Amplified preparation process of high-performance protein-like fiber

Abstract

The invention discloses a large-scale preparation process of high-performance protein-like fibers, which comprises the following steps: S1, dissolving protein-like particles in a solvent, stirring until the protein-like particles are completely dissolved, and standing for later use; s2, stably extruding the protein-like spinning solution in the step S1 by using a high-pressure liquid conveying pump, extruding the protein-like spinning solution into a coagulating bath through a multi-channel micro-fluidic chip or a porous spinneret plate, and carrying out wet spinning forming; s3, standing and drying the nascent fibers collected in the step S2 at normal temperature; s4, step-by-step differential stretching is conducted on the nascent fiber dried in the step S3 through a stretching roller, the stretching multiple is 3-10, heat treatment is conducted for 10-120 min at the temperature of 100-190 DEG C, and the high-performance protein-like fiber is obtained after shaping. According to the invention, spinning process amplification exploration on the protein-like fiber shows that the fiber has potential in the aspect of industrial preparation and has good application prospects in the fields of intelligent textiles and biomedical treatment.

Description

Technical Field

[0001] The invention relates to the field of fiber wet spinning technology, and more specifically to an enlarged preparation process of high-performance protein-like fibers. Background Art

[0002] Bionic materials refer to materials developed by imitating various characteristics or properties of organisms. People extract, explore and learn the structural laws of biological models and biological materials in nature, and design a series of bionic materials based on this principle. Bionic materials are highly designable, more environmentally friendly than plastic products, and have excellent product performance. Bionic fibers are an important component of bionic materials. Since the 20th century, people have developed various spinning methods for chemical fibers by simulating the process of silkworms spinning silk; people have discovered that a moth that is active at night has a micro-conical protrusion structure on the surface of its cornea, so by simulating this special structure, ultra-micro pit fibers are produced; as well as chemical fibers that are similar in morphology, structure, appearance and performance, or artificial fibers that imitate the contact between natural fibers and human skin. They are low-cost and highly efficient in production, and have become an indispensable part of people's daily lives.

[0003] The natural polymer fiber - spider silk has excellent elasticity and flexibility, strong impact resistance, and good low temperature resistance. Its strength is higher than that of aramid and ultra-high molecular weight polyethylene fibers. From the microstructure analysis of the material, natural spider silk has soft and hard segments, that is, a microphase separation structure formed by amorphous and crystalline regions. The crystalline phase is dispersed in the amorphous phase in the form of nanocrystals, and when the fiber is subjected to external tensile force, these microcrystals are axially oriented along the tensile direction, thereby giving the natural spider silk high strength. The non-crystalline region in the natural spider silk gives the spider silk high elasticity and flexibility. People have been inspired by the structure of natural spider silk and developed a new generation of high-strength and high-elasticity bionic fibers.

[0004] However, the current preparation processes of bionic fibers mainly include dry spinning, wet spinning and melt spinning. The wet spinning process can be applied to materials that cannot be melt-spun, such as natural biological macromolecules. However, the fiber breaking strength of the protein-like fibers prepared by the current wet spinning method is about 0.5-0.9 cN / dtex in dry state and about 0.35-0.88 cN / dtex in wet state, which has the defect of insufficient fiber strength. Summary of the invention

[0005] The purpose of the present invention is to provide a scaled-up preparation process for high-performance protein-like fibers, thereby solving the problem that the fiber strength of protein-like fibers prepared by the wet spinning process in the prior art is not high enough and the mechanical properties and flexibility are low.

[0006] In order to solve the above problems, the present invention adopts the following technical solutions:

[0007] According to a first aspect of the present invention, a scaled-up preparation process for high-performance protein-like fibers is provided, comprising the following steps: S1: dissolving protein-like particles in a solvent and stirring until completely dissolved, vacuum degassing and standing for use; wherein the solvent is one or more of DMF, DMA or DMSO; the prepared protein-like spinning solution has a concentration of 10wt%-30wt%; S2: using a high-pressure infusion pump to stably extrude the protein-like spinning solution in step S1, and squeeze it into a coagulation bath through a multi-channel microfluidic chip or a porous spinneret, and wet spinning to form; wherein the coagulation bath is pure water or an alcohol solution, and the alcohol solution includes: methanol, ethanol or isopropanol; S3: standing and drying the spun fibers collected in step S2 at room temperature; S4: using a stretching roller to perform step-by-step differential stretching on the spun fibers dried in step S3, with a stretching multiple of 3-10 times, and heat treating at a temperature of 100-190°C for 10-120min to obtain high-performance protein-like fibers.

[0008] Preferably, in step S1, the solvent is one or more of DMF, DMA or DMSO, and the most preferred solvent is DMSO.

[0009] Preferably, in step S1, the concentration of the protein-like spinning solution is 18wt%-25wt%.

[0010] Preferably, in step S2, the multi-channel microfluidic chip is a structural unit in which a central channel is connected to a liquid outlet tube of a high-pressure infusion pump, and a plurality of branch channels are evenly distributed in the same direction inside the chip, and the number of the branch channels is 6-200 channels.

[0011] Preferably, in step S2, the number of spinneret holes of the porous spinneret is 100-600 holes, the pore diameter is 50-150 μm, and the speed of the metering pump is 2-40 rpm.

[0012] Preferably, in step S2, the extrusion flow rate of the high-pressure infusion pump is 100-3000 μL / min.

[0013] Preferably, step S2 includes two coagulation baths, wherein the protein-like spinning solution is squeezed into the first coagulation bath through a multi-channel microfluidic chip or a porous spinneret, wet-spun into shape, and then continues to enter the second coagulation bath after passing through a first collecting roller.

[0014] Preferably, the first coagulation bath component is isopropanol, and the second coagulation bath component is anhydrous ethanol.

[0015] Also preferably, three isopropanol coagulation baths are used.

[0016] Preferably, in step S4, the rotation speed of the stretching roller is 1-100 rpm, the stretching ratio is 5-6 times; the heat setting temperature is 100-120° C., and the heat setting time is 30-40 min.

[0017] According to a preferred embodiment of the present invention, a high-performance protein-like fiber scale-up preparation process is provided, comprising the following steps:

[0018] 1) dissolving the protein-like particles in DMSO and stirring until completely dissolved to prepare a protein-like spinning solution with a concentration of 15 wt %, vacuum degassing and allowing to stand for use;

[0019] 2) using a high-pressure infusion pump to stably extrude the protein-like spinning solution in step S1, and the ten-channel microfluidic chip is squeezed into a first coagulation bath formed by isopropanol to form wet spinning; after passing through a first collecting roller, it continues to enter a second coagulation bath formed by anhydrous ethanol; wherein, the length of the first coagulation bath is 40 cm, the length of the second coagulation bath is 30 cm, the flow rate of the spinning solution is 170 μL / min, the rotation speed of the collecting roller is 5 rpm, and the diameter of the collecting roller is 75 mm;

[0020] 3) drying the spun fibers collected in step 2) at room temperature;

[0021] 4) The spun fibers dried in step 3) are subjected to step-by-step differential stretching by stretching rollers, wherein the rotation speed of the first stretching roller is 6 rpm and the rotation speed of the last stretching roller is 36 rpm, so that the final stretching multiple is 6 times, and the stretched fibers are placed in an oven at 120° C. for heat setting for 40 minutes, and high-performance protein-like fibers are obtained after heat treatment and setting.

[0022] According to this preferred embodiment, the prepared protein-like fibers have a fiber breaking strength of 74.84±2.63 cN, a fiber stress of 238.42±8.39 MPa, and a strain of 146.75±13.40%.

[0023] According to another preferred embodiment of the present invention, a high-performance protein-like fiber scale-up preparation process is provided, comprising the following steps:

[0024] 1) dissolving the protein-like particles in DMSO and stirring until completely dissolved to prepare a protein-like spinning solution with a concentration of 18 wt %, vacuum degassing and allowing to stand for use;

[0025] 2) using a wet spinning device to heat the protein-like spinning solution to 45° C. and then stably extrude it, and then squeeze it into a coagulation bath formed by isopropanol through a 50-hole spinneret, and wet-spin to form it; wherein the spinneret hole diameter is 200 μm, the coagulation bath length is 170 cm, the spinning solution flow rate is 170 μL / min, the rotation speed of the collecting roller is 5 rpm, and the diameter of the collecting roller is 75 mm;

[0026] 3) drying the spun fibers collected in step 2) at room temperature;

[0027] 4) The spun fibers dried in step 3) are subjected to step-by-step differential stretching by stretching rollers, wherein the rotation speed of the first stretching roller is 10 rpm and the rotation speed of the last stretching roller is 60 rpm, so that the final stretching multiple is 6 times, and the stretched fibers are placed in an oven at 120° C. for heat setting for 40 min, and high-performance protein-like fibers are obtained after heat treatment and setting.

[0028] According to this preferred embodiment, the prepared protein-like fibers have a fiber breaking strength of 64.81±2.40 cN, a fiber stress of 220.20±8.16 MPa, and a strain of 225.81±13.15%.

[0029] According to a second aspect of the present invention, there is provided a high-performance protein-like fiber prepared by the above-mentioned scaled-up preparation process.

[0030] Preferably, the high-performance protein-like fiber has a breaking strength of 100-500 MPa and an elongation at break of 70%-1000%.

[0031] At present, the main preparation processes include dry spinning, wet spinning and melt spinning. The wet spinning process can be applied to materials that cannot be melt-spun, such as natural biomacromolecules. However, the protein-like fibers prepared by the current wet spinning process have the defect that the fiber strength is not high enough. The fiber breaking strength is 0.5-0.9 cN / dtex in dry state and 0.35-0.88 cN / dtex in wet state. The protein-like fibers prepared by the present invention by optimizing the wet process parameters have higher mechanical properties and flexibility.

[0032] The key invention of the present invention is that by optimizing parameters such as protein-like spinning solution concentration, solvent type, spinning solution flow rate, coagulation bath composition, post-stretching multiple and heat treatment temperature, a high-performance protein-like fiber scale-up preparation process is developed, thereby preparing a protein-like fiber with improved fiber mechanical properties. In particular, this method has the potential for industrial scale-up production.

[0033] The present invention utilizes a wet spinning method to prepare a high-performance protein-like fiber. The wet spinning method mainly uses the diffusion of molecules to diffuse the solvent in the liquid stream ejected from the spinneret into the coagulation bath, thereby achieving the purpose of solidifying the fiber into shape. The wet spinning method has a simple process flow and low temperature. It can be compounded with biomacromolecules, nanoparticles such as metal particles, graphene and other materials to produce differential fibers, further broadening its application range. The protein-like fiber has good tensile properties, high mechanical strength, good elasticity, and has the characteristics of enhanced tensile mechanics. Through the exploration of the amplification of the spinning process of the protein-like fiber, it is shown that the fiber has potential in industrial preparation and has good application prospects in the fields of smart textiles and biomedicine.

[0034] The enlarged preparation process of a high-performance protein-like fiber provided by the present invention has the following beneficial effects compared with the prior art:

[0035] 1)1) Protein-like fibers have hard and soft segments, and the strength and elasticity of the fibers can be optimized by adjusting the spinning process to better match practical applications. Protein-like fiber materials have high tensile strength, toughness, biodegradability resistance and biocompatibility, and their performance is superior to fibers prepared by traditional melt spinning or wet spinning processes, and have good development prospects in the biomedical field.

[0036] 2) The raw materials for preparing protein-like fibers are cheap and readily available, and the exploration of scaled-up preparation processes has confirmed its potential for industrial production.

[0037] In summary, the present invention has developed a scaled-up preparation process for high-performance protein-like fibers, and thereby prepared a protein-like fiber with high strength and high elasticity, and expanded it through a spinning process, preliminarily verifying its feasibility of industrial production, which has important guiding significance for the scaled-up production process of some high-performance natural protein fibers. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] Figure 1 It is a top view schematic diagram of a device for preparing high-performance protein-like fibers according to the present invention;

[0039] Figure 2 This is a schematic diagram of the fiber post-stretching of the present invention;

[0040] Figure 3 is a stress / strain curve diagram of the fiber prepared in Example 1;

[0041] Figure 4 is a stress / strain curve diagram of the fiber prepared in Example 2;

[0042] Figure 5 is a stress / strain curve diagram of the fiber prepared in Example 3;

[0043] Figure 6 is a stress / strain curve diagram of the fiber prepared in Example 4;

[0044] Figure 7 is a stress / strain curve diagram of the fiber prepared in Example 5;

[0045] Figure 8 is a stress / strain curve diagram of the fiber prepared in Example 6;

[0046] Fig. 9 This is a physical picture of 20 strands of protein-like fibers;

[0047] The meanings of the reference numerals are as follows:

[0048] 1-high-pressure infusion pump; 2-protein spinning solution; 3-coagulation bath; 4-multi-channel microfluidic chip; 5-first collecting roller; 6-nascent fiber; 10-stretched fiber. DETAILED DESCRIPTION

[0049] The present invention will be further described below in conjunction with specific examples. It should be understood that the following examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. Unless otherwise specified, the reagents and materials used in the examples can be obtained from commercial sources unless otherwise specified.

[0050] Example 1

[0051] According to this embodiment, a high-performance protein fiber preparation is provided, combined with Figure 1 , Figure 2 The preparation method is described as follows:

[0052] 1) preparing a protein-like spinning solution, dissolving the protein-like particles (bionic spider silk material) in DMSO and stirring until completely dissolved, vacuum degassing and standing for use, the concentration of the protein-like spinning solution is 15% (wt);

[0053] 2) The protein-like spinning solution 2 is stably extruded by a high-pressure infusion pump 1, and is squeezed into an isopropanol coagulation bath 3 through a ten-channel microfluidic chip 4 to form wet spinning; wherein the coagulation bath has a length of 100 cm, a spinning solution flow rate of 170 μL / min, a collection roller 5 has a rotation speed of 5 rpm, and a roller diameter of 75 mm.

[0054] 3) drying the spun fibers 6 collected in 2) at room temperature;

[0055] 4) The spun fibers 6 dried in 3) are stretched in steps using stretching rollers, wherein the speed difference between the first stretching roller (rotation speed 6 rpm) and the last stretching roller (rotation speed 36 rpm) makes the final stretching multiple 6 times. The stretched fibers 10 are placed in an oven at 120° C. for heat setting for 40 minutes, and high-performance protein-like fibers are obtained after heat treatment and setting.

[0056] 5) Determine the mechanical properties of the fiber. The results are as follows: Figure 3 As shown, the fiber breaking strength is 67.29±3.77 cN, the stress is 226.78±12.70 MPa, and the strain is 137.86±48.55%.

[0057] Example 2

[0058] According to this embodiment, a high-performance protein-like fiber is prepared, and the preparation method is as follows:

[0059] 1) preparing a protein-like spinning solution, dissolving the protein-like particles in DMSO and stirring until completely dissolved, vacuum degassing and standing for use, the concentration of the protein-like spinning solution is 15% (wt);

[0060] 2) The protein-like spinning solution is stably extruded by a wet spinning device, and is squeezed into an isopropanol coagulation bath through a 200-hole spinneret to form wet spinning; wherein, an isopropanol coagulation bath is added between the first collecting roller and the second collecting roller, the isopropanol coagulation bath concentration is 100%, the spinneret aperture is 100 μm, the coagulation bath tank length is 70 cm, the spinning solution flow rate is 170 μL / min, and the speed ratio of the last collecting roller to the first collecting roller is 2.62 times.

[0061] 3) drying the spun fibers collected in 2) at room temperature;

[0062] 4) The spun fibers dried in 3) are stretched in steps using stretching rollers, wherein the speed difference between the first stretching roller (rotation speed 6 rpm) and the last stretching roller (rotation speed 36 rpm) makes the final stretching multiple 6 times. The stretched fibers are placed in an oven at 120°C for heat setting for 40 minutes, and high-performance protein-like fibers are obtained after heat treatment and setting.

[0063] 5) Determine the mechanical properties of the fiber. The results are as follows: Figure 4 As shown, the fiber breaking strength is 61.56±0.09 cN, the stress is 181.88±10.71 MPa, and the strain is 133.88±10.86%.

[0064] The main difference between Example 2 and Example 1 is that Example 1 uses ten-channel amplification, Example 2 uses 200-channel amplification, and two isopropyl alcohol coagulation baths are used, which indicates that after the fibers become thicker, the adhesion and entanglement between the fibers lead to similar overall performance.

[0065] Example 3

[0066] According to this embodiment, a high-performance protein-like fiber is prepared, and the preparation method is as follows:

[0067] 1) preparing a protein-like spinning solution, dissolving the protein-like particles in DMSO and stirring until completely dissolved, vacuum degassing and standing for use, the concentration of the protein-like spinning solution is 15% (wt);

[0068] 2) The protein-like spinning solution is stably extruded by a wet spinning device, and is squeezed into an isopropanol coagulation bath through a 500-hole spinneret to form a wet spinning solution; wherein the spinneret aperture is 60 μm, the coagulation bath length is 70 cm, the spinning solution flow rate is 170 μL / min, and the speed ratio of the last collecting roller to the first collecting roller is 2.16 times.

[0069] 3) drying the spun fibers collected in 2) at room temperature;

[0070] 4) The spun fibers dried in 3) are stretched in steps using stretching rollers, wherein the speed difference between the first stretching roller (rotation speed 6 rpm) and the last stretching roller (rotation speed 36 rpm) makes the final stretching multiple 6 times. The stretched fibers are placed in an oven at 120°C for heat setting for 40 minutes, and high-performance protein-like fibers are obtained after heat treatment and setting.

[0071] 5) Determine the mechanical properties of the fiber. The results are as follows: Figure 5 As shown, the fiber breaking strength is 0.95±0.18 cN, the fiber stress is 114.02±22.14 MPa, and the strain is 130.74±18.27%.

[0072] The difference between Example 3 and Example 2 is that the process is further enlarged to a 500-hole spinneret, which illustrates that after the fibers become thicker, the adhesion and entanglement between the fibers lead to similar overall performance.

[0073] Example 4

[0074] According to this embodiment, a high-performance protein-like fiber is prepared, and the preparation method is as follows:

[0075] 1) preparing a protein-like spinning solution, dissolving the protein-like particles in DMSO and stirring until completely dissolved, vacuum degassing and standing for use, the concentration of the protein-like spinning solution is 15% (wt);

[0076] The protein-like spinning solution is stably extruded by wet spinning equipment, squeezed into an isopropanol coagulation bath through a ten-channel microfluidic chip, and wet-spun into shape; after passing through a first collecting roller, it continues to enter a second coagulation bath, and the second coagulation bath composition is anhydrous ethanol; wherein, the length of the first isopropanol coagulation bath tank is 40 cm, the length of the second anhydrous ethanol coagulation bath tank is 30 cm, the spinning solution flow rate is 170 μL / min, the rotation speed of the collecting roller is 5 rpm, and the roller diameter is 75 mm.

[0077] 3) drying the spun fibers collected in 2) at room temperature;

[0078] 4) The spun fibers dried in 3) are stretched in steps using stretching rollers, wherein the speed difference between the first stretching roller (rotation speed 6 rpm) and the last stretching roller (rotation speed 36 rpm) makes the final stretching multiple 6 times. The stretched fibers are placed in an oven at 120°C for heat setting for 40 minutes, and high-performance protein-like fibers are obtained after heat treatment and setting.

[0079] 5) Determine the mechanical properties of the fiber. The results are as follows: Figure 6 As shown, the fiber breaking strength is 74.84±2.63 cN, the fiber stress is 238.42±8.39 MPa, and the strain is 146.75±13.40%.

[0080] The main difference between Example 4 and Example 1 is that an anhydrous ethanol coagulation bath is added, which shows that adding an anhydrous ethanol coagulation bath can reduce the adhesion and disturbance between fibers, guide the orderly assembly of protein-like molecules, and improve the mechanical properties.

[0081] Example 5

[0082] According to this embodiment, a high-performance protein-like fiber is prepared, and the preparation method is as follows:

[0083] 1) preparing a protein-like spinning solution, dissolving the protein-like particles in DMSO and stirring until completely dissolved, vacuum degassing and standing for use, the concentration of the protein-like spinning solution is 18% (wt);

[0084] 2) The protein-like spinning solution is heated to 45° C. by a wet spinning device, and then stably extruded, and then squeezed into an isopropanol coagulation bath through a 50-hole spinneret, and wet-spun into shape; wherein the spinneret hole diameter is 200 μm, the coagulation bath length is 170 cm, the spinning solution flow rate is 170 μL / min, the rotation speed of the collecting roller is 5 rpm, and the roller diameter is 75 mm.

[0085] 3) drying the spun fibers collected in 2) at room temperature;

[0086] 4) The spun fibers dried in 3) are stretched in steps using stretching rollers, wherein the speed difference between the first stretching roller (rotation speed 10 rpm) and the last stretching roller (rotation speed 60 rpm) makes the final stretching multiple 6 times. The stretched fibers are placed in an oven at 120°C for heat setting for 40 minutes, and high-performance protein-like fibers are obtained after heat treatment and setting.

[0087] 5) Determine the mechanical properties of the fiber. The results are as follows: Figure 7 As shown, the fiber breaking strength is 64.81±2.40 cN, the fiber stress is 220.20±8.16 MPa, and the strain is 225.81±13.15%.

[0088] The difference between Example 5 and Example 2 is that the concentration of the protein-like solution is increased, the stretching multiple is increased, and the fiber breaking strength of the fiber prepared thereby is greatly improved.

[0089] Example 6

[0090] According to this embodiment, a high-performance protein-like fiber is prepared, and the preparation method is as follows:

[0091] 1) preparing a protein-like spinning solution, dissolving the protein-like particles in DMSO and stirring until completely dissolved, and performing vacuum degassing in a reactor of a wet spinning equipment, wherein the concentration of the protein-like spinning solution is 25% (wt);

[0092] 2) The protein-like spinning solution is heated to 45°C by wet spinning equipment and then stably extruded, and then squeezed into the first coagulation bath of isopropanol through a 127-hole spinneret, and wet-spun into shape; after passing through the first collecting roller, it continues to enter the second coagulation bath, and then passes through the second collecting roller and enters the third coagulation bath, and the components of these three coagulation baths are all isopropanol; wherein, the length of the first coagulation bath tank is 90cm, the length of the second coagulation bath tank is 500cm, and the length of the third coagulation bath tank is 130cm. Among them, the spinneret hole diameter is 200μm, the spinning solution flow rate is 750μL / min, the rotation speed of the collecting roller is 45rpm, and the roller diameter is 75mm.

[0093] 3) drying the spun fibers collected in 2) at room temperature;

[0094] 4) The spun fibers dried in 3) are stretched in steps using stretching rollers, wherein the speed difference between the first stretching roller (rotation speed 10 rpm) and the last stretching roller (rotation speed 50 rpm) makes the final stretching multiple 5 times, and the stretched fibers are placed in an oven at 120°C for heat setting for 40 minutes, and high-performance protein-like fibers are obtained after heat treatment and setting.

[0095] 5) Determine the mechanical properties of the fiber. The results are as follows: Figure 8 As shown, the fiber breaking strength is 55.81±3.05 cN, the fiber stress is 202.74±11.07 MPa, and the strain is 175.88±11.85%.

[0096] The difference between Example 6 and Example 2 is that the concentration of the protein-like solution is increased, the stretching multiple is increased, and two isopropanol coagulation baths are added, so that the fiber breaking strength of the fiber prepared thereby is also greatly improved.

[0097] The above is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention. The above embodiments of the present invention can also be modified in various ways. All simple, equivalent changes and modifications made according to the claims and the description of the present invention fall within the scope of protection of the claims of the present invention. The contents not described in detail in the present invention are all conventional technical contents.

Claims

1. A high-performance protein fiber scale-up preparation process, characterized in that: The following steps are involved: S1: dissolving the protein-like particles in a solvent and stirring until completely dissolved, vacuum degassing and standing for use; wherein the solvent is one or more of DMF, DMA or DMSO; and the concentration of the prepared protein-like spinning solution is 10wt%-30wt%; S2: using a high-pressure infusion pump to stably extrude the protein-like spinning solution in step S1, and squeeze it into a coagulation bath through a multi-channel microfluidic chip or a porous spinneret, and wet-spinning to form the solution; wherein the coagulation bath is pure water or an alcohol solution, and the alcohol solution includes: methanol, ethanol or isopropanol; S3: drying the spun fibers collected in step S2 at room temperature; S4: using stretching rollers to perform step-by-step differential stretching on the spun fibers dried in step S3, with a stretching multiple of 3-10 times, and heat treating at a temperature of 100-190° C. for 10-120 min to obtain high-performance protein-like fibers.

2. The enlarged preparation process according to claim 1, characterized in that: In step S2, the multi-channel microfluidic chip is a structural unit in which a central channel is connected to the outlet tube of a high-pressure infusion pump, and a plurality of branch channels are evenly distributed in the same direction inside the chip, and the number of the branch channels is 6-200 channels.

3. The enlarged preparation process according to claim 1, characterized in that: In step S2, the number of spinneret holes of the porous spinneret is 100-600 holes, the pore diameter is 50-150 μm, and the speed of the metering pump is 2-40 rpm.

4. The enlarged preparation process according to claim 1, characterized in that: In step S2, the extrusion flow rate of the high-pressure infusion pump is 100-3000 μL / min.

5. The enlarged preparation process according to claim 1, characterized in that: Step S2 includes two coagulation baths, wherein the protein-like spinning solution is squeezed into the first coagulation bath through a multi-channel microfluidic chip or a porous spinneret, wet-spun into shape, and then passes through a first collecting roller and continues to enter the second coagulation bath.

6. The enlarged preparation process according to claim 5, characterized in that: The first coagulation bath component is isopropyl alcohol, and the second coagulation bath component is anhydrous ethanol.

7. The enlarged preparation process according to claim 1, characterized in that: In step S4, the rotation speed of the stretching roller is 1-100 rpm, the stretching ratio is 5-6 times; the heat setting temperature is 100-120° C., and the heat setting time is 30-40 min.

8. The enlarged preparation process according to claim 1, characterized in that: The following steps are involved: 1) dissolving the protein-like particles in DMSO and stirring until completely dissolved to prepare a protein-like spinning solution with a concentration of 15 wt %, vacuum degassing and allowing to stand for use; 2) using a high-pressure infusion pump to stably extrude the protein-like spinning solution in step S1, and the ten-channel microfluidic chip is squeezed into a first coagulation bath formed by isopropanol to form wet spinning; after passing through a first collecting roller, it continues to enter a second coagulation bath formed by anhydrous ethanol; wherein, the length of the first coagulation bath is 40 cm, the length of the second coagulation bath is 30 cm, the flow rate of the spinning solution is 170 μL / min, the rotation speed of the collecting roller is 5 rpm, and the diameter of the collecting roller is 75 mm; 3) drying the spun fibers collected in step 2) at room temperature; 4) The spun fibers dried in step 3) are subjected to step-by-step differential stretching by stretching rollers, wherein the rotation speed of the first stretching roller is 6 rpm and the rotation speed of the last stretching roller is 36 rpm, so that the final stretching multiple is 6 times, and the stretched fibers are placed in an oven at 120° C. for heat setting for 40 minutes, and high-performance protein-like fibers are obtained after heat treatment and setting.

9. The enlarged preparation process according to claim 1, characterized in that: The following steps are involved: 1) dissolving the protein-like particles in DMSO and stirring until completely dissolved to prepare a protein-like spinning solution with a concentration of 18 wt %, vacuum degassing and allowing to stand for use; 2) using a wet spinning device to heat the protein-like spinning solution to 45° C. and then stably extrude it, and then squeeze it into a coagulation bath formed by isopropanol through a 50-hole spinneret, and wet-spin to form it; wherein the spinneret hole diameter is 200 μm, the coagulation bath length is 170 cm, the spinning solution flow rate is 170 μL / min, the rotation speed of the collecting roller is 5 rpm, and the diameter of the collecting roller is 75 mm; 3) drying the spun fibers collected in step 2) at room temperature; 4) The spun fibers dried in step 3) are subjected to step-by-step differential stretching by stretching rollers, wherein the rotation speed of the first stretching roller is 10 rpm and the rotation speed of the last stretching roller is 60 rpm, so that the final stretching multiple is 6 times, and the stretched fibers are placed in an oven at 120° C. for heat setting for 40 min, and high-performance protein-like fibers are obtained after heat treatment and setting.

10. A high-performance protein-like fiber prepared by the scaled-up preparation process according to any one of claims 1 to 9.

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