Preparation process of compound cordyceps sinensis preparation

Abstract

The invention provides a preparation process of a compound cordyceps sinensis preparation and belongs to the technical field of traditional Chinese medicine preparation. Comprising a freeze dryer body, a glass cover is placed on the top of the freeze dryer body, and a lifting disc is attached to the inner wall of a sliding sleeve; and the detection assembly is used for detecting whether the freeze-dried extract meets the requirements or not, and the detection assembly is connected with the lifting disc. Through the arrangement of the detection assembly, the extracting solution is placed on the containing disc in the freeze dryer, after the freeze dryer works for a period of time, the extracting solution is in a solidified state, and the bottoms of the test needles are in contact with the extracting solution, so that defective extracts can be detected; and the friction force can be increased after the test needle enters due to the disorder of the internal structure, so that the unqualified extract can be taken out and attached to the bottom of the test needle, the extract can be separated before the freeze dryer finishes working, and the influence on the quality of the extract in a normal state is reduced.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicine preparation, and in particular to a preparation process of a compound cordyceps preparation. Background Art

[0002] The preparation process of compound Cordyceps preparation is a preparation process of compound Chinese medicine preparation, which involves mixing multiple Chinese medicinal materials in a specific ratio and making the final preparation product through a series of process steps. This process usually includes steps such as raw material preparation, extraction, concentration, drying, crushing, mixing, granulation, tableting or capsule filling.

[0003] One of the above steps is drying, specifically placing the extract inside a freeze dryer for drying so that it forms an object shape for the next step. The existing method of use is to collect the extracts one by one and place them on a receiving plate in the freeze dryer. Each collecting plate is provided with a number of small squares. After the glass cover is covered, it is slightly shaken to ensure sealing. Then the freeze dryer is started, and different temperatures and drying times are selected according to the requirements of the preparation. Finally, after the drying is completed, the glass cover is removed and the drying condition of the extract is observed and detected.

[0004] During the whole process, the liquid is freeze-dried into a solid, and its internal structure after being converted into a solid cannot be observed with the naked eye. In addition, the entire freeze-drying time is relatively long, and the staff will not continuously observe the conversion process of the extract for a long time. Therefore, no matter what kind of transformation the extract undergoes in the freeze dryer, it is necessary to remove the glass cover and observe it after the freeze dryer is finished. This method easily causes the extract to change in smell and texture during the gradual solidification process due to its different water content, thereby affecting the solidification quality of the extract in adjacent small squares in the freeze dryer. Therefore, the present application provides a preparation process for a compound Cordyceps preparation to meet the needs. Summary of the invention

[0005] The technical problem to be solved by the present invention is to provide a preparation process of a compound Cordyceps preparation to solve the problem that the existing liquid is freeze-dried into a solid, the internal structure of the solid after being converted into a solid cannot be observed by the naked eye, the entire freeze-drying time is long, and the staff cannot continuously observe the conversion process of the extract for a long time.

[0006] In order to solve the above technical problems, the present invention provides the following technical solutions:

[0007] A preparation process of a compound Cordyceps sinensis preparation comprises the following steps:

[0008] Step 1: Raw material preparation and pretreatment: Select high-quality raw materials such as Cordyceps militaris, Chinese yam, Coix seeds, etc., and wash, dry and crush them;

[0009] Step 2: Extraction: Mix the crushed raw materials with an appropriate amount of solvent (such as water or ethanol) to obtain the effective ingredients. During the extraction, there will be soaking, decoction or reflux extraction to fully extract the effective ingredients;

[0010] Step 3, concentration: the extract is passed through a concentration device (vacuum concentrator) under low temperature conditions to reduce the destruction of heat-sensitive components;

[0011] Step 4, drying: The concentrated extract needs to be dried. Use a freeze dryer or a spray dryer according to the preparation requirements. Place the extract on the tray inside the freeze dryer. After fixing the outer glass cover of the freeze dryer, go through a series of programs on the freeze dryer and select the process that meets your requirements, such as freezing time, freezing temperature, etc. After meeting the requirements, take out the freeze-dried extract, observe the surface or use tools to detect the freezing effect of the extract, and proceed to the next process after meeting the standards;

[0012] Step 5: Crushing and sieving: Use an ultrafine grinder to crush the qualified extracts to increase the surface area, improve the solubility and bioavailability of the active ingredients. After the crushing, you can choose whether to perform the sieving process according to the preparation requirements;

[0013] Step 6: Mixing: Evenly mix the crushed extract with excipients (such as fillers, binders, disintegrants, etc.) to facilitate the next step of preparation molding;

[0014] Step 7: Granulation: Granulate the mixed materials using a wet granulator or a dry granulator.

[0015] Step 8, tableting or capsule filling: perform the operation according to the requirements. If tablets are to be prepared, the prepared granules are tableted. If capsules are to be prepared, the prepared powder is filled into capsule shells.

[0016] Step 9: Packaging: Packing the prepared compound cordyceps agent, usually including inner packaging and outer packaging, to protect the product from contamination and physical damage;

[0017] Step 10: Quality Control: From step 1 to step 9, the entire process needs to be quality controlled, including raw material inspection, intermediate inspection and finished product inspection, to ensure that the product quality meets the standards;

[0018] Step 11: Stability test: Conduct a stability test on the prepared compound cordyceps agent to evaluate its stability during storage.

[0019] Optionally, the freeze dryer comprises a freeze dryer body, a glass cover is placed on the top of the freeze dryer body, a support frame is fixedly connected to the top of the freeze dryer body, a placement plate is installed in the middle of the support frame, a sliding sleeve is slidably connected to the top of the glass cover, and a lifting plate is attached to the inner wall of the sliding sleeve;

[0020] A detection component is used to detect whether the freeze-dried extract meets the requirements, and the detection component is connected to the lifting plate.

[0021] Optionally, the detection component includes a connecting column fixedly connected to the bottom of the lifting plate, the bottom of the connecting column is fixedly connected to a test pin, the bottom of the test pin is fixedly connected to a limiting outer tube, the groove of the limiting outer tube is fixedly connected to a limiting arc plate, the bottom of the limiting outer tube is fixedly connected to a sliding frame, and the outer wall of the limiting outer tube is provided with a snap-in hole.

[0022] Optionally, a clamping piece is fixedly connected to the inner wall of the sliding frame, a notch is provided on the outer wall of the sliding frame, and a weakened portion is provided in the middle of the clamping piece.

[0023] Optionally, a handrail is fixedly connected to the top of the sliding sleeve, a sealing gasket is fixedly connected to the top of the glass cover, and an L-shaped support block is fixedly connected to the inner wall of the support frame.

[0024] Optionally, a curved plate is fixedly connected to the side of the sliding sleeve, a downward-pressed bent plate is fixedly connected to the bottom of the curved plate, and a downward-pressed bent plate is fixedly connected to the bottom of the L-shaped support block.

[0025] Optionally, a force distribution plate is fixedly connected to the bottom of the sliding sleeve, a second elastic sheet is fixedly connected to the bottom of the force distribution plate, and a limiting sheet is fixedly connected to the side of the support frame.

[0026] Optionally, the sealing gasket is made of rubber, a middle portion of the sealing gasket is hollow, and a top portion of the sealing gasket is fixed to an outer wall of the sliding sleeve.

[0027] Optionally, the bottom of the sliding frame is made of rubber material, and the rest of the sliding frame is made of plastic material.

[0028] Optionally, the engaging piece is made of plastic, and the size of the middle portion is matched with the size of the engaging hole.

[0029] Compared with the prior art, the present invention has at least the following beneficial effects:

[0030] In the above scheme, by setting up a detection component, the extract is placed on a serving plate inside the freeze dryer, and then a glass cover is put on to ensure sealing. The freeze dryer is started. After the freeze dryer has been working for a period of time, the extract is in a solidified state, and the bottom of the test needle can be used to contact the extract. If the solidification state of the extract is good, the bottom of the test needle will be smoother when penetrating into the extract, and the internal structure will be evenly distributed when the extract is solidified. If the solidification state of the extract is poor, the bottom of the test needle will be hindered when penetrating into the extract, and the internal structure will be chaotic when the extract is solidified, so that problematic extracts can be detected, and the chaotic internal structure will increase the friction of the test needle after entering, so that the unqualified extract will be taken out and attached to the bottom of the test needle, so that qualified and unqualified extracts can be separated before the freeze dryer ends, reducing the impact on the quality of the extract in a normal state.

[0031] By arranging a sliding frame and a snap-in piece in the detection component, in the initial state, the snap-in piece is snap-into the snap-in hole on the outer wall of the bottom end of the test needle. When the test needle gradually penetrates into the extract, the bottom of the sliding frame will contact the surface of the extract and move upward under the action of pressure, and drive the snap-in piece. At this time, the snap-in piece will be separated from the snap-in hole under the upward pressure, so that the sliding frame as a whole will slide upward. After the test needle is detected, when it is gradually pulled out from the extract, the pressure is weakened, so that the sliding frame will descend under the action of gravity, and after the bottom of the test needle is separated from the extract, the bottom of the sliding frame will descend to the same height as the bottom of the test needle. At this time, the inner wall of the sliding frame will slide and rub against the outer wall of the test needle to scrape off the extract residue attached to the test needle, so as to avoid the bottom of the test needle containing residues from the previous extract in the next detection, thereby avoiding affecting its quality.

[0032] By setting the first elastic sheet, the downward pressure bent plate and the second elastic sheet, when the sliding sleeve slides down, the arc plate will be driven to descend, and then the downward pressure bent plate will be synchronously descended, and the downward pressure bent plate will contact and press against the top of the lifting plate. Since the top of the lifting plate is fixedly connected to the bottom of the first elastic sheet, pressing the lifting plate will cause the first elastic sheet to stretch and deform. At this time, the detection component will drop with the lifting plate, and the force distribution plate will also drop with the descent of the sliding sleeve. The second elastic sheet will shrink synchronously with the force distribution plate under the action of pressure. The expansion and contraction of the first elastic sheet and the second elastic sheet can alleviate the release and transmission of force, reduce the situation where the staff manually presses the sliding sleeve to cause uneven force and seriously damage the extract, and avoid the extract from directly cracking due to excessive force after the test needle contacts the extract, thereby affecting the subsequent processing of the extract. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] The accompanying drawings, which are incorporated herein and constitute a part of the specification, illustrate embodiments of the invention and, together with the description, further serve to explain the principles of the invention and to enable those skilled in the relevant art to make and use the invention.

[0034] Figure 1 It is a three-dimensional structural diagram of the preparation process of the compound Cordyceps preparation;

[0035] Figure 2 It is a schematic diagram of the cross-sectional three-dimensional structure of the preparation process of the compound Cordyceps preparation;

[0036] Figure 3 It is a schematic diagram of the enlarged three-dimensional structure of the glass cover, the support frame and the sliding sleeve;

[0037] Figure 4 It is an enlarged three-dimensional structural diagram of the sliding sleeve, L-shaped support block and connecting column;

[0038] Figure 5 for Figure 4 A in the middle is an enlarged schematic diagram of the three-dimensional structure;

[0039] Figure 6 for Figure 4 The enlarged three-dimensional structure diagram at B in the middle;

[0040] Figure 7 It is a schematic diagram of the enlarged three-dimensional structure of the connection column and the test needle;

[0041] Figure 8 This is an enlarged three-dimensional structural diagram of the sliding frame, the card connector and the slot.

[0042] Reference numerals:

[0043] 1. Freeze dryer body; 2. Glass cover; 3. Support frame; 4. Handrail; 5. Sealing pad; 6. Sliding sleeve; 601. Arc plate; 602. First elastic sheet; 603. Downward bending plate; 604. Force distribution plate; 605. Second elastic sheet; 606. Limiting sheet; 7. L-shaped supporting block; 8. Connecting column; 801. Test pin; 802. Limiting arc sheet; 803. Limiting outer tube; 804. Sliding frame; 805. Card-connecting sheet; 806. Notch; 807. Weakened part.

[0044] As shown in the figure, in order to clearly implement the structure of the embodiment of the present invention, specific structures and devices are marked in the figure, but this is only for illustrative purposes and is not intended to limit the present invention to the specific structure, device and environment. According to specific needs, ordinary technicians in this field can adjust or modify these devices and environments. DETAILED DESCRIPTION

[0045] The following is a detailed description of the preparation process of a compound Cordyceps preparation provided by the present invention in conjunction with the accompanying drawings and specific embodiments. At the same time, it is explained here that in order to make the embodiments more detailed, the following embodiments are the best and preferred embodiments, and those skilled in the art may also adopt other alternatives to implement some known technologies; and the accompanying drawings are only for a more specific description of the embodiments, and are not intended to specifically limit the present invention.

[0046] It should be noted that the references to "one embodiment", "an embodiment", "an exemplary embodiment", "some embodiments" and the like in the specification indicate that the embodiments described may include specific features, structures or characteristics, but not every embodiment may include the specific features, structures or characteristics. In addition, when a specific feature, structure or characteristic is described in conjunction with an embodiment, it should be within the knowledge of a person skilled in the art to implement such feature, structure or characteristic in conjunction with other embodiments (whether or not explicitly described).

[0047] In general, a term can be understood, at least in part, from its use in context. For example, depending, at least in part, on the context, the term "one or more" as used herein can be used to describe any feature, structure, or characteristic in the singular sense, or can be used to describe a combination of features, structures, or characteristics in the plural sense. Additionally, the term "based on" can be understood as not necessarily intended to convey an exclusive set of factors, but can instead, depending, at least in part, on the context, allow for the presence of other factors that are not necessarily explicitly described.

[0048] It will be understood that the meanings of “on,” “over,” and “above” in the present invention should be interpreted in the broadest manner, so that “on” not only means “directly on” something, but also includes the meaning of being “on” something with intervening features or layers therebetween, and “on” or “over” not only means “on” or “above” something, but also includes the meaning of being “on” or “above” something with no intervening features or layers therebetween.

[0049] Additionally, spatially relative terms such as "under," "beneath," "lower," "above," "upper," and the like may be used herein for descriptive convenience to describe the relationship of one element or feature to another element or features, as shown in the accompanying drawings. Spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the accompanying drawings. The device may be oriented in other ways, and the spatially relative descriptors used herein may be similarly interpreted accordingly.

[0050] like Figure 1 As shown, an embodiment of the present invention provides a process for preparing an industrial paint, comprising the following steps:

[0051] Step 1: Raw material preparation and pretreatment: Select high-quality raw materials such as Cordyceps militaris, Chinese yam, Coix seeds, etc., and wash, dry and crush them;

[0052] Step 2: Extraction: Mix the crushed raw materials with an appropriate amount of solvent (such as water or ethanol) to obtain the effective ingredients. During the extraction, there will be soaking, decoction or reflux extraction to fully extract the effective ingredients;

[0053] Step 3, concentration: the extract is passed through a concentration device (vacuum concentrator) under low temperature conditions to reduce the destruction of heat-sensitive components;

[0054] Step 4, drying: The concentrated extract needs to be dried. Use a freeze dryer or a spray dryer according to the preparation requirements. Place the extract on the tray inside the freeze dryer. After fixing the outer glass cover of the freeze dryer, go through a series of programs on the freeze dryer and select the process that meets your requirements, such as freezing time, freezing temperature, etc. After meeting the requirements, take out the freeze-dried extract, observe the surface or use tools to detect the freezing effect of the extract, and proceed to the next process after meeting the standards;

[0055] Step 5: Crushing and sieving: Use an ultrafine grinder to crush the qualified extracts to increase the surface area, improve the solubility and bioavailability of the active ingredients. After the crushing, you can choose whether to perform the sieving process according to the preparation requirements;

[0056] Step 6: Mixing: Evenly mix the crushed extract with excipients (such as fillers, binders, disintegrants, etc.) to facilitate the next step of preparation molding;

[0057] Step 7: Granulation: Granulate the mixed materials using a wet granulator or a dry granulator.

[0058] Step 8, tableting or capsule filling: perform the operation according to the requirements. If tablets are to be prepared, the prepared granules are tableted. If capsules are to be prepared, the prepared powder is filled into capsule shells.

[0059] Step 9: Packaging: Packing the prepared compound cordyceps agent, usually including inner packaging and outer packaging, to protect the product from contamination and physical damage;

[0060] Step 10: Quality Control: From step 1 to step 9, the entire process needs to be quality controlled, including raw material inspection, intermediate inspection and finished product inspection, to ensure that the product quality meets the standards;

[0061] Step 11: Stability test: Conduct a stability test on the prepared compound cordyceps agent to evaluate its stability during storage.

[0062] In this embodiment, if Figures 1 to 8 As shown, the freeze dryer includes a freeze dryer body 1, a glass cover 2 is placed on the top of the freeze dryer body 1, a support frame 3 is fixedly connected to the top of the freeze dryer body 1, a placement plate is installed in the middle of the support frame 3, a sliding sleeve 6 is slidably connected to the top of the glass cover 2, and a lifting plate is attached to the inner wall of the sliding sleeve 6; a detection component, the detection component is used to detect whether the freeze-dried extract meets the requirements, the detection component is connected to the lifting plate, a handrail 4 is fixedly connected to the top of the sliding sleeve 6, a sealing gasket 5 is fixedly connected to the top of the glass cover 2, an L-shaped support block 7 is fixedly connected to the inner wall of the support frame 3, and the detection component includes a fixed connection on the lifting plate The connecting column 8 at the bottom of the lowering plate and the bottom of both ends of the handrail 4 are fixed to the top of both ends of the sliding sleeve 6, and the outer wall of the handrail 4 is fixedly connected to the middle of the top of the sealing gasket 5, and the bottom of the sealing gasket 5 is fixed to the top of the glass cover 2. When the handrail 4 and the sliding sleeve 6 slide up and down, the top of the sealing gasket 5 will rise and fall with the handrail 4. At this time, the sealing gasket 5 will not move with the rise and fall of the sliding sleeve 6, and its main moving range is the fold in the middle of the sealing gasket 5. This structure is used with the detection component, and when in use, it does not affect the normal operation of the detection component, and can also ensure the original sealing of the freeze dryer body 1, thereby improving the overall practicality of the device.

[0063] like Figures 3 to 6As shown, the side of the sliding sleeve 6 is fixedly connected with an arc plate 601, the bottom of the arc plate 601 is fixedly connected with a downward bending plate 603, the bottom of the L-shaped support block 7 is fixedly connected with the downward bending plate 603, the bottom of the sliding sleeve 6 is fixedly connected with a force distribution plate 604, the bottom of the force distribution plate 604 is fixedly connected with a second elastic sheet 605, the side of the support frame 3 is fixedly connected with a limiting sheet 606, the sliding sleeve 6 is I-shaped and slides on the outer wall of the support frame 3, the arc plate 601 is fixed to the side of the sliding sleeve 6, the downward bending plate 603 is fixed to the bottom of the arc plate 601 and is made of plastic, the top of the first elastic sheet 602 is fixed to the bottom of the L-shaped support block 7, and the bottom of the first elastic sheet 602 is fixed to the top of the lifting plate, in the initial state, the bottom of the downward bending plate 603 does not contact the top of the lifting plate, and the An elastic sheet 602 is in a natural state. When the sliding sleeve 6 slides downward on the outer wall of the support frame 3, it will drive the arc plate 601 to move, and the arc plate 601 will drive the downward pressure bent plate 603 to contact the top of the lifting plate. At this time, the lifting plate will gradually descend after being contacted and pressed by the downward pressure bent plate 603. When the lifting plate descends, the first elastic sheet 602 will be stretched downward by the lifting plate and gradually straightened, and there is a certain friction between the edge of the lifting plate and the inner wall of the support frame 3. The stretching of the first elastic sheet 602 and the friction between the lifting plate and the inner wall of the support frame 3 can alleviate the downward force of the sliding sleeve 6 to a certain extent. This effect can prevent the staff from manually pressing down the sliding sleeve 6 due to excessive force, resulting in damage to the first elastic sheet 602 and inability to effectively reset it. This can further improve the detection of the extract and avoid excessive damage to the extract.

[0064] The force distribution plate 604 is fixed to the bottom of the sliding sleeve 6, the top of the second elastic sheet 605 is fixed to the bottom of the force distribution plate 604, the bottom of the second elastic sheet 605 is fixed to the top of the freeze dryer body 1, and the outer wall of the middle part of the limit sheet 606 is fixed to the side of the support frame 3. When the sliding sleeve 6 is pressed downward, the force distribution plate 604 will be driven to press downward. At this time, the second elastic sheet 605 will shrink and deform due to the downward movement of the force distribution plate 604, so that the sliding sleeve 6 continues to move downward under the force. There are some wrinkles in the middle of the elastic sheet 605, which will move closer to the inner wall of the limiting sheet 606 after shrinkage. The outwardly wrapped shape of the limiting sheet 606 can protect the wrinkled part of the middle of the second elastic sheet 605 after shrinkage, and the opening size inside the sliding sleeve 6 is larger than the part of the limiting sheet 606 that bends outward, so that the descent of the sliding sleeve 6 will not affect the use of (606), and further can avoid the force distribution plate 604 from constantly squeezing the deformed second elastic sheet 605 during the downward pressing process, thereby causing additional damage to the second elastic sheet 605.

[0065] like Figures 7 and 8As shown, the bottom of the connecting column 8 is fixedly connected with a test needle 801, the bottom of the test needle 801 is fixedly connected with a limiting outer tube 803, the groove of the limiting outer tube 803 is fixedly connected with a limiting arc piece 802, the bottom of the limiting outer tube 803 is fixedly connected with a sliding frame 804, the outer wall of the limiting outer tube 803 is provided with a snap-in hole, the inner wall of the sliding frame 804 is fixedly connected with a snap-in piece 805, the outer wall of the sliding frame 804 is provided with a notch 806, and the middle part of the snap-in piece 805 is provided with a weakened part 807, the connecting column 8 is fixed to the bottom of the lifting plate, the top of the test needle 801 is fixed to the bottom of the connecting column 8, the inner circumference of the bottom of the limiting outer tube 803 is fixed to the middle part of the test needle 801, the bottom of the limiting arc piece 802 is fixed on the outer wall of the limiting outer tube 803, and the sliding frame 804 is provided with a slot 806. The frame 804 is slidably connected to the outer wall of the limiting outer tube 803. When the lifting plate moves vertically, it will drive the connecting column 8 and the test needle 801 to move vertically. At this time, the bottom of the test needle 801 will contact the surface of the extract and will penetrate into the extract under the action of pressure. After the bottom of the sliding frame 804 contacts the extract, it will move in the opposite direction under the interaction force, that is, the sliding frame 804 starts to move upward and will contact the top of the limiting outer tube 803 and the top of the limiting arc piece 802 that are bent outward. At this time, the inner wall of the top of the sliding frame 804 is closely fitted with the limiting arc piece 802 and the outer wall of the limiting outer tube 803, thereby being able to limit the sliding frame 804, thereby reducing the damage to the extract caused by excessive force during testing.

[0066] Furthermore, the engaging piece 805 is fixed on the inner wall of the sliding frame 804, and the engaging piece 805 is convex in shape, the convex part is consistent with the size of the engaging hole opened on the outer wall of the limiting outer tube 803, the notch 806 is opened on the outer wall of the sliding frame 804, and the weakened part 807 is weakened at the upper part of the convex position of the engaging piece 805. When the connecting column 8 and the test needle 801 are driven and pressed downward, the bottom of the test needle 801 first contacts the surface of the extract, and after continuously piercing into the extract, the bottom of the sliding frame 804 begins to contact the extract, and then the interaction force causes the sliding frame 804 to begin to Move upward, and the snap-fit ​​piece 805 will easily deform by utilizing the weak position of the weakened portion 807 when the sliding frame 804 moves upward, thereby separating the protruding portion of the snap-fit ​​piece 805 from the snap-fit ​​hole of the limiting outer tube 803. At this time, the sliding frame 804 has no other snap-fit ​​structure, and only relies on the fit between its top inner wall and the limiting outer tube 803 and the top outer wall of the limiting arc piece 802 to increase the friction force, thereby reducing the descending effect. This is beneficial to the limiting effect of the sliding frame 804, thereby ensuring that the test needle 801 does not excessively damage the extract during the descent process, which is beneficial to the subsequent production of the extract.

[0067] The working principle of the technical solution provided by the present invention is as follows:

[0068] First, the staff collects the extract completed in the previous process, and uses relevant tools such as a collection dish to hold it, and then manually places it on the holding plate on the support frame 3. After arranging it evenly, the glass cover 2 is covered to ensure good sealing, and then the freeze dryer body 1 is started.

[0069] After starting the freeze dryer body 1, it is necessary to wait for a while to ensure that the extract is cured normally. The initial curing state of the extract can be seen by observing inward through the glass cover 2. If there is any curing, at this time, you can hold the middle part of the handrail 4 and press it down hard. The sliding sleeve 6 will be clamped on the outer wall of the support frame 3 and slide down. At this time, the arc plate 601 fixed on the side of the sliding sleeve 6 will also be driven along with it, and the top of the downward pressing bent plate 603 is fixed to the bottom of the arc plate 601, so that the downward movement of the sliding sleeve 6 will drive the arc plate 601 and the downward pressing bent plate 603 to move downward synchronously, and the bottom of the downward pressing bent plate 603 will contact and press the top of the lifting plate, so that the lifting plate moves downward. While the lifting plate moves downward, since the bottom of the lifting plate is fixedly connected with the first elastic sheet 602, the first elastic sheet 602 is stretched. Under the action of the L-shaped support block 7, the maximum tension of the first elastic sheet 602 is its straightened state.

[0070] At this time, when the sliding sleeve 6 is pressed downward, the force distribution plate 604 will move downward synchronously. A second elastic sheet 605 is fixed to the bottom of the force distribution plate 604, and the second elastic sheet 605 will also be driven to be compressed and move downward. During the compression process, the second elastic sheet 605 has a wrinkled part in the middle, so that it will extend to both sides of the middle part during the downward compression and contraction process. The limiting sheet 606 fixed to the bottom side of the support frame 3 can limit the extended part in the middle when the second elastic sheet 605 is compressed, and cooperate with the upper and lower bending shape of the limiting sheet 606 to ensure to the greatest extent that the part of the second elastic sheet 605 extending outward when compressed will not be greatly deformed.

[0071] When the downward bending plate 603 contacts the lifting plate and is pressed down, the connecting column 8 at the bottom of the lifting plate will drive the test needle 801 to move downward. During the downward movement of the test needle 801, the needle tip at its bottom will contact the surface of the extract and will continuously penetrate into the interior of the extract. When the test needle 801 penetrates the surface of the extract, the bottom end of the sliding frame 804 will also contact the surface of the extract. Since a snap-fit ​​piece 805 is fixedly distributed on the inner wall of the sliding frame 804, and a weakening portion 807 is provided at the middle and upward part of the snap-fit ​​piece 805, when the bottom end of the sliding frame 804 contacts the extract, due to the interaction force, the sliding frame 804 moves in the opposite direction, that is, the upward direction. During the movement of the sliding frame 804 in the opposite direction, the weakening portion 807 will hit the snap-fit ​​hole at the lower part of the limiting outer tube 803. The weakening portion 807 can make the snap-fit ​​piece 8 The middle part of 05 can easily break away from the engaging hole of the limiting outer tube 803, so that the entire sliding frame 804 can move upward, and when the test needle 801 continues to go deeper downward, the sliding frame 804 continues to rise in the opposite direction. When the top of the inner wall of the sliding frame 804 contacts the outer wall of the limiting outer tube 803 and the outer wall of the limiting arc piece 802, since the circumference of the outer wall of the limiting outer tube 803 and the outer wall of the limiting arc piece 802 are both larger than the inner wall of the sliding frame 804, the sliding frame 804 is restricted in the process of gradually rising because it cannot continue to expand. This effect, combined with the contraction of the second elastic sheet 605 and the stretching of the first elastic sheet 602, can ensure to the maximum extent that the bottom of the test needle 801 at the pressing end will not be subjected to excessive force when it contacts the extract and damage the extract during the pressing process, thereby effectively protecting the quality of the extract during the testing stage.

[0072] After the test is completed, the hand releases the handrail 4. At this time, the second elastic sheet 605 will rebound due to the lack of force. During the rebound, the sliding sleeve 6 will also be driven to move upward and return to the initial state. The upward movement of the sliding sleeve 6 will cause no contact between the downward bending plate 603 and the lifting plate. The first elastic sheet 602 has a wrinkled part in the middle in the initial state. During the rebound process of the sliding sleeve 6, the first elastic sheet 602 will also bend and rebound to a certain extent. At this time, the lifting plate in contact with the bottom of the first elastic sheet 602 will also rise to its original position, and the bottom of the lifting plate is fixed with the connecting column 8 and the test needle 801, and then the test needle 801 gradually moves out. The inner surface of the extract slides out, that is, the test needle 801 is no longer pressed downward, and the test needle 801 that is no longer pressed downward will not drive the sliding frame 804 to move in the opposite direction. Similarly, at this time, the test needle 801 moves upward, and the sliding frame 804 moves downward due to gravity. The snap-fit ​​piece 805 will be driven downward by the sliding frame 804 and enter the snap-fit ​​hole at the bottom of the limiting outer tube 803. During this process, the inner ring at the bottom of the sliding frame 804 will slide and rub against the bottom of the test needle 801. This effect can scrape out the extract residue at the bottom of the test needle 801, and can prevent the next process from being infected by the new extract.

[0073] After the above process inspection is completed, the change process of the extract can be continued to be observed. And during the inspection, there is no need to shut down the freeze dryer, so that the quality of the solidified extract can be tested while ensuring the solidification of the extract, which reflects the practicality of the device and improves work efficiency.

[0074] The present invention covers any substitution, modification, equivalent method and scheme made on the essence and scope of the present invention. In order to make the public have a thorough understanding of the present invention, specific details are described in detail in the following preferred embodiments of the present invention, but those skilled in the art can fully understand the present invention without the description of these details. In addition, in order to avoid unnecessary confusion about the essence of the present invention, well-known methods, processes, procedures, components and circuits are not described in detail.

[0075] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A process for preparing a compound Cordyceps preparation, characterized in that: The following steps are involved: Step 1: Raw material preparation and pretreatment: Select high-quality raw materials such as Cordyceps militaris, Chinese yam, Coix seeds, etc., and wash, dry and crush them; Step 2: Extraction: Mix the crushed raw materials with an appropriate amount of solvent (such as water or ethanol) to obtain the effective ingredients. During the extraction, there will be soaking, decoction or reflux extraction to fully extract the effective ingredients; Step 3, concentration: the extract is passed through a concentration device (vacuum concentrator) under low temperature conditions to reduce the destruction of heat-sensitive components; Step 4, drying: The concentrated extract needs to be dried. Use a freeze dryer or a spray dryer according to the preparation requirements. Place the extract on the tray inside the freeze dryer. After fixing the outer glass cover of the freeze dryer, go through a series of programs on the freeze dryer and select the process that meets your requirements, such as freezing time, freezing temperature, etc. After meeting the requirements, take out the freeze-dried extract, observe the surface or use tools to detect the freezing effect of the extract, and proceed to the next process after meeting the standards; Step 5: Crushing and sieving: Use an ultrafine grinder to crush the qualified extracts to increase the surface area, improve the solubility and bioavailability of the active ingredients. After the crushing, you can choose whether to perform the sieving process according to the preparation requirements; Step 6: Mixing: Evenly mix the crushed extract with excipients (such as fillers, binders, disintegrants, etc.) to facilitate the next step of preparation molding; Step 7: Granulation: Granulate the mixed materials using a wet granulator or a dry granulator. Step 8, tableting or capsule filling: perform the operation according to the requirements. If tablets are to be prepared, the prepared granules are tableted. If capsules are to be prepared, the prepared powder is filled into capsule shells. Step 9: Packaging: Packing the prepared compound cordyceps agent, usually including inner packaging and outer packaging, to protect the product from contamination and physical damage; Step 10: Quality Control: From step 1 to step 9, the entire process needs to be quality controlled, including raw material inspection, intermediate inspection and finished product inspection, to ensure that the product quality meets the standards; Step 11: Stability test: Conduct a stability test on the prepared compound cordyceps agent to evaluate its stability during storage.

2. The process for preparing the compound Cordyceps sinensis preparation according to claim 1, characterized in that: The freeze dryer comprises a freeze dryer body, a glass cover is placed on the top of the freeze dryer body, a support frame is fixedly connected to the top of the freeze dryer body, a placement plate is installed in the middle of the support frame, a sliding sleeve is slidably connected to the top of the glass cover, and a lifting plate is attached to the inner wall of the sliding sleeve; The detection component is used to detect whether the freeze-dried extract meets the requirements, and the detection component is connected to the lifting plate.

3. The process for preparing the compound Cordyceps sinensis preparation according to claim 2, characterized in that: The detection component includes a connecting column fixedly connected to the bottom of the lifting plate, a test pin fixedly connected to the bottom of the connecting column, a limiting outer tube fixedly connected to the bottom of the test pin, a limiting arc plate fixedly connected to the groove of the limiting outer tube, a sliding frame fixedly connected to the bottom of the limiting outer tube, and a snap-in hole is opened on the outer wall of the limiting outer tube.

4. The process for preparing the compound Cordyceps sinensis preparation according to claim 3, characterized in that: The inner wall of the sliding frame is fixedly connected with a clamping piece, the outer wall of the sliding frame is provided with a notch, and the middle part of the clamping piece is provided with a weakened part.

5. The process for preparing the compound Cordyceps sinensis preparation according to claim 2, characterized in that: A handrail is fixedly connected to the top of the sliding sleeve, a sealing pad is fixedly connected to the top of the glass cover, and an L-shaped supporting block is fixedly connected to the inner wall of the supporting frame.

6. The process for preparing the compound Cordyceps sinensis preparation according to claim 5, characterized in that: The side surface of the sliding sleeve is fixedly connected with an arc plate, the bottom of the arc plate is fixedly connected with a downward pressing bent plate, and the bottom of the L-shaped support block is fixedly connected with a downward pressing bent plate.

7. The process for preparing the compound Cordyceps preparation according to claim 6, characterized in that: The bottom of the sliding sleeve is fixedly connected with a force distribution plate, the bottom of the force distribution plate is fixedly connected with a second elastic sheet, and the side of the support frame is fixedly connected with a limiting sheet.

8. The process for preparing the compound Cordyceps sinensis preparation according to claim 5, characterized in that: The sealing gasket is made of rubber, the middle part of the sealing gasket is hollow, and the top of the sealing gasket is fixed to the outer wall of the sliding sleeve.

9. The process for preparing the compound Cordyceps sinensis preparation according to claim 3, characterized in that: The bottom of the sliding frame is made of rubber material, and the rest of the sliding frame is made of plastic material.

10. The process for preparing the compound Cordyceps sinensis preparation according to claim 4, characterized in that: The clamping piece is made of plastic, and the size of the middle portion is matched with the size of the clamping hole.

Images