Production reaction device for medical intermediates

Abstract

The utility model provides a production reaction device for medical intermediates, which relates to the technical field of medical intermediates and comprises a reaction kettle, the outer top of the reaction kettle is communicated and connected with a feed pipe, and the outer bottom of the reaction kettle is communicated and connected with a discharge pipe. And crushing mechanisms for scattering and dredging various reaction materials are arranged in the feeding pipe and the discharging pipe. When various reaction materials are conveyed and discharged out of the reaction kettle, the crushing blades and the rotating blades are driven to rotate by rotating the driving rod, so that the various reaction materials can be crushed and scattered, the various reaction materials are prevented from being blocked in the feeding pipe and the discharging pipe, and the working efficiency of processing production is further improved; and meanwhile, the working step of cleaning the interior of the feeding and discharging pipe is avoided, and the production cost is reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceutical intermediates, in particular to a production reaction device for pharmaceutical intermediates. Background Art

[0002] Pharmaceutical intermediates are actually some chemical raw materials or chemical products used in the process of drug synthesis. Such chemical products do not require a drug production license and can be produced in ordinary chemical plants. As long as they reach a certain level, they can be used in the synthesis of drugs. When processing pharmaceutical intermediates, various reaction materials will be added to mix evenly and react with each other, and some of them need to be crushed to avoid clogging the pipeline, thereby affecting the processing effect.

[0003] At present, most general reaction devices use long-axis paddle stirring, which drives the paddle to rotate circumferentially around the long axis to stir by rotating the long axis. For example, Chinese Patent Publication No. CN218590540U discloses a reactor for the production of pharmaceutical intermediates, including a reactor body, a through hole, a discharge pipe and a stirring rod, and a driving component for driving the filter plate to move is provided in the discharge pipe. The above-mentioned public document can obtain a purer reaction product from the reactor, thereby reducing the work intensity of the staff. However, when the patent is in use, when the reactor is inputting and discharging the reaction materials, some materials will easily clog the inside of the inlet and outlet pipes, and then the inside of the inlet and outlet pipes needs to be cleaned, which increases unnecessary labor and leads to reduced processing efficiency. To this end, a person skilled in the art provides a production reaction device for pharmaceutical intermediates to solve the problems raised in the above-mentioned background technology. Utility Model Content

[0004] In view of the deficiencies in the prior art, the utility model provides a production reaction device for pharmaceutical intermediates, which can effectively solve the problem in the background technology that when the reactor is inputting and discharging reaction materials, some materials will easily be blocked inside the inlet and outlet pipes, and then the inside of the inlet and outlet pipes needs to be cleaned, which increases unnecessary labor and thus reduces processing efficiency.

[0005] To achieve the above objectives, the utility model is implemented through the following technical solutions: a production reaction device for pharmaceutical intermediates, comprising a reactor, the outer top of the reactor is connected with a feed pipe, and the outer bottom of the reactor is connected with a discharge pipe, and the feed pipe and the discharge pipe are provided with a crushing mechanism for breaking up and clearing various reaction materials;

[0006] The reactor is provided with a mixing mechanism for uniformly stirring various reaction materials;

[0007] The outer side wall of the reactor is connected with a supporting assembly via a jacket.

[0008] As a further technical solution of the utility model, the crushing mechanism includes fixed circular plates respectively arranged on the inner side walls of the feed pipe and the discharge pipe, and the outer tops of the two fixed circular plates are provided with through-type arc grooves at equal intervals around the center of the circle. A driving rod is rotatably connected inside the feed pipe and the discharge pipe and located on the outer tops of the fixed circular plates. The outer surfaces of the two driving rods are respectively provided with crushing slices and rotating blades along their side walls and located at the upper and lower ends of the fixed circular plates. One end of one of the driving rods extends to the outside of the feed pipe, and a first gear is installed on its outer surface.

[0009] As a further technical solution of the utility model, the mixing mechanism includes a rotating rod rotatably connected to the inside of the reactor, one end of the rotating rod extends to the outer top of the reactor, and a second gear is installed on its outer surface, the other end of the driving rod is fixedly connected to the driving rod on the discharge pipe, and stirring blades are connected to the inside of the reactor and outside the rotating rod at equal intervals along its side wall, and an L-shaped scraper is also connected to the bottom end, and a driving motor is installed at the outer top of the reactor and corresponding to the rotating rod, the output end of the driving motor is connected to the driving rod, and the second gear is meshingly connected to the first gear.

[0010] As a further technical solution of the utility model, the support assembly includes a limiting ring installed outside the reactor and located on the bottom of the outer wall of the jacket, the outer bottom of the limiting ring is evenly spaced with fixed columns, and the outer bottoms of the four fixed columns are connected to pads.

[0011] As a further technical solution of the utility model, a conveying square tube is obliquely inserted into the outer wall of the feed pipe, and a sealing cover is connected to the end of the discharge pipe.

[0012] As a further technical solution of the utility model, the outer side walls on both sides of the jacket are respectively connected with an air inlet pipe and an air outlet pipe.

[0013] The utility model provides a production reaction device for pharmaceutical intermediates, which has the following beneficial effects compared with the prior art:

[0014] 1. A production reaction device for pharmaceutical intermediates. When various reaction materials are transported and discharged from a reactor, the crushing slices and rotating blades are driven to rotate by rotating a driving rod, so that various reaction materials can be crushed and dispersed to prevent various reaction materials from being blocked in a feed pipe and a discharge pipe, thereby helping to improve the work efficiency of processing and production, while avoiding the work step of cleaning the inside of the feed and discharge pipes, and reducing production costs.

[0015] 2. A production reaction device for pharmaceutical intermediates uses a driving motor as a power source to drive a rotating rod to rotate, thereby driving a stirring blade to continuously flip various reaction materials to make them evenly mixed. At the same time, under the meshing characteristics of the gears, the second gear drives the first gear to rotate, and then the driving rod is synchronously driven to rotate when the rotating rod rotates. The operation is convenient. Secondly, hot air is injected into the jacket to continuously heat the reactor to promote rapid reaction of various reaction materials, thereby further improving the applicability of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a schematic diagram of the three-dimensional structure of a production reaction device for a pharmaceutical intermediate;

[0017] Figure 2 It is a schematic diagram of the cross-sectional three-dimensional structure of a production reaction device for a pharmaceutical intermediate;

[0018] Figure 3 for Figure 2 A partial enlarged view of point A in the middle.

[0019] In the figure: 1. Reactor; 2. Limiting ring; 3. Fixed column; 4. Feed pipe; 5. Discharge pipe; 6. Conveying square pipe; 7. Jacket; 8. Fixed circular plate; 9. Driving motor; 10. First gear; 11. Second gear; 12. Arc notch; 13. Driving rod; 14. Rotating rod; 15. Crushing and slicing; 16. Rotating blade; 17. Stirring blade; 18. L-shaped scraper; 19. Sealing cover. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, rather than all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the utility model.

[0021] See also Figure 1-3As shown, a production reaction device for pharmaceutical intermediates includes a reactor 1, a feed pipe 4 is connected through the outer top of the reactor 1, and a discharge pipe 5 is connected through the outer bottom of the reactor 1, and a crushing mechanism for breaking up and clearing various reaction materials is arranged inside the feed pipe 4 and the discharge pipe 5, and the crushing mechanism includes fixed circular plates 8 respectively arranged on the inner side walls of the feed pipe 4 and the discharge pipe 5, and through-type arc notches 12 are opened on the outer tops of the two fixed circular plates 8 at equal intervals around the center of the circle, and a driving rod 13 is rotatably connected inside the feed pipe 4 and the discharge pipe 5 and located on the outer top of the fixed circular plate 8, and the outer surfaces of the two driving rods 13 are respectively installed with crushing slices 15 and rotating blades 16 along the side walls thereof and located at the upper and lower ends of the fixed circular plate 8, one end of one of the driving rods 13 extends to the outside of the feed pipe 4, and a first gear 10 is installed on its outer surface. By rotating the first gear 10 to drive the driving rod 13 to rotate, and then drive the crushing slice 15 and the rotating blade 16 to rotate, some reaction materials are crushed and dispersed to prevent the reaction materials from causing blockage, thereby increasing unnecessary cleaning workload.

[0022] The interior of the reactor 1 is provided with a mixing mechanism for uniformly stirring various reaction materials, and the mixing mechanism includes a rotating rod 14 rotatably connected to the interior of the reactor 1, one end of the rotating rod 14 extends to the outer top of the reactor 1, and a second gear 11 is installed on its outer surface, and the other end of the driving rod 13 is fixedly connected to the driving rod 13 on the discharge pipe 5, and the interior of the reactor 1 and the outside of the rotating rod 14 and along its side wall are connected with stirring blades 17 at equal intervals, and an L-shaped scraper 18 is also connected to its bottom end, and a driving motor 9 is installed at the outer top of the reactor 1 and corresponding to the rotating rod 14, the output end of the driving motor 9 is connected to the driving rod 13, the second gear 11 is meshingly connected to the first gear 10, and the outer side walls on both sides of the jacket 7 are respectively connected with an air inlet pipe and an air outlet pipe. By starting the driving motor 9, the rotating rod 14 is driven to rotate, and then the stirring blade 17 is driven to continuously flip and stir the reaction materials, so that they are stored and mixed evenly, and the L-shaped scraper 18 is used to scrape and stir the reaction materials on the inner side wall and the inner bottom surface of the reactor 1 during rotation, so that they are fully mixed. At the same time, under the meshing characteristics of the gears, the second gear 11 drives the first gear 10 to rotate, and then the driving rod 13 is synchronously driven to rotate when the rotating rod 14 rotates, which is convenient to operate. At the same time, hot air is continuously injected into the jacket 7 through the air inlet pipe and discharged through the air outlet pipe, so that the reactor 1 is continuously heated to promote the rapid reaction of various reaction materials, thereby further improving the applicability of the device.

[0023] The support assembly includes a limiting ring 2 installed outside the reactor 1 and located on the bottom of the outer wall of the jacket 7. The outer bottom of the limiting ring 2 is connected with fixed columns 3 at equal intervals, and the outer bottoms of the four fixed columns 3 are connected with pads. Through the cooperation between the limiting ring 2, the fixed columns 3 and the pad, the reactor 1 is provided with a limiting and fixed support function.

[0024] A conveying square tube 6 is obliquely inserted on the outer side wall of the feed pipe 4, and a sealing cap 19 is connected to the end of the discharge pipe 5. The conveying square tube 6 is convenient for conveying materials, and the pharmaceutical intermediate that has been reacted can be taken out by twisting the sealing cap 19.

[0025] The working principle of the utility model is as follows: when carrying out a production reaction, various reaction materials are first placed in the feed pipe 4 along the conveying square tube 6 in sequence, and then the driving motor 9 is started to drive the second gear 11 on the rotating rod 14 to drive the first gear 10 to rotate under the meshing characteristics, so that the crushing slices 15 and the rotating blades 16 on the driving rod 13 rotate in the feed pipe 4, and then the various reaction materials are crushed and dispersed, so as to avoid the various reaction materials from clogging the feed pipe 4 when being added, which not only leads to a poor effect of the processing and production reaction, but also requires manual cleaning when clogging occurs, which is time-consuming and labor-intensive.

[0026] After the various reaction materials are crushed and dispersed, they enter the reactor 1 and are constantly turned and stirred by the stirring blades 17 and the scraper on the rotating rod 14 to make them evenly mixed. At the same time, the hot air is transported to the jacket 7 along the air inlet pipe and discharged through the air outlet pipe, thereby heating the reactor 1 to improve the reaction efficiency during the mixing reaction.

[0027] Secondly, when the rotating rod 14 rotates, it drives the crushing slices 15 and the rotating blades 16 on one of the driving rods 13 to rotate in the discharge pipe 5, and then the various reaction materials are crushed and dispersed again, so that they can be discharged smoothly, and then the sealing cover 19 is opened to discharge them.

[0028] The above is only a preferred embodiment of the present invention. It should be noted that, for ordinary technicians in the technical field, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be regarded as the protection scope of the present invention. The structures, devices and operating methods not specifically described and explained in the present invention shall be implemented according to the conventional means in the field unless otherwise specified and limited.

Claims

1. A production reaction device for pharmaceutical intermediates, characterized in that: The invention comprises a reaction kettle (1), wherein a feed pipe (4) is connected through the top of the reaction kettle (1), and a discharge pipe (5) is connected through the bottom of the reaction kettle (1), and a crushing mechanism for breaking up and clearing various reaction materials is arranged inside the feed pipe (4) and the discharge pipe (5); The reactor (1) is provided with a mixing mechanism for uniformly stirring various reaction materials; The outer wall of the reaction kettle (1) is connected to a support assembly via a jacket (7); The crushing mechanism comprises fixed circular plates (8) respectively arranged on the inner side walls of the feed pipe (4) and the discharge pipe (5); the outer tops of the two fixed circular plates (8) are provided with through-type arc slots (12) at equal intervals around the center of the circle; a driving rod (13) is rotatably connected inside the feed pipe (4) and the discharge pipe (5) and located on the outer tops of the fixed circular plates (8); crushing slices (15) and rotating blades (16) are respectively installed on the outer surfaces of the two driving rods (13) along their side walls and located at the upper and lower ends of the fixed circular plates (8); one end of one of the driving rods (13) extends to the outside of the feed pipe (4), and a first gear (10) is installed on its outer surface.

2. The production reaction device of a pharmaceutical intermediate according to claim 1, characterized in that: The mixing mechanism comprises a rotating rod (14) rotatably connected to the inside of the reactor (1), one end of the rotating rod (14) extends to the outer top of the reactor (1), and a second gear (11) is installed on the outer surface of the rotating rod, the other end of the driving rod (13) is fixedly connected to the driving rod (13) on the discharge pipe (5), the inside of the reactor (1) and outside the rotating rod (14) and along the side wall thereof are connected with stirring blades (17) at equal intervals, and the bottom end is also connected with an L-shaped scraper (18), the outer top of the reactor (1) and corresponding to the rotating rod (14) is equipped with a driving motor (9), the output end of the driving motor (9) is connected to the driving rod (13), and the second gear (11) is meshingly connected to the first gear (10).

3. The production reaction device of a pharmaceutical intermediate according to claim 1, characterized in that: The support assembly comprises a limiting ring (2) installed outside the reactor (1) and located on the bottom of the outer wall of the jacket (7), the outer bottom of the limiting ring (2) is connected to fixed columns (3) at equal intervals, and the outer bottoms of the four fixed columns (3) are connected to pads.

4. The production reaction device of a pharmaceutical intermediate according to claim 1, characterized in that: A conveying square tube (6) is obliquely inserted into the outer wall of the feed tube (4), and a sealing cover (19) is connected to the end of the discharge tube (5).

5. The production reaction device of a pharmaceutical intermediate according to claim 1, characterized in that: The outer side walls of the jacket (7) on both sides are respectively connected with an air inlet pipe and an air outlet pipe.

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