42 results about "Isoamoenylin" patented technology

The invention belongs to the technical field of medicaments, and in particular relates to application of isopentene group flavonoid compound used as a pancreatic lipase inhibitor. The flavonoid compound has the following structural formula and has a chemical name of: (E)-2-(2,4-dihydroxy phenyl)-5,7-dihydroxy-3-(3-methyl-2-butenyl)-6-(3-methy-l-butenyl)-4H-chromene-4-ketone, and can be extracted from artocarpus nitidus. Pancreatic lipase activity tests and experiments of weight loss action in animals prove that the compound has obvious pancreatic lipase inhibitory activity and weight loss action, can be taken as the lead compound for developing novel medicaments for preventing or curing obesity and related metabolic diseases, and also can be used for preparing the medicaments for preventing and curing clinically common multiple obesity and the related metabolic disease.

The invention relates to an isopentene flavonol glycoside derivative with a structure shown as a general formula (I) and a preparation method and application thereof. In the isopentene flavonol glycoside derivative, R1 refers to rhamnosyl, R2, R3, R4 and R7 refer to H, R5 refers to methoxyl, and R6 refers to hydroxyl; or R1, R4, R6 and R7 refer to H, R2 refers to xylosyl, R3 refers to acetyl, and R5 refers to hydroxyl; or R1, R3, R6 and R7 refer to H, R2 refers to xylosyl, R4 refers to glucosyl, and R5 refers to hydroxyl; or R1 refers to rhamnosyl, R2, R3 and R6 refer to H, R4 refers to glucosyl, R5 refers to methoxyl, and R7 refers to hydroxyl. The invention further relates to application of the isopentene flavonol glycoside derivative to the prevention and treatment of osteoporosis.

The invention provides a method for fully synthesizing and preparing dehydrated icariin. In the present invention, by using trihydroxyacetophenone, p-methoxybenzoyl chloride, prenyl bromide, etc. as raw materials, the prenyl group is first connected to the 8-position carbon through the rearrangement of the ortho position, and then the flavone skeleton is formed. A series of reactions are formed to obtain dehydrated icariin. The invention improves the disadvantages of low yield, expensive catalyst and many by-products of introducing isopentenyl groups in the traditional method, and has low cost, simple operation and good yield, and is suitable for industrialized production.

The present invention provides an optically active compound of general formula (I) and salts thereof: wherein R′ is selected from a group consisting of t-butyl amine, n-butylamine, iso-butylamine, iso-propyl amine, 4-phenyl-piperazine-1-ylamine, 4-(2-methoxyphenyl)-piperazin-1-ylamine, and 3,4-dimethoxy phenethyl amine; wherein R1, R2 and R3 are selected from the group consisting of hydrogen, methyl or iso pentenyl; R4, R5 and R6 are selected from the group consisting of Oil, O-alkyl, O-benzyl, O-substituted phenyl or combination thereof.

The invention relates to a method for introducing isopentenyl at the C3 position of indole. Specifically, using indole and isoprene as raw materials, under the promotion of a palladium catalyst / phosphine ligand, an isopentenyl group can be introduced at the C3 position of indole with high selectivity. The present invention has the following advantages: isoprene is a green bulk chemical, simple and easy to obtain, and cheap; simple indole can participate in the reaction without the need to protect NH; no leaving group, atom High economy.

The invention discloses a novel isopentenyl flavonoid compound, which is prepared by adopting the following steps: (1) taking Epimedium medicinal materials, pulverizing or not pulverizing, and extracting 1-3 times with a solvent, extracting 0.2-3 times each time After 3 hours, the two extracts were combined and concentrated under reduced pressure to obtain an extract; (2) water was added to the extract to obtain a suspension, the suspension was separated by gradient elution of macroporous resin, and then passed through an ODS column Gradient elution separation was performed, and finally the prenyl flavonoids were purified by high performance preparative liquid phase. The isopentenyl flavonoids can be converted into icariin under the conditions of heating, acid treatment, enzyme treatment, alkali treatment and the like. The invention is easy to operate, and the prepared compound has high purity.

The invention provides an application of a quinone chalcone compound in the preparation of antitumor drugs, the quinone chalcone compound is a quinone chalcone compound with a prenyl group in the A ring, and also provides such compounds in In the treatment of tumor diseases as a single drug or combined drug application, the quinoidal chalcone itself has a strong anti-tumor ability. When used in combination with anti-tumor drugs such as interferon, it can not only kill differentiated tumor cells, but also Killing the dormant tumor stem cells has the effect of completely eliminating tumor cells.

The invention discloses a quinoid chalcone compound with an isopentenyl group at an A ring, and a preparation method and anti-inflammatory activity thereof. The compound has a structure as shown in a general formula (I) which is described in the specification. The preparation method comprises the following steps: (1) synthesizing 3,5-dihydroxy-2-acetyl-6,6-diisopentenylcyclohexyl-2,4-dienone; (2) synthesizing 3-hydroxy-5-methoxy-2-acetyl-6,6-diisopentenylcyclohexyl-2,4-dienone; (3) synthesizing a methoxy group protected quinoid chalcone compound with the isopentenyl group at the A ring; and (4) synthesizing the quinoid chalcone compound with the isopentenyl group at the A ring. The compound is simple to prepare and has obvious anti-inflammatory action.

The invention relates to a method for extracting 5-isopentenyl aureusidin from eleocharis tuberose peels and belongs to the field of natural organic chemistry. The method is characterized by comprising the following steps of as an aqueous solution of acetone is used as a solvent, extracting the 5-isopentenyl aureusidin from the eleocharis tuberose peels to obtain an extract, extracting the extract with ethyl acetate to obtain an extractant, separating the extractant with a medium-pressure MCI column chromatography and a polyamide column chromatography to obtain a matter and repeatedly purifying the matter with a Sephadex LH-20 gel chromatography to obtain a 5-isopentenyl aureusidin product of which the content of the 5-isopentenyl aureusidin is above 95%. According to the method, a novel way for extracting and separating the 5-isopentenyl aureusidin from natural plants is created, the good separation effect is achieved, the product is high in purity, the eleocharis tuberose peels always regarded as wastes are changed into treasure, chromatographic materials, namely, MCI, polyamide and sol, can be repeatedly used, and the method has the advantages that raw materials are easily available, resources are abundant and the production cost is low; the product can be subjected to large-scale production and meets the needs of pharmaceutical industry.

The invention relates to isopentenyl stilbene and application thereof to preparation of drugs for treating inflammatory diseases. The isopentenyl stilbene is a new compound separated from artocarpus styracifolius Pierre which is a moraceae artocarpus plant, is named (+ / -)-artocarpus styracifolius phenol D, and has a structure as shown in the following description. The compound has strong inhibitory activity on rat polymorphonuclear neutrophils (PMNs) respiratory burst, the IC50 is 1.5+ / -0.22 muM, and the compound can be further used for preparing the drugs for treating the inflammatory diseases, and is used in clinical treatment of various oxidative damage, such as rheumatoid arthritis, compensatory anti-inflammatory response syndrome (CARS), and systemic inflammatory response syndrome (SIRS), caused by the excessive activation of PMNs.

Being applicable to the field of natural drugs, the invention provides application of a prenylflavanone compound with a structure shown as formula I in the specification in preparation of drugs and health care products for control of bone diseases. Specifically, the prenylflavanone compound comprises a compound 1 with R1 shown as the specification and R2 as H, and a compound 2 with R1 as H and R2 shown as the specification.

The invention belongs to the technical field of chemical industry, and specifically relates to the preparation method and application of five prenyl-containing flavonoid compounds; the compound of the present invention is isolated from the dried roots and rhizomes of Glycyrrhiza uralensis Fisch. in Yongxin Township, Jingyuan County, Gansu Province. It can be isolated by leaching, extraction and column chromatography. The five compounds have significant inhibitory effects on the combination of LAG3 / MHCⅡ or LAG3 / FGL1, which can provide candidate molecules for the development of new anti-tumor drugs, and provide a scientific basis for the development and utilization of Ural licorice (Glycyrrhiza uralensis Fisch.).

The present disclosure relates to a new class of cytokinin biosynthetic enzymes, cytokinin synthases, which have two domains: an isopentenyl transfer (IPT)-like domain and a cytokinin nucleotide phosphoribohydrolase (PRH)-like domain. The invention provides compositions and methods for the recombinant production of cytokinin synthase, host cells and transformants that include the cytokinin synthases, as well as compositions and formulations that include the disclosed cytokinin synthase.

The invention relates to a method for introducing a tertiary isopentenyl group at the C3 position of indole. Specifically, using indole and isoprene as raw materials, under the promotion of rhodium catalyst / phosphine ligand, a tertiary isopentenyl group can be introduced at the C3 position of indole with high selectivity. The present invention has the following advantages: isoprene is a green bulk chemical, simple and easy to obtain, and cheap; simple indole can participate in the reaction without the need to protect NH; no leaving group, atom High economy.

The invention relates to the technical field of medicinal microbial chemistry, and specifically discloses a strain of Bacillus chamois ( Stereum hirsutum ) isolated from the fermentation product of four isopentenyl substituted phenolic compounds for the preparation of antimicrobial drugs, specifically in the preparation of anti-Staphylococcus aureus and methicillin-resistant grape aureus Drug application for cocci growth. The antibacterial activity test of the present invention confirms that isopentenyl substituted phenolic compounds and derivatives thereof of the present invention can significantly inhibit Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (methicillin-resistant Staphylococcus aureus , MRSA), and has the application of preparing new agricultural or medical antibacterial and drug-resistant bacterial drugs.

The invention belongs to the technical field of medicine, and relates to a prenylflavonoid compound with a structure of formula (I) and its application. Specifically related to said compound 8-(3,4-dihydroxybenzene)-5-hydroxy-7-methoxy-2-hydroxymethyl-2-methyl-10-(3-methyl-2-butene Base)-2H, 6H-benzo[1,2-b:5,4-b']dipyran-6-one and its use in the preparation of protein tyrosine phosphatase 1B inhibitors. The compound is extracted from rattan. Experiments have confirmed that the compound has a strong inhibitory activity on protein tyrosine phosphatase 1B, and can be used as a protein tyrosine phosphatase 1B inhibitor and to develop new drugs for preventing or treating type 2 diabetes The lead compound of the invention can also be used for the preparation of drugs for preventing or treating type 2 diabetes which is commonly seen in clinical practice.

The invention discloses a field sampling treatment agent for date palm, comprising reagent A and reagent B, wherein the reagent A includes 1000-1500 times dilution of azoxystrobin, 1000-1500 times dilution of difenoconazole and carbendazim 800-1000-fold dilution, reagent B includes 6-benzylaminoadenine solution with mass concentration of 5-15mg / L and isopentenyl adenine solution with mass concentration of 1-5mg / L; preparation method: (1) Weigh azoxystrobin, difenoconazole and carbendazim, then dilute with water respectively, and mix to obtain reagent A; (2) weigh 6-benzylaminoadenine and isopentenyladenine, then use respectively Dissolve the sodium hydroxide solution, dilute to volume with sterile water, and mix to obtain reagent B. The field sampling treatment agent for the date palm of the invention can significantly reduce the fungal contamination rate and the endophyte contamination rate, so that the explants can maintain high differentiation ability, and it is easier to carry out detoxification treatment in the process of tissue culture, improve cell differentiation ability, and promote explants. Implants induce callus and shorten the induction period.