Inactivated bacterium composition based on ultrahigh-temperature instantaneous sterilization processing technology

Abstract

The invention relates to the technical field of health-care products, and particularly discloses an inactivated bacterium composition based on an ultrahigh-temperature instantaneous sterilization processing technology. The inactivated bacterium composition based on the ultrahigh-temperature instantaneous sterilization processing technology comprises the following components in parts by mass: 0.9-1.1 parts of milk powder; 0.8 to 1 part of L-glutamine; 0.3 to 0.5 part of protein powder; 0.009 to 0.011 part of inactivated lactobacillus reuteri; 0.14 to 0.16 part of a pH (Potential of Hydrogen) regulator; 1.46 to 1.62 parts of composite plant powder; 1.5 to 1.62 parts of a composite plant extract; the composite plant powder is formed by compounding konjaku flour, lotus root starch, Chinese yam powder and hericium erinaceus powder; the composite plant extract is prepared by compounding a radix glehniae extract, a bulbophyllum indicum fruit extract and a hypnea haplocalyx extract. The helicobacter pylori removing device has the advantage that helicobacter pylori in the body can be thoroughly removed.

Description

Technical Field

[0001] The invention relates to the field of health care products, in particular to an inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology. Background Art

[0002] In recent years, as people's health awareness has increased, they have paid more and more attention to the prevention and treatment of digestive system diseases, especially gastric diseases. Helicobacter pylori (H.pylori) infection is considered to be one of the main causes of gastritis and gastric ulcers. The common treatment method on the market is mainly to eradicate Helicobacter pylori through combined antibiotic therapy, but this method is prone to drug resistance and has certain side effects on the human body when used for a long time.

[0003] Treating Helicobacter pylori with inactivated bacteria based on ultra-high temperature instantaneous sterilization processing technology is a new direction at present. Inactivated Lactobacillus reuteri can expel Helicobacter pylori from the body through adsorption. This treatment method can reduce Helicobacter pylori to a certain extent, but its adsorption effect is proportional to the number of Helicobacter pylori in the body. When the number of Helicobacter pylori in the body decreases, the remaining Helicobacter pylori rapidly becomes firmer in the gastric mucosal tissue. It is difficult to adsorb Helicobacter pylori with higher parasitic fastness through inactivated Lactobacillus reuteri, resulting in a significant decrease in the effect of adsorbing Helicobacter pylori. As a result, the inactivated Lactobacillus reuteri can only be taken continuously to control the number of Helicobacter pylori within a certain range, reducing the serious damage to the human body caused by the massive reproduction of Helicobacter pylori, but it is difficult to cure it. Therefore, there is still room for improvement. Summary of the invention

[0004] In order to more thoroughly eliminate Helicobacter pylori in the body, the present application provides an inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology.

[0005] The present application provides a sterilization composition based on ultra-high temperature instantaneous sterilization processing technology, which adopts the following technical solution: A sterilization composition based on ultra-high temperature instantaneous sterilization processing technology, comprising the following components in parts by weight: 0.9-1.1 parts of milk powder; L-glutamine 0.8-1 part; 0.3-0.5 portions of protein powder; 0.009-0.011 parts of inactivated Lactobacillus reuteri; pH regulator 0.14-0.16 parts; 1.46-1.62 parts of compound plant powder; 1.5-1.62 parts of compound plant extract; The composite plant powder is a compound of konjac powder, lotus root powder, yam powder and hericium erinaceus powder; The composite plant extract is a compound of Glehnia littoralis extract, Psoralea corylifolia extract and Psoralea corylifolia extract.

[0006] By adopting the above technical scheme, when the number of Helicobacter pylori is large, the inactivated Lactobacillus reuteri can be used to excrete the Helicobacter pylori out of the body through high adsorption capacity, and then the composite plant extract composed of Adenophora australis extract, Psoralea corylifolia extract and Gnaphalium wilfordii extract can be used to promote Helicobacter pylori to leave the gastric mucosal tissue, so that the Helicobacter pylori with a higher degree of parasitism can actively leave the gastric mucosal tissue, thereby being better adsorbed by the inactivated Lactobacillus reuteri and excreted from the body, so that the Helicobacter pylori in the body can be eliminated more thoroughly.

[0007] By adding a compound plant powder made of konjac powder, lotus root powder, yam powder and Hericium erinaceus powder, it can have a better effect on regulating the stomach and intestines, allowing the stomach and intestines to recover health faster.

[0008] Preferably, the mass ratio of the Glehnia littoralis extract, the Psoralea corylifolia extract and the Psoralea corylifolia extract is 0.55-0.59:0.23-0.27:0.72-0.76.

[0009] By adopting the above technical scheme and specifically selecting the mass ratio of Glehnia littoralis extract, Psoralea corylifolia extract and Glehnia littoralis extract, the effect of promoting Helicobacter pylori to leave the gastric mucosal tissue can be better, Helicobacter pylori can be better eliminated, and Helicobacter pylori infection can be eliminated more quickly.

[0010] Preferably, the mass ratio of the konjac flour, lotus root flour, yam flour and hericium erinaceus flour is 0.38-0.42:0.38-0.42:0.35-0.39:0.35-0.39.

[0011] By adopting the above technical scheme and specifically selecting the mass ratio of konjac flour, lotus root flour, yam flour and hericium erinaceus flour, the effect of regulating the stomach and intestines is better and more beneficial to human health.

[0012] Preferably, the Glehnia littoralis extract, Psoralea corylifolia extract and Glehnia littoralis extract are all water-soluble extracts.

[0013] By adopting the above technical scheme, since the Northern Glehnia littoralis extract, the Psoralea corylifolia extract and the Glehnia littoralis extract are all water-soluble extracts, the composite plant extract can be better absorbed by the gastrointestinal tract, thereby better promoting the parasitic Helicobacter pylori to leave the human tissue, so as to be better adsorbed by the inactivated Lactobacillus reuteri and excreted from the body.

[0014] Preferably, the pH adjuster is sodium bicarbonate.

[0015] By adopting the above technical solution and specifically selecting sodium bicarbonate, the gastrointestinal pH value can be better regulated, and the gastrointestinal conditioning effect can be better.

[0016] Preferably, the milk powder is whole milk powder.

[0017] By adopting the above technical solution and specifically selecting whole milk powder, it is more beneficial to the human body, is beneficial to human health, and accelerates gastrointestinal recovery.

[0018] Preferably, the protein powder is soy protein powder.

[0019] By adopting the above technical solution and specifically selecting soy protein powder, the effect of regulating the stomach and intestines is better, and the stomach and intestines can recover health more quickly.

[0020] Preferably, the preparation method of the inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology is as follows: Milk powder, L-glutamine, protein powder, inactivated Lactobacillus reuteri, pH regulator, composite plant powder and composite plant extract are weighed and mixed evenly to obtain an inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology.

[0021] By adopting the above technical scheme, the inactivated bacteria composition prepared based on ultra-high temperature instantaneous sterilization processing technology can more thoroughly eliminate Helicobacter pylori in the body, restore the gastrointestinal health and is less likely to relapse.

[0022] In summary, this application has the following beneficial effects: 1. Since the present application can inactivate Lactobacillus reuteri when the number of Helicobacter pylori is large, it can remove Helicobacter pylori from the body through excretion through high adsorption capacity, and then through the action of the composite plant extract composed of Northern Glehnia extract, Psoralea corylifolia extract, and Glehnia littoralis extract, it can promote Helicobacter pylori to leave the gastric mucosal tissue, so that the Helicobacter pylori with a higher degree of parasitism will actively leave the gastric mucosal tissue, so that it can be better adsorbed by the inactivated Lactobacillus reuteri and excreted from the body, so that the Helicobacter pylori in the body can be eliminated more thoroughly.

[0023] 2. In the present application, it is preferred to specifically select the mass ratio of Glehnia littoralis extract, Psoralea corylifolia extract and Glehnia littoralis extract to better promote Helicobacter pylori to leave the gastric mucosal tissue, better eliminate Helicobacter pylori, and more quickly eliminate Helicobacter pylori infection.

[0024] 3. In the present application, it is preferred to specifically select the mass ratio of konjac flour, lotus root flour, yam flour and hericium erinaceus powder, which has a better effect on regulating the stomach and intestines and is more beneficial to human health. DETAILED DESCRIPTION

[0025] The present application is further described in detail below with reference to the embodiments.

[0026] Example 1 An inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology comprises the following components: Milk powder, L-glutamine, protein powder, inactivated Lactobacillus reuteri, pH adjuster, compound plant powder, compound plant extract.

[0027] The milk powder is whole milk powder purchased from Fonterra Cooperative Group Limited.

[0028] L-Glutamine was purchased from Hebei Huayang Biotechnology Co., Ltd.

[0029] The protein powder was soy protein powder purchased from Shandong Yuxin Biotechnology Co., Ltd.

[0030] The inactivated Lactobacillus reuteri was purchased from Qingdao Miaopinyuan International Trade Co., Ltd.

[0031] The pH adjuster was sodium bicarbonate purchased from Tongbai Boyuan New Chemical Co., Ltd.

[0032] The composite plant powder is a compound of konjac powder, lotus root powder, yam powder and hericium erinaceus powder.

[0033] Konjac flour was purchased from Zhejiang Shangfang Biotechnology Co., Ltd.

[0034] The lotus root powder was purchased from Xinghua Lvshuai Food Co., Ltd.

[0035] The yam powder was purchased from Xi'an Tianyi Biotechnology Co., Ltd.

[0036] Hericium erinaceus powder was purchased from Xi'an Tianyi Biotechnology Co., Ltd.

[0037] The composite plant extract is a combination of Glehnia littoralis extract, Psoralea corylifolia extract and Glehnia littoralis extract.

[0038] The extract of Adenophora dahurica was purchased from Xi'an Ruierli Bioengineering Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0039] The paulownia scoparia extract was purchased from Shaanxi Bocuijian Biotechnology Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0040] The extract of Glehnia littoralis was purchased from Baoji Cosmeco Cosmetics Raw Material Development Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0041] The preparation method of the inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology is as follows: Weigh 0.9kg of whole milk powder, 0.8kg of L-glutamine, 0.3kg of soy protein powder, 0.009kg of inactivated Lactobacillus reuteri, 0.14kg of sodium bicarbonate, 0.38kg of konjac flour, 0.38kg of lotus root powder, 0.35kg of yam powder, 0.35kg of Hericium erinaceus powder, 0.55kg of Adenophora adenophora extract, 0.23kg of Psoralea corylifolia extract, and 0.72kg of Glehnia littoralis extract, put them into a stirring kettle, rotate at 240r / min, stir for 30min, and mix evenly to obtain an inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology.

[0042] Example 2 An inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology comprises the following components: Milk powder, L-glutamine, protein powder, inactivated Lactobacillus reuteri, pH adjuster, compound plant powder, compound plant extract.

[0043] The milk powder is whole milk powder purchased from Fonterra Cooperative Group Limited.

[0044] L-Glutamine was purchased from Hebei Huayang Biotechnology Co., Ltd.

[0045] The protein powder was soy protein powder purchased from Shandong Yuxin Biotechnology Co., Ltd.

[0046] The inactivated Lactobacillus reuteri was purchased from Qingdao Miaopinyuan International Trade Co., Ltd.

[0047] The pH adjuster was sodium bicarbonate purchased from Tongbai Boyuan New Chemical Co., Ltd.

[0048] The composite plant powder is a compound of konjac powder, lotus root powder, yam powder and hericium erinaceus powder.

[0049] Konjac flour was purchased from Zhejiang Shangfang Biotechnology Co., Ltd.

[0050] The lotus root powder was purchased from Xinghua Lvshuai Food Co., Ltd.

[0051] The yam powder was purchased from Xi'an Tianyi Biotechnology Co., Ltd.

[0052] Hericium erinaceus powder was purchased from Xi'an Tianyi Biotechnology Co., Ltd.

[0053] The composite plant extract is a combination of Glehnia littoralis extract, Psoralea corylifolia extract and Glehnia littoralis extract.

[0054] The extract of Adenophora dahurica was purchased from Xi'an Ruierli Bioengineering Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0055] The paulownia scoparia extract was purchased from Shaanxi Bocuijian Biotechnology Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0056] The extract of Glehnia littoralis was purchased from Baoji Cosmeco Cosmetics Raw Material Development Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0057] The preparation method of the inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology is as follows: Weigh 1kg of whole milk powder, 0.9kg of L-glutamine, 0.4kg of soy protein powder, 0.01kg of inactivated Lactobacillus reuteri, 0.15kg of sodium bicarbonate, 0.4kg of konjac flour, 0.4kg of lotus root powder, 0.37kg of yam powder, 0.37kg of Hericium erinaceus powder, 0.57kg of Glehnia littoralis extract, 0.25kg of Psoralea corylifolia extract, and 0.74kg of Glehnia littoralis extract, put them into a stirring kettle, rotate at 240r / min, stir for 30min, and mix evenly to obtain an inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology.

[0058] Example 3 An inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology comprises the following components: Milk powder, L-glutamine, protein powder, inactivated Lactobacillus reuteri, pH adjuster, compound plant powder, compound plant extract.

[0059] The milk powder is whole milk powder purchased from Fonterra Cooperative Group Limited.

[0060] L-Glutamine was purchased from Hebei Huayang Biotechnology Co., Ltd.

[0061] The protein powder was soy protein powder purchased from Shandong Yuxin Biotechnology Co., Ltd.

[0062] The inactivated Lactobacillus reuteri was purchased from Qingdao Miaopinyuan International Trade Co., Ltd.

[0063] The pH adjuster was sodium bicarbonate purchased from Tongbai Boyuan New Chemical Co., Ltd.

[0064] The composite plant powder is a compound of konjac powder, lotus root powder, yam powder and hericium erinaceus powder.

[0065] Konjac flour was purchased from Zhejiang Shangfang Biotechnology Co., Ltd.

[0066] The lotus root powder was purchased from Xinghua Lvshuai Food Co., Ltd.

[0067] The yam powder was purchased from Xi'an Tianyi Biotechnology Co., Ltd.

[0068] Hericium erinaceus powder was purchased from Xi'an Tianyi Biotechnology Co., Ltd.

[0069] The composite plant extract is a combination of Glehnia littoralis extract, Psoralea corylifolia extract and Glehnia littoralis extract.

[0070] The extract of Adenophora dahurica was purchased from Xi'an Ruierli Bioengineering Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0071] The paulownia scoparia extract was purchased from Shaanxi Bocuijian Biotechnology Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0072] The extract of Glehnia littoralis was purchased from Baoji Cosmeco Cosmetics Raw Material Development Co., Ltd. It is a water-soluble extract with an extraction ratio of 10:1.

[0073] The preparation method of the inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology is as follows: Weigh 1.1kg of whole milk powder, 1kg of L-glutamine, 0.5kg of soy protein powder, 0.011kg of inactivated Lactobacillus reuteri, 0.16kg of sodium bicarbonate, 0.42kg of konjac flour, 0.42kg of lotus root powder, 0.39kg of yam powder, 0.39kg of Hericium erinaceus powder, 0.59kg of Adenophora adenophora extract, 0.27kg of Psoralea corylifolia extract, and 0.76kg of Glehnia littoralis extract, put them into a stirring kettle, rotate at 240r / min, stir for 30min, and mix evenly to obtain an inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology.

[0074] Comparative Example 1 A sterilized bacteria composition based on ultra-high temperature instantaneous sterilization processing technology, compared with Example 2, the only difference is: In the composite plant extract, an equal amount of Dendrobium officinale extract is used to replace Adenophora adenophora extract.

[0075] The Dendrobium officinale extract was purchased from Shanxi Zhongnuo Biotechnology Co., Ltd.

[0076] Comparative Example 2 A sterilized bacteria composition based on ultra-high temperature instantaneous sterilization processing technology, compared with Example 2, the only difference is: In the complex plant extract, clove extract is used to replace the pau choko extract in an equal amount.

[0077] Clove extract was purchased from Xi'an Wuling Biotechnology Co., Ltd.

[0078] Comparative Example 3 A sterilized bacteria composition based on ultra-high temperature instantaneous sterilization processing technology, compared with Example 2, the only difference is: In the composite plant extract, an equal amount of seabuckthorn extract is used to replace the wormwood extract.

[0079] Seabuckthorn extract was purchased from Xi'an Ruierli Bioengineering Co., Ltd.

[0080] Comparative Example 4 A sterilized bacteria composition based on ultra-high temperature instantaneous sterilization processing technology, compared with Example 2, the only difference is: In the composite plant extract, an equal amount of Dendrobium officinale extract is used to replace the Glehnia littoralis extract, an equal amount of Clove extract is used to replace the Psoralea corylifolia extract, and an equal amount of Hippophae rhamnoides extract is used to replace the Salvia officinalis extract.

[0081] The Dendrobium officinale extract was purchased from Shanxi Zhongnuo Biotechnology Co., Ltd.

[0082] Clove extract was purchased from Xi'an Wuling Biotechnology Co., Ltd.

[0083] Seabuckthorn extract was purchased from Xi'an Ruierli Bioengineering Co., Ltd.

[0084] Experiment 1 A number of volunteers were recruited and their blood was drawn to measure their Helicobacter pylori antibodies, which were recorded as initial Helicobacter pylori antibodies. The Helicobacter pylori antibodies of all volunteers were ≥300 mg / L.

[0085] The volunteers were randomly divided into groups of 10 people each, and took the inactivated bacteria composition based on the ultra-high temperature instantaneous sterilization processing technology of each embodiment and comparative example once a day. When taking it, 5.56g of the inactivated bacteria composition based on the ultra-high temperature instantaneous sterilization processing technology and 150ml of room temperature water were taken, mixed evenly, and drunk directly.

[0086] After taking the medicine for 90 consecutive days, blood was drawn again to measure the volunteers' Helicobacter pylori antibodies, which was recorded as the Helicobacter pylori antibodies after 90 days of conditioning.

[0087] After taking the medicine for 90 consecutive days, the volunteers stopped taking the medicine and lived and ate freely. After 90 days, blood was drawn again to measure the volunteers' Helicobacter pylori antibodies to observe whether there was a recurrence, which was recorded as the Helicobacter pylori antibody after 90 days of stopping the medicine.

[0088] The experimental data of each group were averaged.

[0089] The specific test data of Experiment 1 are shown in Table 1.

[0090] Table 1 According to the data comparison of each embodiment and comparative example in Table 1, each embodiment and comparative example can reduce the Helicobacter pylori antibody in the blood to a normal level after continuous use for 90 days. However, after stopping use for 90 days, the volunteers taking each comparative example all showed a relapse phenomenon, and the Helicobacter pylori antibody in the blood increased significantly. It can be seen that each embodiment can more thoroughly eliminate Helicobacter pylori in the body, while each comparative example cannot more thoroughly eliminate Helicobacter pylori in the body.

[0091] Each comparative ratio adopts other gastrointestinal conditioning plant extracts to replace the Glehnia littoralis extract, Psoralea corylifolia extract and Glehnia littoralis extract of the embodiment alone or in whole. Therefore, each comparative ratio can reduce the number of Helicobacter pylori in the body during continuous use. However, the compounding of other extracts cannot stimulate and promote Helicobacter pylori to leave the gastrointestinal mucosal tissue, resulting in Helicobacter pylori that is parasitic deeper and more firmly being difficult to be eliminated through the adsorption of inactivated Lactobacillus reuteri. It is proved that only when Glehnia littoralis extract, Psoralea corylifolia extract and Glehnia littoralis extract are compounded, can they stimulate Helicobacter pylori based on their synergistic effect, promote Helicobacter pylori to leave the gastrointestinal mucosal tissue, and thus be more easily adsorbed by inactivated Lactobacillus reuteri and excreted from the body, thereby achieving the effect of more thoroughly eliminating Helicobacter pylori.

[0092] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A sterilized bacteria composition based on ultra-high temperature instantaneous sterilization processing technology, characterized in that: The composition includes the following components in parts by weight: 0.9-1.1 parts of milk powder; L-glutamine 0.8-1 part; 0.3-0.5 portions of protein powder; 0.009-0.011 parts of inactivated Lactobacillus reuteri; pH regulator 0.14-0.16 parts; 1.46-1.62 parts of compound plant powder; 1.5-1.62 parts of compound plant extract; The composite plant powder is a compound of konjac powder, lotus root powder, yam powder and hericium erinaceus powder; The composite plant extract is a compound of Glehnia littoralis extract, Psoralea corylifolia extract and Psoralea corylifolia extract.

2. The inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology according to claim 1, characterized in that: The mass ratio of the Adenophora adenophora extract, the Psoralea corylifolia extract and the Psoralea corylifolia extract is 0.55-0.59:0.23-0.27:0.72-0.

76.

3. The inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology according to claim 2, characterized in that: The mass ratio of the konjac flour, lotus root flour, yam flour and hericium erinaceus flour is 0.38-0.42: 0.38-0.42: 0.35-0.39: 0.35-0.

39.

4. The inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology according to claim 3, characterized in that: The Glehnia littoralis extract, Psoralea corylifolia extract and Glehnia littoralis extract are all water-soluble extracts.

5. The inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology according to claim 1, characterized in that: The pH regulator is sodium bicarbonate.

6. The inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology according to claim 1, characterized in that: The milk powder is whole milk powder.

7. The inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology according to claim 1, characterized in that: The protein powder is soybean protein powder.

8. A sterilizing bacteria composition based on ultra-high temperature instantaneous sterilization processing technology according to any one of claims 1 to 7, characterized in that: The preparation method of the inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology is as follows: Milk powder, L-glutamine, protein powder, inactivated Lactobacillus reuteri, pH regulator, composite plant powder and composite plant extract are weighed and mixed evenly to obtain an inactivated bacteria composition based on ultra-high temperature instantaneous sterilization processing technology.

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