A method for performing guided self-examination of a subject's tissues is described. The method includes: positioning a handheld device comprising multiple electrodes and a certain amount of flexible material in general contact with a region of the subject's body; measuring the
capacitance between two of the electrodes; calculating tissue parameters based on the
capacitance; determining instructions for the subject in a controller based on the tissue parameters; and issuing instructions to the subject to guide the subject in manipulating the handheld device.