Non-derivatization tandem mass spectrometry detection kit
By designing a placement box with sliding connection and articulation structure, the problem that existing detection kits are inconvenient for storage and access to 96-well plates and reagent tubes is solved, and convenient operation and efficient use are achieved.
Patent Information
- Application Number
- CN202421333821.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-06-12
- Publication Date
- 2025-03-04
- Estimated Expiration
- 2034-06-12
AI Technical Summary
The existing non-derivative tandem mass spectrometry detection kits are not convenient to store or take up 96-well plates and reagent tubes easily, and there are certain limitations.
A non-derivative tandem mass spectrometry detection kit including a placement box slidingly connected to an L-shaped plate is designed, and the placement box can be folded and unfolded through the hinge and linkage structure, which facilitates the storage and access of the reagent tube and 96-well plate.
The device is easy to use, and the reagent tube and 96-well plate can be easily picked up or stored, improving the convenience and efficiency of operation.
Smart Images
Figure CN222555522U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to a kit technology, in particular to a non-derivatized tandem mass spectrometry detection kit. Background Art
[0002] A method for detecting acylcarnitines by non-derivatized tandem mass spectrometry was established for the detection and screening of organic acid and fatty acid metabolic diseases. The free carnitine and acylcarnitine in the filter paper dried blood smear were extracted with a solvent containing 13 stable isotope-labeled acylcarnitine internal standards, and the samples were directly injected into the tandem mass spectrometer. The experimental steps were as follows: samples were taken on the filter paper blood smear with a 3 mm diameter puncher and placed in a 96-well plate. 100 μL of methanol and acylcarnitine isotope internal standard mixture was added to each well, and the plate was sealed and incubated at 45°C with shaking (650-750 r / min) for 45 min. 75 μL of the extract was extracted and transferred to a V-bottom detection plate, covered with aluminum film, and tested on the machine.
[0003] Currently, non-derivatized tandem mass spectrometry detection kits are often not convenient for storing or taking out 96-well plates and reagent tubes, and have certain limitations. Utility Model Content
[0004] The utility model aims to provide a non-derivatized tandem mass spectrometry detection kit, which is used to solve the problem that the existing non-derivatized tandem mass spectrometry detection kits are often not convenient for storing or taking out 96-well plates and reagent tubes.
[0005] In order to solve the above problems, the utility model provides a non-derivatized tandem mass spectrometry detection kit, including a placement box slidably connected to an L-shaped plate, the bottoms of both sides of the L-shaped plate are respectively hinged with side panels, the front side of the L-shaped plate is hinged with a guard plate, the bottoms of both sides of the placement box are respectively hinged with connecting rods, the free ends of the connecting rods are respectively hinged with the corresponding side panels, the bottom of the front side of the placement box is hinged with a support rod, the free end of the support rod is hinged with the guard plate, a placement frame is fixed on the inner side of the guard plate, and sockets are respectively provided on the left and right sides of the placement box.
[0006] The non-derivatized tandem mass spectrometry detection kit provided by the utility model also has the following technical features:
[0007] Furthermore, the left and right sides of the placement box are respectively provided with stepped grooves, the insertion holes are arranged on the stepped surfaces of the stepped grooves, and the insertion holes are arranged in an inclined shape.
[0008] Furthermore, a handle is fixed on the top of the placement box.
[0009] Furthermore, a placement slot is provided on the front side of the placement box.
[0010] Furthermore, a positioning groove is provided on the back of the placement box, a limiting groove is provided on the L-shaped plate, a convex rod is slidably connected in the limiting groove, one end of the convex rod can be inserted into the positioning groove, and the other end of the convex rod extends out of the L-shaped plate.
[0011] Furthermore, the stepped surface of the convex rod is connected to the L-shaped plate via a spring.
[0012] The utility model has the following beneficial effects: the device is in a box-shaped folded state under normal conditions. When the device is used, the placement box is pulled upward so that the guard plate tilts forward under the action of the support rod, and the two side plates are opened respectively under the action of the corresponding connecting rods, so that the reagent tubes in the jacks on both sides of the placement box are easy to take out or store, and after the guard plate tilts forward, the 96-well plate placed in the placement frame is easy to take out or store, so that the device is easy to use, and further the device is easy to use in non-derivatized tandem mass spectrometry detection. BRIEF DESCRIPTION OF THE DRAWINGS
[0013] Figure 1 It is an axonometric diagram of an embodiment of the utility model;
[0014] Figure 2 A folding state diagram of an embodiment of the utility model;
[0015] Figure 3 A three-dimensional diagram of an embodiment of the utility model;
[0016] Figure 4 It is a right side cutaway view of an embodiment of the present utility model. DETAILED DESCRIPTION
[0017] The present invention will be described in detail below with reference to the accompanying drawings and in combination with embodiments. It should be noted that the embodiments and features in the embodiments of the present invention can be combined with each other without conflict.
[0018] like Figures 1 to 4In the embodiment of the non-derivatized tandem mass spectrometry detection kit of the utility model shown, the non-derivatized tandem mass spectrometry detection kit includes a placement box 2 slidably connected to an L-shaped plate 1, the bottoms of both sides of the L-shaped plate 1 are respectively hinged with side panels 3, the front side of the L-shaped plate 1 is hinged with a guard plate 4, the bottoms of both sides of the placement box 2 are respectively hinged with connecting rods 5, the free ends of the connecting rods 5 are respectively hinged with the corresponding side panels 3, the bottom of the front side of the placement box 2 is hinged with a support rod 6, the free end of the support rod 6 is hinged with the guard plate 4, the inner side of the guard plate 4 is fixed with a placement frame 7, and the placement box 2 is provided with a plurality of support rods 6. There are respectively provided with insertion holes 8 on the left and right sides of the placement box 2. Under normal circumstances, the device is in a box-shaped folded state. When the device is used, by pulling the placement box 2 upward, the guard plate 4 is tilted forward under the action of the support rod 6, and the two side plates 3 are respectively opened under the action of the corresponding connecting rods 5, so that the reagent tubes in the insertion holes 8 on both sides of the placement box 2 are convenient for taking or storing, and after the guard plate 4 is tilted forward, the 96-well plate placed in the placement frame 7 is convenient for taking or storing, so that the device is convenient to use, and further convenient for the device to be used in non-derivatized tandem mass spectrometry detection.
[0019] In one embodiment of the present application, preferably, stepped grooves 9 are respectively provided on the left and right sides of the placement box 2, and the insertion holes 8 are opened on the stepped surfaces of the stepped grooves 9. The insertion holes 8 are arranged in an inclined shape, so that the reagent tubes placed in the multiple insertion holes 8 are distributed in an inclined stepped shape, thereby facilitating the taking of the reagent tubes.
[0020] In one embodiment of the present application, preferably, a handle 10 is fixed to the top of the placement box 2, and the placement box 2 can be pulled to move upward by pulling the handle 10.
[0021] In one embodiment of the present application, preferably, a placement groove 11 is opened on the front side of the placement box 2, and reagent tubes or other supplies can be temporarily placed in the placement groove 11.
[0022] In one embodiment of the present application, preferably, a positioning groove is provided on the back of the placement box 2, and a limiting groove is provided on the L-shaped plate 1. A convex rod 12 is slidably connected in the limiting groove. One end of the convex rod 12 can be inserted into the positioning groove, and the other end of the convex rod 12 extends out of the L-shaped plate 1. When the placement box 2 moves upward to a certain position, one end of the convex rod 12 can be inserted into the positioning groove, thereby fixing the position of the placement box 2.
[0023] In one embodiment of the present application, preferably, the stepped surface of the convex rod 12 is connected to the L-shaped plate 1 via a spring, so that the convex rod 12 can be inserted into the positioning groove under the action of the spring.
[0024] When the utility model is in use, the device is in a box-shaped folded state under normal conditions. When the device is used, the handle 10 is held to pull the placement box 2 upward, so that the guard plate 4 tilts forward under the action of the support rod 6, and the two side plates 3 are opened respectively under the action of the corresponding connecting rods 5. When the placement box 2 moves upward to a certain position, one end of the convex rod 12 can be inserted into the positioning groove under the action of the spring, thereby playing a role in fixing the position of the placement box 2. Due to the position setting of the step groove 9 and the socket 8, the reagent tubes placed in the multiple sockets 8 are distributed in an inclined step shape, so that it is easy to take the reagent tubes, and after the guard plate 4 tilts forward, the 96-well plate placed in the placement frame 7 is easy to take or store, so that the device is easy to use, and the placement groove 11 can temporarily place reagent tubes or other supplies.
[0025] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the utility model, rather than to limit it. Although the utility model has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the various embodiments of the utility model.
Claims
1. A non-derivatized tandem mass spectrometry detection kit, comprising a placement box (2) slidably connected to an L-shaped plate (1), characterized in that: The bottoms of both sides of the L-shaped plate (1) are hinged with side plates (3), the front side of the L-shaped plate (1) is hinged with a guard plate (4), the bottoms of both sides of the placement box (2) are hinged with connecting rods (5), the free ends of the connecting rods (5) are hinged with the corresponding side plates (3), the bottom of the front side of the placement box (2) is hinged with a support rod (6), the free end of the support rod (6) is hinged with the guard plate (4), a placement frame (7) is fixed on the inner side of the guard plate (4), and the left and right sides of the placement box (2) are respectively provided with insertion holes (8).
2. The non-derivatized tandem mass spectrometry detection kit according to claim 1, characterized in that: The left and right sides of the placement box (2) are respectively provided with stepped grooves (9), the insertion hole (8) is opened on the stepped surface of the stepped groove (9), and the insertion hole (8) is arranged in an inclined shape.
3. The non-derivatized tandem mass spectrometry detection kit according to claim 1, characterized in that: A handle (10) is fixed on the top of the placement box (2).
4. The non-derivatized tandem mass spectrometry detection kit according to claim 1, characterized in that: The front side of the placement box (2) is provided with a placement groove (11).
5. The non-derivatized tandem mass spectrometry detection kit according to claim 1, characterized in that: The back of the placement box (2) is provided with a positioning groove, and the L-shaped plate (1) is provided with a limiting groove, in which a convex rod (12) is slidably connected, one end of the convex rod (12) can be inserted into the positioning groove, and the other end of the convex rod (12) extends out of the L-shaped plate (1).
6. The non-derivatized tandem mass spectrometry detection kit according to claim 5, characterized in that: The stepped surface of the convex rod (12) is connected to the L-shaped plate (1) via a spring.