Method, device and program product for evaluating pulmonary circulation time based on contrast agent enhanced EIT

Abstract

The invention relates to the field of intelligent medical treatment, in particular to a method, equipment and program product for evaluating pulmonary circulation time based on contrast agent enhanced EIT. Comprising the following steps: S1, acquiring lung EIT data, enhanced by a contrast agent, of a tester; s2, determining lung circulation starting time and lung perfusion ending time based on the lung EIT data enhanced by the contrast agent; the pulmonary circulation starting time is the moment when an electrical impedance signal of a contrast agent is changed when a tester holds breath, and the pulmonary perfusion ending time is the moment when the electrical impedance signal is not changed after the contrast agent is injected when the tester holds breath; s3, the pulmonary circulation starting time is subtracted from the pulmonary perfusion ending time to obtain the pulmonary circulation time, bedside detection can be achieved through the pulmonary circulation time evaluation method, operation is convenient, and good clinical application value is achieved.

Description

Technical Field

[0001] The present application relates to the field of intelligent medical treatment, and specifically to a method, device, program product and computer-readable storage medium for evaluating pulmonary circulation time based on contrast agent enhanced EIT. Background Art

[0002] Pulmonary Transit Time (PTT) refers to the time it takes for blood to travel from the right ventricle of the heart through the pulmonary artery to the pulmonary capillary network, and then from the pulmonary capillary network to the left atrium via the pulmonary vein. PTT mainly evaluates the functional status of the cardiopulmonary vascular system, especially the hemodynamic characteristics of the pulmonary circulation, such as pulmonary vascular resistance, blood flow velocity, right heart function, etc., and is of great value for the diagnosis and monitoring of pulmonary vascular diseases such as pulmonary embolism and pulmonary hypertension. In the case of pulmonary embolism, the thrombus blocks the pulmonary artery or its branches, resulting in obstruction of blood flow in the affected area. Therefore, it takes longer for blood to pass through the obstructed pulmonary vascular bed, resulting in prolonged PTT; in the state of pulmonary hypertension, pulmonary vascular resistance increases, pulmonary artery pressure increases, resulting in a slower speed of blood passing through the pulmonary vascular bed, causing a prolonged PTT. At present, the main methods for evaluating PTT in clinical practice include radionuclide scanning, CT perfusion imaging, magnetic resonance imaging (MRI) and echocardiography. Nuclear scanning uses radioactive tracers to provide reliable regional information, but it involves radiation exposure; CT perfusion imaging has high spatial resolution and can obtain anatomical and functional information at the same time, but it also has radiation issues; MRI is radiation-free and has good repeatability, but the examination time is long and it is not suitable for bedside use; echocardiography is noninvasive and portable, but it is highly operator-dependent and requires high clinical resources. Therefore, a PTT calculation method that is suitable for bedside use, radiation-free, and simple to operate is needed.

[0003] In addition, pulmonary regional perfusion time (PRPT) involves the residence time of blood in a specific area of ​​the lung, which is a complex medical imaging and analysis problem. Uneven distribution of pulmonary blood flow may lead to insufficient oxygen exchange in certain areas, affecting overall respiratory function. In clinical practice, evaluating PRPT helps to diagnose and monitor pulmonary hemodynamic abnormalities such as pulmonary embolism, pulmonary vascular disease, chronic obstructive pulmonary disease (COPD), etc. Traditional methods such as pulmonary ventilation / perfusion scanning or CT scanning can provide information, but may not be accurate enough or difficult to monitor in real time. With the development of medical imaging technology, especially computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET), the assessment of pulmonary perfusion has become more refined, but the technical challenges that remain mainly include how to accurately and in real time measure and analyze blood flow in various regions of the lungs, and how to reduce errors and improve image quality in various imaging technologies. Summary of the invention

[0004] In view of the above problems, the present invention provides a method for evaluating pulmonary circulation time based on contrast agent enhanced EIT, which specifically includes: S1. Obtaining contrast-enhanced lung EIT data of the test subject; S2. Determine the pulmonary circulation start time and the pulmonary perfusion end time based on the contrast agent-enhanced pulmonary EIT data; the pulmonary circulation start time is the moment when the electrical impedance signal of the contrast agent injected changes when the tester holds his breath, and the pulmonary perfusion end time is the moment when the electrical impedance signal does not change after the contrast agent is injected when the tester holds his breath; S3. Subtract the pulmonary circulation start time from the pulmonary perfusion end time to obtain the pulmonary circulation time.

[0005] Further, the time when the change occurs is the time when the impedance curve decreases and the slope of the impedance curve is negative during breath holding, with the average value of the impedance at the end of N breaths before breath holding as the baseline, and N is a natural number greater than 1; Optionally, the impedance curve decreases by 5%-10% during breath holding; Optionally, the average value of the end-of-breath impedance of 3-5 breaths before breath-holding is used as the baseline; Optionally, the moment when no change occurs is the moment when the slope of the impedance curve is positive and the value is less than 0.01.

[0006] The method further includes evaluating the regional circulation time of the left and right lungs, and performing the left lung regional circulation time evaluation or the right lung regional circulation time evaluation according to the EIT data change of the contrast agent in the left lung or the right lung; Optionally, the left lung regional circulation time is obtained by determining the left lung circulation start time and the left lung circulation end time in the left lung EIT data, and then subtracting the left lung circulation start time from the left lung circulation end time; Optionally, the left lung circulation start time is the moment when the slope of the left lung impedance curve is negative during breath holding, and the left lung circulation end time is the moment when the slope of the left lung impedance curve is positive during breath holding; Optionally, the right lung regional cycle time is obtained by determining the right lung cycle start time and the right lung cycle end time in the right lung EIT data, and then subtracting the right lung cycle start time from the right lung cycle end time.

[0007] Optionally, the right lung circulation start time is the moment when the slope of the right lung impedance curve is negative during breath holding, and the right lung circulation end time is the moment when the slope of the right lung impedance curve is positive during breath holding.

[0008] The method also includes regional circulation time of the front and back lungs, and the front lung regional circulation time evaluation or the back lung regional circulation time evaluation is performed according to the EIT data change of the contrast agent in the front lung or the back lung.

[0009] Optionally, the anterior lung regional cycle time is obtained by determining the anterior lung cycle start time and the anterior lung cycle end time in the anterior lung EIT data, and then subtracting the anterior lung cycle start time from the anterior lung cycle end time.

[0010] Optionally, the start time of the front lung circulation is the moment when the slope of the front lung impedance curve is negative during breath holding, and the end time of the front lung circulation is the moment when the slope of the front lung impedance curve is positive during breath holding.

[0011] Optionally, the posterior lung regional circulation time is obtained by determining the posterior lung circulation start time and the posterior lung circulation end time in the posterior lung EIT data, and then subtracting the posterior lung circulation start time from the posterior lung circulation end time.

[0012] Optionally, the start time of the posterior pulmonary circulation is the moment when the slope of the posterior pulmonary impedance curve is negative during breath holding, and the end time of the posterior pulmonary circulation is the moment when the slope of the posterior pulmonary impedance curve is positive during breath holding.

[0013] The object of the present invention is to provide a computer program product having a computer program or instructions thereon, comprising: the computer program or instructions are executed by a processor to implement the above-mentioned method for evaluating pulmonary circulation time based on contrast agent enhanced EIT.

[0014] An object of the present invention is to provide a computer device for evaluating pulmonary circulation time based on contrast-enhanced EIT, comprising a memory and a processor and a computer program or instructions stored on the memory, wherein the computer program or instructions are executed by the processor to implement the above-mentioned method for evaluating pulmonary circulation time based on contrast-enhanced EIT.

[0015] The object of the present invention is to provide a computer-readable storage medium having a computer program or instructions stored thereon, including: the computer program or instructions are executed by a processor to implement the above-mentioned method for evaluating pulmonary circulation time based on contrast agent enhanced EIT.

[0016] The present invention proposes an imaging method for lung regional perfusion time image, which specifically includes: Obtain information on lung circulation time and lung regional location; Functional image reconstruction is performed based on the lung circulation time and lung region position information to obtain a lung region perfusion time image.

[0017] The functional image reconstruction utilizes a reconstruction algorithm to perform data reconstruction.

[0018] Optionally, the pulmonary circulation time is obtained by one or more of the following methods: obtaining the pulmonary circulation time by radionuclide scanning, obtaining the pulmonary circulation time by CT perfusion imaging, obtaining the pulmonary circulation time by magnetic resonance imaging, and obtaining the pulmonary circulation time by echocardiography.

[0019] Optionally, the method of acquiring the lung region position information includes: Acquire lung imaging data; Lung region position information is obtained by extracting position information based on the lung image data.

[0020] Optionally, the image data includes one or more of the following: radionuclide scanning images, CT perfusion images, magnetic resonance images, and ultrasound images.

[0021] Optionally, the lung medical image data also includes EIT images.

[0022] Optionally, the pulmonary circulation time is obtained by the above-mentioned method for evaluating pulmonary circulation time based on contrast agent enhanced EIT; Optionally, the lung region position information is obtained by using EIT data in the above-mentioned method for evaluating pulmonary circulation time based on contrast agent enhanced EIT.

[0023] The object of the present invention is to provide a computer program product having a computer program or instructions thereon, including: the computer program or instructions are executed by a processor to implement the above-mentioned imaging method of lung regional perfusion time image.

[0024] The object of the present invention is to provide an imaging device for lung regional perfusion time images, comprising a memory and a processor and a computer program or instructions stored in the memory, wherein the computer program or instructions are executed by the processor to implement the above-mentioned imaging method for lung regional perfusion time images.

[0025] The object of the present invention is to provide a computer-readable storage medium having a computer program or instruction stored thereon, including: the computer program or instruction is executed by a processor to implement the above-mentioned imaging method of lung regional perfusion time image.

[0026] The object of the present invention is to provide a method for evaluating regional perfusion time based on a lung regional perfusion time image, comprising: Obtaining a lung regional perfusion time image according to the above-mentioned lung regional perfusion time image imaging method; selecting a lung region based on the lung region perfusion time image; The number of pixels and pixel values ​​in the lung region are calculated to obtain the time when perfusion occurs in the lung region.

[0027] Optionally, the lung region is a region of any size; Optionally, the lung region includes one or more of the following: the entire lung region, the left lung region, the right lung region, the front lung region, and the back lung region.

[0028] The object of the present invention is to provide a computer program product having a computer program or instructions thereon, comprising: the computer program or instructions are executed by a processor to implement the above-mentioned regional perfusion time assessment method based on lung regional perfusion time image.

[0029] The object of the present invention is to provide a regional perfusion time assessment device based on a lung regional perfusion time image, comprising a memory and a processor and a computer program or instructions stored on the memory, wherein the computer program or instructions are executed by the processor to implement the above-mentioned regional perfusion time assessment method based on a lung regional perfusion time image.

[0030] The object of the present invention is to provide a computer-readable storage medium having a computer program or instruction stored thereon, including: the computer program or instruction is executed by a processor to implement the above-mentioned regional perfusion time assessment method based on lung regional perfusion time image.

[0031] Advantages of the present invention: 1. A pulmonary circulation time assessment process based on contrast-enhanced EIT was proposed. Compared with traditional pulmonary circulation assessment methods, it is radiation-free, low-cost, portable, and can be performed at the bedside and frequently, which is helpful for real-time observation of lung diseases.

[0032] 2. The pulmonary circulation time of the present invention can not only evaluate the overall pulmonary circulation time PTT, but also analyze the pulmonary circulation time of the left and right lungs according to clinical conditions (such as unilateral pulmonary embolism). In addition, it can also obtain the pulmonary circulation time of the front lung and the back lung, as well as the circulation time of any lung area according to needs, which is helpful for accurate regional detection of the onset area of ​​pulmonary disease, improves the diagnosis of targeted problem areas, and provides a potential new means for the diagnosis and monitoring of pulmonary circulation diseases.

[0033] 3. A lung regional perfusion time imaging method is proposed. A new functional map is obtained by image reconstruction based on the lung regional position information and lung circulation time. Each pixel represents the time required for blood or contrast agent to reach different areas. A lung regional perfusion time functional map is constructed, which is beneficial for subsequent lung disease monitoring and diagnosis.

[0034] 4. The functional image of lung regional perfusion time imaging can visually observe the duration of lung regional perfusion in the test subject, which helps the doctor understand the lung condition of the test subject and shorten the diagnosis time. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for use in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative work.

[0036] Figure 1 A schematic flow chart of a method for evaluating pulmonary circulation time based on contrast agent enhanced EIT provided in an embodiment of the present invention; Figure 2 A schematic diagram of a system for evaluating pulmonary circulation time based on contrast agent enhanced EIT provided in an embodiment of the present invention; Figure 3 A schematic diagram of a device for evaluating pulmonary circulation time based on contrast agent enhanced EIT provided in an embodiment of the present invention; Figure 4 A schematic diagram of determining the cycle time of the entire lung region provided by an embodiment of the present invention; Figure 5 A schematic diagram of determining the circulation time of the left and right lungs provided by an embodiment of the present invention; Figure 6 A schematic diagram of determining the circulation time of the front and rear lungs provided by an embodiment of the present invention; Figure 7 A schematic flow chart of an imaging method for a lung regional perfusion time image provided by an embodiment of the present invention; Figure 8 A schematic diagram of an imaging system for a lung regional perfusion time image according to an embodiment of the present invention; Fig. 9 A schematic diagram of an imaging device for a lung regional perfusion time image provided by an embodiment of the present invention; Fig.10 A schematic diagram of a lung region perfusion time image provided by an embodiment of the present invention. DETAILED DESCRIPTION

[0037] In order to enable those skilled in the art to better understand the solutions of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0038] In some of the processes described in the specification and claims of the present invention and the above-mentioned figures, multiple operations that appear in a specific order are included, but it should be clearly understood that these operations may not be executed in the order in which they appear in this article or executed in parallel. The sequence numbers of the operations, such as S101, S102, etc., are only used to distinguish between different operations, and the sequence numbers themselves do not represent any execution order. In addition, these processes may include more or fewer operations, and these operations may be executed in sequence or in parallel. It should be noted that the descriptions of "first", "second", etc. in this article are used to distinguish different messages, devices, modules, etc., do not represent the order of precedence, and do not limit the "first" and "second" to be different types.

[0039] Figure 1 A schematic diagram of a method for evaluating pulmonary circulation time based on contrast agent enhanced EIT provided in an embodiment of the present invention specifically includes: S1: Obtain the contrast-enhanced lung EIT data of the test subject; In one embodiment, the EIT data includes one or more of the following: an EIT image, and an EIT impedance change curve.

[0040] In one specific embodiment, the process of collecting contrast-enhanced lung EIT data for a subject is as follows: First, patients were required to undergo a breath-hold test. Mechanically ventilated patients were required to adjust to full control of the ventilation mode and hold their breath for at least 10 seconds, and spontaneously breathing patients were required to hold their breath for at least 10 seconds. Second, patients were connected to a pulmonary impedance monitoring instrument, and 10 ml of 10% NaCl solution was prepared, and it was confirmed that a central venous catheter had been established. Subsequently, while initiating the breath-hold test, saline was rapidly injected through the central venous catheter, and chest impedance signals were continuously collected starting from 2 minutes before the injection, with the entire process recorded for at least 5 minutes to capture the complete pulmonary circulation impedance change process.

[0041] S2: Determine the pulmonary circulation start time and the pulmonary perfusion end time based on the contrast agent enhanced pulmonary EIT data; the pulmonary circulation start time is the moment when the electrical impedance signal of the contrast agent injected changes when the tester holds his breath, and the pulmonary perfusion end time is the moment when the electrical impedance signal does not change after the contrast agent is injected when the tester holds his breath; In one embodiment, the time when the change occurs is the time when the impedance curve decreases and the slope of the impedance curve is negative during breath holding, with the average value of the impedance at the end of N breaths before breath holding as the baseline, and N is a natural number greater than 1.

[0042] In one embodiment, the impedance curve decreases by 5%-10% during breath-holding.

[0043] In one embodiment, the average value of the end-of-breath impedance of 3-5 times before breath-holding is used as the baseline.

[0044] In one embodiment, the time when no change occurs is the time when the slope of the impedance curve is positive and the value is less than 0.01.

[0045] In a specific embodiment, according to the change of contrast agent in the EIT whole lung image, such as Figure 4 As shown in Figure 1, the start time of the pulmonary circulation is marked on the overall impedance curve: the average impedance of the three end-expiratory times before breath holding is taken as the baseline, and the time point when the impedance curve begins to drop by 5% during the breath holding phase and the slope of the curve is negative is The time point when the slope of the impedance curve is positive and the value is less than 0.01 is defined as the end of perfusion, that is, .

[0046] S3: Subtract the pulmonary circulation start time from the pulmonary perfusion end time to obtain the pulmonary circulation time.

[0047] In a specific embodiment, upon obtaining and , subtract to get the overall pulmonary circulation time .

[0048] In one embodiment, the method further includes evaluating the regional circulation time of the left and right lungs, and performing the left lung regional circulation time evaluation or the right lung regional circulation time evaluation according to the EIT data change of the contrast agent in the left lung or the right lung.

[0049] In one embodiment, the left lung regional cycle time is obtained by determining the left lung cycle start time and the left lung cycle end time in the left lung EIT data, and then subtracting the left lung cycle start time from the left lung cycle end time.

[0050] In one embodiment, the left lung cycle start time is the moment when the slope of the left lung impedance curve is negative during breath holding, and the left lung cycle end time is the moment when the slope of the left lung impedance curve is positive during breath holding.

[0051] In one embodiment, the right lung regional cycle time is obtained by determining the right lung cycle start time and the right lung cycle end time in the right lung EIT data, and then subtracting the right lung cycle start time from the right lung cycle end time.

[0052] In one embodiment, the right lung cycle start time is the moment when the slope of the right lung impedance curve is negative during breath holding, and the right lung cycle end time is the moment when the slope of the right lung impedance curve is positive during breath holding.

[0053] In one embodiment, the method further includes evaluating the regional circulation time of the anterior and posterior lungs, and evaluating the regional circulation time of the anterior lungs or the regional circulation time of the posterior lungs according to the change of EIT data of the contrast agent in the anterior lungs or the posterior lungs.

[0054] In one embodiment, the front lung region cycle time is obtained by determining the front lung cycle start time and the front lung cycle end time from the front lung EIT data, and then subtracting the front lung cycle start time from the front lung cycle end time.

[0055] In one embodiment, the start time of the front lung circulation is the moment when the slope of the front lung impedance curve is negative during breath holding, and the end time of the front lung circulation is the moment when the slope of the front lung impedance curve is positive during breath holding.

[0056] In one embodiment, the posterior lung regional circulation time is obtained by determining the posterior lung circulation start time and the posterior lung circulation end time from the posterior lung EIT data, and then subtracting the posterior lung circulation start time from the posterior lung circulation end time.

[0057] In one embodiment, the posterior pulmonary circulation start time is the moment when the slope of the posterior pulmonary impedance curve is negative during breath holding, and the posterior pulmonary circulation end time is the moment when the slope of the posterior pulmonary impedance curve is positive during breath holding.

[0058] In a specific embodiment, the PTT of the left and right lung regions is further analyzed, such as Figure 5 : According to the changes of contrast agent in the left (or right) lung image of EIT, the start time of pulmonary circulation is marked on the left (or right) lung impedance curve (or ) and end time (or ), subtract the left (or right) lung circulation time (or ),Right now , .

[0059] In a specific embodiment, the PTT of the anterior and posterior lung regions, such as Figure 6 : Based on the changes in the lung images before (or after) EIT, the start time of the pulmonary circulation is marked on the lung impedance curve before (or after) EIT. (or ) and end time (or ), subtract the anterior (or posterior) pulmonary circulation time (or ),Right now , .

[0060] In one embodiment, the present invention establishes the pulmonary circulation time through contrast-enhanced EIT data of the tester to obtain the pulmonary circulation time, and extracts the lung regional position information from the EIT data. Subsequently, image reconstruction is performed based on the pulmonary circulation time and the lung regional position information to obtain a lung regional perfusion time image; the perfusion time of each part (region) of the lung is obtained through the lung regional perfusion time image.

[0061] In one embodiment, the method for evaluating pulmonary circulation time based on contrast agent enhanced EIT of the present invention is used to obtain the circulation time of different lung regions, including but not limited to the overall lung circulation time, left lung circulation time, right lung circulation time, upper lung circulation time, and lower lung circulation time; the circulation time of the corresponding area is obtained according to the required lung area.

[0062] The disclosed embodiments of the present invention further provide a computer program product or system, including a computer program, which, when executed by a processor, implements the steps of the above-mentioned method for evaluating pulmonary circulation time based on contrast agent enhanced EIT.

[0063] Figure 2 A schematic diagram of a system for evaluating pulmonary circulation time based on contrast agent enhanced EIT provided in an embodiment of the present invention specifically includes: Acquisition unit: acquires the lung EIT data of the tester enhanced by contrast agent; Time unit: determining the pulmonary circulation start time and the pulmonary perfusion end time based on the contrast agent-enhanced pulmonary EIT data; the pulmonary circulation start time is the moment when the electrical impedance signal of the contrast agent injected changes when the tester holds his breath, and the pulmonary perfusion end time is the moment when the electrical impedance signal does not change after the contrast agent is injected when the tester holds his breath; Calculation unit: subtract the pulmonary circulation start time from the pulmonary perfusion end time to obtain the pulmonary circulation time.

[0064] Figure 3 A schematic diagram of a device for evaluating pulmonary circulation time based on contrast agent enhanced EIT provided in an embodiment of the present invention specifically includes: A memory and a processor; the memory is used to store program instructions; the processor is used to call the program instructions, and when the program instructions are executed, any one of the above-mentioned methods for evaluating pulmonary circulation time based on contrast agent enhanced EIT is performed.

[0065] The disclosed embodiments of the present invention further provide a computer-readable storage medium storing a computer program, wherein the computer program, when executed by a processor, is any one of the above-mentioned methods for evaluating pulmonary circulation time based on contrast agent enhanced EIT.

[0066] Figure 7A schematic diagram of an imaging method for a lung regional perfusion time image provided by an embodiment of the present invention specifically includes: S101: Acquire lung circulation time and lung region position information; In one embodiment, the pulmonary circulation time is obtained by one or more of the following methods: obtaining the pulmonary circulation time by radionuclide scanning, obtaining the pulmonary circulation time by CT perfusion imaging, obtaining the pulmonary circulation time by magnetic resonance imaging, and obtaining the pulmonary circulation time by echocardiography.

[0067] In one embodiment, the method of acquiring the lung region position information includes: Acquire lung imaging data; Lung region position information is obtained by extracting position information based on the lung image data.

[0068] In one embodiment, the image data includes one or more of the following: nuclear scanning images, CT perfusion images, magnetic resonance images, and ultrasound images.

[0069] In one embodiment, the lung medical image data further includes an EIT image.

[0070] In one embodiment, the pulmonary circulation time is obtained by the above-mentioned method for evaluating pulmonary circulation time based on contrast agent enhanced EIT.

[0071] In one embodiment, the lung region position information is obtained by using EIT data in the above-mentioned method for evaluating pulmonary circulation time based on contrast agent enhanced EIT.

[0072] S102: Perform functional image reconstruction based on the lung circulation time and lung region position information to obtain a lung region perfusion time image.

[0073] In one embodiment, the functional image reconstruction utilizes a reconstruction algorithm to perform data reconstruction.

[0074] The reconstruction algorithms include one or more of the following: algebraic reconstruction algorithm ART, joint algebraic reconstruction algorithm SART, slight wave back projection method FBP, iterative reconstruction algorithm, image reconstruction algorithm based on Hopfield network, image reconstruction algorithm based on steepest descent BP network, and sparse imaging method based on deep dictionary.

[0075] The basic idea of ​​the ART algorithm is to give the reconstruction area an initial value, which is generally zero, and then evenly back-project the resulting projection value residuals one by one along the direction of the ray, continuously correcting the image until the required requirements are met, and then ending the iterative process‌.

[0076] The SART algorithm is the main improvement of the ART algorithm. The main difference between SART and ART is that ART only considers one ray for each correction, while SART uses the correction values ​​of all rays passing through a pixel to iterate.

[0077] The FBP algorithm was developed based on the back-projection method and solves the problem of image sharpness by adding a filter function. The FBP algorithm has a fast reconstruction speed and high image quality and is currently the most commonly used CT image reconstruction method.

[0078] Although the iterative reconstruction algorithm has a large amount of calculation and a slow reconstruction speed, its calculation results are better than the FBP algorithm in some aspects, especially in cases where there is insufficient projection data, missing projection angles, or uneven projection intervals.

[0079] In one embodiment, a method for imaging a lung region perfusion time image includes: Based on the data of radionuclide scanning, the lung region position information and lung circulation time are obtained, and the lung region perfusion time image is further constructed through the lung region position information and lung circulation time; Based on the CT perfusion data, the lung region position information and the lung circulation time are obtained, and the lung region perfusion time image is further constructed through the lung region position information and the lung circulation time; Based on the nuclear magnetic resonance data, the lung region position information and lung circulation time are obtained, and the lung region perfusion time image is further constructed through the lung region position information and lung circulation time; Based on the ultrasound data, the lung region position information and the lung circulation time are obtained, and the lung region perfusion time image is further constructed through the lung region position information and the lung circulation time; Based on the EIT data, the lung region position information and lung circulation time are obtained, and the lung region perfusion time image is further constructed through the lung region position information and lung circulation time; Based on the contrast-enhanced EIT data, the lung region position information and lung circulation time are obtained, and the lung region perfusion time image is further constructed based on the lung region position information and lung circulation time; The pulmonary circulation time is obtained based on radionuclide scanning / CT perfusion / MRI / ultrasound / EIT / contrast agent-enhanced EIT data, and the lung regional position information is obtained based on EIT / contrast agent-enhanced EIT data. The lung regional perfusion time image is further constructed based on the lung regional position information and pulmonary circulation time.

[0080] In one embodiment, the lung region perfusion time image is as follows: Fig.10As shown in the figure, each pixel point represents the time required for different areas of the blood knife. The darker the color, the longer the perfusion time of the area represented by the pixel point, and the lighter the color, the shorter the perfusion time of the area represented by the pixel point.

[0081] The disclosed embodiments of the present invention further provide a computer program product or system, including a computer program, which implements the steps of the above-mentioned imaging method of lung regional perfusion time image when executed by a processor.

[0082] Figure 8 The schematic diagram of the imaging system of the lung regional perfusion time image provided by the embodiment of the present invention specifically includes: Acquisition module: obtains lung circulation time and lung area location information; Reconstruction module: Perform functional image reconstruction based on the lung circulation time and lung region position information to obtain a lung region perfusion time image.

[0083] Fig. 9 A schematic diagram of an imaging device for a lung regional perfusion time image provided by an embodiment of the present invention specifically includes: A memory and a processor; the memory is used to store program instructions; the processor is used to call the program instructions, and when the program instructions are executed, any one of the above-mentioned imaging methods for lung regional perfusion time images is performed.

[0084] The disclosed embodiment of the present invention further provides a computer-readable storage medium storing a computer program, wherein the computer program, when executed by a processor, is any one of the above-mentioned methods for imaging lung regional perfusion time images.

[0085] An embodiment of the present invention provides a method for evaluating regional perfusion time based on a lung regional perfusion time image, comprising: Obtaining a lung regional perfusion time image according to the above-mentioned lung regional perfusion time image imaging method; selecting a lung region based on the lung region perfusion time image; The number of pixels and pixel values ​​in the lung region are calculated to obtain the time when perfusion occurs in the lung region.

[0086] In one embodiment, the lung region is a region of any size.

[0087] In one embodiment, the lung region includes one or more of the following: the entire lung region, the left lung region, the right lung region, the front lung region, and the back lung region.

[0088] In one embodiment, the perfusion time of each region of the lung of the test subject can be visually observed through the lung region perfusion time image, and the perfusion time of the corresponding region can be accurately calculated according to needs.

[0089] The disclosed embodiments of the present invention further provide a computer program product or system, including a computer program, which, when executed by a processor, implements the steps of the above-mentioned regional perfusion time assessment method based on lung regional perfusion time images.

[0090] An embodiment of the present invention provides a computer device, specifically comprising: A memory and a processor; the memory is used to store program instructions; the processor is used to call the program instructions, and when the program instructions are executed, any one of the above-mentioned regional perfusion time assessment methods based on lung regional perfusion time images is executed.

[0091] An embodiment of the present invention provides a computer-readable storage medium storing a computer program. When the computer program is executed by a processor, any one of the above-mentioned regional perfusion time assessment methods based on lung regional perfusion time images is implemented.

[0092] The verification results of this verification embodiment show that assigning inherent weights to indications can improve the performance of the method relative to the default setting. Those skilled in the art can clearly understand that for the convenience and simplicity of description, the specific working processes of the systems, devices and units described above can refer to the corresponding processes in the aforementioned method embodiments, and will not be repeated here. In the several embodiments provided in this application, it should be understood that the disclosed systems, devices and methods can be implemented in other ways. For example, the device embodiments described above are only schematic, for example, the division of the units is only a logical function division, and there may be other division methods in actual implementation, such as multiple units or components can be combined or integrated into another system, or some features can be ignored or not executed. Another point is that the coupling or direct coupling or communication connection between each other shown or discussed can be through some interfaces, indirect coupling or communication connection of devices or units, which can be electrical, mechanical or other forms. The unit described as a separate component may or may not be physically separated, and the component displayed as a unit may or may not be a physical unit, that is, it may be located in one place, or it may be distributed on multiple network units. Some or all of the units can be selected according to actual needs to achieve the purpose of the scheme of this embodiment. In addition, each functional unit in each embodiment of the present invention may be integrated into one processing unit, or each unit may exist physically separately, or two or more units may be integrated into one unit. The above-mentioned integrated unit may be implemented in the form of hardware or in the form of software functional units. A person of ordinary skill in the art may understand that all or part of the steps in the various methods of the above-mentioned embodiments may be completed by instructing the relevant hardware through a program, and the program may be stored in a computer-readable storage medium, and the storage medium may include: a read-only memory (ROM), a random access memory (RAM), a disk or an optical disk, etc.

[0093] A person of ordinary skill in the art can understand that all or part of the steps in the above-mentioned embodiment method can be implemented by instructing related hardware through a program, and the program can be stored in a computer-readable storage medium. The above-mentioned medium storage can be a read-only memory, a disk or an optical disk, etc.

[0094] The above is a detailed introduction to a computer device provided by the present invention. For a person skilled in the art, according to the concept of the embodiments of the present invention, there may be changes in the specific implementation method and application scope. In summary, the content of this specification should not be understood as limiting the present invention.

Claims

1. A method for evaluating pulmonary circulation time based on contrast agent enhanced EIT, characterized in that: include: S1. Obtaining contrast-enhanced lung EIT data of the test subject; S2. Determine the pulmonary circulation start time and the pulmonary perfusion end time based on the contrast agent-enhanced pulmonary EIT data; the pulmonary circulation start time is the moment when the electrical impedance signal of the contrast agent injected changes when the tester holds his breath, and the pulmonary perfusion end time is the moment when the electrical impedance signal does not change after the contrast agent is injected when the tester holds his breath; S3. Subtract the pulmonary circulation start time from the pulmonary perfusion end time to obtain the pulmonary circulation time.

2. The method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to claim 1, characterized in that: The moment of change is the moment when the impedance curve decreases and the slope of the impedance curve is negative during breath holding, with the average value of the impedance at the end of N breaths before breath holding as the baseline, and N is a natural number greater than 1; Optionally, the impedance curve decreases by 5%-10% during breath holding; Optionally, the average value of the end-of-breath impedance of 3-5 breaths before breath-holding is used as the baseline; Optionally, the moment when no change occurs is the moment when the slope of the impedance curve is positive and the value is less than 0.

01.

3. The method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to claim 1, characterized in that: The method further includes evaluating the regional circulation time of the left and right lungs, and performing the left lung regional circulation time evaluation or the right lung regional circulation time evaluation according to the EIT data change of the contrast agent in the left lung or the right lung; Optionally, the left lung regional circulation time is obtained by determining the left lung circulation start time and the left lung circulation end time in the left lung EIT data, and then subtracting the left lung circulation start time from the left lung circulation end time; Optionally, the left lung circulation start time is the moment when the slope of the left lung impedance curve is negative during breath holding, and the left lung circulation end time is the moment when the slope of the left lung impedance curve is positive during breath holding; Optionally, the right lung regional circulation time is obtained by determining the right lung circulation start time and the right lung circulation end time in the right lung EIT data, and then subtracting the right lung circulation start time from the right lung circulation end time; Optionally, the right lung circulation start time is the moment when the slope of the right lung impedance curve is negative during breath holding, and the right lung circulation end time is the moment when the slope of the right lung impedance curve is positive during breath holding.

4. The method for evaluating pulmonary circulation time based on contrast agent enhanced EIT according to claim 1, characterized in that: The method further includes evaluating the regional circulation time of the front and rear lungs, and evaluating the regional circulation time of the front lungs or the regional circulation time of the rear lungs according to the changes in the EIT data of the contrast agent in the front lungs or the rear lungs; Optionally, the front lung regional circulation time is obtained by determining the front lung circulation start time and the front lung circulation end time from the front lung EIT data, and then subtracting the front lung circulation start time from the front lung circulation end time; Optionally, the start time of the front lung circulation is the moment when the slope of the front lung impedance curve is negative during breath holding, and the end time of the front lung circulation is the moment when the slope of the front lung impedance curve is positive during breath holding; Optionally, the posterior lung regional circulation time is obtained by determining the posterior lung circulation start time and the posterior lung circulation end time from the posterior lung EIT data, and then subtracting the posterior lung circulation start time from the posterior lung circulation end time; Optionally, the start time of the posterior pulmonary circulation is the moment when the slope of the posterior pulmonary impedance curve is negative during breath holding, and the end time of the posterior pulmonary circulation is the moment when the slope of the posterior pulmonary impedance curve is positive during breath holding.

5. A method for imaging lung regional perfusion time images, characterized in that: include: Obtain information on lung circulation time and lung regional location; Functional image reconstruction is performed based on the lung circulation time and lung region position information to obtain a lung region perfusion time image.

6. The method for imaging lung regional perfusion time according to claim 5, characterized in that: The functional image reconstruction utilizes a reconstruction algorithm to perform data reconstruction; Optionally, the pulmonary circulation time is obtained by one or more of the following methods: obtaining the pulmonary circulation time by radionuclide scanning, obtaining the pulmonary circulation time by CT perfusion imaging, obtaining the pulmonary circulation time by magnetic resonance imaging, and obtaining the pulmonary circulation time by echocardiography; Optionally, the method of acquiring the lung region position information includes: Acquiring lung imaging data; Extracting position information based on the lung image data to obtain lung region position information; Optionally, the image data includes one or more of the following: nuclear scanning images, CT perfusion images, magnetic resonance images, and ultrasound images; Optionally, the image data further includes an EIT image; Optionally, the pulmonary circulation time is obtained by the method for evaluating pulmonary circulation time based on contrast agent enhanced EIT as described in any one of claims 1 to 4; Optionally, the lung region position information is obtained by using EIT data in the method for evaluating pulmonary circulation time based on contrast agent enhanced EIT as described in claim 1.

7. A method for evaluating regional perfusion time based on lung regional perfusion time images, characterized in that: include: Obtaining a lung regional perfusion time image according to the imaging method of lung regional perfusion time image according to claim 5 or 6; selecting a lung region based on the lung region perfusion time image; Calculating the number of pixels in the lung region and the pixel values ​​to obtain the time when perfusion occurs in the lung region; Optionally, the lung region is a region of any size; Optionally, the lung region includes one or more of the following: the entire lung region, the left lung region, the right lung region, the front lung region, and the back lung region.

8. A computer program product having a computer program or instructions thereon, characterized in that: include: The computer program or instructions are executed by a processor to implement the method for evaluating pulmonary circulation time based on contrast agent enhanced EIT as described in any one of claims 1 to 4, or to implement the imaging method of the pulmonary regional perfusion time image as described in claim 5 or 6; or to implement the method for evaluating regional perfusion time based on the pulmonary regional perfusion time image as described in claim 7.

9. A computer device comprising a memory and a processor and a computer program or instruction stored in the memory, characterized in that: The computer program or instructions are executed by the processor to implement the method for evaluating pulmonary circulation time based on contrast agent enhanced EIT as described in any one of claims 1 to 4, or to implement the imaging method of the pulmonary regional perfusion time image as described in claim 5 or 6; or to implement the method for evaluating regional perfusion time based on the pulmonary regional perfusion time image as described in claim 7.

10. A computer-readable storage medium having a computer program or instruction stored thereon, characterized in that: include: The computer program or instructions are executed by a processor to implement the method for evaluating pulmonary circulation time based on contrast agent enhanced EIT as described in any one of claims 1 to 4, or to implement the imaging method of the pulmonary regional perfusion time image as described in claim 5 or 6; or to implement the method for evaluating regional perfusion time based on the pulmonary regional perfusion time image as described in claim 7.

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