Refining reaction equipment for 2, 4, 5-trifluorophenylacetic acid

Abstract

The utility model discloses refining reaction equipment for 2, 4, 5-trifluorophenylacetic acid, which comprises an equipment frame body, a heating reaction container, a cooling reaction container, a stirring device and a crystallization filter box, end covers are arranged on the heating reaction container and the cooling reaction container, liquid inlet end pipes are arranged on the end covers, and a liquid outlet end pipe is arranged on the crystallization filter box. The stirring device comprises a driving stirring motor, a reduction gearbox I, a shaft seat, a driving shaft, a helical ribbon and a connecting rod, a lifting mechanism is arranged on the equipment frame body, a movable frame is arranged on the lifting mechanism in a lifting mode, and the movable frame is fixedly installed on one side of the reduction gearbox I. The heating reaction container is provided with a heating cavity, and an electromagnetic heating coil is arranged in the heating cavity. The heating reaction container is provided with an output joint, the output joint is provided with a pressurizing output pipe, a cooling coil is arranged in the cooling reaction container, and the cooling reaction container is provided with a downward output pipe. The device has the functions of integrated heating, cooling, crystallizing and mixing, the interior of the container and a stirring device can be conveniently and thoroughly cleaned, and the mixing reaction sufficiency can be improved.

Description

Technical Field

[0001] The utility model relates to the technical field of chemical industry, in particular to a refining reaction device for 2,4,5-trifluorophenylacetic acid. Background Art

[0002] 2,4,5-Trifluorophenylacetic acid is an intermediate of the anti-type 2 diabetes drug sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 inhibitor and anti-type 2 diabetes drug developed by Merck in the United States. Sitagliptin can prevent and treat type 2 diabetes, hyperglycemia, insulin resistance, obesity and hypertension as well as certain complications.

[0003] At present, in the process of preparing 2,4,5-trifluorophenylacetic acid, a refining reaction is required to improve the quality. In the refining reaction process, the heating, cooling, crystallization and mixing functions required by the process need to be realized to obtain 2,4,5-trifluorophenylacetic acid solid. Therefore, a refining reaction equipment for mixing reaction is required in the preparation process. However, the existing refining reaction equipment of this type cannot integrate multiple functions of heating, cooling, crystallization and mixing. The processes are carried out separately, and the efficiency is low. Secondly, once the preparation is completed, there will be some residues on the stirring device and the inner wall of the container. Crystals will also be attached during cooling and are not easy to fall off. Therefore, they need to be cleaned. Generally, this type of equipment installs the stirring device in the container of the refining reaction equipment, which makes it difficult to clean the inside of the container and the stirring device, resulting in incomplete cleaning. In addition, the adequacy of the mixing reaction is also currently required to be improved, so it is necessary to improve it. Utility Model Content

[0004] In order to solve the problems raised in the above background technology, the utility model provides a refining reaction device for 2,4,5-trifluorophenylacetic acid, which has the functions of concentrated heating, cooling, crystallization and mixing, is convenient for thoroughly cleaning the inside of the container and the stirring device, and can improve the adequacy of the mixing reaction.

[0005] To achieve the above object, the utility model provides the following technical solutions: a refining reaction device for 2,4,5-trifluorophenylacetic acid, comprising an equipment frame, a heating reaction vessel, a cooling reaction vessel, a stirring device and a crystallization filter box, wherein the heating reaction vessel, the cooling reaction vessel and the crystallization filter box are arranged on the equipment frame, the heating reaction vessel and the cooling reaction vessel are detachably provided with end covers, the end covers are provided with liquid inlet end pipes, the stirring device comprises a driving stirring motor, a reduction box I, a shaft seat, a driving shaft, a screw belt and a connecting rod, the driving stirring motor is connected to the reduction box I for control transmission, the shaft seat is located at the lower part of the reduction box I, The output of the reduction box I is connected to the drive shaft, the connecting rod is arranged between the drive shaft and the screw belt, the equipment frame is provided with a lifting mechanism, and the lifting mechanism is provided with a movable frame for lifting, and the movable frame is fixedly installed on one side of the reduction box I, the heating reaction container is provided with a heating chamber, and the heating chamber is provided with an electromagnetic heating coil, the heating reaction container is provided with an output connector, and a boost output pipe is provided on the output end, and the boost output pipe is connected to the cooling reaction container, and a cooling coil is provided in the cooling reaction container, and the cooling reaction container is provided with a downward output pipe, and the downward output pipe is connected to the crystallization filter box.

[0006] As a preferred embodiment of the utility model, the equipment frame is provided with an upper horizontal plate and a lower horizontal plate, the heating reaction vessel and the cooling reaction vessel are provided with supporting feet, the supporting feet are located on the upper horizontal plate, and the crystallization filter box is located on the lower horizontal plate.

[0007] As a preferred embodiment of the present invention, temperature sensors are provided on the heating reaction container and the cooling reaction container.

[0008] As a preferred embodiment of the utility model, a limited step surface and a storage box are provided in the crystallization filter box, a crystal filter screen is installed on the limited step surface, the storage box is located below the crystal filter screen, an upper sealed door panel and a lower sealed door panel are hingedly provided on the crystallization filter box, and opening handles are provided on the upper sealed door panel and the lower sealed door panel.

[0009] As a preferred embodiment of the present invention, a catalyst input pipe joint is provided on the end cover.

[0010] As a preferred embodiment of the utility model, the inner top of the end cover is provided with a plug-in groove, a sealing ring is installed in the plug-in groove, the tops of the heating reaction container and the cooling reaction container are plugged into the plug-in groove and abut against the sealing ring for sealing, and the outside of the end cover is provided with bolts for locking the heating reaction container and the cooling reaction container respectively.

[0011] As a preferred embodiment of the present invention, a bottom stirring blade is provided at the bottom end of the driving shaft.

[0012] As a preferred embodiment of the utility model, the lifting mechanism includes an inner hollow fixed bracket, the bottom of the inner hollow fixed bracket is fixedly installed on the equipment frame, the side of the inner hollow fixed bracket is provided with a guide rod, the inner rotation of the movable frame is provided with a guide wheel, the guide wheel is directional and movable on the guide rod, the guide wheel is provided with a recess matching the guide rod, the top of the inner hollow fixed bracket is provided with a top fixing ear and a reduction box II, the top fixing ear is fixedly installed on the equipment frame, the reduction box II is transmission-connected with a lifting drive motor, the output of the reduction box II is provided with a screw, the screw is transmission-provided with a screw nut sleeve, a lifting block is provided outside the screw nut sleeve, a connecting rod is provided on the lifting block, and the connecting rod is fixedly installed on the movable frame.

[0013] As a preferred embodiment of the present invention, a guiding inclined surface is provided in the output connector.

[0014] As a preferred embodiment of the present invention, an opening and closing valve I is provided on the output joint, and an opening and closing valve II is provided on the downward output pipe.

[0015] By adopting the above technical solution, the utility model has the following advantages compared with the prior art:

[0016] The utility model has a simple and reasonable structure. In the process of preparing 2,4,5-trifluorophenylacetic acid, it is generally necessary to mix the catalyst and other solutions, and to perform heating, cooling and crystallization processes. The refining reaction equipment is provided with a heating reaction container and a cooling reaction container. First, the reaction materials enter the reaction material through the liquid inlet end tube, and the corresponding catalyst is added. By driving the transmission control connection of the stirring motor and the reduction box I, the driving shaft can be controlled to rotate, thereby driving the spiral ribbon to stir. The spiral ribbon structure is adopted, and the stirring can be performed up and down, which greatly improves the adequacy of the mixing reaction. Secondly, the electromagnetic heating coil can achieve the function of rapid heating, and the cooling coil can be connected to the cooling water circulation system to achieve the function of rapid cooling, thereby achieving the heating and mixing. and cooling crystallization effects are better. Through the setting of the crystallization filter box, the crystals can be filtered well to obtain the required crystals. In summary, the equipment integrates the functions of heating, cooling, crystallization and mixing, and is easier to use. When the end covers are respectively in a disassembled and relatively separated state from the heating reaction vessel and the cooling reaction vessel, the movable frame can be driven to move up and down through the setting of the lifting mechanism. Since the movable frame is fixedly installed with the reduction box I, the end covers and the stirring device can be driven to lift upward and escape from the heating reaction vessel and the cooling reaction vessel, thereby facilitating a thorough cleaning of the interior of the heating reaction vessel and the cooling reaction vessel, and at the same time, the screw belt and the drive shaft on the stirring device can also be thoroughly cleaned, and the separation and cleaning effect is better. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings:

[0018] Figure 1 It is a structural schematic diagram of the utility model;

[0019] Figure 2 This is a schematic diagram of the separate structure of the heating reaction container and the end cover of the utility model;

[0020] Figure 3 It is a schematic diagram of part A of the utility model;

[0021] Figure 4 This is a schematic diagram of the structure of the lifting mechanism and stirring device of the utility model;

[0022] Figure 5 This is a schematic diagram of the lifting mechanism of the utility model when the inner hollow fixed bracket is removed;

[0023] Figure 6 This is a structural schematic diagram of the crystallization filter box of the utility model;

[0024] Figure 7 It is a schematic diagram of the separation of the crystal filter screen, storage box and crystal filter box of the utility model;

[0025] In the figure: 1. Equipment frame; 2. Heating reaction vessel; 3. Cooling reaction vessel; 4. Crystallization filter box; 5. End cover; 6. Liquid inlet end pipe; 7. Driving stirring motor; 8. Speed ​​reducer I; 9. Shaft seat; 10. Driving shaft; 11. Screw belt; 12. Connecting rod; 13. Movable frame; 14. Heating chamber; 15. Electromagnetic heating coil; 16. Output connector; 17. Boost output pipe; 18. Cooling coil; 19. Downward output pipe; 20. Upper horizontal plate; 21. Lower horizontal plate; 22. Support foot; 23. Temperature sensor; 24. Limiting step surface; 25. Storage Box; 26, crystal filter; 27, upper sealing door plate; 28, lower sealing door plate; 29, opening handle; 30, catalyst input pipe joint; 31, plug-in slot; 32, sealing ring; 33, bolt; 34, bottom stirring blade; 35, inner hollow fixing bracket; 36, guide rod; 37, guide wheel; 38, recess; 39, top fixing ear; 40, reduction box II; 41, lifting drive motor; 42, screw rod; 43, screw rod nut sleeve; 44, lifting block; 45, connecting rod; 46, guide ramp; 47, opening and closing valve I; 48, opening and closing valve II. DETAILED DESCRIPTION

[0026] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model. Example

[0027] See also Figure 1-7 The utility model provides a technical solution: a refining reaction device for 2,4,5-trifluorophenylacetic acid, comprising an equipment frame 1, a heating reaction vessel 2, a cooling reaction vessel 3, a stirring device and a crystallization filter box 4, wherein the heating reaction vessel 2, the cooling reaction vessel 3 and the crystallization filter box 4 are arranged on the equipment frame 1, and the heating reaction vessel 2 and the cooling reaction vessel 3 are detachably provided with end covers 5, and the end covers 5 are provided with liquid inlet end pipes 6, and the stirring device comprises a driving stirring motor 7, a reduction box I8, a shaft seat 9, a driving shaft 10, a screw belt 11 and a connecting rod 12, and the driving stirring motor 7 is connected to the reduction box I8 for control transmission, and the shaft seat 9 is located at the lower part of the reduction box I8, and the reduction box I 8 output connection drive shaft 10, the connecting rod 12 is arranged between the drive shaft 10 and the screw belt 11, the equipment frame 1 is provided with a lifting mechanism, and the lifting mechanism is provided with a movable frame 13, the movable frame 13 is fixedly installed on one side of the reduction box I8, the heating reaction vessel 2 is provided with a heating chamber 14, the heating chamber 14 is provided with an electromagnetic heating coil 15, the heating reaction vessel 2 is provided with an output connector 16, the output end 16 is provided with a boost output pipe 17, the boost output pipe 17 is connected to the cooling reaction vessel 3, the cooling reaction vessel 3 is provided with a cooling coil 18, the cooling reaction vessel 3 is provided with a downward output pipe 19, and the downward output pipe 19 is connected to the crystallization filter box 4.

[0028] The utility model has a simple and reasonable structure. In the process of preparing 2,4,5-trifluorophenylacetic acid, it is generally necessary to mix the catalyst and other solutions, and to perform heating, cooling and crystallization processes. The refining reaction equipment is provided with a heating reaction vessel 2 and a cooling reaction vessel 3. First, the reaction materials enter the liquid inlet end pipe 6, and the corresponding catalyst is added. By driving the transmission control connection of the stirring motor 7 and the reduction box 18, the driving shaft 10 can be controlled to rotate, thereby driving the spiral ribbon 11 to stir. The spiral ribbon 11 structure can be used to stir up and down, greatly improving the adequacy of the mixing reaction. Secondly, the electromagnetic heating coil 15 can achieve the function of rapid heating, and the cooling coil 18 can be connected to the cooling water circulation system to achieve the function of rapid cooling, thereby achieving heating, mixing and The effect of cooling crystallization is better. Through the setting of the crystallization filter box 4, the crystals can be filtered well to obtain the required crystals. In summary, the equipment integrates the functions of heating, cooling, crystallization and mixing, and has better usability. When the end cover 5 is in a disassembled and relatively separated state from the heating reaction vessel 2 and the cooling reaction vessel 3, the movable frame 13 can be driven to move up and down through the setting of the lifting mechanism. Since the movable frame 13 is fixedly installed with the reduction box I8, the end cover 5 and the stirring device can be driven to lift upward and disengage from the heating reaction vessel 2 and the cooling reaction vessel 3, thereby facilitating the thorough cleaning of the interior of the heating reaction vessel 2 and the cooling reaction vessel 3, and at the same time, the screw belt 11 and the drive shaft 10 on the stirring device can also be thoroughly cleaned, and the separation and cleaning effect is better.

[0029] Specifically, the setting of the heating reaction vessel 2 and the cooling reaction vessel 3 achieves the separate use of heating and cooling. The connecting rod 12 is used for the installation connectivity of the screw belt 11 and the drive shaft 10. The shaft seat 9 is used for the rotational installation of the drive shaft 10. The heat generated by the electromagnetic heating coil 15 is transferred to the heating reaction vessel 2 through the heating chamber 14. The output connector 16 is used to output after the heating reaction is completed, and reaches the cooling reaction vessel 3 through the boost output pipe 17. Through the downward output pipe 19, it reaches the crystallization filter box 4 for filtration.

[0030] Furthermore, an upper horizontal plate 20 and a lower horizontal plate 21 are provided on the equipment frame 1 , the heating reaction vessel 2 and the cooling reaction vessel 3 are provided with support legs 22 , the support legs 22 are located on the upper horizontal plate 20 , and the crystallization filter box 4 is located on the lower horizontal plate 21 .

[0031] In this embodiment, through this structure, the heating reaction vessel 2, the cooling reaction vessel 3 and the crystallization filter box 4 can be stably placed.

[0032] Furthermore, temperature sensors 23 are provided on the heating reaction container 2 and the cooling reaction container 3 .

[0033] In this embodiment, the temperature in the heating reaction container 2 and the cooling reaction container 3 can be detected by the temperature sensor 23, so as to facilitate the subsequent temperature adjustment.

[0034] Furthermore, a limited step surface 24 and a storage box 25 are provided in the crystallization filter box 4, a crystal filter screen 26 is installed on the limited step surface 24, the storage box 25 is located below the crystal filter screen 26, and an upper sealing door panel 27 and a lower sealing door panel 28 are hingedly provided on the crystallization filter box 4, and opening handles 29 are provided on the upper sealing door panel 27 and the lower sealing door panel 28.

[0035] In this embodiment, the crystal filter 26 can be well limited and installed by the limiting step 24. Secondly, when the crystals filtered out by the crystal filter 26 meet the standards, they are stored in the storage box 25. The handle 29 can be opened or closed to open or close the upper sealing door panel 27 and the lower sealing door panel 28, so as to facilitate the operation of the crystal filter 26 and the storage box 25.

[0036] Furthermore, a catalyst input pipe joint 30 is provided on the end cover 5 .

[0037] In this embodiment, the catalyst is added separately through the catalyst input pipe joint 30 .

[0038] Furthermore, a plug-in groove 31 is provided at the inner top of the end cover 5, and a sealing ring 32 is installed in the plug-in groove 31. The tops of the heating reaction vessel 2 and the cooling reaction vessel 3 are plugged into the plug-in groove 31 and abut against the sealing ring 32 for sealing. The outside of the end cover 5 is provided with bolts 33 for locking the heating reaction vessel 2 and the cooling reaction vessel 3 respectively.

[0039] In this embodiment, the initial limited installation is achieved through plug-in cooperation, and then the sealing ring 32 abuts to achieve better sealing, and the bolts 33 are used to install the device securely and facilitate disassembly.

[0040] Further, a bottom stirring blade 34 is provided at the bottom end of the driving shaft 10 .

[0041] In this embodiment, the upper port of the output connector 16 can be stirred by the bottom stirring blade 34, and the spiral ribbon 11 is used for stirring, so as to achieve comprehensive stirring and mixing, and the mixing is relatively sufficient.

[0042] Furthermore, the lifting mechanism includes an inner hollow fixed bracket 35, the bottom of the inner hollow fixed bracket 35 is fixedly installed on the equipment frame 1, the side of the inner hollow fixed bracket 35 is provided with a guide rod 36, the internal rotation of the movable frame 13 is provided with a guide wheel 37, the guide wheel 37 is directional and movable on the guide rod 36, and the guide wheel 36 is provided with a recess 38 matching the guide rod 37, the top of the inner hollow fixed bracket 35 is provided with a top fixing ear 39 and a reduction box II40, the top fixing ear 39 is fixedly installed on the equipment frame 1, the reduction box II40 is transmission-connected with a lifting drive motor 41, the reduction box II40 is output-provided with a screw rod 42, the screw rod 42 is transmission-provided with a screw nut sleeve 43, a lifting block 44 is provided outside the screw nut sleeve 43, the lifting block 44 is provided with a connecting rod 45, and the connecting rod 45 is fixedly installed on the movable frame 13.

[0043] In this embodiment, the lifting drive motor 41 uses the reduction box II40 to drive the screw rod 42 to rotate, and the screw rod 42 drives the screw nut sleeve 43 to lift and lower, thereby driving the lifting block 44 and the movable frame 13 to lift and lower, wherein the guide wheel 36 is directional and movablely arranged on the guide rod 37, so as to achieve directional and stable lifting of the movable frame 13, thereby being able to drive the end cover 5 and the stirring device to be lifted upward stably.

[0044] Furthermore, a guiding inclined surface 46 is provided in the output connector 16 .

[0045] In the present embodiment, the output guiding can be achieved by means of the guide bevel 46 .

[0046] Furthermore, an opening and closing valve I47 is provided on the output joint 16 , and an opening and closing valve II48 is provided on the downward output pipe 19 .

[0047] In this embodiment, through the opening and closing valve I47, it is necessary to set the closed state when heating the mixing reaction, and open it when discharging the material. Through the opening and closing valve II48, it is necessary to set the closed state when cooling and crystallization are required, and open it when discharging the material.

[0048] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0049] Finally, it should be noted that the above description is only a preferred embodiment of the utility model and is not intended to limit the utility model. Although the utility model is described in detail with reference to the above embodiments, those skilled in the art can still modify the technical solutions recorded in the above embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. A refining reaction device for 2,4,5-trifluorophenylacetic acid, characterized in that: The invention comprises an equipment frame (1), a heating reaction container (2), a cooling reaction container (3), a stirring device and a crystallization filter box (4); the heating reaction container (2), the cooling reaction container (3) and the crystallization filter box (4) are arranged on the equipment frame (1); the heating reaction container (2) and the cooling reaction container (3) are detachably provided with end covers (5); the end covers (5) are provided with liquid inlet end pipes (6); the stirring device comprises a driving stirring motor (7), a reduction box I (8), a shaft seat (9), a driving shaft (10), a screw belt (11) and a connecting rod (12); the driving stirring motor (7) is connected to the reduction box I (8) in a control transmission manner; the shaft seat (9) is located at the lower part of the reduction box I (8); the output of the reduction box I (8) is connected to the driving shaft (10); the connecting rod (12) is provided A lifting mechanism is provided on the equipment frame (1) between the drive shaft (10) and the screw belt (11), and a movable frame (13) is provided on the lifting mechanism for lifting, and the movable frame (13) is fixedly installed on one side of the reduction box I (8). The heating reaction container (2) is provided with a heating chamber (14), and an electromagnetic heating coil (15) is provided in the heating chamber (14). The heating reaction container (2) is provided with an output connector (16), and a boost output pipe (17) is provided on the output connector (16). The boost output pipe (17) is connected to the cooling reaction container (3), and a cooling coil (18) is provided in the cooling reaction container (3). The cooling reaction container (3) is provided with a downward output pipe (19), and the downward output pipe (19) is connected to the crystallization filter box (4).

2. A refining reaction device for 2,4,5-trifluorophenylacetic acid according to claim 1, characterized in that: An upper transverse plate (20) and a lower transverse plate (21) are provided on the equipment frame (1); the heating reaction vessel (2) and the cooling reaction vessel (3) are provided with support legs (22); the support legs (22) are located on the upper transverse plate (20); and the crystallization filter box (4) is located on the lower transverse plate (21).

3. A refining reaction device for 2,4,5-trifluorophenylacetic acid according to claim 1, characterized in that: The heating reaction container (2) and the cooling reaction container (3) are provided with temperature sensors (23).

4. A refining reaction device for 2,4,5-trifluorophenylacetic acid according to claim 1, characterized in that: A limited step surface (24) and a storage box (25) are provided in the crystallization filter box (4); a crystal filter screen (26) is installed on the limited step surface (24); the storage box (25) is located below the crystal filter screen (26); an upper sealing door panel (27) and a lower sealing door panel (28) are hingedly provided on the crystallization filter box (4); and opening handles (29) are provided on the upper sealing door panel (27) and the lower sealing door panel (28).

5. A refining reaction device for 2,4,5-trifluorophenylacetic acid according to claim 1, characterized in that: The end cover (5) is provided with a catalyst input pipe joint (30).

6. A refining reaction device for 2,4,5-trifluorophenylacetic acid according to claim 1, characterized in that: The inner top of the end cover (5) is provided with a plug-in groove (31), a sealing ring (32) is installed in the plug-in groove (31), the tops of the heating reaction container (2) and the cooling reaction container (3) are plugged into the plug-in groove (31) and abut against the sealing ring (32) to seal, and the outside of the end cover (5) is provided with bolts (33) for locking the heating reaction container (2) and the cooling reaction container (3) respectively.

7. A purification reaction device for 2,4,5-trifluorophenylacetic acid according to claim 1, characterized in that: A bottom stirring blade (34) is provided at the bottom end of the driving shaft (10).

8. A purification reaction equipment for 2,4,5-trifluorophenylacetic acid according to claim 1, characterized in that: The lifting mechanism comprises an inner hollow fixed bracket (35), the bottom of the inner hollow fixed bracket (35) is fixedly mounted on the equipment frame (1), a guide rod (36) is provided on the side of the inner hollow fixed bracket (35), a guide wheel (37) is rotatably provided inside the movable frame (13), the guide wheel (37) is directional and movablely provided on the guide rod (36), the guide wheel (37) is provided with a recess (38) that matches the guide rod (36), and a top fixing ear (38) is provided on the top of the inner hollow fixed bracket (35). 9) and a reduction box II (40), the top fixing ear (39) is fixedly mounted on the equipment frame (1), the reduction box II (40) is transmission-connectedly provided with a lifting drive motor (41), the reduction box II (40) is output-arranged with a lead screw (42), the lead screw (42) is transmission-arranged with a lead screw nut sleeve (43), a lifting block (44) is arranged outside the lead screw nut sleeve (43), a connecting rod (45) is arranged on the lifting block (44), and the connecting rod (45) is fixedly mounted on the movable frame (13).

9. A purification reaction device for 2,4,5-trifluorophenylacetic acid according to claim 1, characterized in that: A guiding inclined surface (46) is provided inside the output connector (16).

10. A purification reaction device for 2,4,5-trifluorophenylacetic acid according to claim 1, characterized in that: The output connector (16) is provided with an on-off valve I (47), and the downward output pipe (19) is provided with an on-off valve II (48).

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