Stock solution treatment device, method for operating stock solution treatment device, and method for cleaning appliance

Abstract

Provided are a stock solution treatment device, a method for operating a stock solution treatment device, and a method for cleaning an instrument, with which it is possible to shorten the treatment time of a stock solution extracted from the body of a patient and to improve the workability of a worker. The device is provided with a main body part (11) having a hollow space therein, and a hollow fiber membrane (16) provided in the hollow space of the main body part (11). A cleaning liquid is caused to flow through the hollow fiber membrane (16) in a state in which the interior of the hollow space (12h) of the main body section (11) and / or the interior of the hollow fiber membrane (16) is filled with the liquid to fill the region of the hollow fiber membrane (16) to be cleaned. The effects of eliminating clogging of the hollow fiber membrane (16) and removing substances accumulated in the hollow fiber membrane (16) or the interior of the main body part (11) can be improved.

Description

[0001] This invention application is a divisional application filed based on the Chinese invention application that entered the Chinese national phase of the international application with PCT application number PCT / JP2019 / 032204 and the subject matter of “raw liquid treatment device, operation method of raw liquid treatment device and cleaning method of apparatus”. The application number of the Chinese invention application is 201980058425.9 and the application date is August 17, 2019. Technical Field

[0002] The present invention relates to a stock solution treatment device, an operating method of the stock solution treatment device, and a method for cleaning an instrument. More specifically, it relates to a stock solution treatment device for obtaining a treated liquid, which is a treated liquid for intravenous infusion by filtering or concentrating a stock solution such as pleural effusion accumulated in the chest or abdomen in carcinomatous pleuroperitoneitis, liver cirrhosis, etc., or waste plasma in plasma exchange therapy, and a method for cleaning an instrument used in the stock solution treatment device. Background Art

[0003] In cancerous pleuroperitoneitis, liver cirrhosis, etc., pleural effusion or peritoneal effusion may accumulate in the pleural cavity or abdominal cavity. When such pleural effusion accumulates, the pleural effusion may compress the surrounding internal organs. In order to improve such problems, pleural effusion may be extracted by puncture.

[0004] On the other hand, the pleural and abdominal effusion contains part or all of the plasma components exuded from the blood, and the plasma contains major proteins (e.g., albumin, globulin, etc.). Although the above symptoms can be improved by extracting the pleural and abdominal effusion, components useful to the human body such as protein are lost along with water. Therefore, it is necessary to supplement the lost components by administering albumin preparations, globulin preparations, etc. intravenously.

[0005] However, although specific components can be supplemented by intravenously administering albumin preparations, globulin preparations, etc., the preparations are expensive, and the cost of treatment becomes very high.

[0006] Furthermore, since only a limited amount of specific components among the lost components can be supplied, there is a possibility of problems such as nutritional deficiencies and susceptibility to infection.

[0007] Therefore, a treatment method has been developed in which a treated solution extracted from the pleural effusion or peritoneal effusion (hereinafter sometimes referred to as the stock solution) is administered intravenously, namely the so-called Cell-free and Concentrated Ascites Reinfusion Therapy (CART). In the case of such CART, most of the effective components other than the cellular components contained in the pleural effusion and peritoneal effusion can be returned to the patient's body, so it is possible to effectively supply the patient with the components lost from the blood without being limited to specific components. Moreover, even if the concentrated solution is administered, as long as the insufficient components are supplemented by the preparation in a manner corresponding to the insufficient amount, the use of albumin preparations, etc. can be reduced as much as possible, thereby suppressing the cost of treatment.

[0008] In CART, a treatment fluid is generated and returned to the patient's body by filtering and concentrating pleural effusion or peritoneal effusion. In a treatment device that generates such a treatment fluid, a raw fluid such as pleural effusion or peritoneal effusion is supplied to a filter having a filtration component such as a hollow fiber membrane or a plate-shaped permeable membrane to separate the liquid component (hereinafter sometimes referred to as the filtrate). If the separated filtrate is passed through a concentrator to remove water from the filtrate, a concentrated solution can be obtained after the filtrate is concentrated, that is, the above-mentioned treatment fluid can be obtained (see patent documents 1 to 4).

[0009] Prior art literature

[0010] Patent Literature

[0011] Patent Document 1: Japanese Patent No. 5062631

[0012] Patent Document 2: Japanese Patent Application Publication No. 2015-126763

[0013] Patent Document 3: Japanese Patent Application Publication No. 2019-13487

[0014] Patent Document 4: Japanese Patent Application Publication No. 2019-13488 Summary of the invention

[0015] Technical problem to be solved by the invention

[0016] As described above, in CART, the treated liquid obtained by treating the raw liquid extracted from the patient's body is returned to the patient's body, but if the filter and the concentrator are clogged, the raw liquid cannot be properly treated. Therefore, in order to eliminate the clogging of the filter and the concentrator, it is required to properly clean the filter and the concentrator.

[0017] In view of such circumstances, the present invention aims to provide a raw liquid processing device, an operating method of the raw liquid processing device, and a cleaning method of an instrument that can shorten the processing time of raw liquid extracted from a patient's body and improve the workability of the operator.

[0018] Solutions for solving the above technical problems

[0019] <How to clean the equipment>

[0020] The first invention is a method for cleaning an apparatus, wherein the apparatus is an apparatus having a main body having a hollow space inside and a hollow fiber membrane arranged in the hollow space of the main body, and is characterized in that when cleaning the hollow fiber membrane in the apparatus, a liquid is caused to flow in the following manner: the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the area to be cleaned in the hollow fiber membrane is filled, and the liquid is allowed to pass through the hollow fiber membrane.

[0021] The cleaning method of the apparatus of the second invention is characterized in that, in the first invention, when cleaning the hollow fiber membrane in the apparatus, the liquid is caused to flow in the following manner: after the hollow space of the main body and / or the hollow fiber membrane is filled with the liquid until the area to be cleaned in the hollow fiber membrane is filled, the liquid is allowed to pass through the hollow fiber membrane.

[0022] The cleaning method of the apparatus of the third invention is characterized in that, in the first invention or the second invention, the apparatus comprises: a first liquid supply part, which is connected to the first end of the hollow fiber membrane and supplies the exhaust fluid between the inside and the outside of the hollow fiber membrane; a second liquid supply part, which is connected to the second end of the hollow fiber membrane and supplies the exhaust fluid between the inside and the outside of the hollow fiber membrane; a port, which supplies the exhaust fluid between the hollow space of the main body and the outside, and in a state where the hollow fiber membrane is arranged in an axial direction toward the up and down direction, the liquid is made to flow in the following manner: the hollow space of the main body and / or the hollow fiber membrane is filled with the liquid until the hollow fiber membrane is immersed in the liquid in whole or in part, and the liquid passes through the hollow fiber membrane in this state.

[0023] The cleaning method of the apparatus of the 4th invention is characterized in that, in the 1st invention or the 2nd invention, the apparatus comprises: a first liquid supply part, which is connected to the first end of the hollow fiber membrane and supplies the exhaust fluid between the inside and the outside of the hollow fiber membrane; a second liquid supply part, which is connected to the second end of the hollow fiber membrane and supplies the exhaust fluid between the inside and the outside of the hollow fiber membrane; a port, which supplies the exhaust fluid between the hollow space of the main body and the outside, and in a state where the hollow fiber membrane is arranged in a horizontal direction in the axial direction, the liquid is made to flow in the following manner: the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the hollow fiber membrane is immersed in the liquid in whole or in part, and the liquid passes through the hollow fiber membrane in this state.

[0024] The cleaning method of the apparatus of the fifth invention is characterized in that, in the first, second, third or fourth invention, the apparatus comprises: a first liquid supply part, which is connected to the first end of the hollow fiber membrane and supplies a discharge fluid between the inside and the outside of the hollow fiber membrane; a second liquid supply part, which is connected to the second end of the hollow fiber membrane and supplies a discharge fluid between the inside and the outside of the hollow fiber membrane; a port, which supplies a discharge fluid between the hollow space of the main body and the outside, and discharges liquid from the first liquid supply part and / or the second liquid supply part when liquid is supplied from the port, or discharges liquid from the port when liquid is supplied from the first liquid supply part and / or the second liquid supply part.

[0025] <Operation method (cleaning method) of the stock solution treatment device>

[0026] The operating method of the raw liquid processing device of the sixth invention is an operating method of a device for concentrating raw liquid to form a concentrated liquid, characterized in that the device comprises: a filter having a filtering component for filtering the raw liquid; a concentrator supplied with a filtrate filtered by the filter and concentrating the filtrate to form the concentrated liquid; a raw liquid supply unit for supplying the raw liquid to the filter; a liquid supply flow path for connecting the raw liquid supply unit with the raw liquid supply port of the filter; a filtrate supply flow path for connecting the filtrate discharge port of the filter with the filtrate supply port of the concentrator; a concentrated liquid flow path connected to the concentrated liquid discharge port of the concentrator; and a waste liquid flow path connected to the waste liquid discharge port. The waste liquid outlet discharges the waste liquid separated from the concentrated liquid in the concentrator; a liquid delivery unit delivers liquid to each flow path; a control unit controls the operation of the liquid delivery unit, the filter and / or the concentrator comprises a main body having a hollow space inside and a hollow fiber membrane arranged in the hollow space of the main body, and when cleaning the hollow fiber membrane in the filter and / or the concentrator, the control unit controls the operation of the liquid delivery unit so that the liquid passes through the hollow fiber membrane in a state in which the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the area to be cleaned in the hollow fiber membrane is filled.

[0027] The operating method of the raw liquid treatment device of the 7th invention is characterized in that, in the 6th invention, when cleaning the hollow fiber membrane in the filter and / or the concentrator, the control unit controls the operation of the liquid delivery unit so that the liquid passes through the hollow fiber membrane after the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the area to be cleaned in the hollow fiber membrane is filled.

[0028] The operating method of the raw liquid treatment device of the 8th invention is characterized in that, in the 6th invention or the 7th invention, the filter is configured so that the axial direction of the hollow fiber membrane is in the up and down direction, and is provided with a port, and the port is arranged above the raw liquid supply port or the filtrate discharge port when cleaning the hollow fiber membrane in the filter, and can connect the hollow space of the main body with the outside, and the control unit controls the operation of the liquid delivery unit so that the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the hollow fiber membrane is completely or partially immersed in the liquid, so that the liquid passes through the hollow fiber membrane of the filter in this state.

[0029] The operating method of the raw liquid treatment device of the 9th invention is characterized in that, in the 6th, 7th or 8th invention, the concentrator is configured so that the axial direction of the hollow fiber membrane is in the up and down direction, and has a port, and the port is arranged above the concentrated liquid discharge outlet or the waste liquid discharge outlet when cleaning the hollow fiber membrane in the concentrator, and can connect the hollow space of the main body with the outside, and the control unit controls the operation of the liquid delivery unit so that the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the hollow fiber membrane is completely or partially immersed in the liquid, so that the liquid passes through the hollow fiber membrane of the concentrator in this state.

[0030] The operating method of the raw liquid treatment device of the tenth invention is characterized in that, in the sixth invention or the seventh invention, when the filter and / or the concentrator is configured in a manner that the axial direction of the hollow fiber membrane is oriented in a horizontal direction, the control unit controls the operation of the liquid delivery unit so that the hollow space of the main body is filled with liquid until the hollow fiber membrane is entirely or partially immersed in the liquid, and the liquid passes through the hollow fiber membrane in this state.

[0031] The operating method of the raw liquid treatment apparatus according to the eleventh invention is characterized in that, in the sixth, seventh, eighth, ninth or tenth invention, the liquid is supplied into the concentrator from the filtrate supply port or the concentrated liquid discharge port.

[0032] <Operation method of raw liquid treatment device>

[0033] The operating method of the raw liquid treatment device of the 12th invention is an operating method of a device for concentrating raw liquid to form concentrated liquid, characterized in that the device comprises: a filter having a filtering component for filtering the raw liquid; a concentrator supplied with a filtrate filtered by the filter and concentrating the filtrate to form the concentrated liquid; a raw liquid supply unit for supplying the raw liquid to the filter; a liquid supply flow path for connecting the raw liquid supply unit with a raw liquid supply port of the filter; a filtrate supply flow path for connecting a filtrate discharge port of the filter with a filtrate supply port of the concentrator; a concentrated liquid flow path connected to a concentrated liquid discharge port of the concentrator; a waste liquid flow path connected to a waste liquid discharge port, the waste liquid discharge port discharges the waste liquid separated from the concentrated liquid in the concentrator; a liquid supply unit for supplying liquid to each flow path; and a control unit for controlling the operation of the liquid supply unit to adjust the liquid supply amount from the filter to the concentrator and / or the concentration ratio of the concentrated liquid based on the filter membrane differential pressure of the filter and / or the concentrator membrane differential pressure of the concentrator.

[0034] The operating method of the raw liquid treatment device of the 13th invention is characterized in that, in the 12th invention, the liquid supply section includes a liquid supply channel liquid supply section arranged in the liquid supply channel, and a concentrated liquid channel liquid supply section arranged in the concentrated liquid channel or a waste liquid channel liquid supply section arranged in the waste liquid channel, and when the differential pressure between the filter membranes is less than the set differential pressure of the filter, the liquid supply amount of the raw liquid to the filter is increased, when the differential pressure between the filter membranes is within the range of the set differential pressure of the filter, the liquid supply amount of the raw liquid to the filter is maintained, and when the differential pressure between the filter membranes is greater than the set differential pressure of the filter, the liquid supply amount of the raw liquid to the filter is reduced.

[0035] The operating method of the raw liquid treatment device of the 14th invention is characterized in that, in the 12th invention or the 13th invention, the liquid supply section includes a liquid supply flow path liquid supply section arranged in the liquid supply flow path, and a concentrated liquid flow path liquid supply section arranged in the concentrated liquid flow path or a waste liquid flow path liquid supply section arranged in the waste liquid flow path, and when the differential pressure between the concentrator membranes of the concentrator is less than the set differential pressure, the liquid supply amount from the filter to the concentrator is increased, when the differential pressure between the concentrator membranes of the concentrator is within the range of the set differential pressure, the liquid supply amount from the filter to the concentrator is maintained, and when the differential pressure between the concentrator membranes of the concentrator is greater than the set differential pressure, the liquid supply amount from the filter to the concentrator is reduced.

[0036] The operating method of the raw liquid treatment device of the 15th invention is characterized in that, in the 12th, 13th or 14th invention, the liquid supply section includes a liquid supply section arranged in the liquid supply section, and a concentrated liquid section arranged in the concentrated liquid section or a waste liquid section arranged in the waste liquid section, and when the differential pressure between the concentrator membranes of the concentrator is less than the set differential pressure, the flow rate of the concentrated liquid section is reduced or the flow rate of the waste liquid section is increased; when the differential pressure between the concentrator membranes of the concentrator is within the range of the set differential pressure, the flow rates of the concentrated liquid section and the waste liquid section are maintained; when the differential pressure between the concentrator membranes of the concentrator is greater than the set differential pressure, the flow rate of the concentrated liquid section is increased or the flow rate of the waste liquid section is reduced.

[0037] The operating method of the raw liquid treatment device of the 16th invention is characterized in that, in the 12th invention, the liquid supply section includes a filtrate supply flow path liquid supply section arranged in the filtrate supply flow path, and a concentrated liquid flow path liquid supply section arranged in the concentrated liquid flow path or a waste liquid flow path liquid supply section arranged in the waste liquid flow path, and when the differential pressure between the filter membranes is smaller than the set differential pressure of the filter, the liquid supply amount of the filtrate to the concentrator is increased, when the differential pressure between the filter membranes is within the range of the set differential pressure of the filter, the liquid supply amount of the filtrate to the concentrator is maintained, and when the differential pressure between the filter membranes is greater than the set differential pressure of the filter, the liquid supply amount of the filtrate to the concentrator is reduced.

[0038] The operating method of the raw liquid treatment device of the 17th invention is characterized in that, in the 12th invention or the 16th invention, the liquid supply section includes a filtrate supply flow path liquid supply section arranged in the filtrate supply flow path, and a concentrated liquid flow path liquid supply section arranged in the concentrated liquid flow path or a waste liquid flow path liquid supply section arranged in the waste liquid flow path, and when the differential pressure between the membranes of the concentrator is less than the set differential pressure of the concentrator, the liquid supply amount of the concentrated liquid in the concentrated liquid flow path is reduced or the liquid supply amount of the waste liquid in the waste liquid flow path is increased, and when the differential pressure between the membranes of the concentrator is within the range of the set differential pressure of the concentrator, the liquid supply amounts of the concentrated liquid in the concentrated liquid flow path and the waste liquid flow path are maintained, and when the differential pressure between the membranes of the concentrator is greater than the set differential pressure of the concentrator, the liquid supply amount of the concentrated liquid in the concentrated liquid flow path is increased or the liquid supply amount of the waste liquid in the waste liquid flow path is reduced.

[0039] The operating method of the raw liquid treatment device of the 18th invention is characterized in that, in the 12th, 16th or 17th invention, the liquid supply section includes a filtrate supply flow path liquid supply section arranged in the filtrate supply flow path, and a concentrated liquid flow path liquid supply section arranged in the concentrated liquid flow path or a waste liquid flow path liquid supply section arranged in the waste liquid flow path, and when the differential pressure between the membranes of the concentrator is less than the set differential pressure of the concentrator, the liquid supply amount of the filtrate to the concentrator is increased, when the differential pressure between the membranes of the concentrator is within the range of the set differential pressure of the concentrator, the liquid supply amount of the filtrate to the concentrator is maintained, and when the differential pressure between the membranes of the concentrator is greater than the set differential pressure of the concentrator, the liquid supply amount of the filtrate to the concentrator is reduced.

[0040] The operating method of the raw liquid treatment device of the 19th invention is characterized in that, in the 12th invention, the liquid supply section includes a concentrated liquid flow path liquid supply section arranged in the concentrated liquid flow path and a waste liquid flow path liquid supply section arranged in the waste liquid flow path, and when the differential pressure between the filter membranes is less than the set differential pressure of the filter, the liquid supply amount of the concentrated liquid and / or the liquid supply amount of the waste liquid is increased, when the differential pressure between the filter membranes is within the range of the set differential pressure of the filter, the liquid supply amount of the concentrated liquid and / or the liquid supply amount of the waste liquid is maintained, and when the differential pressure between the filter membranes is greater than the set differential pressure of the filter, the liquid supply amount of the concentrated liquid and / or the liquid supply amount of the waste liquid is reduced.

[0041] The operating method of the raw liquid treatment device of the 20th invention is characterized in that, in the 12th and 19th inventions, the liquid supply section includes a concentrated liquid flow path liquid supply section arranged in the concentrated liquid flow path and a waste liquid flow path liquid supply section arranged in the waste liquid flow path, and when the differential pressure between the membranes of the concentrator is less than the set differential pressure of the concentrator, the liquid supply amount of the concentrated liquid in the concentrated liquid flow path is reduced and / or the liquid supply amount of the waste liquid in the waste liquid flow path is increased, and when the differential pressure between the membranes of the concentrator is within the range of the set differential pressure of the concentrator, the liquid supply amount of the concentrated liquid in the concentrated liquid flow path and / or the liquid supply amount of the waste liquid in the waste liquid flow path is maintained, and when the differential pressure between the membranes of the concentrator is greater than the set differential pressure of the concentrator, the liquid supply amount of the concentrated liquid in the concentrated liquid flow path is increased and / or the liquid supply amount of the waste liquid in the waste liquid flow path is reduced.

[0042] The operating method of the raw liquid treatment device of the 21st invention is characterized in that, in any one of the 12th to 20th inventions, a concentrated liquid container containing concentrated liquid is connected to the concentrated liquid flow path, and a flow path is provided for supplying the concentrated liquid in the concentrated liquid container from the concentrated liquid container to the filtrate supply port of the concentrator, so that the concentrated liquid is delivered in a manner that flows from the concentrated liquid container to the filtrate supply port of the concentrator.

[0043] The operating method of the raw liquid treatment apparatus of the 22nd invention is characterized in that, in any one of the 12th to 21st inventions, when recovering the filtrate and / or the concentrated liquid in the apparatus, gas or liquid is supplied to the filter.

[0044] The operating method of the raw liquid treatment device of the 23rd invention is characterized in that, in the 22nd invention, when the operation of recovering the concentrated liquid in the concentrator after recovering the filtrate in the filter is performed, if the differential pressure between the concentrator membranes of the concentrator is greater than the set differential pressure, the liquid supply from the filter to the concentrator is stopped.

[0045] The method for operating a raw liquid treatment apparatus according to a 24th invention is characterized in that, in the 23rd invention, after stopping the liquid supply from the filter to the concentrator, a gas is supplied to the filtrate supply flow path.

[0046] The operating method of the raw liquid treatment device of the 25th invention is characterized in that, in any one of the 12th invention to the 24th invention, the filter comprises a main body having a hollow space inside and a hollow fiber membrane arranged in the hollow space of the main body, and the filter is arranged in a manner of supplying raw liquid to the hollow fiber membrane or the hollow space of the main body, and when cleaning the hollow fiber membrane of the filter, the liquid in the hollow space or the hollow fiber membrane is discharged while air and / or cleaning liquid is supplied to the hollow space of the main body of the filter or the hollow fiber membrane, or While supplying air and / or cleaning liquid to the hollow space of the main body of the filter and the hollow fiber membranes, the liquid in the hollow space and the hollow fiber membranes is discharged, and then, cleaning liquid is supplied to the hollow space of the main body and / or the hollow fiber membrane in a manner that the cleaning liquid passes through the hollow fiber membranes and the hollow fiber membranes, or cleaning liquid is supplied to the hollow fiber membrane in a manner that the cleaning liquid passes through the hollow fiber membranes, or cleaning liquid is supplied to the hollow space of the main body in a manner that the cleaning liquid passes through the hollow space of the main body.

[0047] The operating method of the raw liquid treatment device of the 26th invention is characterized in that, in the 25th invention, when the filter discharges the liquid in the hollow space and / or the hollow fiber membrane, the air and / or the cleaning liquid is pressurized and supplied to the hollow space and / or the hollow fiber membrane, and / or the liquid in the hollow space and / or the hollow fiber membrane is discharged by negative pressure.

[0048] The operating method of the raw liquid treatment device of the 27th invention is characterized in that, in the 25th invention or the 26th invention, when the filter supplies air and / or cleaning liquid to the hollow space of the main body and / or the hollow fiber membrane, the air and / or cleaning liquid are pressurized and supplied to the hollow space and / or the hollow fiber membrane, and / or the hollow space and / or the hollow fiber membrane are set to negative pressure.

[0049] <Raw liquid treatment device (filter, concentrator cleaning)>

[0050] The raw liquid processing device of the 28th invention is a device for concentrating raw liquid to form concentrated liquid, and is characterized in that it comprises: a filter having a filtering component for filtering the raw liquid; a concentrator supplied with a filtrate filtered by the filter and concentrating the filtrate to form the concentrated liquid; a raw liquid supply unit for supplying the raw liquid to the filter; a liquid supply path for connecting the raw liquid supply unit with the raw liquid supply port of the filter; a filtrate supply path for connecting the filtrate discharge port of the filter with the filtrate supply port of the concentrator; a concentrated liquid path connected to the concentrated liquid discharge port of the concentrator; and a waste liquid path connected to the waste liquid discharge port. The discharge port discharges the waste liquid separated from the concentrated liquid in the concentrator; the liquid delivery unit delivers liquid to each flow path; the control unit controls the operation of the liquid delivery unit, the filter and / or the concentrator comprises a main body having a hollow space inside and a hollow fiber membrane arranged in the hollow space of the main body, and when cleaning the hollow fiber membrane in the filter and / or the concentrator, the control unit controls the operation of the liquid delivery unit so that the liquid passes through the hollow fiber membrane in a state in which the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the area to be cleaned in the hollow fiber membrane is filled.

[0051] The raw liquid treatment device of the 29th invention is characterized in that, in the 28th invention, when cleaning the hollow fiber membrane in the filter and / or the concentrator, the control unit controls the operation of the liquid delivery unit so that the liquid passes through the hollow fiber membrane after the hollow space of the main body and / or the hollow fiber membrane is filled with liquid to fill the area to be cleaned in the hollow fiber membrane.

[0052] The raw liquid treatment device of the 30th invention is characterized in that, in the 28th invention or the 29th invention, the filter is configured so that the axial direction of the hollow fiber membrane is in the up and down direction, and is provided with a port, and the port is arranged above the raw liquid supply port or the filtrate discharge port when cleaning the hollow fiber membrane in the filter, and can connect the hollow space of the main body with the outside, and the control unit controls the operation of the liquid delivery unit so that the liquid passes through the hollow fiber membrane of the filter in a state where the hollow space of the main body and / or the hollow fiber membrane is filled with liquid.

[0053] The raw liquid treatment device of the 31st invention is characterized in that, in the 28th, 29th or 30th invention, the concentrator is configured so that the axial direction of the hollow fiber membrane is in the up and down direction, and is provided with a port, and the port is arranged above the concentrated liquid discharge outlet or the waste liquid discharge outlet when cleaning the hollow fiber membrane in the concentrator, and can connect the hollow space of the main body with the outside, and the control unit controls the operation of the liquid delivery unit so that the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the hollow fiber membrane is completely or partially immersed in the liquid, so that the liquid passes through the hollow fiber membrane of the concentrator in this state.

[0054] The raw liquid treatment device of the 32nd invention is characterized in that, in the 28th invention or the 29th invention, when the filter and / or the concentrator is arranged in a manner that the axial direction of the hollow fiber membrane is oriented in a horizontal direction, the control unit controls the operation of the liquid delivery unit so that the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the hollow fiber membrane is entirely or partially immersed in the liquid, so that the liquid passes through the hollow fiber membrane in this state.

[0055] <Raw liquid treatment device>

[0056] The raw liquid processing device of the 33rd invention is a device for concentrating raw liquid to form concentrated liquid, and is characterized in that the device comprises: a filter having a filtering component for filtering the raw liquid; a concentrator supplied with a filtrate filtered by the filter and concentrating the filtrate to form the concentrated liquid; a raw liquid supply unit for supplying the raw liquid to the filter; a liquid supply path for connecting the raw liquid supply unit with the raw liquid supply port of the filter; and a filtrate supply path for connecting the filtrate discharge port of the filter with the filtrate supply port of the concentrator. communication; a concentrated liquid flow path connected to the concentrated liquid discharge port of the concentrator; a waste liquid flow path connected to the waste liquid discharge port, the waste liquid discharge port discharges the waste liquid separated from the concentrated liquid in the concentrator; a liquid delivery unit for delivering liquid to each flow path; a control unit for controlling the operation of the liquid delivery unit, the control unit controls the operation of the liquid delivery unit based on the filter membrane differential pressure of the filter and / or the concentrator membrane differential pressure of the concentrator, thereby adjusting the liquid delivery amount from the filter to the concentrator and / or the concentration ratio of the concentrated liquid.

[0057] The feature of the raw liquid treatment device of the 34th invention is that, in the 33rd invention, the liquid supply section comprises a liquid supply passage liquid supply section arranged in the liquid supply passage, and a concentrated liquid passage liquid supply section arranged in the concentrated liquid passage or a waste liquid passage liquid supply section arranged in the waste liquid passage, and the control section controls the operation of the liquid supply section in the following manner: when the differential pressure between the filter membranes is less than the set differential pressure of the filter, the liquid supply amount of the raw liquid to the filter is increased; when the differential pressure between the filter membranes is within the range of the set differential pressure of the filter, the liquid supply amount of the raw liquid to the filter is maintained; and when the differential pressure between the filter membranes is greater than the set differential pressure of the filter, the liquid supply amount of the raw liquid to the filter is reduced.

[0058] The raw liquid treatment device of the 35th invention is characterized in that, in the 33rd invention or the 34th invention, the liquid supply section has a liquid supply section arranged in the liquid supply channel, and a concentrated liquid channel liquid supply section arranged in the concentrated liquid channel or a waste liquid channel liquid supply section arranged in the waste liquid channel, and the control section controls the operation of the liquid supply section in the following manner: when the differential pressure between the concentrator membranes of the concentrator is less than the set differential pressure, the liquid supply amount from the filter to the concentrator is increased; when the differential pressure between the concentrator membranes of the concentrator is within the range of the set differential pressure, the liquid supply amount from the filter to the concentrator is maintained; when the differential pressure between the concentrator membranes of the concentrator is greater than the set differential pressure, the liquid supply amount from the filter to the concentrator is reduced.

[0059] The raw liquid treatment device of the 36th invention is characterized in that, in the 33rd, 34th or 35th invention, the liquid supply section has a liquid supply section arranged in the liquid supply section, and a concentrated liquid section arranged in the concentrated liquid section or a waste liquid section arranged in the waste liquid section, and the control section controls the operation of the liquid supply section in the following manner: when the differential pressure between the concentrator membranes of the concentrator is less than the set differential pressure, the flow rate of the concentrated liquid section is reduced or the flow rate of the waste liquid section is increased; when the differential pressure between the concentrator membranes of the concentrator is within the range of the set differential pressure, the flow rates of the concentrated liquid section and the waste liquid section are maintained; when the differential pressure between the concentrator membranes of the concentrator is greater than the set differential pressure, the flow rate of the concentrated liquid section is increased or the flow rate of the waste liquid section is reduced.

[0060] The raw liquid treatment device of the 37th invention is characterized in that, in the 33rd invention, the liquid supply section has a filtrate supply flow path liquid supply section arranged in the filtrate supply flow path, and a concentrated liquid flow path liquid supply section arranged in the concentrated liquid flow path or a waste liquid flow path liquid supply section arranged in the waste liquid flow path, and the control section controls the operation of the liquid supply section in the following manner: when the differential pressure between the filter membranes is smaller than the set differential pressure of the filter, the liquid supply amount of the filtrate to the concentrator is increased; when the differential pressure between the filter membranes is within the range of the set differential pressure of the filter, the liquid supply amount of the filtrate to the concentrator is maintained; when the differential pressure between the filter membranes is greater than the set differential pressure of the filter, the liquid supply amount of the filtrate to the concentrator is reduced.

[0061] The raw liquid treatment device of the 38th invention is characterized in that, in the 33rd invention or the 37th invention, the liquid supply section has a filtrate supply flow path liquid supply section arranged in the filtrate supply flow path, and a concentrated liquid flow path liquid supply section arranged in the concentrated liquid flow path or a waste liquid flow path liquid supply section arranged in the waste liquid flow path, and the control section controls the operation of the liquid supply section in the following manner: when the differential pressure between the membranes of the concentrator is less than the set differential pressure of the concentrator, the liquid supply amount of the concentrated liquid in the concentrated liquid flow path is reduced or the liquid supply amount of the waste liquid in the waste liquid flow path is increased; when the differential pressure between the membranes of the concentrator is within the range of the set differential pressure of the concentrator, the liquid supply amount of the concentrated liquid in the concentrated liquid flow path or the liquid supply amount of the waste liquid in the waste liquid flow path is maintained; when the differential pressure between the membranes of the concentrator is greater than the set differential pressure of the concentrator, the liquid supply amount of the concentrated liquid in the concentrated liquid flow path is increased or the liquid supply amount of the waste liquid in the waste liquid flow path is reduced.

[0062] The raw liquid treatment device of the 39th invention is characterized in that, in the 33rd, 37th or 38th invention, the liquid delivery section has a filtrate supply flow path liquid delivery section arranged in the filtrate supply flow path, and a concentrated liquid flow path liquid delivery section arranged in the concentrated liquid flow path or a waste liquid flow path liquid delivery section arranged in the waste liquid flow path, and the control section controls the operation of the liquid delivery section in the following manner: when the differential pressure between the membranes of the concentrator is less than the set differential pressure of the concentrator, the liquid delivery amount of the filtrate to the concentrator is increased; when the differential pressure between the membranes of the concentrator is within the range of the set differential pressure of the concentrator, the liquid delivery amount of the filtrate to the concentrator is maintained; when the differential pressure between the membranes of the concentrator is greater than the set differential pressure of the concentrator, the liquid delivery amount of the filtrate to the concentrator is reduced.

[0063] The raw liquid treatment device of the 40th invention is characterized in that, in the 33rd invention, the liquid supply section has a concentrated liquid flow path liquid supply section arranged in the concentrated liquid flow path and a waste liquid flow path liquid supply section arranged in the waste liquid flow path, and the control section controls the operation of the liquid supply section in the following manner: when the differential pressure between the filter membranes is less than the set differential pressure of the filter, the liquid supply amount of the concentrated liquid is increased and / or the liquid supply amount of the waste liquid is reduced; when the differential pressure between the filter membranes is within the range of the set differential pressure of the filter, the liquid supply amount of the concentrated liquid and the liquid supply amount of the waste liquid are maintained; when the differential pressure between the filter membranes is greater than the set differential pressure of the filter, the liquid supply amount of the concentrated liquid is reduced and / or the liquid supply amount of the waste liquid is increased.

[0064] The raw liquid treatment device of the 41st invention is characterized in that, in the 33rd invention or the 40th invention, the liquid supply section has a concentrated liquid flow path liquid supply section arranged in the concentrated liquid flow path and a waste liquid flow path liquid supply section arranged in the waste liquid flow path, and the control section controls the operation of the liquid supply section in the following manner: when the differential pressure between the membranes of the concentrator is less than the set differential pressure of the concentrator, the liquid supply amount of the concentrated liquid in the concentrated liquid flow path is reduced and / or the liquid supply amount of the waste liquid in the waste liquid flow path is increased; when the differential pressure between the membranes of the concentrator is within the range of the set differential pressure of the concentrator, the liquid supply amount of the concentrated liquid in the concentrated liquid flow path and / or the liquid supply amount of the waste liquid in the waste liquid flow path is maintained; when the differential pressure between the membranes of the concentrator is greater than the set differential pressure of the concentrator, the liquid supply amount of the concentrated liquid in the concentrated liquid flow path is increased and / or the liquid supply amount of the waste liquid in the waste liquid flow path is reduced.

[0065] The raw liquid processing device of the 42nd invention is characterized in that, in any one of the 33rd to 41st inventions, a concentrated liquid container containing concentrated liquid is connected to the concentrated liquid flow path, and a flow path is provided for supplying the concentrated liquid in the concentrated liquid container from the concentrated liquid container to the filtrate supply port of the concentrator, and the control unit controls the operation of the liquid delivery unit in such a manner that the concentrated liquid flows from the concentrated liquid container to the filtrate supply port of the concentrator.

[0066] The raw liquid treatment device according to the 43rd invention is characterized in that, in any one of the 33rd to 42nd inventions, the control unit supplies gas or liquid to the filter when performing an operation of recovering the filtrate in the filter.

[0067] The raw liquid treatment device of the 44th invention is characterized in that, in the 43rd invention, when the control unit is performing the operation of recovering the concentrated liquid in the concentrator after recovering the filtrate in the filter, if the differential pressure between the concentrator membranes of the concentrator is greater than the set differential pressure, the operation of the liquid supply unit is controlled to stop the liquid supply from the filter to the concentrator.

[0068] The raw liquid treatment device of the 45th invention is characterized in that, in the 44th invention, it is provided with a gas supply unit for supplying gas to the filtrate supply flow path, and after the control unit controls the operation of the liquid supply unit to stop the liquid supply from the filter to the concentrator, the operation of the gas supply unit is controlled to supply gas to the filtrate supply flow path.

[0069] The stock liquid processing device of the 46th invention is characterized in that, in any one of the 28th invention to the 45th invention, the liquid feeding part is a roller pump device having a roller with a tube arranged between the roller pump device and the support, and has a tube positioning component for holding the tube wound on the roller of the roller pump device, the tube positioning component having a pair of holding components arranged at intervals along the axial direction of the tube, and a connecting component for maintaining the pair of holding components in a state of being separated by a predetermined distance along the axial direction of the tube, a plurality of tube holding parts for holding a plurality of tubes are arranged in a row in each of the holding components, the plurality of tube holding parts are arranged so that when the plurality of tubes are arranged in a manner that the same tubes are held in corresponding tube holding parts in the pair of holding components, the plurality of tubes are parallel to each other, the connecting component is formed so that it can be bent between the pair of holding components in a direction intersecting with the direction in which the plurality of tube holding parts are arranged and the axial direction of the plurality of tubes held by the plurality of tube holding parts, and is arranged in a state in which the axial direction of the plurality of tubes held by the plurality of tube holding parts is parallel to the longitudinal direction of the connecting component when the connecting component is extended.

[0070] The raw liquid processing device of the 47th invention is characterized in that, in the 46th invention, the connecting part is arranged in the following manner: when the connecting part is stretched, the connecting part is located between adjacent tubes held by the multiple tube holding parts when viewed from the direction in which the multiple tube holding parts are arranged and from a direction intersecting with the axial direction of the multiple tubes held by the multiple tube holding parts.

[0071] The raw liquid processing device of the 48th invention is characterized in that, in the 46th invention or the 47th invention, the connecting part is arranged in the following manner: in the direction in which the multiple tube holding parts are arranged and in the direction intersecting the axial direction of the multiple tubes held by the multiple tube holding parts, it deviates from the central axis of the multiple tubes in the state of being held by the multiple tube holding parts.

[0072] The raw liquid processing device of the 49th invention is characterized in that, in the 46th, 47th or 48th invention, the pair of holding members are formed into an asymmetric shape with respect to a line dividing the holding members into two equal parts in the direction in which the plurality of tube holding portions are arranged.

[0073] The raw liquid processing device of the 50th invention is characterized in that, in the 46th, 47th, 48th or 49th invention, the control unit has a function of causing the roller to rotate forward or reverse when a tube is arranged between the bracket and the roller.

[0074] The raw liquid processing device of the 51st invention is characterized in that, in the 50th invention, the control unit has a function of sending an abnormality alarm when the rotation resistance reaches a predetermined value or more when the roller is rotated forward or reversely.

[0075] The raw liquid processing device of the 52nd invention is characterized in that, in the 50th invention or the 51st invention, the roller pump device has a pair of accommodating parts, and a pair of retaining parts of the tube positioning part are configured, and the pair of accommodating parts are arranged at positions clamping the surface including the rotating axis of the roller.

[0076] The feature of the raw liquid processing device of the 53rd invention is that, in any one of the 28th to 50th inventions, there is a tube holder for holding a tube, and the holder has a main body, a plurality of holding parts which are arranged on the first surface of the main body and can hold a plurality of tubes in a loadable and detachable manner, and a connecting part which connects the main body to other instruments, and the plurality of holding parts are arranged so that if a plurality of tubes are held by the plurality of holding parts, the axial directions of the plurality of tubes are parallel to each other and the plurality of tubes are arranged along the surface of the first surface of the main body.

[0077] The raw liquid processing device of the 54th invention is characterized in that, in the 53rd invention, the connecting portion has a snap-fitting component protruding toward the second surface side located on the opposite side of the first surface of the main body or protruding toward the first surface side, and the snap-fitting component has an opening formed at one end and a gap continuous with the opening.

[0078] Effects of the Invention

[0079] <How to clean the equipment>

[0080] According to the first to fifth aspects of the present invention, the effects of eliminating clogging of the hollow fiber membrane and removing substances deposited inside the hollow fiber membrane or the main body can be enhanced.

[0081] <Operation method (cleaning method) of the stock solution treatment device>

[0082] According to the sixth to eleventh aspects of the present invention, the effects of eliminating clogging of the hollow fiber membranes of the filter and the concentrator and removing substances deposited inside the hollow fiber membranes or the main body of the filter and the concentrator can be enhanced.

[0083] <Operation method of raw liquid treatment device>

[0084] According to the twelfth invention, since the liquid feeding section is controlled based on the differential pressure between the filter membranes and the differential pressure between the concentrator membranes, the capabilities of the filter and the concentrator can be effectively utilized.

[0085] <Positive Pressure / Positive Pressure>

[0086] According to the thirteenth invention, the time required to generate a concentrated solution from a raw solution can be shortened, and the concentration efficiency can be improved.

[0087] According to the fourteenth invention, it is possible to prevent the pressure in the concentrator from increasing and thus making it impossible to perform the operation or to prevent the concentrated liquid from being recovered in a dilute state.

[0088] According to the fifteenth invention, it is possible to prevent the pressure in the concentrator from increasing, making it impossible to perform the operation, or preventing the concentrated liquid with a relatively low concentration from being generated.

[0089] <Negative pressure / Positive pressure>

[0090] According to the sixteenth invention, the time required to generate a concentrated solution from a raw solution can be shortened, and the concentration efficiency can be improved.

[0091] According to the seventeenth invention, it is possible to prevent the pressure in the concentrator from increasing and thus making it impossible to perform the operation or to prevent the concentrated liquid from being recovered in a dilute state.

[0092] According to the eighteenth invention, it is possible to prevent the pressure in the concentrator from increasing, making it impossible to perform the operation, or generating a concentrated liquid with a relatively low concentration.

[0093] <Negative pressure / negative pressure>

[0094] According to the nineteenth invention, the time required to generate a concentrated solution from a raw solution can be shortened, and the concentration efficiency can be improved.

[0095] According to the twentieth invention, it is possible to prevent the pressure in the concentrator from increasing and thus making it impossible to perform the operation or to prevent the concentrated liquid from being recovered in a dilute state.

[0096] According to the 21st invention, the concentrated liquid can be efficiently re-concentrated.

[0097] According to the twenty-second aspect of the present invention, the filtrate in the filter and the filtrate supply flow path and the concentrated liquid in the concentrator and the concentrated liquid flow path can be efficiently recovered.

[0098] According to the twenty-third invention, it is possible to prevent the occurrence of a problem in which the pressure in the concentrator continues to rise when the concentrate in the concentrator and the concentrate flow path is recovered.

[0099] According to the twenty-fourth invention, it is possible to prevent the concentrated liquid from being missed in the concentrator or the concentrated liquid flow path.

[0100] <Cleaning>

[0101] According to the 25th to 27th inventions, the filtrate existing in the filter is prevented from being discharged by washing when the filter is washed, and the filtrate existing in the filter can be transported to the filter and concentrated to be recovered as a concentrated liquid. Therefore, the amount of effective components contained in the original liquid recovered in the concentrated liquid can be increased.

[0102] <Raw liquid treatment device (filter, concentrator cleaning)>

[0103] According to the 29th to 32nd inventions, the effects of eliminating clogging of the hollow fiber membrane and removing substances deposited inside the hollow fiber membrane or the main body can be enhanced.

[0104] <Raw liquid treatment device>

[0105] According to the 33rd invention, since the liquid delivery section is controlled based on the filter inter-membrane pressure difference and the concentrator inter-membrane pressure difference, the capabilities of the filter and the concentrator can be effectively utilized, thereby shortening the time for generating the concentrated liquid from the raw liquid and improving the concentration efficiency.

[0106] <Positive Pressure / Positive Pressure>

[0107] According to the 34th invention, the time required to generate a concentrated solution from a raw solution can be shortened, and the concentration efficiency can be improved.

[0108] According to the thirty-fifth invention, it is possible to prevent the pressure in the concentrator from increasing and thus making it impossible to perform operations or to prevent the concentrated liquid from being recovered in a dilute state.

[0109] According to the thirty-sixth invention, it is possible to prevent the pressure in the concentrator from increasing, making it impossible to perform operations, or preventing the generation of a concentrated liquid with a relatively low concentration.

[0110] <Negative pressure / Positive pressure>

[0111] According to the 37th invention, the time required to generate a concentrated solution from a raw solution can be shortened, and the concentration efficiency can be improved.

[0112] According to the thirty-eighth invention, it is possible to prevent the pressure in the concentrator from increasing and thus making it impossible to perform operations or to prevent the concentrated liquid from being recovered in a dilute state.

[0113] According to the thirty-ninth invention, it is possible to prevent the pressure in the concentrator from increasing, making it impossible to perform operations, or preventing the generation of a concentrated liquid with a relatively low concentration.

[0114] <Negative pressure / negative pressure>

[0115] According to the 40th invention, the time required to generate a concentrated solution from a raw solution can be shortened, and the concentration efficiency can be improved.

[0116] According to the 41st invention, it is possible to prevent the pressure in the concentrator from increasing and thus making it impossible to perform operations or to prevent the concentrated liquid from being recovered in a dilute state.

[0117] According to the 42nd invention, the concentrated liquid can be efficiently re-concentrated.

[0118] According to the 43rd invention, the filtrate in the filter and the filtrate supply flow path and the concentrated liquid in the concentrator and the concentrated liquid flow path can be efficiently recovered.

[0119] According to the 44th invention, it is possible to prevent the occurrence of a problem in which the pressure in the concentrator continues to rise when the concentrate in the concentrator and the concentrate flow path is recovered.

[0120] According to the 45th invention, it is possible to prevent the recovery omission of the concentrated liquid in the concentrator or the concentrated liquid flow path.

[0121] <Tube positioning parts>

[0122] According to the 46th invention, the tube for the roller pump can be easily and reliably installed.

[0123] According to the 47th and 48th inventions, even if a plurality of tubes are arranged in a vertical arrangement, it is possible to prevent the upper tube from contacting the lower tube.

[0124] According to the 49th invention, it is possible to prevent operational errors when setting the tube on the roller pump.

[0125] <Roller Pump>

[0126] According to the 50th invention, even if the arrangement of the pipe is slightly deviated from the appropriate position, the pipe can be moved to the appropriate position. Thus, since the arrangement of the pipe does not need to be redone, the operation time can be shortened.

[0127] According to the fifty-first invention, it is possible to prevent damage to the device due to the inappropriate configuration of the pipe, and the operator can quickly notice the abnormality.

[0128] According to the fifty-second invention, it is possible to prevent operational errors when installing the tube in the roller pump.

[0129] <Pipe support>

[0130] According to the fifty-third invention, when a plurality of pipes are set in the device, the operator's work becomes easier.

[0131] According to the fifty-fourth invention, it is possible to achieve a state in which waste liquid can be easily discharged from a plurality of pipes into a bucket or the like. BRIEF DESCRIPTION OF THE DRAWINGS

[0132] Figure 1It is a circuit diagram of the raw liquid treatment device 1 according to the first embodiment and is a schematic explanatory diagram of the filtration and concentration operation.

[0133] Figure 2 It is a circuit diagram of the raw liquid processing apparatus 1 of the first embodiment and is a schematic explanatory diagram of the preparation and cleaning work.

[0134] Figure 3 It is a circuit diagram of the raw liquid treatment device 1 according to the first embodiment and is a schematic explanatory diagram of the re-concentration operation.

[0135] Figure 4 This is a circuit diagram of the raw liquid treatment apparatus 1 according to the first embodiment, and shows an example in which a waste liquid pipe liquid feeding section 5 p is provided in the waste liquid pipe 5 .

[0136] Figure 5 It is a schematic explanatory diagram of the filter 10 .

[0137] Figure 6 It is a circuit diagram of the raw liquid processing apparatus 1B according to the second embodiment and is a schematic explanatory diagram of the preparation and cleaning work.

[0138] Figure 7 It is a circuit diagram of the raw liquid treatment apparatus 1B according to the second embodiment and is a schematic explanatory diagram of the filtration and concentration operation.

[0139] Figure 8 It is a circuit diagram of the raw liquid treatment apparatus 1B according to the second embodiment and is a schematic explanatory diagram of the re-concentration operation.

[0140] Fig. 9 This is a circuit diagram of the raw liquid treatment apparatus 1B according to the second embodiment, and shows an example in which a waste liquid pipe liquid feeding section 5 p is provided in the waste liquid pipe 5 .

[0141] Fig.10 It is a circuit diagram of the raw liquid processing apparatus 1C according to the third embodiment and is a schematic explanatory diagram of the preparation and cleaning work.

[0142] Fig.11 It is a circuit diagram of a raw liquid treatment apparatus 1C according to the third embodiment and is a schematic explanatory diagram of a filtration and concentration operation.

[0143] Fig.12 It is a circuit diagram of a raw liquid treatment apparatus 1C according to the third embodiment and is a schematic explanatory diagram of a re-concentration operation.

[0144] Fig.13 It is a schematic explanatory diagram of the raw liquid processing apparatus 1 according to the first embodiment, and is a schematic explanatory diagram of a state in which the cover portions 112 of the roller pumps 110 and 120 are closed.

[0145] Fig.14It is a schematic explanatory diagram of the raw liquid processing apparatus 1 according to the first embodiment, and is a schematic explanatory diagram of a state in which the lids 112 of the roller pumps 110 and 120 are opened.

[0146] Fig.15 is a schematic diagram of the roller pump 110, and Fig.15 (A) is a schematic perspective view of a state where the cover portion 112 is opened, and (B) is a schematic side view of a state where the cover portion 112 is opened.

[0147] Fig.16 1 is a schematic diagram of the tube positioning member 160 in a state where the tube T is installed, and Fig.16 (A) is a schematic three-dimensional view of the bent state, (B) is a schematic top view of the bent state, and (C) is a schematic rear view of the bent state.

[0148] Fig.17 (A) is a schematic explanatory diagram of the tube positioning member 160 after being decomposed, and (B) is a schematic explanatory diagram of the tube positioning member 160 in a state where the tube T is mounted.

[0149] Fig.18 (A) is a schematic perspective view of the pipe holder 150, and (B) is a schematic explanatory view of a state where the pipe holder 150 is installed on a barrel.

[0150] Fig.19 It is a schematic explanatory diagram of the raw liquid processing device 1 according to the first embodiment.

[0151] Fig. 20 It is a schematic explanatory diagram of the filter 10 during the cleaning operation.

[0152] Fig.21 It is a circuit diagram of the raw liquid processing apparatus 1 according to the first embodiment and is a schematic explanatory diagram of the cleaning operation.

[0153] Fig. 22 It is a circuit diagram of the raw liquid processing apparatus 1B according to the second embodiment and is a schematic explanatory diagram of the cleaning operation.

[0154] Fig.23 It is a circuit diagram of the raw liquid processing apparatus 1C according to the third embodiment and is a schematic explanatory diagram of the cleaning operation.

[0155] Fig.24 (A) is a diagram showing the differential pressure between filter membranes when the flow rate of the raw liquid supplied to the filter 10 is adjusted, and (B) is a diagram showing the flow rate change in the liquid supply pipe 2 when the flow rate of the raw liquid supplied to the filter 10 is adjusted. DETAILED DESCRIPTION

[0156] The stock solution treatment device of the present invention is a device for obtaining a treated solution, wherein the treated solution is a treated solution that can be administered to a patient by intravenous infusion or intraperitoneal administration after filtering and concentrating a stock solution such as pleural effusion or peritoneal effusion.

[0157] The stock liquid to be processed by the stock liquid processing device of the present invention is not particularly limited, and examples thereof include pleural effusion, plasma, blood, etc. Pleural effusion refers to pleural effusion or peritoneal effusion accumulated in the pleural cavity or abdominal cavity due to cancerous pleural peritonitis, liver cirrhosis, etc. The pleural effusion contains plasma components (proteins, hormones, sugars, lipids, electrolytes, vitamins, bilirubin, amino acids, etc.), hemoglobin, cancer cells, macrophages, tissue cells, white blood cells, red blood cells, platelets, bacteria, etc. that have seeped from blood vessels or internal organs. In the stock liquid processing device of the present invention, solid components such as cancer cells, macrophages, tissue cells, white blood cells, red blood cells, platelets, bacteria, etc. can be removed from the pleural effusion, thereby generating a concentrated solution containing water and useful components contained in the pleural effusion.

[0158] Examples of plasma include waste plasma from plasma exchange therapy, and examples of blood include blood recovered during surgery. That is, by purifying waste plasma, blood recovered during surgery, etc. using the stock solution processing device of the present invention, reusable regenerated plasma can be produced. In addition, in the stock solution processing device of the present invention, when treating waste plasma from plasma exchange therapy, a plasma component separator can be used instead of a filter, and when treating blood recovered during surgery, a plasma separator can be used instead of a filter.

[0159] In addition, the filter component of the filter used in the raw liquid treatment device of the present invention is not particularly limited. In addition, there are also cases where the same filter component is used for the concentration of the filtrate in the concentrator. As long as the filter component used for such filtration or concentration allows the plasma, water and the above-mentioned useful components contained in the pleural and abdominal effusion to pass through, and prevents cell components (i.e., solid components) such as cancer cells, macrophages, tissue cells, white blood cells, red blood cells, platelets, bacteria, etc. from passing through, and the components that make the gas impermeable can be used, and its raw materials, size, and shape are not particularly limited. For example, the shape of the filter component can use a hollow fiber membrane, a flat membrane, a laminated membrane, etc. In addition, the filter component can use a component formed by a raw material that performs the function of making the gas impermeable when wetted by a liquid. Of course, a component formed by a raw material that also performs the function of making the gas impermeable when not wetted by a liquid can also be used. In addition, in this specification, the gas that does not pass through the filter component refers to an inert gas such as nitrogen, air, oxygen, etc., which indicates a gas generally used for leakage inspection, etc.

[0160] As an example, a hollow fiber membrane used in a peritoneal fluid filter for CART, a plasma separator for plasma exchange, a plasma component separator for plasma exchange, etc. can be used in the filter and concentrator of the stock solution processing device of the present invention.

[0161] <Dry Liquid Treatment Device 1 of First Embodiment>

[0162] based on Figures 13 to 19 A raw liquid processing apparatus 1 according to the first embodiment will be described.

[0163] It is needless to say that the appearance of the liquid treatment apparatus 1 of the first embodiment and the arrangement, relative size, and number of the various instruments are not limited to the above. Figures 13 to 19 The described contents can be appropriately changed according to the environment and purpose in which the raw liquid treatment apparatus 1 of the first embodiment is used.

[0164] like Fig.13 , Fig.14 , Fig.19 As shown, the raw liquid processing device 1 of the first embodiment includes: a main body 100, a pair of roller pumps 110, 120 arranged in the main body 100, a filter holding part 101 for holding the filter 10, a concentrator holding part 102 for holding the concentrator 20, and a pair of hanging parts 103, 103 on which the tube bracket 150 or each bag B is hung.

[0165] Furthermore, in the raw liquid processing apparatus 1 of the first embodiment, when the raw liquid is processed, each bag B is hung on the pair of hanging parts 103, 103, and the filter 10 and the concentrator 20 are held by the filter holding part 101 and the concentrator holding part 102. Furthermore, each bag B, the filter 10, and the concentrator 20 are appropriately connected by a plurality of tubes T, and an appropriate tube T is provided on the pair of roller pumps 110, 120. In this state, if the pair of roller pumps 110, 120 is operated, the raw liquid in the raw liquid bag UB can be filtered and concentrated to obtain a concentrated liquid.

[0166] In addition, if the operating state of a pair of roller pumps 110 and 120 is changed, the bags B connected to the tubes T are changed, the tube T for liquid flow is changed, etc., not only can a concentrated liquid be obtained, but also the concentrated liquid can be re-concentrated, the filter 10 and the concentrator 20 can be cleaned, and the liquid present in the filter 10 and the concentrator 20 can be recovered.

[0167] <Description of Each Configuration of the Raw Liquid Treatment Device 1 of the First Embodiment>

[0168] Hereinafter, each device part of the raw liquid processing device 1 of the first embodiment will be described.

[0169] <Main body 100>

[0170] like Fig.13 , Fig.14 , Fig.19 As shown, the main body 100 has a control unit 106 in its central portion. The control unit 106 has a function of controlling the operation of a pair of roller pumps 110, 120 and the entire device. In addition, the control unit 106 is provided with a panel unit 106p that takes into account both an operation panel for operating the device and a display panel that displays various displays. That is, the operator can instruct the treatment to be performed on the raw liquid treatment device 1 of the first embodiment by giving instructions from the panel unit 106p to the control unit 106. In addition, the operator can understand the status of the raw liquid treatment device 1 of the first embodiment by confirming the numerical value or warning displayed on the panel unit 106p according to the instruction from the control unit 106.

[0171] Furthermore, the control unit 106 may include buttons for performing various operations in addition to the panel unit 106p.

[0172] <Roller Pumps 110, 120>

[0173] like Fig.13 , Fig.14 , Fig.19 As shown, a pair of roller pumps 110 and 120 are provided on both sides of the control unit 106 of the main body 100. Since the pair of roller pumps 110 and 120 have substantially the same structure, the roller pump 110 will be described below.

[0174] In addition, Fig.15 In order to facilitate understanding of the roller pump 110, the state in which the portion that functions as the roller pump 110 is removed from the main body 100 is shown. Fig.15 The roller pump 110 will be described.

[0175] like Fig.15 As shown, the roller pump 110 includes a frame 111 and a cover 112 that is openably and closably mounted on the frame 111. Specifically, when the cover 112 is opened, a roller portion 115 described later is exposed, and when the cover 112 is closed, the cover 112 is provided so that the roller portion 115 can be covered by the cover 112. In addition, when the cover 112 is closed, the cover 112 is provided so that a space for accommodating the roller portion 115 is formed between the inner surface of the cover 112 and the upper surface of the frame 111.

[0176] A roller portion 115 having two rollers 116 is provided on the upper surface of the frame 111 (see Fig.16). The roller part 115 has two rollers 116 mounted on a shaft 117, and the shaft 117 is rotated by a driving source 114 such as a motor. That is, when the shaft 117 is rotated by the driving source 114, the two rollers 116 rotate. In addition, the number of rollers 116 provided in the roller part 115 is not limited to two, and may be one, or may be three or more. It is sufficient to provide the rollers 116 in the number suitable for the processing operation.

[0177] In addition, a bracket 113 is provided on the upper surface of the frame 111 at a position facing the roller portion 115. A recessed surface 113a is provided on the surface of the bracket 113 facing the two rollers 116 of the roller portion 115, and the tube T is sandwiched between the bracket 113 and the two rollers 116. The bracket 113 can move closer to and away from the roller portion 115 in conjunction with the opening and closing of the cover 112 by means of a slider mechanism or the like. Specifically, when the cover 112 is opened, the bracket 113 moves away from the roller portion 115 so that the space between the recessed surface 113a of the bracket 113 and the two rollers 116 becomes wider than the diameter of the tube T. When the cover 112 is closed, the bracket 113 moves closer to the roller portion 115 so that the gap between the recessed surface 113a of the bracket 113 and the two rollers 116 becomes narrower than the diameter of the tube T. That is, when the cover 112 is opened, the tube T can be placed or removed between the cover 112 and the roller 115 , and when the cover 112 is closed, the tube T can be sandwiched between the recessed surface 113 a of the bracket 113 and the two rollers 116 .

[0178] Therefore, by opening the cover 112, placing the tube T between the roller 115 and the recessed surface 113a of the holder 113, and closing the cover 112, the tube T can be clamped by the roller 115 and the holder 113. Furthermore, by operating the drive source 114 in a state where the tube T is clamped by the roller 115 and the holder 113, the liquid in the tube T can be fed.

[0179] In addition, the roller 116 only needs to have the same structure as the roller used in a general roller pump. Fig.16 As shown in (C), the roller 116 can use a roller in which a plurality of rollers 116b (for example, three rollers 116b) are provided between a pair of cover plates 116a. When such rollers 116 are used, the tube T can be sandwiched between the plurality of rollers 116b and the recessed surface 113a of the bracket 113, and when the roller 116 rotates, the roller 116b moves in a manner to manipulate the tube T, thereby being able to deliver the liquid in the tube T.

[0180] In addition, when the cover 112 is closed, the size of the gap formed between the recessed surface 113a of the bracket 113 and the two rollers 116 can be an appropriate gap as long as it matches the tube T arranged on the rollers 116. The appropriate gap refers to a gap that can clamp the tube T so that the liquid does not flow when the rollers 116 are not rotating, and the rotation resistance of the rollers 116 does not increase too much when the rollers 116 rotate.

[0181] Furthermore, when a plurality of tubes T are arranged on the roller 116 and the diameters of the arranged tubes T are different, the gap may be changed according to the position where each tube T is arranged. For example, by providing a height difference on the recessed surface 113a of the bracket 113 so that the distance from the recessed surface 113a of the bracket 113 to the roller 116 is different, the gap can be changed according to the position where each tube T is arranged (that is, the roller 116 arranged). On the other hand, when a plurality of rollers 116 are provided and the diameters of the tubes T arranged on each roller 116 are different, the gap can be changed to match the tube T by changing the diameter of the roller 116.

[0182] <Control of Roller Pump 110>

[0183] Here, when the tube T is arranged between the roller portion 115 and the recessed surface 113a of the bracket 113, the tube T may not be arranged at an appropriate position. When the driving source 114 is operated in such a state, the tube T may interfere with the roller 116 other than the roller portion 115. When the tube T interferes with the roller 116 other than the roller portion 115, liquid delivery may not be performed, or the tube T or the roller 116 may be damaged.

[0184] Therefore, the control unit 106 may have the following function: when it is detected that the cover 112 is closed, the drive source 114 is operated to rotate the roller 116 forward or reversely. If the roller 116 is rotated forward or reversely (for example, about ±180 to 360 degrees), the tube T can be moved to the appropriate position even if the arrangement of the tube T is slightly deviated from the appropriate position. As a result, the arrangement of the tube T does not need to be readjusted, and thus the operation time can be shortened.

[0185] Furthermore, even if the roller 116 is rotated forward or reversely, the tube T may not be arranged at an appropriate position. Therefore, it is desirable that the control unit 106 has a safety function of disabling the operation of the drive source 114 if it is detected that the tube T cannot be arranged at an appropriate position, and an alarm function of notifying the operator that the tube T is not arranged properly. This can prevent damage to the device due to the improper arrangement of the tube T, and the operator can quickly notice the abnormality of the arrangement of the tube T.

[0186] For example, the alarm function may include a function in which, when the control unit 106 detects that the tube T is not disposed at an appropriate position, the control unit 106 causes the panel unit 106 p to display an abnormality alarm or to sound an abnormality alarm.

[0187] In addition, as a method of detecting that the tube T is not arranged at an appropriate position, for example, a method of detecting the driving force of the driving unit 114 can be adopted. In this case, when the driving force of the driving unit 114 reaches a certain value or more, the control unit 106 can be made to determine that the arrangement of the tube T is abnormal. If the driving unit 114 is a motor, when the rotation resistance applied to the main shaft reaches a predetermined value or more, the control unit 106 can be made to determine that the arrangement of the tube T is abnormal. The rotation resistance applied to the main shaft can be determined by, for example, detecting the current value supplied to the motor.

[0188] <Tube Positioning Component 160>

[0189] As a method of arranging the tube T at an appropriate position, the following tube positioning member 160 can be used. If the following tube positioning member 160 is used, when the tube T is wound around the roller 116, it becomes easy to make the tube T and the roller 116 closely contact, and it becomes easy to appropriately wind two tubes T around the two rollers 116, respectively.

[0190] Next, the structure of the tube positioning member 160 will be described.

[0191] like Fig.16 as well as Fig.17 As shown, the tube positioning member 160 includes a pair of holding members 161 , 161 and a connecting member 165 .

[0192] <A Pair of Holding Members 161, 161>

[0193] like Fig.16 as well as Fig.17 As shown, a pair of holding members 161, 161 is a member for holding two tubes T, and is a member arranged in a state of being spaced apart from each other (in a state of being separated by a distance) along the axial direction of the two tubes T. The pair of holding members 161, 161 has the same structure, and is formed by combining a base member 162 and a guide member 163.

[0194] The base member 162 includes a base portion 162b which is a strip-shaped plate-shaped member. The base member 162 has a structure for holding the tube T in such a manner that the long axis direction of the base portion 162b is orthogonal to the axial direction of the tube T. Specifically, a tube arrangement portion 162c extending from the base portion 162b is provided on the side of the base member 162 in the short axis direction. The tube arrangement portion 162c is provided with a pair of outer holding portions d, d erected from the surface of the tube arrangement portion 162c and a pair of inner holding portions c, c located between the pair of outer holding portions d, d and the base portion 162b. The pair of inner holding portions c, c are arranged on the inner side of the long axis direction of the base portion 162b closer to the pair of outer holding portions d, d. In addition, the pair of inner holding portions c, c have an erected portion erected from the surface of the tube arrangement portion 162c and a bent portion bent toward the outer side of the long axis direction of the base portion 162b relative to the erected portion. Furthermore, the pair of inner holding portions c, c are formed so that the distance between the outer surface of the upright portion and the inner surface of the pair of outer holding portions d, d in the long-axis direction of the base portion 162b is substantially the same as the diameter of the tube T. Furthermore, the pair of inner holding portions c, c are formed so that the distance between the lower surface of the curved portion and the surface of the base portion 162b is also substantially the same as the diameter of the tube T.

[0195] Thus, when observing the base portion 162b from the short axis direction, two holes (hereinafter referred to as imaginary holes) are formed by the inner surfaces of a pair of outer retaining portions d, d, the outer surfaces of the upright portions of a pair of inner retaining portions c, c, the lower surface of the curved portion, and the surface of the base portion 162b.

[0196] On the other hand, the guide member 163 is a member arranged so as to overlap with the surface of the base portion 162b of the base member 162. In the guide member 163, a pair of grooves 163g, 163g for accommodating the tube T are provided on the surface located on the surface side of the base portion 162b when overlapping with the surface of the base portion 162b. The pair of grooves 163g, 163g are provided so as to be parallel to each other in their axial directions. And, the pair of grooves 163g, 163g are formed so that when the guide member 163 is overlapped with the surface of the base portion 162b, the pair of grooves 163g, 163g overlap with (preferably coincide with) two imaginary holes when viewed from the short axis direction of the base portion 162b.

[0197] Therefore, if two tubes T are respectively arranged in the two imaginary holes of the base member 162, the two tubes T can be arranged in parallel with each other on the base member 162. In this state, if the guide member 163 is overlapped on the surface of the base portion 162b, the two tubes T can be arranged in the pair of grooves 163g, 163g, and the two tubes T can be held by the holding member 161 so that the two tubes T do not fall off.

[0198] The tube arrangement portion 162c of the base member 162 and the pair of grooves 163g, 163g of the guide member 163 correspond to the "plural tube holding portions" mentioned in the claims. In addition, the long axis direction of the base portion 162b corresponds to the "direction in which the plurality of tube holding portions are arranged" mentioned in the claims. Furthermore, the short axis direction of the base portion 162b corresponds to the "axial direction of the plurality of tubes held by the plurality of tube holding portions" mentioned in the claims.

[0199] <Connecting member 165>

[0200] like Fig.16 as well as Fig.17 As shown, the connecting member 165 is a member connecting the pair of tube holding parts 161, 161. More specifically, in order to maintain the pair of tube holding parts 161, 161 in a state separated by a predetermined distance in the axial direction of the tube T, the connecting member 165 is provided between the pair of tube holding parts 161, 161.

[0201] The connecting member 165 has a connecting structure connected to the pair of tube holding parts 161, 161 at both ends thereof, and can be connected to the guide member 163 of the tube holding part 161 in a detachable manner. Specifically, the connecting member 165 is provided in a manner that the end of the connecting member 165 is connected to a portion between the pair of grooves 163g, 163g in the guide member 163. That is, in a state where the connecting member 165 is extended, the connecting member 165 is connected to the guide member 163 in a manner that the connecting member 165 is located between adjacent tubes T held in the tube holding part 161 when viewed from a direction intersecting the major axis direction and the minor axis direction of the base part 162b.

[0202] Then, in the state where the connecting member 165 is extended, the connecting member 165 is connected to the guide member 163 so as to be located at a position on the opposite side of the base portion 162 b with respect to the central axis of the tube T held by the tube holding portion 161 .

[0203] Furthermore, the connecting member 165 has a structure capable of bending between the pair of tube holding portions 161, 161 in a state where both ends are connected to the pair of tube holding portions 161, 161. More specifically, the connecting member 165 has a structure capable of bending between the pair of tube holding portions 161, 161 in a direction intersecting the major axis direction and the minor axis direction of the base portion 162b.

[0204] For example, the connecting member 165 is formed of a plate-like member made of plastic. The two ends of the connecting member 165 are connected to the guide members 163 of the pair of tube holding parts 161, 161 so that the width direction of the connecting member 165 is parallel to the long axis direction of the base part 162b. Thus, the connecting member 165 can be bent between the pair of tube holding parts 161, 161 in a direction intersecting the long axis direction and the short axis direction of the base part 162b ( Fig.16 ).

[0205] If the tube positioning member 160 is mounted on two tubes T, when the two tubes T are arranged in the roller pump 110, the following advantages can be obtained.

[0206] First, when the tube T is wound around the two rollers 116, 116 of the roller portion 115 of the roller pump 110, the stoppers T1, T2 are preliminarily provided so as to be arranged at positions separated by an appropriate length (see Fig.16 , Fig.17 On the other hand, a pair of tube holding portions 161, 161 are disposed between the stop members T1, T2 so that the outer surfaces of the pair of tube holding portions 161, 161 are in contact with the stop members T1, T2, respectively. Furthermore, in a state where the tube T is stretched and the outer surfaces of the pair of tube holding portions 161, 161 are in contact with the stop members T1, T2, respectively (hereinafter referred to as a properly disposed state), the connecting member 165 is disposed between the pair of tube holding portions 161, 161 so that it is in a stretched state (refer to Fig.17 (B)).

[0207] On the other hand, a pair of accommodating parts for accommodating a pair of tube holding parts 161, 161 is pre-set in the roller pump 110. Specifically, a pair of accommodating parts for accommodating a pair of tube holding parts 161, 161 is pre-set at positions sandwiching the surface of the rotating shaft 117 including the roller part 115. The pair of accommodating parts are pre-set so that when the pair of tube holding parts 161, 161 are respectively accommodated in the pair of accommodating parts, the tube T is wound around the two rollers 116, 116 of the roller part 115 in an appropriate state.

[0208] Thus, only by arranging the pair of tube holding portions 161, 161 in the pair of accommodating portions, the two tubes T can be appropriately wound around the two rollers 116, 116 of the roller portion 115 (see Fig.15 ).

[0209] The connecting member 165 is connected to the guide member 163 so that the connecting member 165 is located on the opposite side of the base portion 162b from the central axis of the tube T held by the tube holding portion 161. Thus, when the tube T is wound around the roller 116 of the roller portion 115 so that the guide member 163 is located on the roller 116 side, the connecting member 165 is located between the two tubes T with the center portion between the two ends being slightly bent (see FIG. Fig.16 (A), (B)). Thus, even if the two tubes T are arranged in a vertical direction, the connecting member 165 can prevent the upper tube T from contacting the lower tube T.

[0210] In addition, the connection member 165 does not necessarily need to be located on the opposite side of the base portion 162b from the central axis of the tube T. However, if this structure is adopted, the above-mentioned effects can be obtained.

[0211] In addition, the tube holding portion 161 may be asymmetrical with respect to the middle of the long axis direction of the base portion 162b. In other words, the tube holding portion 161 may be formed asymmetrically with respect to the middle of the two tubes T held in the tube holding portion 161 in the long axis direction of the base portion 162b. For example, Fig.17 As shown, the lengths of the portions of the guide member 163 located outside the pair of grooves 163g, 163g may be different. In this way, when the pair of tube holders 161, 161 are arranged in the pair of accommodating portions, it is possible to prevent the pair of tube holders 161, 161 from being placed incorrectly. That is, even if the pair of tube holders 161, 161 are arranged in the pair of accommodating portions from the wrong direction, the pair of tube holders 161, 161 can be set to a state where they cannot be accommodated in the pair of accommodating portions. Thus, it is possible to prevent operational errors when setting the tube T in the roller pump 110. For example, when the tube T is set in the roller pump, it is possible to prevent the tube T from being twisted or the two tubes from being set on opposite rollers 116.

[0212] In addition, when there are a plurality of roller pumps, the tube holding portion 161 may be changed in size or shape according to the roller pump to be installed. This can prevent the roller pump of the tube from being mistakenly installed.

[0213] Furthermore, a function may be provided to prevent the roller pump device from operating when the tube holder 161 is not properly provided in the pair of housings. In this case, even if the roller 116 rotates erroneously when the tube T is not properly provided, damage to the tube T and the roller 116 can be prevented. For example, if a button-type sensor that is pressed when the tube holder 161 is properly provided in the pair of housings, the above function can be achieved.

[0214] In the above example, the case where the tube positioning member 160 holds two tubes T is described. However, the tube positioning member 160 may hold three or more tubes T, and is not particularly limited. In addition, when the tube positioning member 160 holds three or more tubes T, it is desirable to provide the connecting member 165 between the adjacent tubes T, respectively.

[0215] In addition, the structure of the holding component 161 and the multiple tube holding parts is not limited to the above-mentioned structure. The holding component 161 and the multiple tube holding parts only need to be able to hold multiple tubes in parallel and in a row. For example, it is also possible to form multiple tube holding parts by only forming through holes in a row on a plate-shaped holding component. The row mentioned here also refers to the following situations: when multiple tubes are arranged in multiple tube holding parts, the central axes of the multiple tubes are roughly arranged on the same plane; when the tube T is observed from the axial direction of the tube T held in the multiple tube holding parts, the position of the central axis of the tube T deviates in the normal direction of the surface of the base component 162. For example, when the tube T is observed from the axial direction of the tube T held in the multiple tube holding parts, the position of the central axis of the tube T is arranged in a staggered manner, which is also included in the above-mentioned state where multiple tubes are held in a row.

[0216] <Filter Holding Unit 101 and Concentrator Holding Unit 102>

[0217] like Fig.13 , Fig.14 as well as Fig.19 As shown in FIG. 1 , a filter holding portion 101 and a concentrator holding portion 102 are respectively provided on the outer sides of a pair of roller pumps 110 and 120. Fig.13 as well as Fig.14 As shown, the roller pump 110 provided on the left side of the control unit 106 includes a filter holding unit 101 , and the roller pump 120 provided on the right side of the control unit 106 includes a concentrator holding unit 102 .

[0218] The filter holding portion 101 and the concentrator holding portion 102 are provided with clamping portions 101 c and 102 c on the surfaces thereof, and the filter 10 and the concentrator 20 can be detachably held by the clamping portions 101 c and 102 c.

[0219] Furthermore, the base ends of the filter holder 101 and the concentrator holder 102 are swingably connected to the frames of the pair of roller pumps 110 and 120. Specifically, when the filter holder 101 and the concentrator holder 102 are swung outward, the filter holder 101 and the concentrator holder 102 are connected to the frames of the pair of roller pumps 110 and 120 so that the clamping parts 101c and 102c are exposed. Conversely, when the filter holder 101 and the concentrator holder 102 are swung inward, the filter holder 101 and the concentrator holder 102 are connected to the frames of the pair of roller pumps 110 and 120 so that the clamping parts 101c and 102c are opposed to the pair of rollers 116 and 116 of the pair of roller pumps 110 and 120. That is, when the operation of treating the raw liquid is not performed, the filter holder 101 and the concentrator holder 102 can be accommodated in the roller pumps 110 and 120. In addition, the filter holder 101 and the concentrator holder 102 do not necessarily need to be swingably connected to the frames of the pair of roller pumps 110 and 120, but are always exposed to the outside of the roller pumps 110 and 120. However, if the above-mentioned structure is adopted, the advantage of being able to compactly accommodate the raw liquid treatment device 1 of the first embodiment when the raw liquid treatment device 1 of the first embodiment is not used can be obtained.

[0220] In addition, Fig.13 , Fig.14 as well as Fig.19 , the following situation is shown: the filter holding part 101 and the concentrator holding part 102 are arranged in the axial direction of the filter 10 and the concentrator 20 (for example, Figure 5 As shown, in the case where the hollow fiber membrane 16 is provided inside, the filter 10 and the concentrator 20 are held in a state where the axial direction of the hollow fiber membrane 16 is oriented in the up-down direction. However, the filter holding portion 101 and the concentrator holding portion 102 may also hold the filter 10 and the concentrator 20 in a state where the axial direction of the filter 10 and the concentrator 20 is oriented in the horizontal direction. The state where the axial direction of the filter 10 and the concentrator 20 is oriented in the up-down direction mentioned here refers to a concept that also includes a situation where the axial direction of the filter 10 and the concentrator 20 is inclined at about 0 to 45 degrees relative to the vertical direction. In addition, the state where the axial direction of the filter 10 and the concentrator 20 is oriented in the horizontal direction mentioned here refers to a concept that also includes a situation where the axial direction of the filter 10 and the concentrator 20 is inclined at about 0 to 45 degrees relative to the horizontal direction.

[0221] The raw liquid treatment device 1 of the first embodiment does not necessarily have the filter holding portion 101 and the concentrator holding portion 102. However, if the main body 100 has the filter holding portion 101 and the concentrator holding portion 102, there is an advantage that it is not necessary to separately prepare a holder for holding the filter 10 and the concentrator 20.

[0222] <A pair of hanging parts 103, 103>

[0223] like Fig.13 , Fig.14 as well as Fig.19 As shown in FIG. 1 , a pair of hanging parts 103, 103 are provided on the back of the main body 100. The pair of hanging parts 103, 103 are formed of shaft-shaped members, and the base ends of the shafts are detachably mounted on a pair of mounting parts 100h, 100h provided on the back of the main body 100. More specifically, the pair of mounting parts 100h, 100h are provided so that when the base ends of the pair of hanging parts 103, 103 are mounted on the pair of mounting parts 100h, 100h, the axial directions of the pair of hanging parts 103, 103 become substantially vertical.

[0224] The pair of hanging parts 103, 103 is provided with a hook part 103b similar to a general intravenous drip stand. And the pair of hanging parts 103, 103 can hang each bag B on the hook part 103b.

[0225] Furthermore, the pair of hanging parts 103 and 103 is provided with a hook part 103 f , and the pipe holder 150 can be hung on the hook part 103 f .

[0226] In addition, the pair of hanging parts 103, 103 does not necessarily need to be attachable and detachable to the main body 100. However, if the pair of hanging parts 103, 103 is attachable and detachable, the following advantage can be obtained: by removing the pair of hanging parts 103, 103 when the raw liquid processing device 1 of the first embodiment is not in use, the raw liquid processing device 1 of the first embodiment can be compactly accommodated.

[0227] In addition, the number of the hanging parts 103 provided in the stock solution processing apparatus 1 of the first embodiment is not limited to two, and may be one, or may be three or more. It is sufficient to provide an appropriate number of hanging parts 103 in accordance with the number of bags B, the number of tubes T, etc. used in the processing performed in the stock solution processing apparatus 1 of the first embodiment.

[0228] In addition, the stock solution treatment device 1 of the first embodiment does not necessarily have to have a pair of hanging parts 103, 103. In this case, a general drip stand for hanging drips can be used. However, if the main body 100 has a pair of hanging parts 103, 103, there is an advantage that there is no need to prepare a drip stand separately.

[0229] <Pipe support 150>

[0230] like Fig.18 As shown in FIG. 1 , the tube holder 150 is a component for holding a plurality of tubes T. If the tube holder 150 holds a plurality of tubes T in advance, Fig.18 As shown, a plurality of tubes T can be pre-suspended on a pair of suspension parts 103, 103 (see Fig.19 ). Thus, when installing the plurality of tubes T in the control unit 106, the filter 10, the concentrator 20, and the pair of roller pumps 110 and 120 of the main body 100, only the necessary tubes T can be removed from the tube holder 150 to perform the operation. That is, when installing the plurality of tubes T in the device, it is not necessary for the operator to hold the tubes T that are not immediately used in advance, so that the operator's operation becomes easy.

[0231] <Main body 151>

[0232] like Fig.18 As shown in FIG. 1 , the pipe holder 150 includes a plate-shaped main body 151. A connecting portion 152 is provided at an upper edge 151a of the main body 151. The connecting portion 152 is formed with a through hole 152h that passes through the inside and outside. By passing the hooks 103f of the pair of hanging portions 103, 103 through the through hole 152h, the pipe holder 150 can be hung on the hanging portion 103 with its upper edge 151a facing upward.

[0233] In order to stably hang the pipe holder 150 on the pair of hanging parts 103, 103 in a state where the upper end edge 151a of the pipe holder 150 faces upward, it is desirable that the through hole 152h and the hook parts 103f of the pair of hanging parts 103, 103 have a horizontally long shape. That is, it is desirable that the through hole 152h of the connecting part 152 is a horizontally long hole that is long in the direction along the upper end edge 151a. In addition, it is desirable that the hook parts 103f of the pair of hanging parts 103, 103 also have a horizontally long shape that is long in the direction orthogonal to the axial direction of the pair of hanging parts 103, 103.

[0234] <Holding Unit 155>

[0235] A plurality of holding portions 155 for holding the tube T in a detachable manner are provided on the surface 151c (first surface) of the main body 151. The holding portion 155 has a cylindrical structure, and a slit-shaped opening 155s is formed on the front surface thereof. The cylindrical structure has a through hole 155h that passes through in the vertical direction. The width of the opening 155s of the through hole 155h of the holding portion 155 is smaller than the diameter of the tube T. That is, the tube T can be arranged in the through hole 155h of the holding portion 155 by simply pushing the tube T from the opening 155s into the through hole 155h, and the tube T can be removed from the holding portion 155 by simply pulling the tube T.

[0236] The plurality of holding parts 155 are arranged in a row along the upper edge 151a of the main body 151. Furthermore, the plurality of holding parts 155 are arranged so that the central axes of the through holes 155h are parallel to each other. Therefore, if the plurality of tubes T are held by the plurality of holding parts 155, the plurality of tubes T can be arranged in a row along the surface 151c of the main body 155 with their axial directions parallel to each other. Thus, if the plurality of tubes T are pre-installed in the order determined by the plurality of holding parts 155, it is possible to prevent the operator from making a mistake such as misplacing the plurality of tubes T. For example, the plurality of tubes T are pre-installed in the plurality of holding parts 155 from the left side of the plurality of holding parts 155 to the right side of the plurality of holding parts 155 so that the plurality of tubes T are arranged in sequence in the order of connection with the device. Thus, as long as the operator removes the tubes T in sequence from the left, the connected tube T will not be mistaken, so it is possible to prevent operational mistakes and reduce the operational burden of the operator.

[0237] In addition, “the plurality of retaining portions 155 are arranged in a row along the upper edge 151 a of the main body 151 ” also includes a case where the plurality of retaining portions 155 are arranged in a staggered manner or are slightly offset in a direction intersecting the upper edge 151 a of the main body 151 .

[0238] <Engaging member 153>

[0239] In addition, the connecting portion 152 has a locking member 153 on the back side 151d (i.e., the second surface on the opposite side of the surface 151c) of the main body 151. The locking member 153 is provided in a state of protruding toward the back side 151d of the main body 151, and has an opening 153s at one end (upper end) thereof, and has a gap 153h continuous with the opening 153s.

[0240] If such a snap-fitting part 153 is provided in advance, the tubes T of the plurality of holding parts 155 held on the main body 151 can be directed downward at once in advance, or the tubes T can be maintained in a downward state in advance. For example, if the edge of a bucket or the like is inserted into the gap 153h through the opening 153s, the tube holder 150 can be mounted on the bucket or the like in such a manner that the upper end edge 115a of the main body 151 is in a downward state. Thus, if the plurality of tubes T are mounted on the plurality of holding parts 155 in advance in such a manner that the front ends thereof are directed toward the upper end edge 115a side of the main body 151 (upward in a state where the main body 151 is suspended by the hanging part 103), the front ends of the plurality of tubes T can be arranged in a downward direction at once. That is, when liquid is discharged from the plurality of tubes T to the bucket or the like, the liquid can be discharged from the plurality of tubes T simply by mounting the snap-fitting part 153 on the edge of the bucket or the like.

[0241] The shape of the connection portion 152 is not limited to the above-described shape, etc. Any shape may be used as long as the main body 151 and the pair of hanging portions 103 , 103 can be connected in advance.

[0242] Furthermore, the shape of the engaging member 153 is not limited to the above-mentioned shape, and any shape may be used as long as it has the above-mentioned function. Furthermore, the engaging member 153 is not necessarily required to be provided.

[0243] Furthermore, in the above example, the engaging member 153 is provided on the back surface 151d of the main body 151, but the engaging member 153 may be provided on the front surface 151c of the main body 151, or on both the front surface 151c and the back surface 151d of the main body 151.

[0244] <Filter 10 and Concentrator 20>

[0245] Before describing the circuit of the raw liquid treatment device 1 of the first embodiment, an example of a filter and a concentrator used in the raw liquid treatment device 1 of the first embodiment will be described. In addition, in the following, a filter and a concentrator using a hollow fiber membrane as a filtering component will be described, but the filter and the concentrator used in the raw liquid treatment device 1 of the first embodiment are not limited to the filter and the concentrator using the hollow fiber membrane as the filtering component, and a filter and a concentrator using a known filtering component other than the hollow fiber membrane can also be used.

[0246] <Filter 10>

[0247] The filter 10 is, for example, a peritoneal fluid filter used in CART, a plasma separator used in plasma exchange, a plasma component separator, etc. The filter 10 contains a filter component inside, and can filter the original fluid such as pleural and peritoneal effusion by the filter component to separate it into a filtrate and a separated liquid containing cells, etc.

[0248] like Figure 5 As shown, the filter 10 includes a main body 11 and a hollow fiber membrane bundle 15 disposed in the main body 11 .

[0249] <Hollow fiber membrane bundle 15>

[0250] like Figure 5 As shown, the hollow fiber membrane bundle 15 is formed by bundling a plurality of hollow fiber membranes 16 .

[0251] The hollow fiber membrane 16 is a tubular member having a wall 16w with an annular cross section and an axial through-flow path 16h formed inside the wall 16w to penetrate the hollow fiber membrane 16. The wall 16w of the hollow fiber membrane 16 has the function of impermeability to solid components such as cells and gases but permeability to liquids.

[0252] The thickness of the wall 16w of the hollow fiber membrane 16 is about 45 to 275 μm, and the diameter of the through-flow path 16h is about 50 to 500 μm, but the thickness of the wall 16w of the hollow fiber membrane 16 and the diameter of the through-flow path 16h are not particularly limited.

[0253] The hollow fiber membrane bundle 15 is formed by bundling the plurality of hollow fiber membranes 16 at one end and at the other end so that the through-flow passage 16h of each hollow fiber membrane 16 penetrates between the one end and the other end of the hollow fiber membrane bundle 15.

[0254] The two ends of the plurality of hollow fiber membranes 16 are not necessarily bound together. In this case, the plurality of hollow fiber membranes 16 are arranged so that both ends of the through-flow passages 16h communicate with the pair of headers 13 and 14 of the body 11, respectively.

[0255] In addition, the number of hollow fiber membranes 16 constituting the hollow fiber membrane bundle 15 is not particularly limited. For example, about 1,000 to 20,000 hollow fiber membranes 16 may be bundled into the hollow fiber membrane bundle 15. In addition, a plurality of hollow fiber membranes 16 may be bundled into the hollow fiber membrane bundle 15 in such a manner that the cross-sectional area of ​​the hollow fiber membrane bundle 15 becomes a desired cross-sectional area without limiting the number of hollow fiber membranes. For example, if the cross section of the hollow fiber membrane bundle 15 is circular, the plurality of hollow fiber membranes 16 may be bundled in such a manner that the diameter thereof reaches about 20 to 75 mm.

[0256] <Main body 11>

[0257] like Figure 5 As shown, the main body 11 is provided with a trunk 12, and the trunk 12 has a space that is airtightly and liquid-tightly isolated from the outside, that is, an internal space 12h. The internal space 12h of the trunk 12 is formed to be connected to the outside only through a port described later, and the above-mentioned hollow fiber membrane bundle 15 is accommodated inside. In a state where the above-mentioned hollow fiber membrane bundle 15 is accommodated inside, the internal space 12h is airtightly separated from the through-flow path 16h of the plurality of hollow fiber membranes 16, but the liquid can pass through the wall 16w. That is, the liquid in the internal space 12h can be supplied to the through-flow path 16h, and the liquid in the through-flow path 16h can be supplied to the internal space 12h.

[0258] In addition, the size and shape of the internal space 12h are not particularly limited. In the state where the hollow fiber membrane bundle 15 is accommodated, the liquid flowing into the internal space 12h through the port flows between the hollow fiber membrane bundle 15 and the inner surface of the trunk 12 (i.e., the inner surface of the internal space 12h) and between the plurality of hollow fiber membranes 16, as long as it has a size that can flow into the through-flow path 16h through the wall 16w of the hollow fiber membrane 16. In addition, the liquid (filtrate) flowing out from the through-flow path 16h to the internal space 12h through the wall 16w of the hollow fiber membrane 16 flows between the plurality of hollow fiber membranes 16 and between the hollow fiber membrane bundle 15 and the inner surface of the internal space 12h, as long as it has a size that can flow out from the port.

[0259] like Figure 5 As shown, a pair of manifolds 13 and 14 are provided in the main body 11 in a manner of sandwiching the trunk 12, that is, sandwiching the internal space 12h. The pair of manifolds 13 and 14 are spaces that are airtightly and liquid-tightly isolated from the internal space 12h of the trunk 12 and the outside, and are formed as spaces that are connected to the outside only through the port described later. In addition, the ends of the above-mentioned hollow fiber membrane bundle 15 are respectively connected to the pair of manifolds 13 and 14. Specifically, the two ends of the hollow fiber membrane bundle 15 are respectively connected to the pair of manifolds 13 and 14, so that the openings at both ends of the through-flow path 16h of the multiple hollow fiber membranes 16 constituting the hollow fiber membrane bundle 15 are connected to the internal spaces of the pair of manifolds 13 and 14. Therefore, the internal spaces of the pair of manifolds 13 and 14 are connected to each other through the through-flow path 16h of the multiple hollow fiber membranes 16 constituting the hollow fiber membrane bundle 15.

[0260] <Ports 11a to 11c>

[0261] As described above, the main body 11 is provided with a port 11c for communicating the internal space 12h formed in the trunk 12 of the main body 11 with the outside. The pair of headers 13 and 14 are provided with ports 11a and 11b for communicating the internal space with the outside, respectively.

[0262] like Figure 5 As shown in FIG. 1 , the manifold 13 disposed at one end of the main body 11 is provided with a raw liquid supply port 11a for communicating the space inside the manifold 13 with the outside. The raw liquid supply port 11a is a port to which one end of a tube or the like is connected. For example, if Figure 1 In the embodiment, one end of the liquid supply tube 2 is connected to the raw liquid supply port 11a, and the other end of the liquid supply tube 2 is connected to the liquid discharge port of the raw liquid bag UB.

[0263] In addition, if Figure 1In the embodiment, the cleaning liquid recovery bag FB is connected to the stock liquid supply port 11a via the liquid supply pipe 2, or is directly connected to the stock liquid supply port 11a. Specifically, one end of the cleaning liquid recovery pipe 7 is connected to the liquid supply pipe 2 or the stock liquid supply port 11a, and the other end of the cleaning liquid recovery pipe 7 is connected to the cleaning liquid recovery bag FB.

[0264] Two ports 11c are provided on the side of the trunk 12 of the main body 11 to communicate the internal space 12h with the outside. The two ports 11c are ports to which one end of a tube or the like is connected. Figure 1 In the embodiment, one end of the filtrate supply pipe 3 is connected to the lower port 11c, and the other end of the filtrate supply pipe 3 is connected to the filtrate supply port 20a of the concentrator 20. That is, the lower port 11c functions as a filtrate discharge port 11c for discharging the filtrate to the outside. On the other hand, the upper port 11c can function as a filtrate discharge port 11c for discharging the filtrate to the outside in the same way as the lower port 11c, and can also function as a port for supplying fluids such as liquids (cleaning fluids, etc.) and gases (air, etc.) from the outside to the trunk 12 of the main body 11 or for discharging fluids such as liquids (filtrate, cleaning fluids, etc.) and gases (air, etc.) from the trunk 12 of the main body 11. In addition, in Figure 5 Although two ports 11c are provided, one port 11c may be provided, or three or more ports 11c may be provided.

[0265] The manifold 14 provided at the other end of the main body 11 is provided with a cleaning liquid supply port 11b for communicating the space inside the manifold 14 with the outside. The cleaning liquid supply port 11b is a port to which one end of a tube or the like is connected. Figure 1 In the embodiment, one end of a cleaning liquid supply tube 6 is connected to the cleaning liquid supply port 11b, and the other end of the cleaning liquid supply tube 6 is connected to the cleaning liquid bag SB.

[0266] In addition, the pair of manifolds 13 and 14 correspond to the first liquid supply part and the second liquid supply part mentioned in the claims. The pair of manifolds 13 and 14 may be such that the manifold 13 is the first liquid supply part and the manifold 14 is the second liquid supply part, or the manifold 13 is the second liquid supply part and the manifold 14 is the first liquid supply part.

[0267] <Function of filter 10>

[0268] Since the filter 10 has the above-described configuration, it is possible to supply and discharge a fluid such as a liquid or a gas to each of the ports 11 a to 11 c via a tube or the like.

[0269] For example, Figure 1As shown, if the stock liquid bag UB and the cleaning liquid bag SB are connected to the ports 11a to 11c via the respective tubes, a filtrate obtained by filtering the stock liquid can be obtained. That is, the liquid supply tube liquid delivery portion 2p can be operated to supply the stock liquid from the stock liquid bag UB to the manifold portion 13 of the main body 11 via the liquid supply tube 2 and the stock liquid supply port 11a. Thus, since the stock liquid is supplied to the through-flow path 16h of the hollow fiber membrane 16 of the hollow fiber membrane bundle 15, the stock liquid can be filtered by the hollow fiber membrane 16. That is, since the solid components contained in the stock liquid cannot pass through the hollow fiber membrane 16, they remain in the through-flow path 16h, and only the liquid component, that is, the filtrate, passes through the wall 16w of the hollow fiber membrane 16, so that the filtrate obtained by filtering the stock liquid can be obtained.

[0270] In addition, if Figure 1 As shown, the tube is connected to each port 11a~11c of the filter 10, and the filtrate is discharged from the hollow fiber membrane 16 to the internal space 12h of the trunk 12 of the main body 11, and then supplied from the internal space 12h to the concentrator 20 through the filtrate discharge port 11c, the filtrate supply pipe 3 and the filtrate supply port 20a of the concentrator 20.

[0271] On the other hand, if we assume Figure 1 In the circuit shown in FIG. 1 , if the cleaning liquid recovery pipe liquid delivery portion 7p (or the liquid supply pipe liquid delivery portion 2p) is operated to suck the liquid out of the filter 10, the filter 10 can be cleaned. That is, since the cleaning liquid can be supplied from the cleaning liquid bag SB to the manifold portion 14 of the main body 11 via the cleaning liquid supply pipe 6 and the cleaning liquid supply port 11b, the cleaning liquid can be supplied from the manifold portion 14 to the through-flow path 16h of the hollow fiber membrane 16 (see FIG. 1 ). Figure 5 ). As a result, the cleaning liquid flows from the manifold 14 toward the manifold 13 by the force of sucking out the fluid generated by the cleaning liquid recovery pipe delivery portion 7p, so that the inside of the through-flow path 16h of the hollow fiber membrane 16, especially the inner surface of the through-flow path 16h (the inner surface of the wall 16w) can be cleaned by the cleaning liquid flowing along the inner surface of the through-flow path 16h. As a result, solid components and the like attached to the inner wall of the through-flow path 16h of the hollow fiber membrane 16 can be effectively washed away.

[0272] <Cleaning of filter 10>

[0273] In particular, the hollow fiber membrane 16 can be cleaned efficiently by performing the following operation.

[0274] In the following cleaning operation, the filtration operation is performed in a state where the raw liquid supply port 11 a is located above the cleaning liquid supply port 11 b , and the cleaning operation is performed in the same state.

[0275] like Fig.21 As shown, the filtrate supply pipe 3 and the connecting pipe 9 are closed by the flow rate adjustment mechanism 3c provided in the filtrate supply pipe 3 and the connecting pipe liquid delivery portion 9p provided in the connecting pipe 9. On the other hand, the cleaning liquid supply pipe 6 is opened by the flow rate adjustment mechanism 6c. In this state, the cleaning liquid recovery pipe liquid delivery portion 7p of the cleaning liquid recovery pipe 7 is operated.

[0276] Thus, negative pressure is generated in the cleaning liquid recovery pipe 7 at the upstream side of the cleaning liquid recovery pipe liquid feeding portion 7p, that is, at the filter 10 side. When such negative pressure is generated, the cleaning liquid flows from the cleaning liquid bag SB connected to the cleaning liquid supply pipe 6 through the cleaning liquid supply pipe 6, the cleaning liquid supply port 11b, the header 14, the through flow path 16h of the hollow fiber membrane 16, the header 13, and the raw liquid supply port 11a into the cleaning liquid recovery pipe 7 due to the negative pressure.

[0277] At this time, since the filtrate supply pipe 3 and the connecting pipe 9 are closed, the cleaning liquid does not flow from the hollow fiber membrane 16 to the internal space 12h, but flows only in the through-flow path 16h of the hollow fiber membrane 16. Thus, only the through-flow path 16h between the pair of headers 13 and 14 and the hollow fiber membrane 16 can be cleaned by the cleaning liquid, so the cleaning liquid used for cleaning the filter 10 can be reduced.

[0278] Furthermore, since the internal space 12h is not cleaned, even if the filter 10 is cleaned after filtering and concentrating, the filtrate remains in the internal space 12h. Thus, the filtrate in the internal space 12h can be prevented from being discharged together with the cleaning liquid, thereby preventing a decrease in the recovery rate of the filtrate.

[0279] When cleaning the filter 10 , both the liquid supply pipe liquid delivery portion 2 p of the liquid supply pipe 2 and the cleaning liquid recovery pipe liquid delivery portion 7 p of the cleaning liquid recovery pipe 7 may be operated.

[0280] In addition, when cleaning the filter 10, the liquid feeding pipe liquid feeding part 2p may be operated instead of the cleaning liquid recovery pipe liquid feeding part 7p. In this case, since the stock liquid in the through-flow path 16h of the hollow fiber membrane 16 can be recovered to the stock liquid bag UB together with the cleaning liquid, if the cleaning liquid containing the recovered stock liquid is supplied to the filter 10 again, it is possible to prevent the amount of the stock liquid used in the filtration concentration from decreasing.

[0281] Furthermore, as described above, when both or one of the liquid supply pipe liquid supply portion 2p and the cleaning liquid recovery pipe liquid supply portion 7p are operated, negative pressure is also generated in the through-flow path 16h of the hollow fiber membrane 16. Thus, even if solid components are clogged inside the wall 16w of the hollow fiber membrane 16, the solid components can be sucked out, and thus the clogging of the wall 16w of the hollow fiber membrane 16 can be eliminated.

[0282] In addition, when the main purpose is to eliminate the clogging of the wall 16w of the hollow fiber membrane 16, the cleaning liquid bag SB may be connected to the connecting pipe 9 (see Fig.21 ), and the connecting pipe liquid feeding part 9p is operated so that the cleaning liquid flows from the cleaning liquid bag SB toward the filter 10. In this case, since the cleaning of the internal space 12h is also substantially carried out, although the amount of cleaning liquid used is increased, it becomes easier to eliminate the clogging of the wall 16w of the hollow fiber membrane 16. That is, in addition to the suction effect caused by the negative pressure mentioned above, the pushing effect of the cleaning liquid by the connecting pipe liquid feeding part 9p is also produced, so it becomes easier to eliminate the clogging of the wall 16w of the hollow fiber membrane 16. In addition, when the suction effect of the liquid feeding pipe liquid feeding part 2p and the cleaning liquid recovery pipe liquid feeding part 7p is large enough, it is also possible to maintain only the connecting pipe 9 in a manner that the cleaning liquid supplied from the cleaning liquid bag SB flows inside the connecting pipe 9. For example, a clamp or the like is provided in the connecting pipe 9 instead of the connecting pipe liquid feeding part 9p, and even if only the connecting pipe 9 is opened in advance, the cleaning of the internal space 12h and the elimination of the clogging of the wall 16w of the hollow fiber membrane 16 can be effectively carried out.

[0283] Furthermore, when the cleaning operation is performed as described above, it becomes easy to eliminate the clogging of the header section 13 to which the raw liquid is supplied.

[0284] In the manifold 13 to which the stock solution is supplied, the solid components contained in the stock solution are supplied to the liquid supply pipe 2 as is, so when the solid components are large, the opening of the through-flow path 16h of the hollow fiber membrane 16 may be clogged with the solid components. However, as described above, if a negative pressure is generated in the cleaning liquid recovery pipe 7 at a position closer to the filter 10 than the cleaning liquid recovery pipe liquid delivery portion 7p, the solid components can be sucked out from the manifold 13 to the cleaning liquid recovery pipe 7 by the negative pressure, so that the blockage of the manifold 13 can be eliminated. In this case, the cleaning liquid bag SB can also be connected to the connecting pipe 9 in advance, and the connecting pipe liquid delivery portion 9p can be operated so that the cleaning liquid flows from the cleaning liquid bag SB toward the filter 10. As a result, in addition to the above-mentioned suction effect caused by the negative pressure, the cleaning liquid is pushed in by the connecting pipe liquid delivery portion 9p, so that it becomes easier to eliminate the blockage of the manifold 13.

[0285] In the above example, the cleaning liquid is caused to flow in the opposite direction to the direction in which the stock solution flows. However, the cleaning liquid may be caused to flow in the same direction as the direction in which the stock solution flows (i.e., the direction in which the stock solution flows during filtration and concentration). Even in this case, there is a possibility that the wall 16w of the hollow fiber membrane 16 may be prevented from being clogged. For example, in Fig.21In the embodiment, the cleaning liquid recovery bag FB is connected to the connecting pipe 9 instead of the cleaning liquid bag SB, and the connecting pipe liquid feeding part 9p is operated in a manner that the liquid flows from the filter 10 to the cleaning liquid recovery bag FB. At this time, if the operation of the liquid feeding pipe liquid feeding part 2p and the cleaning liquid recovery pipe liquid feeding part 7p is stopped in advance, the cleaning liquid supplied from the cleaning liquid bag SB connected to the cleaning liquid supply pipe 6 can flow in a manner that passes through the wall 16w of the hollow fiber membrane 16, so there is a possibility that the solid components blocked in the wall 16w of the hollow fiber membrane 16 can be pushed out. In this case, the liquid feeding pipe liquid feeding part 2p or the cleaning liquid recovery pipe liquid feeding part 7p can also be operated. In this way, the elimination of the blockage of the wall 16w of the hollow fiber membrane 16 and the cleaning of the through-flow path 16h of the hollow fiber membrane 16 can be implemented simultaneously.

[0286] In addition, in the case of the above method (the case where the cleaning liquid is made to flow in the direction of the flow of the stock liquid during filtration and concentration), after the cleaning of the through-flow path 16h of the hollow fiber membrane 16 is implemented, the cleaning liquid can be made to flow in a manner that passes through the wall 16w of the hollow fiber membrane 16. That is, the liquid supply pipe liquid supply part 2p or the cleaning liquid recovery pipe liquid supply part 7p is initially operated in a state where the operation of the connecting pipe liquid supply part 9p is stopped. Thus, since the cleaning liquid can flow in the through-flow path 16h of the hollow fiber membrane 16, the through-flow path 16h can be cleaned, thereby removing the deposits in the through-flow path 16h. Then, the operation of the liquid supply pipe liquid supply part 2p and the cleaning liquid recovery pipe liquid supply part 7p is stopped, and the connecting pipe liquid supply part 9p is operated. Thus, since the cleaning liquid can flow in a manner that passes through the wall 16w of the hollow fiber membrane 16, the blockage of the wall 16w of the hollow fiber membrane 16 can be eliminated. Furthermore, in the case of this method, since the deposits in the through flow passages 16h of the hollow fiber membranes 16 can be removed in advance, it is possible to prevent the walls 16w of the hollow fiber membranes 16 from being clogged with the deposits.

[0287] In addition, the above method can be similarly implemented even in the following case: the stock solution is supplied into the hollow space 12h of the trunk portion 12, and the stock solution is caused to flow from the hollow space 12h of the trunk portion 12 into the through flow path 16h of the hollow fiber membrane 16, thereby filtering the stock solution. In this case, after the hollow space 12h of the trunk portion 12 is cleaned, the cleaning liquid may be caused to flow in a manner that passes through the wall 16w of the hollow fiber membrane 16.

[0288] <Another Example of Cleaning the Filter 10>

[0289] exist Figure 1 , Figure 7 , Fig.11When the filter 10 is cleaned during the filtering and concentration operation in the circuit shown in the figure, or after the filtering and concentration operation is completed, the through-flow path 16h of the hollow fiber membrane 16 of the filter 10 or the space in the pair of manifolds 13 and 14 is filled with the stock solution, and the internal space 12h of the trunk 12 is filled with the filtrate. In this state, the clogging in the specified area of ​​the hollow fiber membrane 16 can be removed by supplying the cleaning liquid from the cleaning liquid supply port 11b or the filtrate discharge port 11c. That is, the position (for example, the position of the internal space 12h of the trunk filled with the filtrate) can be cleaned. Fig. 20 The blockage of the hollow fiber membrane 16 is removed until the position H1 is reached.

[0290] However, when the filter 10 is cleaned in the middle of the filtration and concentration operation, the operation of discharging the raw liquid in the through-flow passage 16h of the hollow fiber membrane 16 and the space of the pair of headers 13 and 14 and the operation of discharging the filtrate in the internal space 12h of the trunk portion (the recovery operation described later) may be performed temporarily before the filter 10 is cleaned. In other words, the raw liquid in the through-flow passage 16h of the hollow fiber membrane 16 and the space of the pair of headers 13 and 14 may be kept as it is, and the filter 10 may be cleaned after the filtrate in the internal space 12h of the trunk portion is discharged. On the contrary, the filtrate in the internal space 12h of the trunk portion may be kept as it is, and the filter 10 may be cleaned after the raw liquid in the through-flow passage 16h of the hollow fiber membrane 16 and the space of the pair of headers 13 and 14 is discharged. In this case, even if a liquid such as a cleaning liquid (filling liquid) is supplied to the through-flow path 16h of the hollow fiber membrane 16 or the internal space 12h of the trunk 12, the blockage of the hollow fiber membrane 16 can be removed only in the area where the filling liquid exists in the internal space 12h of the trunk 12 or the through-flow path 16h of the hollow fiber membrane 16.

[0291] Therefore, when performing both or one of the operation of discharging the raw liquid in the through-flow passage 16h of the hollow fiber membrane 16 and the space in the pair of headers 13 and 14 and the operation of discharging the filtrate in the internal space 12h of the trunk portion (a recovery operation described later), it is desirable to supply the cleaning liquid to the filter 10 in a manner that the cleaning liquid permeates the hollow fiber membrane 16 in a state where the hollow space 12h of the trunk portion 12 and / or the through-flow passage 16h of the hollow fiber membrane 16 is filled with the filling liquid until the region to be cleaned in the hollow fiber membrane 16 is filled. In other words, it is desirable to supply the cleaning liquid to the filter 10 in a manner that the cleaning liquid permeates the hollow fiber membrane 16 in a state where the entire or a part of the hollow fiber membrane 16 is filled with the filling liquid.

[0292] In addition, when the cleaning liquid is caused to flow from the outside of the hollow fiber membrane 16, that is, from the internal space 12h of the trunk portion into the through-flow path 16h of the hollow fiber membrane 16, the through-flow path 16h of the hollow fiber membrane 16 does not necessarily have to be filled with the filling liquid to clean the area. However, the internal space 12h of the trunk portion 12 needs to be filled with the filling liquid to clean the area. In addition, when the cleaning liquid is caused to flow from the inside of the hollow fiber membrane 16, that is, from the through-flow path 16h of the hollow fiber membrane 16 into the internal space 12h of the trunk portion for cleaning (when the cleaning liquid is caused to flow in the direction of the flow of the raw liquid during the above-mentioned filtration and concentration), the through-flow path 16h of the hollow fiber membrane 16 needs to be filled with the filling liquid to clean the area.

[0293] In addition, the filling liquid filling the hollow space 12h of the trunk 12 and / or the through-flow path 16h of the hollow fiber membrane 16 is not limited to the cleaning liquid (such as physiological saline or infusion (extracellular fluid) etc.) used for cleaning. For example, a liquid containing waste liquid or a substance that improves the cleaning effect (such as a surfactant etc.) can be used as the filling liquid, or a stock liquid can be used.

[0294] In addition, the cleaning liquid used in cleaning is not particularly limited as long as it can be a liquid used in cleaning. For example, liquids containing waste liquid or substances that improve cleaning effects (e.g., surfactants, etc.) can also be used as cleaning liquids, or stock solutions can be used.

[0295] In the following description, a case where a cleaning liquid generally used in cleaning is used as the filling liquid and the cleaning liquid is described.

[0296] For example, if Fig.21 In the process, first, the filtrate supply pipe 3 is pre-closed by the flow regulating mechanism 3c and the operation of both the liquid supply pipe liquid delivery portion 2p and the cleaning liquid recovery pipe liquid delivery portion 7p is stopped. In addition, the cleaning liquid supply pipe 6 is also pre-closed by the flow regulating mechanism 6c. Then, when the hollow space 12h of the trunk 12 is filled with the cleaning liquid, the upper port 11c is opened to the atmosphere. In addition, when the through-flow path 16h of the hollow fiber membrane 16 is filled with the cleaning liquid, a portion of the liquid supply pipe 2 and / or the cleaning liquid recovery pipe 7 that is closer to the through-flow path 16h side of the hollow fiber membrane 16 than the liquid supply pipe liquid delivery portion 2p and / or the cleaning liquid recovery pipe liquid delivery portion 7p (for example, at Fig.21In this state, the connecting pipe liquid delivery part 9p is operated to supply cleaning liquid from the cleaning liquid bag SB to the hollow space 12h of the trunk 12. In addition, the cleaning liquid is filled in the hollow space 12h of the trunk 12 and / or the through-flow path 16h of the hollow fiber membrane 16 until the area to be cleaned, for example, the area where the filtrate exists in the filtration concentration operation (for example, Fig. 20 The height of H1).

[0297] After the cleaning liquid is filled into the above-mentioned area, the connection pipe liquid feeding part 9p is kept in the state of being operated, the cleaning liquid supply pipe 6 is opened by the flow control mechanism 6c, and the cleaning liquid recovery pipe liquid feeding part 7p is operated. In this way, the hollow fiber membrane 16 and the hollow space 12h of the trunk 12 can be cleaned by the cleaning liquid supplied from the cleaning liquid bag SB connected to the cleaning liquid supply pipe 6 and the connection pipe 9, and the clogging of the hollow fiber membrane 16 in the cleaning area can be eliminated.

[0298] Furthermore, during the cleaning process, the control unit 106 controls the flow rate sucked out by the cleaning liquid recovery pipe liquid delivery unit 7p to be slightly larger than the flow rate of the cleaning liquid supplied from the connection pipe 9. That is, cleaning can be performed in the following manner: while the cleaning liquid is maintained in the region where the filtrate exists in the filtration and concentration operation, the cleaning liquid supplied from the cleaning liquid supply pipe 6 flows in the through-flow path 16h of the hollow fiber membrane 16.

[0299] In addition, before cleaning, the cleaning liquid is not separately filled into the area to be cleaned, but the cleaning liquid recovery pipe liquid feeding portion 7p is operated while the cleaning liquid supply pipe 6 is opened by the flow control mechanism 6c, and the connecting pipe liquid feeding portion 9p is operated to supply the cleaning liquid from the cleaning liquid bag SB into the hollow space 12h of the trunk portion 12. Even in this case, as long as the operation of the connecting pipe liquid feeding portion 9p and the cleaning liquid recovery pipe liquid feeding portion 7p is controlled by the control unit 106, the cleaning liquid can be filled into the hollow space 12h of the trunk portion 12 up to the area to be cleaned.

[0300] For example, the cleaning liquid supply pipe 6 is closed in advance by using the flow adjustment mechanism 6c, and the upper port 11c is set to a state open to the atmosphere, so that the connecting pipe liquid delivery part 9p and the cleaning liquid recovery pipe liquid delivery part 7p are operated. At this time, the flow rate of the cleaning liquid supplied from the connecting pipe 9 is set in advance to be greater than the flow rate sucked out by the cleaning liquid recovery pipe liquid delivery part 7p. Thus, as time passes, the cleaning liquid can be filled into the hollow space 12h of the trunk 12 until the area to be cleaned. Then, as long as the cleaning liquid supply pipe 6 is opened by using the flow adjustment mechanism 6c, the upper port 11c is closed, and the flow rate of the cleaning liquid supplied from the connecting pipe 9 is less than the flow rate sucked out by the cleaning liquid recovery pipe liquid delivery part 7p, cleaning can be performed in a stable state. That is, the cleaning of the hollow fiber membrane 16 can be performed while maintaining the state of filling the cleaning liquid into the hollow space 12h of the trunk 12 until the area to be cleaned.

[0301] In addition, the cleaning liquid in the hollow space 12h of the trunk 12 may be sucked out by a pump provided in a pipe connected to the upper port 11c until the area to be cleaned in the hollow space 12h of the trunk 12 is filled with the cleaning liquid. In this case, the cleaning liquid supply pipe 6 may be opened by the flow adjustment mechanism 6c while the flow rate of the cleaning liquid supplied from the connecting pipe 9 is made greater than the flow rate sucked out by the cleaning liquid recovery pipe feeding portion 7p in advance. Even in this case, as long as the cleaning liquid is filled into the hollow space 12h of the trunk 12 until the area to be cleaned, the cleaning can be performed in a stable state by closing the upper port 11c and making the flow rate of the cleaning liquid supplied from the connecting pipe 9 less than the flow rate sucked out by the cleaning liquid recovery pipe feeding portion 7p. That is, the cleaning of the hollow fiber membrane 16 can be performed while maintaining the state in which the cleaning liquid is filled into the hollow space 12h of the trunk 12 until the area to be cleaned.

[0302] In addition, even when the flow rate of the cleaning liquid supplied from the connecting pipe 9 and the flow rate sucked out from the liquid delivery portion 7p of the cleaning liquid recovery pipe are made the same, the through flow path 16h of the hollow fiber membrane 16 can be filled with the cleaning liquid until the area to be cleaned, and cleaning can be performed in a state in which the through flow path 16h of the hollow fiber membrane 16 is filled with the cleaning liquid until the area to be cleaned.

[0303] In addition, although the cleaning liquid is filled to the area to be cleaned, the area to be cleaned is not necessarily limited to the area where the filtrate exists in the filtration and concentration operation, and may be an area smaller than the area (for example, until Fig. 20 The height of H3), or more than this area (for example, until Fig. 20 In addition, the hollow space 12h of the trunk 12 may be filled with cleaning liquid. Fig. 20 As shown in the figure, when only the lower port 11c (filtrate discharge port 11c) of the pair of ports 11c, 11c is connected to the filtrate supply pipe 3, the hollow space 12h is filled with the cleaning liquid until the cleaning liquid does not leak from the upper port 11c (until Fig. 20 The height of H2).

[0304] In the above example, the case where the axial direction of the hollow fiber membrane 16 of the filter 10 is oriented in the up-down direction is described, but there is also a case where the filter 10 is configured so that the axial direction of the hollow fiber membrane 16 is oriented in a substantially horizontal direction. In this case, it is desired to perform the cleaning operation in a state where the hollow fiber membrane 16 is immersed in the cleaning liquid as a whole (or after the cleaning liquid is filled into the hollow space 12h of the trunk 12 so that the hollow fiber membrane 16 is immersed in the cleaning liquid as a whole) in such a manner as to maintain this state. Of course, it is also possible to perform the cleaning operation in a state where only a portion of the hollow fiber membrane 16 is immersed in the cleaning liquid (or after the cleaning liquid is filled into the hollow space 12h of the trunk 12 so that a portion of the hollow fiber membrane 16 is immersed in the cleaning liquid) in such a manner as to maintain this state, depending on the position of the port 11c. The state in which only a part of the hollow fiber membrane 16 is immersed in the cleaning liquid corresponds to, for example, a state in which the cleaning liquid does not leak from the port 11 c to which the filtrate supply pipe 3 is not connected, although the entire hollow fiber membrane 16 is not immersed in the cleaning liquid.

[0305] In the above example, the cleaning liquid is supplied from the connecting pipe 9 connected to the filtrate supply pipe 3 to the hollow space 12h of the trunk 12. However, the cleaning liquid may not be supplied through the filtrate supply pipe 3. For example, Fig. 20 As shown, when the filtrate supply pipe 3 is connected only to the lower port 11c (filtrate discharge port 11c) of the pair of ports 11c, 11c, the cleaning liquid is supplied only from the upper discharge port 11c. In addition, when the cleaning liquid is supplied to the hollow space 12h of the trunk 12 through the filtrate supply pipe 3, the cleaning liquid may be supplied to the concentrator 20 connected to the filtrate supply pipe 3, and the cleaning liquid passing through the concentrator 20 may be supplied to the hollow space 12h of the trunk 12. In this case, when the filter 10 is cleaned, the concentrator 20 can also be cleaned (for example, the hollow fiber membrane of the filter 20 is cleaned).

[0306] For example, Fig. 22As shown, the cleaning liquid is supplied from the cleaning liquid bag SB directly to the concentrated liquid discharge port 20b of the concentrator 20 or supplied to the concentrator 20 via the concentrated liquid pipe 4 connected to the concentrated liquid discharge port 20b. Thus, the supplied cleaning liquid flows from the filtrate supply port 20a into the filtrate supply pipe 3 after passing through the concentrator 20, and is supplied from the filtrate supply pipe 3 through the filtrate discharge port 11c to the hollow space 12h of the body 12 of the filter 10. That is, the cleaning liquid supplied to the concentrator 20 can be used not only for cleaning the concentrator 20 but also for cleaning the filter 10.

[0307] In addition, in this case, the substance in the concentrator 20 flows in the hollow space 12h of the trunk 12, but the substance is the filtrate discharged from the filter 10 or the substance contained in the filtrate, and there is no problem even if it flows into the hollow space 12h of the trunk 12, as long as the filtrate diluted by the cleaning liquid is concentrated again.

[0308] In addition, the cleaning liquid may be supplied to the concentrator 20 through the waste liquid outlet 20c instead of the concentrated liquid outlet 20b. If the cleaning liquid is supplied to the concentrator 20 from the waste liquid outlet 20c, the cleaning liquid can flow in a direction perpendicular to the wall 16w of the hollow fiber membrane 16. That is, since the cleaning liquid can be supplied in a direction in which the cleaning liquid passes through the wall 16w of the hollow fiber membrane 16, the advantage of being able to efficiently push and flow the clogging components accumulated in the concentrator 20 for cleaning can be obtained.

[0309] <Detailed Description of Concentrator 20>

[0310] In the raw liquid processing apparatus 1 of the first embodiment, it is desirable that each tube is connected to the concentrator 20 as follows. Hereinafter, the configuration of the concentrator 20 and the connection of each tube to the concentrator 20 will be described.

[0311] The concentrator 20 is supplied with filtrate from the filter 10 and concentrates the filtrate. The concentrator 20 has substantially the same structure as the filter 10, and has the function of separating water from the filtrate to form a concentrated liquid. That is, the concentrator 20 has a structure in which a water separation component is housed instead of the separation component of the filter 10, and the water separation component has the function of separating water from the filtrate. For example, a peritoneal effusion concentrator for CART, a dialysis filter for dialysis, a membrane type plasma component fractionator for double filtration plasma exchange therapy, etc. are used for the concentrator 20.

[0312] Specifically, the concentrator 20 includes a filtrate supply port 20a connected to the filtrate discharge port 11c of the filter 10 via the filtrate supply pipe 3. That is, the filtrate, which is the liquid to be concentrated, is supplied to the concentrator 20 from the filtrate supply port 20a.

[0313] The concentrator 20 also includes a waste liquid outlet 20c for discharging the liquid (separated liquid, waste liquid) separated from the filtrate, that is, water, etc. The waste liquid outlet 20c is connected to the waste liquid bag DB via the waste liquid pipe 5. The concentrator 20 also includes a concentrated liquid outlet 20b for discharging the concentrated liquid. The concentrated liquid outlet 20b is connected to the concentrated liquid bag CB via the concentrated liquid pipe 4.

[0314] Furthermore, the concentrator 20 is provided with a water separation component. The water separation component has a function of allowing water to pass through but preventing useful components such as useful proteins contained in the plasma from passing through. Figure 5 Such a structure, Figure 5 The hollow fiber membrane bundle 15 becomes a moisture separation component.

[0315] Therefore, when the filtrate is supplied to the concentrator 20 from the filtrate supply port 20a, water is separated from the filtrate by the water separation member, and the separated water is discharged from the waste liquid discharge port 20c and supplied to the waste liquid bag DB through the waste liquid pipe 5. On the other hand, the concentrated liquid from which part of the water is removed is discharged from the concentrated liquid discharge port 20b, and the discharged concentrated liquid is supplied to the concentrated liquid bag CB through the concentrated liquid pipe 4 (see Figure 1 ).

[0316] When the concentrator 20 has a hollow fiber membrane as a water separation member, it has substantially the same structure as the filter 10 (see Figure 5 ). That is, it has the following structure, which has: a trunk having a hollow space for accommodating a plurality of hollow fiber membranes (or a hollow fiber membrane bundle obtained by bundling a plurality of hollow fiber membranes) as a moisture separation component, and a pair of headers that connect the two ends of the plurality of hollow fiber membranes. In addition, it has a structure in which the pair of headers have a port that serves as a filtrate supply port 20a or a concentrate discharge port 20b, and the trunk has a port that serves as a waste liquid discharge port 20c. For example, it is set at Figure 5 The port 11a of the manifold 13 becomes the filtrate supply port 20a, which is arranged Figure 5 The port 11b of the manifold 14 becomes the concentrated liquid discharge port 20b. Figure 5 The port 11c of the trunk 12 becomes the waste liquid outlet 20c. (See Figure 5 ).

[0317] Furthermore, in the case of the concentrator 20 having such a structure, the pair of headers (if Figure 5 The pair of headers 13 and 14 in the figure correspond to the first liquid supply section and the second liquid supply section in the claims.

[0318] Furthermore, when the concentrator 20 has substantially the same structure as the filter 10 , by cleaning the filter 10 in the same way as the filter 10 , clogging of the hollow fiber membrane can be removed and the flow path in the hollow fiber membrane can be cleaned efficiently.

[0319] For example, if Fig.21 In the embodiment of the present invention, the filtrate supply pipe 3 is first closed in advance by the flow rate adjustment mechanism 3c. In addition, the operation of the concentrate pipe liquid delivery part 4p is stopped in advance to close the concentrate pipe 4. Then, when the hollow space of the trunk of the concentrator 20 is filled with the cleaning liquid, the upper port 20c of the two ports 20c is opened to the atmosphere. In addition, when the through-flow path of the hollow fiber membrane is filled with the cleaning liquid, the portion of the filtrate supply pipe 3 closer to the hollow space of the trunk than the flow rate adjustment mechanism 3c is opened to the atmosphere. In this state, a cleaning liquid bag SB is connected to the other end of the waste liquid pipe 5 connected to the lower port 20c instead of the waste liquid bag DB, and the cleaning liquid is supplied from the cleaning liquid bag SB to the hollow space of the trunk of the concentrator 20. Then, in the hollow space of the trunk, the cleaning liquid is filled to the area to be cleaned, for example, the area where the waste liquid exists in the filtration and concentration operation.

[0320] After the cleaning liquid is filled in the above-mentioned area, the filtrate supply pipe 3 is opened by the flow control mechanism 3c, the connecting pipe liquid feeding part 9p is operated to supply the cleaning liquid from the cleaning liquid bag SB connected to the connecting pipe 9 to the concentrator, and the concentrated liquid pipe liquid feeding part 4p is also operated. In this way, the hollow fiber membranes and the hollow space of the trunk in the concentrator 20 can be cleaned, and the blockage of the hollow fiber membranes 16 in the cleaning area can be eliminated.

[0321] During the cleaning process, the flow rate of the concentrated liquid pipe liquid delivery portion 4p is controlled to be slightly larger than the flow rate of the cleaning liquid supplied from the connecting pipe liquid delivery portion 9p. That is, cleaning can be performed in such a manner that the cleaning liquid supplied from the waste liquid pipe 5 is allowed to pass through the hollow fiber membrane 16 while the cleaning liquid is maintained in the region where the concentrated liquid exists during the filtration and concentration operation.

[0322] In addition, it is also possible that, in a state where the cleaning liquid is supplied from the port serving as the waste liquid discharge port 20c to the hollow space 12h of the body 12 of the concentrator 20, the concentrated liquid pipe liquid supplying portion 4p is operated and the connecting pipe liquid supplying portion 9p is operated to supply the cleaning liquid from the cleaning liquid bag SB to the hollow space 12h of the body 12. Even in this case, by controlling the operation of the connecting pipe liquid supplying portion 9p and the concentrated liquid pipe liquid supplying portion 4p by the control unit 106, the cleaning liquid can be filled in the hollow space 12h of the body 12 until the area to be cleaned. In this case, the flow rate of the cleaning liquid supplied from the connecting pipe liquid supplying portion 9p is made greater than the flow rate sucked out from the concentrated liquid pipe liquid supplying portion 4p until the cleaning liquid is filled in the area to be cleaned. And, as long as the cleaning liquid is filled in the area to be cleaned, the control unit 106 controls the flow rate sucked out from the concentrated liquid pipe liquid supplying portion 4p to be slightly greater than the flow rate of the cleaning liquid supplied from the connecting pipe liquid supplying portion 9p.

[0323] In addition, although the cleaning liquid is filled to the area to be cleaned, the area to be cleaned is not necessarily limited to the area where the concentrated liquid exists in the filtration and concentration operation, and may be an area smaller than the area (for example, until Fig. 20 The height of H3 may be greater than the height of H3, or may be a larger area than the height of H3. In addition, the hollow space 12h of the trunk may be filled with cleaning liquid. Furthermore, in the case where only the lower port 20c of the pair of ports 20c and 20c is connected to the waste liquid pipe 5, the hollow space may be filled with cleaning liquid until the cleaning liquid does not leak from the upper port 20c (until Fig. 20 The height of H2).

[0324] In the above example, the following case is described: the axial direction of the hollow fiber membrane of the concentrator 20 is oriented in the up-down direction, and the concentrating operation is performed in a state where the filtrate supply port 20a is located above the concentrate discharge port 20b, and the cleaning operation is performed in the same state. There is a case where the concentrator 20 is configured so that the axial direction of the hollow fiber membrane is oriented in a substantially horizontal direction. In this case, it is desired to perform the cleaning operation in a state where the entire hollow fiber membrane is immersed in the cleaning liquid (or after the cleaning liquid is filled into the hollow space of the trunk so that the entire hollow fiber membrane is immersed in the cleaning liquid) in a manner maintaining this state. Of course, it is also possible to perform the cleaning operation in a manner where only a portion of the hollow fiber membrane is immersed in the cleaning liquid (or after the cleaning liquid is filled into the hollow space of the trunk so that a portion of the hollow fiber membrane is immersed in the cleaning liquid) in a manner maintaining this state, depending on the position of the port 20c. The state in which only a part of the hollow fiber membrane is immersed in the cleaning liquid corresponds to, for example, a state in which the cleaning liquid does not leak from the port 20 c to which the waste liquid pipe 5 is not connected, although the entire hollow fiber membrane is not immersed in the cleaning liquid.

[0325] <Circuit Configuration of Stock Solution Treatment Device 1 of First Embodiment>

[0326] Next, based on Figure 1 The circuit configuration of the raw liquid processing device 1 according to the first embodiment will be described.

[0327] In the following, a case where the raw fluid to be treated is pleural and peritoneal effusion will be described as a representative example.

[0328] In addition, in the following description, the case where each flow path (liquid supply flow path, filtrate supply flow path, concentrated liquid flow path, waste liquid flow path, cleaning liquid supply flow path, cleaning liquid recovery flow path, connecting flow path) described in the claims is formed by a flexible or soft tube (liquid supply tube 2, filtrate supply tube 3, concentrated liquid tube 4, waste liquid tube 5, cleaning liquid supply tube 6, cleaning liquid recovery tube 7, connecting tube 9) is described. However, each flow path may be composed of a tube that is not flexible or soft (for example, a tube made of hard plastic or a steel tube, a vinyl chloride tube, etc.), or all or part of the flow paths may be composed of an integrated circuit obtained by integrally molding by resin molding or the like.

[0329] Furthermore, since the stock liquid processing device 1 of the first embodiment has a pair of roller pumps 110 and 120, the following description is based on the premise that each flow path is formed by a flexible or soft tube and a roller pump is used as the liquid delivery part of each flow path. However, in the stock liquid processing device 1 of the first embodiment, the liquid delivery part is not limited to the roller pump, and various devices that can deliver liquid to the liquid in each flow path can be used. The liquid delivery part can be appropriately selected to match the raw materials of the tubes constituting each flow path and the liquid flowing in the flow path. For example, an infusion pump or a diaphragm pump can also be used as the liquid delivery part. In addition, since the roller pump stops running, it plays a clamping function (a function of closing the flow path so that the liquid cannot flow), so in the following description, no device with a clamping function is provided in the flow path provided with the liquid delivery part. However, when a device that does not exert a clamping function even when the operation is stopped or a device that does not have a clamping function is used as the liquid supply unit, an instrument with a clamping function (such as a clamp or a clip, a solenoid valve, etc.) may be separately provided in the flow path provided with the liquid supply unit, and the instrument with a clamping function may exert a clamping function when the operation of the liquid supply unit is stopped. When a solenoid valve is used, the clamping function may be exerted at the same time as the operation of the liquid supply unit is stopped by the control unit 106 or at a desired timing.

[0330] In addition, since the operation of each liquid supply unit is controlled by the above-mentioned control unit 106, the following description is based on the premise that each liquid supply unit is controlled by the control unit 106.

[0331] <Schematic Configuration of Stock Solution Treatment Device 1 of First Embodiment>

[0332] First, a schematic configuration of a raw liquid processing apparatus 1 according to the first embodiment will be described.

[0333] exist Figure 1 In the figure, reference numeral UB indicates a stock liquid bag for containing a stock liquid, i.e., a stock liquid such as pleural effusion extracted from the chest or abdomen. In addition, reference numeral CB indicates a concentrated liquid bag for containing a concentrated liquid after filtering and concentrating the stock liquid. Furthermore, reference numeral DB indicates a waste liquid bag for containing a waste liquid (i.e., water) separated from the concentrated liquid. Furthermore, reference numeral SB indicates a cleaning liquid bag containing a cleaning liquid such as physiological saline or infusion (extracellular fluid), and reference numeral FB indicates a cleaning liquid recovery bag for recovering the cleaning liquid.

[0334] like Figure 1 As shown, in the raw liquid processing device 1 of the first embodiment, the raw liquid bag UB is connected to the filter 10 via the liquid supply tube 2. The liquid supply tube 2 is a tube for supplying the raw liquid in the raw liquid bag UB to the filter 10. The liquid supply tube 2 is provided with a liquid supply tube liquid supply portion 2p for supplying the liquid in the liquid supply tube 2.

[0335] The filter 10 filters the raw liquid to generate a filtrate. The filter 10 is connected to the concentrator 20 via the filtrate supply pipe 3. The filtrate supply pipe 3 is a pipe for supplying the filtrate generated by the filter 10 to the concentrator 20. The filtrate supply pipe 3 is provided with a flow rate adjustment mechanism 3c such as a clamp or a clip, or an electromagnetic valve, which stops or opens the flow of the liquid in the filtrate supply pipe 3.

[0336] One end of a connection pipe 9 is connected to the portion between the filter 10 and the flow rate adjustment mechanism 3c in the filtrate supply pipe 3. The connection pipe 9 is provided with a connection pipe liquid feeding portion 9p for feeding the liquid in the connection pipe 9.

[0337] In addition, a cleaning liquid bag SB is connected to the filter 10 via a cleaning liquid supply pipe 6. The cleaning liquid supply pipe 6 is a pipe for supplying the cleaning liquid from the cleaning liquid bag SB to the filter 10. The cleaning liquid supply pipe 6 is provided with a flow rate adjustment mechanism 6c such as a clamp or a clip, or a solenoid valve, which stops or opens the flow of the liquid in the cleaning liquid supply pipe 6.

[0338] Furthermore, a cleaning liquid recovery bag FB for recovering the cleaning liquid used to clean the filter 10 is connected to the filter 10 via a cleaning liquid recovery pipe 7. The cleaning liquid recovery pipe 7 is provided with a cleaning liquid recovery pipe feeding portion 7p for feeding the liquid in the cleaning liquid recovery pipe 7.

[0339] In addition, the cleaning liquid recovery pipe 7 may be connected to the filter 10 via the liquid supply pipe 2 or may be directly connected to the filter 10 .

[0340] The concentrator 20 generates a concentrated liquid obtained by concentrating the filtrate. The concentrator 20 is connected to a concentrated liquid bag CB via a concentrated liquid pipe 4. The concentrated liquid pipe 4 is a pipe for supplying the concentrated liquid concentrated by the concentrator 20 to the concentrated liquid bag CB. The concentrated liquid pipe 4 is provided with a concentrated liquid pipe liquid delivery portion 4p for delivering the liquid in the concentrated liquid pipe 4. In addition, a waste liquid pipe liquid delivery portion 5p may be provided in the waste liquid pipe 5 instead of the concentrated liquid pipe liquid delivery portion 4p (see Figure 4 Even in this case, as long as the waste liquid pipe feeding section 5p reduces the amount of waste liquid delivered under the condition that the concentrate pipe feeding section 4p increases the amount of concentrated liquid delivered, or as long as the waste liquid pipe feeding section 5p increases the amount of waste liquid delivered under the condition that the concentrate pipe feeding section 4p reduces the amount of concentrated liquid delivered, the same function as the case where the concentrate pipe feeding section 4p is provided in the concentrate pipe 4 is achieved. The case where the concentrate pipe feeding section 4p is provided in the concentrate pipe 4 is described below.

[0341] Furthermore, a waste liquid bag DB is connected to the concentrator 20 via a waste liquid pipe 5. The waste liquid pipe 5 is a pipe for supplying the waste liquid (water) separated from the concentrated liquid by the concentrator 20 to the waste liquid bag DB.

[0342] Due to the above-described configuration, in the raw liquid processing apparatus 1 of the first embodiment, when the raw liquid is supplied from the raw liquid bag UB to the filter 10 via the liquid supply pipe 2, the raw liquid can be filtered by the filter 10 to generate a filtrate. Then, when the generated filtrate is supplied to the concentrator 20 via the filtrate supply pipe 3, a concentrated liquid can be generated by the concentrator 20, and the concentrated liquid can be recovered to the concentrated liquid bag CB via the concentrated liquid pipe 4.

[0343] On the other hand, if the cleaning liquid is supplied from the cleaning liquid bag SB connected to the cleaning liquid supply pipe 6 to the filter 10, the filter 10 can be cleaned with the cleaning liquid. In addition, if the cleaning liquid bag SB is connected to the concentrated liquid pipe 4 instead of the concentrated liquid bag CB, the concentrator 20 can be cleaned with the cleaning liquid (see Figure 2 ).

[0344] When the cleaning liquid bag SB is connected to the concentrated liquid tube 4 instead of the concentrated liquid bag CB, the cleaning liquid used to clean the concentrator 20 can be supplied to the filter 10 through the filtrate supply tube 3. That is, the concentrator 20 and the filter 10 can be cleaned simultaneously.

[0345] Hereinafter, the operation of the raw liquid processing apparatus 1 according to the first embodiment will be described.

[0346] <Preparation for cleaning>

[0347] like Figure 2 As shown, in the preparatory cleaning operation of the raw liquid treatment device 1 of the first embodiment, the cleaning liquid bag SB is connected to the other end of the concentrated liquid tube 4 instead of the concentrated liquid bag CB, and the cleaning liquid recovery bag FB is connected to the other end of the waste liquid tube 5 instead of the waste liquid bag DB. In addition, the other end of the waste liquid tube 5 may remain connected to the waste liquid bag DB, or the other end of the waste liquid tube 5 may be simply arranged in a bucket or the like.

[0348] In addition, the cleaning liquid recovery bag FB is also connected to the other end of the liquid supply tube 2 instead of the original liquid bag UB. In addition, the waste liquid bag DB can be connected to the other end of the liquid supply tube 2, and the other end of the liquid supply tube 2 can also be simply configured in a bucket or the like.

[0349] And, the cleaning liquid recovery bag FB is also connected to the other end of the connection tube 9. In addition, the waste liquid bag DB may also be connected to the other end of the connection tube 9, and the other end of the connection tube 9 may also be simply arranged in a bucket or the like.

[0350] Next, the flow rate regulating mechanism 3 c and the flow rate regulating mechanism 6 c are opened to allow the cleaning liquid to flow through the filtrate supply pipe 3 and the cleaning liquid supply pipe 6 .

[0351] In the above state, the concentrated liquid pipe liquid feeding part 4p is operated so that the cleaning liquid flows from the cleaning liquid bag SB connected to the concentrated liquid pipe 4 to the concentrator 20, and the connecting pipe liquid feeding part 9p is operated so that the cleaning liquid flows from the concentrator 20 (i.e., the filtrate supply pipe 3) to the cleaning liquid recovery bag FB connected to the connecting pipe 9. Thus, the cleaning liquid is supplied to the concentrator 20 from the cleaning liquid bag SB connected to the concentrated liquid pipe 4 through the concentrated liquid pipe 4. After passing through the concentrator 20, the supplied cleaning liquid is recovered to the cleaning liquid recovery bag FB connected to the connecting pipe 9 through the filtrate supply pipe 3 and the connecting pipe 9. In addition, a part of the cleaning liquid is recovered to the cleaning liquid recovery bag FB connected to the other end of the waste liquid pipe 5 through the waste liquid pipe 5.

[0352] Furthermore, the connection pipe liquid feeding section 9p is operated so that the cleaning liquid flows from the concentrator 20 to the cleaning liquid recovery bag FB connected to the connection pipe 9, and the liquid supply pipe liquid feeding section 2p is operated so that the cleaning liquid flows from the filter 10 to the cleaning liquid recovery bag FB connected to the liquid supply pipe 2. Thus, the cleaning liquid is supplied to the filter 10 from the cleaning liquid bag SB connected to the cleaning liquid supply pipe 6 through the cleaning liquid supply pipe 6. After the supplied cleaning liquid passes through the filter 10, a part of it is recovered to the cleaning liquid recovery bag FB connected to the connection pipe 9 through the filtrate supply pipe 3 and the connection pipe 9, and a part of it is recovered to the cleaning liquid recovery bag FB connected to the liquid supply pipe 2 through the liquid supply pipe 2. Furthermore, by operating the cleaning liquid recovery pipe liquid feeding section 7p, a part of the cleaning liquid supplied to the filter 10 can also flow to the cleaning liquid recovery pipe 7.

[0353] Thus, the cleaning liquid can flow through the filter 10, the concentrator 20, and all the tubes, and thus the entire raw liquid treatment device 1 of the first embodiment can be cleaned.

[0354] In addition, Figure 2 In the embodiment, the cleaning liquid is sucked out from the filter 10 by operating the liquid supply pipe liquid supply part 2p and the cleaning liquid recovery pipe liquid supply part 7p, and a flow of the cleaning liquid is generated in the filter 10, thereby cleaning the inside of the filter 10. However, the cleaning liquid may be pushed into the filter 10, and a flow of the cleaning liquid may be generated in the filter 10, thereby cleaning the inside of the filter 10.

[0355] For example, in Figure 2In the embodiment, a cleaning liquid supply pipe liquid delivery portion 6p is provided in the cleaning liquid supply pipe 6 instead of the flow adjustment mechanism 6c, and a flow adjustment mechanism 7c is provided in the cleaning liquid recovery pipe 7 instead of the cleaning liquid recovery pipe liquid delivery portion 7p. Then, the cleaning liquid recovery pipe 7 is opened by the flow adjustment mechanism 7c, and the cleaning liquid supply pipe liquid delivery portion 6p is operated in such a manner that the cleaning liquid flows from the cleaning liquid bag SB toward the filter 10 in the cleaning liquid supply pipe 6. Thus, the cleaning liquid can be pushed into the filter 10, and a flow of the cleaning liquid is generated in the filter 10, so that the inside of the filter 10 can also be cleaned by the cleaning liquid. In this case, the liquid supply pipe liquid delivery portion 2p of the liquid supply pipe 2 can also be operated to suck the cleaning liquid out of the filter 10 so that the cleaning liquid flows in the liquid supply pipe 2. In addition, the liquid supply pipe liquid delivery portion 2p can also be not operated, and only the cleaning liquid can flow in the cleaning liquid recovery pipe 7.

[0356] <Filtration and concentration work>

[0357] When the cleaning operation is completed, the filtration and concentration operation is performed.

[0358] like Figure 1 As shown, in the filtration and concentration operation of the raw liquid treatment device 1 of the first embodiment, from the state of preparing for the cleaning operation (refer to Figure 2 ) Connect the concentrate bag CB to the concentrate pipe 4 instead of the cleaning liquid bag SB, and connect the waste liquid bag DB to the waste liquid pipe 5 instead of the cleaning liquid recovery bag FB.

[0359] On the other hand, the liquid supply tube 2 is connected to a raw liquid bag UB instead of the cleaning liquid recovery bag FB.

[0360] Furthermore, the flow rate adjustment mechanism 3c maintains the state in which the liquid can flow in the filtrate supply pipe 3, while the flow rate adjustment mechanism 6c is closed so that the liquid cannot flow in the cleaning liquid supply pipe 6. In addition, the cleaning liquid recovery pipe liquid delivery portion 7p and the connecting pipe liquid delivery portion 9p are not operated and function as a clamp.

[0361] In the above state, the liquid supply tube delivery part 2p is operated in such a way that the raw liquid flows from the raw liquid bag UB connected to the liquid supply tube 2 to the filter 10, and the concentrated liquid tube delivery part 4p is operated in such a way that the concentrated liquid flows from the concentrator 20 to the concentrated liquid bag CB connected to the concentrated liquid tube 4.

[0362] Thus, the stock solution is supplied from the stock solution bag UB to the filter 10 through the liquid supply pipe 2. The supplied stock solution is filtered by the filter 10, and the generated filtrate is supplied to the concentrator 20 through the filtrate supply pipe 3. Then, the filtrate supplied to the concentrator 20 is concentrated by the concentrator 20, and the generated concentrated liquid is recovered to the concentrated liquid bag CB through the concentrated liquid pipe 4. On the other hand, the water separated from the concentrated liquid is recovered to the waste liquid bag DB through the waste liquid pipe 5.

[0363] <About Filtration and Concentration Operation>

[0364] Here, in the filtering and concentrating operation, the operation of the liquid supply pipe liquid supply part 2p and the liquid supply pipe liquid supply part 4p of the concentrate is controlled so that the concentration ratio reaches a predetermined range. However, it is also possible to control the operation of the liquid supply pipe liquid supply part 2p and the liquid supply pipe liquid supply part 4p of the concentrate by utilizing the differential pressure between the filter membranes and the differential pressure between the concentrator membranes as described below, that is, to control the flow rate flowing in the liquid supply pipe liquid supply part 2p and the liquid supply pipe liquid supply part 4p of the concentrate. In this way, the capacity of the filter 10 and the concentrator 20 can be effectively utilized to perform filtering and concentrating, thereby shortening the time until the concentrated liquid is generated, and improving the efficiency of the concentration operation.

[0365] Hereinafter, an operation of performing filtration and concentration by controlling the operation of the liquid feed pipe liquid supply section 2p and the concentrate pipe liquid supply section 4p using the filter inter-membrane pressure difference and the concentrator inter-membrane pressure difference to perform filtration and concentration will be described.

[0366] In addition, the filter membrane differential pressure refers to the differential pressure between the liquid supply side and the liquid discharge side of the filter component (hollow fiber membrane, etc.) of the filter 10. For example, if the filter component of the filter 10 is a hollow fiber membrane 16, the difference between the pressure in the through-flow path 16h of the hollow fiber membrane 16 and the pressure in the hollow space 12h of the trunk 12 is equivalent to the filter membrane differential pressure.

[0367] The differential pressure between the concentrator membranes refers to the differential pressure between the liquid feed side and the liquid discharge side of the water separation component (hollow fiber membrane, etc.) of the concentrator 20. For example, if the filtration component of the concentrator 20 is a hollow fiber membrane, the difference between the pressure in the through-flow path of the hollow fiber membrane and the pressure in the hollow space of the trunk portion corresponds to the differential pressure between the concentrator membranes.

[0368] In addition, the differential pressure between the filter membranes and the differential pressure between the concentrator membranes can be calculated by measuring the pressure inside the pipes connected to the filter 10 and the concentrator 20. For example, if a pressure gauge is installed in the liquid supply pipe 2 and the filtrate supply pipe 3 in advance and the signal is supplied to the control unit 106, the control unit 106 can calculate the differential pressure between the filter membranes. Figure 1 As shown, even if a pressure gauge is provided at the port 11c (or the tube connected to the port 11c) to which the filtrate supply pipe 3 is not connected, the control unit 106 can calculate the differential pressure between the filter membranes. In addition, as long as a pressure gauge is provided in advance at the filtrate supply pipe 3 and the waste liquid pipe 5, and the signal is supplied to the control unit 106, the control unit 106 can calculate the differential pressure between the concentrator membranes. In addition, in the case where there is a port 20c to which the waste liquid pipe 5 is not connected, even if a pressure gauge is provided at the port 20c (or the tube connected to the port 20c), the control unit 106 can calculate the differential pressure between the concentrator membranes.

[0369] In addition, in the filter 10 and the concentrator 20, as long as either the liquid supply side or the liquid discharge side is in a state close to being open to the atmosphere, the control unit 106 can calculate the filter membrane differential pressure and the concentrator membrane differential pressure even if only the pressure inside the tube connected to the side that is not open to the atmosphere on the liquid supply side and the liquid discharge side is measured. In other words, the control unit 106 can also control the operation of the liquid supply unit by using only the pressure inside the tube connected to the side that is not open to the atmosphere instead of the filter membrane differential pressure and the concentrator membrane differential pressure. For example, as long as the tube connected to the filter 10 and the concentrator 20 is connected to the bag and the tube is not closed by the liquid supply unit or the flow adjustment mechanism, it can be considered that the tube is in a state close to being open to the atmosphere. If it is Figure 1 In the state of, the liquid supply tube 2 connected to the original liquid bag UB among the tubes 2 and 3 connected to the filter 10 can also be regarded as open to the atmosphere. In addition, the waste liquid tube 5 connected to the waste liquid bag DB among the tubes 3 and 5 connected to the concentrator 20 can also be regarded as open to the atmosphere. Figure 1 , the control unit 106 can also control the operation of the liquid delivery unit using only the internal pressure of the filter supply pipe 3.

[0370] In addition, the flow rate of the liquid flowing in the liquid supply pipe 2 or the filtrate supply pipe 3 can also be estimated based on the operation of the liquid supply pipe liquid supply part 2p and the concentrate pipe liquid supply part 4p, or a flow meter can be set in the liquid supply pipe 2 or the liquid supply pipe liquid supply part 2p, the concentrate pipe 4 or the concentrate pipe liquid supply part 4p to directly measure the flow rate.

[0371] <Description of Filtration and Concentration Operation Using the Differential Pressure Between Filter and Concentrator Membranes>

[0372] In the case of a filtration and concentration operation using the differential pressure between the filter membranes and the differential pressure between the concentrator membranes, the allowable differential pressure is set in advance. That is, the differential pressure (allowable differential pressure) that the filter 10 and the concentrator 20 can allow is set according to the filter 10 and the concentrator 20, respectively. The allowable differential pressure may have a prescribed range or may be set to a specific value. In addition, the following description is based on the case where the allowable differential pressure has a prescribed range as a representative.

[0373] In addition, in the case of a filtration and concentration operation utilizing the differential pressure between the filter membrane and the differential pressure between the concentrator membrane, it is desirable to pre-set the allowable flow rate. That is, it is desirable to set the flow rate (allowable flow rate) that the raw liquid in the liquid supply pipe 2 can allow. The allowable flow rate can have a specified amplitude or be set to a specific value. The allowable flow rate does not necessarily have to be set. However, if the flow rate of the raw liquid in the liquid supply pipe 2 is too small, the time consumed for filtration and concentration becomes too long. Therefore, in order to prevent the processing time of the raw liquid from being prolonged, it is desirable to pre-set the allowable flow rate.

[0374] Furthermore, in the case of a filtration and concentration operation using the differential pressure between the filter membrane and the differential pressure between the concentrator membrane, it is desirable to pre-set the allowable concentration ratio. That is, it is desirable to set the ratio of the flow rate of the stock solution in the liquid supply pipe 2 to the flow rate of the concentrated liquid flowing in the concentrated liquid pipe 4 (the allowable concentration ratio). The allowable concentration ratio may have a specified amplitude or may be set to a specific value. The allowable concentration ratio does not necessarily have to be set. However, if the ratio of the flow rate of the stock solution in the liquid supply pipe 2 to the flow rate of the concentrated liquid flowing in the concentrated liquid pipe 4, that is, the concentration ratio, is too low (that is, the flow rate of the concentrated liquid becomes too large), the concentration efficiency deteriorates. Moreover, since the amount of concentrated liquid increases and a large amount of filtered concentrated liquid is intravenously infused again, there is a risk of causing increased blood pressure, worsening heart failure and respiratory failure, etc. Therefore, when the amount of concentrated liquid becomes excessive, additional re-concentration processing is required, and the re-concentration processing takes time. In the case of re-concentrating the concentrated liquid, since the re-concentration processing takes time, the total time used to process the stock liquid becomes longer. Therefore, in order to prevent the concentration ratio from being excessively reduced, it is desirable to set the allowable concentration ratio in advance.

[0375] At the start of filtration and concentration, the liquid supply pipe liquid supply section 2p is operated to increase the amount of raw liquid supplied to the filter 10. At this time, the concentrate pipe liquid supply section 4p is operated in a manner that matches the flow rate of the raw liquid in the liquid supply pipe 2 so that the concentrated liquid reaches a predetermined concentration ratio. For example, in the case of generating a concentrated liquid having a concentration ratio of 10 times, the operation of the concentrate pipe liquid supply section 4p can be adjusted so that the flow rate of the concentrated liquid flowing in the concentrate pipe 4 reaches 1 / 10 of the flow rate of the raw liquid flowing in the liquid supply pipe 2. In addition, the operation of the concentrate pipe liquid supply section 4p can be adjusted so that the differential pressure between the concentrator membranes becomes a set value within the allowable differential pressure (or is maintained within the allowable differential pressure) instead of the concentration ratio of the concentrated liquid, or the differential pressure between the concentrator membranes becomes a set value within the allowable differential pressure (or is maintained within the allowable differential pressure) while maintaining the concentrated liquid at a predetermined concentration ratio. In addition, while increasing the amount of raw liquid supplied to the filter 10, the operation of the concentrate pipe liquid supply section 4p is controlled so as to reach any of the above-mentioned states.

[0376] As the filtration and concentration progresses, the filter 10 and the concentrator 20 gradually become clogged. As a result, the filter membrane differential pressure and the concentrator membrane differential pressure increase. However, the liquid supply pipe liquid supply section 2p is operated to increase the liquid supply amount of the raw liquid to the filter 10 until the filter membrane differential pressure and the concentrator membrane differential pressure are within the allowable differential pressure.

[0377] <First Method>

[0378] The increase in the amount of the raw liquid delivered to the filter 10 continues until the differential pressure between the filter membranes is within the allowable differential pressure of the filter 10. If the differential pressure between the filter membranes is within the allowable differential pressure of the filter 10, the liquid supply pipe delivery portion 2p is controlled to maintain the flow rate of the raw liquid in the liquid supply pipe 2 at a flow rate in which the differential pressure between the filter membranes reaches the allowable differential pressure of the filter 10. On the other hand, the concentrated liquid pipe delivery portion 4p is operated to adjust the flow rate of the concentrated liquid flowing in the concentrated liquid pipe 4.

[0379] Here, when the differential pressure between the filter membranes is within the allowable differential pressure of the filter 10, the operation of the liquid supply pipe liquid supply part 2p is controlled in such a manner as to maintain the liquid supply amount of the filtrate to the concentrator 20, in other words, to maintain the liquid supply amount of the raw liquid to the filter 10. Thus, the filtering by the filter 10 and the concentration by the concentrator 20 can be maintained in a predetermined state. In addition, if the liquid supply amount of the raw liquid to the filter 10 is increased or decreased according to the value of the differential pressure between the filter membranes, the differential pressure between the filter membranes can be maintained within the allowable differential pressure of the filter 10, while increasing the liquid supply amount of the raw liquid to the filter 10. That is, there is a possibility that the efficiency of the filtration and concentration operation can be improved. In particular, if the differential pressure between the filter membranes is maintained at the maximum allowable differential pressure PM of the filter 10, the liquid supply amount of the raw liquid to the filter 10 can also be increased to the maximum limit, so that the effect of shortening the time of the filtration operation can be further improved.

[0380] On the other hand, if the differential pressure between the filter membranes becomes larger than the allowable differential pressure (maximum allowable differential pressure PM) of the filter 10, the operation of the liquid supply pipe liquid supply part 2p is controlled so that the amount of liquid supplied to the filter 10 is reduced. In the case where the hollow fiber membrane 16 or the like is blocked even if the amount of liquid supplied to the filter 10 is constant, there is a possibility that the differential pressure between the filter membranes becomes larger and the filtration cannot be continued. However, if the amount of liquid supplied to the filter 10 is reduced, the differential pressure between the filter membranes can be reduced, so the filtration operation can be continued even if the filter 10 is blocked. Moreover, there is also the possibility that the blockage of the hollow fiber membrane 16 or the like can be slightly reduced due to the reduction in the amount of liquid supplied to the filter 10, so it is possible to make it easier to continue the filtration operation and shorten the time of the filtration operation. In particular, when the differential pressure between the filter membranes becomes greater than the maximum allowable differential pressure PM of the filter 10, as long as the liquid supply to the filter 10 is temporarily stopped and the supply is started again after a certain period of time, it is possible to improve the effect of reducing the blockage of the hollow fiber membrane or the like.

[0381] In addition, when the differential pressure between the filter membranes becomes less than the minimum allowable differential pressure PL of the filter 10 by reducing the amount of liquid delivered to the filter 10, the operation of the liquid delivery part 2p of the liquid supply pipe is controlled so that the amount of liquid delivered to the filter 10 is increased. As a result, since the filtration amount of the filter 10 can be increased, there is a possibility that the time of the filtration operation can be shortened. In addition, if the amount of liquid delivered to the filter 10 is increased until the differential pressure between the filter membranes is within the allowable differential pressure of the filter 10, especially the maximum allowable differential pressure PM, the filtration capacity of the filter 10 can be effectively used, so the effect of shortening the time of the filtration operation can be further improved.

[0382] In addition, when the differential pressure between the filter membranes becomes greater than the maximum allowable differential pressure PM of the filter 10, the amount of liquid delivered to the filter 10 may be reduced, the amount of liquid delivered may be reduced gradually, or the amount of liquid delivered may be reduced in a step-like manner. Fig.24 In the case of PM), the feeding of the raw liquid to the filter 10 may be stopped for a certain period of time and then the feeding of the raw liquid to the filter 10 may be started (see Fig.24 ). In this case, it is sufficient to adjust the amount of the raw liquid delivered to the filter 10 while confirming the differential pressure between the filter membranes. Fig.24 As shown in mode 1, when the supply of the raw liquid to the filter 10 is stopped for a certain period of time and then the supply of the raw liquid to the filter 10 is started, the supply is first started at a flow rate of about 1 / 2 of the maximum allowable flow rate LM and the differential pressure between the filter membranes at this time is confirmed. If the differential pressure between the filter membranes is less than the minimum allowable differential pressure PL ( Fig.24 PL), then increase the flow rate by about 1 / 2 of the difference between the current flow rate and the maximum allowable flow rate LM and confirm the differential pressure between the filter membranes at this time. If the differential pressure between the filter membranes is still less than the minimum allowable differential pressure PL in this state, further increase the flow rate by about 1 / 2 of the difference between the current flow rate and the maximum allowable flow rate LM and confirm the differential pressure between the filter membranes at this time. Repeat this operation, and if the differential pressure between the filter membranes is above the minimum allowable differential pressure PL of the filter 10 and below the maximum allowable differential pressure PM (or if the maximum allowable differential pressure PM is reached), stop increasing the flow rate. In addition, even if the differential pressure between the filter membranes is within the allowable differential pressure of the filter 10, if the maximum allowable flow rate LM is not reached, the amount of raw liquid delivered to the filter 10 can be increased in the same way while confirming the differential pressure between the filter membranes until the maximum allowable flow rate LM is reached.

[0383] When the flow rate of the raw liquid to the filter 10 is increased when the differential pressure between the filter membranes becomes smaller than the minimum allowable differential pressure PL of the filter 10, the flow rate of the raw liquid may be gradually increased. For example, the flow rate may be increased by the same method as the above-mentioned flow rate increasing method, i.e., the flow rate increasing method starting from the state where the flow rate of the raw liquid to the filter 10 is stopped for a certain period of time.

[0384] In addition, when the differential pressure between the filter membranes is maintained within the allowable differential pressure of the filter 10, it is sufficient to maintain the amount of raw liquid delivered to the filter 10. However, when the flow rate is less than the maximum allowable flow rate LM, the amount of raw liquid delivered to the filter 10 can also be increased until the maximum allowable flow rate LM is reached.

[0385] Even if the differential pressure between the filter membranes reaches or exceeds the minimum allowable differential pressure PL of the filter 10, if the amount of raw liquid delivered to the filter 10 does not reach the minimum allowable flow rate LL ( Fig.24 In mode 3), it can also be determined that clogging of the hollow fiber membrane 16 or the like has occurred, so the filtration and concentration operation is terminated and the operation is transferred to the cleaning operation.

[0386] In addition, when the differential pressure between the filter membranes is within the allowable differential pressure of the filter 10 and the flow rate of the raw liquid in the liquid supply pipe 2 is maintained at a flow rate at which the differential pressure between the filter membranes reaches the allowable differential pressure of the filter 10, the concentrated liquid pipe liquid supply section 4p can be controlled in the following manner based on the differential pressure between the concentrator membranes.

[0387] <Step 1>

[0388] First, when the differential pressure between the concentrator membranes is less than the minimum allowable differential pressure of the concentrator 20, the concentrated liquid pipe feeder 4p is operated to reduce the amount of concentrated liquid delivered to the concentrated liquid bag CB. That is, the operation of the concentrated liquid pipe feeder 4p is controlled to increase the concentration of the concentrated liquid.

[0389] <Step 2>

[0390] Then, the amount of concentrate delivered to the concentrate bag CB is reduced until the differential pressure between the concentrator membranes is within the allowable differential pressure of the concentrator 20. If the differential pressure between the concentrator membranes is within the allowable differential pressure of the concentrator 20, the concentrate pipe delivery section 4p is controlled so that the flow rate of the concentrate in the concentrate pipe 4 is maintained at a flow rate at which the differential pressure between the concentrator membranes becomes within the allowable differential pressure of the concentrator 20.

[0391] <Step 3>

[0392] After a while, if the differential pressure between the concentrator membranes becomes greater than the maximum allowable differential pressure of the concentrator 20 due to clogging of the concentrator 20 or the like, the concentrated liquid pipe delivery portion 4p is controlled so that the amount of concentrated liquid delivered to the concentrated liquid bag CB is increased. In addition, although the concentration ratio is reduced as the amount of concentrated liquid delivered increases, the operation of the concentrated liquid pipe delivery portion 4p is controlled so that the concentration ratio is reduced (the concentration of the concentrated liquid is reduced) while satisfying the allowable concentration ratio.

[0393] When the delivery rate of the concentrated liquid is increased to maintain the differential pressure between the concentrator membranes within the allowable differential pressure range and the concentration ratio becomes smaller than the allowable concentration ratio, the following method (second method) can be used to cope with the situation.

[0394] Since the differential pressure between the concentrator membranes decreases if the amount of concentrate delivered to the concentrate bag CB increases, when the differential pressure between the concentrator membranes becomes lower than the minimum allowable differential pressure of the concentrator 20, the concentrate pipe delivery part 4p is operated again to reduce the amount of concentrate delivered to the concentrate bag CB.

[0395] That is, the above steps 1 to 3 are repeated while the differential pressure between the filter membranes is within the allowable differential pressure of the filter 10. If this method is adopted, it is possible to ensure the maximum filtration flow rate (i.e., the above-mentioned maximum allowable flow rate LM) and the maximum concentration ratio corresponding to the membrane area and clogging state of the filter membranes of the filter 10 and the concentrator 20, or the state of the stock solution (the concentration of the substance causing the clogging of the filter and the concentrator, or the concentration of the recovered useful substance, the viscosity of the liquid, etc.), which cannot be achieved when the amount of liquid fed to the filter 10 and the concentrated liquid bag CB is constant. That is, by improving the filtration efficiency and the concentration efficiency, the time for generating the concentrated liquid from the stock solution can be shortened, and the re-concentration operation can be avoided or the time consumed for the re-concentration operation can be shortened.

[0396] Furthermore, if the operation is performed as described above, the cleaning liquid filled in the filter 10, the concentrator 20, and the circuit at the start of filtration and concentration, and the cleaning liquid in the filter 10 and the circuit immediately after the filter 10 is cleaned can be removed in a short time as waste liquid of the concentrator 20. That is, dilution of the concentrated liquid by the cleaning liquid at the start and immediately after the filter is cleaned can be effectively prevented.

[0397] In addition, the above method (first method) is intended to be adopted when the maximum allowable differential pressure PM of the filter membrane differential pressure is greater than the maximum allowable differential pressure of the concentrator membrane differential pressure, but is not limited to this condition. It can also be adopted when the maximum allowable differential pressure PM of the filter membrane differential pressure is less than the maximum allowable differential pressure of the concentrator membrane differential pressure.

[0398] In addition, when the differential pressure between the filter membranes is greater than the maximum allowable differential pressure PM, when the differential pressure between the filter membranes is less than the minimum allowable differential pressure PL, and when the amount of raw liquid delivered to the filter 10 is constant and has nothing to do with the differential pressure between the filter membranes, the above steps 1 to 3 can be repeatedly performed to adjust the amount of concentrated liquid delivered to the concentrator 20.

[0399] <Second Method>

[0400] In the first method, the flow rate of the concentrated liquid in the concentrated liquid pipe 4 is adjusted based on the concentrator intermembrane pressure difference. The flow rate of the raw liquid in the liquid feed pipe 2 can also be adjusted based on the concentrator intermembrane pressure difference as described below.

[0401] In addition, the following description will be made of a case where the flow rate of the raw liquid in the liquid feed pipe 2 is adjusted based on the differential pressure between the concentrator membranes, but steps 1 to 3 of the first method may be performed together with the flow rate adjustment of the raw liquid in the liquid feed pipe 2. That is, the flow rate of the concentrated liquid in the concentrated liquid pipe, i.e., the concentration ratio of the concentrated liquid, may be adjusted while adjusting the flow rate of the raw liquid in the liquid feed pipe 2 based on the differential pressure between the concentrator membranes.

[0402] <Step 1>

[0403] First, when the differential pressure between the concentrator membranes is less than the minimum allowable differential pressure of the concentrator 20, the liquid supply pipe liquid supply section 2p is operated to increase the amount of liquid supplied to the filter 10. That is, the operation of the liquid supply pipe liquid supply section 2p is controlled so that the amount of filtrate produced to the concentrator 20 increases. Alternatively, the concentrated liquid pipe liquid supply section 4p may be operated so that the amount of liquid supplied to the filter 10 increases and the concentration of the concentrated liquid increases.

[0404] <Step 2>

[0405] Then, the amount of filtrate to be delivered to the concentrator 20 (in other words, the amount of raw liquid delivered to the filter 10) is increased until the differential pressure between the membranes of the concentrator is within the allowable differential pressure of the concentrator 20 (above the minimum allowable differential pressure and below the maximum allowable differential pressure). Furthermore, if the differential pressure between the membranes of the concentrator is within the allowable differential pressure of the concentrator 20, the operation of the liquid supply pipe delivery section 2p is controlled so that the flow rate of the raw liquid in the liquid supply pipe 2 is maintained at a flow rate in a state where the differential pressure between the membranes of the concentrator becomes within the allowable differential pressure of the concentrator 20. In addition, in this case, the flow rate of the raw liquid in the liquid supply pipe 2 deviates from the flow rate in a state where the differential pressure between the membranes of the filter is within the allowable differential pressure of the filter 10, but it is desirable to maintain the flow rate of the raw liquid within the allowable flow rate (above the minimum allowable flow rate and below the maximum allowable flow rate). In addition, the liquid supply section 4p of the concentrate pipe may be operated so that the flow rate of the concentrate in the concentrate pipe 4 is maintained at a flow rate in a state where the differential pressure between the membranes of the concentrator is within the allowable differential pressure of the concentrator 20.

[0406] <Step 3>

[0407] After a while, if the differential pressure between the membranes of the concentrator becomes greater than the maximum allowable differential pressure of the concentrator 20 due to clogging of the concentrator 20, etc., the operation of the liquid supply pipe liquid supply section 2p is controlled to reduce the flow rate of the raw liquid in the liquid supply pipe 2. That is, the operation of the liquid supply pipe liquid supply section 2p is controlled to reduce the amount of filtrate delivered to the concentrator 20. In addition, in this case, the flow rate of the raw liquid in the liquid supply pipe 2 also deviates from the flow rate in the state where the differential pressure between the filter membranes is within the allowable differential pressure of the filter 10, but it is expected that the flow rate of the raw liquid is maintained within the allowable flow rate. In addition, the liquid supply section 4p of the concentrate pipe can also be operated to reduce the concentration ratio while satisfying the allowable concentration ratio (so that the concentration of the concentrate becomes lower).

[0408] If the flow rate of the raw liquid in the liquid feed pipe 2 decreases, the differential pressure between the concentrator membranes decreases. Therefore, if the differential pressure between the concentrator membranes becomes lower than the minimum allowable differential pressure of the concentrator 20, the liquid feed pipe liquid delivery part 2p is operated again to increase the flow rate of the raw liquid in the liquid feed pipe 2.

[0409] That is, the above steps 1 to 3 are repeated while the differential pressure between the filter membranes is within the allowable differential pressure of the filter 10. If this method is adopted, it is possible to ensure the maximum filtration flow rate (i.e., the above-mentioned maximum allowable flow rate LM) and the maximum concentration ratio corresponding to the membrane area and clogging state of the filter membranes of the filter 10 and the concentrator 20, or the state of the stock solution (the concentration of the substance causing the clogging of the filter and the concentrator, or the concentration of the recovered useful substance, the viscosity of the liquid, etc.), which cannot be achieved when the amount of liquid fed to the filter 10 and the concentrated liquid bag CB is constant. That is, by improving the filtration efficiency and the concentration efficiency, the time for generating the concentrated liquid from the stock solution can be shortened, and the re-concentration operation can be avoided or the time consumed for the re-concentration operation can be shortened.

[0410] Furthermore, if the operation is performed as described above, the cleaning liquid filled in the filter 10, the concentrator 20, and the circuit at the start of filtration and concentration, and the cleaning liquid in the filter 10 and the circuit immediately after the filter 10 is cleaned can be removed in a short time as waste liquid of the concentrator 20. That is, dilution of the concentrated liquid by the cleaning liquid at the start and immediately after the filter is cleaned can be effectively prevented.

[0411] In addition, although the above method (second method) is intended to be adopted when the maximum allowable differential pressure between the concentrator membranes is greater than the maximum allowable differential pressure PM between the filter membranes, it is not limited to this condition and can also be adopted when the maximum allowable differential pressure between the concentrator membranes is less than the maximum allowable differential pressure PM between the filter membranes.

[0412] In addition, when the differential pressure between the filter membranes is greater than the maximum allowable differential pressure PM, when the differential pressure between the filter membranes is less than the minimum allowable differential pressure PL, and when the amount of raw liquid delivered to the filter 10 is constant and has nothing to do with the differential pressure between the filter membranes, the above steps 1 to 3 can be repeatedly performed to adjust the amount of concentrated liquid delivered to the concentrator 20.

[0413] <About filter cleaning>

[0414] If the filtering and concentrating operation as described above is performed, the differential pressure between the filter membranes becomes greater than the maximum allowable differential pressure PM of the filter 10 due to the blockage of the filter 10. In this case, if the operation of the liquid supply pipe liquid delivery section 2p is controlled to reduce the flow rate of the raw liquid in the liquid supply pipe 2, the differential pressure between the filter membranes can be made less than the maximum allowable differential pressure PM of the filter 10, and the differential pressure between the filter membranes can be maintained within the allowable differential pressure (above the minimum allowable differential pressure PL and below the maximum allowable differential pressure PM). However, if the blockage of the filter 10 becomes serious, the flow rate of the raw liquid in the liquid supply pipe 2 may be reduced in order to maintain the differential pressure between the filter membranes within the allowable differential pressure of the filter 10, and the flow rate of the raw liquid in the liquid supply pipe 2 may become less than the minimum allowable flow rate LL. If the above state is reached, the cleaning operation of the filter 10 is performed in the middle of the filtering and concentrating operation of the raw liquid treatment device 1 of the first embodiment.

[0415] like Fig.21 As shown, during the cleaning operation of the filter 10, the flow rate adjustment mechanism 3c is closed so that the liquid cannot flow in the filtrate supply pipe 3. In addition, the operation of the liquid supply pipe liquid delivery part 2p is stopped to function as a clamp. On the other hand, the flow rate adjustment mechanism 6c can be opened to allow the liquid to flow in the cleaning liquid supply pipe 6.

[0416] In the above state, the cleaning liquid recovery pipe liquid feeding portion 7p is operated so that the liquid flows from the cleaning liquid bag SB connected to the cleaning liquid supply pipe 6 through the filter 10 to the cleaning liquid recovery bag FB connected to the cleaning liquid recovery pipe 7. As a result, the cleaning liquid can flow in the flow path of the filter 10 through which the raw liquid flows in the direction opposite to the direction in which the raw liquid flows during filtration and concentration, so that the inside of the flow path of the filter 10 through which the raw liquid flows can be cleaned.

[0417] In addition to the above state, if the connecting tube liquid feeding part 9p is operated so that the cleaning liquid flows from the cleaning liquid bag SB connected to the connecting tube 9 to the filter 10, the cleaning liquid is also supplied from the cleaning liquid bag SB connected to the connecting tube 9 to the filter 10. Thus, since the cleaning liquid passes through the filter component in the direction opposite to the direction in which the filtrate passes through the filter component, clogging of the filter component can be eliminated. In this case, since the cleaning liquid is supplied to the filter 10 from both the cleaning liquid bag SB connected to the cleaning liquid supply tube 6 and the cleaning liquid bag SB connected to the connecting tube 9, the operation of the cleaning liquid recovery tube liquid feeding part 7p and the connecting tube liquid feeding part 9p is adjusted so that the flow rate of the cleaning liquid flowing in the cleaning liquid recovery tube 7 through the cleaning liquid recovery tube liquid feeding part 7p becomes larger than the flow rate of the cleaning liquid flowing in the connecting tube 9 through the connecting tube liquid feeding part 9p.

[0418] Alternatively, the cleaning liquid recovery pipe liquid feeding portion 7p and the connecting pipe liquid feeding portion 9p may be operated with the flow rate adjustment mechanism 6c closed. In this case, the cleaning liquid is supplied to the filter 10 only from the cleaning liquid bag SB connected to the connecting pipe liquid feeding portion 9p. In this case, the cleaning liquid also passes through the filter component in the direction opposite to the direction in which the filtrate passes through the filter component, so that clogging of the filter component can be eliminated.

[0419] In addition, in Figure 5 When the filter having the hollow fiber membrane 16 is used as the filter 10 as shown, it is desirable that the control unit 106 adjusts the supply amount and supply timing of the cleaning liquid to the filter 10 so that the above-mentioned cleaning of the filter 10 and the concentrator 20 can be properly performed. That is, it is desirable to adjust the supply amount and supply timing of the cleaning liquid to the filter 10 so that the cleaning liquid is passed through the hollow fiber membrane 16 in a state where the hollow space 12h of the trunk 12 is filled with the cleaning liquid until the region to be cleaned in the hollow fiber membrane 16 is filled.

[0420] <Filtrate Recovery>

[0421] On the other hand, when the filter is cleaned by the above method, the filtrate remaining in the internal space 12h of the main body 11 of the filter 10 is mixed with the cleaning liquid and discharged. As a result, the amount of effective components recovered by filtration and concentration is reduced.

[0422] Here, when performing filter cleaning, it is desirable to send the filtrate existing in the internal space 12h of the main body portion 11 of the filter 10 to the concentrator 20 in advance, and then perform filter cleaning.

[0423] <Recovery using cleaning fluid (outside)>

[0424] like Figure 1As shown, the port 11c of the main body 11 of the filter 10 (the port 11c to which the filtrate supply pipe 3 is not connected, hereinafter referred to as the cleaning port 11c) is connected to the cleaning liquid bag SB via a tube. Then, the flow rate adjustment mechanism 3c is used to maintain the state in which the liquid flows in the filtrate supply pipe 3, and the operation of the liquid supply pipe liquid supply part 2p is stopped while the operation of the concentrated liquid pipe liquid supply part 4p is continued, and the function as a clamp is performed. In this state, if the cleaning liquid is supplied from the cleaning liquid bag SB to the filter 10 by the pump provided in the pipe connected to the cleaning port 11c, the filtrate in the internal space 12h of the main body 11 of the filter 10 is supplied to the concentrator 20, and the cleaning liquid is supplied from the cleaning liquid bag SB to the internal space 12h. After a while, if the filtrate in the internal space 12h is completely replaced by the cleaning liquid, the filtrate supply pipe 3 is closed by the flow rate adjustment mechanism 3c, and the operation of the concentrated liquid pipe liquid supply part 4p is stopped. After the filter 10 is in this state, if the filter 10 is cleaned by the above-described method for cleaning the filter 10, re-concentration of the filtrate discharged together with the cleaning liquid can be suppressed.

[0425] In addition, although in the above example, the operation of the liquid supply pipe liquid supply part 2p is stopped to implement the recovery, the recovery can also be implemented while the operation of the liquid supply pipe liquid supply part 2p is maintained. That is, the filtrate in the filter 10 can also be recovered while continuing the filtration and concentration. In this case, it is desirable to adjust the operation of the liquid supply pipe liquid supply part 2p to reduce the amount of the original liquid supplied to the filter 10.

[0426] In addition, whether the filtrate in the internal space 12h is completely replaced by the cleaning liquid can be determined by measuring the delivery volume of the pump provided in the tube connected to the cleaning port 11c to obtain the theoretical value or by measuring the concentration of the concentrated liquid. In addition, it can also be determined by observing the color of the filtrate, measuring the absorbance, or measuring the specific gravity of the filtrate using a hydrometer.

[0427] The pipe connected to the cleaning port 11c of the main body 11 of the filter 10 does not necessarily need to be provided with a pump. In this case, by operating the concentrated liquid pipe liquid feeding unit 4p, the filtrate in the internal space 12h of the main body 11 of the filter 10 can be replaced with the cleaning liquid.

[0428] <Recovery using air and other gases>

[0429] In the above description, the cleaning liquid bag SB is connected to the cleaning port 11c of the main body 11 of the filter 10 via a tube. However, a gas such as air may be supplied to the cleaning port 11c of the main body 11 of the filter 10 via a tube.

[0430] In this case, the flow rate adjustment mechanism 3c is used to maintain the state in which the liquid flows in the filtrate supply pipe 3, and the operation of the liquid supply pipe liquid supply part 2p is stopped while the operation of the concentrated liquid pipe liquid supply part 4p is continued, thereby functioning as a clamp. In this state, if a gas such as air is supplied to the filter 10 from the pipe connected to the cleaning port 11c, the filtrate in the internal space 12h of the main body 11 of the filter 10 is supplied to the concentrator 20. After a while, if the filtrate in the internal space 12h is completely discharged, the filtrate supply pipe 3 is closed by the flow rate adjustment mechanism 3c, and the operation of the concentrated liquid pipe liquid supply part 4p is stopped. After this state, if the filter 10 is cleaned by the cleaning method of the filter 10 as described above, the re-concentration of the filtrate discharged together with the cleaning liquid can be suppressed.

[0431] In addition, although in the above example, the operation of the liquid supply pipe liquid supply part 2p is stopped to implement the recovery, the recovery can also be implemented while the operation of the liquid supply pipe liquid supply part 2p is continued. That is, the filtrate in the filter 10 can also be recovered while continuing the filtration and concentration. In this case, it is desirable to adjust the operation of the liquid supply pipe liquid supply part 2p to reduce the amount of the original liquid supplied to the filter 10.

[0432] In addition, whether the filtrate in the internal space 12 is completely discharged can be determined by installing a liquid detector or a bubble detector in the filtrate supply pipe 3, measuring the pressure of the filtrate supply pipe 3, or measuring the delivery amount of the pump to theoretically determine it.

[0433] Furthermore, when the filtrate in the internal space 12h of the main body 11 of the filter 10 is supplied to the concentrator 20 by a gas such as air, the internal space 12h of the main body 11 of the filter 10 is filled with a gas such as air. Therefore, when a cleaning operation is performed after the filtrate is recovered, it is desirable to perform the cleaning operation after the hollow space 12h of the trunk 12 is filled with a cleaning liquid in advance in the region where the hollow fiber membrane 16 is cleaned (or the entire hollow space 12h of the trunk 12).

[0434] <Recycling to bags>

[0435] In addition, although in the above example, the case where the filtrate is sent to the concentrator 20 and recovered in the state of the concentrated liquid is described, the filtrate can also be recovered in the state of the filtrate. For example, in the filtrate supply pipe 3, a bag for recovering the filtrate is connected to the upstream side of the flow adjustment mechanism 3c (i.e., the filter 10 side). In this state, as long as the cleaning liquid or gas such as air is supplied to the filter 10 from the cleaning port 11c as described above so that the liquid cannot flow in the filtrate supply pipe 3 through the flow adjustment mechanism 3c, the filtrate in the internal space 12h of the main body 11 of the filter 10 can be recovered in the bag. In this case, compared with the case where the filtrate is sent to the concentrator 20 and recovered in the state of the concentrated liquid, the filtrate can be recovered in a short time, so the transition to the cleaning operation can be quickly implemented.

[0436] <Recovery using cleaning fluid (inside)>

[0437] In the above description, the following case is described: the raw liquid is supplied to the through-flow path 16h of the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 of the filter 10, and the filtrate is discharged to the internal space 12h of the trunk 12 of the main body 11 of the filter 10. However, the raw liquid may be supplied from the filtrate discharge port 11c to the internal space 12h of the trunk 12 of the main body 11, and the filtrate obtained by filtration may be discharged to the through-flow path 16h of the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15, and discharged to the outside from the raw liquid supply port 11a.

[0438] In this case, the various tubes and the like are connected as described below.

[0439] First, the filtrate supply pipe 3 is connected to the stock liquid supply port 11a, and the liquid supply pipe 2 is connected to the port 11c (i.e., the above-mentioned cleaning port 11c). In addition, the cleaning liquid supply pipe 6 is connected to the port 11c (i.e., the above-mentioned filtrate discharge port 11c) not connected to the liquid supply pipe 2, and the cleaning liquid bag SB connected to the cleaning port 11c is connected to the cleaning liquid supply port 11b.

[0440] Then, the flow rate adjustment mechanism 3c is used to maintain the state in which the liquid flows in the filtrate supply pipe 3, and the operation of the liquid supply pipe liquid supply part 2p is stopped while the operation of the concentrated liquid pipe liquid supply part 4p is continued, so that it functions as a clamp. In this state, if the cleaning liquid is supplied from the cleaning liquid bag SB to the filter 10 by the pump provided in the pipe connected to the cleaning liquid supply port 11b, the filtrate in the through-flow path 16h of the hollow fiber membrane 16 of the filter 10 is supplied to the concentrator 20, and the cleaning liquid is supplied from the cleaning liquid bag SB to the through-flow path 16h. After a while, if the filtrate in the through-flow path 16h is completely replaced by the cleaning liquid, the filtrate supply pipe 3 is closed by the flow rate adjustment mechanism 3c, and the operation of the concentrated liquid pipe liquid supply part 4p is stopped. After this state is reached, if the filter 10 is cleaned by the cleaning method of the filter 10 as described above, the re-concentration of the filtrate discharged together with the cleaning liquid can be suppressed.

[0441] In addition, although in the above example, the operation of the liquid supply pipe liquid supply part 2p is stopped to implement the recovery, the recovery can also be implemented while the operation of the liquid supply pipe liquid supply part 2p is continued. That is, the filtrate in the filter 10 can also be recovered while continuing the filtration and concentration. In this case, it is desirable to adjust the operation of the liquid supply pipe liquid supply part 2p to reduce the amount of the original liquid supplied to the filter 10.

[0442] In addition, it is possible to determine whether all the filtrate in the internal space 12h has been replaced with the cleaning liquid by measuring the delivery volume of the pump provided in the tube connected to the cleaning port 11c or by measuring the concentration of the concentrated liquid. Alternatively, it is possible to determine whether the filtrate in the internal space 12h has been replaced with the cleaning liquid by observing the color of the filtrate, measuring the absorbance, or measuring the specific gravity of the filtrate using a hydrometer.

[0443] <Recovery using air and other gases>

[0444] In the above description, the cleaning liquid bag SB is connected to the cleaning liquid supply port 11b of the main body 11 of the filter 10 via a tube. However, a gas such as air may be supplied to the cleaning supply port 11b of the main body 11 of the filter 10 via a tube.

[0445] In this case, the flow rate adjustment mechanism 3c is used to maintain the state in which the liquid flows in the filtrate supply pipe 3, and the operation of the liquid supply pipe 2p is stopped while the operation of the concentrated liquid pipe 4p is continued, so that it functions as a clamp. In this state, if a gas such as air is supplied from the pipe to the filter 10, the filtrate in the through-flow path 16h of the hollow fiber membrane 16 of the filter 10 can be supplied to the concentrator 20. After a while, if the filtrate in the through-flow path 16h of the hollow fiber membrane 16 is completely discharged, the filtrate supply pipe 3 is closed by the flow rate adjustment mechanism 3c, and the operation of the concentrated liquid pipe 4p is stopped. After this state, if the filter 10 is cleaned by the cleaning method of the filter 10 as described above, the re-concentration of the filtrate discharged together with the cleaning liquid can be suppressed.

[0446] In addition, although in the above example, the recovery is performed by stopping the operation of the liquid supply pipe liquid supply part 2p, the recovery can also be performed while the operation of the liquid supply pipe liquid supply part 2p is continued. That is, the filtrate in the filter 10 can also be recovered while continuing the filtration and concentration. In this case, it is desirable to adjust the operation of the liquid supply pipe liquid supply part 2p to reduce the amount of the original liquid supplied to the filter 10.

[0447] In addition, whether the filtrate in the through flow path 16h of the hollow fiber membrane 16 is completely discharged can be determined by installing a liquid detector or a bubble detector in the filtrate supply pipe 3, measuring the pressure of the filtrate supply pipe 3, or measuring the delivery amount of the pump to theoretically determine it.

[0448] Furthermore, when the filtrate in the through-flow passage 16h of the hollow fiber membrane 16 of the filter 10 is supplied to the concentrator 20 by a gas such as air, the through-flow passage 16h of the hollow fiber membrane 16 of the filter 10 is filled with a gas such as air. Therefore, when a cleaning operation is performed after the filtrate is recovered, it is desirable to perform the cleaning operation after the through-flow passage 16h is filled with a cleaning liquid until the region to be cleaned in the hollow fiber membrane 16 (or the entire hollow fiber membrane 16) is filled.

[0449] <Recycling to bags>

[0450] In addition, although in the above example, the case where the filtrate is sent to the concentrator 20 and recovered in the state of the concentrated liquid is described, the filtrate can also be recovered in the state of the filtrate. For example, in the filtrate supply pipe 3, a bag for recovering the filtrate is connected in advance on the upstream side of the flow adjustment mechanism 3c (i.e., the filter 10 side). In this state, as long as the cleaning liquid or gas such as air is supplied to the filter 10 from the cleaning liquid supply port 16c as described above so that the liquid cannot flow in the filtrate supply pipe 3 through the flow adjustment mechanism 3c, the filtrate in the through flow path 16h of the hollow fiber membrane 16 of the filter 10 can be recovered in the bag. In this case, compared with the case where the filtrate is sent to the concentrator 20 and recovered in the state of the concentrated liquid, the filtrate can be recovered in a short time, so the transfer to the cleaning operation can be quickly implemented.

[0451] <Other Examples of Methods for Recovering Liquid in Filter 10>

[0452] As described above, when the filtrate in the filter 10 is sent to the concentrator 20 and the filtrate is recovered as a concentrated liquid, it is desirable to adjust the flow rate when sending the liquid to the concentrator 20 based on the differential pressure between the concentrator membranes of the concentrator 20. If such a method is adopted, if the concentrator 20 is clogged, the increase in the differential pressure between the concentrator membranes is suppressed, and the process can be prevented from being stopped, so that the filtrate in the filter 10 can be effectively recovered.

[0453] For example, when adjusting the flow rate when sending the liquid to the concentrator 20 based on the differential pressure between the concentrator membranes of the concentrator 20, the flow rate can be adjusted as follows. First, when the differential pressure between the concentrator membranes of the concentrator 20 is within the range of the set differential pressure, the operation of the concentrated liquid pipe liquid feeding part 4p and the operation of the pump provided in the pipe connected to the cleaning port 11c are controlled to maintain the amount of liquid sent from the filter 10 to the concentrator 20. In this way, it is possible to prevent the occurrence of problems such as the differential pressure between the concentrator membranes greatly deviating from the range of the set differential pressure.

[0454] On the other hand, when the differential pressure between the concentrator membranes of the concentrator 20 is greater than the maximum set differential pressure, the operation of the concentrated liquid pipe liquid feeding section 4p and the operation of the pump provided in the pipe connected to the cleaning port 11c are controlled so as to reduce the amount of liquid fed from the filter 10 to the concentrator 20. This can prevent the differential pressure between the concentrator membranes from rising to the maximum set differential pressure and continuing to rise, causing the process to be unable to continue.

[0455] On the contrary, when the differential pressure between the concentrator membranes of the concentrator 20 is less than the minimum set differential pressure, the operation of the concentrated liquid pipe liquid feeding section 4p and the operation of the pump provided in the pipe connected to the cleaning port 11c are controlled so as to increase the amount of liquid fed from the filter 10 to the concentrator 20. This can prevent the differential pressure between the concentrator membranes from decreasing to the minimum set differential pressure and continuing to decrease, thereby causing the concentrated liquid to be diluted.

[0456] <Another Example of the Method for Recovering the Liquid in the Filter 10>

[0457] As described above, when the filtrate in the filter 10 is sent to the concentrator 20 to recover the filtrate as a concentrated liquid, the flow rate from the concentrator 20 to the concentrated liquid bag CB and / or the flow rate from the concentrator 20 to the waste liquid bag DB, that is, the concentration ratio, may be adjusted based on the differential pressure between the concentrator membranes of the concentrator 20. In the case of this method, while suppressing the increase in the differential pressure between the concentrator membranes, the speed of recovering the concentrated liquid can be kept constant without changing the flow rate sent from the filter 10 to the concentrator 20, so that the filtrate in the filter 10 can be effectively recovered.

[0458] For example, when adjusting the flow rate from the concentrator 20 to the concentrated liquid bag CB and / or the flow rate from the concentrator 20 to the waste liquid bag DB based on the concentrator inter-membrane pressure difference of the concentrator 20, the flow rate can be adjusted as follows.

[0459] First, when the differential pressure between the concentrator membranes of the concentrator 20 is within the range of the set differential pressure, the operation of the concentrated liquid pipe liquid feeding section 4p (the operation of the waste liquid pipe liquid feeding section 5p when the waste liquid pipe liquid feeding section 5p is provided) or the operation of the pump provided in the pipe connected to the cleaning port 11c is controlled to maintain the flow rate from the concentrator 20 to the concentrated liquid bag CB and / or the flow rate from the concentrator 20 to the waste liquid bag DB. This can prevent the occurrence of problems such as the differential pressure between the concentrator membranes greatly deviating from the range of the set differential pressure.

[0460] On the other hand, when the differential pressure between the concentrator membranes of the concentrator 20 is greater than the maximum set differential pressure, the operation of the concentrated liquid pipe liquid feeding section 4p (the operation of the waste liquid pipe liquid feeding section 5p when the waste liquid pipe liquid feeding section 5p is provided) or the operation of the pump provided in the pipe connected to the cleaning port 11c is controlled so that the flow rate from the concentrator 20 to the concentrated liquid bag CB is increased and / or the flow rate from the concentrator 20 to the waste liquid bag DB is reduced. This can prevent the differential pressure between the concentrator membranes from rising to the maximum set differential pressure and continuing to rise, which may cause the process to be unable to continue.

[0461] On the contrary, when the differential pressure between the concentrator membranes of the concentrator 20 is less than the minimum set differential pressure, the operation of the concentrated liquid pipe liquid feeding section 4p (the operation of the waste liquid pipe liquid feeding section 5p when the waste liquid pipe liquid feeding section 5p is provided) or the operation of the pump provided in the pipe connected to the cleaning port 11c is controlled so that the flow rate from the concentrator 20 to the concentrated liquid bag CB is reduced and / or the flow rate from the concentrator 20 to the waste liquid bag DB is increased. Thus, it is possible to prevent the situation where the differential pressure between the concentrator membranes continues to decrease after it drops to the minimum set differential pressure, resulting in the dilution of the concentrated liquid.

[0462] In addition, the set differential pressure of the differential pressure between the concentrator membranes when recovering the filtrate of the filter 10 can be set to the same as the allowable differential pressure in the filtering and concentrating operation, or the set differential pressure can be set to a value (range) different from the allowable differential pressure. For example, in the case where the allowable differential pressure has a certain range, the range of the set differential pressure can be set larger than the range of the allowable differential pressure. In this case, it is expected that the concentrated liquid can be recovered as much as possible to the end even in a diluted state. In addition, in the case where the range of the set differential pressure is set to be smaller than the range of the allowable differential pressure, it is expected that the concentrated liquid will not be diluted even if time is consumed, and can be recovered as much as possible to the end. Furthermore, there may be a deviation between the range of the allowable differential pressure and the range of the set differential pressure.

[0463] <Re-enrichment Operation>

[0464] When the concentrated liquid obtained by the filtration concentration operation is further concentrated, a re-concentration operation is performed.

[0465] like Figure 3 As shown, in the re-concentration operation of the raw liquid processing apparatus 1 of the first embodiment, the other end of the connecting tube 9 is removed from the cleaning liquid bag SB, and the other end of the connecting tube 9 is connected to the concentrated liquid bag CB.

[0466] In addition, the flow rate adjustment mechanism 3c is used to maintain the state in which the liquid can flow in the filtrate supply pipe 3, and on the other hand, the liquid supply pipe liquid delivery part 2p and the cleaning liquid recovery pipe liquid delivery part 7p are not operated and function as a clamp. In addition, the flow rate adjustment mechanism 6c is used to seal the cleaning liquid supply pipe 6 so that the liquid cannot flow. As a result, the filter 10 is in a state in which the liquid cannot flow.

[0467] In the above state, the connecting tube liquid feeding section 9p is operated so that the concentrated liquid flows from the concentrated liquid bag CB to the concentrator 20 through the connecting tube 9, and the concentrated liquid tube liquid feeding section 4p is operated so that the concentrated liquid flows from the concentrator 20 to the concentrated liquid bag CB through the concentrated liquid tube 4.

[0468] Thus, the concentrated liquid is supplied to the concentrator 20 from the concentrated liquid bag CB connected to the connecting tube 9 through the connecting tube 9, and the re-concentrated liquid further concentrated by the concentrator 20 is recovered to the concentrated liquid bag CB through the concentrated liquid tube 4. On the other hand, the water separated from the concentrated liquid is recovered to the waste liquid bag DB through the waste liquid tube 5. That is, a concentrated liquid (re-concentrated liquid) with a higher concentration ratio can be obtained.

[0469] <Description of re-concentration operation using differential pressure between concentrator membranes>

[0470] In the reconcentration operation, the flow rate from the concentrator 20 to the concentrated liquid bag CB and / or the flow rate from the concentrator 20 to the waste liquid bag DB, i.e., the reconcentration ratio, may be adjusted based on the differential pressure between the concentrator membranes of the concentrator 20. In the case of this method, the effect of being able to shorten the time to generate a high-concentration concentrated liquid while suppressing the increase in the differential pressure between the concentrator membranes can be obtained.

[0471] In this case, when the re-concentration operation using the differential pressure between the concentrator membranes is performed in advance, it is desirable to set the allowable differential pressure. That is, the differential pressure (allowable differential pressure) that the concentrator 20 can allow is set according to the concentrator 20. The allowable differential pressure can have a predetermined range or be set to a specific value. In addition, the following description is based on the case where the allowable differential pressure has a predetermined range as a representative.

[0472] In addition, in the case of performing a reconcentration operation utilizing the filter membrane, it is desirable to pre-set the allowable flow rate. That is, it is desirable to set the flow rate (allowable flow rate) that the stock solution in the connecting pipe 9 can allow. The allowable flow rate may have a specified amplitude, or may be set to a specific value. The allowable flow rate does not necessarily have to be set. However, if the flow rate of the stock solution in the connecting pipe 9 is too small, the time consumed for reconcentration becomes too long. Therefore, from the perspective of the invention to prevent the processing time of the concentrated solution from becoming longer, it is desirable to pre-set the allowable flow rate. In addition, the allowable flow rate in the reconcentration operation may be the same as the allowable flow rate in the filtration concentration, or it may be different from the allowable flow rate in the filtration concentration.

[0473] Furthermore, in the case of a re-concentration operation utilizing the differential pressure between the concentrator membranes, it is desirable to pre-set an allowable concentration ratio. That is, it is desirable to set a ratio (allowable concentration ratio) of the flow rate of the concentrated liquid flowing in the concentrated liquid pipe 4 to the flow rate of the concentrated liquid in the connecting pipe 9. The allowable concentration ratio may have a prescribed amplitude or may be set to a specific value. The allowable concentration ratio does not necessarily have to be set. However, if the concentration ratio, which is the ratio of the flow rate of the concentrated liquid flowing in the concentrated liquid pipe 4 to the flow rate of the concentrated liquid in the connecting pipe 9, is too low (i.e., the flow rate of the concentrated liquid becomes too large), the concentration of the concentrated liquid becomes thinner (the amount of water in the concentrated liquid increases), and therefore, the re-concentration process requires time. Therefore, in order to prevent the concentration ratio from being excessively reduced, it is desirable to pre-set the allowable concentration ratio. In addition, the allowable concentration ratio in the re-concentration operation may be the same as or different from the allowable concentration ratio in the filtration concentration.

[0474] At the start of reconcentration, the connecting pipe liquid delivery section 9p is operated to increase the amount of concentrated liquid delivered to the concentrator 20. At this time, the concentrated liquid pipe liquid delivery section 4p is operated in a manner that matches the flow rate of the concentrated liquid in the connecting pipe 9 so that the concentrated liquid reaches a predetermined concentration ratio. For example, in the case of generating a concentrated liquid with a concentration ratio of 10 times, the operation of the concentrated liquid pipe liquid delivery section 4p can be adjusted so that the flow rate of the concentrated liquid flowing in the concentrated liquid pipe 4 reaches 1 / 10 of the flow rate of the concentrated liquid flowing in the connecting pipe 9. In addition, the operation of the concentrated liquid pipe liquid delivery section 4p can sometimes be adjusted so that the differential pressure between the concentrator membranes becomes a set value within the allowable differential pressure (or is maintained within the allowable differential pressure) instead of the concentration ratio of the concentrated liquid, or the differential pressure between the concentrator membranes becomes a set value within the allowable differential pressure (or is maintained within the allowable differential pressure) while maintaining the concentrated liquid at a predetermined concentration ratio. In addition, during the period of increasing the amount of concentrated liquid delivered to the concentrator 20, the operation of the concentrated liquid pipe liquid delivery section 4p is controlled to be in any of the above-mentioned states.

[0475] As re-concentration progresses, the concentrator 20 gradually becomes clogged. As a result, the differential pressure between the concentrator membranes increases. However, the connecting pipe liquid feeding section 9p is operated to increase the amount of concentrated liquid fed to the concentrator 20 until the differential pressure between the concentrator membranes reaches the allowable differential pressure.

[0476] <First Method>

[0477] The amount of concentrated liquid delivered to the concentrator 20 is continuously increased until the differential pressure between the concentrator membranes reaches within the allowable differential pressure of the concentrator 20. Furthermore, when the differential pressure between the concentrator membranes reaches within the allowable differential pressure of the concentrator 20, the connecting pipe liquid delivery portion 9p is controlled so that the flow rate of the concentrated liquid in the connecting pipe 9 is maintained at a flow rate at which the differential pressure between the concentrator membranes becomes within the allowable differential pressure of the concentrator 20. On the other hand, the concentrated liquid pipe liquid delivery portion 4p is operated as described below based on the differential pressure between the concentrator membranes to adjust the flow rate of the concentrated liquid flowing in the concentrated liquid pipe 4.

[0478] <Step 1>

[0479] First, when the differential pressure between the concentrator membranes is less than the minimum allowable differential pressure of the concentrator 20, the concentrated liquid pipe feeder 4p is operated to reduce the amount of concentrated liquid delivered to the concentrated liquid bag CB. That is, the operation of the concentrated liquid pipe feeder 4p is controlled to increase the concentration of the concentrated liquid.

[0480] <Step 2>

[0481] Then, the amount of concentrate delivered to the concentrate bag CB is reduced until the differential pressure between the concentrator membranes reaches within the allowable differential pressure of the concentrator 20. If the differential pressure between the concentrator membranes reaches within the allowable differential pressure of the concentrator 20, the concentrate pipe delivery section 4p is controlled so that the flow rate of the concentrate in the concentrate pipe 4 is maintained at a flow rate in a state where the differential pressure between the concentrator membranes reaches within the allowable differential pressure of the concentrator 20.

[0482] <Step 3>

[0483] After a while, if the differential pressure between the concentrator membranes becomes greater than the maximum allowable differential pressure of the concentrator 20 due to clogging of the concentrator 20 or the like, the concentrated liquid pipe delivery portion 4p is controlled so that the amount of concentrated liquid delivered to the concentrated liquid bag CB is increased. In addition, although the concentration ratio is reduced as the amount of concentrated liquid delivered increases, the operation of the concentrated liquid pipe delivery portion 4p is controlled so that the concentration ratio is reduced (the concentration of the concentrated liquid is reduced) while satisfying the allowable concentration ratio.

[0484] When the delivery rate of the concentrated liquid is increased to maintain the differential pressure between the concentrator membranes within the allowable differential pressure range and the concentration ratio becomes smaller than the allowable concentration ratio, the following method (second method) can be used to cope with the situation.

[0485] Since the differential pressure between the concentrator membranes decreases as the amount of concentrate delivered to the concentrate bag CB increases, when the differential pressure between the concentrator membranes becomes lower than the minimum allowable differential pressure of the concentrator 20, the concentrate pipe delivery part 4p is operated again to reduce the amount of concentrate delivered to the concentrate bag CB.

[0486] That is, the above steps 1 to 3 are repeatedly performed while the differential pressure between the concentrator membranes is within the allowable differential pressure of the concentrator 20. According to this method, it is possible to ensure that the maximum concentration ratio corresponding to the membrane area and the clogging state of the filter membrane of the concentrator 20 or the state of the concentrated liquid (the concentration of the substance causing the clogging of the concentrator, the concentration of the recovered useful substance, the viscosity of the liquid, etc.), which cannot be achieved when the amount of liquid sent to the concentrated liquid bag CB is constant, can be achieved. That is, by improving the concentration efficiency, the time to generate a high-concentration concentrated liquid can be shortened, and the time required for the re-concentration operation can be shortened.

[0487] <Second Method>

[0488] In the first method, the flow rate of the concentrate in the concentrate pipe 4 is adjusted based on the concentrator inter-membrane pressure difference. The flow rate of the concentrate in the connecting pipe 9 can also be adjusted based on the concentrator inter-membrane pressure difference as described below.

[0489] <Step 1>

[0490] First, when the differential pressure between the concentrator membranes is smaller than the minimum allowable differential pressure of the concentrator 20 , the connecting pipe liquid feeding section 9 p is operated to increase the amount of concentrated liquid fed to the concentrator 20 .

[0491] <Step 2>

[0492] Then, the amount of concentrated liquid delivered to the concentrator 20 is increased until the differential pressure between the concentrator membranes reaches within the allowable differential pressure of the concentrator 20. Furthermore, if the differential pressure between the concentrator membranes reaches within the allowable differential pressure of the concentrator 20, the operation of the connecting pipe liquid delivery section 9p is controlled so that the flow rate of the concentrated liquid in the connecting pipe 9 is maintained at a flow rate in a state where the differential pressure between the concentrator membranes reaches within the allowable differential pressure of the concentrator 20. In addition, in this case, it is desirable to maintain the flow rate of the concentrated liquid in the connecting pipe 9 within the allowable flow rate (above the minimum allowable flow rate and below the maximum allowable flow rate).

[0493] <Step 3>

[0494] If the differential pressure between the concentrator membranes becomes greater than the maximum allowable differential pressure of the concentrator 20 due to clogging of the concentrator 20 or the like soon after, the operation of the connecting pipe liquid feeding section 9p is controlled so that the flow rate of the concentrated liquid in the connecting pipe 9 is reduced. That is, the operation of the connecting pipe liquid feeding section 9p is controlled so that the flow rate delivered to the concentrator 20 is reduced. In addition, in this case, it is also desirable to maintain the flow rate of the concentrated liquid in the connecting pipe 9 within the allowable flow rate.

[0495] If the flow rate of the concentrate in the connecting pipe 9 decreases, the differential pressure between the concentrator membranes decreases. Therefore, if the differential pressure between the concentrator membranes becomes lower than the minimum allowable differential pressure of the concentrator 20, the connecting pipe liquid feeding part 9p is operated again to increase the flow rate of the concentrate in the connecting pipe 9.

[0496] That is, the above steps 1 to 3 are repeatedly performed while the differential pressure between the concentrator membranes is within the allowable differential pressure of the concentrator 20. According to this method, it is possible to ensure the maximum recirculation flow rate and the maximum concentration ratio corresponding to the membrane area and the clogging state of the filter membranes of the filter 10 and the concentrator 20, or the state of the raw liquid (the concentration of the substance causing the clogging of the filter and the concentrator, or the concentration of the recovered useful substance, the viscosity of the liquid, etc.), which cannot be achieved when the liquid feeding amount to the concentrator 20 is constant. That is, by improving the recirculation efficiency and the concentration efficiency, the time to generate a high-concentration concentrated liquid can be shortened, and the time required for the re-concentration operation can be shortened.

[0497] In addition, the allowable differential pressure of the differential pressure between the concentrator membranes during reconcentration can be set to the same as the allowable differential pressure in the filtration and concentration operation, or it can be set to a value (range) different from the allowable differential pressure in the filtration and concentration operation. For example, in the case where the allowable differential pressure in the filtration and concentration operation has a certain range, the range of the allowable differential pressure in the reconcentration can also be made wider than the range. In this case, although the original liquid with the property of easy clogging of the filter 10 is processed slowly in a manner without applying pressure to the filter 10 in the filtration operation, it is relatively expected that a high-concentration concentrated liquid can be generated, and the reconcentration time can be shortened. In addition, in the case where the range of the allowable differential pressure in the reconcentration is set to be narrower than the range of the allowable differential pressure in the filtration and concentration operation, when the original liquid with the property of easy clogging of the concentrator 20 is processed, the concentrator 20 is processed in a short time without applying pressure in the filtration and concentration operation, and it is relatively expected that a high-concentration concentrated liquid can be generated by the reconcentration operation. Furthermore, there can also be a deviation between the range of the allowable differential pressure in the filtration and concentration operation and the range of the allowable differential pressure in the reconcentration.

[0498] In addition, the allowable concentration ratio during reconcentration can be set to the same as the allowable concentration ratio in the filtration and concentration operation, or it can be set to a value (range) different from the allowable concentration ratio in the filtration and concentration operation. For example, in the case where the allowable concentration ratio in the filtration and concentration operation has a certain range, the range of the allowable concentration ratio in the reconcentration can also be set larger than the range. In this case, it takes time to concentrate in the filtration and concentration operation, and it is relatively expected that the time of the reconcentration operation can be shortened. In addition, in the case where the range of the allowable concentration ratio in the reconcentration is set to be narrower than the range of the allowable concentration ratio in the filtration and concentration operation, it takes time to concentrate in the reconcentration operation, and it is relatively expected that the filtration and concentration operation can be quickly ended. Furthermore, there can also be a deviation between the range of the allowable concentration ratio in the filtration and concentration operation and the range of the allowable concentration ratio in the reconcentration.

[0499] <Example of a method for recovering liquid in the filter 10>

[0500] Before the above-mentioned re-concentration operation is performed, the filtrate in the filter 10 is sent to the concentrator 20, and the filtrate is recovered as a concentrated liquid. In this case, it is desirable to adjust the flow rate when the liquid is sent to the concentrator 20 based on the differential pressure between the concentrator membranes of the concentrator 20. If such a method is adopted, even if the concentrator 20 is clogged, the increase in the differential pressure between the concentrator membranes is suppressed, and the process can be prevented from stopping, so that the filtrate in the filter 10 can be effectively recovered.

[0501] For example, when adjusting the flow rate when sending the liquid to the concentrator 20 based on the differential pressure between the concentrator membranes of the concentrator 20, the flow rate can be adjusted as follows. First, when the differential pressure between the concentrator membranes of the concentrator 20 is within the range of the set differential pressure, the operation of the concentrated liquid pipe liquid feeding part 4p and the operation of the pump provided in the pipe connected to the cleaning port 11c are controlled to maintain the amount of liquid sent from the filter 10 to the concentrator 20. In this way, it is possible to prevent the occurrence of problems such as the differential pressure between the concentrator membranes greatly deviating from the range of the set differential pressure.

[0502] On the other hand, when the differential pressure between the concentrator membranes of the concentrator 20 is greater than the maximum set differential pressure, the operation of the concentrated liquid pipe liquid feeding section 4p and the operation of the pump provided in the pipe connected to the cleaning port 11c are controlled so that the amount of liquid fed from the filter 10 to the concentrator 20 is reduced. This can prevent the situation where the differential pressure between the concentrator membranes rises to the maximum set differential pressure and continues to rise, resulting in the inability to continue the treatment. Conversely, when the differential pressure between the concentrator membranes of the concentrator 20 is less than the minimum set differential pressure, the operation of the concentrated liquid pipe liquid feeding section 4p and the operation of the pump provided in the pipe connected to the cleaning port 11c are controlled so that the amount of liquid fed from the filter 10 to the concentrator 20 is increased. This can prevent the situation where the differential pressure between the concentrator membranes drops to the minimum set differential pressure and continues to decrease, resulting in the dilution of the concentrated liquid.

[0503] <Another Example of the Method for Recovering the Liquid in the Filter 10>

[0504] Furthermore, when the filtrate in the filter 10 is sent to the concentrator 20 and the filtrate is recovered as a concentrated liquid, the flow rate from the concentrator 20 to the concentrated liquid bag CB and / or the flow rate from the concentrator 20 to the waste liquid bag DB, that is, the concentration ratio, may be adjusted based on the differential pressure between the concentrator membranes of the concentrator 20. In this method, while suppressing the increase in the differential pressure between the concentrator membranes, the flow rate of the liquid sent from the filter 10 to the concentrator 20 can be kept constant, and the recovery rate can be kept constant, so that the filtrate in the filter 10 can be effectively recovered.

[0505] For example, when adjusting the flow rate from the concentrator 20 to the concentrated liquid bag CB and / or the flow rate from the concentrator 20 to the waste liquid bag DB based on the concentrator inter-membrane pressure difference of the concentrator 20, the flow rate can be adjusted as follows.

[0506] First, when the differential pressure between the concentrator membranes of the concentrator 20 is within the range of the set differential pressure, the operation of the concentrated liquid pipe liquid feeding section 4p (the operation of the waste liquid pipe liquid feeding section 5p when the waste liquid pipe liquid feeding section 5p is provided) or the operation of the pump provided in the pipe connected to the cleaning port 11c is controlled to maintain the flow rate from the concentrator 20 to the concentrated liquid bag CB and / or the flow rate from the concentrator 20 to the waste liquid bag DB. This can prevent the occurrence of problems such as the differential pressure between the concentrator membranes greatly deviating from the range of the set differential pressure.

[0507] On the other hand, when the differential pressure between the concentrator membranes of the concentrator 20 is greater than the maximum set differential pressure, the operation of the concentrated liquid pipe liquid feeding section 4p (the operation of the waste liquid pipe liquid feeding section 5p when the waste liquid pipe liquid feeding section 5p is provided) or the operation of the pump provided in the pipe connected to the cleaning port 11c is controlled so that the flow rate from the concentrator 20 to the concentrated liquid bag CB is increased and / or the flow rate from the concentrator 20 to the waste liquid bag DB is reduced. This can prevent the differential pressure between the concentrator membranes from rising to the maximum set differential pressure and continuing to rise, which may cause the process to be unable to continue.

[0508] On the contrary, when the differential pressure between the concentrator membranes of the concentrator 20 is less than the minimum set differential pressure, the operation of the concentrated liquid pipe liquid feeding section 4p (the operation of the waste liquid pipe liquid feeding section 5p when the waste liquid pipe liquid feeding section 5p is provided) or the operation of the pump provided in the pipe connected to the cleaning port 11c is controlled so that the flow rate from the concentrator 20 to the concentrated liquid bag CB is reduced and / or the flow rate from the concentrator 20 to the waste liquid bag DB is increased. Thus, it is possible to prevent the situation where the differential pressure between the concentrator membranes continues to decrease after it drops to the minimum set differential pressure, resulting in the dilution of the concentrated liquid.

[0509] In addition, the set differential pressure of the differential pressure between the concentrator membranes when recovering the filtrate of the filter 10 can be set to the same as the allowable differential pressure in the filtering and concentrating operation, or the set differential pressure can be set to a value (range) different from the allowable differential pressure. For example, in the case where the allowable differential pressure has a certain range, the range of the set differential pressure can be set larger than the range of the allowable differential pressure. In this case, it is expected that the concentrated liquid can be recovered as much as possible to the end even in a diluted state. In addition, in the case where the range of the set differential pressure is set to be smaller than the range of the allowable differential pressure, it is expected that the concentrated liquid will not be diluted even if time is consumed, and can be recovered as much as possible to the end. Furthermore, there may be a deviation between the range of the allowable differential pressure and the range of the set differential pressure.

[0510] <Recovery Operation of Concentrator 20>

[0511] When the concentrated liquid in the concentrator 20 is also recovered after the raw liquid and filtrate in the filter 10 are recovered, only the cleaning liquid or the fluid called gas (hereinafter simply referred to as fluid) can be made to flow in the concentrator 20 to recover the concentrated liquid. However, as in the above case, the differential pressure between the concentrator membranes can be measured and the flow rate of the fluid supplied to the concentrated liquid 20 can be adjusted. In this way, it is possible to prevent the occurrence of problems such as the differential pressure between the concentrator membranes becoming large and the inability to continue processing. Then, if the differential pressure between the concentrator membranes of the concentrator 20 is greater than the maximum set differential pressure, as long as the liquid (including the flowing gas) is stopped from being sent from the filter 10 to the concentrator 20, it is possible to prevent the differential pressure between the concentrator membranes from continuing to rise.

[0512] In addition, the set differential pressure (second set differential pressure) of the differential pressure between the concentrator membranes when recovering the concentrated liquid of the concentrator 20 can be set to the same as the allowable differential pressure in the filtration and concentration operation or the set differential pressure (first set differential pressure) when recovering the filtrate of the filter 10, or it can be set to a value (range) different from these. For example, in the case where the allowable differential pressure and the first set differential pressure have a certain degree of range, the range of the second set differential pressure can be set larger than the range of the allowable differential pressure and the first set differential pressure. In this case, it is expected that the concentrated liquid can be recovered as much as possible to the end even in a diluted state. In addition, in the case where the range of the set differential pressure is set to be smaller than the range of the allowable differential pressure, it is expected that the concentrated liquid will not be diluted even if it takes time, and can be recovered as much as possible to the end. Furthermore, there may be deviations in the range of the second set differential pressure relative to the range of the allowable differential pressure and the range of the first set differential pressure.

[0513] <Recovery of Liquid in Filtrate Supply Pipe 3>

[0514] In addition, after the recovery of the concentrated liquid in the above-mentioned concentrator 20 is implemented, when the differential pressure between the membranes of the concentrator reaches the set differential pressure or a predetermined amount of liquid is recovered, etc., after stopping the liquid (including the flowing gas) from the filter 10 to the concentrator 20, a gas such as air can be supplied to the filtrate supply pipe 3. In this way, it is possible to prevent the concentrated liquid in the concentrator 20 or the concentrated liquid flow path 4, and the liquid in the flow path downstream of the filtrate supply pipe 3 from being missed in the recovery. In addition, if the differential pressure between the membranes of the concentrator does not reach the set differential pressure, it is not necessary to stop the liquid from the filter 10 to the concentrator 20.

[0515] <Stock Liquid Treatment Device 1B of Second Embodiment>

[0516] In the raw liquid treatment apparatus 1 of the first embodiment described above, the raw liquid is supplied to the filter 10 by injecting the raw liquid during filtration and concentration. However, the raw liquid may be supplied to the filter 10 by sucking the raw liquid out of the filter 10 .

[0517] That is, Figure 7 As shown, in the raw liquid treatment device 1B of the second embodiment, the raw liquid is supplied to the filter 10 in a manner of sucking the raw liquid out from the filter 10. That is, the raw liquid treatment device 1B of the second embodiment is the raw liquid treatment device 1 of the first embodiment, wherein the filtrate supply pipe 3 is provided with a filtrate supply pipe liquid delivery portion 3p instead of the flow rate adjustment mechanism 3c, and the liquid supply pipe 2 is provided with a flow rate adjustment mechanism 2c instead of the liquid supply pipe liquid delivery portion 2p.

[0518] In the raw liquid processing device 1B, the filtrate supply pipe liquid delivery part 3p is operated during filtration and concentration to allow the liquid (filtrate) to flow from the filter 10 to the concentrator 20. When the filtrate supply pipe liquid delivery part 3p is operated, the upstream side of the filtrate supply pipe liquid delivery part 3p in the filtrate supply pipe 3, that is, the filter 10 side, becomes negative pressure, and the inside of the filter 10 (for example, the internal space 12h of the trunk 12 of the main body 11) also becomes negative pressure. Therefore, if the liquid supply pipe 2 is made to be in a state where liquid can be transported by the flow adjustment mechanism 2c, the raw liquid in the raw liquid bag UB can be sucked into the filter 10 through the liquid supply pipe 2, and the sucked raw liquid can be sucked into the filtrate supply pipe 3.

[0519] In the raw liquid treatment device 1B, if the bags connected to the respective tubes are appropriately changed and the flow rate adjustment mechanism and the operation of the liquid delivery section provided in the respective tubes are adjusted, the preparatory cleaning operation, the filtration concentration operation and the re-concentration operation can be performed. In addition, in the raw liquid treatment device 1B, a waste liquid tube liquid delivery section 5p may be provided in the waste liquid tube 5 instead of the concentrated liquid tube liquid delivery section 4p (see Fig. 9 Even in this case, as long as the waste liquid pipe feeding section 5p reduces the amount of waste liquid delivered under the condition that the concentrate pipe feeding section 4p increases the amount of concentrate delivered, and as long as the waste liquid pipe feeding section 5p increases the amount of waste liquid delivered under the condition that the concentrate pipe feeding section 4p reduces the amount of concentrate delivered, the same function as the case where the concentrate pipe feeding section 4p is provided in the concentrate pipe 4 is achieved. The case where the concentrate pipe feeding section 4p is provided in the concentrate pipe 4 is described below.

[0520] <Preparation for cleaning>

[0521] like Figure 6As shown, the cleaning liquid bag SB is connected to the other end of the concentrate tube 4 instead of the concentrate bag CB, and the cleaning liquid recovery bag FB is connected to the other end of the waste liquid tube 5 instead of the waste liquid bag DB. In addition, the other end of the waste liquid tube 5 can remain connected to the waste liquid bag DB, or it can be simply arranged in a bucket or the like.

[0522] In addition, the cleaning liquid recovery bag FB is also connected to the other end of the liquid supply tube 2 instead of the original liquid bag UB. In addition, the waste liquid bag DB can be connected to the other end of the liquid supply tube 2, and the other end of the liquid supply tube 2 can also be simply configured in a bucket or the like.

[0523] And the cleaning liquid recovery bag FB is also connected to the other end of the connection pipe 9. In addition, the waste liquid bag DB may be connected to the other end of the connection pipe 9, and the other end of the connection pipe 9 may be simply arranged in a bucket or the like.

[0524] Furthermore, the cleaning liquid recovery bag FB is connected to the other end of the cleaning liquid supply pipe 6 instead of the cleaning liquid bag SB, and the cleaning liquid bag SB is connected to the other end of the cleaning liquid recovery pipe 7 instead of the cleaning liquid recovery bag FB. In addition, the waste liquid bag DB may be connected to the other end of the cleaning liquid supply pipe 6 and the other end of the cleaning liquid recovery pipe 7, or the other end of the cleaning liquid supply pipe 6 and the other end of the cleaning liquid recovery pipe 7 may be simply arranged in a bucket or the like.

[0525] Next, the flow rate regulating mechanism 2 c and the flow rate regulating mechanism 2 c are opened to allow the cleaning liquid to flow through the liquid supply pipe 2 and the connecting pipe 9 .

[0526] In the above state, the concentrate pipe liquid delivery part 4p is operated so that the cleaning liquid flows from the cleaning liquid bag SB connected to the concentrate pipe 4 to the concentrator 20, and the filtrate supply pipe liquid delivery part 3p is operated so that the cleaning liquid flows from the concentrator 20 (i.e., the filtrate supply pipe 3) to the cleaning liquid recovery bag FB connected to the connection pipe 9. Thus, the cleaning liquid is supplied from the cleaning liquid bag SB connected to the concentrate pipe 4 to the concentrator 20 through the concentrate pipe 4. After passing through the concentrator 20, the supplied cleaning liquid is recovered to the cleaning liquid recovery bag FB connected to the connection pipe 9 through the filtrate supply pipe 3 and the connection pipe 9. In addition, a part of the cleaning liquid is recovered to the cleaning liquid recovery bag FB connected to the other end of the waste liquid pipe 5 through the waste liquid pipe 5.

[0527] In addition, the cleaning liquid recovery pipe liquid delivery part 7p is operated in such a manner that the cleaning liquid flows from the cleaning liquid bag SB connected to the cleaning liquid recovery pipe 7 to the filter 10. Thus, a part of the cleaning liquid is supplied to the filter 10 from the cleaning liquid bag SB connected to the cleaning liquid recovery pipe 7 through the cleaning liquid recovery pipe 7. After passing through the filter 10, the cleaning liquid supplied to the filter 10 is recovered to the cleaning liquid recovery bag FB connected to the connection pipe 9 through the filtrate supply pipe 3 and the connection pipe 9. In addition, by operating the cleaning liquid supply pipe liquid delivery part 6p, a part of the cleaning liquid supplied to the filter 10 can also flow to the cleaning liquid supply pipe 6. Furthermore, a part of the cleaning liquid is recovered from the cleaning liquid recovery pipe 7 through the liquid supply pipe 2 to the cleaning liquid recovery bag FB connected to the liquid supply pipe 2.

[0528] Thus, the cleaning liquid can flow through the filter 10, the concentrator 20, and all the tubes, and thus the entire raw liquid treatment apparatus 1B of the second embodiment can be cleaned.

[0529] <Filtration and concentration work>

[0530] When the cleaning operation is completed, the filtration and concentration operation is performed.

[0531] like Figure 7 As shown, in the filtration and concentration operation of the raw liquid treatment device 1B of the second embodiment, from the state of preparing for the cleaning operation (refer to Figure 6 ) Connect the concentrate bag CB to the other end of the concentrate tube 4 instead of the cleaning liquid bag SB, and connect the waste liquid bag DB to the other end of the waste liquid tube 5 instead of the cleaning liquid recovery bag FB.

[0532] On the other hand, the original liquid bag UB is connected to the other end of the liquid supply tube 2 instead of the cleaning liquid recovery bag FB.

[0533] In addition, the flow rate adjustment mechanism 2c is opened to maintain the state in which the liquid can flow in the liquid supply tube 2, and on the other hand, the flow rate adjustment mechanism 9c is closed so that the liquid cannot flow in the connecting tube 9. In addition, the cleaning liquid recovery tube liquid delivery part 7p and the cleaning liquid supply tube liquid delivery part 6p are not operated and function as a clamp.

[0534] In the above state, the filtrate supply pipe liquid delivery portion 3p is operated so that the filtrate flows from the filter 10 to the concentrator 20, and the concentrated liquid pipe liquid delivery portion 4p is operated so that the concentrated liquid flows from the concentrator 20 to the concentrated liquid bag CB.

[0535] Thus, the stock solution is supplied from the stock solution bag UB to the filter 10 through the liquid supply pipe 2. The supplied stock solution is filtered by the filter 10, and the generated filtrate is supplied to the concentrator 20 through the filtrate supply pipe 3. Then, the filtrate supplied to the concentrator 20 is concentrated by the concentrator 20, and the generated concentrated liquid is recovered to the concentrated liquid bag CB through the concentrated liquid pipe 4. On the other hand, the water separated from the concentrated liquid is recovered to the waste liquid bag DB through the waste liquid pipe 5.

[0536] <About Filtration and Concentration Operation>

[0537] Here, in the filtration and concentration operation, the operation of the filtrate supply pipe liquid delivery part 3p and the concentrate pipe liquid delivery part 4p is controlled so that the concentration ratio is within a predetermined range. However, as described below, the operation of the filtrate supply pipe liquid delivery part 3p and the concentrate pipe liquid delivery part 4p may be controlled by using the filter membrane differential pressure and the concentrator membrane differential pressure, that is, the flow rate of the liquid flowing in the filtrate supply pipe 3 and the concentrate pipe 4 is controlled. In this way, the capacity of the filter 10 and the concentrator 20 can be effectively utilized to perform filtration and concentration, so the time until the concentrated liquid is generated can be shortened, and the efficiency of the concentration operation can be improved.

[0538] Hereinafter, the operation of performing filtration and concentration by controlling the operation of the filtrate supply pipe liquid feeding section 3p and the concentrated liquid pipe liquid feeding section 4p using the filter inter-membrane pressure difference and the concentrator inter-membrane pressure difference will be described.

[0539] In addition, the differential pressure between the filter membranes and the differential pressure between the concentrator membranes can be calculated by measuring the internal pressure of the pipes connected to the filter 10 and the concentrator 20. For example, as long as a pressure gauge is set in advance on the liquid supply pipe 2 and the filtrate supply pipe 3, and the signal is supplied to the control unit 106, the control unit 106 can calculate the differential pressure between the filter membranes. In addition, even if a pressure gauge is set at the port 11c (or the pipe connected to the port 11c) to which the filtrate supply pipe 3 is not connected, the control unit 106 can calculate the differential pressure between the filter membranes. In addition, as long as a pressure gauge is set in advance on the filtrate supply pipe 3 and the waste liquid pipe 5, and the signal is supplied to the control unit 106, the control unit 106 can calculate the differential pressure between the concentrator membranes. In addition, in the case where there is a port 20c to which the waste liquid pipe 5 is not connected, even if a pressure gauge is set at the port 20c (or the pipe connected to the port 20c), the control unit 106 can calculate the differential pressure between the concentrator membranes.

[0540] In addition, in the filter 10 and the concentrator 20, as long as either the liquid supply side or the liquid discharge side is in a state close to being open to the atmosphere, the control unit 106 can calculate the filter membrane differential pressure and the concentrator membrane differential pressure even if only the pressure inside the tube connected to the side that is not open to the atmosphere on the liquid supply side and the liquid discharge side is measured. In other words, the control unit 106 can also control the operation of the liquid supply unit by using only the pressure inside the tube connected to the side that is not open to the atmosphere instead of the filter membrane differential pressure and the concentrator membrane differential pressure. For example, as long as the tube connected to the filter 10 and the concentrator 20 is connected to the bag and the tube is not closed by the liquid supply unit or the flow adjustment mechanism, it can be considered that the tube is in a state close to being open to the atmosphere. If it is Figure 7 In the state of, the liquid supply tube 2 connected to the original liquid bag UB among the tubes 2 and 3 connected to the filter 10 can also be regarded as open to the atmosphere. In addition, the waste liquid tube 5 connected to the waste liquid bag DB among the tubes 3 and 5 connected to the concentrator 20 can also be regarded as open to the atmosphere. Figure 7 , the control unit 106 can also control the operation of the liquid delivery unit using only the internal pressure of the filter supply pipe 3.

[0541] In addition, the flow rate of the liquid flowing in the filtrate supply pipe 3 and the concentrate pipe 4 can also be estimated based on the operation of the filtrate supply pipe liquid delivery section 3p and the concentrate pipe liquid delivery section 4p, or a flow meter can be set in the filtrate supply pipe 3 or the filtrate supply pipe liquid delivery section 3p, the concentrate pipe 4 or the concentrate pipe liquid delivery section 4p to directly measure the flow rate.

[0542] <Description of Filtration and Concentration Operation Using the Differential Pressure Between Filter and Concentrator Membranes>

[0543] In the case of a filtration and concentration operation using the differential pressure between the filter membranes and the differential pressure between the concentrator membranes, the allowable differential pressure is set in advance. That is, the differential pressure (allowable differential pressure) that the filter 10 and the concentrator 20 can allow is set according to the filter 10 and the concentrator 20, respectively. The allowable differential pressure may have a prescribed range or may be set to a specific value. In addition, the following description is based on the case where the allowable differential pressure has a prescribed range as a representative.

[0544] In addition, in the case of a filtration and concentration operation utilizing the differential pressure between the filter membrane and the differential pressure between the concentrator membrane, it is desirable to pre-set the allowable flow rate. That is, it is desirable to set the flow rate (allowable flow rate) that the raw liquid in the liquid supply pipe 2 can allow. The allowable flow rate can have a specified amplitude or be set to a specific value. The allowable flow rate does not necessarily have to be set. However, if the flow rate of the raw liquid in the liquid supply pipe 2 is too small, the time consumed for filtration and concentration becomes too long. Therefore, in order to prevent the processing time of the raw liquid from being prolonged, it is desirable to pre-set the allowable flow rate.

[0545] Furthermore, in the case of a filtration and concentration operation using the differential pressure between the filter membrane and the differential pressure between the concentrator membrane, it is desirable to pre-set the allowable concentration ratio. That is, it is desirable to set the ratio of the flow rate of the stock solution in the liquid supply pipe 2 to the flow rate of the concentrated liquid flowing in the concentrated liquid pipe 4 (the allowable concentration ratio). The allowable concentration ratio may have a specified amplitude or may be set to a specific value. The allowable concentration ratio does not necessarily have to be set. However, if the ratio of the flow rate of the stock solution in the liquid supply pipe 2 to the flow rate of the concentrated liquid flowing in the concentrated liquid pipe 4, that is, the concentration ratio, is too low (that is, the flow rate of the concentrated liquid becomes too large), the concentration efficiency deteriorates. Moreover, since the amount of concentrated liquid increases and a large amount of filtered concentrated liquid is intravenously infused again, there is a risk of causing increased blood pressure, worsening heart failure and respiratory failure, etc. Therefore, when the amount of concentrated liquid becomes excessive, additional re-concentration processing is required, and the re-concentration processing takes time. In the case of re-concentrating the concentrated liquid, since the re-concentration processing takes time, the total time used to process the stock liquid becomes longer. Therefore, in order to prevent the concentration ratio from being excessively reduced, it is desirable to set the allowable concentration ratio in advance.

[0546] At the start of filtration and concentration, the filtrate supply pipe liquid delivery section 3p is operated to increase the amount of raw liquid delivered to the filter 10. At this time, the concentrate pipe liquid delivery section 4p is operated in a manner that matches the flow rate of the filtrate in the filtrate supply pipe 3 so that the concentrate reaches a predetermined concentration ratio. For example, in the case of generating a concentrate having a concentration ratio of 10 times, the operation of the concentrate pipe liquid delivery section 4p can be adjusted so that the flow rate of the concentrate flowing in the concentrate pipe 4 reaches 1 / 10 of the flow rate of the filtrate flowing in the filtrate supply pipe 3. In addition, the operation of the concentrate pipe liquid delivery section 4p can be adjusted so that the differential pressure between the concentrator membranes becomes a set value within the allowable differential pressure (or is maintained within the allowable differential pressure) instead of the concentration ratio of the concentrate, or the differential pressure between the concentrator membranes becomes a set value within the allowable differential pressure (or is maintained within the allowable differential pressure) while the concentrate is maintained at a predetermined concentration ratio. In addition, while increasing the amount of filtrate delivered to the concentrator 20, the operation of the concentrate pipe liquid delivery section 4p is controlled so as to reach any of the above-mentioned states.

[0547] As the filtration and concentration progresses, the filter 10 and the concentrator 20 are gradually clogged. As a result, the filter membrane differential pressure and the concentrator membrane differential pressure increase. However, the filtrate supply pipe liquid delivery part 3p is operated to increase the liquid delivery amount of the filtrate to the concentrator 20 (in other words, the liquid delivery amount of the raw liquid to the filter 10) until the filter membrane differential pressure and the concentrator membrane differential pressure are within the allowable differential pressure.

[0548] <First Method>

[0549] The increase in the amount of the filtrate fed to the concentrator 20 continues until the differential pressure between the filter membranes reaches within the allowable differential pressure of the filter 10. If the differential pressure between the filter membranes is within the allowable differential pressure of the filter 10, the filtrate supply pipe feed portion 3p is controlled so that the amount of the filtrate fed to the concentrator 20 is maintained at a flow rate in a state where the differential pressure between the filter membranes reaches within the allowable differential pressure of the filter 10. On the other hand, the concentrate pipe feed portion 4p is operated to adjust the flow rate of the concentrate flowing through the concentrate pipe 4.

[0550] Here, when the differential pressure between the filter membranes is within the allowable differential pressure of the filter 10, the operation of the liquid delivery part 3p of the filtrate supply pipe is controlled in a manner to maintain the amount of liquid delivered to the concentrator 20, in other words, to maintain the amount of liquid delivered to the filter 10. In this way, the filtration using the filter 10 and the concentration using the concentrator 20 can be maintained in a specified state. In addition, if the amount of liquid delivered to the filter 10 is increased or decreased according to the value of the differential pressure between the filter membranes, the differential pressure between the filter membranes can be maintained within the allowable differential pressure of the filter 10, and the amount of liquid delivered to the filter 10 can be increased. That is, there is a possibility of improving the efficiency of the filtration and concentration operation. In particular, if the differential pressure between the filter membranes is maintained at the maximum allowable differential pressure PM of the filter 10, the amount of liquid delivered to the filter 10 can also be increased to the maximum extent, so the effect of shortening the time of the filtration operation can be further improved.

[0551] On the other hand, if the differential pressure between the filter membranes becomes greater than the maximum allowable differential pressure PM of the filter 10, the operation of the liquid supply part 3p of the filtrate supply pipe is controlled so that the amount of liquid delivered to the filter 10 is reduced. In the case where the hollow fiber membrane is blocked even if the amount of liquid delivered to the filter 10 is constant, there is a possibility that the differential pressure between the filter membranes becomes larger and the filtration cannot be continued. However, if the amount of liquid delivered to the filter 10 is reduced, the differential pressure between the filter membranes can be reduced, so the filtration operation can be continued even if the filter 10 is blocked. In addition, there is a possibility that the clogging of the hollow fiber membrane 16 can be slightly reduced due to the reduction in the amount of liquid delivered to the filter 10, so there is a possibility that it becomes easy to continue the filtration operation and the time of the filtration operation can be shortened. In particular, when the differential pressure between the filter membranes becomes greater than the maximum allowable differential pressure PM of the filter 10, as long as the liquid delivery of the raw liquid to the filter 10 is temporarily stopped and the supply is restarted after a certain period of time, there is a possibility that the effect of reducing the clogging of the hollow fiber membrane, etc. can be improved.

[0552] In addition, when the differential pressure between the filter membranes becomes less than the minimum allowable differential pressure PL of the filter 10 due to the reduction of the amount of liquid delivered to the filter 10, the operation of the liquid delivery portion 3p of the filtrate supply pipe is controlled so that the amount of liquid delivered to the filter 10 is increased. As a result, since the filtration amount of the filter 10 can be increased, there is a possibility of shortening the time of the filtration operation. In addition, if the amount of liquid delivered to the filter 10 is increased until the differential pressure between the filter membranes reaches the allowable differential pressure of the filter 10, the filtration capacity of the filter 10 can be effectively used, so the effect of shortening the time of the filtration operation can be further improved.

[0553] In addition, when the differential pressure between the filter membranes becomes greater than the maximum allowable differential pressure PM of the filter 10, the amount of liquid delivered to the filter 10 may be reduced, the amount of liquid delivered may be reduced gradually, or the amount of liquid delivered may be reduced in a stepwise manner. Fig.24 In the case of PM), the feeding of the raw liquid to the filter 10 may be stopped for a certain period of time and then the feeding of the raw liquid to the filter 10 may be started (see Fig.24 ). In this case, it is sufficient to adjust the amount of the raw liquid delivered to the filter 10 while confirming the differential pressure between the filter membranes. Fig.24 As shown in mode 1, when the supply of the raw liquid to the filter 10 is stopped for a certain period of time and then the supply of the raw liquid to the filter 10 is started, the supply is first started at a flow rate of about 1 / 2 of the maximum allowable flow rate LM and the differential pressure between the filter membranes at this time is confirmed. If the differential pressure between the filter membranes is less than the minimum allowable differential pressure PL ( Fig.24 PL), then increase the flow rate by about 1 / 2 of the difference between the current flow rate and the maximum allowable flow rate LM and confirm the differential pressure between the filter membranes at this time. If the differential pressure between the filter membranes is still less than the minimum allowable differential pressure PL in this state, further increase the flow rate by about 1 / 2 of the difference between the current flow rate and the maximum allowable flow rate LM and confirm the differential pressure between the filter membranes at this time. Repeat this operation, and if the differential pressure between the filter membranes is above the minimum allowable differential pressure PL of the filter 10 and below the maximum allowable differential pressure PM (or if the maximum allowable differential pressure PM is reached), stop increasing the flow rate. In addition, even if the differential pressure between the filter membranes is above the minimum allowable differential pressure PL of the filter 10 and below the maximum allowable differential pressure PM, if the maximum allowable flow rate LM is not reached, the amount of raw liquid delivered to the filter 10 can be increased in the same way while confirming the differential pressure between the filter membranes until it reaches the maximum allowable flow rate LM.

[0554] When the flow rate of the raw liquid to the filter 10 is increased when the differential pressure between the filter membranes becomes smaller than the minimum allowable differential pressure PL of the filter 10, the flow rate of the raw liquid may be gradually increased. For example, the flow rate may be increased by the same method as the above-mentioned flow rate increasing method, i.e., the flow rate is increased from a state where the flow rate of the raw liquid to the filter 10 is stopped for a certain period of time.

[0555] In addition, when the differential pressure between the filter membranes is maintained within the allowable differential pressure of the filter 10, it is sufficient to maintain the amount of raw liquid delivered to the filter 10. However, when the flow rate is less than the maximum allowable flow rate LM, the amount of raw liquid delivered to the filter 10 can also be increased until the maximum allowable flow rate LM is reached.

[0556] Even if the differential pressure between the filter membranes reaches or exceeds the minimum allowable differential pressure PL of the filter 10, if the amount of raw liquid delivered to the filter 10 does not reach the minimum allowable flow rate LL ( Fig.24 In mode 3), it can also be determined that clogging of the hollow fiber membrane 16 or the like has occurred, so the filtration and concentration operation is terminated and the operation is transferred to the cleaning operation.

[0557] Next, when the filter inter-membrane pressure difference is within the allowable pressure difference of the filter 10 and the flow rate of the raw liquid in the liquid supply pipe 2 is maintained at a flow rate at which the filter inter-membrane pressure difference 10 reaches the allowable pressure difference of the filter 10, the concentrated liquid pipe liquid supply section 4p can be controlled as follows based on the concentrator inter-membrane pressure difference.

[0558] <Step 1>

[0559] First, when the differential pressure between the concentrator membranes is less than the minimum allowable differential pressure of the concentrator 20, the concentrated liquid pipe feeder 4p is operated to reduce the amount of concentrated liquid delivered to the concentrated liquid bag CB. That is, the operation of the concentrated liquid pipe feeder 4p is controlled to increase the concentration of the concentrated liquid.

[0560] <Step 2>

[0561] Then, the amount of concentrate delivered to the concentrate bag CB is reduced until the differential pressure between the concentrator membranes reaches within the allowable differential pressure of the concentrator 20. If the differential pressure between the concentrator membranes reaches within the allowable differential pressure of the concentrator 20, the concentrate pipe delivery section 4p is controlled so that the flow rate of the concentrate in the concentrate pipe 4 is maintained at a flow rate in a state where the differential pressure between the concentrator membranes reaches within the allowable differential pressure of the concentrator 20.

[0562] <Step 3>

[0563] If the differential pressure between the concentrator membranes becomes greater than the maximum allowable ...

Claims

1. A method for cleaning an apparatus having a hollow fiber membrane, the apparatus comprising: The main body has a hollow space inside; the hollow fiber membrane is arranged in the hollow space of the main body. The cleaning method is characterized in that When cleaning the hollow fiber membranes in the device, liquid is flowed in such a manner that the liquid passes through the hollow fiber membranes while the hollow space of the main body and / or the hollow fiber membranes are filled with the liquid until the area to be cleaned in the hollow fiber membranes is completely filled.

2. The method for cleaning a device having a hollow fiber membrane according to claim 1, characterized in that: When cleaning the hollow fiber membrane in the device, liquid is flowed in the following manner: after the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the area to be cleaned in the hollow fiber membrane is completely filled, the liquid is passed through the hollow fiber membrane.

3. The method for cleaning a device having a hollow fiber membrane according to claim 1 or 2, characterized in that: The apparatus comprises: a first liquid supply part, which is in communication with the first end of the hollow fiber membrane and supplies the exhaust fluid between the inside and the outside of the hollow fiber membrane; a second liquid supply part, which is in communication with the second end of the hollow fiber membrane and supplies the exhaust fluid between the inside and the outside of the hollow fiber membrane; A port for supplying a discharge fluid between the hollow space of the main body and the outside, In a state where the axial direction of the hollow fiber membrane is arranged to be oriented in the vertical direction, The liquid is caused to flow in such a manner that the hollow space of the main body and / or the hollow fiber membrane is filled with the liquid until the hollow fiber membrane is entirely or partially immersed in the liquid, and the liquid is allowed to permeate the hollow fiber membrane in this state.

4. The method for cleaning a device having a hollow fiber membrane according to claim 1 or 2, characterized in that: The apparatus comprises: a first liquid supply part, which is in communication with the first end of the hollow fiber membrane and supplies the exhaust fluid between the inside and the outside of the hollow fiber membrane; a second liquid supply part, which is in communication with the second end of the hollow fiber membrane and supplies the exhaust fluid between the inside and the outside of the hollow fiber membrane; A port for supplying a discharge fluid between the hollow space of the main body and the outside, When the hollow fiber membrane is configured in a manner such that its axial direction is oriented horizontally, the liquid is caused to flow in the following manner: the liquid fills the hollow space of the main body and / or the hollow fiber membrane until the hollow fiber membrane is entirely or partially immersed in the liquid, and the liquid passes through the hollow fiber membrane in this state.

5. The method for cleaning a device having a hollow fiber membrane according to any one of claims 1, 2, 3 or 4, characterized in that: The apparatus comprises: a first liquid supply part, which is in communication with the first end of the hollow fiber membrane and supplies the exhaust fluid between the inside and the outside of the hollow fiber membrane; a second liquid supply part, which is in communication with the second end of the hollow fiber membrane and supplies the exhaust fluid between the inside and the outside of the hollow fiber membrane; A port for supplying a discharge fluid between the hollow space of the main body and the outside, When liquid is supplied from the port, liquid is discharged from the first liquid supply part and / or the second liquid supply part, or when liquid is supplied from the first liquid supply part and / or the second liquid supply part, liquid is discharged from the port.

6. A method for operating a stock solution treatment device, which is a method for operating a device for concentrating a stock solution to form a concentrated solution, characterized in that: The device has: A filter having a filtering component for filtering the raw liquid; a concentrator supplied with the filtrate filtered by the filter and concentrating the filtrate to form the concentrate; A raw liquid supply unit supplies the raw liquid to the filter; A liquid supply passage, connecting the stock liquid supply part with the stock liquid supply port of the filter; a filtrate supply flow path connecting the filtrate discharge port of the filter with the filtrate supply port of the concentrator; a concentrate flow path connected to a concentrate discharge port of the concentrator; a waste liquid flow path connected to a waste liquid discharge port, the waste liquid discharge port discharges the waste liquid separated from the concentrated liquid in the concentrator; The liquid delivery section delivers liquid to each flow path; A control unit controls the operation of the liquid delivery unit. The filter and / or the concentrator has: A main body portion having a hollow space inside; The hollow fiber membrane is arranged in the hollow space of the main body. When cleaning the hollow fiber membrane in the filter and / or the concentrator, the control unit controls the operation of the liquid supply unit so that liquid passes through the hollow fiber membrane while the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the area to be cleaned in the hollow fiber membrane is filled.

7. The method for operating the raw liquid treatment device according to claim 6, characterized in that: When cleaning the hollow fiber membrane in the filter and / or the concentrator, the control unit controls the operation of the liquid supply unit so that the liquid passes through the hollow fiber membrane after the hollow space in the main body and / or the hollow fiber membrane is filled with liquid until the area to be cleaned in the hollow fiber membrane is filled.

8. The method for operating a raw liquid treatment device according to claim 6 or 7, characterized in that: The filter is arranged so that the axial direction of the hollow fiber membrane is oriented in the vertical direction. The filter has a port, which is arranged above the raw liquid supply port or the filtrate discharge port when the hollow fiber membrane in the filter is cleaned, and can connect the hollow space in the main body with the outside. The control unit controls the operation of the liquid supply unit so that the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the hollow fiber membrane is completely or partially immersed in the liquid, and the liquid passes through the hollow fiber membrane of the filter in this state.

9. The method for operating a raw liquid treatment device according to any one of claims 6, 7 or 8, characterized in that: The concentrator is arranged so that the axial direction of the hollow fiber membrane is oriented in the vertical direction. The concentrator includes a port, which is arranged above the concentrate outlet or the waste liquid outlet when the hollow fiber membrane in the concentrator is cleaned, and can connect the hollow space in the main body with the outside. The control unit controls the operation of the liquid delivery unit so that the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the hollow fiber membrane is entirely or partially immersed in the liquid, and the liquid passes through the hollow fiber membrane of the concentrator in this state.

10. The method for operating a raw liquid treatment device according to claim 6 or 7, characterized in that: In a state where the filter and / or the concentrator is arranged so that the axial direction of the hollow fiber membrane is oriented in a horizontal direction, The control unit controls the operation of the liquid supply unit so that the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the hollow fiber membrane is entirely or partially immersed in the liquid, and the liquid passes through the hollow fiber membrane in this state.

11. The method for operating a raw liquid treatment device according to any one of claims 6, 7, 8, 9 or 10, characterized in that: A liquid is supplied into the concentrator from the filtrate supply port or the concentrated liquid discharge port.

12. A method for operating a raw liquid processing device, which is a method for operating a device for concentrating raw liquid to form a concentrated liquid, characterized in that: The device has: A filter having a filtering component for filtering the raw liquid; a concentrator supplied with the filtrate filtered by the filter and concentrating the filtrate to form the concentrate; A raw liquid supply unit supplies the raw liquid to the filter; A liquid supply passage, connecting the stock liquid supply part with the stock liquid supply port of the filter; a filtrate supply flow path connecting the filtrate discharge port of the filter with the filtrate supply port of the concentrator; a concentrate flow path connected to a concentrate discharge port of the concentrator; a waste liquid flow path connected to a waste liquid discharge port, the waste liquid discharge port discharges the waste liquid separated from the concentrated liquid in the concentrator; The liquid delivery section delivers liquid to each flow path; A control unit controls the operation of the liquid delivery unit. The amount of liquid sent from the filter to the concentrator and / or the concentration ratio of the concentrated liquid are adjusted based on the differential pressure between filter membranes of the filter and / or the differential pressure between concentrator membranes of the concentrator.

13. The method for operating a raw liquid treatment device according to claim 12, characterized in that: The liquid delivery part has: A liquid supply channel liquid delivery portion provided in the liquid supply channel; a concentrated liquid flow path liquid feeding section provided in the concentrated liquid flow path or a waste liquid flow path liquid feeding section provided in the waste liquid flow path, When the differential pressure between the filter membranes is lower than the set differential pressure of the filter, the amount of the raw liquid sent to the filter is increased, When the differential pressure between the filter membranes is within the set differential pressure range of the filter, the amount of the raw liquid delivered to the filter is maintained; When the differential pressure between the filter membranes is greater than the set differential pressure of the filter, the amount of the raw liquid sent to the filter is reduced.

14. The method for operating a raw liquid treatment device according to claim 12 or 13, characterized in that: The liquid delivery part has: A liquid supply channel liquid delivery portion provided in the liquid supply channel; a concentrated liquid flow path liquid feeding section provided in the concentrated liquid flow path or a waste liquid flow path liquid feeding section provided in the waste liquid flow path, When the differential pressure between the concentrator membranes of the concentrator is lower than the set differential pressure, the amount of liquid sent from the filter to the concentrator is increased, When the differential pressure between the concentrator membranes of the concentrator is within a set differential pressure range, the amount of liquid sent from the filter to the concentrator is maintained, When the differential pressure between the concentrator membranes of the concentrator is greater than the set differential pressure, the amount of liquid sent from the filter to the concentrator is reduced.

15. The method for operating a raw liquid treatment device according to any one of claims 12, 13 or 14, characterized in that: The liquid delivery part has: A liquid supply channel liquid delivery portion provided in the liquid supply channel; a concentrated liquid flow path liquid feeding section provided in the concentrated liquid flow path or a waste liquid flow path liquid feeding section provided in the waste liquid flow path, When the differential pressure between the concentrator membranes of the concentrator is less than the set differential pressure, the flow rate of the concentrated liquid flow path is reduced or the flow rate of the waste liquid flow path is increased, When the differential pressure between the concentrator membranes of the concentrator is within a set differential pressure range, the flow rates of the concentrate flow path and the waste liquid flow path are maintained; When the differential pressure between the concentrator membranes of the concentrator is greater than the set differential pressure, the flow rate of the concentrate flow path is increased or the flow rate of the waste liquid flow path is reduced.

16. The method for operating a raw liquid treatment device according to claim 12, characterized in that: The liquid delivery part has: a filtrate supply flow path liquid delivery portion disposed in the filtrate supply flow path; a concentrated liquid flow path liquid feeding section provided in the concentrated liquid flow path or a waste liquid flow path liquid feeding section provided in the waste liquid flow path, When the differential pressure between the filter membranes is smaller than the set differential pressure of the filter, the amount of filtrate sent to the concentrator is increased, When the differential pressure between the filter membranes is within the set differential pressure range of the filter, the amount of filtrate fed to the concentrator is maintained; When the differential pressure between the filter membranes is greater than the set differential pressure of the filter, the amount of filtrate sent to the concentrator is reduced.

17. The method for operating a raw liquid treatment device according to claim 12 or 16, characterized in that: The liquid delivery part has: a filtrate supply flow path liquid delivery portion disposed in the filtrate supply flow path; a concentrated liquid flow path liquid feeding section provided in the concentrated liquid flow path or a waste liquid flow path liquid feeding section provided in the waste liquid flow path, When the differential pressure between the concentrator membranes is lower than the set differential pressure of the concentrator, the amount of concentrated liquid delivered to the concentrated liquid flow path is reduced or the amount of waste liquid delivered to the waste liquid flow path is increased, When the differential pressure between the concentrator membranes is within the range of the set differential pressure of the concentrator, the concentrated liquid in the concentrated liquid flow path and the liquid delivery amount in the waste liquid flow path are maintained; When the differential pressure between the concentrator membranes is greater than the set differential pressure of the concentrator, the amount of concentrated liquid sent through the concentrated liquid flow path is increased or the amount of waste liquid sent through the waste liquid flow path is reduced.

18. The method for operating a raw liquid treatment device according to any one of claims 12, 16 or 17, characterized in that: The liquid delivery part has: a filtrate supply flow path liquid delivery portion disposed in the filtrate supply flow path; a concentrated liquid flow path liquid feeding section provided in the concentrated liquid flow path or a waste liquid flow path liquid feeding section provided in the waste liquid flow path, When the differential pressure between the membranes of the concentrator is lower than the set differential pressure of the concentrator, the amount of filtrate delivered to the concentrator is increased. When the differential pressure between the concentrator membranes is within the range of the set differential pressure of the concentrator, the amount of filtrate fed to the concentrator is maintained; When the differential pressure between the concentrator membranes is greater than the set differential pressure of the concentrator, the amount of filtrate sent to the concentrator is reduced.

19. The method for operating a raw liquid treatment device according to claim 12, characterized in that: The liquid delivery part has: a concentrated liquid flow path liquid delivery portion disposed in the concentrated liquid flow path; A waste liquid flow channel liquid delivery section provided in the waste liquid flow channel, When the differential pressure between the filter membranes is lower than the set differential pressure of the filter, the liquid delivery rate of the concentrated liquid and / or the liquid delivery rate of the waste liquid is increased, When the differential pressure between the filter membranes is within the set differential pressure range of the filter, the liquid delivery rate of the concentrated liquid and / or the liquid delivery rate of the waste liquid is maintained, When the differential pressure between the filter membranes is greater than the set differential pressure of the filter, the amount of the concentrated liquid and / or the amount of the waste liquid sent is reduced.

20. The method for operating a raw liquid treatment device according to claim 12 or 19, characterized in that: The liquid delivery part has: a concentrated liquid flow path liquid delivery portion disposed in the concentrated liquid flow path; A waste liquid flow channel liquid delivery section provided in the waste liquid flow channel, When the differential pressure between the concentrator membranes is lower than the set differential pressure of the concentrator, the amount of concentrated liquid delivered to the concentrated liquid flow path is reduced and / or the amount of waste liquid delivered to the waste liquid flow path is increased, When the differential pressure between the concentrator membranes is within the range of the set differential pressure of the concentrator, the delivery rate of the concentrated liquid in the concentrated liquid flow path and / or the delivery rate of the waste liquid in the waste liquid flow path are maintained, When the differential pressure between the concentrator membranes is greater than the set differential pressure of the concentrator, the amount of concentrated liquid sent through the concentrated liquid flow path is increased and / or the amount of waste liquid sent through the waste liquid flow path is reduced.

21. The method for operating a raw liquid treatment device according to any one of claims 12 to 20, characterized in that: A concentrated liquid container containing concentrated liquid is connected to the concentrated liquid flow path, and a flow path is provided for supplying the concentrated liquid in the concentrated liquid container from the concentrated liquid container to the filtrate supply port of the concentrator. The concentrated liquid is fed so as to flow from the concentrated liquid container to the filtrate supply port of the concentrator.

22. The method for operating a raw liquid treatment device according to any one of claims 12 to 21, characterized in that: When the filtrate and / or the concentrated liquid in the device is recovered, a gas or a liquid is supplied to the filter.

23. The method for operating a raw liquid treatment device according to claim 22, characterized in that: When the concentrated liquid in the concentrator is recovered after the filtrate in the filter is recovered, If the differential pressure between the concentrator membranes of the concentrator is greater than the set differential pressure, the liquid supply from the filter to the concentrator is stopped.

24. The method for operating a raw liquid treatment device according to claim 23, characterized in that: After the liquid supply from the filter to the concentrator is stopped, a gas is supplied to the filtrate supply flow path.

25. The method for operating a raw liquid treatment device according to any one of claims 12 to 24, characterized in that: The filter has: The main body has a hollow space inside: The hollow fiber membrane is arranged in the hollow space of the main body. The filter is arranged so as to supply the stock solution into the hollow fiber membrane or the hollow space of the main body. When cleaning the hollow fiber membrane of the filter, The liquid in the hollow space of the main body of the filter or in the hollow fiber membrane is discharged while air and / or cleaning liquid is supplied to the hollow space of the main body of the filter or in the hollow fiber membrane, or the liquid in the hollow space and in the hollow fiber membrane is discharged while air and / or cleaning liquid is supplied to the hollow space of the main body of the filter and in the hollow fiber membrane, Then, the cleaning liquid is supplied to the hollow space of the main body and / or the hollow fiber membrane in such a way that the cleaning liquid passes through the hollow fiber membrane and the hollow fiber membrane, or the cleaning liquid is supplied to the hollow fiber membrane in such a way that the cleaning liquid passes through the hollow fiber membrane, or the cleaning liquid is supplied to the hollow space of the main body in such a way that the cleaning liquid passes through the hollow space of the main body.

26. The method for operating a raw liquid treatment device according to claim 25, characterized in that: When the filter discharges the liquid in the hollow space and / or the hollow fiber membrane, Air and / or a cleaning liquid are pressurized and supplied into the hollow space and / or the hollow fiber membranes, and / or liquid in the hollow space and / or the hollow fiber membranes is discharged by negative pressure.

27. The method for operating a raw liquid treatment device according to claim 25 or 26, characterized in that: When the filter supplies air and / or a cleaning liquid into the hollow space of the main body and / or into the hollow fiber membrane, Air and / or a cleaning liquid are pressurized and supplied into the hollow space and / or into the hollow fiber membranes, and / or the hollow space and / or into the hollow fiber membranes are set to a negative pressure.

28. A raw liquid processing device is a device for concentrating raw liquid to form concentrated liquid, characterized in that: have: A filter having a filtering component for filtering the raw liquid; a concentrator supplied with the filtrate filtered by the filter and concentrating the filtrate to form the concentrate; A raw liquid supply unit supplies the raw liquid to the filter; A liquid supply passage, connecting the stock liquid supply part with the stock liquid supply port of the filter; a filtrate supply flow path connecting the filtrate discharge port of the filter with the filtrate supply port of the concentrator; a concentrate flow path connected to a concentrate discharge port of the concentrator; a waste liquid flow path connected to a waste liquid discharge port, the waste liquid discharge port discharges the waste liquid separated from the concentrated liquid in the concentrator; The liquid delivery section delivers liquid to each flow path; A control unit controls the operation of the liquid delivery unit. The filter and / or the concentrator has: A main body portion having a hollow space inside; The hollow fiber membrane is arranged in the hollow space of the main body. When cleaning the hollow fiber membrane in the filter and / or the concentrator, the control unit controls the operation of the liquid supply unit so that liquid passes through the hollow fiber membrane while the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the area to be cleaned in the hollow fiber membrane is filled.

29. The raw liquid processing device according to claim 28, characterized in that: When cleaning the hollow fiber membrane in the filter and / or the concentrator, the control unit controls the operation of the liquid supply unit so that the liquid passes through the hollow fiber membrane after the hollow space in the main body and / or the hollow fiber membrane is filled with liquid until the area to be cleaned in the hollow fiber membrane is filled.

30. The raw liquid treatment device according to claim 28 or 29, characterized in that: The filter is arranged so that the axial direction of the hollow fiber membrane is oriented in the vertical direction. The filter has a port, which is arranged above the raw liquid supply port or the filtrate discharge port when the hollow fiber membrane in the filter is cleaned, and can connect the hollow space in the main body with the outside. The control unit controls the operation of the liquid feeding unit so that the liquid is allowed to pass through the hollow fiber membranes of the filter while the hollow space of the main body and / or the hollow fiber membranes are filled with the liquid.

31. The raw liquid treatment device according to any one of claims 28, 29 or 30, characterized in that: The concentrator is arranged so that the axial direction of the hollow fiber membrane is oriented in the vertical direction. The concentrator includes a port, which is arranged above the concentrate outlet or the waste liquid outlet when the hollow fiber membrane in the concentrator is cleaned, and can connect the hollow space in the main body with the outside. The control unit controls the operation of the liquid delivery unit so that the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the hollow fiber membrane is entirely or partially immersed in the liquid, and the liquid passes through the hollow fiber membrane of the concentrator in this state.

32. The raw liquid treatment device according to claim 28 or 29, characterized in that: In a state where the filter and / or the concentrator is arranged so that the axial direction of the hollow fiber membrane is oriented in a horizontal direction, The control unit controls the operation of the liquid supply unit so that the hollow space of the main body and / or the hollow fiber membrane is filled with liquid until the hollow fiber membrane is entirely or partially immersed in the liquid, and the liquid passes through the hollow fiber membrane in this state.

33. A raw liquid processing device is a device for concentrating raw liquid to form concentrated liquid, characterized in that: The device has: A filter having a filtering component for filtering the raw liquid; a concentrator supplied with the filtrate filtered by the filter and concentrating the filtrate to form the concentrate; A raw liquid supply unit supplies the raw liquid to the filter; A liquid supply passage, connecting the stock liquid supply part with the stock liquid supply port of the filter; a filtrate supply flow path connecting the filtrate discharge port of the filter with the filtrate supply port of the concentrator; a concentrate flow path connected to a concentrate discharge port of the concentrator; a waste liquid flow path connected to a waste liquid discharge port, the waste liquid discharge port discharges the waste liquid separated from the concentrated liquid in the concentrator; The liquid delivery section delivers liquid to each flow path; A control unit controls the operation of the liquid delivery unit. The control unit controls the operation of the liquid supply unit based on the filter membrane differential pressure of the filter and / or the concentrator membrane differential pressure of the concentrator to adjust the liquid supply amount from the filter to the concentrator and / or the concentration ratio of the concentrated liquid.

34. The raw liquid processing device according to claim 33, characterized in that: The liquid delivery unit has: A liquid supply channel liquid delivery portion provided in the liquid supply channel; a concentrated liquid flow path liquid feeding section provided in the concentrated liquid flow path or a waste liquid flow path liquid feeding section provided in the waste liquid flow path, The control unit controls the operation of the liquid delivery unit in the following manner: When the differential pressure between the filter membranes is lower than the set differential pressure of the filter, the amount of the raw liquid sent to the filter is increased, When the differential pressure between the filter membranes is within the set differential pressure range of the filter, the amount of the raw liquid delivered to the filter is maintained; When the differential pressure between the filter membranes is greater than the set differential pressure of the filter, the amount of the raw liquid sent to the filter is reduced.

35. The raw liquid treatment device according to claim 33 or 34, characterized in that: The liquid delivery unit has: A liquid supply channel liquid delivery portion provided in the liquid supply channel; a concentrated liquid flow path liquid feeding section provided in the concentrated liquid flow path or a waste liquid flow path liquid feeding section provided in the waste liquid flow path, The control unit controls the operation of the liquid delivery unit in the following manner: When the differential pressure between the concentrator membranes of the concentrator is lower than the set differential pressure, the amount of liquid sent from the filter to the concentrator is increased, When the differential pressure between the concentrator membranes of the concentrator is within a set differential pressure range, the amount of liquid sent from the filter to the concentrator is maintained, When the differential pressure between the concentrator membranes of the concentrator is greater than the set differential pressure, the amount of liquid sent from the filter to the concentrator is reduced.

36. The raw liquid treatment device according to any one of claims 33, 34 or 35, characterized in that: The liquid delivery unit has: A liquid supply channel liquid delivery portion provided in the liquid supply channel; a concentrated liquid flow path liquid feeding section provided in the concentrated liquid flow path or a waste liquid flow path liquid feeding section provided in the waste liquid flow path, The control unit controls the operation of the liquid delivery unit in the following manner: When the differential pressure between the concentrator membranes of the concentrator is less than the set differential pressure, the flow rate of the concentrated liquid flow path is reduced or the flow rate of the waste liquid flow path is increased, When the differential pressure between the concentrator membranes of the concentrator is within a set differential pressure range, the flow rates of the concentrate flow path and the waste liquid flow path are maintained; When the differential pressure between the concentrator membranes of the concentrator is greater than the set differential pressure, the flow rate of the concentrate flow path is increased or the flow rate of the waste liquid flow path is reduced.

37. The raw liquid treatment device according to claim 33, characterized in that: The liquid delivery unit has: a filtrate supply flow path liquid delivery portion disposed in the filtrate supply flow path; a concentrated liquid flow path liquid feeding section provided in the concentrated liquid flow path or a waste liquid flow path liquid feeding section provided in the waste liquid flow path, The control unit controls the operation of the liquid delivery unit in the following manner: When the differential pressure between the filter membranes is lower than the set differential pressure of the filter, the amount of filtrate sent to the concentrator is increased, When the differential pressure between the filter membranes is within the set differential pressure range of the filter, the amount of filtrate fed to the concentrator is maintained; When the differential pressure between the filter membranes is greater than the set differential pressure of the filter, the amount of filtrate sent to the concentrator is reduced.

38. The raw liquid treatment device according to claim 33 or 37, characterized in that: The liquid delivery unit has: a filtrate supply flow path liquid delivery portion disposed in the filtrate supply flow path; a concentrated liquid flow path liquid feeding section provided in the concentrated liquid flow path or a waste liquid flow path liquid feeding section provided in the waste liquid flow path, The control unit controls the operation of the liquid delivery unit in the following manner: When the differential pressure between the concentrator membranes is lower than the set differential pressure of the concentrator, the amount of concentrated liquid delivered to the concentrated liquid flow path is reduced or the amount of waste liquid delivered to the waste liquid flow path is increased, When the differential pressure between the concentrator membranes is within the range of the set differential pressure of the concentrator, the delivery rate of the concentrated liquid in the concentrated liquid flow path and the delivery rate of the waste liquid in the waste liquid flow path are maintained, When the differential pressure between the concentrator membranes is greater than the set differential pressure of the concentrator, the amount of concentrated liquid sent through the concentrated liquid flow path is increased or the amount of waste liquid sent through the waste liquid flow path is reduced.

39. The raw liquid treatment device according to any one of claims 33, 37 or 38, characterized in that: The liquid delivery unit has: a filtrate supply flow path liquid delivery portion disposed in the filtrate supply flow path; a concentrated liquid flow path liquid feeding section provided in the concentrated liquid flow path or a waste liquid flow path liquid feeding section provided in the waste liquid flow path, The control unit controls the operation of the liquid delivery unit in the following manner: When the differential pressure between the membranes of the concentrator is lower than the set differential pressure of the concentrator, the amount of filtrate delivered to the concentrator is increased. When the differential pressure between the concentrator membranes is within the range of the set differential pressure of the concentrator, the amount of filtrate fed to the concentrator is maintained; When the differential pressure between the concentrator membranes is greater than the set differential pressure of the concentrator, the amount of filtrate sent to the concentrator is reduced.

40. The raw liquid treatment device according to claim 33, characterized in that: The liquid delivery unit has: a concentrated liquid flow path liquid delivery portion disposed in the concentrated liquid flow path; A waste liquid flow channel liquid delivery section provided in the waste liquid flow channel, The control unit controls the operation of the liquid delivery unit in the following manner: When the differential pressure between the filter membranes is lower than the set differential pressure of the filter, the amount of the concentrated liquid delivered is increased and / or the amount of the waste liquid delivered is reduced, When the differential pressure between the filter membranes is within the set differential pressure range of the filter, the liquid delivery rate of the concentrated liquid and the liquid delivery rate of the waste liquid are maintained, When the differential pressure between the filter membranes is greater than the set differential pressure of the filter, the amount of the concentrated liquid sent is reduced and / or the amount of the waste liquid sent is increased.

41. The raw liquid treatment device according to claim 33 or 40, characterized in that: The liquid delivery unit has: a concentrated liquid flow path liquid delivery portion disposed in the concentrated liquid flow path; A waste liquid flow channel liquid delivery section provided in the waste liquid flow channel, The control unit controls the operation of the liquid delivery unit in the following manner: When the differential pressure between the concentrator membranes is lower than the set differential pressure of the concentrator, the amount of concentrated liquid delivered to the concentrated liquid flow path is reduced and / or the amount of waste liquid delivered to the waste liquid flow path is increased, When the differential pressure between the concentrator membranes is within the range of the set differential pressure of the concentrator, the delivery rate of the concentrated liquid in the concentrated liquid flow path and / or the delivery rate of the waste liquid in the waste liquid flow path are maintained, When the differential pressure between the concentrator membranes is greater than the set differential pressure of the concentrator, the amount of concentrated liquid sent through the concentrated liquid flow path is increased and / or the amount of waste liquid sent through the waste liquid flow path is reduced.

42. The raw liquid treatment device according to any one of claims 33 to 41, characterized in that: A concentrated liquid container containing concentrated liquid is connected to the concentrated liquid flow path, and a flow path is provided for supplying the concentrated liquid in the concentrated liquid container from the concentrated liquid container to the filtrate supply port of the concentrator. The control unit controls the operation of the liquid feeding unit so that the concentrated liquid flows from the concentrated liquid container to the filtrate supply port of the concentrator.

43. The raw liquid treatment device according to any one of claims 33 to 42, characterized in that: The control unit supplies gas or liquid to the filter when performing an operation of recovering the filtrate in the filter.

44. The raw liquid processing device according to claim 43, characterized in that: When the control unit recovers the filtrate in the filter and then recovers the concentrated liquid in the concentrator, When the differential pressure between the concentrator membranes of the concentrator is greater than a set differential pressure, the operation of the liquid feeding unit is controlled to stop the liquid feeding from the filter to the concentrator.

45. The raw liquid processing device according to claim 44, characterized in that: A gas supply unit is provided to supply gas to the filtrate supply flow path, The control unit controls the operation of the liquid supply unit to stop the liquid supply from the filter to the concentrator, and then controls the operation of the gas supply unit to supply gas to the filtrate supply flow path.

46. ​​The raw liquid treatment device according to any one of claims 28 to 45, characterized in that: The liquid delivery unit is a roller pump device, which includes a roller with a tube arranged between the roller and the support. The liquid delivery unit includes a tube positioning member for holding the tube wound around the roller of the roller pump device. The tube positioning member comprises: a pair of holding members, arranged at intervals along the axial direction of the tube; The connecting member maintains the pair of holding members in a state where they are separated by a predetermined distance in the axial direction of the tube. A plurality of tube holding parts for holding a plurality of tubes are arranged in a row on each of the holding members. The plurality of tube holding portions are configured such that: If the plurality of tubes are arranged so that the same tube is held by the corresponding tube holding portions in the pair of holding members, the plurality of tubes are parallel to each other. The connecting member is formed as follows: Between the pair of holding members, the plurality of tube holding portions can be bent in a direction intersecting with the direction in which the plurality of tube holding portions are arranged and the axial direction of the plurality of tubes held by the plurality of tube holding portions. In a state where the connection member is extended, the plurality of tubes held by the plurality of tube holding portions are arranged so that the axial directions of the plurality of tubes are parallel to the longitudinal direction of the connection member.

47. The raw liquid processing device according to claim 46, characterized in that: The connecting component is arranged in such a manner that, when the connecting component is extended, the connecting component is located between adjacent tubes held by the multiple tube holding portions when viewed from the direction in which the multiple tube holding portions are arranged and from a direction intersecting with the axial directions of the multiple tubes held by the multiple tube holding portions.

48. The raw liquid treatment device according to claim 46 or 47, characterized in that: The connecting member is arranged in the following manner: The plurality of tube holding portions are offset from the central axes of the plurality of tubes held by the plurality of tube holding portions in a direction in which the plurality of tube holding portions are arranged and in a direction intersecting the axial directions of the plurality of tubes held by the plurality of tube holding portions.

49. The raw liquid treatment device according to any one of claims 46, 47 or 48, characterized in that: The pair of holding members are formed in an asymmetric shape with respect to a line bisecting the holding members in the direction in which the plurality of tube holding portions are arranged.

50. The raw liquid treatment device according to any one of claims 46, 47, 48 or 49, characterized in that: The control unit has a function of causing the roller to rotate forward or reverse when a pipe is arranged between the bracket and the roller.

51. The raw liquid processing device according to claim 50, characterized in that: The control unit has a function of sending an abnormality alarm when the rotation resistance reaches a predetermined value or more when the roller is rotated forward or reversely.

52. The raw liquid treatment device according to claim 50 or 51, characterized in that: The roller pump device includes a pair of accommodating portions, a pair of holding members of the tube positioning member being arranged therein, The pair of accommodation portions are provided at positions sandwiching a surface including the rotation axis of the roller.

53. The raw liquid treatment device according to any one of claims 28 to 53, characterized in that: A pipe support for holding the pipe is provided, And have: Main body; A plurality of holding parts are provided on the first surface of the main body and are capable of holding a plurality of tubes in a detachable manner; A connecting part connects the main body to other equipment. The plurality of holding portions are arranged so that, when the plurality of tubes are held by the plurality of holding portions, axial directions of the plurality of tubes are parallel to each other and the plurality of tubes are arranged along the surface of the first surface of the main body.

54. The raw liquid processing device according to claim 53, characterized in that: The connecting portion includes an engaging member protruding toward a second surface side located on the opposite side of the first surface of the main body or protruding toward the first surface side, The engaging member has an opening formed at one end and a gap continuous with the opening.

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