Dissolver for macromolecular drug analysis

Abstract

The utility model discloses a dissolver for macromolecular drug analysis, which comprises a dissolving tank, and the top of the dissolving tank is communicated with a dosing hopper; a second motor is installed at the top of the dissolving tank, a rotating shaft of the second motor penetrates through the top of the dissolving tank and is fixedly connected with a rotating rod, stirring blades are installed outside the rotating rod, and one end of the bottom of the rotating rod is rotatably installed on the inner wall of the bottom of the dissolving tank through a bearing; macromolecular drugs are put into the dissolving tank through the drug feeding hopper, meanwhile, dissolving liquid is put into the dissolving tank in proportion, the second motor drives the rotating rod and the stirring blades to stir and dissolve, the contact area is increased, dissolving is promoted, meanwhile, the rotating rod drives the grinding roller and the scraping plate to rotate at the bottom of the dissolving tank, and therefore the dissolving effect is improved. Undissolved medicine is ground and scraped, the dissolving efficiency is improved, and the phenomenon that residual medicine is attached to the bottom of the dissolving tank is reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of drug detection, in particular to a dissolver for macromolecular drug analysis. Background Art

[0002] The analysis and testing of macromolecular drugs can help ensure that the quality of the drugs meets standards and regulations. By analyzing the solubility and dissolution rate of macromolecular drugs, the speed and extent of their release in the body can be evaluated, thereby ensuring that the drugs can achieve the expected therapeutic effect. Among them, the dissolver used for drug dissolution refers to a device that mixes the drug with a solvent and dissolves it. The device can use stirring to accelerate dissolution and dispersion during the dissolution process.

[0003] However, when a common dissolver dissolves drugs, there are problems of undissolved or incompletely dissolved drug residues due to the adhesion or deposition of drugs at the bottom of the dissolution tank. These drug residues are difficult to move, resulting in uneven dissolution, which affects the dissolution quality and efficiency. Utility Model Content

[0004] The utility model aims to solve at least one of the technical problems existing in the prior art.

[0005] To this end, one purpose of the utility model is to provide a dissolver for macromolecular drug analysis, which utilizes the rotation of a rotating rod to drive a crushing roller and a scraper to rotate at the bottom of a dissolution tank, crushing and scraping undissolved drugs, thereby improving dissolution efficiency and reducing residual drugs.

[0006] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a dissolver for macromolecular drug analysis, comprising a dissolving tank, the top of which is connected to a drug feeding hopper; a second motor is installed on the top of the dissolving tank, the rotating shaft of the second motor passes through the top of the dissolving tank and is fixedly connected to a rotating rod, a stirring blade is installed on the outside of the rotating rod, one end of the bottom of the rotating rod is rotatably mounted on the bottom inner wall of the dissolving tank through a bearing, the bottom inner wall of the dissolving tank is fixedly connected to an annular rail, a rolling roller is installed on the outer wall of the rotating rod through a rotating shaft, a guide wheel is rotatably mounted on one end of the rolling roller, the guide wheel is slidably mounted inside the annular rail, and a scraper is fixedly connected to the outer wall of the rotating rod.

[0007] Preferably, two crushing rollers are symmetrically rotatably installed inside the medicine feeding hopper, the two crushing rollers are meshed with each other, one end of the two crushing rollers passes through the medicine feeding hopper and is fixedly connected to a transmission wheel, a first motor is installed on the outer wall of the medicine feeding hopper, the rotating shaft of the first motor is fixedly connected to one end of one of the transmission wheels, and belts are installed on the two transmission wheels.

[0008] Preferably, covers are installed on the outside of the first motor and the second motor.

[0009] Preferably, an electric heating plate is installed on the inner wall of the dissolving tank.

[0010] Preferably, the bottom of the dissolving tank is connected to a discharge pipe.

[0011] Preferably, the front surface of the scraper is provided with linear grooves.

[0012] Compared with the prior art, the utility model has the following beneficial effects: the utility model utilizes a drug feeding hopper to feed macromolecular drugs into a dissolution tank, and simultaneously feeds dissolving liquid in proportion; the second motor drives the rotating rod and the stirring blades to stir and dissolve, thereby increasing the contact area and promoting dissolution; at the same time, the rotating rod drives the rolling roller and the scraper to rotate at the bottom of the dissolution tank, thereby rolling and scraping undissolved drugs, thereby improving dissolution efficiency and reducing the phenomenon of residual drugs adhering to the bottom of the dissolution tank. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 This is a schematic diagram of the structure of a dissolver for macromolecular drug analysis according to an embodiment of the utility model;

[0014] Figure 2 This is a schematic cross-sectional view of the drug feeding hopper in the macromolecular drug analysis dissolver according to an embodiment of the present utility model;

[0015] Figure 3 This is a schematic diagram of the structure of the rolling roller and the annular rail in the dissolver for macromolecular drug analysis according to an embodiment of the utility model;

[0016] Figure 4 For the utility model embodiment Figure 1 Schematic diagram of the enlarged structure of part A.

[0017] In the figure: 1. dissolving tank; 2. dosing hopper; 3. first motor; 4. crushing roller; 5. second motor; 6. shield; 7. rotating rod; 8. electric heating plate; 9. stirring blade; 10. rolling roller; 11. discharge pipe; 12. transmission wheel; 13. belt; 14. guide wheel; 15. ring rail; 16. scraper; 17. linear groove. DETAILED DESCRIPTION

[0018] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0019] See also Figure 1The embodiment of the utility model provides a dissolver for macromolecular drug analysis, comprising: a dissolving tank 1 and a drug feeding hopper 2.

[0020] Among them, Figure 1 and Figure 3 As shown, the dosing hopper 2 is connected to the top of the dissolving tank 1, and a second motor 5 is installed on the top of the dissolving tank 1. The rotating shaft of the second motor 5 passes through the top of the dissolving tank 1 and is fixedly connected to a rotating rod 7. A stirring blade 9 is installed on the outside of the rotating rod 7. One end of the bottom of the rotating rod 7 is rotatably installed on the bottom inner wall of the dissolving tank 1 through a bearing.

[0021] When in use, the macromolecular drug to be dissolved is put into the dissolution tank 1 through the drug feeding hopper 2, and the dissolving liquid is put into the dissolving tank 1 in proportion through the drug feeding hopper 2. By starting the second motor 5 to drive the rotating rod 7 and the stirring blade 9 to rotate, the contact area between the drug and the dissolving liquid is accelerated to promote diffusion and dissolution.

[0022] Furthermore, an electric heating plate 8 is installed on the inner wall of the dissolving tank 1. After being started, the electric heating plate 8 can increase the temperature of the dissolved liquid in the dissolving tank 1, thereby improving the drug dissolution efficiency.

[0023] Among them, Figure 1-Figure 4 As shown, the bottom inner wall of the dissolving tank 1 is fixedly connected with an annular rail 15, the outer wall of the rotating rod 7 is installed with a rolling roller 10 through a rotating shaft, one end of the rolling roller 10 is rotatably installed with a guide wheel 14, the guide wheel 14 is slidably installed inside the annular rail 15, and the outer wall of the rotating rod 7 is fixedly connected with a scraper 16.

[0024] When the rotating rod 7 rotates, it can simultaneously drive the crushing roller 10 and the scraper 16 to rotate in a circular direction on the bottom inner wall of the dissolving tank 1. During the rotation process, the crushing roller 10 can crush the undissolved medicines deposited on the bottom inner wall of the dissolving tank 1 and the medicines attached to the bottom inner wall and unable to move, and at the same time use the scraper 16 to scrape the crushed medicines.

[0025] Furthermore, a linear groove 17 is provided on the front surface of the scraper 16 , which can reduce the weight of the scraper 16 and facilitate the passage of the solution when the scraper 16 rotates, thereby reducing the resistance of the scraper 16 when rotating.

[0026] Among them, Figure 1 and Figure 2 As shown, two crushing rollers 4 are symmetrically installed inside the medicine feeding hopper 2 for rotation. The two crushing rollers 4 are meshed with each other. One end of the two crushing rollers 4 passes through the medicine feeding hopper 2 and is fixedly connected to a transmission wheel 12. A first motor 3 is installed on the outer wall of the medicine feeding hopper 2. The rotating shaft of the first motor 3 is fixedly connected to one end of one of the transmission wheels 12. Belts 13 are installed on the two transmission wheels 12 for transmission.

[0027] When medicine is put into the medicine feeding hopper 2, the first motor 3 can drive one of the transmission wheels 12 to rotate, and use the belt 13 to drive the other transmission wheel 12 to operate, so that the two crushing rollers 4 can mesh and rotate with each other. The medicine can be squeezed and crushed when passing through the crushing roller 4, and the crushed medicine can enter the dissolving liquid and dissolve faster.

[0028] like Figure 1 As shown, shields 6 are installed outside the first motor 3 and the second motor 5 , and the shields 6 can cover and protect the first motor 3 and the second motor 5 .

[0029] Specifically, the bottom of the dissolving tank 1 is connected to a discharge pipe 11 , and the discharge pipe 11 is used to discharge the dissolved liquid from the dissolving tank 1 to the outside.

[0030] According to the above technical scheme, the working steps of this scheme are summarized and sorted out: when the utility model is used, the macromolecular drug to be dissolved is put into the dissolution tank 1 through the drug feeding hopper 2, and the dissolving liquid is put into the dissolving tank 1 in proportion through the drug feeding hopper 2 at the same time, and the second motor 5 is started to drive the rotating rod 7 and the stirring blade 9 to rotate, so as to accelerate the contact area between the drug and the dissolving liquid, make it easier for the molecules of the dissolving liquid to interact with the molecules of the drug, and promote diffusion and dissolution.

[0031] During the stirring and dissolving process, the rotating rod 7 can simultaneously drive the rolling roller 10 and the scraper 16 to rotate in a circular direction on the bottom inner wall of the dissolving tank 1. During the rotation process, the rolling roller 10 can roll the undissolved medicines deposited on the bottom inner wall of the dissolving tank 1 and the medicines attached to the bottom inner wall and cannot move. At the same time, the scraper 16 is used to scrape the crushed medicines, thereby accelerating the diffusion and dissolution of the medicines in the dissolving solution, improving the dissolution efficiency, and reducing the phenomenon of residual medicines attached to the bottom of the dissolving tank 1.

[0032] Parts not involved in the present invention are the same as the prior art or can be implemented by the prior art. Although the embodiments of the present invention have been shown and described, it is understood by those skilled in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the attached claims and their equivalents.

Claims

1. A dissolver for macromolecular drug analysis, comprising a dissolving tank (1), the top of which is connected to a drug feeding hopper (2), characterized in that: A second motor (5) is installed on the top of the dissolving tank (1), the rotating shaft of the second motor (5) passes through the top of the dissolving tank (1) and is fixedly connected to a rotating rod (7), the outside of the rotating rod (7) is installed with a stirring blade (9), one end of the bottom of the rotating rod (7) is rotatably mounted on the bottom inner wall of the dissolving tank (1) through a bearing, the bottom inner wall of the dissolving tank (1) is fixedly connected to an annular rail (15), a rolling roller (10) is installed on the outer wall of the rotating rod (7) through a rotating shaft, one end of the rolling roller (10) is rotatably mounted with a guide wheel (14), the guide wheel (14) is slidably mounted inside the annular rail (15), and a scraper (16) is fixedly connected to the outer wall of the rotating rod (7).

2. A dissolver for macromolecular drug analysis according to claim 1, characterized in that: Two crushing rollers (4) are symmetrically mounted inside the medicine feeding hopper (2), the two crushing rollers (4) are meshed with each other, one end of each of the two crushing rollers (4) passes through the medicine feeding hopper (2) and is fixedly connected to a transmission wheel (12), a first motor (3) is mounted on the outer wall of the medicine feeding hopper (2), a rotating shaft of the first motor (3) is fixedly connected to one end of one of the transmission wheels (12), and belts (13) are mounted on the two transmission wheels (12) for transmission.

3. A dissolver for macromolecular drug analysis according to claim 2, characterized in that: Shields (6) are installed outside the first motor (3) and the second motor (5).

4. A dissolver for macromolecular drug analysis according to claim 1, characterized in that: An electric heating plate (8) is installed on the inner wall of the dissolving tank (1).

5. A dissolver for macromolecular drug analysis according to claim 1, characterized in that: The bottom of the dissolving tank (1) is connected to a discharge pipe (11).

6. A dissolver for macromolecular drug analysis according to claim 1, characterized in that: The front surface of the scraper (16) is provided with a linear groove (17).

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