Instant taurine eyes gel

A taurine eye, taurine technology, applied in the field of medicine, can solve the problems of restricting the curative effect of taurine eye drops, large loss of eye drops, expensive pharmaceutical excipients, etc., to achieve rich drug dosage forms and prolong retention Time, the effect of improving curative effect

Inactive Publication Date: 2007-11-21
肖正连
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology helps improve how drugs are taken up into our eyes without causing discomfort or other side-effects that may be caused during their use for treatment purposes. By doing this we aim to make it easier than ever before they can become less effective due to poor absorption from certain parts of the body's surface layer called ocular lens fluid (OCL).

Problems solved by technology

This patented technical problem addressed by this patents relates to finding ways to make stable and effective drug delivery systems that could last longer without losing their effects over time while maintaining good stability during storage under normal conditions such as temperatures.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Prescription: 5 grams of taurine, 400 milliliters of hydrochloric acid (0.15mol / L)

[0023] Sodium Citrate 17.6g Methylcellulose 5.0g Phenylethyl Alcohol 0.5g

[0024] Ethanol 5ml Sodium Chloride 5.0g PEG-1000 20g

[0025] PEG-400 5g water for injection appropriate amount

[0026] Preparation method: Heat water for injection to boil, cool to 80°C, add taurine, dissolve phenylethyl alcohol in ethanol, add dropwise to the above solution while stirring, add sodium citrate, stir for more than 30 minutes, then add hydrochloric acid Stir, filter through a microporous membrane (0.22μm), heat the filtrate to 40°C, add sodium chloride, methylcellulose, PEG-1000 and PEG-400 while hot, stir to room temperature (18-25°C) , and add water for injection to make up the weight to 1000 ml, stir to form a uniform gel, and aseptically pack it.

Embodiment 2

[0028] Prescription: 8 grams of taurine, 200 milliliters of sulfuric acid (0.15mol / L)

[0029] Sodium Citrate 17.6g Methylcellulose 5.0g Benzyl Alcohol 0.5g

[0030] Ethanol 5ml Sodium Chloride 5.5g PEG-1000 70g

[0031] Appropriate amount of water for injection

[0032] Preparation method: heat water for injection to boil, cool to 80°C, add taurine, dissolve benzyl alcohol in ethanol, add dropwise to the above solution while stirring, add sodium citrate, stir for more than 30 minutes, then add sulfuric acid Stir, filter through a microporous membrane (0.22μm), heat the filtrate to 40°C, add sodium chloride, methylcellulose and PEG-1000 while hot, stir to room temperature (18-25°C), and then inject Make up the weight with water to 1000 ml, stir to make it form a uniform gel, and aseptically dispense it.

Embodiment 3

[0034] Prescription: 5 grams of taurine, 200 milliliters of sodium hydroxide (0.1mol / L)

[0035] Boric acid 5.6g Methylcellulose 5.0g Sodium benzoate 0.5g

[0036] Ethanol 5ml Sodium Chloride 7.5g PEG-4000 100g

[0037] Appropriate amount of water for injection

[0038] Preparation method: heat and boil water for injection, cool to 80°C, add taurine, sodium citrate, sodium hydroxide and sodium benzoate, stir for more than 30 minutes, then add boric acid and stir, pass through a microporous membrane (0.22 μm), the filtrate was heated to 40°C, PEG-4000 and methylcellulose were added while it was hot, stirred to room temperature (18-25°C), and water for injection was added to make up the weight to 1000 ml, and stirred to form a uniform Gel, aseptically dispensed.

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Abstract

The invention is concerned with the method of preparation for the 1000ml. instant taurine ophthalmic gelatin. It contents: taurine 5-50g, antiseptic 0.05-1g, osmoregulation 1.0-7.5g, gel substrate 30-150g, and the certain amount of acid-base buffer and injection usage water to fulfill the requested weight of the medicine. The invention enriches the pharmaceutical dosage form of the taurine that prolongs the residence time of the medicine at the eye areas, and improves the curative effect with no negative stimulation.

Description

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Claims

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Application Information

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Owner 肖正连
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