for treating the hyperlipidemia, hyperlipidemia, hyperlipidemia, hyperlipidemia, hyperlipidemia and hyperlipidemia. Finally, tabletting and coating are conducted through a tabletting machine and a coating machine, the overall preparation process is completed after packaging, the number and vitality of microorganisms in the rumen are improved through metabolites of the yeast culture, the digestion and utilization efficiency of the feed is improved, rumen peristalsis is increased through all the Chinese herbal medicine components, and digestive juice secretion is promoted.

Description

Technical Field

[0001] The invention belongs to the field of veterinary medicine, in particular to a compound preparation for promoting rumination of ruminants. Background Art

[0002] Indigestion in ruminants is often found in clinical practice, which can lead to loss of appetite, decreased production performance, etc., causing economic losses to farmers and even affecting the development of animal husbandry.

[0003] This paragraph may cite existing authorized patents, (for example: in the Chinese patent with publication number CN104998265A, a method for preparing a compound Chinese herbal medicine for promoting rumination in ruminants and its extract is mentioned, which comprises the following components by weight: 2-4 parts of Shenqu, 2-4 parts of Cimicifuga and Hawthorn, 2-4 parts of malt, 3-6 parts of dried tangerine peel and 1-4 parts of antihistamines / dopamine receptor antagonists. The present invention has the effects of appetizing, strengthening the spleen, promoting rumination, etc., and is mainly used to treat various diseases caused by reduced digestive tract function, rumen food accumulation, rumen flatulence, and non-rumination. When Chinese medicine is added to ruminant digestive disorders, the effect is more obvious, the onset time is faster, and the cure rate is higher. The product of the present invention has good efficacy, is safe and reliable, non-toxic, harmless, and residue-free, has a simple process, low cost, and strong practicality.

[0004] Western medicines that promote ruminant motility have disadvantages such as large side effects and residues, while Chinese medicines are slow in effect and difficult to take. The present invention combines Chinese medicine and chemical medicines in one, with scientific and sophisticated formulas and simple and reasonable production methods. The ruminant produced by the production method of the present invention has the advantages of both Chinese and Western medicines, and the side effects are relatively offset. The therapeutic effects complement each other, complement each other, have good effects, take effect quickly, and have a long-lasting effect. It is an ideal Chinese and Western combined ruminant and its production method. Summary of the invention

[0005] In order to solve the above technical problems, the present invention provides a compound preparation for promoting rumination in ruminants, so as to solve the disadvantages of western medicine for promoting ruminant motility in the prior art, such as large side effects and residues, and the problems of slow effect and difficulty in taking traditional Chinese medicine.

[0006] A compound preparation for promoting rumination in ruminants, comprising the following agents according to weight ratio: 4-7g of Veratrum, 0.1-0.2g of yucca extract, 0.05-0.1g of concentrated sodium chloride, 0.1-0.3g of Atractylodes macrocephala, 0.2-0.5g of dried tangerine peel, 0.2-0.5g of Liushenqu, and 0.6-1.2g of yeast culture.

[0007] Preferably, the method comprises the following preparation steps:

[0008] S1. Raw material pretreatment: wash Veratrum, yucca, Atractylodes macrocephala, and dried orange peel;

[0009] S2, extraction: preparing 3-6 portions of yucca to extract yucca extract;

[0010] S3, wall breaking and screening: the dried Veratrum, Atractylodes macrocephala, and dried orange peel are broken, and then the larger or smaller particles are removed through a sieve to ensure uniform particle size;

[0011] S4, mixing and granulating: the wall-broken Veratrum, Atractylodes macrocephala, dried orange peel, Yucca schidigera extract, Liushenqu, and yeast culture are fully stirred and dry-mixed for 15 minutes, and then concentrated sodium chloride is added and fully stirred and wet-mixed for 10 minutes to form wet granules;

[0012] S5. Drying: Dry the wet particles at high temperature to remove excess water, reduce the water content of the particles, and improve the hardness and stability of the particles;

[0013] S6. Granulation: The dried granules are passed through a sieve and a cutter to adjust the size and shape of the granules, and the granules that do not meet the requirements are removed to ensure the quality and fluidity of the granules;

[0014] S7, total mixing: the granules after granulation are mixed with the anti-adherent agent and lubricant again to achieve the fluidity and compressibility required for tableting;

[0015] S8, tableting and coating: the mixed granules are compressed in a tablet press to form tablets with a certain shape, size, weight and hardness, and the tablets are coated in a coating machine to form a thin film to improve the stability and release performance of the tablets;

[0016] S9. Packaging: Seal and package the coated tablets according to certain specifications and quantities.

[0017] Preferably, the extraction and preparation method of yucca in S2 comprises the following steps:

[0018] S201, chopping the washed yucca stems and leaves, and soaking and extracting them with methanol solvent to obtain yucca concentrate;

[0019] S202, mixing the yucca concentrate with water, and then adding n-butanol to perform two-phase extraction to separate an aqueous phase and an n-butanol phase;

[0020] S203, evaporating the n-butanol phase to dryness to obtain a crude extract;

[0021] S204, refluxing the crude extract with ether to remove impurities dissolved in ether, and obtaining ether-insoluble matter, which is the yucca extract.

[0022] Preferably, the wet granules in S5 are dried at a high temperature of 70-80 degrees Celsius.

[0023] Preferably, the anti-sticking agent used in S7 is micro-powdered silica gel, and the lubricant is sodium stearate.

[0024] Compared with the prior art, the present invention has the following beneficial effects:

[0025] 1. The present invention selects the root of Veratrum or the whole plant with the root, washes and dries it, and performs wall-breaking treatment on Atractylodes macrocephala and dried tangerine peel, removes larger or smaller particles through a sieve to ensure uniform particle size, mixes all the agents and granulates them, and after drying the whole particles, mixes them with micro-powder silica gel and sodium stearate, and finally performs tablet compression and coating through a tablet press and a coating machine, and completes the overall preparation process after packaging, and increases the number and activity of microorganisms in the rumen through the metabolic products of yeast culture, improves the digestion and utilization efficiency of feed, and increases rumen peristalsis through various components of Chinese herbal medicine to promote the secretion of digestive juice.

[0026] 2. The present invention adopts yucca extract as a component of the preparation. After the yucca is washed and chopped, it is extracted and concentrated by an alcohol solvent, and then impurities are removed by two-phase extraction with water and n-butanol. The n-butanol phase is evaporated to dryness and then refluxed with ether to obtain the ether insoluble matter, which is the yucca extract required by the preparation. The yucca extract has the effects of reducing ammonia emissions in the intestine of animals, avoiding intestinal ammonia damage to mucosal epithelial tissues, accelerating the physiological metabolism of mucosal cells, and promoting the digestion and absorption of feed by ruminants. At the same time, it can also regulate the intestinal microenvironment and has the effects of inhibiting bacteria and improving immune function. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 It is a flowchart of the steps of the method for preparing the compound preparation of the present invention;

[0028] Figure 2 The figure is a flowchart of the steps of extracting the yucca extract of the present invention. DETAILED DESCRIPTION

[0029] The following embodiments of the present invention are described in further detail in conjunction with the accompanying drawings and examples. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0030] As attached Figure 1 To Attachment Figure 2 As shown:

[0031] Embodiment 1: The present invention provides a compound preparation for promoting rumination in ruminants, comprising 4-7 g of Veratrum, 0.1-0.2 g of yucca extract, 0.05-0.1 g of concentrated sodium chloride, 0.1-0.3 g of Atractylodes macrocephala, 0.2-0.5 g of dried tangerine peel, 0.2-0.5 g of Liushenqu, and 0.6-1.2 g of yeast culture.

[0032] Specifically, the method comprises the following preparation steps:

[0033] S1. Raw material pretreatment: wash Veratrum, yucca, Atractylodes macrocephala, and dried orange peel;

[0034] S2, extraction: preparing 3-6 portions of yucca to extract yucca extract;

[0035] S3, wall breaking and screening: the dried Veratrum, Atractylodes macrocephala, and dried orange peel are broken, and then the larger or smaller particles are removed through a sieve to ensure uniform particle size;

[0036] S4, mixing and granulating: the wall-broken Veratrum, Atractylodes macrocephala, dried orange peel, Yucca schidigera extract, Liushenqu, and yeast culture are fully stirred and dry-mixed for 15 minutes, and then concentrated sodium chloride is added and fully stirred and wet-mixed for 10 minutes to form wet granules;

[0037] S5. Drying: Dry the wet particles at high temperature to remove excess water, reduce the water content of the particles, and improve the hardness and stability of the particles;

[0038] S6. Granulation: The dried granules are passed through a sieve and a cutter to adjust the size and shape of the granules, and the granules that do not meet the requirements are removed to ensure the quality and fluidity of the granules;

[0039] S7, total mixing: the granules after granulation are mixed with the anti-adherent agent and lubricant again to achieve the fluidity and compressibility required for tableting;

[0040] S8, tableting and coating: the mixed granules are compressed in a tablet press to form tablets with a certain shape, size, weight and hardness, and the tablets are coated in a coating machine to form a thin film to improve the stability and release performance of the tablets;

[0041] S9. Packaging: Seal and package the coated tablets according to certain specifications and quantities.

[0042] Specifically, the wet granules in S5 are dried at a high temperature of 70-80 degrees Celsius.

[0043] Specifically, the anti-sticking agent used in S7 is micro powder silica gel, and the lubricant is sodium stearate.

[0044] From the above, it can be seen that the root of Veratrum or the whole plant with root is selected for washing and drying, and the wall of Atractylodes macrocephala and dried tangerine peel is broken, and large or small particles are removed through a sieve to ensure uniform particle size, all the agents are mixed and granulated, and the whole particles are dried and mixed with micro-powder silica gel and sodium stearate, and finally tableted and coated by a tablet press and a coating machine. After packaging, the overall preparation process is completed, and the metabolic products of yeast culture are used to increase the number and activity of microorganisms in the rumen, improve the digestion and utilization efficiency of feed, and increase rumen motility through the various components of Chinese herbal medicine to promote the secretion of digestive juice.

[0045] Embodiment 2: This embodiment is basically the same as the previous embodiment, except that the extraction and preparation method of yucca in S2 is as follows:

[0046] S201, chopping the washed yucca stems and leaves, and soaking and extracting them with methanol solvent to obtain yucca concentrate;

[0047] S202, mixing the yucca concentrate with water, and then adding n-butanol to perform two-phase extraction to separate an aqueous phase and an n-butanol phase;

[0048] S203, evaporating the n-butanol phase to dryness to obtain a crude extract;

[0049] S204, refluxing the crude extract with ether to remove impurities dissolved in ether, and obtaining ether-insoluble matter, which is the yucca extract.

[0050] From the above, it can be seen that one of the components of this preparation is yucca extract. After the yucca is washed and chopped, it is extracted and concentrated by alcohol solvent, and then impurities are removed by two-phase extraction with water and n-butanol. The n-butanol phase is evaporated and refluxed with ether to obtain the ether insoluble matter, which is the yucca extract required for this preparation. It has the effects of reducing ammonia emissions in the intestines of animals, avoiding intestinal ammonia damage to mucosal epithelial tissues, accelerating the physiological metabolism of mucosal cells, and promoting ruminant animals' digestion and absorption of feed. At the same time, it can also regulate the intestinal microenvironment and has the effects of antibacterial and enhancing immune function.

[0051] Effect embodiment, the results are as follows: Inner Mongolia farmers have 200 cattle, due to excessive feed intake, 124 of them showed non-rumination symptoms, of which 62 were taken with the preparation disclosed in the present invention.

[0052] Results: 20 minutes after medication, 46 cows showed rumination symptoms, and 35 minutes later, the remaining 16 cows showed rumination symptoms, with obvious effects.

[0053] The embodiments of the present invention are provided for the purpose of illustration and description. Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are exemplary and cannot be understood as limitations of the present invention. Ordinary technicians in this field can change, modify, replace and modify the above embodiments within the scope of the present invention.

Claims

1. A compound preparation for promoting rumination in ruminants, characterized in that: The drug is composed of the following agents in weight ratio: 4-7g of Veratrum, 0.1-0.2g of yucca extract, 0.05-0.1g of concentrated sodium chloride, 0.1-0.3g of Atractylodes macrocephala, 0.2-0.5g of dried tangerine peel, 0.2-0.5g of Liushenqu, and 0.6-1.2g of yeast culture.

2. A compound preparation for promoting rumination in ruminants as claimed in claim 1, characterized in that: The method comprises the following preparation steps: S1. Raw material pretreatment: wash Veratrum, yucca, Atractylodes macrocephala, and dried orange peel; S2, extraction: preparing 3-6 portions of yucca to extract yucca extract; S3, wall breaking and screening: the dried Veratrum, Atractylodes macrocephala, and dried orange peel are broken, and then the larger or smaller particles are removed through a sieve to ensure uniform particle size; S4, mixing and granulating: the wall-broken Veratrum, Atractylodes macrocephala, dried orange peel, Yucca schidigera extract, Liushenqu, and yeast culture are fully stirred and dry-mixed for 15 minutes, and then concentrated sodium chloride is added and fully stirred and wet-mixed for 10 minutes to form wet granules; S5. Drying: Dry the wet particles at high temperature to remove excess water, reduce the water content of the particles, and improve the hardness and stability of the particles; S6. Granulation: The dried granules are passed through a sieve and a cutter to adjust the size and shape of the granules, and the granules that do not meet the requirements are removed to ensure the quality and fluidity of the granules; S7, total mixing: the granules after granulation are mixed with the anti-adherent agent and lubricant again to achieve the fluidity and compressibility required for tableting; S8, tableting and coating: the mixed granules are compressed in a tablet press to form tablets with a certain shape, size, weight and hardness, and the tablets are coated in a coating machine to form a thin film to improve the stability and release performance of the tablets; S9. Packaging: Seal and package the coated tablets according to certain specifications and quantities.

3. A compound preparation for promoting rumination in ruminants as claimed in claim 2, characterized in that: The extraction and preparation method of yucca in S2 comprises the following steps: S201, chopping the washed yucca stems and leaves, and soaking and extracting them with methanol solvent to obtain yucca concentrate; S202, mixing the yucca concentrate with water, and then adding n-butanol to perform two-phase extraction to separate an aqueous phase and an n-butanol phase; S203, evaporating the n-butanol phase to dryness to obtain a crude extract; S204, refluxing the crude extract with ether to remove impurities dissolved in ether, and obtaining ether-insoluble matter, which is the yucca extract.

4. A compound preparation for promoting rumination in ruminants as claimed in claim 2, characterized in that: The wet granules in S5 are dried at a high temperature of 70-80 degrees Celsius.

5. A compound preparation for promoting rumination in ruminants as claimed in claim 2, characterized in that: The anti-sticking agent used in S7 is micro-powder silica gel, and the lubricant is sodium stearate.

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