Double-side blood pressure measuring method, system and device based on pulse and finger pressure of two hands

Abstract

The invention belongs to the technical field of medical care equipment, and particularly relates to a bilateral blood pressure measuring method, system and device based on pulse and finger pressure of both hands. The blood pressure measuring method comprises the steps that pressure signals and photoelectric pulse wave signals PPG generated when the thumb and the index finger of a user gradually pressurize and press are synchronously collected, and then peak values in the PPG signals corresponding to the pressure signals of 0 mmHg to 180 mmHg are fitted into an envelope line; the pressure signal value at the envelope peak moment is the average arterial pressure MAP, and the peak value is the pulse wave amplitude value AMAP of the average arterial pressure; then querying a blood pressure measurement normalization coefficient table to obtain a systolic pressure proportionality coefficient KSBP and a diastolic pressure proportionality coefficient KDBP corresponding to the current MAP; finally, the AMAP is multiplied by the KSBP and the KDBP to obtain the blood pressure detection process of the user. A signal detection part in the equipment comprises a pressure sensor and a photoelectric pulse sensor. The scheme of the invention has the advantages of high precision, simple measurement, good comfort and portability, and continuous measurement.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical care equipment, and specifically relates to a bilateral blood pressure measurement method based on pulse and finger pressure of both hands, and a corresponding blood pressure generation system and bilateral blood pressure detection device. Background Art

[0002] Blood pressure is a key physiological indicator that can characterize the health status of the human body. The existing technologies provide non-invasive detection methods for human blood pressure, mainly including cuff blood pressure measurement (Oscillometric Method) and cuffless blood pressure measurement. Among them, cuff blood pressure measurement is also called oscillometric method. This method calculates systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) by detecting the oscillation amplitude (Oscillometric Envelope) when the cuff is inflated and deflated. For example, U.S. Patent US20220087555 (Blood Pressure Measurement Systems and Methods) is a representative of this type of solution.

[0003] According to the difference in measurement principles, cuffless blood pressure measurement can be divided into pulse transit time method (PTT), pulse waveform analysis method (PWA) and blood pressure estimation method based on optical sensing. Among them, the pulse wave transit time method calculates the pulse wave transit time delay (PTT) by measuring the electrocardiography (ECG) and pulse signal (PPG), and then estimates the blood pressure based on the relationship between PTT and blood pressure. For example, each patent US20190119681 (Blood Pressure Measurement Using a Wearable Device) discloses such a scheme that uses ECG and PPG signals to calculate PTT and estimate blood pressure through a constructed personalized model. This scheme is suitable for continuous monitoring. The pulse waveform analysis method estimates blood pressure by analyzing the characteristics in the pulse waveform (such as amplitude, rise time, etc.). For example, the method disclosed in U.S. Patent US10702171B2 (Method and Device for Blood Pressure Estimation Using Pulse Wave Analysis) is to estimate the blood pressure value by analyzing the characteristic points of the pulse waveform (such as peaks and troughs) and then combining the algorithm. The blood pressure estimation method based on optical sensing mainly uses the changes in the photoelectric volume pulse wave to estimate blood pressure, which can be used in combination with the PTT and PWA methods. U.S. Patent US6511435B1 (Optical Sensor System for Blood Pressure Measurement) provides a related technical solution that uses optical sensors to record blood flow dynamic signals and combines light absorption models to estimate blood pressure.

[0004] Although the above methods can measure the user's blood pressure, they still have the following disadvantages: although the cuff measurement method has high accuracy, the measurement time is long and continuous monitoring is not possible; the equipment is bulky and inconvenient to wear; the cuff needs to be pressurized, which is uncomfortable. The detection accuracy of the pulse wave transmission time method is still insufficient, it is easily affected by individual differences and the external environment, and the calibration is complicated. The pulse waveform analysis method has poor accuracy, is sensitive to the extraction of waveform feature points, and is easily disturbed by motion and noise, thus affecting the measurement stability. The accuracy of the method based on optical sensing is also relatively poor, and it is easily affected by skin color, tissue thickness and ambient light, resulting in significant errors.

[0005] In summary, how to provide a blood pressure measurement solution with high accuracy, simple measurement, good comfort, good portability and continuous measurement is becoming a technical problem that needs to be solved urgently by technical personnel in this field. Summary of the invention

[0006] In order to solve the problem that existing blood pressure measurement solutions cannot achieve a balance between high accuracy, comfortable user experience, good portability and support for continuous measurement, the present invention provides a bilateral blood pressure measurement method, system and device based on bimanual pulse and finger pressure.

[0007] The present invention is implemented by the following technical solutions: A bilateral blood pressure measurement method based on pulse and finger pressure of both hands, comprising: The pressure signal and photoelectric pulse wave signal PPG are synchronously collected when the thumb and index finger of at least one side of the user's hand gradually press and increase pressure, and the interval signals of the two types of signals in the pressure signal period from 0mmHg to 180mmHg are extracted as blood pressure detection signals.

[0008] Extract each discrete peak value in the PPG signal of the blood pressure detection signal and fit it into an envelope; take the pressure signal value corresponding to the peak moment of the envelope as the mean arterial pressure MAP, and take the peak value of the envelope as the pulse wave amplitude value A of the user's current mean arterial pressure MAP .

[0009] Combined with MAP, query a blood pressure measurement normalization coefficient table to obtain the systolic blood pressure proportional coefficient K corresponding to the current MAP SBP and diastolic pressure proportionality coefficient K DBP Among them, the blood pressure measurement normalization coefficient table is a K value that is determined in advance based on experimental data and is used to characterize the MAP corresponding to different intervals. SBP and K DBP Parameter comparison table of values.

[0010] Combined with known A MAP , K SBP and K DBP The user's current systolic blood pressure amplitude A is calculated by the following formula SBP and diastolic pressure amplitude A DBP : A SBP =K SBP ×A MAP , A DBP =K DBP ×A MAP , The two are the measurement results of the blood pressure data of the corresponding side of the user.

[0011] As a further improvement of the present invention, in the blood pressure measurement normalization coefficient table provided, MAP, K SBP and K DBP The mapping relationship between the three is: When 40<MAP≤60, KSBP =0.622, K DBP =0.674, When 60<MAP≤70, K SBP =0.583, K DBP =0.692, When 70<MAP≤80, K SBP =0.524, K DBP =0.723, When 80<MAP≤100, K SBP =0.500, K DBP =0.750, When 100<MAP≤120, K SBP =0.483, K DBP =0.773, When 120<MAP≤140, K SBP =0.465, K DBP =0.795, When 140<MAP≤160, K SBP =0.458, K DBP =0.811.

[0012] As a further improvement of the present invention, during the signal acquisition stage, when the user applies pressure with the thumb and index finger, the pressure value should increase as uniformly as possible from 0 mmHg to 180 mmHg. And the pressure growth rate should be maintained within a preferred range, for example, the pressure application time should be controlled to be between 15s and 40s, at which time, the increase rate of the inter-finger pressure applied by the user is about 4.5 to 12 mmHg / s.

[0013] As a further improvement of the present invention, during the signal collection stage, the pressure values ​​of the user's thumb and index finger are visualized to guide the user to uniformly increase the applied pressure value to a specified value within a specified time period.

[0014] As a further improvement of the present invention, in the signal acquisition stage, the pressure signal and PPG signal of the user's left and right hands when pressing simultaneously are first acquired synchronously. Then, based on the pressure signals and PPG signals on both sides, the user's bilateral blood pressure data are measured respectively; the blood pressure data on each side includes a set of A SBP and A DBP The value of .

[0015] As a further improvement of the present invention, in the signal acquisition stage, one channel of pressure signal and at least two channels of PPG signals are synchronously acquired for the user's left hand and right hand, respectively. Then, a set of blood pressure data is generated based on the pressure signal of any side and each channel of PPG signal of the corresponding side, and then the multi-channel blood pressure data is weightedly fused to obtain the final blood pressure data of the corresponding side.

[0016] As a further improvement of the present invention, the method for constructing the blood pressure measurement normalization coefficient table is: (1) Using the aforementioned bilateral blood pressure measurement method based on the pulse and finger pressure of both hands, a large number of real users' blood pressure detection signals are obtained; and the real blood pressure data of the users are simultaneously measured by any existing blood pressure measurement method; and each group of corresponding blood pressure detection signals and their corresponding real blood pressure data are taken as a sample data.

[0017] (2) Using the bilateral blood pressure measurement method based on the pulse and finger pressure of both hands as mentioned above, the blood pressure detection signal in each sample data is preprocessed to determine the mean arterial pressure MAP and pulse wave amplitude value A of the corresponding user. MAP .

[0018] (3) Calculate the systolic pressure V in the real blood pressure data contained in each sample data SBP and diastolic blood pressure V DBP The value of A MAP The ratio α, β.

[0019] And combine each A MAP The associated MAP values ​​generate two two-element arrays (MAP, α) and (MAP, β).

[0020] (4) Taking each binary array as a data point, cluster analysis is performed on the large number of data points consisting of the binary array (MAP, α) and the binary array (MAP, β), and then the cluster centers of α and β when MAP belongs to different intervals are obtained, and they are used as the required systolic blood pressure proportional coefficient K. SBP and diastolic pressure proportionality coefficient K DBP .

[0021] (5) Organize the clustering results of the previous step and generate the required blood pressure measurement normalization coefficient table.

[0022] The present invention also includes a blood pressure generation system, which includes a memory, a processor, and a computer program stored in the memory and running in the processor. When the processor executes the computer program, the aforementioned bilateral blood pressure measurement method based on the pulse and finger pressure of both hands is implemented, thereby converting the input blood pressure detection signal into a value representing the current user's blood pressure data.

[0023] The present invention also includes a bilateral blood pressure detection device, which includes: a signal acquisition module, a signal transmission module and a host computer. The signal acquisition module includes two sensing sheets, each of which is provided with a pressure sensor and at least one photoelectric pulse sensor. The signal transmission module is used to achieve a communication connection between the signal acquisition module and the host computer in a wired or wireless manner, and then transmit the detection data of the pressure sensor and the photoelectric pulse sensor to the host computer in real time.

[0024] The host computer is used to adopt the bilateral blood pressure measurement method based on the pulse and finger pressure of both hands as mentioned above, and calculate the blood pressure data of either side or both sides of the user according to the pressure signals and PPG signals collected by the two sensor sheets when measuring the blood pressure of the user's left and right hands.

[0025] As a further improvement of the present invention, the host computer further includes a display. The host computer is also used to generate a visual image in real time to characterize the change of the pressure value applied by the user when the user presses the sensor sheet in the signal acquisition module to measure the blood pressure, so as to guide the user to increase the applied pressure value uniformly to a specified value within a specified time.

[0026] As a further improvement of the present invention, in order to enable each sensor sheet to obtain multiple PPG signals in a single press, the present invention provides the following two strategies: (1) Each sensing piece includes a multi-wavelength photoelectric pulse sensor. The photoelectric pulse sensor obtains a PPG signal by emitting a detection signal of each wavelength, thereby ultimately obtaining multiple PPG signals.

[0027] (2) Each sensing sheet includes a plurality of photoelectric pulse sensors located at different positions. Each independent photoelectric pulse sensor can obtain at least one PPG signal according to the detection signal emitted by itself, thereby ultimately obtaining multiple PPG signals.

[0028] The technical solution provided by the present invention has the following beneficial effects: The solution provided by the present invention can collect blood pressure data of both the left and right hands of the user at one time, and allows multi-point collection of PPG signals on each finger of the user, thereby increasing data richness. This special data collection method can use more data to improve the accuracy and reliability of measurement, and can eliminate the impact of single-point errors on blood pressure measurement. On the other hand, it can also allow users to synchronously analyze the asymmetric information implicit in the blood pressure data on the left and right sides of the user, thus having the potential to reveal more physiological lesions.

[0029] In the blood pressure measurement scheme combining pulse wave and finger pressure provided by the present invention, the estimation of MAP not only depends on the peak value of the PPG signal, but also combines the pressure applied by the finger. By fitting the relationship between the PPG signal envelope and the pressure signal, the physical pressure is directly combined with the physiological signal. This innovative method significantly improves the accuracy of blood pressure estimation. Since the hemodynamic characteristics of the PPG waveform will change significantly when affected by pressure changes, the pressure changes of the arteries can be accurately inferred through association with the pressure signal, thereby providing a more accurate MAP value and avoiding errors when using the PPG signal alone for blood pressure estimation.

[0030] The present invention uses the new blood pressure detection data to realize data processing, combining the two algorithms of inflection point method and variable amplitude coefficient method, which improves the accuracy of blood pressure estimation while ensuring the convenience of measurement. The solution also has higher universality and can widely adapt to the physiological differences of different individuals, especially for users with large blood pressure fluctuations, and can provide more stable blood pressure measurement results.

[0031] The present invention innovates the existing blood pressure measurement method. During the measurement process, the user only needs to press the sensor composed of the pressure sensor and the photoelectric pulse sensor with his fingers. The operation is simple and no complicated calibration is required. This not only improves the user's comfort, but also makes blood pressure measurement more convenient. In addition, compared with the traditional solution, the measurement process in the product of the present invention is repeated indefinitely, and the relevant instruments do not need to be restored to the state, so it is suitable for application scenarios that require long-term monitoring of the user's blood pressure. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings: Figure 1 This is a flowchart of the steps of a bilateral blood pressure measurement method based on bimanual pulse and finger pressure provided in Example 1 of the present invention.

[0033] Figure 2 This is a schematic diagram of generating a blood pressure measurement result by combining a PPG signal and a pressure signal according to Embodiment 1 of the present invention.

[0034] Figure 3 This is a flowchart of the steps of the method for constructing a normalization coefficient table for blood pressure measurement in Example 1 of the present invention.

[0035] Figure 4 This is a functional module diagram of the bilateral blood pressure detection device provided in Example 2 of the present invention.

[0036] Figure 5This is a physical picture of the signal acquisition module provided in Example 2 of the present invention.

[0037] Figure 6 This is a schematic diagram of the signal acquisition module provided in Example 2 of the present invention. DETAILED DESCRIPTION

[0038] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0039] Example 1 This embodiment provides a bilateral blood pressure measurement method based on pulse and finger pressure of both hands. This method is actually designed based on the inflection point method principle similar to that based on cuff-type blood pressure measurement. Specifically, the operating procedures and data processing methods of the cuff-type blood pressure measurement method are as follows: First, pressure is applied to the user's arm by inflating, and the pressure value and the pulse wave at the user's arm are collected synchronously during the pressure release process. After the collected pulse wave signal is filtered, the envelope of the pulse wave signal peak is fitted by the Gaussian fitting method. The fitting formula of the envelope is as follows: , In the above formula, A ( t ) represents the envelope amplitude at time t; A max Indicates the maximum amplitude of the envelope; represents the center point of the Gaussian distribution corresponding to the moment of mean arterial pressure (MAP); Represents the standard deviation of the Gaussian distribution.

[0040] Next, the first and second derivatives of the envelope are calculated to find the inflection point: , The position of the inflection point is determined by the condition that the second-order derivative is zero: , Based on the above formula, the inflection point is calculated as: , Therefore, the left turning point of the envelope is calculated as The right turning point is .

[0041] Finally, according to the relationship between the amplitude and pressure of the pulse wave signal in the cuff blood pressure measurement method, it can be determined that the pressure values ​​corresponding to the diastolic pressure (DBP) and the systolic pressure (SBP) are the pressure values ​​at the two inflection points, namely:

[0042] in, P (·) is a function that represents the change in pressure applied to the user's arm during the pressure release phase of the measurement process.

[0043] Compared with the existing cuff-type blood pressure measurement method, the bilateral blood pressure measurement method based on the pulse and finger pressure of both hands provided in this embodiment adjusts the measurement method to improve the comfort and ease of operation of the measurement process. At the same time, the new blood pressure detection signal type collected and the data processing process for generating the blood pressure detection results in this embodiment are also redesigned to ensure the accuracy of the final detection results.

[0044] Specifically, in terms of measurement specifications, the new method provided in this embodiment no longer applies external force to the user's arm, but the user's thumb and index finger actively apply pressure, and in the process of increasing the pressure from 0 to 180 mmHg, the user's fingertip pressure and pulse wave are synchronously collected. In the data processing stage, those skilled in the art found that although the fingertip pressure and pulse wave in the new measurement method also meet the similar inflection point change law in the cuff-type blood pressure measurement method, the size of the user's diastolic and systolic pressure is not directly equal to the pulse wave at the corresponding moment, but presents a more complex mapping relationship between the mean arterial pressure, pulse wave amplitude, diastolic pressure and systolic pressure. Finally, after a large amount of data analysis, this embodiment finally summarizes a special variable amplitude coefficient method, which realizes the purpose of generating the user's final blood pressure data (including diastolic pressure and systolic pressure) based on the synchronously collected fingertip pressure and pulse wave signals.

[0045] In detail, Figure 1 As shown, this embodiment provides a bilateral blood pressure measurement method based on pulse and finger pressure of both hands, including the following steps: 1. Signal acquisition: The pressure signal and photoelectric pulse wave signal PPG are synchronously collected when the thumb and index finger of at least one side of the user's hand gradually press and increase pressure, and the interval signals of the two types of signals in the pressure signal period from 0mmHg to 180mmHg are extracted as blood pressure detection signals.

[0046] This embodiment is similar to the cuff-type blood pressure measurement method, both of which apply a certain pressure to the human blood vessels and measure the diastolic and systolic blood pressure of the human body in combination with the changes in the human pulse wave during the process. The difference is that the cuff-type measurement method passively applies pressure to the artery in the arm through external action, while this embodiment actively applies pressure to the fingertip veins through the user himself. However, during the measurement process, in order to ensure the measurement accuracy, both should keep the pressure in the blood vessels uniform during the pressure application process. In the cuff-type blood pressure measurement method, the cuff is usually punched first, and after the pressure reaches the specified amplitude, it is evenly deflated so that the pressure value gradually decreases.

[0047] In the actual application of the present embodiment, the pressure signal can be collected by a thin film pressure sensor, and the pulse wave signal can be collected by a photoelectric pulse sensor. After the two sensors are integrated into one detection device, the two signals can be collected synchronously when the user presses with the thumb and index finger.

[0048] In the signal collection stage of the present embodiment, the user's thumb and index finger may be required to increase the pressure value from 0 mmHg to 180 mmHg at a uniform rate. The pressure growth rate should be maintained within a preferred range. For example, the user is required to control the pressure application time to be between 15s and 40s. At this time, the increase rate of the inter-finger pressure applied by the user is about 4.5 to 12 mmHg / s.

[0049] In actual application, in order to make the collected blood pressure monitoring signal of the PPG signal containing the pressure signal meet the requirements and thus improve the accuracy of blood pressure detection, the pressure values ​​of the user's thumb and index finger can also be visualized in combination with the collected signals to guide the user to increase the applied pressure value to a specified value at a uniform speed within a specified time. For example, the changes in the detected pressure value can be displayed in real time in the form of numbers, graphics, and charts, so that the user can feedback and control the applied pressure value, etc.

[0050] 2. Signal processing: like Figure 2 As shown, based on the blood pressure detection signal composed of the synchronized pressure signal and the photoelectric pulse wave signal PPG obtained in the signal acquisition stage, this embodiment first extracts each discrete peak value in the PPG signal of the blood pressure detection signal in the signal processing stage, and then uses the Gaussian fitting method to fit an envelope according to the coordinates of each peak point. In addition, in a more optimized solution of this embodiment, the collected PPG signal can also be first subjected to digital filtering processing, and then peak search and envelope fitting are performed.

[0051] Next, find the peak point and peak time of the fitted envelope, take the pressure signal value corresponding to the peak time of the envelope as the mean arterial pressure MAP, and take the peak value of the envelope as the pulse wave amplitude value A of the user's current mean arterial pressure MAP .

[0052] Combined with MAP, query a blood pressure measurement normalization coefficient table to obtain the systolic blood pressure proportional coefficient K corresponding to the current MAP SBP and diastolic pressure proportionality coefficient K DBP Among them, the blood pressure measurement normalization coefficient table is a K value that is determined in advance based on experimental data and is used to characterize the MAP corresponding to different intervals. SBP and K DBP Parameter comparison table of values.

[0053] Combined with known A MAP , K SBP and K DBP The user's current systolic blood pressure amplitude A is calculated by the following formula SBP and diastolic pressure amplitude A DBP : A SBP =K SBP ×A MAP , A DBP =K DBP ×A MAP , A SBP and A DBP That is the measurement result of the blood pressure data of the user's corresponding side.

[0054] It should be noted that: in the solution of this embodiment, the technicians combined the regression analysis of a large amount of real test data and found that when the user's mean arterial pressure MAP is at different levels, the systolic pressure proportional coefficient K used to calculate the amplitude of systolic pressure and diastolic pressure is SBP and diastolic pressure proportionality coefficient K DBP They are different, which is the inherent reason why the variable amplitude coefficient method needs to be adopted in the data processing stage of this embodiment.

[0055] Among them, in this embodiment, the technicians summarized a set of reliable blood pressure measurement normalization coefficients based on known sample data, MAP, K SBP and K DBP The mapping relationship between the three is shown in the following table: Table 1: Mapping relationship between normalization coefficients in the blood pressure measurement scheme combining pulse wave and finger pressure

[0056] That is: when 40<MAP≤60, then KSBP =0.622, K DBP =0.674, When 60<MAP≤70, K SBP =0.583, K DBP =0.692, When 70<MAP≤80, K SBP =0.524, K DBP =0.723, When 80<MAP≤100, K SBP =0.500, K DBP =0.750, When 100<MAP≤120, K SBP =0.483, K DBP =0.773, When 120<MAP≤140, K SBP =0.465, K DBP =0.795, When 140<MAP≤160, K SBP =0.458, K DBP =0.811.

[0057] The blood pressure measurement normalization coefficient table is a key tool for generating the final blood pressure measurement result according to the blood pressure measurement signal in this embodiment. This tool helps technicians determine the systolic blood pressure proportional coefficient K associated with the user's current mean arterial pressure MAP when generating the test result. SBP and diastolic pressure proportionality coefficient K DBP Specifically, Figure 3 As shown, the method for constructing the blood pressure measurement normalization coefficient table includes the following steps: (1) Using the aforementioned bilateral blood pressure measurement method based on pulse and finger pressure of both hands, a large number of real users' blood pressure detection signals are obtained. When collecting the blood pressure detection signals, the user's real blood pressure data is measured simultaneously by any existing blood pressure measurement method (including any of the high-precision solutions mentioned above). Each group of corresponding blood pressure detection signals and their corresponding real blood pressure data are then used as a sample data.

[0058] (2) Using the bilateral blood pressure measurement method based on the pulse and finger pressure of both hands as mentioned above, the blood pressure detection signal in each sample data is preprocessed, including fitting the envelope of the pulse wave peak value, and combining the envelope and the change curve of the pressure signal to determine the corresponding user's mean arterial pressure MAP and its pulse wave amplitude value A. MAP .

[0059] (3) Calculate the systolic pressure V in the real blood pressure data contained in each sample dataSBP and diastolic blood pressure V DBP The value of A MAP The ratio α, β.

[0060] And combine each A MAP The associated MAP values ​​generate two two-element arrays (MAP, α) and (MAP, β).

[0061] (4) Taking each binary array as a data point, cluster analysis is performed on the large number of data points consisting of the binary array (MAP, α) and the binary array (MAP, β), and then the cluster centers of α and β when MAP belongs to different intervals are obtained, and they are used as the required systolic blood pressure proportional coefficient K. SBP and diastolic pressure proportionality coefficient K DBP .

[0062] (5) Organize the clustering results of the previous step and generate the required blood pressure measurement normalization coefficient table.

[0063] It should be emphasized that the K corresponding to the different intervals of mean arterial pressure MAP in Table 1 SBP and K DBP It is just one of the mapping relationships between parameters with high reliability obtained by the technicians in this case based on the known sample data analysis. SBP and K DBP The values ​​of parameters in different MAP intervals are not used to limit this solution. A person skilled in the art may also obtain a new segmentation method and parameter value that is closer to this embodiment and has high reliability in practical applications by combining other sample data, and this should still be part of the overall technical concept of this embodiment.

[0064] Considering that the bilateral blood pressure measurement method based on two-hand pulse and finger pressure provided in this embodiment mainly relies on the user's thumb and index finger to actively press to measure blood pressure, in the actual measurement process, the user can choose either the left hand or the right hand for measurement. In addition, the user can also measure the blood pressure of the left and right hands at the same time to obtain synchronously collected bilateral blood pressure.

[0065] That is, in the signal acquisition stage, the pressure signal and PPG signal of the user's left and right hands are collected synchronously when they are pressed at the same time. Then, the user's bilateral blood pressure data are measured based on the pressure signals and PPG signals on both sides; the blood pressure data on each side includes a set of A SBP and A DBP The value of .

[0066] Based on the feature of the embodiment scheme that it is easier to achieve the synchronous measurement of bilateral blood pressure, different pressure curves and PPG waveforms can be compared and verified in real time based on the data collected on the fingers on both sides, so as to achieve more accurate blood pressure estimation. It is also possible to more accurately distinguish the possible asymmetry of blood pressure between the left and right upper limbs of the human body, and use the change law of the captured asymmetric bilateral blood pressure data to reveal certain early physiological lesions, which is a prominent advantage that other existing blood pressure measurement methods do not have.

[0067] The bilateral blood pressure measurement method based on the pulse and finger pressure of both hands provided in this embodiment mainly adopts pressure sensors and photoelectric pulse sensors for measurement in actual application. In order to overcome the defect that the accuracy of existing measurement schemes is easily affected by factors such as measurement conditions, equipment accuracy and individual differences, thereby causing errors, this embodiment can also collect multi-point data on the fingers on both sides at the same time, thereby increasing the richness of data, improving the accuracy and reliability of measurement, and eliminating the influence of single-point errors on blood pressure measurement.

[0068] For example, in the signal acquisition stage of the present embodiment, one pressure signal and at least two PPG signals are synchronously collected for the left and right hands of the user. Then, a set of blood pressure data is generated based on the pressure signal on any side and each PPG signal on the corresponding side, and then the multi-channel blood pressure data is weighted and fused to obtain the final blood pressure data on the corresponding side. In practical applications, assuming that N PPG signals can be collected on a single finger in each round of measurement, the weight of each set of data during fusion can be set to 1 / N.

[0069] In the actual application stage of the scheme of this embodiment, the work of the data processing part can be completed by a blood pressure generation system, which includes a memory, a processor, and a computer program stored in the memory and running in the processor. When the processor executes the computer program, the bilateral blood pressure measurement method based on the pulse and finger pressure of both hands as described above is implemented, and then the input blood pressure detection signal is converted into a numerical value representing the current user's blood pressure data.

[0070] The blood pressure generation system is essentially a computer device for implementing the data processing task in the aforementioned method. In actual application, the computer device can be an intelligent terminal capable of executing a program, a tablet computer, a laptop computer, a desktop computer, a rack server, a blade server, a tower server or a cabinet server (including an independent server or a server cluster composed of multiple servers), etc.

[0071] The computer device indicated in this embodiment includes at least but is not limited to: a memory and a processor that can be connected to each other through a system bus. Among them, the memory (i.e., a readable storage medium) includes a flash memory, a hard disk, a multimedia card, a card-type memory (e.g., an SD or DX memory, etc.), a random access memory (RAM), a static random access memory (SRAM), a read-only memory (ROM), an electrically erasable programmable read-only memory (EEPROM), a programmable read-only memory (PROM), a magnetic memory, a disk, an optical disk, etc. In some embodiments, the memory can be an internal storage unit of a computer device, such as a hard disk or a memory of the computer device. In other embodiments, the memory can also be an external storage device of a computer device, such as a plug-in hard disk equipped on the computer device, a smart memory card (Smart Media Card, SMC), a secure digital (Secure Digital, SD) card, a flash card (Flash Card), etc. Of course, the memory can also include both the internal storage unit of the computer device and its external storage device. In this embodiment, the memory is generally used to store an operating system and various application software installed on the computer device. In addition, the memory can also be used to temporarily store various types of data that have been output or are to be output.

[0072] The processor may be a central processing unit (CPU), a graphics processing unit (GPU), a controller, a microcontroller, a microprocessor, or other data processing chips in some embodiments. The processor is generally used to control the overall operation of a computer device. In this embodiment, the processor is used to run program codes stored in a memory or process data.

[0073] Example 2 Based on the bilateral blood pressure measurement method based on pulse and finger pressure of both hands provided in Example 1, this embodiment further provides a blood pressure measurement product capable of implementing this method; namely, a bilateral blood pressure detection device. Figure 4 As shown, the bilateral blood pressure detection device provided in this embodiment includes: a signal acquisition module, a signal transmission module and a host computer. Among them, the signal acquisition module includes two sensing sheets, each of which is provided with a pressure sensor and at least one photoelectric pulse sensor. The signal transmission module is used to realize a communication connection between the signal acquisition module and the host computer in a wired or wireless manner, and then transmit the detection data of the pressure sensor and the photoelectric pulse sensor to the host computer in real time. The host computer is used to adopt the aforementioned bilateral blood pressure measurement method based on the pulse and finger pressure of both hands, and calculate the blood pressure data of any one or both sides of the user according to the pressure signals and PPG signals collected by the two sensing sheets when measuring the blood pressure of the user's left and right hands.

[0074] Figure 5 A typical structural design of the signal acquisition module provided in this embodiment is shown. Specifically, Figure 6 As shown, the signal acquisition module includes a long strip substrate, and a sensing sheet is installed at both ends of the substrate. The sensing sheet has a double-layer structure, including a pulse wave detection unit located at the top and a pressure sensing unit located at the bottom. The pressure sensing unit adopts a thin film pressure sensor. The pulse wave detection unit includes a silver sheet with an opening and a photoelectric pulse wave sensor below it. The photoelectric pulse sensor is composed of a light-emitting diode (LED) and a photodiode (PD). The opening on the silver sheet serves as a signal transmitting window and a signal receiving window of the photoelectric pulse sensor. The photoelectric pulse sensor transmits the detection signal outward through the opening on the silver sheet, and inverts the PPG waveform caused by the blood flow change according to the received echo signal to realize pulse wave detection.

[0075] In actual application, in order to realize that each sensing piece can obtain multiple PPG signals in a single press, this embodiment provides the following two solutions. In the first solution, a multi-wavelength photoelectric pulse sensor is installed in each sensing piece, and the photoelectric pulse sensor can emit detection signals of multiple different wavelengths; by processing the echo signals of the detection signals of each wavelength emitted respectively, multiple PPG signals can be finally obtained. For example, two PPG signals can be obtained using a dual-wavelength photoelectric pulse sensor. In the second solution, each sensing piece includes multiple photoelectric pulse sensors located at different positions, and each independent photoelectric pulse sensor can obtain at least one PPG signal according to the detection signal emitted by itself, so that multiple PPG signals can be finally obtained.

[0076] In addition, the above content only introduces a device solution with two sensor chips and supporting simultaneous measurement of the user's bilateral blood pressure. In actual applications, multiple pairs of sensor chips can be integrated on a signal acquisition module. Each pair of sensor chips can support bilateral blood pressure measurement for a user, thereby realizing unilateral or bilateral blood pressure measurement for multiple users at the same time through a set of equipment.

[0077] In the bilateral blood pressure detection device of this embodiment, the signal transmission module can be connected to the host computer through a serial port wired connection, and the collected data is transmitted to the host computer in real time through the signal cable. The signal transmission module can also be wirelessly connected to the host computer through low-power Bluetooth, WIFI, Star Flash, Zigebee and other communication modules, and the collected data is sent to the host computer in real time through the wireless signal transmission module.

[0078] In the bilateral blood pressure detection device of the present embodiment, the host computer is mainly used to realize data processing of the blood pressure monitoring signal, and then obtain the blood pressure detection result. Therefore, the device can adopt various computer devices with data processing functions, such as various general computing devices, special computing devices or embedded devices, such as desktop computers, laptops, tablet computers, smart bracelets, smart watches, etc. In addition, in some schemes, the data processing tasks required to be completed by the host computer can also be implemented by cloud services. For example, the data acquisition module uploads the collected blood pressure detection signal to a cloud platform in real time through the signal transmission module, and the background server of the cloud platform completes the corresponding data processing tasks and generates the blood pressure detection results. Only the user with permission can log in to the account to query the corresponding blood pressure detection results.

[0079] As mentioned above, in the data collection stage, the user can be guided to better complete the data collection through real-time feedback of the pressure signal. In order to achieve this technical effect, the host computer in this embodiment adopts a locally deployed computer device, and the host computer also includes a display. The host computer is also used to generate a visual image in real time to characterize the change of the pressure value applied by the user when the user presses the sensor in the signal acquisition module to measure the blood pressure, so as to guide the user to increase the applied pressure value at a uniform speed to a specified size within a specified time. Among them, in the actual application stage, the visual image displayed on the display can be a curve, a numerical value, a statistical chart, or even various more intuitive bubble charts, energy display bars, pointer instrument charts, etc. that characterize the change of the pressure value.

[0080] Combined with the above introduction to the working principle and operating specifications of the bilateral blood pressure measurement method based on pulse and finger pressure of both hands and the corresponding bilateral blood pressure detection device, it can be found that compared with the existing solutions, this new blood pressure measurement solution has the following multiple advantages: This embodiment innovates the measurement method and measurement principle of blood pressure. The blood pressure detection data is obtained by synchronously collecting the PPG waveform and pressure signal when the user's thumb and index finger are pressed. This measurement method can realize the synchronous collection of data of both hands, and can realize multi-point or multi-channel collection of PPG signals on the fingers on each side. Compared with the traditional single-point measurement, the synchronous collection of both hands of the present invention can effectively reduce accidental errors and improve the stability and reliability of blood pressure measurement through rich physiological signals. In addition, after the present invention realizes the synchronous measurement of the blood pressure of the left and right upper limbs of the human body, it helps to capture the asymmetric law of bilateral blood pressure of the human body, and thus has the potential to reveal more physiological lesions. This is a special advantage that other similar devices do not have.

[0081] In this embodiment, when analyzing the blood pressure detection signal, the pressure signal is matched with the peak moment of the PPG waveform by fitting the envelope of the PPG waveform peak, and the MAP value is directly obtained. This solution combining physical pressure and physiological signals can obtain a more accurate MAP value, avoid the estimation bias in the traditional method, and enhance the accuracy of the result.

[0082] This embodiment creatively combines the variable amplitude coefficient method and the inflection point method when generating the final blood pressure test results. The variable amplitude coefficient method estimates blood pressure based on the amplitude characteristics of the PPG waveform, and the inflection point method further improves the accuracy of blood pressure estimation by analyzing the relationship between the characteristic points of the PPG waveform and the pressure value. In addition, in order to make the estimation of diastolic and systolic pressure more accurate and more efficient, this embodiment also establishes a blood pressure measurement normalization coefficient table in combination with a large amount of real data. This blood pressure measurement normalization coefficient table can help technicians scientifically determine the systolic pressure proportional coefficient K associated with the user's current mean arterial pressure MAP when generating test results. SBP and diastolic pressure proportionality coefficient K DBP .

[0083] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A bilateral blood pressure measurement method based on pulse and finger pressure of both hands, characterized in that: It includes: The pressure signal and the photoelectric pulse wave signal PPG are synchronously collected when the thumb and index finger of at least one side of the user's hand gradually press and press, and the interval signals of the two types of signals in the period from 0 mmHg to 180 mmHg of the pressure signal are extracted as blood pressure detection signals; Extract each discrete peak value in the PPG signal of the blood pressure detection signal and fit it into an envelope; take the pressure signal value corresponding to the peak moment of the envelope as the mean arterial pressure MAP, and take the peak value of the envelope as the pulse wave amplitude value A of the user's current mean arterial pressure MAP ; Combined with MAP, query a blood pressure measurement normalization coefficient table to obtain the systolic blood pressure proportional coefficient K corresponding to the current MAP SBP and diastolic pressure proportionality coefficient K DBP The blood pressure measurement normalization coefficient table is a K coefficient table determined in advance based on experimental data and used to characterize the MAP corresponding to different intervals. SBP and K DBP Parameter comparison table of values; The user's current systolic blood pressure amplitude A is calculated by the following formula: SBP and diastolic pressure amplitude A DBP , which is the blood pressure data of the user's corresponding side: A SBP =K SBP ×A MAP , A DBP =K DBP ×A MAP 。 2. The bilateral blood pressure measurement method based on pulse and finger pressure of both hands as claimed in claim 1, characterized in that: The mapping relationship of the blood pressure measurement normalization coefficient table is: When 40<MAP≤60, K SBP =0.622, K DBP =0.674, When 60<MAP≤70, K SBP =0.583, K DBP =0.692, When 70<MAP≤80, K SBP =0.524, K DBP =0.723, When 80<MAP≤100, K SBP =0.500, K DBP =0.750, When 100<MAP≤120, K SBP =0.483, K DBP =0.773, When 120<MAP≤140, K SBP =0.465, K DBP =0.795, When 140<MAP≤160, K SBP =0.458, K DBP =0.

811.

3. The method for measuring bilateral blood pressure based on pulse and finger pressure of both hands as claimed in claim 2, characterized in that: During the signal collection stage, when the user applies pressure with his thumb and index finger, the pressure value increases uniformly from 0 mmHg to 180 mmHg, and the pressure application time is 15s~40s.

4. The method for measuring bilateral blood pressure based on pulse and finger pressure of both hands as claimed in claim 3, characterized in that: During the signal collection phase, the pressure values ​​of the user's thumb and index finger are visualized to guide the user to increase the applied pressure value uniformly to a specified value within a specified time period.

5. The method for measuring bilateral blood pressure based on pulse and finger pressure of both hands as claimed in claim 1, characterized in that: In the signal collection stage, the pressure signal and PPG signal when the user's left and right hands press at the same time are collected synchronously; Then, the user's bilateral blood pressure data is measured based on the pressure signals and PPG signals on both sides; the blood pressure data on each side includes a set of A SBP and A DBP The value of .

6. The method for measuring bilateral blood pressure based on pulse and finger pressure of both hands as claimed in claim 5, characterized in that: In the signal collection stage, one channel of pressure signal and at least two channels of PPG signal are collected synchronously for the user's left hand and right hand respectively; Then, a set of blood pressure data is generated based on the pressure signal on either side and each PPG signal on the corresponding side, and then the multi-channel blood pressure data is weightedly fused to obtain the final blood pressure data on the corresponding side.

7. The method for measuring bilateral blood pressure based on pulse and finger pressure of both hands as claimed in claim 6, characterized in that: The method for constructing the blood pressure measurement normalization coefficient table is: (1) Using the bilateral blood pressure measurement method based on pulse and finger pressure of both hands as described in any one of claims 1 to 6 to obtain a large number of real users' blood pressure detection signals; and simultaneously measuring the real blood pressure data of the users by any existing blood pressure measurement method; and then taking each group of corresponding blood pressure detection signals and their corresponding real blood pressure data as a sample data; (2) Preprocess the blood pressure detection signal in each sample data to determine the corresponding user's mean arterial pressure MAP and pulse wave amplitude value A MAP ; (3) Calculate the systolic pressure V in the real blood pressure data contained in each sample data SBP and diastolic blood pressure V DBP The value of A MAP The ratios α and β; and combined with each A MAP The associated MAP values ​​generate two two-element arrays (MAP, α) and (MAP, β); (4) Perform cluster analysis on the large number of binary arrays (MAP, α) and (MAP, β) obtained, and then find the cluster centers of α and β when MAP belongs to different intervals, and use them as the required systolic blood pressure proportional coefficient K SBP and diastolic pressure proportionality coefficient K DBP ; (5) Organize the clustering results of the previous step and generate the required blood pressure measurement normalization coefficient table.

8. A blood pressure generating system comprising a memory, a processor, and a computer program stored in the memory and executed in the processor, characterized in that: When the processor executes the computer program, it implements the bilateral blood pressure measurement method based on bimanual pulse and finger pressure as described in any one of claims 1-6, and further converts the input blood pressure detection signal into a numerical value representing the current user's blood pressure data.

9. A bilateral blood pressure detection device, characterized in that: It includes: A signal acquisition module, which includes two sensing sheets, each of which is provided with a pressure sensor and at least one photoelectric pulse sensor; A signal transmission module is used to realize a communication connection between the signal acquisition module and the host computer in a wired or wireless manner, thereby transmitting the detection data of the pressure sensor and the photoelectric pulse sensor to the host computer in real time; A host computer is used to adopt the bilateral blood pressure measurement method based on double-hand pulse and finger pressure as described in any one of claims 1 to 6, and calculate the blood pressure data of any one or both sides of the user according to the pressure signals and PPG signals collected by the two sensing sheets when measuring the blood pressure of the user's left and right hands.

10. The bilateral blood pressure detection device according to claim 9, characterized in that: The host computer also includes a display, and when the user presses the sensor in the signal acquisition module to measure the blood pressure, the host computer generates a visual image in real time for representing the change of the pressure value applied by the user, so as to guide the user to increase the applied pressure value uniformly to a specified value within a specified time. or Each sensing piece includes a multi-wavelength photoelectric pulse sensor to obtain multi-channel PPG signals; or Each sensing sheet includes a plurality of photoelectric pulse sensors located at different positions to obtain multi-channel PPG signals.

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