Thiazole ring-containing phenyl amide bactericide and application thereof

Abstract

The invention relates to the technical field of bactericides, and discloses a thiazole ring-containing phenylamide bactericide and application thereof, the specific ingredients comprise 20% of an active component, 5% of a biodegradation accelerator, 10% of a natural antibacterial component, 3% of a biodegradable surfactant, 2% of a thickener and 60% of a filler. According to the thiazole ring phenyl amide-containing bactericide and the application thereof, the active components and the auxiliary components in the formula are all selected from easily degradable materials, and especially the biodegradation accelerant is added, so that the degradation of the active components in the natural environment can be accelerated, and the adverse effects on soil, water sources and non-target organisms are reduced; and the glycoside surfactant is selected, the surfactant is easy to degrade in the environment, the potential harm of chemical residues to an ecological system is reduced, and the thickening agent with good stability and biocompatibility and the filling agent with good adsorption performance are adopted, so that the selectivity and the stability of the formula are favorably improved.

Description

Technical Field

[0001] The invention relates to the technical field of fungicides, in particular to a thiazole ring-containing phenylamide fungicide and application thereof. Background Art

[0002] Fungicides are chemical or biological agents used to prevent and control plant diseases. They are mainly used to eliminate or inhibit the growth and development of plant pathogens (such as fungi, bacteria, viruses, etc.). Fungicides are one of the commonly used plant protection products in agricultural and horticultural practices. They are widely used on various crops and plants to protect crops from diseases, thereby increasing crop yield and quality. However, traditional fungicides contain chemical components that are not easily degradable. Long-term use may lead to soil and water pollution. Moreover, traditional fungicides can only be used for the prevention and control of a single crop or a specific type of disease, causing chemical components to enter the water body with runoff, affecting water quality and threatening aquatic ecosystems. In addition, long-term use of a single type of fungicide will cause pathogens to develop drug resistance, resulting in a decrease in the effectiveness of the fungicide, which in turn requires increasing the dosage or replacing it with a new fungicide, forming a vicious circle. Summary of the invention

[0003] The purpose of this section is to summarize some aspects of embodiments of the present invention and briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section and the specification abstract and the invention title of this application to avoid blurring the purpose of this section, the specification abstract and the invention title, and such simplifications or omissions cannot be used to limit the scope of the present invention.

[0004] To achieve the above object, the present invention provides the following technical solutions: A thiazole ring phenylamide-containing fungicide and its application, the specific ingredients of which include: Active ingredient (novel thiazole cyclophenylamide) 20%, biodegradation promoter (natural enzyme) 5%, natural antibacterial ingredient (plant extract) 10%, biodegradable surfactant 3%, thickener (natural gum) 2% and filler (natural mineral) 60%; The active ingredient (novel thiazole ring phenylamide) comprises a thiazole ring, a phenylamide and a substituent; The novel thiazole cyclophenylamide inhibits the growth of pathogens or directly kills the pathogens by interfering with the cell wall synthesis, cell membrane function, protein synthesis or metabolic pathway of the pathogens.

[0005] As a further solution of the present invention: the biodegradation accelerator is a specific natural enzyme and enzyme preparation that can accelerate the degradation of active ingredients in the natural environment, and the enzyme preparation is preferably selected from proteases and lipases in bacteria and fungi.

[0006] As a further solution of the present invention: the natural antibacterial ingredients include thyme essential oil and tea tree oil, and the plant extracts are preferably selected from plants with broad-spectrum antibacterial activity.

[0007] As a further embodiment of the present invention: the biodegradable surfactant is a glycoside degradable surfactant, preferably a surfactant derived from glucoside and sucrose ester.

[0008] As a further solution of the present invention: the thickener is xanthan gum and sodium alginate natural colloid materials, and the thickener is preferably selected from colloids with good stability and biocompatibility; the filler is diatomaceous earth mineral, and the filler is preferably selected from mineral materials with good adsorption properties and environmental friendliness.

[0009] As a further solution of the present invention: the fungicide further comprises one or more of a stabilizer, a safener, and a wetting enhancer, the total mass percentage of the auxiliary agent is 0.2%-1.5%, and the auxiliary agent is preferably selected from biodegradable materials.

[0010] As a further solution of the present invention: an antioxidant is added to the fungicide during the preparation process to prevent oxidative degradation of the active ingredient during storage, and the added amount of the antioxidant does not exceed 1% of the total mass. The fungicide adopts microencapsulation technology during the preparation process to encapsulate the active ingredient in a biodegradable polymer to improve its stability and controlled release effect.

[0011] The invention discloses an application of a thiazole cyclophenylamide-containing fungicide, which is used for preventing and controlling diseases in crop fields. The application period is the early growth period of the crops, the dosage is 50-100 ml / mu, the water consumption is 45-60 kg / mu, and the application method is soil spraying.

[0012] As a further solution of the present invention: the fungicide is suitable for preventing and controlling annual weeds in rice fields, including barnyard grass, lycopodiella cuneata and crabgrass, and the application period is 2-4 days after rice germination and sowing.

[0013] As a further solution of the present invention: the fungicide is also used for post-harvest treatment of fruits and vegetables to extend the shelf life and reduce rot losses, with a usage concentration of 0.05%-0.2%. The fungicide needs to be fully stirred before application to ensure uniform distribution of the components, and maintain a certain humidity after application to facilitate the absorption of active ingredients.

[0014] Compared with the prior art, the present invention has the following beneficial effects: 1. The active ingredients and auxiliary ingredients in the formula are all made of easily degradable materials. In particular, the addition of biodegradation accelerators can accelerate the degradation of active ingredients in the natural environment, reducing the adverse effects on soil, water sources and non-target organisms. Glycoside surfactants are selected, which are easy to degrade in the environment, reducing the potential harm of chemical residues to the ecosystem. Thickeners with good stability and biocompatibility and fillers with good adsorption properties are used to help improve the selectivity and stability of the formula; 2. By controlling the amount of additives added between 0.2% and 1.5% and selecting biodegradable materials, it helps to improve the safety and effectiveness of the formula. By using microencapsulation technology to encapsulate the active ingredients in biodegradable polymers, the stability and controlled-release effect of the fungicide are improved, thereby enhancing its durability and effectiveness in practical applications. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a comparison chart of the usage technology of a thiazole ring phenylamide fungicide and its application. DETAILED DESCRIPTION

[0016] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and understandable, the specific implementation modes of the present invention are described in detail below in conjunction with the accompanying drawings.

[0017] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein, and those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0018] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The term "in one embodiment" that appears in different places in this specification does not necessarily refer to the same embodiment, nor does it refer to a separate or selective embodiment that is mutually exclusive with other embodiments.

[0019] Example 1 See also Figure 1 , which is the first embodiment of the present invention, provides a thiazole ring phenylamide-containing fungicide and its application, the fungicide is a common fungicide formula, specifically as follows: Laboratory preparation steps: Raw materials preparation: Active ingredient (novel thiazole cyclophenylamide) 200 g; Biodegradation accelerator (natural enzyme) 50g; Natural antibacterial ingredient (thyme essential oil) 100g; Biodegradable surfactant (glucoside) 30 g; Thickener (xanthan gum) 20g; Filler (diatomaceous earth) 600 g; Some water (distilled water); mix: In a clean container, add the filler (diatomaceous earth) first, then the thickener (xanthan gum), natural antibacterial ingredient (thyme essential oil), biodegradable surfactant (glucosidase) and biodegradation promoter (natural enzyme) in sequence, stirring gently after each addition to ensure even mixing; Active ingredient added: The active ingredient (novel thiazole cyclophenylamide) is added to the mixture last and stirring is continued until it is completely evenly distributed; Dissolution and dispersion: Slowly add distilled water to the mixture and keep stirring using an electric stirrer until all ingredients are completely dissolved and evenly dispersed in the water; Adjust pH: Use pH paper to test the pH of the solution. If the pH is not within the ideal range (6-7), add a small amount of acid or base (citric acid or sodium hydroxide) to adjust the pH. filter: Strain the mixture through filter paper or a strainer to remove any undissolved particles; Filling and sealing: Pour the prepared disinfectant solution into a pre-cleaned and sterilized plastic bottle, seal it and label it; Field application steps Prepare: Clean the spray equipment and make sure there is no other pesticide residue; Prepare the required 450 liters of clean water; dilution: Weigh 50 ml of fungicide solution and add it to 450 liters of clean water, stirring evenly; spray: In rice fields, spraying should be carried out 2-4 days after rice germination and sowing, ensuring that the nozzles are evenly distributed over the field and the spraying speed is kept consistent so that the soil surface is evenly covered; Observation and Recording: Record spraying date, weather conditions and spraying area information; Regularly check the growth of weeds such as barnyard grass in rice fields and record changes in their numbers.

[0020] The experimental data table is as follows:

[0021] Example 2 See also Figure 1 , which is the second embodiment of the present invention, provides a thiazole ring phenylamide-containing fungicide and its application, the fungicide is a new fungicide ingredient, specifically as follows: Raw materials preparation: Active ingredient (novel thiazole cyclophenylamide) 200 g; Biodegradation accelerator (natural enzyme) 50g; Natural antibacterial ingredient (thyme essential oil) 100g; Biodegradable surfactant (glucoside) 30 g; Thickener (xanthan gum) 20g; Filler (diatomaceous earth) 600 g; Stabilizer (biodegradable material) 5 grams; Wetting enhancer (biodegradable material) 5g; Antioxidants (no more than 1 gram); Several microencapsulated polymer materials (PLGA); Some water (distilled water); Microcapsule preparation: The active ingredient was mixed with the microencapsulation polymer material and formed into microcapsules using a spray drying method; the specific parameters were as follows: feed temperature 50°C, outlet temperature 30°C, air flow rate 600L / min; mix: Mix the remaining ingredients in the order described in Example 1, stirring gently after each addition; Dissolution and dispersion: Add distilled water to the mixture and stir using an electric stirrer until completely dissolved and evenly dispersed; Adjust pH: Use pH test paper to check the pH value of the solution and adjust it to the ideal range if necessary; Filtration and filling: After filtering the mixed liquid, fill it into a plastic bottle and seal it; Field application steps: Prepare: Same as Example 1; dilution: Weigh 100 ml of the fungicide solution and add it to 600 liters of clean water and stir evenly; spray: For rice fields, spraying should also be done 2-4 days after rice germination and sowing, and spray evenly; Fruit and vegetable processing: For fruits and vegetables, use a 0.1% fungicide solution, that is, add 100 ml of fungicide to every 100 liters of water and spray on the surface of fruits and vegetables; Observation and Recording: Record spraying dates and weather conditions, and regularly check rice fields for weeds and the shelf life of fruits and vegetables.

[0022] The experimental data table is as follows:

[0023] Detailed data description: Example 1

[0024] Initial state (2024-08-10): Weed density: 10 weeds per square meter; Weed species: mainly barnyard grass, Leptochloa chinensis and crabgrass; 10 days later (2024-08-20): Weed density: weeds are reduced to 2 per square meter; Weed species: The number of major weeds has been significantly reduced; 20 days later (2024-9-01): Weed density: weeds are reduced to 1 per square meter; Weed species: Most weeds are suppressed and field diseases are well controlled; Example 2

[0025] Initial state (2024-08-10): Weed density: 10 weeds per square meter; Weed species: mainly barnyard grass, Leptochloa chinensis and crabgrass; Shelf life of fruits and vegetables: The shelf life of untreated fruits and vegetables is about 7 days; 10 days later (2024-08-20): Weed density: weeds are reduced to 2 per square meter; Weed species: The number of major weeds has been significantly reduced; Shelf life of fruits and vegetables: The shelf life of treated fruits and vegetables is extended to 14 days; 20 days later (2024-9-01): Weed density: weeds are reduced to 1 per square meter; Weed species: Most weeds are suppressed and field diseases are well controlled; Shelf life of fruits and vegetables: The shelf life of treated fruits and vegetables is extended to 21 days; By comparing the data of Example 1 and Example 2, it can be seen that Example 2 not only shows a higher efficiency in preventing and controlling rice field diseases (the prevention and control effect reaches 92%), but also significantly extends the shelf life of fruits and vegetables by adopting the innovative method of microcapsule technology and antioxidants.

[0026] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the claims of the present invention.

Claims

1. A thiazole ring phenylamide-containing fungicide, characterized in that: Its specific ingredients include: Active ingredients 20%, biodegradation promoter 5%, natural antibacterial ingredients 10%, biodegradable surfactant 3%, thickener 2% and filler 60%.

2. A thiazole ring phenylamide fungicide according to claim 1, characterized in that: The biodegradation accelerator is a natural enzyme and an enzyme preparation, and the enzyme preparation is selected from proteases and lipases in bacteria and fungi.

3. A thiazole ring phenylamide fungicide according to claim 1, characterized in that: The natural antibacterial component comprises thyme essential oil and tea tree oil, and the plant extract is selected from plants with antibacterial activity.

4. A thiazole ring phenylamide fungicide according to claim 1, characterized in that: The biodegradable surfactant is a glycoside surfactant selected from glucoside and sucrose ester.

5. A thiazole ring phenylamide fungicide according to claim 1, characterized in that: The thickener is xanthan gum and sodium alginate natural colloid materials, and the filler is diatomaceous earth mineral selected from mineral materials.

6. A thiazole ring phenylamide-containing fungicide according to claim 1, characterized in that: The bactericide further comprises a stabilizer, a safener and a wetting enhancer, the total mass percentage of the auxiliary agent is 0.2%-1.5%, and the auxiliary agent is preferably selected from biodegradable materials.

7. A thiazole ring phenylamide-containing fungicide according to claim 1, characterized in that: An antioxidant is added to the fungicide during the preparation process to prevent the active ingredient from oxidative degradation during storage. The added amount of the antioxidant does not exceed 1% of the total mass. The fungicide adopts microencapsulation technology during the preparation process to encapsulate the active ingredient in a biodegradable polymer to improve its stability and controlled release effect.

8. A use of a thiazole ring phenylamide-containing fungicide, comprising a thiazole ring phenylamide-containing fungicide according to any one of claims 1 to 7, characterized in that: The fungicide is used for preventing and controlling diseases in crop fields. The application period is the early growth period of crops. The dosage is 50-100 ml / mu, the water dosage is 45-60 kg / mu, and the application method is soil spraying.

9. The use of a thiazole ring phenylamide fungicide according to claim 8, characterized in that: The fungicide is suitable for preventing and controlling annual weeds in rice fields, including barnyard grass, lycopodiella ciliata and crabgrass, and the application period is 2-4 days after rice germination and sowing.

10. The use of a thiazole ring phenylamide fungicide according to claim 8, characterized in that: The fungicide is used for post-harvest treatment of fruits and vegetables, and the use concentration is 0.05%-0.2%. The fungicide needs to be fully stirred before application and maintain humidity after application.

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