Multi-channel large-volume nucleic acid extractor

Abstract

The utility model discloses a multi-channel large-volume nucleic acid extractor, which belongs to the technical field of nucleic acid extraction and comprises a bottom plate, and two groups of placing mechanisms distributed in parallel from left to right are mounted at the top end of the bottom plate; an extraction assembly is mounted at the upper end of the bottom plate; the extraction assembly comprises a linear moving assembly and a curve moving assembly, the linear moving assembly is connected with the bottom plate, and the linear moving assembly is connected with the curve moving assembly. Through the mode, the sample box is subjected to water area heating through the first water area heating box, the second water area heating box and the heating piece, the heating is uniform, the heating effect is good, the heating temperature is convenient to control, the magnetic bar sleeve and the magnetic bar can be driven to do sinusoidal motion in a sample liquid area, and lysate, nucleic acid and magnetic beads are fully and uniformly mixed.

Description

Technical Field

[0001] The utility model relates to the technical field of nucleic acid extraction, in particular to a multi-channel large-volume nucleic acid extraction instrument. Background Art

[0002] A nucleic acid extractor is a device used to extract nucleic acids from samples. It is usually used in molecular biology research and laboratory work. Common extraction methods include silica gel column method, magnetic bead method, phenol chloroform method, etc. These methods design extraction steps based on the physicochemical properties and binding characteristics of nucleic acids to obtain high-purity and high-quality nucleic acid samples.

[0003] Chinese patent CN219032199U discloses a nucleic acid extractor with a heat-insulating structure, comprising a shell, a decorative plate connected to the top of the bottom wall of the shell, two groups of placement mechanisms distributed in parallel from left to right are arranged on the top of the decorative plate, each group of the placement mechanisms includes a first placement plate connected to the decorative plate, a second placement plate connected to the decorative plate is arranged on one side of the first placement plate, a plurality of slots are opened on the top of the first placement plate and the second placement plate, sample boxes for storing sample liquid, rinse liquid and eluent are connected inside the slots, a heating film for heating the sample box is arranged at the bottom of the decorative plate, the heating film is connected to the bottom wall of the shell, and the first placement plate and the second placement plate are provided with heat-insulating sleeves connected to the decorative plate on the outside for isolating the heat emitted by the heating film to achieve continuous heat preservation of the sample box.

[0004] However, when the patent uses the heating film to heat the sample liquid, the sample liquid may be heated unevenly, the heating effect is poor, and it is inconvenient to control the heating temperature.

[0005] Based on this, the utility model designs a multi-channel large-volume nucleic acid extraction instrument to solve the above problems. Utility Model Content

[0006] In view of the above-mentioned shortcomings of the prior art, the utility model provides a multi-channel large-volume nucleic acid extraction instrument.

[0007] In order to achieve the above objectives, the present invention is implemented through the following technical solutions:

[0008] A multi-channel large-volume nucleic acid extraction instrument comprises a bottom plate;

[0009] Two groups of placement mechanisms are installed on the top of the bottom plate and are arranged in parallel from left to right;

[0010] An extraction assembly is installed at the upper end of the bottom plate;

[0011] The extraction component comprises a linear moving component and a curved moving component, wherein the linear moving component is connected to the bottom plate, and the linear moving component is connected to the curved moving component.

[0012] Furthermore, the placement mechanism includes a first water area heating box, a second water area heating box, a first placement rack, a second placement rack, a heating plate and a sample box. The first water area heating box and the second water area heating box are both fixedly connected to the top of the bottom plate. The tops of the first water area heating box and the second water area heating box are respectively fixedly connected with the first placement rack and the second placement rack for placing the sample boxes. The first placement rack and the second placement rack are both provided with a plurality of slots. The lower end inner walls of the first water area heating box and the second water area heating box are both fixedly connected with heating plates.

[0013] Furthermore, the sample box is composed of a sample liquid area, a rinse liquid area and an eluent area which are interconnected from left to right. The sample liquid area is plugged into the first water heating box through a slot on the first placement rack, and the eluent area is plugged into the second water heating box through a slot on the second placement rack. The slots on the first placement rack and the second placement rack are longitudinally distributed from front to back, and the slots on the first placement rack are distributed one-to-one with the slots on the second placement rack.

[0014] Furthermore, the linear motion assembly includes a transverse driving mechanism, a first vertical driving mechanism, a second vertical driving mechanism, a moving plate, a mounting plate, a linear guide, a guide rail assembly and a fixed block. A transverse driving mechanism is installed on the rear side of the upper end of the base plate, and the guide rails of the two sets of linear guides are fixedly connected to the rear side of the upper end of the base plate, and the driving end of the transverse driving mechanism and the slider of the linear guide are fixedly connected to the moving plate. The left and right ends of the moving plate are respectively connected to the first vertical driving mechanism and the second vertical driving mechanism, and the front end of the moving plate is fixedly connected to the mounting plate, the guide rail of the guide rail assembly is fixedly connected to the front end of the mounting plate, and the guide rail assembly is located between the first vertical driving mechanism and the second vertical driving mechanism, and the front ends of the two sliders of the guide rail assembly are fixedly connected to the fixed block, and the left rear end of the upper fixed block passes through the avoidance groove on the left side of the mounting plate and is fixedly connected to the driving end of the first vertical driving mechanism, and the right rear end of the lower fixed block passes through the avoidance groove on the right side of the mounting plate and is fixedly connected to the driving end of the second vertical driving mechanism.

[0015] Furthermore, the fixed block is connected to the curved moving component.

[0016] Furthermore, the first vertical driving mechanism and the second vertical driving mechanism are pulley driving mechanisms.

[0017] Furthermore, the curved moving assembly includes a fixed plate, a curved groove, a limit groove, a limit block, a moving rod, an electric cylinder, a magnetic rod sleeve, a magnetic rod frame and a connecting block. The front end of the fixed block is fixedly connected to the fixed plate, the front end of the fixed plate is provided with a curved groove, the upper and lower ends of the fixed plate are provided with limit grooves, the limit grooves are connected to the curved grooves, the upper and lower ends of the limit block are respectively embedded in the limit grooves on the upper and lower sides and are fitted and slidably connected with the limit grooves, the front end of the limit block is fixedly connected to the moving rod, the front end of the moving rod is fixedly connected to the connecting block, the front ends of the upper and lower connecting blocks are respectively fixedly connected to the magnetic rod frame and the magnetic rod sleeve frame, the left end of the fixed plate is fixedly connected to the electric cylinder, the output ends of the upper and lower electric cylinders are respectively movably connected to the connecting blocks on the upper and lower sides, and the moving rod is fitted and slidably connected with the curved groove.

[0018] Furthermore, the bottom of the left and right sides of the magnetic rod rack are detachably connected with a plurality of magnetic rods by screws, and the bottom of the left and right sides of the magnetic rod sleeve rack are clamped with a plurality of magnetic rod sleeves by slots, and the number of magnetic rods, magnetic rod sleeves and sample boxes is equal.

[0019] The utility model has the following technical effects:

[0020] When the utility model installs the sample box, the staff pours appropriate amounts of sample liquid, rinsing liquid and elution liquid in the sample liquid area, rinsing liquid area and elution liquid area of ​​the sample box respectively, and adds appropriate lysis liquid into the sample liquid. The staff places the sample liquid area in the first water area heating box through the slot on the first placement rack, and places the elution liquid area transversely in the second water area heating box through the slot on the second placement rack. The heating plate heats the water in the first water area heating box and the second water area heating box, thereby heating the sample box inside the first water area heating box and the second water area heating box, increasing the mixing rate of the sample liquid and the lysis liquid, increasing the release rate of the nucleic acid, strengthening the heating effect of the elution liquid, and accelerating the elution efficiency of the magnetic rod. The rinsing liquid area is between the first water area heating box and the second water area heating box, and is fully exposed to the outside world. The heating plate cannot heat this area, so as to avoid excessive heat here, resulting in evaporation of the rinsing liquid and waste of reagents.

[0021] The utility model heats the sample box in the water area through the first water area heating box, the second water area heating box and the heating sheet, and the heating is uniform, the heating effect is good, and the heating temperature is convenient to control;

[0022] After the sample box is installed, magnetic beads are added into the lysate. The second vertical driving mechanism drives the magnetic rod holder to move downward along the guide rail assembly, so that the magnetic rod holder drives the magnetic rod holder to insert into the sample liquid area and penetrate to the bottom. The electric cylinder drives the moving rod to make a sinusoidal motion to the right along the curved groove. The moving rod drives the limit block to move to the right along the limit groove to limit the moving rod. At the same time, the moving rod drives the fixed plate to make a sinusoidal motion to the right. The fixed plate drives the magnetic rod holder and the magnetic rod holder to make a sinusoidal motion to the right, thereby driving the magnetic rod holder to make a sinusoidal motion in the sample liquid area. The lysate, nucleic acid and magnetic beads are fully mixed, and the magnetic rod frame and the magnetic rod sleeve frame perform sinusoidal motion together, ensuring that the magnetic rod frame is always located directly above the magnetic rod sleeve frame, and the magnetic rod is always located directly above the magnetic rod sleeve, and then the first vertical driving mechanism drives the magnetic rod frame to move downward, so that the magnetic rod is inserted and penetrates into the bottom of the magnetic rod sleeve, so as to adsorb the magnetic beads to the magnetic rod sleeve. In the process of adsorbing the magnetic beads, the curved moving component can also drive the magnetic rod sleeve and the magnetic rod to perform sinusoidal motion, so as to completely adsorb the magnetic beads, improve the collection rate of the magnetic beads, and thus improve the efficiency and purity of the nucleic acid extraction;

[0023] After the utility model completes adsorption, the transverse driving mechanism drives the moving plate to move rightward along the linear guide rail, the moving plate drives the mounting plate to move rightward, the mounting plate drives the magnetic rod sleeve frame and the magnetic rod frame to move rightward, and the magnetic rod and the magnetic rod sleeve are moved to the rinsing liquid area and the elution liquid area, and then rinsing and elution are performed, thereby obtaining purified nucleic acid and completing the nucleic acid extraction process. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the prior art descriptions are briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model, and for ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0025] Figure 1 The utility model is a three-dimensional multi-channel large-volume nucleic acid extraction instrument Figure 1 ;

[0026] Figure 2 It is a front view of a multi-channel large-volume nucleic acid extraction instrument of the utility model;

[0027] Figure 3 It is a left view of a multi-channel large-volume nucleic acid extraction instrument of the utility model;

[0028] Figure 4 The utility model is a three-dimensional multi-channel large-volume nucleic acid extraction instrument Figure 2 ;

[0029] Figure 5The utility model is a three-dimensional multi-channel large-volume nucleic acid extraction instrument Figure 3 ;

[0030] Figure 6 For along Figure 3 AA direction cross-sectional view;

[0031] Figure 7 for Figure 4 The enlarged view of point B in the middle;

[0032] Figure 8 for Figure 6 Enlarged view of point C in the middle.

[0033] The numbers in the figure represent:

[0034] 1. Bottom plate; 2. Placement mechanism; 21. First water area heating box; 22. Second water area heating box; 23. First placement rack; 24. Second placement rack; 25. Heating plate; 26. Sample box; 261. Sample liquid area; 262. Rinsing liquid area; 263. Eluent area; 3. Extraction component; 31. Linear moving component; 311. Horizontal driving mechanism; 312. First vertical driving mechanism; 313. Second vertical driving mechanism; 314. Moving plate; 315. Mounting plate; 316. Linear guide rail; 317. Guide rail assembly; 318. Fixed block; 32. Curved moving component; 321. Fixed plate; 322. Curved groove; 323. Limiting groove; 324. Limiting block; 325. Moving rod; 326. Electric cylinder; 327. Magnetic rod holder; 328. Magnetic rod holder; 329. Connecting block. DETAILED DESCRIPTION

[0035] In order to make the purpose, technical solution and advantages of the embodiment of the utility model clearer, the technical solution in the embodiment of the utility model will be clearly and completely described below in conjunction with the drawings in the embodiment of the utility model. Obviously, the described embodiment is a part of the embodiment of the utility model, not all of the embodiments. Based on the embodiment of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0036] The utility model is further described below in conjunction with embodiments.

[0037] The terms “left”, “right”, “front”, “back”, “up” and “down” mentioned in the following description are oriented in the viewing direction of the front view.

[0038] In some embodiments, please refer to the attached instructions. Figure 1-8 , a multi-channel large-volume nucleic acid extraction instrument, comprising a bottom plate 1;

[0039] Two sets of placement mechanisms 2 are installed on the top of the bottom plate 1 and are arranged in parallel from left to right;

[0040] An extraction assembly 3 is installed at the upper end of the bottom plate 1;

[0041] The extraction component 3 includes a linear moving component 31 and a curvilinear moving component 32 . The linear moving component 31 is connected to the base plate 1 , and the linear moving component 31 and the curvilinear moving component 32 are connected.

[0042] Taking the placement mechanism 2 on the left as an example, the placement mechanism 2 includes a first water area heating box 21, a second water area heating box 22, a first placement rack 23, a second placement rack 24, a heating plate 25 and a sample box 26. The first water area heating box 21 and the second water area heating box 22 are both fixedly connected to the top of the bottom plate 1. The tops of the first water area heating box 21 and the second water area heating box 22 are respectively fixedly connected with the first placement rack 23 and the second placement rack 24 for placing the sample box 26. The first placement rack 23 and the second placement rack 24 are both provided with a plurality of slots. The lower end inner walls of the first water area heating box 21 and the second water area heating box 22 are both fixedly connected with the heating plate 25.

[0043] The sample box 26 consists of a sample liquid area 261, a rinse liquid area 262 and an eluent area 263 which are interconnected from left to right. The sample liquid area 261 is plugged into the first water area heating box 21 through a slot on the first placement rack 23, and the eluent area 263 is plugged into the second water area heating box 22 through a slot on the second placement rack 24. The slots on the first placement rack 23 and the second placement rack 24 are longitudinally distributed from front to back, and the slots on the first placement rack 23 correspond to the slots on the second placement rack 24 one by one.

[0044] When installing the sample box 26, the staff pours appropriate amounts of sample liquid, rinsing liquid and eluent into the sample liquid area 261, the rinsing liquid area 262 and the eluent area 263 of the sample box 26 respectively, and adds appropriate lysis liquid into the sample liquid. The staff places the sample liquid area 261 in the first water area heating box 21 through the slot on the first placement rack 23, and places the eluent area 263 transversely in the second water area heating box 22 through the slot on the second placement rack 24. The heating plate 25 heats the water in the first water area heating box 21 and the second water area heating box 22, thereby heating the sample box 26 inside the first water area heating box 21 and the second water area heating box 22, increasing the mixing rate of the sample liquid and the lysis liquid, increasing the release rate of the nucleic acid, strengthening the heating effect of the eluent, and accelerating the elution efficiency of the magnetic rod. The rinsing liquid area 262 is located between the first water area heating box 21 and the second water area heating box 22, and is fully exposed to the outside world. The heating plate 25 cannot heat this area to avoid excessive heat here, resulting in volatilization of the rinsing liquid and waste of reagents.

[0045] The utility model heats the sample box 26 in the water area through the first water area heating box 21, the second water area heating box 22 and the heating sheet 25, and the heating is uniform, the heating effect is good, and the heating temperature is convenient to control;

[0046] The linear motion assembly 31 comprises a transverse driving mechanism 311, a first vertical driving mechanism 312, a second vertical driving mechanism 313, a moving plate 314, a mounting plate 315, a linear guide rail 316, a guide rail assembly 317 and a fixed block 318. The transverse driving mechanism 311 is installed on the rear side of the upper end of the base plate 1. The guide rails of the two sets of linear guide rails 316 are fixedly connected to the rear side of the upper end of the base plate 1. The driving end of the transverse driving mechanism 311 and the slider of the linear guide rail 316 are fixedly connected to the moving plate 314. The left and right ends of the moving plate 314 are respectively connected to the first vertical driving mechanism 312 and the second vertical driving mechanism 313. The front end of the movable plate 314 is fixedly connected to the mounting plate 315, the guide rail of the guide rail assembly 317 is fixedly connected to the front end of the mounting plate 315, and the guide rail assembly 317 is located between the first vertical driving mechanism 312 and the second vertical driving mechanism 313, and the front ends of the two sliders of the guide rail assembly 317 are fixedly connected to the fixed blocks 318, and the rear end of the left side of the upper fixed block 318 passes through the avoidance groove on the left side of the mounting plate 315 and is fixedly connected to the driving end of the first vertical driving mechanism 312, and the rear end of the right side of the lower fixed block 318 passes through the avoidance groove on the right side of the mounting plate 315 and is fixedly connected to the driving end of the second vertical driving mechanism 313.

[0047] The fixed block 318 is connected to the curved moving assembly 32 .

[0048] The lateral driving mechanism 311 includes a motor and a threaded rod. The motor is fixedly connected to the rear side of the upper end of the base plate 1. The output end of the motor is fixedly connected to one end of the threaded rod. The other end of the threaded rod passes through the movable plate 314 and is fixedly connected to the base plate 1. The threaded rod is threadedly connected to the movable plate 314.

[0049] Preferably, the first vertical driving mechanism 312 and the second vertical driving mechanism 313 are pulley driving mechanisms.

[0050] The curve moving assembly 32 includes a fixed plate 321, a curve groove 322, a limit groove 323, a limit block 324, a moving rod 325, an electric cylinder 326, a magnetic rod sleeve 327, a magnetic rod frame 328 and a connecting block 329. The front end of the fixed block 318 is fixedly connected to the fixed plate 321. The front end of the fixed plate 321 is provided with a curve groove 322. The upper and lower ends of the fixed plate 321 are provided with limit grooves 323. The limit groove 323 is connected to the curve groove 322. The upper and lower ends of the limit block 324 are respectively embedded in the upper and lower sides. The limiting block 324 is in a sliding connection with the limiting groove 323, the front end of the limiting block 324 is fixedly connected with a moving rod 325, the front end of the moving rod 325 is fixedly connected with a connecting block 329, the front ends of the upper and lower connecting blocks 329 are respectively fixedly connected with the magnetic rod frame 328 and the magnetic rod sleeve frame 327, the left end of the fixed plate 321 is fixedly connected with an electric cylinder 326, the output ends of the upper and lower electric cylinders 326 are respectively movably connected with the upper and lower connecting blocks 329, and the moving rod 325 is slidingly connected with the curved groove 322.

[0051] The bottom of the left and right sides of the magnetic rod rack 328 are detachably connected with a plurality of magnetic rods by screws, and the bottom of the left and right sides of the magnetic rod sleeve rack 327 are clamped with a plurality of magnetic rod sleeves by slots, and the number of magnetic rods, magnetic rod sleeves and sample boxes 26 is equal.

[0052] After the sample box 26 is installed, magnetic beads are added to the lysate, and the second vertical driving mechanism 313 drives the magnetic rod holder 327 to move downward along the guide rail assembly 317, so that the magnetic rod holder 327 drives the magnetic rod holder to insert into the sample liquid area 261 and penetrate to the bottom, and the electric cylinder 326 drives the moving rod 325 to make a sinusoidal motion to the right along the curved groove 322, and the moving rod 325 drives the limiting block 324 to move right along the limiting groove 323 to limit the moving rod 325, and at the same time, the moving rod 325 drives the fixing plate 321 to make a sinusoidal motion to the right, and the fixing plate 321 drives the magnetic rod holder 327 and the magnetic rod holder 328 to make a sinusoidal motion to the right, thereby driving the magnetic rod holder 327 and the magnetic rod holder 328 to make a sinusoidal motion to the right. The rod sleeve performs sinusoidal motion in the sample liquid area 261 to fully mix the lysate, nucleic acid and magnetic beads. The magnetic rod frame 328 and the magnetic rod sleeve frame 327 perform sinusoidal motion together, ensuring that the magnetic rod frame 328 is always located directly above the magnetic rod sleeve frame 327, and the magnetic rod is always located directly above the magnetic rod sleeve. Then the first vertical driving mechanism 312 drives the magnetic rod frame 328 to move downward, so that the magnetic rod is inserted and penetrates into the bottom of the magnetic rod sleeve to adsorb the magnetic beads to the magnetic rod sleeve. In the process of adsorbing the magnetic beads, the curved moving component 32 can also drive the magnetic rod sleeve and the magnetic rod to perform sinusoidal motion to completely adsorb the magnetic beads, thereby improving the collection rate of the magnetic beads, and thus improving the efficiency and purity of the nucleic acid extraction.

[0053] After adsorption, the transverse driving mechanism 311 drives the movable plate 314 to move to the right along the linear guide rail 316, the movable plate 314 drives the mounting plate 315 to move to the right, the mounting plate 315 drives the magnetic rod sleeve 327 and the magnetic rod rack 328 to move to the right, and moves the magnetic rod and the magnetic rod sleeve to the rinsing liquid area 262 and the elution liquid area 263, and then rinses and elutes, thereby obtaining purified nucleic acid and completing the nucleic acid extraction process.

[0054] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments may still be modified, or some of the technical features may be replaced by equivalents. Such modifications or replacements will not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A multi-channel large-volume nucleic acid extraction instrument, comprising a bottom plate (1), characterized in that: Two groups of placement mechanisms (2) are installed on the top of the bottom plate (1) and are arranged in parallel from left to right; An extraction assembly (3) is installed at the upper end of the bottom plate (1); The extraction component (3) comprises a linear moving component (31) and a curved moving component (32); the linear moving component (31) is connected to the bottom plate (1); and the linear moving component (31) and the curved moving component (32) are connected.

2. The multi-channel large-volume nucleic acid extraction instrument according to claim 1, characterized in that: The placement mechanism (2) comprises a first water area heating box (21), a second water area heating box (22), a first placement rack (23), a second placement rack (24), a heating plate (25) and a sample box (26); the first water area heating box (21) and the second water area heating box (22) are both fixedly connected to the top of the bottom plate (1); the tops of the first water area heating box (21) and the second water area heating box (22) are respectively fixedly connected with the first placement rack (23) and the second placement rack (24) for placing the sample box (26); the first placement rack (23) and the second placement rack (24) are both provided with a plurality of slots; the lower inner walls of the first water area heating box (21) and the second water area heating box (22) are both fixedly connected with the heating plate (25).

3. The multi-channel large-volume nucleic acid extraction instrument according to claim 2, characterized in that: The sample box (26) is composed of a sample liquid area (261), a rinse liquid area (262) and an eluent area (263) which are connected to each other from left to right. The sample liquid area (261) is inserted into the first water area heating box (21) through a slot on the first placement rack (23), and the eluent area (263) is inserted into the second water area heating box (22) through a slot on the second placement rack (24). The slots on the first placement rack (23) and the second placement rack (24) are longitudinally distributed from front to back, and the slots on the first placement rack (23) and the slots on the second placement rack (24) are distributed one by one.

4. The multi-channel large-volume nucleic acid extraction instrument according to claim 3, characterized in that: The linear motion assembly (31) comprises a transverse driving mechanism (311), a first vertical driving mechanism (312), a second vertical driving mechanism (313), a moving plate (314), a mounting plate (315), a linear guide rail (316), a guide rail assembly (317) and a fixed block (318); the transverse driving mechanism (311) is installed on the rear side of the upper end of the base plate (1); the guide rails of the two sets of linear guide rails (316) are fixedly connected to the rear side of the upper end of the base plate (1); the driving end of the transverse driving mechanism (311) and the slider of the linear guide rail (316) are fixedly connected to the moving plate (314); the left and right ends of the moving plate (314) are respectively connected to the first vertical driving mechanism (312) and the second vertical driving mechanism (313); and the right and left ends of the moving plate (314) are respectively connected to the first vertical driving mechanism (312) and the second vertical driving mechanism (313). The front end of the movable plate (314) is fixedly connected to the mounting plate (315), the guide rail of the guide rail assembly (317) is fixedly connected to the front end of the mounting plate (315), and the guide rail assembly (317) is located between the first vertical driving mechanism (312) and the second vertical driving mechanism (313), the front ends of the two sliders of the guide rail assembly (317) are fixedly connected to the fixing blocks (318), the left rear end of the upper fixing block (318) passes through the avoidance groove on the left side of the mounting plate (315) and is fixedly connected to the driving end of the first vertical driving mechanism (312), and the right rear end of the lower fixing block (318) passes through the avoidance groove on the right side of the mounting plate (315) and is fixedly connected to the driving end of the second vertical driving mechanism (313).

5. The multi-channel large-volume nucleic acid extraction instrument according to claim 4, characterized in that: The fixed block (318) is connected to the curved moving assembly (32).

6. The multi-channel large-volume nucleic acid extraction instrument according to claim 5, characterized in that: The first vertical driving mechanism (312) and the second vertical driving mechanism (313) are pulley driving mechanisms.

7. The multi-channel large-volume nucleic acid extraction instrument according to claim 6, characterized in that: The curved moving assembly (32) comprises a fixed plate (321), a curved groove (322), a limiting groove (323), a limiting block (324), a moving rod (325), an electric cylinder (326), a magnetic rod sleeve (327), a magnetic rod frame (328) and a connecting block (329); the front end of the fixed block (318) is fixedly connected to the fixed plate (321); the front end of the fixed plate (321) is provided with a curved groove (322); the upper and lower ends of the fixed plate (321) are provided with limiting grooves (323); the limiting grooves (323) are communicated with the curved groove (322); the upper and lower ends of the limiting block (324) are respectively embedded in the fixing plate (321); The upper and lower limit grooves (323) are in close contact with and slidably connected to the limit grooves (323); the front end of the limit block (324) is fixedly connected with a moving rod (325); the front end of the moving rod (325) is fixedly connected with a connecting block (329); the front ends of the upper and lower connecting blocks (329) are respectively fixedly connected to a magnetic rod frame (328) and a magnetic rod sleeve frame (327); the left ends of the fixed plate (321) are both fixedly connected with an electric cylinder (326); the output ends of the upper and lower electric cylinders (326) are respectively movably connected to the upper and lower connecting blocks (329); and the moving rod (325) is in close contact with and slidably connected to the curved groove (322).

8. The multi-channel large-volume nucleic acid extraction instrument according to claim 7, characterized in that: The bottom of the left and right sides of the magnetic rod rack (328) are detachably connected to a plurality of magnetic rods via screws, and the bottom of the left and right sides of the magnetic rod sleeve rack (327) are clamped with a plurality of magnetic rod sleeves via clamping slots, and the number of magnetic rods, magnetic rod sleeves and sample boxes (26) is equal.

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