Subpackaging device for fluorescence coding microsphere reagent

Abstract

The utility model discloses a sub-packaging device for fluorescent coded microsphere reagents, which belongs to the technical field of sub-packaging of fluorescent coded microsphere reagents and comprises a cup body, a cup cover is connected to the top of the cup body in a covering mode through a buckle, an observation window is arranged on one side of the cup body, a rotating mechanism is arranged on the top of the cup cover, and the rotating mechanism is connected with the cup cover. A mixing mechanism is arranged in the cup body, and a connecting mechanism is arranged on one side of the cup body; the mixing mechanism comprises a rotatable rotating disc, a rotating rod is fixedly connected to the edge of the bottom of the rotating disc, a connecting ring is arranged in the cup body, the top of the connecting ring is obliquely arranged, when the rotating rod rotates, the connecting ring moves up and down, a rotating groove is formed in the bottom of the rotating rod, and the rotating rod is arranged in the rotating groove. The inner wall of the rotating groove is rotationally connected with a rotating ball, and the rotating ball is in rolling fit with the top inclined face of the connecting ring. The mixing device can realize the effect of uniform mixing.

Description

Technical Field

[0001] The utility model belongs to the technical field of fluorescent coding microsphere reagent subpackaging, and in particular relates to a subpackaging device for fluorescent coding microsphere reagent. Background Art

[0002] Fluorescently coded microsphere technology refers to the process of adding one or more fluorescent dyes or quantum dots of different concentrations into microspheres to make the microspheres have different fluorescence intensities, thereby forming a microsphere array with coding function. These microspheres can be coated with antibodies or nucleic acids of different specificities to make detection reagents, which can simultaneously perform high-throughput quantitative detection of multiple indicators in biological samples. Magnetic fluorescently coded microspheres are obtained by adding one or more fluorescent dyes or quantum dots of different concentrations into magnetic microspheres. The advantage of magnetic microspheres is that they do not require complex vacuum filtration or centrifugation processes. Through a simple magnetic separation device, high-purity separation of microspheres can be achieved in a short time. Due to the quenching problem of fluorescent dyes and the easy sedimentation of magnetic microspheres, the reagents containing magnetic fluorescently coded microspheres should not only pay attention to light protection during the packaging process to slow down the fluorescence quenching, but also pay attention to the sedimentation process of magnetic microspheres to prevent the concentration of magnetic microspheres in each reagent bottle from being different due to the sedimentation of magnetic microspheres. To reduce the difference between reagent bottles, a packaging device for fluorescently coded microsphere reagents is required.

[0003] At present, a Chinese patent with the announcement number CN220032536U discloses a stirring device for packaging reagents containing magnetic fluorescent coded microspheres, including: a cup body, which is hollow inside to form a cavity with an upper opening, the cavity is used to hold the reagent, the cup body includes an opaque main body made of opaque material and a transparent strip for the operator to observe the reagent liquid level in the cavity; a cup cover, which is connected to the cup body and closes the opening of the cavity, and the cup cover is provided with a liquid collection hole leading to the cavity; a stirrer, which is provided on the cup cover, and the stirrer is used to stir the reagent in the cavity. Except for the narrow transparent strip, the rest of the opaque main body of the cup body is opaque. The opaque cup body effectively reduces the influence of light on the reagent in the cup body cavity, so that the operator does not need to work in a dark environment; at the same time, during the reagent packaging process, the reagent in the cup body cavity can be continuously stirred by the stirrer to effectively prevent the reagent from settling.

[0004] However, when the above device is in use, when the stirrer is rotating, the reagents can only be rotated horizontally, and the reagents at the top and the reagents at the bottom are difficult to mix, and the mixing uniformity is poor. Utility Model Content

[0005] The purpose of the utility model is to solve the shortcomings of the prior art and to propose a packaging device for fluorescent coded microsphere reagents. The utility model has the advantages of achieving a uniform mixing effect.

[0006] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0007] A packaging device for fluorescent coded microsphere reagents, comprising a cup body, the top of the cup body is connected to a cup cover through a snap cover, one side of the cup body is provided with an observation window, the top of the cup cover is provided with a rotating mechanism, a mixing mechanism is provided in the cup body, and one side of the cup body is provided with a connecting mechanism;

[0008] The mixing mechanism comprises a rotatable rotating disk, the bottom edge of which is fixedly connected to a rotating rod, a connecting ring is arranged in the cup body, the top of the connecting ring is arranged obliquely, and when the rotating rod rotates, the connecting ring moves up and down.

[0009] Through the above technical scheme: when in use, the cup cover is replaced on the cup body, so that the stirring rod is aligned with the slide and moves down through the inner wall of the slide, and the rotating motor is started. The output shaft of the rotating motor rotates to rotate the rotating shaft, and the rotation of the rotating shaft can rotate the stirring rod, which can make the reagent rotate horizontally, and the rotation of the rotating shaft can make the rotating disk rotate, and the rotation of the rotating disk can make the rotating rod rotate, and the rotation of the rotating rod can apply force to the top of the connecting ring. At this time, the connecting block slides in the inner wall of the connecting groove, and the connecting ring can perform high-frequency up and down motion with the mixing plate, so that the top and bottom of the reagent can be mixed, thereby achieving a uniform mixing effect.

[0010] The utility model is further configured that a rotation groove is opened at the bottom of the rotation rod, and a rotation ball is rotatably connected to the inner wall of the rotation groove, and the rotation ball forms a rolling fit with the top inclined surface of the connecting ring.

[0011] Through the above technical solution: the setting of the rotating ball can reduce the sliding friction between the rotating rod and the top of the connecting ring, and can protect the equipment structure.

[0012] The utility model is further configured that a plurality of evenly distributed mixing plates are fixedly connected around the connection ring, and the mixing plates are arranged in an inclined manner.

[0013] Through the above technical solution: the inclined setting can compress the reagents, so that the reagents on the top and the reagents on the bottom can be mixed.

[0014] The utility model is further configured that the rotating mechanism includes a rotating motor fixedly connected to the top of the cup cover, the output shaft of the rotating motor is fixedly connected to a rotating shaft, and both sides of the rotating shaft are fixedly connected to a plurality of evenly distributed stirring rods.

[0015] Through the above technical solution: the setting of the rotating shaft can rotate under the rotation of the output shaft of the rotating motor, and the rotation of the rotating shaft can cause the stirring rod to rotate.

[0016] The utility model is further configured that the inner walls on both sides of the connecting ring are provided with sliding openings, and a sliding fit is formed between the inner walls of the sliding openings and the stirring rod.

[0017] Through the above technical solution: the setting of the sliding mouth can avoid interference between the connecting ring and the stirring rod.

[0018] The utility model is further configured that a spiral blade is fixedly connected to the surface of the rotating shaft.

[0019] Through the above technical solution: the setting of the spiral blades can make the reagents rise in a spiral, which can increase the mixing degree of the reagents.

[0020] The utility model is further configured such that the connecting mechanism comprises a connecting block fixedly connected to an outer wall of one side of the connecting ring, an inner wall of one side of the cup body is provided with a connecting groove which forms a sliding fit with the connecting block, and the connecting block and the inner wall of the connecting groove are both T-shaped structures.

[0021] Through the above technical solution: the connection block is arranged so as to slide in the inner wall of the connection groove, so that the position of the connection ring can be changed.

[0022] The utility model is further configured that a connecting spring is fixedly connected to the top of the connecting block, and the connecting spring is fixedly connected to the top inner wall of the connecting groove.

[0023] Through the above technical solution: the setting of the connecting spring can apply pressure to the connecting block, so that the connecting block can be quickly reset.

[0024] The beneficial effects of the utility model are:

[0025] 1. The packaging device for fluorescent coded microsphere reagent can rotate the stirring rod by rotating the rotating shaft, so that the reagent can be rotated horizontally. The rotation of the rotating shaft can rotate the rotating disk. The rotation of the rotating disk can rotate the rotating rod. The rotation of the rotating rod can apply force to the top of the connecting ring. At this time, the connecting block slides in the inner wall of the connecting groove. The connecting ring can perform high-frequency up and down motion with the mixing plate, so that the top and bottom of the reagent can be mixed, thereby achieving a uniform mixing effect.

[0026] 2. The packaging device for fluorescent coded microsphere reagents can rotate under the rotation of the output shaft of the rotating motor through the rotating shaft. The rotation of the rotating shaft can rotate the stirring rod. The sliding mouth can avoid interference between the connecting ring and the stirring rod. The spiral blades can make the reagents rise in a spiral, which can increase the mixing degree of the reagents. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1This is a schematic diagram of the three-dimensional structure of a packaging device for fluorescent coded microsphere reagents proposed by the utility model;

[0028] Figure 2 This is a partial cross-sectional structural schematic diagram of a packaging device for fluorescent coded microsphere reagents proposed by the utility model;

[0029] Figure 3 for Figure 2 Schematic diagram of the enlarged structure at point A in the middle.

[0030] In the figure: 1. cup body; 2. cup cover; 3. rotating disk; 4. rotating rod; 5. connecting ring; 6. rotating groove; 7. rotating ball; 8. mixing plate; 9. rotating motor; 10. rotating shaft; 11. stirring rod; 12. sliding mouth; 13. spiral blade; 14. connecting groove; 15. connecting block; 16. connecting spring. DETAILED DESCRIPTION

[0031] The technical solution of this patent is further described in detail below in conjunction with specific implementation methods.

[0032] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0033] In the description of this patent, it should be understood that the terms "center", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the drawings, and are only for the convenience of describing this patent and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on this patent.

[0034] In the description of this patent, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", and "set" should be understood in a broad sense, for example, it can be fixedly connected or set, or it can be detachably connected or set, or connected or set in one piece. For ordinary technicians in this field, the specific meanings of the above terms in this patent can be understood according to specific circumstances.

[0035] Reference Figure 1-3, a packaging device for fluorescent coded microsphere reagents, comprising a cup body 1, a cup cover 2 connected to the top of the cup body 1 through a snap cover, an observation window is provided on one side of the cup body 1, a rotating mechanism is provided on the top of the cup cover 2, a mixing mechanism is provided in the cup body 1, and a connecting mechanism is provided on one side of the cup body 1;

[0036] The mixing mechanism comprises a rotatable rotating disk 3, the bottom edge of which is fixedly connected to a rotating rod 4, a connecting ring 5 is arranged in the cup body 1, and the top of the connecting ring 5 is arranged at an angle. When the rotating rod 4 rotates, the connecting ring 5 moves up and down.

[0037] It should be noted that, in the present embodiment, a rotating groove 6 is provided at the bottom of the rotating rod 4, and a rotating ball 7 is rotatably connected to the inner wall of the rotating groove 6. The rotating ball 7 forms a rolling fit with the top inclined surface of the connecting ring 5. The rotating ball 7 can reduce the sliding friction between the rotating rod 4 and the top of the connecting ring 5, thereby protecting the equipment structure.

[0038] Furthermore, in this embodiment, a plurality of evenly distributed mixing plates 8 are fixedly connected around the connecting ring 5, and the mixing plates 8 are inclined. The inclined mixing plates 8 can compress the reagents, so that the reagents on the top and the bottom can be mixed.

[0039] In one specific embodiment, the rotating mechanism includes a rotating motor 9 fixedly connected to the top of the cup cover 2, the output shaft of the rotating motor 9 is fixedly connected to a rotating shaft 10, and a number of evenly distributed stirring rods 11 are fixedly connected on both sides of the rotating shaft 10. The rotating shaft 10 can be rotated when the output shaft of the rotating motor 9 rotates, and the rotation of the rotating shaft 10 can cause the stirring rod 11 to rotate.

[0040] It should be noted that, in this embodiment, both inner walls of the connecting ring 5 are provided with sliding openings 12 , and a sliding fit is formed between the inner wall of the sliding opening 12 and the stirring rod 11 , so that interference between the connecting ring 5 and the stirring rod 11 can be avoided.

[0041] Furthermore, in this embodiment, a spiral blade 13 is fixedly connected to the surface of the rotating shaft 10 , and the spiral blade 13 can make the reagent rise in a spiral manner, thereby increasing the mixing degree of the reagent.

[0042] In one specific embodiment, the connecting mechanism includes a connecting block 15 fixedly connected to an outer wall of one side of the connecting ring 5, and an inner wall of one side of the cup body 1 is provided with a connecting groove 14 that forms a sliding fit with the connecting block 15. The connecting block 15 and the inner wall of the connecting groove 14 are both T-shaped structures. The connecting block 15 can slide in the inner wall of the connecting groove 14, so that the position of the connecting ring 5 can be changed.

[0043] It should be noted that, in this embodiment, a connecting spring 16 is fixedly connected to the top of the connecting block 15, and the connecting spring 16 is fixedly connected to the top inner wall of the connecting groove 14. The connecting spring 16 can apply pressure to the connecting block 15, so that the connecting block 15 can be quickly reset.

[0044] Working principle: When in use, the cup cover 2 is replaced on the cup body 1, so that the stirring rod 11 is aligned with the sliding mouth 12 and moves down through the inner wall of the sliding mouth 12, and the rotating motor 9 is started. The output shaft of the rotating motor 9 rotates to rotate the rotating shaft 10, and the rotation of the rotating shaft 10 can rotate the stirring rod 11, which can make the reagent rotate horizontally, and the rotation of the rotating shaft 10 can rotate the rotating disk 3, and the rotation of the rotating disk 3 can rotate the rotating rod 4, and the rotation of the rotating rod 4 can apply force to the top of the connecting ring 5. At this time, the connecting block 15 slides in the inner wall of the connecting groove 14, and the connecting ring 5 can perform high-frequency up and down motion with the mixing plate 8, which can mix the top and bottom of the reagent, thereby achieving a uniform mixing effect.

[0045] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes within the technical scope disclosed by the present invention according to the technical scheme and the utility model concept of the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A packaging device for fluorescent coded microsphere reagents, comprising a cup body (1), the top of the cup body (1) is connected to a cup cover (2) via a snap cover, and one side of the cup body (1) is provided with an observation window, characterized in that: A rotating mechanism is arranged on the top of the cup cover (2), a mixing mechanism is arranged inside the cup body (1), and a connecting mechanism is arranged on one side of the cup body (1); The mixing mechanism comprises a rotatable rotating disk (3), the bottom edge of the rotating disk (3) is fixedly connected to a rotating rod (4), a connecting ring (5) is arranged inside the cup body (1), the top of the connecting ring (5) is arranged in an inclined manner, and when the rotating rod (4) rotates, the connecting ring (5) moves up and down.

2. A packaging device for fluorescent coded microsphere reagents according to claim 1, characterized in that: A rotating groove (6) is provided at the bottom of the rotating rod (4), and a rotating ball (7) is rotatably connected to the inner wall of the rotating groove (6), and the rotating ball (7) forms a rolling fit with the top inclined surface of the connecting ring (5).

3. A packaging device for fluorescent coded microsphere reagents according to claim 2, characterized in that: A plurality of evenly distributed mixing plates (8) are fixedly connected around the connection ring (5), and the mixing plates (8) are arranged in an inclined manner.

4. A packaging device for fluorescent coded microsphere reagents according to claim 1, characterized in that: The rotating mechanism comprises a rotating motor (9) fixedly connected to the top of the cup cover (2), the output shaft of the rotating motor (9) being fixedly connected to a rotating shaft (10), and a plurality of evenly distributed stirring rods (11) being fixedly connected to both sides of the rotating shaft (10).

5. A packaging device for fluorescent coded microsphere reagents according to claim 4, characterized in that: The inner walls on both sides of the connecting ring (5) are provided with sliding openings (12), and the inner walls of the sliding openings (12) form a sliding fit with the stirring rod (11).

6. A packaging device for fluorescent coded microsphere reagents according to claim 4, characterized in that: A spiral blade (13) is fixedly connected to the surface of the rotating shaft (10).

7. A packaging device for fluorescent coded microsphere reagents according to claim 1, characterized in that: The connection mechanism comprises a connection block (15) fixedly connected to an outer wall of one side of the connection ring (5); an inner wall of one side of the cup body (1) is provided with a connection groove (14) which forms a sliding fit with the connection block (15); and the inner wall of the connection block (15) and the connection groove (14) are both T-shaped structures.

8. A packaging device for fluorescent coded microsphere reagents according to claim 7, characterized in that: A connecting spring (16) is fixedly connected to the top of the connecting block (15), and the connecting spring (16) is fixedly connected to the top inner wall of the connecting groove (14).

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