Mass spectrum calibration device and mass spectrum detection system

Abstract

The embodiment of the utility model provides a mass spectrum calibration device and a mass spectrum detection system.The mass spectrum calibration device comprises a containing part, a containing cavity is formed in the containing part, a leakage hole is formed in the containing part, an inlet of the leakage hole is communicated with the containing cavity, and an outlet of the leakage hole is located at the connecting end of the containing part; the accommodating cavity is used for accommodating electrolyte; one end of the pipeline assembly is connected to the connecting end of the containing part, and the other end of the pipeline assembly is used for being connected to a mass spectrometer, so that the stability of the electrolyte sample injection amount is guaranteed, and the calibration accuracy of the mass spectrum calibration device is improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of mass spectrometry, and specifically relates to a mass spectrometry calibration device and a mass spectrometry detection system. Background Art

[0002] When calibrating a current mass spectrometer, a standard leak filled with electrolyte needs to be placed in a closed chamber, and the test calibration can be performed only after the closed chamber reaches a certain vacuum degree.

[0003] However, since the space of the closed chamber is large, the vacuum pumping time is long, and the volatilization of the electrolyte in the closed chamber easily causes the problem of undetectable electrolyte, which reduces the stability of electrolyte injection and affects the accuracy of mass spectrometry calibration. Utility Model Content

[0004] One purpose of the utility model is to provide a new technical solution for a mass spectrometer calibration device and a mass spectrometer detection system.

[0005] According to a first aspect of the utility model, a mass spectrometer calibration device is provided, comprising:

[0006] A container, wherein the container has a housing cavity inside, a leakage hole is provided on the container, an inlet of the leakage hole is connected to the housing cavity, an outlet of the leakage hole is located at a connection end of the container, and the housing cavity is used to contain electrolyte;

[0007] A pipeline assembly, one end of which is connected to the connecting end of the container, and the other end of which is used to connect to the mass spectrometer.

[0008] Optionally, the accommodating component includes a base and a plug, the leakage hole is arranged on the base, one end of the base forms the connecting end, the other end of the base forms an open end, the plug is connected to the open end of the base and forms the accommodating cavity between the plug and the base.

[0009] Optionally, the plug includes a plug cap and an annular connecting portion, the annular connecting portion is plug-fitted with the open end of the base, and the plug cap abuts against the open end of the base.

[0010] Optionally, the leakage hole has a pore size ranging from 100 to 150 μm.

[0011] Optionally, the pipeline assembly includes a sampling tube, one end of which is connected to the connecting end of the base, and the other end of which is used to be connected to a mass spectrometer.

[0012] Optionally, a sealing ring is further included, and the sealing ring is clamped between one end of the sampling tube and the connecting end of the base.

[0013] Optionally, one end of the sampling tube has a first flange, the connecting end of the base has a second flange, and the sealing ring is sandwiched between the first flange and the second flange.

[0014] Optionally, a clamp is further included, and the clamp is sleeved on the outer circumference of the first flange and the second flange.

[0015] According to a second aspect of the utility model, a mass spectrometry detection system is provided, comprising a mass spectrometer and the mass spectrometry calibration device described in the first aspect;

[0016] The other end of the pipeline assembly is connected to the mass spectrometer.

[0017] Optionally, a vacuum pump is further included, which is connected to the pipeline assembly and is used to evacuate the containing chamber.

[0018] A technical effect of the utility model is:

[0019] An embodiment of the present application provides a mass spectrometer calibration device, which includes a accommodating component, wherein the accommodating component has a accommodating cavity inside, and a leakage hole is provided on the accommodating component, the inlet of the leakage hole is connected to the accommodating cavity, and the outlet of the leakage hole is located at the connecting end of the accommodating component, and the accommodating cavity is used to accommodate an electrolyte; a pipeline assembly, one end of the pipeline assembly is connected to the connecting end of the accommodating component, and the other end of the pipeline assembly is used to be connected to a mass spectrometer, thereby ensuring the stability of the electrolyte injection amount and improving the calibration accuracy of the mass spectrometer calibration device.

[0020] Other features and advantages of the present invention will become apparent from the following detailed description of exemplary embodiments of the present invention with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate embodiments of the present invention and, together with the description, serve to explain the principles of the present invention.

[0022] Figure 1 A cross-sectional view of a base of a mass spectrometer calibration device provided by one embodiment of the utility model;

[0023] Figure 2 for Figure 1 The enlarged view of point A in the middle;

[0024] Figure 3 A cross-sectional view of a container of a mass spectrometer calibration device provided by one embodiment of the utility model;

[0025] Figure 4 A schematic diagram of a mass spectrometer calibration device provided in one embodiment of the utility model;

[0026] Figure 5 An exploded view of a mass spectrometer calibration device provided in one embodiment of the utility model;

[0027] Figure 6 A schematic diagram of a mass spectrometry detection system provided for one embodiment of the utility model.

[0028] in:

[0029] 100. mass spectrometer calibration device; 1. receiving member; 11. leakage hole; 12. base; 121. second flange; 13. plug; 131. plug cap; 132. annular connecting portion; 2. pipeline assembly; 21. sampling tube; 211. first flange; 3. sealing ring; 4. clamp;

[0030] 200. Mass spectrometer; 300. Vacuum pump. DETAILED DESCRIPTION

[0031] Various exemplary embodiments of the present invention will now be described in detail with reference to the accompanying drawings. It should be noted that unless otherwise specifically stated, the relative arrangements of components and steps, numerical expressions and numerical values ​​set forth in these embodiments do not limit the scope of the present invention.

[0032] The embodiments of the present application will be described in detail below, and examples of the embodiments are shown in the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present application, and should not be understood as limiting the present application. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in the field without making creative work are within the scope of protection of the present application.

[0033] The term "first" or "second" in the specification and claims of this application may include one or more of the features explicitly or implicitly. In the description of this application, unless otherwise specified, "plurality" means two or more. In addition, "and / or" in the specification and claims means at least one of the connected objects, and the character " / " generally means that the objects connected before and after are in an "or" relationship.

[0034] In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0035] In the description of this application, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to specific circumstances.

[0036] It should be noted that like reference numerals and letters refer to similar items in the following figures, and therefore, once an item is defined in one figure, it need not be further discussed in subsequent figures.

[0037] Reference Figures 1 to 4 , an embodiment of the present application provides a mass spectrometer calibration device, the mass spectrometer calibration device comprising:

[0038] A container 1, wherein the container 1 has a housing cavity therein, a leakage hole 11 is provided on the container 1, an inlet of the leakage hole 11 is connected to the housing cavity, an outlet of the leakage hole 11 is located at a connection end of the container 1, and the housing cavity is used to contain electrolyte;

[0039] A pipeline assembly 2, one end of which is connected to the connection end of the container 1, and the other end of which is used to connect to a mass spectrometer.

[0040] In this embodiment, the accommodating cavity of the accommodating component 1 is used to accommodate electrolyte; when the mass spectrometer calibration device is calibrated, since one end of the pipe assembly 2 is connected to the connecting end of the accommodating component 1, and the other end of the pipe assembly 2 is used to connect to the mass spectrometer, the electrolyte in the accommodating cavity can be output from the connecting end of the accommodating component 1 through the leakage hole 11 under vacuum conditions, and the output electrolyte is then transported to the mass spectrometer through the pipe assembly 2 for mass spectrometer calibration.

[0041] The space outside the container 1 will affect the quantitative calibration of the mass spectrometer calibration device, and the pipeline assembly 2 of the embodiment of the present application is directly connected to the connecting end of the container 1, which can prevent the electrolyte in the accommodating cavity from volatilizing to the space outside the container 1, thereby ensuring the stability of the electrolyte injection amount, making the calibration process of the mass spectrometer calibration device more convenient and capable of quantitative calibration, thereby improving the calibration accuracy of the mass spectrometer calibration device.

[0042] The mass spectrometer calibration device provided in the embodiment of the present application allows the electrolyte to be transported only in the container 1 and the pipeline assembly 2, and can distinguish the values ​​of smaller electrolyte amounts, thereby ensuring the calibration sensitivity of the mass spectrometer calibration device.

[0043] The mass spectrometer calibration device provided in the embodiment of the present application includes a container 1, wherein the container 1 has a accommodating cavity inside, and a leakage hole 11 is provided on the container 1, wherein the inlet of the leakage hole 11 is connected to the accommodating cavity, and the outlet of the leakage hole 11 is located at the connecting end of the container 1, and the accommodating cavity is used to accommodate an electrolyte; a pipeline assembly 2, wherein one end of the pipeline assembly 2 is connected to the connecting end of the container 1, and the other end of the pipeline assembly 2 is used to be connected to a mass spectrometer, thereby ensuring the stability of the electrolyte injection amount and improving the calibration accuracy of the mass spectrometer calibration device.

[0044] In one embodiment, see Figure 3 The accommodating component 1 includes a base 12 and a plug 13, the leakage hole 11 is arranged on the base 12, one end of the base 12 forms the connecting end, the other end of the base 12 forms an opening end, and the plug 13 is connected to the opening end of the base 12 and forms the accommodating cavity with the base 12.

[0045] In this embodiment, the open end of the base 12 may have a groove, the leakage hole 11 is connected to the groove, and the internal space of the groove forms at least a partial accommodating cavity; the plug 13 is connected to the groove and seals the opening of the groove to form the accommodating cavity between the plug 13 and the base 12, thereby ensuring the sealing of the accommodating cavity.

[0046] In one embodiment, see Figure 3 The plug 13 includes a plug cap 131 and an annular connecting portion 132 . The annular connecting portion 132 is plugged into and matched with the open end of the base 12 , and the plug cap 131 abuts against the open end of the base 12 .

[0047] In this embodiment, a groove is provided at the open end of the base 12, and the groove has an opening away from the connection end of the base 12. The annular connecting portion 132 can be plugged into the groove through the opening of the groove to form the accommodating cavity between the plug 13 and the base 12; and the plug cap 131 abuts against the side wall of the groove to prevent leakage of the electrolyte in the accommodating cavity.

[0048] In one embodiment, see Figure 1 and Figure 2 The pore size of the leakage hole 11 is in the range of 100-150 μm.

[0049] In this embodiment, by controlling the aperture of the leakage hole 11 within the range of 100-150 μm, it is possible to avoid volatilization of the electrolyte in the accommodating chamber when no calibration is performed, and to ensure that the electrolyte in the accommodating chamber is sampled through the leakage hole 11. In a specific embodiment, the aperture of the leakage hole 11 is 120 μm, so as to form a capillary structure of the leakage hole 11 as a leakage channel, thereby ensuring the effectiveness of the electrolyte sampled through the leakage hole 11.

[0050] In one embodiment, see Figure 4 and Figure 5 The pipeline assembly 2 includes a sampling tube 21, one end of the sampling tube 21 is connected to the connecting end of the base 12, and the other end of the sampling tube 21 is used to connect to the mass spectrometer.

[0051] In this embodiment, one end of the sampling tube 21 can be plugged or screwed with the connecting end of the base 12 to facilitate installation and removal of the sampling tube 21 and the base 12. In addition, the accommodating part 1 is directly connected to the sampling tube 21, which can eliminate the influence of the external space of the accommodating part 1 on the electrolyte injection amount, avoid the problem of excessive electrolyte gasification caused by the long vacuum time of the external space of the accommodating part 1, and ensure the stability of the electrolyte injection amount in the accommodating cavity.

[0052] In one embodiment, see Figure 5 The mass spectrometer calibration device also includes a sealing ring 3 , which is clamped between one end of the sampling tube 21 and the connecting end of the base 12 .

[0053] In this embodiment, the electrolyte in the accommodating cavity can be output from the connecting end of the accommodating component 1 through the leakage hole 11, and the output electrolyte is further transported to the mass spectrometer through the pipeline assembly 2. The sealing ring 3 is clamped between one end of the sampling tube 21 and the connecting end of the base 12, thereby ensuring the airtightness of the connection between the accommodating component 1 and the sampling tube 21.

[0054] In one embodiment, see Figure 5One end of the sampling tube 21 has a first flange 211 , the connecting end of the base 12 has a second flange 121 , and the sealing ring 3 is sandwiched between the first flange 211 and the second flange 121 .

[0055] In this embodiment, the first flange 211 is located at one end of the sampling tube 21 close to the base 12, and the second flange 121 is located at one end of the base 12 close to the sampling tube 21. The first flange 211 and the second flange 121 are arranged relative to each other, which can provide a larger clamping surface for the sealing ring 3, thereby ensuring the stability of the first flange 211 and the second flange 121 in clamping the sealing ring 3.

[0056] In one embodiment, the first flange 211 has a first annular groove on the side facing the second flange 121, and the second flange 121 has a second annular groove on the side facing the first flange 211. A portion of the sealing ring 3 is embedded in the first annular groove, and another portion of the sealing ring 3 is embedded in the second annular groove to avoid displacement of the sealing ring 3 and ensure the accuracy of the setting position of the sealing ring 3.

[0057] In one embodiment, see Figure 5 The mass spectrometer calibration device further includes a clamp 4 , which is sleeved on the outer periphery of the first flange 211 and the second flange 121 .

[0058] In this embodiment, when the first flange 211 and the second flange 121 are arranged relative to each other, the outer edges of the first flange 211 and the second flange 121 protrude outward, which can facilitate the clamp 4 to be sleeved on the outer edges of the first flange 211 and the second flange 121, thereby connecting the accommodating part 1 and the sampling tube 21, thereby ensuring the firmness of the connection between the accommodating part 1 and the sampling tube 21.

[0059] In one embodiment, the calibration process of the mass spectrometer calibration device provided in the embodiment of the present application includes:

[0060] S101, dripping 5 μL of electrolyte into the receiving cavity of the receiving component;

[0061] S102, connecting the receiving component and one end of the sampling tube together with a clamp, and sandwiching a sealing ring between the receiving component and the sampling tube, and connecting the other end of the sampling tube to a mass spectrometer;

[0062] S103, start the mass spectrometer to perform automatic calibration and output the calibration result.

[0063] See also Figure 6 , the embodiment of the present application further provides a mass spectrometry detection system, the mass spectrometry detection system comprising a mass spectrometer 200 and the mass spectrometry calibration device 100;

[0064] The other end of the pipeline assembly 2 is connected to the mass spectrometer 200 .

[0065] In this embodiment, the mass spectrometer calibration device 100 of the mass spectrometer detection system includes a container 1, the container 1 has a accommodating cavity inside, the container 1 is provided with a leakage hole 11, the inlet of the leakage hole 11 is connected to the accommodating cavity, the outlet of the leakage hole 11 is located at the connecting end of the container 1, and the accommodating cavity is used to accommodate electrolyte; a pipeline assembly 2, one end of the pipeline assembly 2 is connected to the connecting end of the container 1, and the other end of the pipeline assembly 2 is used to be connected to a mass spectrometer, thereby ensuring the stability of the electrolyte injection amount and improving the calibration accuracy of the mass spectrometer detection system.

[0066] In one embodiment, see Figure 6 The mass spectrometry detection system further includes a vacuum pump 300, which is connected to the pipeline assembly 2 and is used to evacuate the containing chamber.

[0067] In this embodiment, the electrolyte in the accommodating chamber can be output from the connecting end of the accommodating component 1 through the leakage hole 11 under the condition of vacuum, and the output electrolyte is then transported to the mass spectrometer through the pipeline assembly 2; and the vacuum pump 300 is connected to the pipeline assembly 2 and is used to evacuate the accommodating chamber, so as to facilitate the output of the electrolyte in the accommodating chamber through the leakage hole 11, thereby improving the efficiency of the mass spectrometer calibration of the mass spectrometer detection system.

[0068] Although some specific embodiments of the present invention have been described in detail by way of examples, it should be understood by those skilled in the art that the above examples are for illustration only and are not intended to limit the scope of the present invention. It should be understood by those skilled in the art that the above embodiments may be modified without departing from the scope and spirit of the present invention. The scope of the present invention is defined by the appended claims.

Claims

1. A mass spectrometer calibration device, characterized in that: include: A container (1), wherein the container (1) has a container cavity inside, a leakage hole (11) is provided on the container (1), an inlet of the leakage hole (11) is connected to the container cavity, an outlet of the leakage hole (11) is located at a connection end of the container (1), and the container cavity is used to contain electrolyte; A pipeline assembly (2), one end of which is connected to the connection end of the container (1), and the other end of which is used to be connected to a mass spectrometer.

2. The mass spectrometer calibration device according to claim 1, characterized in that: The accommodating member (1) comprises a base (12) and a plug (13); the leakage hole (11) is arranged on the base (12); one end of the base (12) forms the connecting end; the other end of the base (12) forms the opening end; the plug (13) is connected to the opening end of the base (12) and forms the accommodating cavity with the base (12).

3. The mass spectrometer calibration device according to claim 2, characterized in that: The plug (13) comprises a plugging cap (131) and an annular connecting portion (132); the annular connecting portion (132) is plug-fitted with the open end of the base (12); and the plugging cap (131) abuts against the open end of the base (12).

4. The mass spectrometer calibration device according to claim 1, characterized in that: The pore size of the leakage hole (11) is in the range of 100-150 μm.

5. The mass spectrometer calibration device according to claim 2, characterized in that: The pipeline assembly (2) comprises a sampling tube (21), one end of the sampling tube (21) is connected to the connecting end of the base (12), and the other end of the sampling tube (21) is used to be connected to a mass spectrometer.

6. The mass spectrometer calibration device according to claim 5, characterized in that: It also comprises a sealing ring (3), wherein the sealing ring (3) is sandwiched between one end of the sampling tube (21) and the connecting end of the base (12).

7. The mass spectrometer calibration device according to claim 6, characterized in that: One end of the sampling tube (21) has a first flange (211), the connecting end of the base (12) has a second flange (121), and the sealing ring (3) is sandwiched between the first flange (211) and the second flange (121).

8. The mass spectrometer calibration device according to claim 7, characterized in that: It also comprises a clamp (4), wherein the clamp (4) is sleeved on the outer circumference of the first flange (211) and the second flange (121).

9. A mass spectrometry detection system, characterized in that: Comprising a mass spectrometer (200) and a mass spectrometer calibration device (100) according to any one of claims 1 to 8; The other end of the pipeline assembly (2) is connected to the mass spectrometer (200).

10. The mass spectrometry detection system according to claim 9, characterized in that: It also includes a vacuum pump (300), which is connected to the pipeline assembly (2) and is used to evacuate the containing chamber.

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