Constant temperature device of liquid chromatograph-mass spectrometer for pharmacokinetics experiment

Abstract

The utility model discloses a constant temperature device of a liquid chromatograph-mass spectrometer for pharmacokinetics experiments. The constant temperature device comprises an instrument shell and a cooling assembly I, a first baffle is hinged to the front side of the instrument shell, a second cooling assembly is installed on the left side of the instrument shell, a drying assembly and a fastening assembly are installed on the left side and the right side of the instrument shell and matched with each other, and a water absorption assembly is installed in the instrument shell. The first cooling assembly comprises a water pump, a connecting pipe, a flow guide pipe and a backflow pipe, the water pump is mounted on the left side of the instrument shell, the connecting pipe is fixed in a water outlet formed in the lower side of the water pump, a mounting groove is formed in the rear side in the instrument shell, and the flow guide pipe is fixed in the mounting groove; the lower end of the connecting pipe is connected with the lower end of the flow guide pipe. The cooling device can be used for cooling when the temperature of the liquid chromatograph-mass spectrometer is too high, so that the internal temperature of the liquid chromatograph-mass spectrometer is kept constant, and a medicine to be detected can be prevented from being blown away.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmacokinetic experiments, in particular to a constant temperature device for a pharmacokinetic experiment liquid-mass spectrometer. Background Art

[0002] Liquid spectrometry is mainly used in drug metabolism and pharmacokinetic research, clinical pharmacology research, natural medicine (Chinese herbal medicine, etc.) development research, neonatal screening, protein and peptide identification, residue analysis, toxicology analysis, environmental analysis - environmental protection, food, tap water, health and epidemic prevention and other industries.

[0003] During the use of liquid-mass spectrometer, the electronic equipment inside it will generate a lot of heat. If this heat cannot be discharged in time, it will not only affect the service life of the liquid-mass spectrometer, but also may cause a fire, thus causing certain safety hazards and affecting the service life and safety of the liquid-mass spectrometer. The cooling device of the existing liquid-mass spectrometer blows cold air into the inside of the instrument for cooling. When the cold air is blown into the inside of the instrument, it may blow away the objects to be detected inside the instrument, affecting the judgment of the test results. Utility Model Content

[0004] The technical problem to be solved by the utility model is to overcome the existing defects and provide a constant temperature device for a pharmacokinetic experiment liquid-mass spectrometer, which can cool down the liquid-mass spectrometer when the temperature is too high, maintain the internal temperature of the liquid-mass spectrometer constant, and avoid blowing away the drugs to be tested, thereby effectively solving the problems in the background technology.

[0005] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a constant temperature device for a pharmacokinetic experiment liquid-mass spectrometer, comprising an instrument housing and a cooling component;

[0006] A baffle plate 1 is hingedly connected to the front side of the instrument housing, a cooling assembly 2 is installed on the left side of the instrument housing, a matching drying assembly and a fastening assembly are installed on the left and right sides of the instrument housing, and a water absorption assembly is installed inside the instrument housing;

[0007] The cooling component 1 includes a water pump, a connecting pipe, a guide pipe and a return pipe. The water pump is installed on the left side of the instrument shell, and a connecting pipe is fixed inside the water outlet arranged on the lower side of the water pump. An installation groove is opened on the rear side of the inside of the instrument shell, and a guide pipe is fixed inside the installation groove. The lower end of the connecting pipe is connected to the lower end of the guide pipe, and a return pipe is fixed to the upper end of the guide pipe. The input end of the water pump is electrically connected to the output end of an external PLC controller.

[0008] Furthermore, the second cooling component includes a water outlet pipe, a water storage tank, a semiconductor refrigeration sheet, a first temperature sensor and a sealing plug. The water outlet pipe is fixed inside the water inlet arranged on the water pump toilet, and the upper end of the water outlet pipe is fixed inside the water outlet arranged on the lower side of the water storage tank. The water storage tank is fixed on the left side of the instrument shell. An installation groove is opened on the left side of the water storage tank, and a semiconductor refrigeration sheet is installed inside the installation groove. The heat dissipation end of the semiconductor refrigeration sheet is located outside the installation groove, and the cooling end of the semiconductor refrigeration sheet is located inside the installation groove. A connecting groove is opened on the rear side of the water storage tank, and a first temperature sensor is installed inside the connecting groove. A sealing plug is fixed inside the water injection hole arranged on the left side of the water storage tank. The first temperature sensor is bidirectionally electrically connected to an external PLC controller. The input end of the semiconductor refrigeration sheet is electrically connected to the output end of the external PLC controller. The water inside the water storage tank is cooled by arranging the semiconductor refrigeration sheet.

[0009] Furthermore, the drying component includes a screen frame, baffle plate 2 and a desiccant. Two corresponding openings are provided on the left and right sides of the instrument shell. The screen frame is clamped inside the opening. Baffle plate 2 is fixed on the side of the screen frame located outside the instrument shell. Desiccant is placed inside the screen frame. By setting up the drying component, the inside of the instrument shell can be effectively kept dry.

[0010] Furthermore, the fastening assembly includes a rotating shaft, a fastening plate and a torsion spring. Two corresponding rotating shafts are rotatably connected to the left and right sides of the instrument case. A fastening plate is fixed to the end face of the rotating shaft. The fastening plate is fitted with the side face of the second baffle. A torsion spring is sleeved on the circumferential surface of the rotating shaft. One end of the torsion spring is fixed to the side face of the instrument case, and the other end of the torsion spring is fixed to the side face of the fastening plate. The baffle is fixed by setting the fastening assembly.

[0011] Furthermore, the water absorption component includes a fixing frame, a water-absorbent cotton frame, a cotton board and a second temperature sensor. The fixing frame is fixed on the lower side of the inside of the instrument shell, the water-absorbent cotton frames are fixed on both the inner and outer sides of the fixing frame, the cotton board is fixed on the upper side of the fixing frame, and the second temperature sensor is fixed inside the internal water-absorbent cotton frame. The second temperature sensor is bidirectionally electrically connected to the external PLC controller, and the water inside the instrument shell is absorbed by setting the water absorption component.

[0012] Furthermore, two corresponding guide grooves are provided at the left and right ends of the lower inner side of the instrument housing, and an oblique guide block is fixed inside the guide groove, and water is guided by arranging the guide groove and the oblique guide block.

[0013] Compared with the prior art, the beneficial effects of the utility model are:

[0014] 1. The temperature inside the instrument case is detected by setting a second temperature sensor. When the temperature is too high, the water pump is started to pump the water inside the water storage tank into the inside of the guide pipe. The water entering the guide pipe can lower the temperature inside the instrument case as it moves along the guide pipe. In this case, the temperature inside the instrument case can be effectively kept constant.

[0015] 2. By setting up a drying component, the moisture inside the instrument shell can be absorbed during use, and after absorption, the moisture can be prevented from affecting the normal operation of the electrical components inside the instrument shell. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a schematic diagram of the front structure of the utility model;

[0017] Figure 2 This is a schematic diagram of the cooling component structure of the utility model;

[0018] Figure 3 This is a schematic diagram of the structure of the fastening assembly of the utility model;

[0019] Figure 4 This is a schematic diagram of the structure of the water absorbing component of the utility model.

[0020] In the figure: 1 instrument housing, 2 baffle 1, 3 cooling component 1, 31 water pump, 32 connecting pipe, 33 guide pipe, 34 return pipe, 4 cooling component 2, 41 outlet pipe, 42 water storage tank, 43 semiconductor refrigeration plate, 44 first temperature sensor, 45 sealing plug, 5 drying component, 51 mesh frame, 52 baffle 2, 53 desiccant, 6 fastening component, 61 rotating shaft, 62 fastening plate, 63 torsion spring, 7 water absorption component, 71 fixing frame, 72 water absorption cotton frame, 73 cotton plate, 74 second temperature sensor, 8 guide groove, 9 oblique guide block. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0022] See also Figure 1-4The present embodiment provides a technical solution: a constant temperature device for a pharmacokinetic experiment liquid-mass spectrometer, comprising an instrument shell 1 and a cooling component 3; a baffle 2 is hingedly connected to the front side of the instrument shell 1, a cooling component 4 is installed on the left side of the instrument shell 1, a matching drying component 5 and a fastening component 6 are installed on the left and right sides of the instrument shell 1, and a water absorption component 7 is installed inside the instrument shell 1; two corresponding guide grooves 8 are provided at the left and right ends of the lower side of the inside of the instrument shell 1, and an oblique guide block 9 is fixed inside the guide groove 8, and water is guided by setting the guide groove 8 and the oblique guide block 9.

[0023] Among them, the cooling component 3 includes a water pump 31, a connecting pipe 32, a guide pipe 33 and a return pipe 34. The water pump 31 is installed on the left side of the instrument shell 1, and the connecting pipe 32 is fixed inside the water outlet arranged on the lower side of the water pump 31. An installation groove is opened on the rear side of the inside of the instrument shell 1, and the guide pipe 33 is fixed inside the installation groove. The lower end of the connecting pipe 32 is connected to the lower end of the guide pipe 33, and the upper end of the guide pipe 33 is fixed with a return pipe 34. The input end of the water pump 31 is electrically connected to the output end of the external PLC controller. The interior of the instrument shell 1 is cooled by setting the cooling component 3.

[0024] Among them, cooling component 2 4 includes a water outlet pipe 41, a water tank 42, a semiconductor refrigeration sheet 43, a first temperature sensor 44 and a sealing plug 45. The water outlet pipe 41 is fixed inside the water inlet set on the water pump 31. The upper end of the water outlet pipe 41 is fixed inside the water outlet set on the lower side of the water tank 42. The water tank 42 is fixed on the left side of the instrument shell 1. An installation groove is opened on the left side of the water tank 42. A semiconductor refrigeration sheet 43 is installed inside the installation groove. The heat dissipation end of the semiconductor refrigeration sheet 43 is located outside the installation groove, and the cooling end of the semiconductor refrigeration sheet 43 is located inside the installation groove. A connecting groove is opened on the rear side of the water tank 42. The first temperature sensor 44 is installed inside the connecting groove. The sealing plug 45 is fixedly connected to the inside of the water injection hole set on the left side of the water tank 42. The first temperature sensor 44 is bidirectionally electrically connected to the external PLC controller, and the input end of the semiconductor refrigeration sheet 43 is electrically connected to the output end of the external PLC controller.

[0025] Among them, the drying component 5 includes a screen frame 51, a baffle 52 and a desiccant 53. Two corresponding openings are provided on the left and right sides of the instrument housing 1. The screen frame 51 is clamped inside the opening. The baffle 52 is fixed on the side of the screen frame 51 located outside the instrument housing 1, and a desiccant 53 is placed inside the screen frame 51.

[0026] Among them, the fastening assembly 6 includes a rotating shaft 61, a fastening plate 62 and a torsion spring 63. Two corresponding rotating shafts 61 are rotatably connected to the left and right sides of the instrument housing 1. A fastening plate 62 is fixed on the end surface of the rotating shaft 61. The fastening plate 62 is in contact with the side surface of the baffle 2 52. A torsion spring 63 is sleeved on the circumferential surface of the rotating shaft 61. One end of the torsion spring 63 is fixed to the side surface of the instrument housing 1, and the other end of the torsion spring 63 is fixed to the side surface of the fastening plate 62.

[0027] Among them, the water absorption component 7 includes a fixing frame 71, a water absorption cotton frame 72, a cotton board 73 and a second temperature sensor 74. The fixing frame 71 is fixed to the lower side of the inside of the instrument shell 1, and the water absorption cotton frame 72 is fixed to the inner and outer sides of the fixing frame 71. The cotton board 73 is fixed to the upper side of the fixing frame 71. The inside of the internal water absorption cotton frame 72 is fixed with a second temperature sensor 74. The second temperature sensor 74 is bidirectionally electrically connected to the external PLC controller. The water inside the instrument shell 1 is absorbed by setting the water absorption component 7, the baffle plate 2 52 is fixed by setting the fastening component 6, and the drying component 5 can effectively ensure that the inside of the instrument shell 1 is dry. The water inside the water storage tank 42 is cooled by setting the semiconductor refrigeration sheet 43.

[0028] The working principle of the utility model is as follows:

[0029] During normal use, the second temperature sensor 74 detects the temperature inside the instrument housing 1. When the temperature is too high, the external PLC controller automatically controls the semiconductor refrigeration sheet 43 to cool the water inside the water storage tank 42. After cooling, the external PLC controller automatically starts the water pump 31 to pump the water inside the water storage tank 42 into the guide pipe 33. The water entering the guide pipe 33 can reduce the temperature inside the instrument housing 1 while moving along the guide pipe 33.

[0030] When the temperature inside the instrument shell 1 reaches a suitable value, the external PLC controller will automatically control the water pump 31 to turn off. In this case, the temperature inside the instrument shell 1 can be effectively kept constant. During the cooling process, the moisture on the inner wall of the instrument shell 1 will be absorbed by the absorbent cotton frame 72 and the cotton board. At the same time, the desiccant 53 will also absorb the moisture inside the instrument shell 1. After absorption, the moisture can be prevented from affecting the normal operation of the electrical components inside the instrument shell 1.

[0031] It is worth noting that the external PLC controller disclosed in the above embodiments is specifically a Siemens S7-200, the water pump 31 can use a WQD6-12-0.55L1 water pump, the semiconductor refrigeration plate 43 can use a C1204 multi-stage semiconductor refrigeration plate, the first temperature sensor 44 and the second temperature sensor 74 can use LSCI-TZ03 laser focusing infrared temperature sensors, and the external PLC controller controls the operation of the water pump 31 and the semiconductor refrigeration plate 43 using methods commonly used in the prior art.

[0032] The above description is only an embodiment of the present invention, and does not limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made by using the contents of the specification and drawings of the present invention, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A constant temperature device for a pharmacokinetic experiment liquid chromatography-mass spectrometry instrument, characterized in that: It comprises an instrument housing (1) and a cooling assembly (3); The front side of the instrument housing (1) is hingedly connected with a baffle plate 1 (2); the left side of the instrument housing (1) is provided with a cooling assembly 2 (4); the left and right sides of the instrument housing (1) are provided with matching drying assemblies (5) and fastening assemblies (6); and the interior of the instrument housing (1) is provided with a water absorption assembly (7); The cooling component (3) comprises a water pump (31), a connecting pipe (32), a guide pipe (33) and a return pipe (34); the water pump (31) is installed on the left side of the instrument housing (1); a connecting pipe (32) is fixed inside a water outlet arranged on the lower side of the water pump (31); a mounting groove is provided on the rear side inside the instrument housing (1); a guide pipe (33) is fixed inside the mounting groove; the lower end of the connecting pipe (32) is connected to the lower end of the guide pipe (33); a return pipe (34) is fixed at the upper end of the guide pipe (33); and the input end of the water pump (31) is electrically connected to the output end of an external PLC controller.

2. The constant temperature device for a pharmacokinetic experiment liquid spectrometer according to claim 1, characterized in that: The cooling component 2 (4) comprises a water outlet pipe (41), a water storage tank (42), a semiconductor cooling sheet (43), a first temperature sensor (44) and a sealing plug (45); the water outlet pipe (41) is fixed inside the water inlet provided on the upper toilet of the water pump (31); the upper end of the water outlet pipe (41) is fixed inside the water outlet provided on the lower side of the water storage tank (42); the water storage tank (42) is fixed on the left side of the instrument housing (1); a mounting groove is provided on the left side of the water storage tank (42); a semiconductor cooling sheet (43) is installed inside the mounting groove; The heat dissipation end of the semiconductor refrigeration plate (43) is located outside the installation groove, and the cooling end of the semiconductor refrigeration plate (43) is located inside the installation groove. A connecting groove is provided on the rear side of the water storage tank (42), and a first temperature sensor (44) is installed inside the connecting groove. A sealing plug (45) is fixedly connected to the inside of the water injection hole arranged on the left side of the water storage tank (42). The first temperature sensor (44) is bidirectionally electrically connected to an external PLC controller, and the input end of the semiconductor refrigeration plate (43) is electrically connected to the output end of the external PLC controller.

3. The constant temperature device for a pharmacokinetic experiment liquid spectrometer according to claim 1, characterized in that: The drying component (5) comprises a screen frame (51), a second baffle plate (52) and a desiccant (53); two corresponding openings are provided on the left and right sides of the instrument housing (1); the screen frame (51) is clamped inside the opening; the second baffle plate (52) is fixed on the side surface of the screen frame (51) located outside the instrument housing (1); and the desiccant (53) is placed inside the screen frame (51).

4. The constant temperature device for a pharmacokinetic experiment liquid spectrometer according to claim 3, characterized in that: The fastening assembly (6) comprises a rotating shaft (61), a fastening plate (62) and a torsion spring (63). The left and right sides of the instrument housing (1) are rotatably connected to two corresponding rotating shafts (61). The end surface of the rotating shaft (61) is fixed with a fastening plate (62). The fastening plate (62) is in contact with the side surface of the second baffle plate (52). The circumferential surface of the rotating shaft (61) is sleeved with a torsion spring (63). One end of the torsion spring (63) is fixed to the side surface of the instrument housing (1), and the other end of the torsion spring (63) is fixed to the side surface of the fastening plate (62).

5. The constant temperature device for a pharmacokinetic experiment liquid spectrometer according to claim 1, characterized in that: The water absorption component (7) comprises a fixing frame (71), a water absorption cotton frame (72), a cotton board (73) and a second temperature sensor (74); the fixing frame (71) is fixed to the lower side of the interior of the instrument housing (1); the water absorption cotton frame (72) is fixed to both the inner and outer sides of the fixing frame (71); the cotton board (73) is fixed to the upper side of the fixing frame (71); the second temperature sensor (74) is fixed to the interior of the internal water absorption cotton frame (72); and the second temperature sensor (74) is bidirectionally electrically connected to an external PLC controller.

6. The constant temperature device for a pharmacokinetic experiment liquid spectrometer according to claim 1, characterized in that: Two corresponding guide grooves (8) are provided at the left and right ends of the lower inner side of the instrument housing (1), and an oblique guide block (9) is fixed inside the guide groove (8).

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