Electrode assembly and device for electrochemically preparing artificial cornea

Abstract

The utility model provides an electrode assembly and device for electrochemically preparing an artificial cornea, and relates to the technical field of artificial cornea preparation devices. The electrode assembly comprises a cathode assembly and an anode assembly, the cathode assembly comprises a negative electrode, and the negative electrode is provided with a spherical concave part; the anode assembly comprises a positive electrode, the positive electrode is provided with a spherical convex part, the spherical convex part and the spherical concave part are arranged at intervals, the convex direction of the spherical convex part is the same as the concave direction of the spherical concave part, and both the positive electrode and the negative electrode can conduct electricity. The artificial cornea can be effectively prepared.

Description

Technical Field

[0001] The present application relates to the technical field of artificial cornea preparation devices, and in particular, to an electrode assembly and device for electrochemically preparing artificial corneas. Background Art

[0002] When a patient's cornea is severely injured, a corneal transplant is usually required for effective treatment. However, corneal donors are generally scarce, so artificial corneas have emerged to replace donor corneas.

[0003] Among the existing methods for preparing artificial corneas, there are methods for forming an artificial cornea by forming a film of collagen in a mold, and there are methods for depositing collagen on a customized electrode by an electrochemical method to form an artificial cornea. The inventors of this application have found in their research that an acidic liquid containing collagen is used as an electrolyte, and a cathode electrode and an anode electrode are inserted into the electrolyte to carry out an electrochemical reaction. The electrochemical reaction involves the process of collagen migration, collagen precipitation, and voltage compaction. Collagen is deposited in the position area where the pH is equal to the isoelectric point to form a stable film layer. When a cornea-shaped electrode is used as the cathode and a flat electrode is used as the anode, the inventors have found through experiments that it is easy to cause collagen deposition in some areas and no collagen deposition in some areas, which is not conducive to the preparation of an artificial cornea. Utility Model Content

[0004] The embodiments of the present application provide an electrode assembly and a device for electrochemically preparing an artificial cornea, which can effectively prepare an artificial cornea.

[0005] This application is implemented as follows:

[0006] In a first aspect, the present application provides an electrode assembly for electrochemically preparing an artificial cornea, comprising:

[0007] a cathode assembly, the cathode assembly comprising a cathode electrode, the cathode electrode having a spherical concave portion; and

[0008] An anode assembly, the anode assembly comprising an anode electrode, the anode electrode having a spherical protrusion, and the spherical protrusion and the spherical concave portion are arranged in alignment and at intervals, the protruding direction of the spherical protrusion is the same as the concave direction of the spherical concave portion, and both the anode electrode and the cathode electrode are capable of conducting electricity.

[0009] In a possible implementation manner, the radii of curvature of the spherical concave portion and the spherical convex portion are equal.

[0010] In a possible implementation manner, an insulating portion is further provided around the edge of the spherical recessed portion.

[0011] In a possible implementation manner, the cathode electrode includes a first deposition portion and a first connection portion disposed around the first deposition portion, the spherical recessed portion is disposed in the first deposition portion, and the insulating portion can cover the first connection portion.

[0012] In a possible implementation manner, the anode electrode includes a second deposition portion and a second connection portion disposed around the second deposition portion, and the spherical protrusion is disposed on the second deposition portion.

[0013] In a possible implementation, the cathode electrode is made of titanium, and the anode electrode is made of platinum or graphite.

[0014] In a second aspect, the present application provides a device for electrochemically preparing an artificial cornea, comprising the electrode assembly for electrochemically preparing an artificial cornea of ​​the first aspect, an electrolyte container for containing electrolyte, and a support seat installed on the electrolyte container, the cathode electrode and the anode electrode are respectively connected with a connector, and the outer surface of the connector has an insulating sleeve; the connector is slidably connected to the support seat and can be raised and lowered to adjust the distance between the spherical protrusion and the spherical recess.

[0015] In a possible implementation, the support seat has a plurality of connection holes along its thickness direction, and the connection piece is provided with a rubber ring, which can move along the length direction of the connection piece and be fixed to the outer surface of the connection piece; the connection piece can be inserted into the connection hole, and the rubber ring can abut against the connection hole to limit the lifting and lowering of the connection piece.

[0016] In a possible implementation, the connecting hole includes a first hole and a second hole coaxially arranged, and the aperture of the first hole is larger than the aperture of the second hole, the first hole and the second hole form a step, the connecting member can be inserted into the first hole and the second hole, and the rubber ring can move in the first hole and abut against the step.

[0017] In a possible implementation, it also includes a fixing piece, the inner wall of the first hole has an internal thread, the outer wall of the fixing piece has an external thread matching the internal thread of the first hole, and a through hole is provided along the height direction of the fixing piece, the connecting piece can be inserted into the through hole, the fixing piece can be threadedly connected to the first hole, and the bottom end of the fixing piece can be pressed on the rubber ring.

[0018] The embodiments of the present application have at least the following beneficial effects:

[0019] In the electrode assembly for electrochemical preparation of artificial cornea in the embodiment of the present application, both the cathode electrode and the anode electrode are conductive, and current is applied to the cathode electrode and the anode electrode by a power supply, so that collagen can be deposited on the cathode electrode. Since the cathode electrode has a spherical concave portion, and the anode electrode has a spherical convex portion, and the spherical convex portion and the spherical concave portion are arranged in an aligned and spaced manner, and the convex direction of the spherical convex portion is the same as the concave direction of the spherical concave portion, the distance between the relative positions of the spherical convex portion and the spherical concave portion is small or consistent, and collagen can be deposited on the entire area of ​​the spherical concave portion of the cathode electrode, so that an artificial cornea can be effectively prepared. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings required for use in the embodiments will be briefly introduced below. It should be understood that the following drawings only show certain embodiments of the present application and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0021] Figure 1 This is a schematic diagram of the structure of an electrode assembly according to an embodiment of the present application;

[0022] Figure 2 A top view of a cathode electrode according to an embodiment of the present application;

[0023] Figure 3 A schematic diagram of the structure of another electrode assembly according to an embodiment of the present application;

[0024] Figure 4 This is a schematic structural diagram of the device for electrochemically preparing an artificial cornea in a first state according to an embodiment of the present application;

[0025] Figure 5 It is a schematic structural diagram of the device for electrochemically preparing an artificial cornea in a second state according to an embodiment of the present application;

[0026] Figure 6 This is an exploded view of a device for electrochemically preparing an artificial cornea according to an embodiment of the present application.

[0027] Icons: 10-electrode assembly; 11-cathode assembly; 111-cathode electrode; 111a-spherical recessed portion; 1111-first deposition portion; 1112-first connecting portion; 12-anode assembly; 121-anodole; 121a-spherical raised portion; 1211-second deposition portion; 1212-second connecting portion; 113-insulating portion; 20-device for electrochemical preparation of artificial cornea; 21-electrolyte container; 22-support seat; 221-connecting hole; 2211-first hole; 2212-second hole; 23-connecting piece; 231-insulating sleeve; 232-rubber ring; 24-fixing piece; 241-through hole. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical solution and advantages of the embodiments of the present application clearer, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, rather than all the embodiments. The components of the embodiments of the present application described and shown in the drawings here can be arranged and designed in various different configurations.

[0029] In the description of this application, it should be noted that the terms "upper", "lower", "inner", "outer", etc. indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, or the positions or positional relationships in which the product of the application is usually placed when in use. They are only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on this application. In addition, the terms "first", "second", etc. are only used to distinguish descriptions, and cannot be understood as indicating or implying relative importance.

[0030] In the description of this application, it should also be noted that, unless otherwise clearly specified and limited, the terms "set", "install", and "connect" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a direct connection, or an indirect connection through an intermediate medium, or it can be a connection between the two elements. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0031] Example

[0032] This embodiment provides an electrode assembly 10 for electrochemically preparing an artificial cornea. Figure 1-Figure 3 , which includes a cathode assembly 11 and an anode assembly 12, wherein the cathode assembly 11 includes a cathode electrode 111, and the anode assembly 12 includes an anode electrode 121, and both the anode electrode 121 and the cathode electrode 111 are conductive. The cathode electrode 111 is made of titanium, and the anode electrode 121 is made of platinum or graphite.

[0033] The cathode electrode 111 has a spherical concave portion 111a, and the anode electrode 121 has a spherical convex portion 121a. The spherical convex portion 121a and the spherical concave portion 111a are arranged in an aligned and spaced manner, and the protruding direction of the spherical convex portion 121a is the same as the concave direction of the spherical concave portion 111a. For example, in some embodiments, the spherical convex portion 121a is located above the spherical concave portion 111a, the spherical convex portion 121a protrudes in a vertically downward direction, and the spherical concave portion 111a is concave in a vertically downward direction. In addition, the spherical raised portion 121a can also be set on the left side of the spherical recessed portion 111a, the spherical raised portion 121a protrudes to the right, and the spherical recessed portion 111a is recessed to the right; the spherical raised portion 121a can also be set on the right side of the spherical recessed portion 111a, the spherical raised portion 121a protrudes to the left, and the spherical recessed portion 111a is recessed to the left.

[0034] In the electrode assembly 10 for electrochemically preparing an artificial cornea in this embodiment, the cathode electrode 111 and the anode electrode 121 are both inserted into an acidic electrolyte. The acidic electrolyte contains collagen, and the collagen is positively charged in the acidic electrolyte. The cathode electrode 111 and the anode electrode 121 are both conductive. When a current is applied to the cathode electrode 111 and the anode electrode 121 through a power source, the collagen migrates and is deposited on the cathode electrode 111 under the action of the current. Since the cathode 111 has a spherical recessed portion 111a, and the anode 121 has a spherical raised portion 121a, and the spherical raised portion 121a and the spherical recessed portion 111a are spaced apart from each other, and the raised direction of the spherical raised portion 121a is the same as the recessed direction of the spherical recessed portion 111a, the distance between the relative positions of the spherical raised portion 121a and the spherical recessed portion 111a is slightly different or consistent, and the migration distance of the collagen is slightly different or basically consistent, which can facilitate the deposition of collagen on the entire spherical recessed portion 111a.

[0035] Optionally, the curvature radius of the spherical concave portion 111a and the spherical convex portion 121a are equal, which not only allows the spherical concave portion 111a to be completely deposited with collagen, but also makes the thickness of the deposited collagen film more uniform.

[0036] Furthermore, an insulating portion 113 is provided around the edge of the spherical concave portion 111a, and the insulating portion 113 does not have a conductive property, so collagen cannot be deposited on the insulating portion 113 and the position blocked by the insulating portion 113, thereby ensuring that collagen is only deposited on the spherical concave portion 111a, and the formed artificial cornea does not need to be cut. Exemplarily, the insulating portion 113 is made of plastic or rubber, or other non-conductive materials.

[0037] Exemplarily, the cathode electrode 111 includes a first deposition portion 1111 and a first connection portion 1112 arranged around the first deposition portion 1111, the spherical concave portion 111a is arranged on the first deposition portion 1111, and the insulating portion 113 can cover the first connection portion 1112. The insulating portion 113 can be adhered to the first connection portion 1112, or can be covered on the surface of the first connection portion 1112 through other connecting members 23. In addition, the anode electrode 121 includes a second deposition portion 1211 and a second connection portion 1212 arranged around the second deposition portion 1211, and the spherical convex portion 121a is arranged on the second deposition portion 1211. The surfaces of the first connection portion 1112 and the second connection portion 1212 that are close to each other are both planes. When adjusting the distance between the spherical concave portion 111a and the spherical convex portion 121a, the first connection portion 1112 and the second connection portion 1212 are not easy to directly come close together to affect the distance adjustment between the spherical concave portion 111a and the spherical convex portion 121a.

[0038] In addition, the first deposition portion 1111 and the second deposition portion 1211 can be configured as thin sheets, and the spherical concave portion 111a is a spherical concave thin sheet, and the spherical convex portion 121a is a spherical convex thin sheet (refer to Figure 3 ), which is helpful to reduce the weight of the cathode electrode 111 and the anode electrode 121. It can be understood that the first deposition part 1111 and the second deposition part 1211 can also be set in a block shape, the depth of the spherical concave part 111a is less than the overall thickness of the cathode electrode 111, and the side of the second deposition part 1211 away from the spherical convex part 121a has no concave (refer to Figure 1 In addition, the anode electrode 121 may not be provided with the second connection portion 1212 , and the connection member 23 may be directly connected to the side of the second deposition portion 1211 away from the spherical protrusion 121 a .

[0039] In the second aspect, this embodiment provides a device 20 for electrochemically preparing an artificial cornea, please refer to Figure 4-Figure 6 , which includes the above-mentioned electrode assembly 10, an electrolyte container 21 for containing electrolyte, a support seat 22 installed on the electrolyte container 21, and the cathode electrode 111 and the anode electrode 121 are respectively connected with a connector 23, and the outer surface of the connector 23 has an insulating sleeve 231, and the insulating sleeve 231 can isolate and insulate the connector 23, so as to prevent the connector 23 corresponding to the cathode electrode 111 and the connector 23 corresponding to the anode electrode 121 from being deposited with collagen. Exemplarily, the insulating sleeve 231 is a polytetrafluoroethylene tube, which has good acid resistance, alkali resistance and corrosion resistance, and thus can have a long service life in an acidic electrolyte.

[0040] The positive electrode 121 and the negative electrode 111 are arranged at intervals in the upper and lower parts, and the connecting member 23 is slidably connected to the support seat 22 and can be raised and lowered to adjust the distance between the spherical protrusion 121a and the spherical concave part 111a. The connecting member 23 of the positive electrode 121 slides along the height direction of the support seat 22, which can drive the positive electrode 121 to rise and fall, and the connecting member 23 of the negative electrode 111 slides along the height direction of the support seat 22, which can drive the negative electrode 111 to rise and fall. By controlling the lifting amplitude of the connecting member 23 corresponding to the negative electrode 111 and the connecting member 23 corresponding to the positive electrode 121, the distance between the spherical protrusion 121a and the spherical concave part 111a can be adjusted (refer to Figure 4 and Figure 6 ).

[0041] Exemplarily, the support seat 22 has a plurality of connection holes 221 along its thickness direction, and the connector 23 is sleeved with a rubber ring 232. The rubber ring 232 is elastic, and when the inner diameter is expanded, the rubber ring 232 can move along the length direction of the connector 23. When the rubber ring 232 returns to its original state, it can be fixed on the outer surface of the connector 23. The connector 23 can be inserted into the connection hole 221, and the rubber ring 232 can abut against the connection hole 221 to limit the lifting of the connector 23. When it is necessary to control the lifting degree of the connector 23, the rubber ring 232 is moved to a suitable position of the connector 23, and the rubber ring 232 is kept fixed on the outer surface of the connector 23, and then the connector 23 is passed through the connection hole 221, and the rubber ring 232 abuts in the connection hole 221, so as to adjust the spherical concave portion 111a and the spherical convex portion 121a to a suitable position.

[0042] Furthermore, the connection hole 221 includes a first hole 2211 and a second hole 2212 coaxially arranged, and the aperture of the first hole 2211 is larger than the aperture of the second hole 2212, and the first hole 2211 and the second hole 2212 form a step, and the connection member 23 can be inserted into the first hole 2211 and the second hole 2212, and the rubber ring 232 can move in the first hole 2211 and abut on the step. The connection member 23 is inserted into the second hole 2212 and extends to the first hole 2211, and the outer diameter of the rubber ring 232 is larger than the inner diameter of the second hole 2212 and smaller than the inner diameter of the first hole 2211, and the rubber ring 232 can abut on the step formed by the first hole 2211 and the second hole 2212, so as to fix the anode electrode 121 and the cathode electrode 111 at a suitable height.

[0043] In addition, the device 20 for preparing an artificial cornea by electrochemical means in this embodiment further comprises a fixing member 24, the inner wall of the first hole 2211 has an inner thread, the outer wall of the fixing member 24 has an outer thread matching the inner thread of the first hole 2211, and a through hole 241 is provided along the height direction of the fixing member 24, the fixing member 24 can be threadedly connected with the first hole 2211, and the bottom end of the fixing member 24 can be pressed on the rubber ring 232. By sleeved the fixing member 24 on the connecting member 23, the connecting member 23 passes through the through hole 241 of the fixing member 24, and the fixing member 24 is threadedly connected with the first hole 2211 and the rubber ring 232 is pressed on the step formed by the first hole 2211 and the second hole 2212, the connecting member 23 is relatively fixed and restricted from moving up and down and rotating.

[0044] In summary, in the electrode assembly 10 for preparing an artificial cornea by electrochemical method in the embodiment of the present application, the cathode electrode 111 and the anode electrode 121 are both conductive, and current is applied to the cathode electrode 111 and the anode electrode 121 by a power supply, so that collagen can be deposited on the cathode electrode 111. Since the cathode electrode 111 has a spherical concave portion 111a, and the anode electrode 121 has a spherical convex portion 121a, and the spherical convex portion 121a and the spherical concave portion 111a are arranged in an aligned and spaced manner, and the convex direction of the spherical convex portion 121a is the same as the concave direction of the spherical concave portion 111a, the distance between the relative positions of the spherical convex portion 121a and the spherical concave portion 111a is small or consistent, and the entire area of ​​the spherical concave portion 111a of the cathode electrode 111 can be deposited with collagen, so that an artificial cornea can be effectively prepared.

[0045] The device 20 for electrochemically preparing an artificial cornea according to the embodiment of the present application can adjust the distance between the spherical protrusion 121a and the spherical recessed portion 111a by controlling the raising and lowering amplitudes of the connecting member 23 corresponding to the cathode electrode 111 and the connecting member 23 corresponding to the anode electrode 121.

[0046] The above are only preferred embodiments of the present application and are not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. An electrode assembly for electrochemically preparing an artificial cornea, characterized in that: include: a cathode assembly, the cathode assembly comprising a cathode electrode, the cathode electrode having a spherical concave portion; as well as An anode assembly, the anode assembly comprising an anode electrode, the anode electrode having a spherical protrusion, and the spherical protrusion and the spherical concave portion are arranged in alignment and at intervals, the protruding direction of the spherical protrusion is the same as the concave direction of the spherical concave portion, and both the anode electrode and the cathode electrode are capable of conducting electricity.

2. The electrode assembly for electrochemically preparing an artificial cornea according to claim 1, characterized in that: The curvature radii of the spherical concave portion and the spherical convex portion are equal.

3. The electrode assembly for electrochemically preparing an artificial cornea according to claim 1, characterized in that: An insulating portion is also arranged around the edge of the spherical recessed portion.

4. The electrode assembly for electrochemically preparing an artificial cornea according to claim 3, characterized in that: The cathode electrode includes a first deposition portion and a first connection portion arranged around the first deposition portion, the spherical concave portion is arranged in the first deposition portion, and the insulating portion can cover the first connection portion.

5. The electrode assembly for electrochemically preparing an artificial cornea according to claim 4, characterized in that: The anode electrode includes a second deposition portion and a second connection portion arranged around the second deposition portion, and the spherical protrusion is arranged on the second deposition portion.

6. The electrode assembly for electrochemically preparing an artificial cornea according to any one of claims 1 to 5, characterized in that: The cathode electrode is made of titanium, and the anode electrode is made of platinum or graphite.

7. A device for electrochemically preparing an artificial cornea, characterized in that: The invention comprises an electrode assembly for electrochemically preparing an artificial cornea as claimed in any one of claims 1 to 6, an electrolyte container for containing electrolyte and a support seat mounted on the electrolyte container, wherein the cathode electrode and the anode electrode are respectively connected with connectors, and the outer surfaces of the connectors have insulating sleeves; the connectors are slidably connected to the support seat and can be raised and lowered to adjust the distance between the spherical protrusion and the spherical recess.

8. The device for electrochemically preparing an artificial cornea according to claim 7, characterized in that: The support seat has a plurality of connection holes along its thickness direction, and the connection piece is sleeved with a rubber ring, which can move along the length direction of the connection piece and be fixed to the outer surface of the connection piece; the connection piece can be inserted into the connection hole, and the rubber ring can abut against the connection hole to limit the lifting and lowering of the connection piece.

9. The device for electrochemically preparing an artificial cornea according to claim 8, characterized in that: The connecting hole includes a first hole and a second hole which are coaxially arranged, and the aperture of the first hole is larger than the aperture of the second hole. The first hole and the second hole form a step. The connecting member can be inserted into the first hole and the second hole. The rubber ring can move in the first hole and abut against the step.

10. The device for electrochemically preparing an artificial cornea according to claim 9, characterized in that: It also includes a fixing piece, the inner wall of the first hole has an internal thread, the outer wall of the fixing piece has an external thread matching the internal thread of the first hole, and a through hole is provided along the height direction of the fixing piece, the connecting piece can be inserted into the through hole, the fixing piece can be threadedly connected to the first hole, and the bottom end of the fixing piece can be pressed on the rubber ring.

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