The invention discloses a hydrophilic-hydrophobic heterogeneous folded
polymer microsphere as well as a preparation method and application thereof. The
polymer microspheres are prepared from an oil-phase solution and a water-phase solution based on a suspension-
interfacial polymerization method, the oil-phase solution is prepared from a
hydrophobic monomer, a swelling
solvent and an initiator, and the
mass-volume ratio of the
hydrophobic monomer to the swelling
solvent to the initiator is (3-5) mL: (1-4) mL: (0.05-0.2) g; the water-phase solution is prepared from the following raw materials: a water-soluble
monomer, a stabilizer and a
solvent in a
mass-volume ratio of (0.5-2) mL: (1-2) g: (75-100) mL. The
polymer microspheres prepared by the method have good particle size uniformity, the surfaces of the microspheres are in a
wrinkle shape, and the polymer microspheres have large specific surface area and can be applied to the fields of
drug carriers, catalytic carriers or biosensors and the like.